Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

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weight		 Rot
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 DOI
16133225 419 None 52 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
172198 419 None 52 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
2504 419 None 52 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
45266664 419 None 52 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5272 419 None 52 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL408403 419 None 52 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
DB11842 419 None 52 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
16133225 419 None 52 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
172198 419 None 52 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
2504 419 None 52 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
45266664 419 None 52 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5272 419 None 52 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL408403 419 None 52 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
DB11842 419 None 52 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
127030943 139193 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787243 139193 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787375 139193 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787700 139193 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
127030943 139193 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787243 139193 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787375 139193 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787700 139193 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
16133225 419 None 52 Rat Functional pEC50 = 8.9 8.9 -6 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
172198 419 None 52 Rat Functional pEC50 = 8.9 8.9 -6 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
2504 419 None 52 Rat Functional pEC50 = 8.9 8.9 -6 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
45266664 419 None 52 Rat Functional pEC50 = 8.9 8.9 -6 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
5272 419 None 52 Rat Functional pEC50 = 8.9 8.9 -6 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL408403 419 None 52 Rat Functional pEC50 = 8.9 8.9 -6 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
DB11842 419 None 52 Rat Functional pEC50 = 8.9 8.9 -6 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
127029976 139215 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786145 139215 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787767 139215 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
127029976 139215 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786145 139215 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787767 139215 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
155564502 175258 None 0 Rat Functional pEC50 = 7 7.0 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4572408 175258 None 0 Rat Functional pEC50 = 7 7.0 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
11943 3873 None 0 Rat Functional pEC50 = 8.0 8.0 14 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
145925549 3873 None 0 Rat Functional pEC50 = 8.0 8.0 14 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL4438122 3873 None 0 Rat Functional pEC50 = 8.0 8.0 14 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155558059 174681 None 0 Human Functional pEC50 = 7.0 7.0 -5 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
CHEMBL4559239 174681 None 0 Human Functional pEC50 = 7.0 7.0 -5 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
155541440 173017 None 0 Rat Functional pEC50 = 7.9 7.9 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
CHEMBL4518530 173017 None 0 Rat Functional pEC50 = 7.9 7.9 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
155541295 173009 None 0 Rat Functional pEC50 = 7.9 7.9 4 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4518318 173009 None 0 Rat Functional pEC50 = 7.9 7.9 4 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155540639 172931 None 0 Rat Functional pEC50 = 5.9 5.9 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4516768 172931 None 0 Rat Functional pEC50 = 5.9 5.9 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL2028943 209133 None 0 Human Functional pEC50 = 6.8 6.8 -1 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155553930 175439 None 0 Rat Functional pEC50 = 4.8 4.8 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4576650 175439 None 0 Rat Functional pEC50 = 4.8 4.8 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155540033 172888 None 0 Human Functional pEC50 = 6.7 6.7 -2 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
CHEMBL4515768 172888 None 0 Human Functional pEC50 = 6.7 6.7 -2 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
127029977 139216 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786986 139216 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787768 139216 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
127029977 139216 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786986 139216 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787768 139216 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
127031545 139194 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787379 139194 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787701 139194 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
127031545 139194 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787379 139194 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787701 139194 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
16133225 419 None 52 Human Functional pEC50 = 8.6 8.6 -5 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
172198 419 None 52 Human Functional pEC50 = 8.6 8.6 -5 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
2504 419 None 52 Human Functional pEC50 = 8.6 8.6 -5 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
45266664 419 None 52 Human Functional pEC50 = 8.6 8.6 -5 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
5272 419 None 52 Human Functional pEC50 = 8.6 8.6 -5 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL408403 419 None 52 Human Functional pEC50 = 8.6 8.6 -5 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
DB11842 419 None 52 Human Functional pEC50 = 8.6 8.6 -5 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155541440 173017 None 0 Human Functional pEC50 = 8.6 8.6 1 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
CHEMBL4518530 173017 None 0 Human Functional pEC50 = 8.6 8.6 1 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
10533900 175967 None 8 Rat Functional pEC50 = 7.7 7.7 10 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL4588454 175967 None 8 Rat Functional pEC50 = 7.7 7.7 10 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
155556507 174484 None 0 Rat Functional pEC50 = 6.7 6.7 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4554466 174484 None 0 Rat Functional pEC50 = 6.7 6.7 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155563538 175298 None 0 Rat Functional pEC50 = 6.7 6.7 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
CHEMBL4573250 175298 None 0 Rat Functional pEC50 = 6.7 6.7 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
155559104 174804 None 0 Rat Functional pEC50 = 7.6 7.6 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4562270 174804 None 0 Rat Functional pEC50 = 7.6 7.6 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155554865 174352 None 0 Rat Functional pEC50 = 6.6 6.6 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4551317 174352 None 0 Rat Functional pEC50 = 6.6 6.6 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155540328 172899 None 0 Human Functional pEC50 = 6.6 6.6 -3 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
CHEMBL4516066 172899 None 0 Human Functional pEC50 = 6.6 6.6 -3 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
155553479 174176 None 0 Rat Functional pEC50 = 6.6 6.6 3 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4547423 174176 None 0 Rat Functional pEC50 = 6.6 6.6 3 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155558003 174691 None 0 Rat Functional pEC50 = 5.6 5.6 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4559421 174691 None 0 Rat Functional pEC50 = 5.6 5.6 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155547428 173613 None 0 Rat Functional pEC50 = 4.6 4.6 -22 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4533618 173613 None 0 Rat Functional pEC50 = 4.6 4.6 -22 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155566196 175744 None 0 Rat Functional pEC50 = 4.6 4.6 -5 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4583284 175744 None 0 Rat Functional pEC50 = 4.6 4.6 -5 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155558428 174727 None 0 Rat Functional pEC50 = 7.6 7.6 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4560224 174727 None 0 Rat Functional pEC50 = 7.6 7.6 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
11944 3874 None 0 Rat Functional pEC50 = 6.6 6.6 4 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155552190 3874 None 0 Rat Functional pEC50 = 6.6 6.6 4 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL4544228 3874 None 0 Rat Functional pEC50 = 6.6 6.6 4 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL77838 215876 None 5 Rat Functional pEC50 = 8.5 8.5 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O nan
155552475 174050 None 0 Human Functional pEC50 = 8.4 8.4 9 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4543860 174050 None 0 Human Functional pEC50 = 8.4 8.4 9 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155542907 173175 None 0 Rat Functional pEC50 = 6.5 6.5 3 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
CHEMBL4522038 173175 None 0 Rat Functional pEC50 = 6.5 6.5 3 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
CHEMBL2028943 209133 None 0 Rat Functional pEC50 = 7.5 7.5 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155552475 174050 None 0 Rat Functional pEC50 = 6.5 6.5 -9 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4543860 174050 None 0 Rat Functional pEC50 = 6.5 6.5 -9 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155556530 174509 None 0 Rat Functional pEC50 = 7.5 7.5 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
CHEMBL4555119 174509 None 0 Rat Functional pEC50 = 7.5 7.5 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
155561376 175673 None 0 Rat Functional pEC50 = 6.4 6.4 12 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O nan
CHEMBL4581718 175673 None 0 Rat Functional pEC50 = 6.4 6.4 12 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O nan
155541125 172963 None 0 Rat Functional pEC50 = 7.4 7.4 6 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
CHEMBL4517561 172963 None 0 Rat Functional pEC50 = 7.4 7.4 6 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
24892627 55651 None 5 Human Functional pEC50 = 4.2 4.2 -5 2
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 548 8 0 6 5.0 Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 nan
CHEMBL1460676 55651 None 5 Human Functional pEC50 = 4.2 4.2 -5 2
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 548 8 0 6 5.0 Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 nan
CHEMBL1621632 55651 None 5 Human Functional pEC50 = 4.2 4.2 -5 2
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 548 8 0 6 5.0 Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 nan
155558059 174681 None 0 Rat Functional pEC50 = 7.2 7.2 5 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
CHEMBL4559239 174681 None 0 Rat Functional pEC50 = 7.2 7.2 5 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
CHEMBL938 215905 None 28 Rat Functional pEC50 = 8.2 8.2 -10 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
CHEMBL312754 211108 None 18 Rat Functional pEC50 = 8.2 8.2 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
154573825 175987 None 9 Rat Functional pEC50 = 8.2 8.2 8 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
CHEMBL4588946 175987 None 9 Rat Functional pEC50 = 8.2 8.2 8 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
155560463 175038 None 0 Rat Functional pEC50 = 7.2 7.2 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
CHEMBL4567667 175038 None 0 Rat Functional pEC50 = 7.2 7.2 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
155553003 174074 None 0 Human Functional pEC50 = 7.2 7.2 1 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
CHEMBL4544308 174074 None 0 Human Functional pEC50 = 7.2 7.2 1 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
10533900 175967 None 8 Human Functional pEC50 = 6.2 6.2 -10 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL4588454 175967 None 8 Human Functional pEC50 = 6.2 6.2 -10 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL2392353 210412 None 6 Rat Functional pEC50 = 8.1 8.1 -50 3
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155553098 174108 None 0 Rat Functional pEC50 = 8.1 8.1 22 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4545153 174108 None 0 Rat Functional pEC50 = 8.1 8.1 22 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
1588251 59275 None 10 Human Functional pEC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 436 4 0 5 5.8 CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O nan
CHEMBL1704271 59275 None 10 Human Functional pEC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 436 4 0 5 5.8 CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O nan
155540328 172899 None 0 Rat Functional pEC50 = 7.1 7.1 3 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
CHEMBL4516066 172899 None 0 Rat Functional pEC50 = 7.1 7.1 3 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
155540033 172888 None 0 Rat Functional pEC50 = 7.1 7.1 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
CHEMBL4515768 172888 None 0 Rat Functional pEC50 = 7.1 7.1 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
155539838 172893 None 0 Rat Functional pEC50 = 8.1 8.1 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4515848 172893 None 0 Rat Functional pEC50 = 8.1 8.1 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL2370909 209946 None 0 Rat Functional pEC50 = 7.0 7.0 7 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155558784 174774 None 0 Rat Functional pEC50 = 6.0 6.0 -2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4561366 174774 None 0 Rat Functional pEC50 = 6.0 6.0 -2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
154573825 175987 None 9 Human Functional pEC50 = 7.0 7.0 -8 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
CHEMBL4588946 175987 None 9 Human Functional pEC50 = 7.0 7.0 -8 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
155553003 174074 None 0 Rat Functional pEC50 = 7.0 7.0 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
CHEMBL4544308 174074 None 0 Rat Functional pEC50 = 7.0 7.0 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
3025727 184078 None 10 Rabbit Functional pIC50 = 10.3 10.3 10000 2
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL48242 184078 None 10 Rabbit Functional pIC50 = 10.3 10.3 10000 2
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
14971704 112383 None 0 Rabbit Functional pIC50 = 9.7 9.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL329616 112383 None 0 Rabbit Functional pIC50 = 9.7 9.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
133031 100857 None 21 Human Functional pIC50 = 9.7 9.7 1 3
Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm1013693
CHEMBL293511 100857 None 21 Human Functional pIC50 = 9.7 9.7 1 3
Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm1013693
9892554 100192 None 6 Rabbit Functional pIC50 = 9.7 9.7 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 510 9 1 8 3.5 CCCCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL288246 100192 None 6 Rabbit Functional pIC50 = 9.7 9.7 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 510 9 1 8 3.5 CCCCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
14971715 168234 None 0 Rabbit Functional pIC50 = 9.7 9.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 492 10 2 6 5.4 CCCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL433646 168234 None 0 Rabbit Functional pIC50 = 9.7 9.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 492 10 2 6 5.4 CCCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971716 14522 None 0 Rabbit Functional pIC50 = 9.6 9.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 11 2 6 5.6 CCCCc1nn(CCc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120199 14522 None 0 Rabbit Functional pIC50 = 9.6 9.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 11 2 6 5.6 CCCCc1nn(CCc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971706 207207 None 0 Rabbit Functional pIC50 = 9.6 9.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL92654 207207 None 0 Rabbit Functional pIC50 = 9.6 9.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
183134 204842 None 17 Human Functional pIC50 = 9.5 9.5 -4 7
Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm1013693
CHEMBL7550 204842 None 17 Human Functional pIC50 = 9.5 9.5 -4 7
Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm1013693
14971698 207291 None 0 Rabbit Functional pIC50 = 9.5 9.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL93226 207291 None 0 Rabbit Functional pIC50 = 9.5 9.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
9827346 99735 None 4 Human Functional pIC50 = 9.4 9.4 1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 10.1016/j.bmc.2010.10.043
CHEMBL284918 99735 None 4 Human Functional pIC50 = 9.4 9.4 1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 10.1016/j.bmc.2010.10.043
CHEMBL34866 99735 None 4 Human Functional pIC50 = 9.4 9.4 1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 10.1016/j.bmc.2010.10.043
9870652 70890 None 75 Rabbit Functional pIC50 = 9.4 9.4 15 2
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951143 70890 None 75 Rabbit Functional pIC50 = 9.4 9.4 15 2
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
DB09279 70890 None 75 Rabbit Functional pIC50 = 9.4 9.4 15 2
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971720 114820 None 0 Rabbit Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 478 9 2 6 5.0 CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL334145 114820 None 0 Rabbit Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 478 9 2 6 5.0 CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
14971720 114820 None 0 Rabbit Functional pIC50 = 9.4 9.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 478 9 2 6 5.0 CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL334145 114820 None 0 Rabbit Functional pIC50 = 9.4 9.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 478 9 2 6 5.0 CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971705 206747 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 492 9 2 6 5.7 CCCCc1nn(-c2ccccc2C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL90011 206747 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 492 9 2 6 5.7 CCCCc1nn(-c2ccccc2C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10325927 206884 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 580 9 2 6 7.3 CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL90774 206884 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 580 9 2 6 7.3 CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971714 99188 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 484 9 2 6 4.9 CCCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL281386 99188 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 484 9 2 6 4.9 CCCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
183134 204842 None 17 Rabbit Functional pIC50 = 9.3 9.3 -2 7
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00078a013
183134 204842 None 17 Rabbit Functional pIC50 = 9.3 9.3 -2 7
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00078a014
CHEMBL7550 204842 None 17 Rabbit Functional pIC50 = 9.3 9.3 -2 7
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00078a013
CHEMBL7550 204842 None 17 Rabbit Functional pIC50 = 9.3 9.3 -2 7
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00078a014
14971639 114130 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL332897 114130 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
14971639 114130 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL332897 114130 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971702 207177 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL92472 207177 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971710 207396 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 554 10 2 6 7.0 CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL93886 207396 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 554 10 2 6 7.0 CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971717 14580 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 532 8 2 6 6.0 CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120457 14580 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 532 8 2 6 6.0 CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10369813 116978 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 532 8 2 6 6.3 CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL338740 116978 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 532 8 2 6 6.3 CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
142534045 166476 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 543 9 1 7 4.9 CCCCc1nc(C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4278280 166476 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 543 9 1 7 4.9 CCCCc1nc(C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14956763 163395 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 526 10 1 10 4.2 CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL419483 163395 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 526 10 1 10 4.2 CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971701 207417 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL94002 207417 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971708 114592 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 508 10 2 7 5.4 CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL333800 114592 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 508 10 2 7 5.4 CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10393717 116097 None 0 Rabbit Functional pIC50 = 9.1 9.1 524 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 595 11 1 7 6.1 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
CHEMBL335722 116097 None 0 Rabbit Functional pIC50 = 9.1 9.1 524 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 595 11 1 7 6.1 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
9914666 116668 None 0 Rabbit Functional pIC50 = 9.1 9.1 3388 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1021/jm00078a013
CHEMBL337086 116668 None 0 Rabbit Functional pIC50 = 9.1 9.1 3388 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1021/jm00078a013
14956739 206300 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87074 206300 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
192567 116650 None 6 Rabbit Functional pIC50 = 9.1 9.1 223 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 581 10 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL337007 116650 None 6 Rabbit Functional pIC50 = 9.1 9.1 223 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 581 10 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 10.1021/jm00078a014
10140613 106094 None 0 Rabbit Functional pIC50 = 9.1 9.1 3 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 10 1 7 4.5 CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313371 106094 None 0 Rabbit Functional pIC50 = 9.1 9.1 3 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 10 1 7 4.5 CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956772 105945 None 0 Rabbit Functional pIC50 = 9.0 9.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 510 10 1 9 4.6 CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL312913 105945 None 0 Rabbit Functional pIC50 = 9.0 9.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 510 10 1 9 4.6 CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
192345 26234 None 6 Rabbit Functional pIC50 = 9 9.0 12022 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 496 6 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
CHEMBL135775 26234 None 6 Rabbit Functional pIC50 = 9 9.0 12022 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 496 6 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
10326140 116649 None 0 Rabbit Functional pIC50 = 9 9.0 2884 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 593 11 1 7 5.9 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
CHEMBL337006 116649 None 0 Rabbit Functional pIC50 = 9 9.0 2884 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 593 11 1 7 5.9 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
9807766 70882 None 0 Rabbit Functional pIC50 = 9.0 9.0 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 555 9 1 8 4.0 CCCCc1nc(C)c(CC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951136 70882 None 0 Rabbit Functional pIC50 = 9.0 9.0 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 555 9 1 8 4.0 CCCCc1nc(C)c(CC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
60770 169497 None 17 Rabbit Functional pIC50 = 9.0 9.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 8 2 6 5.1 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL443269 169497 None 17 Rabbit Functional pIC50 = 9.0 9.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 8 2 6 5.1 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
142534141 167175 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 557 9 1 7 5.3 CCCCc1nc(C)c(CC(=S)N2CCCC2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4291216 167175 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 557 9 1 7 5.3 CCCCc1nc(C)c(CC(=S)N2CCCC2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14956757 67591 None 0 Rabbit Functional pIC50 = 8.9 8.9 831 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL19018 67591 None 0 Rabbit Functional pIC50 = 8.9 8.9 831 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971700 207455 None 0 Rabbit Functional pIC50 = 8.9 8.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL94221 207455 None 0 Rabbit Functional pIC50 = 8.9 8.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
9871638 70891 None 0 Rabbit Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 529 11 1 7 5.0 CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951144 70891 None 0 Rabbit Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 529 11 1 7 5.0 CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
44320012 167921 None 0 Rabbit Functional pIC50 = 8.9 8.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 9 1 7 5.4 CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL431411 167921 None 0 Rabbit Functional pIC50 = 8.9 8.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 9 1 7 5.4 CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
155542482 173125 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 487 9 1 6 5.5 CCCCC1=NC(C)=C(CC(=S)N(C)C)CN1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2018.12.043
CHEMBL4520827 173125 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 487 9 1 6 5.5 CCCCC1=NC(C)=C(CC(=S)N(C)C)CN1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2018.12.043
44213341 70875 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 511 9 1 7 4.0 CCCCc1nc(C)c(CC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951129 70875 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 511 9 1 7 4.0 CCCCc1nc(C)c(CC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
137532858 167088 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 517 9 1 7 4.4 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4289788 167088 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 517 9 1 7 4.4 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14971719 114790 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 470 8 2 6 4.5 CCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL333978 114790 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 470 8 2 6 4.5 CCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971711 16552 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 479 9 2 7 4.7 CCCCc1nn(-c2ccccn2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL123767 16552 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 479 9 2 7 4.7 CCCCc1nn(-c2ccccn2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971707 207334 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 523 10 2 8 5.3 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL93547 207334 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 523 10 2 8 5.3 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
44213349 70881 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 527 9 1 8 3.2 CCCCc1nc(C)c(CC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951135 70881 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 527 9 1 8 3.2 CCCCc1nc(C)c(CC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
20081627 92168 None 0 Human Functional pIC50 = 8.7 8.7 1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 502 6 2 7 4.7 CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/j.bmc.2010.10.043
CHEMBL24224 92168 None 0 Human Functional pIC50 = 8.7 8.7 1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 502 6 2 7 4.7 CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/j.bmc.2010.10.043
145981239 166607 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 571 9 1 7 5.7 CCCCc1nc(C)c(CC(=S)N2[C@H](C)CC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4280574 166607 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 571 9 1 7 5.7 CCCCc1nc(C)c(CC(=S)N2[C@H](C)CC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
131654 206401 None 12 Rabbit Functional pIC50 = 8.7 8.7 1 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87778 206401 None 12 Rabbit Functional pIC50 = 8.7 8.7 1 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956781 206171 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 443 8 1 7 4.4 CCCCc1nn(C2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86314 206171 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 443 8 1 7 4.4 CCCCc1nn(C2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
9845644 206431 None 0 Rabbit Functional pIC50 = 8.7 8.7 5 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 9 1 7 4.3 CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87964 206431 None 0 Rabbit Functional pIC50 = 8.7 8.7 5 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 9 1 7 4.3 CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1610 2345 None 95 Rabbit Functional pIC50 = 8 8.0 -19 11
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
3941 2345 None 95 Rabbit Functional pIC50 = 8 8.0 -19 11
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
3961 2345 None 95 Rabbit Functional pIC50 = 8 8.0 -19 11
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
590 2345 None 95 Rabbit Functional pIC50 = 8 8.0 -19 11
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
CHEMBL191 2345 None 95 Rabbit Functional pIC50 = 8 8.0 -19 11
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
DB00678 2345 None 95 Rabbit Functional pIC50 = 8 8.0 -19 11
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
10095589 115517 None 0 Rabbit Functional pIC50 = 8 8.0 851 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL335289 115517 None 0 Rabbit Functional pIC50 = 8 8.0 851 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
19939399 106162 None 0 Rabbit Functional pIC50 = 8 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 609 11 2 10 5.2 CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313696 106162 None 0 Rabbit Functional pIC50 = 8 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 609 11 2 10 5.2 CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10222835 206143 None 0 Rabbit Functional pIC50 = 8 8.0 2 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 403 8 1 7 3.3 CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86084 206143 None 0 Rabbit Functional pIC50 = 8 8.0 2 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 403 8 1 7 3.3 CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
142533975 167046 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by beta-arrestin recruitment assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by beta-arrestin recruitment assay
ChEMBL 571 10 1 7 5.7 CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4288964 167046 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by beta-arrestin recruitment assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by beta-arrestin recruitment assay
ChEMBL 571 10 1 7 5.7 CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
44348352 16526 None 0 Rabbit Functional pIC50 = 7 7.0 1 2
Antagonist activity at angiotensin AT1 receptor in rabbit adrenal cortex assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit adrenal cortex assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 459 8 1 6 4.5 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC 10.1016/j.bmc.2010.10.043
CHEMBL123713 16526 None 0 Rabbit Functional pIC50 = 7 7.0 1 2
Antagonist activity at angiotensin AT1 receptor in rabbit adrenal cortex assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit adrenal cortex assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 459 8 1 6 4.5 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC 10.1016/j.bmc.2010.10.043
14971675 206967 None 0 Rabbit Functional pIC50 = 7 7.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL91287 206967 None 0 Rabbit Functional pIC50 = 7 7.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10048220 26187 None 0 Rabbit Functional pIC50 = 7 7.0 109 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 428 7 2 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL135704 26187 None 0 Rabbit Functional pIC50 = 7 7.0 109 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 428 7 2 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
14956760 165498 None 0 Rabbit Functional pIC50 = 7 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 466 8 2 8 3.9 CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL424053 165498 None 0 Rabbit Functional pIC50 = 7 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 466 8 2 8 3.9 CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956777 206327 None 0 Rabbit Functional pIC50 = 7 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 415 8 1 7 3.6 CCCCc1nn(C2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87276 206327 None 0 Rabbit Functional pIC50 = 7 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 415 8 1 7 3.6 CCCCc1nn(C2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
164611301 185016 None 0 Human Functional pIC50 = 5 5.0 -1 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 416 7 1 5 3.9 CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 10.1021/acsmedchemlett.1c00240
CHEMBL4854916 185016 None 0 Human Functional pIC50 = 5 5.0 -1 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 416 7 1 5 3.9 CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 10.1021/acsmedchemlett.1c00240
1240113 29468 None 7 Human Functional pIC50 = 5 5.0 -3 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 265 3 0 2 4.8 Cc1cccc(CSc2cccc3cccnc23)c1 nan
CHEMBL1384550 29468 None 7 Human Functional pIC50 = 5 5.0 -3 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 265 3 0 2 4.8 Cc1cccc(CSc2cccc3cccnc23)c1 nan
164622816 185872 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 416 7 1 5 3.9 CCCC[C@@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@@H]2CCCN21 10.1021/acsmedchemlett.1c00240
CHEMBL4868159 185872 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 416 7 1 5 3.9 CCCC[C@@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@@H]2CCCN21 10.1021/acsmedchemlett.1c00240
5411796 71925 None 9 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 335 4 1 3 3.9 O=C(N/N=C(\c1ccccc1)c1ccccn1)c1ccccc1Cl nan
CHEMBL1972216 71925 None 9 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 335 4 1 3 3.9 O=C(N/N=C(\c1ccccc1)c1ccccn1)c1ccccc1Cl nan
5740287 40193 None 8 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 394 6 0 7 4.3 COc1cc(/C=C/c2ccc3cccc(OC)c3n2)c(OC(C)=O)c([N+](=O)[O-])c1 nan
CHEMBL1480264 40193 None 8 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 394 6 0 7 4.3 COc1cc(/C=C/c2ccc3cccc(OC)c3n2)c(OC(C)=O)c([N+](=O)[O-])c1 nan
5738419 48452 None 14 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 253 2 1 3 4.2 Oc1cccc2ccc(/C=C/c3cccs3)nc12 nan
CHEMBL1555793 48452 None 14 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 253 2 1 3 4.2 Oc1cccc2ccc(/C=C/c3cccs3)nc12 nan
659124 38435 None 8 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 7 1 7 4.4 CCCCn1c(NC(=O)c2ccco2)c(C(=O)OCC)c2nc3ccccc3nc21 nan
CHEMBL1463829 38435 None 8 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 7 1 7 4.4 CCCCn1c(NC(=O)c2ccco2)c(C(=O)OCC)c2nc3ccccc3nc21 nan
1183382 23503 None 15 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 367 5 0 7 3.3 COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cc2ccccc2oc1=O nan
CHEMBL1333737 23503 None 15 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 367 5 0 7 3.3 COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cc2ccccc2oc1=O nan
1334532 36924 None 7 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 365 2 3 4 3.0 Cc1cc(O)ccc1NC(=S)NC(=O)c1cncc(Br)c1 nan
CHEMBL1451169 36924 None 7 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 365 2 3 4 3.0 Cc1cc(O)ccc1NC(=S)NC(=O)c1cncc(Br)c1 nan
10257526 112370 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL329541 112370 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
5952109 72044 None 7 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 389 4 1 5 5.6 CC(=O)/C(=N\Nc1ccc(Cl)cc1Cl)Sc1cccc2cccnc12 nan
CHEMBL1976317 72044 None 7 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 389 4 1 5 5.6 CC(=O)/C(=N\Nc1ccc(Cl)cc1Cl)Sc1cccc2cccnc12 nan
2236648 28703 None 11 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 355 2 3 3 3.0 CC(C)(C)C(=O)NC(=S)NNC(=O)c1ccc(-c2ccccc2)cc1 nan
CHEMBL1377849 28703 None 11 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 355 2 3 3 3.0 CC(C)(C)C(=O)NC(=S)NNC(=O)c1ccc(-c2ccccc2)cc1 nan
6154033 108479 None 5 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 4 1 3 3.4 O=C(N/N=C(\c1ccccc1)c1cccnc1)c1cccc(F)c1 nan
CHEMBL3199403 108479 None 5 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 4 1 3 3.4 O=C(N/N=C(\c1ccccc1)c1cccnc1)c1cccc(F)c1 nan
4116022 50993 None 6 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 368 10 1 9 3.4 CCCSc1cc(NCCOC(=O)CCC)c([N+](=O)[O-])c2nonc12 nan
CHEMBL1578324 50993 None 6 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 368 10 1 9 3.4 CCCSc1cc(NCCOC(=O)CCC)c([N+](=O)[O-])c2nonc12 nan
19939367 105948 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL312921 105948 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956804 105997 None 0 Rabbit Functional pIC50 = 8.0 8.0 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 11 1 7 4.9 CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313222 105997 None 0 Rabbit Functional pIC50 = 8.0 8.0 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 11 1 7 4.9 CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956792 106764 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314447 106764 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956754 157383 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 541 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL407827 157383 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 541 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956787 206345 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 461 9 1 9 3.0 CCCCc1nn(C(C)C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87363 206345 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 461 9 1 9 3.0 CCCCc1nn(C(C)C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44373246 168265 None 0 Bovine Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic potency against Angiotensin II receptor, type 1 in rat adrenal cortexIn vitro antagonistic potency against Angiotensin II receptor, type 1 in rat adrenal cortex
ChEMBL 435 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 10.1021/jm9504722
CHEMBL433895 168265 None 0 Bovine Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic potency against Angiotensin II receptor, type 1 in rat adrenal cortexIn vitro antagonistic potency against Angiotensin II receptor, type 1 in rat adrenal cortex
ChEMBL 435 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 10.1021/jm9504722
14956796 205797 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL83182 205797 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10094520 24756 None 0 Rabbit Functional pIC50 = 6.0 6.0 11 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C 10.1021/jm00078a013
CHEMBL134433 24756 None 0 Rabbit Functional pIC50 = 6.0 6.0 11 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C 10.1021/jm00078a013
3504072 33628 None 12 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 299 2 2 3 2.1 O=C(NNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccn1 nan
CHEMBL1421427 33628 None 12 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 299 2 2 3 2.1 O=C(NNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccn1 nan
869765 38586 None 8 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 322 5 2 6 3.1 COc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1OC nan
CHEMBL1464917 38586 None 8 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 322 5 2 6 3.1 COc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1OC nan
16446215 47605 None 9 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 467 7 1 6 4.3 Cc1ccc(CS(=O)(=O)c2ncc(Cl)c(C(=O)Nc3ccc(OC(F)F)cc3)n2)cc1 nan
CHEMBL1546607 47605 None 9 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 467 7 1 6 4.3 Cc1ccc(CS(=O)(=O)c2ncc(Cl)c(C(=O)Nc3ccc(OC(F)F)cc3)n2)cc1 nan
5295671 35514 None 10 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 314 2 0 6 2.1 CC(=O)C1=C(c2ccccc2)N(C(C)=O)n2c(C)nnc2S1 nan
CHEMBL1438779 35514 None 10 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 314 2 0 6 2.1 CC(=O)C1=C(c2ccccc2)N(C(C)=O)n2c(C)nnc2S1 nan
1653161 40323 None 13 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 3 3 5 1.2 COc1ccccc1C(=O)NNC(=S)NC(=O)c1ccco1 nan
CHEMBL1481281 40323 None 13 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 3 3 5 1.2 COc1ccccc1C(=O)NNC(=S)NC(=O)c1ccco1 nan
14956759 206100 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 495 9 2 8 4.0 CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85704 206100 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 495 9 2 8 4.0 CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
5335659 108461 None 7 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 257 3 1 3 2.4 C/C(=N\NC(=O)c1ccccc1F)c1ccccn1 nan
CHEMBL3199216 108461 None 7 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 257 3 1 3 2.4 C/C(=N\NC(=O)c1ccccc1F)c1ccccn1 nan
16446684 42993 None 9 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 405 5 1 5 3.5 O=C(Nc1ccc(F)cc1)c1nc(S(=O)(=O)Cc2ccccc2)ncc1Cl nan
CHEMBL1504077 42993 None 9 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 405 5 1 5 3.5 O=C(Nc1ccc(F)cc1)c1nc(S(=O)(=O)Cc2ccccc2)ncc1Cl nan
2426231 38121 None 6 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 394 3 3 3 5.3 Cc1c(Cl)cccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl nan
CHEMBL1461119 38121 None 6 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 394 3 3 3 5.3 Cc1c(Cl)cccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl nan
53319274 57598 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cellsAntagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cells
ChEMBL 559 9 1 7 4.2 CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O 10.1016/j.bmc.2010.10.043
CHEMBL1668000 57598 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cellsAntagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cells
ChEMBL 559 9 1 7 4.2 CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O 10.1016/j.bmc.2010.10.043
10027714 115435 None 0 Rabbit Functional pIC50 = 7.9 7.9 398 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 9 1 5 6.0 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL335066 115435 None 0 Rabbit Functional pIC50 = 7.9 7.9 398 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 9 1 5 6.0 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
14956793 206306 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87129 206306 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956791 206339 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 459 8 2 8 3.4 CCCCc1nn(C2CCCC2O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87341 206339 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 459 8 2 8 3.4 CCCCc1nn(C2CCCC2O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956798 206407 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.0 CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87798 206407 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.0 CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14951059 206427 None 0 Rabbit Functional pIC50 = 7.9 7.9 -1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 10 1 8 4.2 CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87942 206427 None 0 Rabbit Functional pIC50 = 7.9 7.9 -1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 10 1 8 4.2 CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
11744670 115252 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 453 5 0 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2C#N)c1 10.1021/jm00078a013
CHEMBL334775 115252 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 453 5 0 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2C#N)c1 10.1021/jm00078a013
14956742 206326 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87275 206326 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
5187118 51860 None 6 Human Functional pIC50 = 4.9 4.9 -5 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 338 3 1 3 4.8 Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 nan
CHEMBL1585527 51860 None 6 Human Functional pIC50 = 4.9 4.9 -5 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 338 3 1 3 4.8 Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 nan
2313746 52118 None 1 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 333 4 4 7 0.6 O=C1OCC(CO)(CO)N=C1NNc1cc(Cl)ccc1Cl nan
CHEMBL1587672 52118 None 1 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 333 4 4 7 0.6 O=C1OCC(CO)(CO)N=C1NNc1cc(Cl)ccc1Cl nan
6917582 45671 None 1 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 378 3 1 5 3.1 COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 nan
CHEMBL1529805 45671 None 1 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 378 3 1 5 3.1 COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 nan
665535 44992 None 6 Human Functional pIC50 = 4.9 4.9 -1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 425 7 1 9 1.8 COC(=O)CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 nan
CHEMBL1523699 44992 None 6 Human Functional pIC50 = 4.9 4.9 -1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 425 7 1 9 1.8 COC(=O)CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 nan
2812568 37205 None 5 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 286 3 2 3 3.8 O=C(NNc1ccc(Cl)cc1)c1sccc1Cl nan
CHEMBL1453309 37205 None 5 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 286 3 2 3 3.8 O=C(NNc1ccc(Cl)cc1)c1sccc1Cl nan
921731 52174 None 7 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 321 5 0 7 2.1 O=C(COC(=O)c1cnccn1)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1588194 52174 None 7 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 321 5 0 7 2.1 O=C(COC(=O)c1cnccn1)c1ccc(Cl)c([N+](=O)[O-])c1 nan
6173110 108158 None 4 Human Functional pIC50 = 4.9 4.9 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 331 5 1 4 3.3 COc1cccc(C(=O)N/N=C(/c2ccccc2)c2ccccn2)c1 nan
CHEMBL3196139 108158 None 4 Human Functional pIC50 = 4.9 4.9 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 331 5 1 4 3.3 COc1cccc(C(=O)N/N=C(/c2ccccc2)c2ccccn2)c1 nan
2351493 49783 None 2 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 301 4 1 3 3.3 O=C(NN=C(c1ccccc1)c1ccccn1)c1ccccc1 nan
CHEMBL1567294 49783 None 2 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 301 4 1 3 3.3 O=C(NN=C(c1ccccc1)c1ccccn1)c1ccccc1 nan
11467216 122600 None 0 Rabbit Functional pIC50 = 5.9 5.9 - 1
Vasorelaxing potency was determinedVasorelaxing potency was determined
ChEMBL 567 15 1 10 5.2 CCCCc1nc(Cl)c(COC(=O)CCCCO[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm049681p
CHEMBL360220 122600 None 0 Rabbit Functional pIC50 = 5.9 5.9 - 1
Vasorelaxing potency was determinedVasorelaxing potency was determined
ChEMBL 567 15 1 10 5.2 CCCCc1nc(Cl)c(COC(=O)CCCCO[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm049681p
135457059 51013 None 23 Human Functional pIC50 = 4.9 4.9 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 329 4 1 5 4.2 Oc1cc(CSc2ccc(Cl)cc2)nc(-c2ccccn2)n1 nan
CHEMBL1578482 51013 None 23 Human Functional pIC50 = 4.9 4.9 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 329 4 1 5 4.2 Oc1cc(CSc2ccc(Cl)cc2)nc(-c2ccccn2)n1 nan
2303647 28424 None 10 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 262 3 2 4 3.1 NNc1nc(-c2ccccc2)cc(-c2ccccc2)n1 nan
CHEMBL1375248 28424 None 10 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 262 3 2 4 3.1 NNc1nc(-c2ccccc2)cc(-c2ccccc2)n1 nan
11328757 205965 None 0 Rabbit Functional pIC50 = 7.9 7.9 -1 2
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 464 6 1 5 6.3 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 10.1021/jm0603163
CHEMBL84573 205965 None 0 Rabbit Functional pIC50 = 7.9 7.9 -1 2
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 464 6 1 5 6.3 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 10.1021/jm0603163
9896251 98771 None 0 Human Functional pIC50 = 7.9 7.9 1 3
Antagonist activity at type 1 angiotensin 2 receptorAntagonist activity at type 1 angiotensin 2 receptor
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/j.bmc.2012.06.011
CHEMBL278176 98771 None 0 Human Functional pIC50 = 7.9 7.9 1 3
Antagonist activity at type 1 angiotensin 2 receptorAntagonist activity at type 1 angiotensin 2 receptor
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/j.bmc.2012.06.011
9958963 207230 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2ccccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL92821 207230 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2ccccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971680 207369 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 520 10 1 7 6.1 CCCCc1nn(-c2ccccc2C)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL93735 207369 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 520 10 1 7 6.1 CCCCc1nn(-c2ccccc2C)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
57391456 70889 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 569 10 1 8 4.4 CCCCc1nc(C)c(CCC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951142 70889 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 569 10 1 8 4.4 CCCCc1nc(C)c(CCC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971687 14811 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 430 9 2 6 4.4 CCCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120716 14811 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 430 9 2 6 4.4 CCCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956812 106670 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 463 8 1 7 4.1 O=c1n(CCc2ccccc2)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314333 106670 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 463 8 1 7 4.1 O=c1n(CCc2ccccc2)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
793621 26578 None 8 Human Functional pIC50 = 4.9 4.9 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 281 1 1 5 3.3 CC1=NC(Nc2nc(C)c3ccccc3n2)=NC(C)(C)C1 nan
CHEMBL1361034 26578 None 8 Human Functional pIC50 = 4.9 4.9 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 281 1 1 5 3.3 CC1=NC(Nc2nc(C)c3ccccc3n2)=NC(C)(C)C1 nan
2420694 33048 None 6 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 360 3 3 3 4.8 Cc1cccc(NC(S)=NNc2ncc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL1416497 33048 None 6 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 360 3 3 3 4.8 Cc1cccc(NC(S)=NNc2ncc(C(F)(F)F)cc2Cl)c1 nan
1477595 44657 None 29 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 264 3 0 5 1.8 O=[N+]([O-])c1ccc(S(=O)(=O)c2ccccc2)nc1 nan
CHEMBL1520753 44657 None 29 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 264 3 0 5 1.8 O=[N+]([O-])c1ccc(S(=O)(=O)c2ccccc2)nc1 nan
1336836 33007 None 10 Human Functional pIC50 = 4.9 4.9 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 398 5 0 6 4.5 Cc1ccc2nc(C)cc(C(=O)OCC(=O)c3ccc(Cl)c([N+](=O)[O-])c3)c2c1 nan
CHEMBL1416155 33007 None 10 Human Functional pIC50 = 4.9 4.9 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 398 5 0 6 4.5 Cc1ccc2nc(C)cc(C(=O)OCC(=O)c3ccc(Cl)c([N+](=O)[O-])c3)c2c1 nan
135489943 107864 None 3 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 387 9 2 5 4.0 CCCCN(CCCC)C(=S)N/N=C/c1c(C)nn(-c2ccccc2)c1O nan
CHEMBL3192625 107864 None 3 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 387 9 2 5 4.0 CCCCN(CCCC)C(=S)N/N=C/c1c(C)nn(-c2ccccc2)c1O nan
1139588 38359 None 11 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 363 5 0 6 3.2 O=C(Cn1nnc2ccccc21)OCC(=O)c1ccc(Cl)c(Cl)c1 nan
CHEMBL1463168 38359 None 11 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 363 5 0 6 3.2 O=C(Cn1nnc2ccccc21)OCC(=O)c1ccc(Cl)c(Cl)c1 nan
6873170 108463 None 8 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 249 2 1 3 1.2 S=C(N/N=C/c1ccccc1)N1CCOCC1 nan
CHEMBL3199234 108463 None 8 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 249 2 1 3 1.2 S=C(N/N=C/c1ccccc1)N1CCOCC1 nan
804442 53825 None 56 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 289 4 1 2 3.7 O=C(CNc1ccc(Br)cc1)c1ccccc1 nan
CHEMBL1604367 53825 None 56 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 289 4 1 2 3.7 O=C(CNc1ccc(Br)cc1)c1ccccc1 nan
929469 46560 None 9 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 5 0 7 1.4 O=C(COC(=O)c1cnccn1)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1537991 46560 None 9 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 5 0 7 1.4 O=C(COC(=O)c1cnccn1)c1cccc([N+](=O)[O-])c1 nan
3244543 199494 None 25 Human Functional pIC50 = 4.9 4.9 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 188 0 2 3 2.1 Cc1cc(C)c2ccc(N)nc2c1O nan
CHEMBL591834 199494 None 25 Human Functional pIC50 = 4.9 4.9 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 188 0 2 3 2.1 Cc1cc(C)c2ccc(N)nc2c1O nan
43001 52783 None 26 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 230 1 1 4 2.0 Nc1c(N2CCCC2)c2ccccc2oc1=O nan
CHEMBL1594894 52783 None 26 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 230 1 1 4 2.0 Nc1c(N2CCCC2)c2ccccc2oc1=O nan
788616 53072 None 8 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 269 5 1 4 2.8 COC(=O)c1ccc(NCC(=O)c2ccccc2)cc1 nan
CHEMBL1597563 53072 None 8 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 269 5 1 4 2.8 COC(=O)c1ccc(NCC(=O)c2ccccc2)cc1 nan
2998385 25152 None 1 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 381 8 1 6 2.7 CC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 nan
CHEMBL1347643 25152 None 1 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 381 8 1 6 2.7 CC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 nan
9549748 23237 None 8 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 1 1 1 4.4 SC1=NCCc2ccccc2C1c1ccccc1Cl nan
CHEMBL1331656 23237 None 8 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 1 1 1 4.4 SC1=NCCc2ccccc2C1c1ccccc1Cl nan
2939261 22113 None 6 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 329 4 3 4 3.4 CCC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 nan
CHEMBL1322052 22113 None 6 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 329 4 3 4 3.4 CCC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 nan
14956799 106897 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314590 106897 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956766 106977 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 471 7 1 7 4.5 CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315128 106977 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 471 7 1 7 4.5 CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956813 206337 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 477 9 1 7 4.1 O=c1n(CCc2ccccc2)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87330 206337 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 477 9 1 7 4.1 O=c1n(CCc2ccccc2)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44211606 101211 None 0 Bovine Functional pIC50 = 6.9 6.9 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 591 10 1 10 5.2 CCCCc1nc2ccc(C3(C)CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL295905 101211 None 0 Bovine Functional pIC50 = 6.9 6.9 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 591 10 1 10 5.2 CCCCc1nc2ccc(C3(C)CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
44246747 55835 None 0 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 429 3 2 5 3.2 O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 nan
CHEMBL1521291 55835 None 0 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 429 3 2 5 3.2 O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 nan
CHEMBL1623128 55835 None 0 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 429 3 2 5 3.2 O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 nan
135501733 37058 None 17 Human Functional pIC50 = 4.9 4.9 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 336 3 2 5 2.4 Cc1nc(-n2nc3c(c2O)CCCC3)[nH]c(=O)c1Cc1ccccc1 nan
CHEMBL1452116 37058 None 17 Human Functional pIC50 = 4.9 4.9 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 336 3 2 5 2.4 Cc1nc(-n2nc3c(c2O)CCCC3)[nH]c(=O)c1Cc1ccccc1 nan
2898747 36764 None 12 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 418 6 0 7 1.8 O=C(CN1C(=O)C2C3C=CC(C3)C2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1449757 36764 None 12 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 418 6 0 7 1.8 O=C(CN1C(=O)C2C3C=CC(C3)C2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
788619 45565 None 10 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 4 1 2 4.3 Cc1ccc(C)c(NCC(=O)c2ccc(Cl)cc2)c1 nan
CHEMBL1528883 45565 None 10 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 4 1 2 4.3 Cc1ccc(C)c(NCC(=O)c2ccc(Cl)cc2)c1 nan
3648468 51505 None 8 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 373 4 1 3 4.6 O=C(CNc1ccc(Br)cc1)c1ccc(Br)s1 nan
CHEMBL1582697 51505 None 8 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 373 4 1 3 4.6 O=C(CNc1ccc(Br)cc1)c1ccc(Br)s1 nan
135419079 30224 None 7 Human Functional pIC50 = 4.8 4.8 -1 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 340 2 2 5 4.0 Cc1[nH]c2ccccc2c1/C=C1\SC(=N)N(c2nccs2)C1=O nan
CHEMBL1390716 30224 None 7 Human Functional pIC50 = 4.8 4.8 -1 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 340 2 2 5 4.0 Cc1[nH]c2ccccc2c1/C=C1\SC(=N)N(c2nccs2)C1=O nan
877472 36674 None 8 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 323 4 1 2 4.4 O=C(CNc1cccc(Cl)c1)c1ccc(Br)cc1 nan
CHEMBL1449035 36674 None 8 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 323 4 1 2 4.4 O=C(CNc1cccc(Cl)c1)c1ccc(Br)cc1 nan
902793 43211 None 18 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 4 0 4 3.4 O=C(COC(=O)c1ccncc1)c1ccc(Cl)c(Cl)c1 nan
CHEMBL1505893 43211 None 18 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 4 0 4 3.4 O=C(COC(=O)c1ccncc1)c1ccc(Cl)c(Cl)c1 nan
67903280 186200 None 0 Human Functional pIC50 = 7.8 7.8 4 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 430 8 1 5 4.9 CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL4872989 186200 None 0 Human Functional pIC50 = 7.8 7.8 4 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 430 8 1 5 4.9 CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
44355662 26460 None 0 Rabbit Functional pIC50 = 7.8 7.8 125 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 506 6 1 5 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 10.1021/jm00078a013
CHEMBL135999 26460 None 0 Rabbit Functional pIC50 = 7.8 7.8 125 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 506 6 1 5 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 10.1021/jm00078a013
10004013 116691 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 452 7 1 7 4.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(c2ccccc2)c2nnn[nH]2)cc1 10.1021/jm00078a014
CHEMBL337217 116691 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 452 7 1 7 4.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(c2ccccc2)c2nnn[nH]2)cc1 10.1021/jm00078a014
14956744 206161 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86255 206161 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1726745 23928 None 11 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 390 8 1 6 3.4 O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1ccccc1Cl nan
CHEMBL1337184 23928 None 11 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 390 8 1 6 3.4 O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1ccccc1Cl nan
5731702 186650 None 10 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 3 1 3 4.1 COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1 nan
CHEMBL488140 186650 None 10 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 3 1 3 4.1 COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1 nan
2476054 47895 None 3 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 347 3 3 4 3.9 FC(F)(F)c1cnc(NN=C(S)Nc2cccnc2)c(Cl)c1 nan
CHEMBL1549272 47895 None 3 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 347 3 3 4 3.9 FC(F)(F)c1cnc(NN=C(S)Nc2cccnc2)c(Cl)c1 nan
2458676 31408 None 4 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 373 6 1 6 2.4 CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2cc3ccccc3o2)c1 nan
CHEMBL1402558 31408 None 4 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 373 6 1 6 2.4 CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2cc3ccccc3o2)c1 nan
2221657 34513 None 11 Human Functional pIC50 = 4.8 4.8 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 353 2 0 5 3.6 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccc(Cl)cn1 nan
CHEMBL1428950 34513 None 11 Human Functional pIC50 = 4.8 4.8 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 353 2 0 5 3.6 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccc(Cl)cn1 nan
44342039 10291 None 0 Human Functional pIC50 = 6.8 6.8 -21 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 418 7 1 3 5.7 CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL116170 10291 None 0 Human Functional pIC50 = 6.8 6.8 -21 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 418 7 1 3 5.7 CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
2426360 46885 None 6 Human Functional pIC50 = 4.8 4.8 -8 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 382 3 3 3 4.6 Fc1ccc(N=C(S)NNc2ncc(C(F)(F)F)cc2Cl)c(F)c1 nan
CHEMBL1540808 46885 None 6 Human Functional pIC50 = 4.8 4.8 -8 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 382 3 3 3 4.6 Fc1ccc(N=C(S)NNc2ncc(C(F)(F)F)cc2Cl)c(F)c1 nan
9653239 107646 None 5 Human Functional pIC50 = 5.8 5.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 291 3 2 4 2.7 O=C(N/N=C/c1cccc2cccnc12)c1ccccc1O nan
CHEMBL3190198 107646 None 5 Human Functional pIC50 = 5.8 5.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 291 3 2 4 2.7 O=C(N/N=C/c1cccc2cccnc12)c1ccccc1O nan
5730138 34792 None 11 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 307 4 1 4 4.1 COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC nan
CHEMBL1431014 34792 None 11 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 307 4 1 4 4.1 COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC nan
12005285 53062 None 6 Human Functional pIC50 = 5.8 5.8 3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 402 8 1 9 4.0 CC(=O)OCCCNc1cc(Sc2ccc(C)cc2)c2nonc2c1[N+](=O)[O-] nan
CHEMBL1597454 53062 None 6 Human Functional pIC50 = 5.8 5.8 3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 402 8 1 9 4.0 CC(=O)OCCCNc1cc(Sc2ccc(C)cc2)c2nonc2c1[N+](=O)[O-] nan
1767917 31234 None 10 Human Functional pIC50 = 4.8 4.8 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 375 5 3 4 2.2 Cc1nn(CCC(=O)NNC(S)=NCC(C)C)c(C)c1Br nan
CHEMBL1401122 31234 None 10 Human Functional pIC50 = 4.8 4.8 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 375 5 3 4 2.2 Cc1nn(CCC(=O)NNC(S)=NCC(C)C)c(C)c1Br nan
14956806 106928 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 497 10 1 8 5.0 CCCCc1nn(CSc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314810 106928 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 497 10 1 8 5.0 CCCCc1nn(CSc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956768 106969 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 499 8 1 7 5.2 CC(C)CCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315077 106969 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 499 8 1 7 5.2 CC(C)CCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956745 206267 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86906 206267 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14951062 206389 None 0 Rabbit Functional pIC50 = 7.8 7.8 -1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 429 9 1 7 3.7 CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87669 206389 None 0 Rabbit Functional pIC50 = 7.8 7.8 -1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 429 9 1 7 3.7 CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971694 14690 None 0 Rabbit Functional pIC50 = 6.8 6.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 416 8 2 6 4.0 CCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120605 14690 None 0 Rabbit Functional pIC50 = 6.8 6.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 416 8 2 6 4.0 CCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
44355660 21555 None 0 Rabbit Functional pIC50 = 6.8 6.8 89 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 483 7 1 7 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 10.1021/jm00078a013
CHEMBL131676 21555 None 0 Rabbit Functional pIC50 = 6.8 6.8 89 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 483 7 1 7 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 10.1021/jm00078a013
10410730 24616 None 0 Rabbit Functional pIC50 = 5.8 5.8 6 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 10.1021/jm00078a013
CHEMBL134307 24616 None 0 Rabbit Functional pIC50 = 5.8 5.8 6 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 10.1021/jm00078a013
2898434 53866 None 12 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 6 0 7 1.9 O=C(CN1C(=O)C2CC=CCC2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1604741 53866 None 12 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 6 0 7 1.9 O=C(CN1C(=O)C2CC=CCC2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
3532334 42350 None 9 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 2 1 4 3.2 O=c1c2cc(Cl)ccc2[nH]c(=S)n1Cc1ccccn1 nan
CHEMBL1498428 42350 None 9 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 2 1 4 3.2 O=c1c2cc(Cl)ccc2[nH]c(=S)n1Cc1ccccn1 nan
2640418 22146 None 7 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 377 6 0 6 2.5 O=C(COC(=O)c1ccco1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
CHEMBL1322344 22146 None 7 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 377 6 0 6 2.5 O=C(COC(=O)c1ccco1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
5687785 108402 None 2 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 346 5 1 5 3.2 O=C(N/N=C(\c1ccccc1)c1ccccn1)c1cccc([N+](=O)[O-])c1 nan
CHEMBL3198576 108402 None 2 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 346 5 1 5 3.2 O=C(N/N=C(\c1ccccc1)c1ccccn1)c1cccc([N+](=O)[O-])c1 nan
5735740 41648 None 10 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 321 5 1 4 4.5 CCOc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC nan
CHEMBL1491932 41648 None 10 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 321 5 1 4 4.5 CCOc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC nan
2320855 36550 None 6 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 333 4 4 7 0.6 O=C1OCC(CO)(CO)N=C1NNc1ccc(Cl)c(Cl)c1 nan
CHEMBL1448161 36550 None 6 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 333 4 4 7 0.6 O=C1OCC(CO)(CO)N=C1NNc1ccc(Cl)c(Cl)c1 nan
5091521 25293 None 7 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 402 2 2 9 2.9 CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(NN)ncnc4c23)CS1 nan
CHEMBL1348954 25293 None 7 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 402 2 2 9 2.9 CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(NN)ncnc4c23)CS1 nan
2121806 42063 None 5 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 266 4 1 6 2.3 CCSc1nnc(NC(=O)c2ccccn2)s1 nan
CHEMBL1495849 42063 None 5 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 266 4 1 6 2.3 CCSc1nnc(NC(=O)c2ccccn2)s1 nan
2733001 29295 None 4 Human Functional pIC50 = 4.8 4.8 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 5 1 4 3.7 Cc1ccc(C(C[N+](=O)[O-])Sc2ccc(N)cc2)cc1 nan
CHEMBL1382939 29295 None 4 Human Functional pIC50 = 4.8 4.8 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 5 1 4 3.7 Cc1ccc(C(C[N+](=O)[O-])Sc2ccc(N)cc2)cc1 nan
25162518 39850 None 5 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 417 8 0 6 2.7 O=C(COc1ccccc1)OCC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
CHEMBL1477291 39850 None 5 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 417 8 0 6 2.7 O=C(COc1ccccc1)OCC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
14956784 106555 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 447 9 1 9 2.5 CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314179 106555 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 447 9 1 9 2.5 CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956764 206075 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 541 8 1 7 5.0 CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85541 206075 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 541 8 1 7 5.0 CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44355628 24904 None 0 Rabbit Functional pIC50 = 6.8 6.8 5 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 508 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O 10.1021/jm00078a013
CHEMBL134567 24904 None 0 Rabbit Functional pIC50 = 6.8 6.8 5 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 508 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O 10.1021/jm00078a013
10095493 26046 None 0 Rabbit Functional pIC50 = 6.8 6.8 93 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 454 6 0 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 10.1021/jm00078a013
CHEMBL135521 26046 None 0 Rabbit Functional pIC50 = 6.8 6.8 93 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 454 6 0 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 10.1021/jm00078a013
1336623 38285 None 20 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 350 5 0 6 3.5 Cc1cc(C(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)c2ccccc2n1 nan
CHEMBL1462517 38285 None 20 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 350 5 0 6 3.5 Cc1cc(C(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)c2ccccc2n1 nan
2165745 34678 None 9 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 425 8 1 8 0.7 O=C(CN1C(=O)c2ccccc2C1=O)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1430172 34678 None 9 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 425 8 1 8 0.7 O=C(CN1C(=O)c2ccccc2C1=O)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
659805 21964 None 6 Human Functional pIC50 = 4.8 4.8 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 302 1 2 4 3.7 ON1C(c2ccc(Cl)cc2Cl)N(O)[C@@H]2CCCC[C@@H]21 nan
CHEMBL1320678 21964 None 6 Human Functional pIC50 = 4.8 4.8 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 302 1 2 4 3.7 ON1C(c2ccc(Cl)cc2Cl)N(O)[C@@H]2CCCC[C@@H]21 nan
135415440 199048 None 11 Human Functional pIC50 = 5.8 5.8 -10 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 295 3 2 6 3.0 Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 nan
CHEMBL586135 199048 None 11 Human Functional pIC50 = 5.8 5.8 -10 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 295 3 2 6 3.0 Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 nan
579121 49130 None 12 Human Functional pIC50 = 4.8 4.8 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 377 4 1 4 4.7 COc1ccc(NC2(c3ccc(Cl)cc3)C(=O)c3ccccc3C2=O)cc1 nan
CHEMBL1561907 49130 None 12 Human Functional pIC50 = 4.8 4.8 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 377 4 1 4 4.7 COc1ccc(NC2(c3ccc(Cl)cc3)C(=O)c3ccccc3C2=O)cc1 nan
24983202 27812 None 5 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 444 7 1 6 2.9 CC(=O)Nc1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 nan
CHEMBL1371002 27812 None 5 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 444 7 1 6 2.9 CC(=O)Nc1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 nan
14971686 15247 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 507 10 1 8 5.2 CCCCc1nn(-c2ccccn2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL121125 15247 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 507 10 1 8 5.2 CCCCc1nn(-c2ccccn2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10414429 115995 None 0 Rabbit Functional pIC50 = 7.8 7.8 363 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 522 5 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O 10.1021/jm00078a013
CHEMBL335535 115995 None 0 Rabbit Functional pIC50 = 7.8 7.8 363 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 522 5 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O 10.1021/jm00078a013
10322211 169470 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 464 6 1 7 4.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 10.1021/jm00078a013
CHEMBL442963 169470 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 464 6 1 7 4.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 10.1021/jm00078a013
14956741 107052 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315615 107052 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44292094 101442 None 0 Bovine Functional pIC50 = 6.8 6.8 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 585 9 1 9 6.4 CCCCc1nc2ccc(C3CC(c4cc(C)co4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL297583 101442 None 0 Bovine Functional pIC50 = 6.8 6.8 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 585 9 1 9 6.4 CCCCc1nc2ccc(C3CC(c4cc(C)co4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
23205 116918 None 40 Human Functional pIC50 = 4.7 4.7 -7 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 262 0 1 4 1.2 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](O)[C@H]12 nan
CHEMBL338474 116918 None 40 Human Functional pIC50 = 4.7 4.7 -7 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 262 0 1 4 1.2 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](O)[C@H]12 nan
24981067 45201 None 5 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 480 8 1 7 1.8 CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 nan
CHEMBL1525764 45201 None 5 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 480 8 1 7 1.8 CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 nan
768473 49969 None 6 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 267 6 0 2 3.9 CCN(CC)CC(=O)c1ccc(-c2ccccc2)cc1 nan
CHEMBL1568922 49969 None 6 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 267 6 0 2 3.9 CCN(CC)CC(=O)c1ccc(-c2ccccc2)cc1 nan
4799115 24528 None 8 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 332 3 2 4 4.1 O=C(Nc1nc(-c2ccccn2)cs1)Nc1ccc(F)cc1F nan
CHEMBL1342423 24528 None 8 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 332 3 2 4 4.1 O=C(Nc1nc(-c2ccccn2)cs1)Nc1ccc(F)cc1F nan
11957260 33011 None 6 Human Functional pIC50 = 5.7 5.7 5 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 389 6 2 10 3.3 O=[N+]([O-])c1c(NCCO)cc(Sc2nc3ccccc3s2)c2nonc12 nan
CHEMBL1416184 33011 None 6 Human Functional pIC50 = 5.7 5.7 5 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 389 6 2 10 3.3 O=[N+]([O-])c1c(NCCO)cc(Sc2nc3ccccc3s2)c2nonc12 nan
1610 2345 None 95 Rat Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
3941 2345 None 95 Rat Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
3961 2345 None 95 Rat Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
590 2345 None 95 Rat Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
CHEMBL191 2345 None 95 Rat Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
DB00678 2345 None 95 Rat Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
1610 2345 None 95 Rabbit Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
3941 2345 None 95 Rabbit Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
3961 2345 None 95 Rabbit Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
590 2345 None 95 Rabbit Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
CHEMBL191 2345 None 95 Rabbit Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
DB00678 2345 None 95 Rabbit Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
10069786 169099 None 0 Human Functional pIC50 = 6.7 6.7 -19 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 404 7 1 3 5.3 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL439968 169099 None 0 Human Functional pIC50 = 6.7 6.7 -19 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 404 7 1 3 5.3 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
10393397 22797 None 0 Rabbit Functional pIC50 = 5.7 5.7 6 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 578 8 1 5 7.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
CHEMBL132807 22797 None 0 Rabbit Functional pIC50 = 5.7 5.7 6 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 578 8 1 5 7.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
568849 31719 None 10 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 313 7 0 5 3.0 O=C(CCc1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1405657 31719 None 10 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 313 7 0 5 3.0 O=C(CCc1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
5720743 108248 None 10 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 257 3 1 3 2.4 C/C(=N\NC(=O)c1ccc(F)cc1)c1ccccn1 nan
CHEMBL3197070 108248 None 10 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 257 3 1 3 2.4 C/C(=N\NC(=O)c1ccc(F)cc1)c1ccccn1 nan
761850 38792 None 10 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 5 0 6 2.3 Cc1ccc(C(=O)COC(=O)c2ccncc2)cc1[N+](=O)[O-] nan
CHEMBL1466556 38792 None 10 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 5 0 6 2.3 Cc1ccc(C(=O)COC(=O)c2ccncc2)cc1[N+](=O)[O-] nan
142534050 166964 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 545 11 1 7 5.2 CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4287379 166964 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 545 11 1 7 5.2 CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14971712 99601 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 402 8 3 5 3.9 CCCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL283975 99601 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 402 8 3 5 3.9 CCCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956756 206369 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 529 8 1 7 5.0 CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87513 206369 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 529 8 1 7 5.0 CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
20081627 92168 None 0 Rabbit Functional pIC50 = 8.7 8.7 -1 2
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 502 6 2 7 4.7 CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
CHEMBL24224 92168 None 0 Rabbit Functional pIC50 = 8.7 8.7 -1 2
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 502 6 2 7 4.7 CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
44459871 92528 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 573 8 1 8 4.2 CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)CCC1=O 10.1016/S0960-894X(01)80348-6
CHEMBL2079791 92528 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 573 8 1 8 4.2 CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)CCC1=O 10.1016/S0960-894X(01)80348-6
CHEMBL24319 92528 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 573 8 1 8 4.2 CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)CCC1=O 10.1016/S0960-894X(01)80348-6
44459655 93223 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 575 9 1 8 4.3 CCCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
CHEMBL2079788 93223 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 575 9 1 8 4.3 CCCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
CHEMBL24478 93223 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 575 9 1 8 4.3 CCCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
44459835 168037 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 587 8 1 8 4.5 CC1CC(=O)N(CC(=O)N(C)C)N=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
CHEMBL2079790 168037 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 587 8 1 8 4.5 CC1CC(=O)N(CC(=O)N(C)C)N=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
CHEMBL432271 168037 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 587 8 1 8 4.5 CC1CC(=O)N(CC(=O)N(C)C)N=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
44459654 168108 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 601 8 1 8 4.9 CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)(C)CC1=O 10.1016/S0960-894X(01)80348-6
CHEMBL2079787 168108 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 601 8 1 8 4.9 CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)(C)CC1=O 10.1016/S0960-894X(01)80348-6
CHEMBL432847 168108 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 601 8 1 8 4.9 CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)(C)CC1=O 10.1016/S0960-894X(01)80348-6
22942227 70876 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 569 10 1 9 3.5 CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951130 70876 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 569 10 1 9 3.5 CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
22942226 70877 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 554 10 2 8 2.8 CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951131 70877 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 554 10 2 8 2.8 CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
142534121 166719 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 559 11 1 7 5.4 CCCCc1nc(C)c(CC(=S)N(C)CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4282931 166719 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 559 11 1 7 5.4 CCCCc1nc(C)c(CC(=S)N(C)CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14971638 114873 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 478 9 2 6 5.5 CCCCc1nc(-c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL334192 114873 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 478 9 2 6 5.5 CCCCc1nc(-c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
9845644 206431 None 0 Rabbit Functional pIC50 = 8.7 8.7 5 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 9 1 7 4.3 CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87964 206431 None 0 Rabbit Functional pIC50 = 8.7 8.7 5 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 9 1 7 4.3 CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956779 68661 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 445 8 1 7 4.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL19202 68661 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 445 8 1 7 4.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
142533975 167046 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 571 10 1 7 5.7 CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4288964 167046 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 571 10 1 7 5.7 CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
155517399 170179 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 557 10 1 6 6.8 CCCCC1=NC(C(C)C)=C(CC(=S)N2CCCC2)CN1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.12.043
CHEMBL4444760 170179 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 557 10 1 6 6.8 CCCCC1=NC(C(C)C)=C(CC(=S)N2CCCC2)CN1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.12.043
14971699 112781 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL330571 112781 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
44213343 70872 None 29 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 485 9 1 7 3.4 CCCCc1nc(C)c(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951126 70872 None 29 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 485 9 1 7 3.4 CCCCc1nc(C)c(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
9935106 65280 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL18287 65280 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44213346 70878 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 525 9 1 7 4.3 CCCCc1nc(C)c(CC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951132 70878 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 525 9 1 7 4.3 CCCCc1nc(C)c(CC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971709 15345 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 553 11 2 9 5.3 CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL121416 15345 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 553 11 2 9 5.3 CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
57401930 70866 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 500 11 1 8 4.3 CCCCc1nc(C)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951120 70866 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 500 11 1 8 4.3 CCCCc1nc(C)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
44213342 70869 None 15 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 458 9 2 7 3.4 CCCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951123 70869 None 15 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 458 9 2 7 3.4 CCCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971713 167981 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 430 9 2 6 4.4 CCCCc1nn(CC)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL431887 167981 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 430 9 2 6 4.4 CCCCc1nn(CC)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
57393227 70880 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 543 9 1 8 3.9 CCCCc1nc(C)c(CC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951134 70880 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 543 9 1 8 3.9 CCCCc1nc(C)c(CC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
108185 1612 None 78 Rabbit Functional pIC50 = 8.6 8.6 -3 5
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00075a014
586 1612 None 78 Rabbit Functional pIC50 = 8.6 8.6 -3 5
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00075a014
CHEMBL907 1612 None 78 Rabbit Functional pIC50 = 8.6 8.6 -3 5
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00075a014
14971697 111539 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 478 9 2 6 5.4 CCCCc1nn(-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL327982 111539 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 478 9 2 6 5.4 CCCCc1nn(-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10298977 206321 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 471 9 1 7 4.9 CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87239 206321 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 471 9 1 7 4.9 CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
131654 206401 None 12 Rabbit Functional pIC50 = 8.5 8.5 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87778 206401 None 12 Rabbit Functional pIC50 = 8.5 8.5 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971683 14860 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 536 11 1 8 5.8 CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120750 14860 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 536 11 1 8 5.8 CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971692 112951 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 560 9 1 7 6.7 CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL331078 112951 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 560 9 1 7 6.7 CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10026868 23857 None 0 Rabbit Functional pIC50 = 7.7 7.7 331 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 452 5 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 10.1021/jm00078a013
CHEMBL133653 23857 None 0 Rabbit Functional pIC50 = 7.7 7.7 331 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 452 5 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 10.1021/jm00078a013
14956766 106977 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 471 7 1 7 4.5 CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315128 106977 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 471 7 1 7 4.5 CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
2540 4399 None 111 Rabbit Functional pIC50 = 6.7 6.7 -28 28
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1014 4399 None 111 Rabbit Functional pIC50 = 6.7 6.7 -28 28
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
10409549 115976 None 0 Rabbit Functional pIC50 = 6.7 6.7 104 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 414 7 2 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL335514 115976 None 0 Rabbit Functional pIC50 = 6.7 6.7 104 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 414 7 2 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10345459 116768 None 0 Rabbit Functional pIC50 = 6.7 6.7 43 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 490 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F 10.1021/jm00078a014
CHEMBL337663 116768 None 0 Rabbit Functional pIC50 = 6.7 6.7 43 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 490 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F 10.1021/jm00078a014
25163176 44090 None 5 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 431 8 0 6 2.8 COc1ccc(CC(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1 nan
CHEMBL1514866 44090 None 5 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 431 8 0 6 2.8 COc1ccc(CC(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1 nan
3116640 20405 None 12 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 542 6 0 7 2.1 O=C(CN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1306605 20405 None 12 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 542 6 0 7 2.1 O=C(CN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
1653162 49995 None 11 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 335 3 3 5 1.7 COc1ccccc1C(=O)NNC(=S)NC(=O)c1cccs1 nan
CHEMBL1569107 49995 None 11 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 335 3 3 5 1.7 COc1ccccc1C(=O)NNC(=S)NC(=O)c1cccs1 nan
11957180 22742 None 6 Human Functional pIC50 = 5.7 5.7 6 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 403 7 2 10 3.7 O=[N+]([O-])c1c(NCCCO)cc(Sc2nc3ccccc3s2)c2nonc12 nan
CHEMBL1327721 22742 None 6 Human Functional pIC50 = 5.7 5.7 6 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 403 7 2 10 3.7 O=[N+]([O-])c1c(NCCCO)cc(Sc2nc3ccccc3s2)c2nonc12 nan
11957209 43032 None 6 Human Functional pIC50 = 5.7 5.7 6 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 445 8 1 11 4.3 CC(=O)OCCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] nan
CHEMBL1504429 43032 None 6 Human Functional pIC50 = 5.7 5.7 6 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 445 8 1 11 4.3 CC(=O)OCCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] nan
9550611 49762 None 6 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 403 6 1 10 3.3 CN(CCO)c1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] nan
CHEMBL1567159 49762 None 6 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 403 6 1 10 3.3 CN(CCO)c1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] nan
780302 31881 None 7 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 340 3 2 4 3.9 NNc1nc(-c2ccccc2)cc(-c2ccc(Br)cc2)n1 nan
CHEMBL1407100 31881 None 7 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 340 3 2 4 3.9 NNc1nc(-c2ccccc2)cc(-c2ccc(Br)cc2)n1 nan
14971681 111518 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL327862 111518 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956771 206351 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 482 8 1 9 3.8 CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87392 206351 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 482 8 1 9 3.8 CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956750 206083 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 469 8 1 7 4.4 CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85596 206083 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 469 8 1 7 4.4 CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
2412928 21715 None 7 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 500 7 1 11 1.5 Cn1c(N)c(C(=O)COC(=O)c2ccccc2C(=O)c2ccc(Cl)c([N+](=O)[O-])c2)c(=O)n(C)c1=O nan
CHEMBL1318653 21715 None 7 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 500 7 1 11 1.5 Cn1c(N)c(C(=O)COC(=O)c2ccccc2C(=O)c2ccc(Cl)c([N+](=O)[O-])c2)c(=O)n(C)c1=O nan
6418891 22814 None 13 Human Functional pIC50 = 4.7 4.7 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 401 3 0 4 5.7 FC(F)(F)c1cccc(Sc2nc(-c3ccccc3)nnc2C(F)(F)F)c1 nan
CHEMBL1328168 22814 None 13 Human Functional pIC50 = 4.7 4.7 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 401 3 0 4 5.7 FC(F)(F)c1cccc(Sc2nc(-c3ccccc3)nnc2C(F)(F)F)c1 nan
2815589 41671 None 5 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 272 5 2 3 2.2 NC(=O)c1ccccc1NCC(=O)c1ccc(F)cc1 nan
CHEMBL1492089 41671 None 5 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 272 5 2 3 2.2 NC(=O)c1ccccc1NCC(=O)c1ccc(F)cc1 nan
16436605 38458 None 9 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 486 6 1 7 2.6 CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCCC(C)C3)cc2)n1 nan
CHEMBL1464024 38458 None 9 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 486 6 1 7 2.6 CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCCC(C)C3)cc2)n1 nan
11159916 123849 None 6 Rabbit Functional pIC50 = 4.7 4.7 - 1
Vasorelaxing potency was determinedVasorelaxing potency was determined
ChEMBL 197 4 1 4 1.1 O=C(O)c1cccc(CO[N+](=O)[O-])c1 10.1021/jm049681p
CHEMBL362550 123849 None 6 Rabbit Functional pIC50 = 4.7 4.7 - 1
Vasorelaxing potency was determinedVasorelaxing potency was determined
ChEMBL 197 4 1 4 1.1 O=C(O)c1cccc(CO[N+](=O)[O-])c1 10.1021/jm049681p
442142 185468 None 16 Human Functional pIC50 = 4.7 4.7 -4 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 304 1 0 5 1.8 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(C)=O)[C@H]12 nan
CHEMBL486196 185468 None 16 Human Functional pIC50 = 4.7 4.7 -4 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 304 1 0 5 1.8 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(C)=O)[C@H]12 nan
53317942 57596 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cellsAntagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cells
ChEMBL 444 7 1 7 3.3 CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O 10.1016/j.bmc.2010.10.043
CHEMBL1667999 57596 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cellsAntagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cells
ChEMBL 444 7 1 7 3.3 CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O 10.1016/j.bmc.2010.10.043
14971695 14869 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 10 1 7 5.5 CCCc1nn(Cc2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120762 14869 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 10 1 7 5.5 CCCc1nn(Cc2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
44292181 101162 None 0 Bovine Functional pIC50 = 7.7 7.7 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.0 CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL295529 101162 None 0 Bovine Functional pIC50 = 7.7 7.7 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.0 CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
9982177 26497 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 9 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC(C)C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL136028 26497 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 9 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC(C)C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10275744 206116 None 0 Rabbit Functional pIC50 = 7.7 7.7 2 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 451 8 1 7 4.3 CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85876 206116 None 0 Rabbit Functional pIC50 = 7.7 7.7 2 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 451 8 1 7 4.3 CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
2939837 37270 None 7 Human Functional pIC50 = 4.7 4.7 -4 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 363 2 3 4 3.9 CC(C)(C)c1cc(Cl)c(O)c(NC(=S)NC(=O)c2cccnc2)c1 nan
CHEMBL1453857 37270 None 7 Human Functional pIC50 = 4.7 4.7 -4 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 363 2 3 4 3.9 CC(C)(C)c1cc(Cl)c(O)c(NC(=S)NC(=O)c2cccnc2)c1 nan
800048 24483 None 28 Human Functional pIC50 = 5.7 5.7 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 252 2 0 4 2.6 CCn1c(=O)c([N+](=O)[O-])c(Cl)c2ccccc21 nan
CHEMBL1342053 24483 None 28 Human Functional pIC50 = 5.7 5.7 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 252 2 0 4 2.6 CCn1c(=O)c([N+](=O)[O-])c(Cl)c2ccccc21 nan
972880 194362 None 10 Human Functional pIC50 = 5.7 5.7 -6 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 268 3 1 5 3.7 Cc1cccnc1Nc1nc(-c2ccccn2)cs1 nan
CHEMBL528694 194362 None 10 Human Functional pIC50 = 5.7 5.7 -6 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 268 3 1 5 3.7 Cc1cccnc1Nc1nc(-c2ccccn2)cs1 nan
9660957 72754 None 12 Human Functional pIC50 = 5.7 5.7 -1 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 330 4 0 5 2.3 CCn1c(Cl)c(C=O)s/c1=N\S(=O)(=O)c1ccccc1 nan
CHEMBL1999049 72754 None 12 Human Functional pIC50 = 5.7 5.7 -1 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 330 4 0 5 2.3 CCn1c(Cl)c(C=O)s/c1=N\S(=O)(=O)c1ccccc1 nan
1472225 24742 None 11 Human Functional pIC50 = 5.7 5.7 -5 7
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
CHEMBL1344225 24742 None 11 Human Functional pIC50 = 5.7 5.7 -5 7
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
3734285 46612 None 17 Human Functional pIC50 = 4.7 4.7 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 399 7 1 4 4.8 CN(C)CCCNC(=O)c1ccc(-c2nc(-c3ccc(Cl)cc3)cs2)cc1 nan
CHEMBL1538399 46612 None 17 Human Functional pIC50 = 4.7 4.7 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 399 7 1 4 4.8 CN(C)CCCNC(=O)c1ccc(-c2nc(-c3ccc(Cl)cc3)cs2)cc1 nan
5335941 107907 None 8 Human Functional pIC50 = 4.7 4.7 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 279 2 2 2 3.4 CC1CC2=C(CC1/C=N/NC(N)=S)C(C)(C)CCC2 nan
CHEMBL3193181 107907 None 8 Human Functional pIC50 = 4.7 4.7 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 279 2 2 2 3.4 CC1CC2=C(CC1/C=N/NC(N)=S)C(C)(C)CCC2 nan
9590741 107846 None 5 Human Functional pIC50 = 5.6 5.6 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 3 1 3 2.9 C/C(=N\NC(=O)c1ccc(Cl)cc1)c1ccccn1 nan
CHEMBL3192432 107846 None 5 Human Functional pIC50 = 5.6 5.6 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 3 1 3 2.9 C/C(=N\NC(=O)c1ccc(Cl)cc1)c1ccccn1 nan
2539399 39887 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 392 4 2 5 2.4 Cc1cc(C)nc(NNS(=O)(=O)c2c(F)cc(F)cc2Br)n1 nan
CHEMBL1477553 39887 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 392 4 2 5 2.4 Cc1cc(C)nc(NNS(=O)(=O)c2c(F)cc(F)cc2Br)n1 nan
11159916 123849 None 6 Rabbit Functional pIC50 = 4.6 4.6 - 1
Vasorelaxing potency in the presence of eserin was determinedVasorelaxing potency in the presence of eserin was determined
ChEMBL 197 4 1 4 1.1 O=C(O)c1cccc(CO[N+](=O)[O-])c1 10.1021/jm049681p
CHEMBL362550 123849 None 6 Rabbit Functional pIC50 = 4.6 4.6 - 1
Vasorelaxing potency in the presence of eserin was determinedVasorelaxing potency in the presence of eserin was determined
ChEMBL 197 4 1 4 1.1 O=C(O)c1cccc(CO[N+](=O)[O-])c1 10.1021/jm049681p
2283939 44412 None 10 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 404 8 1 6 3.7 Cc1ccc(C(=O)COC(=O)CCC(=O)Nc2ccccc2Cl)cc1[N+](=O)[O-] nan
CHEMBL1518619 44412 None 10 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 404 8 1 6 3.7 Cc1ccc(C(=O)COC(=O)CCC(=O)Nc2ccccc2Cl)cc1[N+](=O)[O-] nan
14971685 156517 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 582 11 1 7 7.5 CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL406791 156517 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 582 11 1 7 7.5 CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10113613 106757 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 7 1 7 4.0 CCCCc1nn(C(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314436 106757 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 7 1 7 4.0 CCCCc1nn(C(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956797 206417 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87885 206417 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10048776 115220 None 0 Rabbit Functional pIC50 = 6.6 6.6 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 438 6 1 5 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)O)c1 10.1021/jm00078a013
CHEMBL334622 115220 None 0 Rabbit Functional pIC50 = 6.6 6.6 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 438 6 1 5 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)O)c1 10.1021/jm00078a013
1096078 49618 None 5 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 364 4 1 4 4.2 COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)c2ncccc12 nan
CHEMBL1566084 49618 None 5 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 364 4 1 4 4.2 COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)c2ncccc12 nan
2645512 32458 None 6 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 455 6 0 6 3.3 O=C(COC(=O)c1ccc(Br)o1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
CHEMBL1411597 32458 None 6 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 455 6 0 6 3.3 O=C(COC(=O)c1ccc(Br)o1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
2171031 39171 None 10 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 356 8 1 6 1.7 O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1469682 39171 None 10 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 356 8 1 6 1.7 O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
889369 54484 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 315 3 3 4 3.0 CC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 nan
CHEMBL1609718 54484 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 315 3 3 4 3.0 CC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 nan
2905495 20018 None 14 Human Functional pIC50 = 5.6 5.6 1 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 400 4 1 9 3.3 Cc1c(Nc2cc(Cl)c3nonc3c2[N+](=O)[O-])c(=O)n(-c2ccccc2)n1C nan
CHEMBL1303426 20018 None 14 Human Functional pIC50 = 5.6 5.6 1 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 400 4 1 9 3.3 Cc1c(Nc2cc(Cl)c3nonc3c2[N+](=O)[O-])c(=O)n(-c2ccccc2)n1C nan
3239204 54015 None 11 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 4 1 7 4.0 COc1cccc2sc(Nc3nc(C)c(C(C)=O)s3)nc12 nan
CHEMBL1605977 54015 None 11 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 4 1 7 4.0 COc1cccc2sc(Nc3nc(C)c(C(C)=O)s3)nc12 nan
2848041 22080 None 6 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 298 3 1 3 3.3 Cc1ccc2cccc(NS(=O)(=O)c3ccccc3)c2n1 nan
CHEMBL1321754 22080 None 6 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 298 3 1 3 3.3 Cc1ccc2cccc(NS(=O)(=O)c3ccccc3)c2n1 nan
1472220 41893 None 11 Human Functional pIC50 = 5.6 5.6 3 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 418 6 1 4 4.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(Cl)cc2)cn1 nan
CHEMBL1494120 41893 None 11 Human Functional pIC50 = 5.6 5.6 3 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 418 6 1 4 4.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(Cl)cc2)cn1 nan
135636104 44073 None 9 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 217 3 1 5 2.7 O=[N+]([O-])c1ccc(N=Nc2ncc[nH]2)cc1 nan
CHEMBL1514691 44073 None 9 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 217 3 1 5 2.7 O=[N+]([O-])c1ccc(N=Nc2ncc[nH]2)cc1 nan
936147 52668 None 8 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 306 6 0 4 4.3 CCCN(CCC)c1nc(-c2ccccn2)nc2ccccc12 nan
CHEMBL1593888 52668 None 8 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 306 6 0 4 4.3 CCCN(CCC)c1nc(-c2ccccn2)nc2ccccc12 nan
8480343 43909 None 6 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 330 4 2 5 2.2 Cc1cc(C)nc(NNS(=O)(=O)c2ccc(F)c(Cl)c2)n1 nan
CHEMBL1512236 43909 None 6 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 330 4 2 5 2.2 Cc1cc(C)nc(NNS(=O)(=O)c2ccc(F)c(Cl)c2)n1 nan
2632794 22759 None 5 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 312 5 0 4 3.5 O=C(Cc1ccc(F)cc1)OCC(=O)c1cc2ccccc2o1 nan
CHEMBL1327815 22759 None 5 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 312 5 0 4 3.5 O=C(Cc1ccc(F)cc1)OCC(=O)c1cc2ccccc2o1 nan
14956786 106963 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 433 9 2 8 2.8 CCCCc1nn(C(C)CO)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315012 106963 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 433 9 2 8 2.8 CCCCc1nn(C(C)CO)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10250898 118486 None 0 Rabbit Functional pIC50 = 6.6 6.6 37 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 408 4 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 10.1021/jm00078a013
CHEMBL341407 118486 None 0 Rabbit Functional pIC50 = 6.6 6.6 37 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 408 4 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 10.1021/jm00078a013
6908540 107746 None 19 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 305 5 1 5 1.9 O=[N+]([O-])c1cccc(/C=N/NS(=O)(=O)c2ccccc2)c1 nan
CHEMBL3191392 107746 None 19 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 305 5 1 5 1.9 O=[N+]([O-])c1cccc(/C=N/NS(=O)(=O)c2ccccc2)c1 nan
2739277 29689 None 5 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 364 4 2 5 4.3 O=C(NNc1ccc(-c2csnn2)cc1)c1cc(Cl)cc(Cl)c1 nan
CHEMBL1386393 29689 None 5 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 364 4 2 5 4.3 O=C(NNc1ccc(-c2csnn2)cc1)c1cc(Cl)cc(Cl)c1 nan
135478724 35129 None 33 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 240 1 1 2 2.9 O=C1Nc2ccccc2C1=Nc1ccc(F)cc1 nan
CHEMBL1434292 35129 None 33 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 240 1 1 2 2.9 O=C1Nc2ccccc2C1=Nc1ccc(F)cc1 nan
3118020 47484 None 13 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 400 6 0 7 1.7 CC(C(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)N1C(=O)C2C3CCC(C3)C2C1=O nan
CHEMBL1545561 47484 None 13 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 400 6 0 7 1.7 CC(C(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)N1C(=O)C2C3CCC(C3)C2C1=O nan
164613537 185124 None 0 Human Functional pIC50 = 7.6 7.6 21 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 464 8 1 5 5.4 CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL4856425 185124 None 0 Human Functional pIC50 = 7.6 7.6 21 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 464 8 1 5 5.4 CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
10025873 115532 None 0 Rabbit Functional pIC50 = 6.6 6.6 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 433 4 0 6 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C#N)c1 10.1021/jm00078a013
CHEMBL335323 115532 None 0 Rabbit Functional pIC50 = 6.6 6.6 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 433 4 0 6 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C#N)c1 10.1021/jm00078a013
14956765 206420 None 0 Rabbit Functional pIC50 = 6.6 6.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 469 6 1 7 4.5 O=c1n(-c2ccccc2Cl)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87890 206420 None 0 Rabbit Functional pIC50 = 6.6 6.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 469 6 1 7 4.5 O=c1n(-c2ccccc2Cl)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
773605 45176 None 22 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 253 2 2 3 3.3 Fc1ccc(NC(S)=Nc2nccs2)cc1 nan
CHEMBL1525546 45176 None 22 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 253 2 2 3 3.3 Fc1ccc(NC(S)=Nc2nccs2)cc1 nan
3754656 47930 None 8 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 362 8 1 6 2.6 O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)NC1CCCCC1 nan
CHEMBL1549587 47930 None 8 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 362 8 1 6 2.6 O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)NC1CCCCC1 nan
933895 22716 None 32 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 166 2 2 5 1.0 CC(C)c1nc(C#N)c(NN)o1 nan
CHEMBL1327546 22716 None 32 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 166 2 2 5 1.0 CC(C)c1nc(C#N)c(NN)o1 nan
42600949 54384 None 0 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 385 4 1 5 3.9 CCC1Nc2ncnc(N3CCCCC3)c2N(Cc2ccc(Cl)cc2)C1=O nan
CHEMBL1608922 54384 None 0 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 385 4 1 5 3.9 CCC1Nc2ncnc(N3CCCCC3)c2N(Cc2ccc(Cl)cc2)C1=O nan
CHEMBL2131333 54384 None 0 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 385 4 1 5 3.9 CCC1Nc2ncnc(N3CCCCC3)c2N(Cc2ccc(Cl)cc2)C1=O nan
2811327 34322 None 5 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 4 2 2 4.0 CCc1ccc(C(=O)NNc2ccc(C)c(Cl)c2)cc1 nan
CHEMBL1427235 34322 None 5 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 4 2 2 4.0 CCc1ccc(C(=O)NNc2ccc(C)c(Cl)c2)cc1 nan
2896074 45658 None 8 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 491 3 2 7 5.2 O=C1Nc2ccc(F)cc2C12Nc1ccccc1-c1nnc(SCc3ccccc3Cl)nc1O2 nan
CHEMBL1529705 45658 None 8 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 491 3 2 7 5.2 O=C1Nc2ccc(F)cc2C12Nc1ccccc1-c1nnc(SCc3ccccc3Cl)nc1O2 nan
2813088 48544 None 5 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 290 3 2 5 2.9 Cc1nnsc1C(=O)NNc1ccc(C(C)(C)C)cc1 nan
CHEMBL1556712 48544 None 5 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 290 3 2 5 2.9 Cc1nnsc1C(=O)NNc1ccc(C(C)(C)C)cc1 nan
6887818 108135 None 5 Human Functional pIC50 = 5.6 5.6 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 430 4 1 4 4.8 O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Br)cc2)nc2ccccc12 nan
CHEMBL3195898 108135 None 5 Human Functional pIC50 = 5.6 5.6 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 430 4 1 4 4.8 O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Br)cc2)nc2ccccc12 nan
2883150 50946 None 14 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 413 9 2 7 2.7 CC(=O)Nc1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 nan
CHEMBL1577988 50946 None 14 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 413 9 2 7 2.7 CC(=O)Nc1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 nan
14956788 107028 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 447 9 2 8 2.9 CCCCc1nn(C(C)C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315469 107028 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 447 9 2 8 2.9 CCCCc1nn(C(C)C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
2321121 55452 None 2 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 557 7 1 5 6.3 O=C(C[n+]1ccc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc3n2)cc1)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1412385 55452 None 2 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 557 7 1 5 6.3 O=C(C[n+]1ccc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc3n2)cc1)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1619819 55452 None 2 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 557 7 1 5 6.3 O=C(C[n+]1ccc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc3n2)cc1)c1cccc([N+](=O)[O-])c1 nan
2378336 36121 None 2 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 271 6 2 4 2.5 COc1ccc(C(=O)CNc2ccccc2CO)cc1 nan
CHEMBL1444275 36121 None 2 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 271 6 2 4 2.5 COc1ccc(C(=O)CNc2ccccc2CO)cc1 nan
3118009 44643 None 10 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 386 6 0 7 1.4 O=C(CN1C(=O)C2C3CCC(C3)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1520643 44643 None 10 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 386 6 0 7 1.4 O=C(CN1C(=O)C2C3CCC(C3)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
135492609 108254 None 5 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 521 2 1 7 3.6 CN1/C(=c2/s/c(=C3/C(=O)N(c4ccccc4)N=C3Nc3ccccc3)n(C)c2=O)C(C)(C)c2ccccc21 nan
CHEMBL3197135 108254 None 5 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 521 2 1 7 3.6 CN1/C(=c2/s/c(=C3/C(=O)N(c4ccccc4)N=C3Nc3ccccc3)n(C)c2=O)C(C)(C)c2ccccc21 nan
183134 204842 None 17 Bovine Functional pIC50 = 7.6 7.6 -134 7
Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80366-2
CHEMBL7550 204842 None 17 Bovine Functional pIC50 = 7.6 7.6 -134 7
Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80366-2
11527144 179103 None 0 Bovine Functional pIC50 = 7.6 7.6 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL297425 179103 None 0 Bovine Functional pIC50 = 7.6 7.6 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL47177 179103 None 0 Bovine Functional pIC50 = 7.6 7.6 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
14956749 206216 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.8 CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86613 206216 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.8 CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956803 206283 None 0 Rabbit Functional pIC50 = 7.6 7.6 10 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 515 9 1 7 5.5 CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86986 206283 None 0 Rabbit Functional pIC50 = 7.6 7.6 10 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 515 9 1 7 5.5 CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956767 206385 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 483 7 1 7 4.5 O=c1n(-c2ccccc2Cl)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87650 206385 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 483 7 1 7 4.5 O=c1n(-c2ccccc2Cl)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
54500223 70870 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 444 8 2 7 3.0 CCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951124 70870 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 444 8 2 7 3.0 CCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
324450 40913 None 25 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 219 3 2 3 1.4 O=C(CCl)NNc1cccc(Cl)n1 nan
CHEMBL1486528 40913 None 25 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 219 3 2 3 1.4 O=C(CCl)NNc1cccc(Cl)n1 nan
3103390 44837 None 11 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 410 7 1 7 2.1 O=C(CNC(=O)c1ccc(Br)o1)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1522230 44837 None 11 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 410 7 1 7 2.1 O=C(CNC(=O)c1ccc(Br)o1)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
1231596 35848 None 13 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 4 1 7 4.2 COc1cc(/C=C2\SC(=O)N(c3cccc(Cl)c3)C2=O)cc([N+](=O)[O-])c1O nan
CHEMBL1441794 35848 None 13 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 4 1 7 4.2 COc1cc(/C=C2\SC(=O)N(c3cccc(Cl)c3)C2=O)cc([N+](=O)[O-])c1O nan
9653430 71745 None 3 Human Functional pIC50 = 4.6 4.6 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 331 3 2 3 4.2 COc1cccc(NC(=S)N/N=C2\CC3CCC2(C)C3(C)C)c1 nan
CHEMBL1966283 71745 None 3 Human Functional pIC50 = 4.6 4.6 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 331 3 2 3 4.2 COc1cccc(NC(=S)N/N=C2\CC3CCC2(C)C3(C)C)c1 nan
161167 95489 None 40 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 284 3 1 3 3.0 O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 nan
CHEMBL257286 95489 None 40 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 284 3 1 3 3.0 O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 nan
3235730 52139 None 12 Human Functional pIC50 = 4.6 4.6 -2 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 432 8 1 9 3.4 CCSC1(SCC)N=C(N)C2(C#N)C(c3ccc(OC)c(OC)c3OC)C12C#N nan
CHEMBL1587831 52139 None 12 Human Functional pIC50 = 4.6 4.6 -2 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 432 8 1 9 3.4 CCSC1(SCC)N=C(N)C2(C#N)C(c3ccc(OC)c(OC)c3OC)C12C#N nan
793994 107700 None 7 Human Functional pIC50 = 5.6 5.6 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 304 2 1 4 4.9 Oc1c(/C=N/c2cccc3cccnc23)sc2ccccc12 nan
CHEMBL3190827 107700 None 7 Human Functional pIC50 = 5.6 5.6 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 304 2 1 4 4.9 Oc1c(/C=N/c2cccc3cccnc23)sc2ccccc12 nan
135444079 39141 None 14 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 270 1 1 2 3.7 Cc1cccc2c1NC(=O)C2=Nc1ccc(Cl)cc1 nan
CHEMBL1469448 39141 None 14 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 270 1 1 2 3.7 Cc1cccc2c1NC(=O)C2=Nc1ccc(Cl)cc1 nan
2412176 54903 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 5 1 3 3.1 COc1ccc(C(=O)CNc2cccc(F)c2)cc1 nan
CHEMBL1613520 54903 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 5 1 3 3.1 COc1ccc(C(=O)CNc2cccc(F)c2)cc1 nan
10411101 165663 None 0 Rabbit Functional pIC50 = 7.6 7.6 676 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 442 7 2 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 10.1021/jm00078a014
CHEMBL424465 165663 None 0 Rabbit Functional pIC50 = 7.6 7.6 676 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 442 7 2 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 10.1021/jm00078a014
10371403 66920 None 20 Rabbit Functional pIC50 = 5.6 5.6 - 1
Vasorelaxing potency was determinedVasorelaxing potency was determined
ChEMBL 601 13 1 10 5.8 CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm049681p
CHEMBL186572 66920 None 20 Rabbit Functional pIC50 = 5.6 5.6 - 1
Vasorelaxing potency was determinedVasorelaxing potency was determined
ChEMBL 601 13 1 10 5.8 CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm049681p
3119388 47334 None 12 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 556 7 0 7 2.5 O=C(CCN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1544373 47334 None 12 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 556 7 0 7 2.5 O=C(CCN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
4691872 47256 None 1 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 372 5 1 6 2.8 COC(=O)C1NN=C(C(=O)c2ccc(Cl)cc2)C1c1ccc(OC)cc1 nan
CHEMBL1543866 47256 None 1 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 372 5 1 6 2.8 COC(=O)C1NN=C(C(=O)c2ccc(Cl)cc2)C1c1ccc(OC)cc1 nan
135557876 108253 None 4 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 326 4 3 6 2.4 Cc1ncc(CO)c(/C=N/Nc2ccc(C(F)(F)F)cn2)c1O nan
CHEMBL3197126 108253 None 4 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 326 4 3 6 2.4 Cc1ncc(CO)c(/C=N/Nc2ccc(C(F)(F)F)cn2)c1O nan
2767330 96372 None 26 Human Functional pIC50 = 5.5 5.5 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 272 1 0 3 3.7 Cc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 nan
CHEMBL261693 96372 None 26 Human Functional pIC50 = 5.5 5.5 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 272 1 0 3 3.7 Cc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 nan
852940 49839 None 12 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 257 2 1 5 3.0 CCc1cc2c(O)nc(-c3ccccn3)nc2s1 nan
CHEMBL1567827 49839 None 12 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 257 2 1 5 3.0 CCc1cc2c(O)nc(-c3ccccn3)nc2s1 nan
3138587 34517 None 3 Human Functional pIC50 = 4.5 4.5 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 391 6 5 10 -2.3 CN(C)c1ccc2nc3c(=O)[nH]c(=O)nc-3n(CC(O)C(O)C(O)CO)c2c1 nan
CHEMBL1428985 34517 None 3 Human Functional pIC50 = 4.5 4.5 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 391 6 5 10 -2.3 CN(C)c1ccc2nc3c(=O)[nH]c(=O)nc-3n(CC(O)C(O)C(O)CO)c2c1 nan
1472222 28688 None 11 Human Functional pIC50 = 5.5 5.5 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 414 7 1 5 3.6 COc1ccc(C[S+]([O-])/C(Cl)=C(/Cl)C(=O)Nc2ccc(OC)nc2)cc1 nan
CHEMBL1377737 28688 None 11 Human Functional pIC50 = 5.5 5.5 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 414 7 1 5 3.6 COc1ccc(C[S+]([O-])/C(Cl)=C(/Cl)C(=O)Nc2ccc(OC)nc2)cc1 nan
135443160 31715 None 6 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 435 2 1 5 4.5 O=C1Nc2ccc(Br)cc2C1=Nc1ccc(-c2nnc3n2CCCCC3)cc1 nan
CHEMBL1405610 31715 None 6 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 435 2 1 5 4.5 O=C1Nc2ccc(Br)cc2C1=Nc1ccc(-c2nnc3n2CCCCC3)cc1 nan
2920316 37672 None 9 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 446 9 1 6 3.6 Cc1ccc(C(=O)COC(=O)CNC(=O)C(c2ccccc2)c2ccccc2)cc1[N+](=O)[O-] nan
CHEMBL1457414 37672 None 9 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 446 9 1 6 3.6 Cc1ccc(C(=O)COC(=O)CNC(=O)C(c2ccccc2)c2ccccc2)cc1[N+](=O)[O-] nan
4146306 25217 None 2 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 347 2 1 4 3.3 O=c1c2cc(Br)ccc2[nH]c(=S)n1Cc1ccccn1 nan
CHEMBL1348215 25217 None 2 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 347 2 1 4 3.3 O=c1c2cc(Br)ccc2[nH]c(=S)n1Cc1ccccn1 nan
1610 2345 None 95 Rabbit Functional pIC50 = 8.5 8.5 -19 11
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80348-6
3941 2345 None 95 Rabbit Functional pIC50 = 8.5 8.5 -19 11
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80348-6
3961 2345 None 95 Rabbit Functional pIC50 = 8.5 8.5 -19 11
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80348-6
590 2345 None 95 Rabbit Functional pIC50 = 8.5 8.5 -19 11
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80348-6
CHEMBL191 2345 None 95 Rabbit Functional pIC50 = 8.5 8.5 -19 11
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80348-6
DB00678 2345 None 95 Rabbit Functional pIC50 = 8.5 8.5 -19 11
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80348-6
20081616 92238 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 500 6 2 8 5.3 Cc1cc(O)nnc1-c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
CHEMBL24266 92238 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 500 6 2 8 5.3 Cc1cc(O)nnc1-c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
44459656 99624 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 561 8 1 8 3.9 CCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
CHEMBL2079789 99624 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 561 8 1 8 3.9 CCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
CHEMBL284140 99624 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 561 8 1 8 3.9 CCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
14956814 205798 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 10 1 7 4.8 CC(C)CCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL83194 205798 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 10 1 7 4.8 CC(C)CCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971703 107086 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL315878 107086 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956761 105969 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 494 9 1 8 4.3 CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313025 105969 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 494 9 1 8 4.3 CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956778 206291 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 9 1 7 3.9 CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87057 206291 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 9 1 7 3.9 CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44320509 206336 None 0 Rabbit Functional pIC50 = 8.5 8.5 1 2
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 465 6 2 6 5.5 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 10.1021/jm0603163
CHEMBL87327 206336 None 0 Rabbit Functional pIC50 = 8.5 8.5 1 2
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 465 6 2 6 5.5 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 10.1021/jm0603163
22942224 70883 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 583 11 1 9 3.9 CCCCc1nc(C)c(CCC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951137 70883 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 583 11 1 9 3.9 CCCCc1nc(C)c(CCC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
44292471 157550 None 0 Bovine Functional pIC50 = 8.5 8.5 - 1
Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.
ChEMBL 563 10 3 8 5.0 CCCCc1nc2ccc(C(C)(O)C[C@H]3CCCN3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80366-2
CHEMBL408033 157550 None 0 Bovine Functional pIC50 = 8.5 8.5 - 1
Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.
ChEMBL 563 10 3 8 5.0 CCCCc1nc2ccc(C(C)(O)C[C@H]3CCCN3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80366-2
54277224 70879 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 540 9 1 8 3.1 CCCCc1nc(C)c(CC(=O)N2CCN(C)CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951133 70879 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 540 9 1 8 3.1 CCCCc1nc(C)c(CC(=O)N2CCN(C)CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971718 15530 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 388 7 3 5 3.5 CCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL121847 15530 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 388 7 3 5 3.5 CCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956753 107068 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 527 9 1 7 5.9 CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315776 107068 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 527 9 1 7 5.9 CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971721 113181 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 544 8 2 6 6.3 O=C(O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl 10.1021/jm00075a014
CHEMBL331475 113181 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 544 8 2 6 6.3 O=C(O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl 10.1021/jm00075a014
4673492 4136 None 9 Guinea pig Functional pIC50 = 8.4 8.4 5248 2
In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneIn vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membrane
ChEMBL 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 10.1021/jm9504722
8324 4136 None 9 Guinea pig Functional pIC50 = 8.4 8.4 5248 2
In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneIn vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membrane
ChEMBL 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 10.1021/jm9504722
CHEMBL159096 4136 None 9 Guinea pig Functional pIC50 = 8.4 8.4 5248 2
In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneIn vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membrane
ChEMBL 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 10.1021/jm9504722
14971689 12206 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 10 1 7 5.4 CCCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL118431 12206 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 10 1 7 5.4 CCCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
44211605 170758 None 0 Bovine Functional pIC50 = 7.5 7.5 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 577 10 1 10 5.0 CCCCc1nc2ccc(C3CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL44526 170758 None 0 Bovine Functional pIC50 = 7.5 7.5 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 577 10 1 10 5.0 CCCCc1nc2ccc(C3CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
14956809 106190 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 656 15 1 9 6.5 CCCCc1nn(CCCN(Cc2ccccc2)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313837 106190 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 656 15 1 9 6.5 CCCCc1nn(CCCN(Cc2ccccc2)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
132562 99681 None 6 Guinea pig Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneIn vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membrane
ChEMBL 407 6 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm9504722
CHEMBL284536 99681 None 6 Guinea pig Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneIn vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membrane
ChEMBL 407 6 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm9504722
57403666 70868 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 472 9 1 8 3.5 CCOC(=O)CCc1c(C)nc(CC)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c1=O 10.1016/j.bmcl.2011.12.116
CHEMBL1951122 70868 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 472 9 1 8 3.5 CCOC(=O)CCc1c(C)nc(CC)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c1=O 10.1016/j.bmcl.2011.12.116
57396698 70873 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 513 11 1 7 4.2 CCCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951127 70873 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 513 11 1 7 4.2 CCCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
6918269 98468 None 11 Bovine Functional pIC50 = 7.5 7.5 -5 2
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL275875 98468 None 11 Bovine Functional pIC50 = 7.5 7.5 -5 2
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL295959 98468 None 11 Bovine Functional pIC50 = 7.5 7.5 -5 2
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
10027636 24592 None 0 Rabbit Functional pIC50 = 7.5 7.5 70 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 468 9 1 5 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL134286 24592 None 0 Rabbit Functional pIC50 = 7.5 7.5 70 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 468 9 1 5 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
135406019 24031 None 15 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 264 2 1 3 3.0 CC(=O)c1ccc(N=C2C(=O)Nc3ccccc32)cc1 nan
CHEMBL1338100 24031 None 15 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 264 2 1 3 3.0 CC(=O)c1ccc(N=C2C(=O)Nc3ccccc32)cc1 nan
3395163 29835 None 5 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 441 11 1 7 3.5 CSCCC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 nan
CHEMBL1387520 29835 None 5 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 441 11 1 7 3.5 CSCCC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 nan
16012865 23339 None 9 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 480 6 1 7 2.6 CN(c1ccccc1)S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 nan
CHEMBL1332454 23339 None 9 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 480 6 1 7 2.6 CN(c1ccccc1)S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 nan
67903275 186521 None 5 Human Functional pIC50 = 7.5 7.5 257 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 402 7 1 5 4.2 CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL4877651 186521 None 5 Human Functional pIC50 = 7.5 7.5 257 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 402 7 1 5 4.2 CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
142534170 166802 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 591 9 1 7 5.8 CCCCc1nc(C)c(CC(=S)N2Cc3ccccc3C2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4284403 166802 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 591 9 1 7 5.8 CCCCc1nc(C)c(CC(=S)N2Cc3ccccc3C2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
44292039 182091 None 1 Bovine Functional pIC50 = 7.5 7.5 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 547 8 1 8 5.5 CCCCc1nc2ccc([C@@H]3C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL47817 182091 None 1 Bovine Functional pIC50 = 7.5 7.5 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 547 8 1 8 5.5 CCCCc1nc2ccc([C@@H]3C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
14956801 206108 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 555 9 1 7 5.0 CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85765 206108 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 555 9 1 7 5.0 CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10251520 98819 None 0 Rabbit Functional pIC50 = 6.5 6.5 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 419 5 0 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C#N)c1 10.1021/jm00078a013
CHEMBL278656 98819 None 0 Rabbit Functional pIC50 = 6.5 6.5 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 419 5 0 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C#N)c1 10.1021/jm00078a013
5731496 53181 None 9 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 281 2 1 2 4.8 Oc1cccc2ccc(/C=C/c3ccccc3Cl)nc12 nan
CHEMBL1598569 53181 None 9 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 281 2 1 2 4.8 Oc1cccc2ccc(/C=C/c3ccccc3Cl)nc12 nan
1613606 48021 None 12 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 392 8 1 7 1.6 Cc1ccc(C(=O)COC(=O)CNS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-] nan
CHEMBL1550301 48021 None 12 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 392 8 1 7 1.6 Cc1ccc(C(=O)COC(=O)CNS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-] nan
44417426 141574 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 469 6 2 5 5.1 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2c3ccccc3C(C)(O)C2C(=O)O)cc1 10.1021/jm0603163
CHEMBL384936 141574 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 469 6 2 5 5.1 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2c3ccccc3C(C)(O)C2C(=O)O)cc1 10.1021/jm0603163
14956751 206299 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 9 1 9 4.1 CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87073 206299 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 9 1 9 4.1 CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956802 206313 None 0 Rabbit Functional pIC50 = 7.5 7.5 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 515 9 1 7 5.5 CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87184 206313 None 0 Rabbit Functional pIC50 = 7.5 7.5 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 515 9 1 7 5.5 CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1610 2345 None 95 Bovine Functional pIC50 = 6.5 6.5 -134 11
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80365-0
3941 2345 None 95 Bovine Functional pIC50 = 6.5 6.5 -134 11
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80365-0
3961 2345 None 95 Bovine Functional pIC50 = 6.5 6.5 -134 11
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80365-0
590 2345 None 95 Bovine Functional pIC50 = 6.5 6.5 -134 11
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80365-0
CHEMBL191 2345 None 95 Bovine Functional pIC50 = 6.5 6.5 -134 11
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80365-0
DB00678 2345 None 95 Bovine Functional pIC50 = 6.5 6.5 -134 11
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80365-0
44355656 116082 None 0 Rabbit Functional pIC50 = 5.5 5.5 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 467 6 1 6 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2NC(=O)OC)c1 10.1021/jm00078a013
CHEMBL335680 116082 None 0 Rabbit Functional pIC50 = 5.5 5.5 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 467 6 1 6 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2NC(=O)OC)c1 10.1021/jm00078a013
44202070 39616 None 0 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 271 1 0 2 3.5 Cc1ccc2c(c1)C(=O)C(=O)N2c1ccc(Cl)cc1 nan
CHEMBL1474191 39616 None 0 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 271 1 0 2 3.5 Cc1ccc2c(c1)C(=O)C(=O)N2c1ccc(Cl)cc1 nan
1730709 24038 None 12 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 370 8 1 6 3.0 Cc1ccccc1NC(=O)CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1338165 24038 None 12 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 370 8 1 6 3.0 Cc1ccccc1NC(=O)CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
2899190 52549 None 9 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 386 6 0 7 1.6 Cc1ccc(C(=O)COC(=O)CN2C(=O)C3CC=CCC3C2=O)cc1[N+](=O)[O-] nan
CHEMBL1592181 52549 None 9 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 386 6 0 7 1.6 Cc1ccc(C(=O)COC(=O)CN2C(=O)C3CC=CCC3C2=O)cc1[N+](=O)[O-] nan
2285607 38559 None 10 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 400 9 1 7 3.1 COc1ccccc1NC(=O)CCC(=O)OCC(=O)c1ccc(C)c([N+](=O)[O-])c1 nan
CHEMBL1464749 38559 None 10 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 400 9 1 7 3.1 COc1ccccc1NC(=O)CCC(=O)OCC(=O)c1ccc(C)c([N+](=O)[O-])c1 nan
44201736 27460 None 0 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 586 9 2 5 5.2 O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1 nan
CHEMBL1368499 27460 None 0 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 586 9 2 5 5.2 O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1 nan
16195321 51040 None 4 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 413 6 0 5 4.9 CN(C)CCN(Cc1ccco1)C(=O)c1cc2c(Cl)nc3ccccc3c2s1 nan
CHEMBL1578651 51040 None 4 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 413 6 0 5 4.9 CN(C)CCN(Cc1ccco1)C(=O)c1cc2c(Cl)nc3ccccc3c2s1 nan
10344571 116612 None 0 Rabbit Functional pIC50 = 7.5 7.5 125 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 468 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336773 116612 None 0 Rabbit Functional pIC50 = 7.5 7.5 125 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 468 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
4210369 42428 None 12 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 424 8 1 6 4.0 O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1cccc(Cl)c1Cl nan
CHEMBL1499072 42428 None 12 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 424 8 1 6 4.0 O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1cccc(Cl)c1Cl nan
1726742 33393 None 13 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 398 9 1 7 2.9 CC(=O)c1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 nan
CHEMBL1419495 33393 None 13 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 398 9 1 7 2.9 CC(=O)c1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 nan
9548123 47762 None 0 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 378 3 1 5 3.1 COc1ccc2c(c1)C(=O)[C@@H](O)[C@H](c1ccc(OC)c(Br)c1)O2 nan
CHEMBL1548173 47762 None 0 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 378 3 1 5 3.1 COc1ccc2c(c1)C(=O)[C@@H](O)[C@H](c1ccc(OC)c(Br)c1)O2 nan
5416363 108181 None 3 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 295 3 1 3 3.5 C/C(=N/NC(=O)c1ccc(C(C)(C)C)cc1)c1ccccn1 nan
CHEMBL3196324 108181 None 3 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 295 3 1 3 3.5 C/C(=N/NC(=O)c1ccc(C(C)(C)C)cc1)c1ccccn1 nan
44292214 175888 None 0 Bovine Functional pIC50 = 7.5 7.5 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 577 9 2 9 4.6 CCCCc1nc2ccc([C@]3(CO)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL45864 175888 None 0 Bovine Functional pIC50 = 7.5 7.5 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 577 9 2 9 4.6 CCCCc1nc2ccc([C@]3(CO)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
10364891 26243 None 0 Rabbit Functional pIC50 = 6.5 6.5 33 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 421 5 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 10.1021/jm00078a013
CHEMBL135792 26243 None 0 Rabbit Functional pIC50 = 6.5 6.5 33 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 421 5 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 10.1021/jm00078a013
9550553 54519 None 6 Human Functional pIC50 = 5.5 5.5 2 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 445 8 1 11 4.3 CCC(=O)OCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] nan
CHEMBL1610025 54519 None 6 Human Functional pIC50 = 5.5 5.5 2 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 445 8 1 11 4.3 CCC(=O)OCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] nan
1266032 40876 None 6 Human Functional pIC50 = 5.5 5.5 3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 343 2 0 3 4.9 O=C(Sc1cccc2cccnc12)c1ccccc1Br nan
CHEMBL1486214 40876 None 6 Human Functional pIC50 = 5.5 5.5 3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 343 2 0 3 4.9 O=C(Sc1cccc2cccnc12)c1ccccc1Br nan
9608279 107788 None 6 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 366 6 1 8 3.1 COc1ccc(/C=N/Nc2cc(C)nc(-n3nc(C)cc3C)n2)c(OC)c1 nan
CHEMBL3191846 107788 None 6 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 366 6 1 8 3.1 COc1ccc(/C=N/Nc2cc(C)nc(-n3nc(C)cc3C)n2)c(OC)c1 nan
5341487 72349 None 15 Human Functional pIC50 = 5.5 5.5 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 317 3 1 3 3.0 C/C(=N\NC(=O)c1cccc(Br)c1)c1ccccn1 nan
CHEMBL1984876 72349 None 15 Human Functional pIC50 = 5.5 5.5 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 317 3 1 3 3.0 C/C(=N\NC(=O)c1cccc(Br)c1)c1ccccn1 nan
11100 125954 None 80 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 192 3 1 4 1.8 O=C(c1ccco1)C(O)c1ccco1 nan
CHEMBL364893 125954 None 80 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 192 3 1 4 1.8 O=C(c1ccco1)C(O)c1ccco1 nan
135472780 28444 None 7 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 2 1 4 5.0 Cc1ccc(N=Nc2ccc(O)c3ncccc23)cc1C nan
CHEMBL1375373 28444 None 7 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 2 1 4 5.0 Cc1ccc(N=Nc2ccc(O)c3ncccc23)cc1C nan
2360979 38948 None 7 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 275 5 1 3 3.6 COc1ccccc1NCC(=O)c1ccc(Cl)cc1 nan
CHEMBL1467838 38948 None 7 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 275 5 1 3 3.6 COc1ccccc1NCC(=O)c1ccc(Cl)cc1 nan
3106500 24787 None 9 Human Functional pIC50 = 4.5 4.5 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 306 3 1 7 1.5 CC1=NN(C(N)=S)C(=O)C1N=Nc1ccc([N+](=O)[O-])cc1 nan
CHEMBL1344603 24787 None 9 Human Functional pIC50 = 4.5 4.5 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 306 3 1 7 1.5 CC1=NN(C(N)=S)C(=O)C1N=Nc1ccc([N+](=O)[O-])cc1 nan
2431535 38921 None 6 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 343 4 0 4 4.1 O=C(COC(=O)c1cccnc1Cl)c1ccc(Cl)cc1Cl nan
CHEMBL1467556 38921 None 6 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 343 4 0 4 4.1 O=C(COC(=O)c1cccnc1Cl)c1ccc(Cl)cc1Cl nan
2324620 24897 None 14 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 455 4 4 4 4.3 CC(C)(C)c1cc(CCC(=O)NNC(=S)NC(=O)c2ccccc2)cc(C(C)(C)C)c1O nan
CHEMBL1345564 24897 None 14 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 455 4 4 4 4.3 CC(C)(C)c1cc(CCC(=O)NNC(=S)NC(=O)c2ccccc2)cc(C(C)(C)C)c1O nan
1875884 24502 None 7 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 436 5 3 6 3.0 COc1ccc(/C=C/C(=O)NC(=S)NNC(=O)c2c(-c3ccccc3)noc2C)cc1 nan
CHEMBL1342221 24502 None 7 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 436 5 3 6 3.0 COc1ccc(/C=C/C(=O)NC(=S)NNC(=O)c2c(-c3ccccc3)noc2C)cc1 nan
16012896 32997 None 10 Human Functional pIC50 = 5.5 5.5 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 494 7 1 7 3.0 CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N(C)c3ccccc3)cc2)n1 nan
CHEMBL1416089 32997 None 10 Human Functional pIC50 = 5.5 5.5 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 494 7 1 7 3.0 CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N(C)c3ccccc3)cc2)n1 nan
2352555 52370 None 6 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 4 0 4 3.4 O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccccn1 nan
CHEMBL1589900 52370 None 6 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 4 0 4 3.4 O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccccn1 nan
3146836 107656 None 9 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 399 4 1 6 5.6 CCOC(=O)C1=C(C)N=C2CC(c3cccs3)CC(O)=C2C1c1cccs1 nan
CHEMBL3190347 107656 None 9 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 399 4 1 6 5.6 CCOC(=O)C1=C(C)N=C2CC(c3cccs3)CC(O)=C2C1c1cccs1 nan
135400342 39764 None 7 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 293 4 2 7 2.2 O=[N+]([O-])c1ccc(O)c(/C=N/Nc2ccc(Cl)nn2)c1 nan
CHEMBL1476264 39764 None 7 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 293 4 2 7 2.2 O=[N+]([O-])c1ccc(O)c(/C=N/Nc2ccc(Cl)nn2)c1 nan
1612942 40834 None 9 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 370 7 1 6 2.4 Cc1ccc(C(=O)NCC(=O)OCC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1 nan
CHEMBL1485784 40834 None 9 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 370 7 1 6 2.4 Cc1ccc(C(=O)NCC(=O)OCC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1 nan
24818379 41096 None 5 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 353 6 2 8 1.3 COc1ccc(S(=O)(=O)NNc2nc(C)cc(C)n2)cc1[N+](=O)[O-] nan
CHEMBL1487991 41096 None 5 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 353 6 2 8 1.3 COc1ccc(S(=O)(=O)NNc2nc(C)cc(C)n2)cc1[N+](=O)[O-] nan
82533 41042 None 70 Human Functional pIC50 = 5.4 5.4 -6 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 298 3 1 3 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 nan
CHEMBL1487635 41042 None 70 Human Functional pIC50 = 5.4 5.4 -6 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 298 3 1 3 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 nan
5286934 49299 None 8 Human Functional pIC50 = 5.4 5.4 -2 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 294 9 0 4 2.4 CCCCS(=O)(=O)/C=C\C=C/S(=O)(=O)CCCC nan
CHEMBL1563483 49299 None 8 Human Functional pIC50 = 5.4 5.4 -2 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 294 9 0 4 2.4 CCCCS(=O)(=O)/C=C\C=C/S(=O)(=O)CCCC nan
930382 34007 None 12 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 4 0 4 3.4 O=C(COC(=O)c1cccnc1)c1ccc(Cl)c(Cl)c1 nan
CHEMBL1424582 34007 None 12 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 4 0 4 3.4 O=C(COC(=O)c1cccnc1)c1ccc(Cl)c(Cl)c1 nan
2811457 34419 None 5 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 4 2 4 3.2 Cc1noc(C)c1C(=O)NNc1ccc(C(C)C)cc1 nan
CHEMBL1428121 34419 None 5 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 4 2 4 3.2 Cc1noc(C)c1C(=O)NNc1ccc(C(C)C)cc1 nan
14971679 111649 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 608 10 1 7 7.8 CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL328598 111649 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 608 10 1 7 7.8 CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
108185 1612 None 78 Rat Functional pIC50 = 7.4 7.4 -3 5
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00057a009
586 1612 None 78 Rat Functional pIC50 = 7.4 7.4 -3 5
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00057a009
CHEMBL907 1612 None 78 Rat Functional pIC50 = 7.4 7.4 -3 5
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00057a009
108185 1612 None 78 Rabbit Functional pIC50 = 7.4 7.4 -3 5
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00069a015
586 1612 None 78 Rabbit Functional pIC50 = 7.4 7.4 -3 5
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00069a015
CHEMBL907 1612 None 78 Rabbit Functional pIC50 = 7.4 7.4 -3 5
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00069a015
14956783 205774 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 414 8 1 8 2.8 CCCCc1nn(CC#N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL82920 205774 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 414 8 1 8 2.8 CCCCc1nn(CC#N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
9612783 107922 None 3 Human Functional pIC50 = 5.4 5.4 2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 345 6 1 4 3.7 C/C(=N\NC(=O)COc1ccccc1-c1ccccc1)c1ccccn1 nan
CHEMBL3193378 107922 None 3 Human Functional pIC50 = 5.4 5.4 2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 345 6 1 4 3.7 C/C(=N\NC(=O)COc1ccccc1-c1ccccc1)c1ccccn1 nan
142534004 167356 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 557 9 1 7 5.3 CCCCc1nc(C)c(CC(=S)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4294618 167356 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 557 9 1 7 5.3 CCCCc1nc(C)c(CC(=S)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
15229102 101190 None 0 Bovine Functional pIC50 = 7.4 7.4 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 561 8 1 8 5.9 CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL295695 101190 None 0 Bovine Functional pIC50 = 7.4 7.4 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 561 8 1 8 5.9 CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
9982458 26507 None 0 Rabbit Functional pIC50 = 6.4 6.4 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 476 8 1 5 6.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2Cl)cc1 10.1021/jm00078a014
CHEMBL136034 26507 None 0 Rabbit Functional pIC50 = 6.4 6.4 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 476 8 1 5 6.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2Cl)cc1 10.1021/jm00078a014
1720698 19537 None 12 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 378 8 1 7 1.3 O=C(CNS(=O)(=O)c1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1299557 19537 None 12 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 378 8 1 7 1.3 O=C(CNS(=O)(=O)c1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
2812498 43641 None 5 Human Functional pIC50 = 5.4 5.4 2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 362 5 2 4 4.3 Cc1ccc(NNC(=O)c2cc(C(C)(C)C)nn2Cc2ccccc2)cc1 nan
CHEMBL1509694 43641 None 5 Human Functional pIC50 = 5.4 5.4 2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 362 5 2 4 4.3 Cc1ccc(NNC(=O)c2cc(C(C)(C)C)nn2Cc2ccccc2)cc1 nan
888488 50696 None 11 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 301 5 0 7 1.7 Cc1ccc(C(=O)COC(=O)c2cnccn2)cc1[N+](=O)[O-] nan
CHEMBL1575784 50696 None 11 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 301 5 0 7 1.7 Cc1ccc(C(=O)COC(=O)c2cnccn2)cc1[N+](=O)[O-] nan
2766929 50308 None 26 Human Functional pIC50 = 4.4 4.4 -20 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 1 0 4 3.1 CC(C)(C)c1ccc(-n2nc(C#N)c(Cl)cc2=O)cc1 nan
CHEMBL1572001 50308 None 26 Human Functional pIC50 = 4.4 4.4 -20 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 1 0 4 3.1 CC(C)(C)c1ccc(-n2nc(C#N)c(Cl)cc2=O)cc1 nan
130606 36268 None 54 Human Functional pIC50 = 5.4 5.4 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 328 4 1 4 3.4 COc1cc(NS(=O)(=O)c2ccc(C)cc2)c2ncccc2c1 nan
CHEMBL1445650 36268 None 54 Human Functional pIC50 = 5.4 5.4 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 328 4 1 4 3.4 COc1cc(NS(=O)(=O)c2ccc(C)cc2)c2ncccc2c1 nan
44292173 172450 None 0 Bovine Functional pIC50 = 7.4 7.4 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.3 CCCCc1nc2ccc([C@@H]3C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL44798 172450 None 0 Bovine Functional pIC50 = 7.4 7.4 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.3 CCCCc1nc2ccc([C@@H]3C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
164616479 185314 None 0 Human Functional pIC50 = 6.4 6.4 16 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 404 7 2 5 3.8 CCCCC1NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL4859498 185314 None 0 Human Functional pIC50 = 6.4 6.4 16 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 404 7 2 5 3.8 CCCCC1NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
2426323 37569 None 6 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 360 3 3 3 4.6 Cc1ccccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl nan
CHEMBL1456428 37569 None 6 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 360 3 3 3 4.6 Cc1ccccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl nan
1472216 50611 None 12 Human Functional pIC50 = 5.4 5.4 -3 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 384 6 1 4 3.6 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2)cn1 nan
CHEMBL1574879 50611 None 12 Human Functional pIC50 = 5.4 5.4 -3 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 384 6 1 4 3.6 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2)cn1 nan
135421501 49828 None 16 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 344 2 1 3 3.8 COc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 nan
CHEMBL1567702 49828 None 16 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 344 2 1 3 3.8 COc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 nan
16193016 56127 None 6 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 354 4 0 2 3.4 O=C(C[N+]1(CC#Cc2ccccc2)CCOCC1)c1ccc(Cl)cc1 nan
CHEMBL1602056 56127 None 6 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 354 4 0 2 3.4 O=C(C[N+]1(CC#Cc2ccccc2)CCOCC1)c1ccc(Cl)cc1 nan
CHEMBL1625597 56127 None 6 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 354 4 0 2 3.4 O=C(C[N+]1(CC#Cc2ccccc2)CCOCC1)c1ccc(Cl)cc1 nan
3368605 19819 None 9 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 504 5 0 6 5.4 O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccc2c(c1)C(=O)N(c1cccc3ncccc13)C2=O nan
CHEMBL1301939 19819 None 9 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 504 5 0 6 5.4 O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccc2c(c1)C(=O)N(c1cccc3ncccc13)C2=O nan
2114872 20781 None 6 Human Functional pIC50 = 5.4 5.4 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 2 1 4 3.1 O=C(Nc1nc2ccc(F)cc2s1)c1ccccn1 nan
CHEMBL1309573 20781 None 6 Human Functional pIC50 = 5.4 5.4 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 2 1 4 3.1 O=C(Nc1nc2ccc(F)cc2s1)c1ccccn1 nan
2928370 45465 None 8 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 356 5 1 5 3.2 CCOC(=O)C1=NNC(C(=O)c2ccc(Cl)cc2)C1c1ccccc1 nan
CHEMBL1528033 45465 None 8 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 356 5 1 5 3.2 CCOC(=O)C1=NNC(C(=O)c2ccc(Cl)cc2)C1c1ccccc1 nan
135426090 34344 None 12 Human Functional pIC50 = 5.4 5.4 3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 318 3 2 6 4.0 Cc1ccc2oc(Nc3nc(O)cc(-c4ccccc4)n3)nc2c1 nan
CHEMBL1427431 34344 None 12 Human Functional pIC50 = 5.4 5.4 3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 318 3 2 6 4.0 Cc1ccc2oc(Nc3nc(O)cc(-c4ccccc4)n3)nc2c1 nan
135632169 51667 None 8 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 419 5 2 7 2.4 O=C1N=C(NS(=O)(=O)Cc2ccccc2)S/C1=C/c1cc([N+](=O)[O-])ccc1O nan
136087362 51667 None 8 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 419 5 2 7 2.4 O=C1N=C(NS(=O)(=O)Cc2ccccc2)S/C1=C/c1cc([N+](=O)[O-])ccc1O nan
CHEMBL1583998 51667 None 8 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 419 5 2 7 2.4 O=C1N=C(NS(=O)(=O)Cc2ccccc2)S/C1=C/c1cc([N+](=O)[O-])ccc1O nan
10456041 25853 None 0 Rabbit Functional pIC50 = 8.4 8.4 186 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 442 8 1 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135346 25853 None 0 Rabbit Functional pIC50 = 8.4 8.4 186 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 442 8 1 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
44459595 99455 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 516 6 2 7 5.1 CC1(C)CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
CHEMBL2079785 99455 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 516 6 2 7 5.1 CC1(C)CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
CHEMBL283055 99455 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 516 6 2 7 5.1 CC1(C)CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
44459878 99705 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 574 8 1 9 4.6 COC(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)CC1=O 10.1016/S0960-894X(01)80348-6
CHEMBL284704 99705 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 574 8 1 9 4.6 COC(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)CC1=O 10.1016/S0960-894X(01)80348-6
53657506 70884 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 557 10 1 8 4.3 CCCCc1nc(C)c(CCC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951138 70884 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 557 10 1 8 4.3 CCCCc1nc(C)c(CCC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14956738 205796 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL83180 205796 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
9870652 70890 None 75 Human Functional pIC50 = 8.4 8.4 -15 2
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL1951143 70890 None 75 Human Functional pIC50 = 8.4 8.4 -15 2
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2018.08.036
DB09279 70890 None 75 Human Functional pIC50 = 8.4 8.4 -15 2
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2018.08.036
11974939 82137 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 466 5 1 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)n(C)c(=O)c3ccccc23)cc1 10.1021/jm0603163
CHEMBL216747 82137 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 466 5 1 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)n(C)c(=O)c3ccccc23)cc1 10.1021/jm0603163
10183373 165008 None 0 Rabbit Functional pIC50 = 8.3 8.3 3 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 9 1 7 4.3 CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL422593 165008 None 0 Rabbit Functional pIC50 = 8.3 8.3 3 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 9 1 7 4.3 CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10183373 165008 None 0 Rabbit Functional pIC50 = 8.3 8.3 3 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 9 1 7 4.3 CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL422593 165008 None 0 Rabbit Functional pIC50 = 8.3 8.3 3 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 9 1 7 4.3 CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
54199501 70865 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 486 10 1 8 3.9 CCCCc1nc(C)c(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951119 70865 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 486 10 1 8 3.9 CCCCc1nc(C)c(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
54558598 70874 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 499 10 1 7 3.8 CCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951128 70874 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 499 10 1 7 3.8 CCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
142534183 167267 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 503 8 1 7 4.0 CCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4293170 167267 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 503 8 1 7 4.0 CCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14956794 206076 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.9 CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85545 206076 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.9 CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1610 2345 None 95 Rabbit Functional pIC50 = 7.4 7.4 -19 11
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a014
3941 2345 None 95 Rabbit Functional pIC50 = 7.4 7.4 -19 11
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a014
3961 2345 None 95 Rabbit Functional pIC50 = 7.4 7.4 -19 11
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a014
590 2345 None 95 Rabbit Functional pIC50 = 7.4 7.4 -19 11
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a014
CHEMBL191 2345 None 95 Rabbit Functional pIC50 = 7.4 7.4 -19 11
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a014
DB00678 2345 None 95 Rabbit Functional pIC50 = 7.4 7.4 -19 11
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a014
5335625 108691 None 10 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 293 3 1 3 3.2 O=C(N/N=C/c1ccccn1)c1ccc(Cl)c(Cl)c1 nan
CHEMBL3208035 108691 None 10 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 293 3 1 3 3.2 O=C(N/N=C/c1ccccn1)c1ccc(Cl)c(Cl)c1 nan
46495021 107826 None 5 Human Functional pIC50 = 5.4 5.4 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 315 5 1 7 1.7 O=C(N/N=C/c1ccccn1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1 nan
CHEMBL3192235 107826 None 5 Human Functional pIC50 = 5.4 5.4 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 315 5 1 7 1.7 O=C(N/N=C/c1ccccn1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1 nan
14971636 114811 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 10 1 7 6.0 CCCCc1nc(-c2ccccc2)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL334083 114811 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 10 1 7 6.0 CCCCc1nc(-c2ccccc2)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
44292040 101133 None 0 Bovine Functional pIC50 = 6.4 6.4 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 601 9 1 9 6.9 CCCCc1nc2ccc(C3CC(c4cc(C)cs4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL295279 101133 None 0 Bovine Functional pIC50 = 6.4 6.4 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 601 9 1 9 6.9 CCCCc1nc2ccc(C3CC(c4cc(C)cs4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
5759185 38675 None 5 Human Functional pIC50 = 5.4 5.4 -5 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 4 0 6 2.8 CC(C)(C)C(=O)/C(=C\c1cccc([N+](=O)[O-])c1)n1cncn1 nan
CHEMBL1465592 38675 None 5 Human Functional pIC50 = 5.4 5.4 -5 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 4 0 6 2.8 CC(C)(C)C(=O)/C(=C\c1cccc([N+](=O)[O-])c1)n1cncn1 nan
5217512 42398 None 5 Human Functional pIC50 = 5.4 5.4 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 278 3 3 5 2.8 NNc1nc(-c2ccccc2)cc(-c2ccccc2O)n1 nan
CHEMBL1498886 42398 None 5 Human Functional pIC50 = 5.4 5.4 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 278 3 3 5 2.8 NNc1nc(-c2ccccc2)cc(-c2ccccc2O)n1 nan
10371403 66920 None 20 Rabbit Functional pIC50 = 5.4 5.4 - 1
Vasorelaxing potency in the presence of eserin was determinedVasorelaxing potency in the presence of eserin was determined
ChEMBL 601 13 1 10 5.8 CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm049681p
CHEMBL186572 66920 None 20 Rabbit Functional pIC50 = 5.4 5.4 - 1
Vasorelaxing potency in the presence of eserin was determinedVasorelaxing potency in the presence of eserin was determined
ChEMBL 601 13 1 10 5.8 CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm049681p
14956743 164103 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL420970 164103 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
56991879 70867 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 528 13 1 8 4.9 CCCCc1nc(CCC)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951121 70867 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 528 13 1 8 4.9 CCCCc1nc(CCC)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
9618012 77916 None 4 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 289 3 1 3 3.4 C/C(=N\NC(=O)c1cccc2ccccc12)c1ccccn1 nan
CHEMBL2094484 77916 None 4 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 289 3 1 3 3.4 C/C(=N\NC(=O)c1cccc2ccccc12)c1ccccn1 nan
1475345 29234 None 11 Human Functional pIC50 = 5.3 5.3 -1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 418 6 1 4 4.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2Cl)cn1 nan
CHEMBL1382438 29234 None 11 Human Functional pIC50 = 5.3 5.3 -1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 418 6 1 4 4.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2Cl)cn1 nan
18666499 175617 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 591 9 2 9 4.7 CCCCc1nc2ccc([C@]3(C(=O)O)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL45805 175617 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 591 9 2 9 4.7 CCCCc1nc2ccc([C@]3(C(=O)O)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
11743704 115496 None 0 Rabbit Functional pIC50 = 5.3 5.3 3 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 10.1021/jm00078a013
CHEMBL335179 115496 None 0 Rabbit Functional pIC50 = 5.3 5.3 3 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 10.1021/jm00078a013
44292038 182533 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.0 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL47873 182533 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.0 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
5218417 24812 None 6 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 285 3 0 2 3.9 CC1CCCN(CC(=O)c2ccc(Cl)c(Cl)c2)C1 nan
CHEMBL1344824 24812 None 6 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 285 3 0 2 3.9 CC1CCCN(CC(=O)c2ccc(Cl)c(Cl)c2)C1 nan
10411653 24422 None 0 Rabbit Functional pIC50 = 7.3 7.3 208 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 454 5 1 5 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O 10.1021/jm00078a013
CHEMBL134151 24422 None 0 Rabbit Functional pIC50 = 7.3 7.3 208 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 454 5 1 5 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O 10.1021/jm00078a013
14956799 106897 None 0 Rabbit Functional pIC50 = 6.3 6.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314590 106897 None 0 Rabbit Functional pIC50 = 6.3 6.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
6873617 72415 None 5 Human Functional pIC50 = 5.3 5.3 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 386 4 1 4 4.7 O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Cl)cc2)nc2ccccc12 nan
CHEMBL1987579 72415 None 5 Human Functional pIC50 = 5.3 5.3 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 386 4 1 4 4.7 O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Cl)cc2)nc2ccccc12 nan
10367704 22341 None 0 Rabbit Functional pIC50 = 8.3 8.3 25 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
CHEMBL132408 22341 None 0 Rabbit Functional pIC50 = 8.3 8.3 25 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
131654 206401 None 12 Rabbit Functional pIC50 = 8.3 8.3 1 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87778 206401 None 12 Rabbit Functional pIC50 = 8.3 8.3 1 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956748 205971 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL84627 205971 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
9887844 163198 None 4 Guinea pig Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneIn vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membrane
ChEMBL 411 6 1 5 4.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1021/jm9504722
CHEMBL418226 163198 None 4 Guinea pig Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneIn vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membrane
ChEMBL 411 6 1 5 4.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1021/jm9504722
54393565 70885 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 541 10 1 8 3.6 CCCCc1nc(C)c(CCC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951139 70885 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 541 10 1 8 3.6 CCCCc1nc(C)c(CCC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
10004112 25528 None 0 Rabbit Functional pIC50 = 8.3 8.3 93 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL135089 25528 None 0 Rabbit Functional pIC50 = 8.3 8.3 93 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10344052 116605 None 0 Rabbit Functional pIC50 = 8.3 8.3 107 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 456 9 1 5 5.7 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336738 116605 None 0 Rabbit Functional pIC50 = 8.3 8.3 107 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 456 9 1 5 5.7 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
142534191 166781 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 559 9 1 8 4.2 CCCCc1nc(C)c(CC(=S)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4284022 166781 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 559 9 1 8 4.2 CCCCc1nc(C)c(CC(=S)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14956758 106529 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 9 1 9 4.1 CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314042 106529 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 9 1 9 4.1 CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956769 107114 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 499 9 1 7 5.3 CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL316052 107114 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 499 9 1 7 5.3 CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956762 98828 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 519 8 1 7 5.6 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL278741 98828 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 519 8 1 7 5.6 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
54479908 70887 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 525 10 1 7 4.3 CCCCc1nc(C)c(CCC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951140 70887 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 525 10 1 7 4.3 CCCCc1nc(C)c(CCC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14956759 206100 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 495 9 2 8 4.0 CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85704 206100 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 495 9 2 8 4.0 CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956800 206148 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86143 206148 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1610 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
3941 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
3961 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
590 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
CHEMBL191 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
DB00678 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
14956805 206342 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 515 10 1 8 5.0 CCCCc1nn(COc2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87354 206342 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 515 10 1 8 5.0 CCCCc1nn(COc2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
9893748 182522 None 0 Bovine Functional pIC50 = 6.3 6.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 549 9 2 9 4.5 CCCCc1nc2ccc(C3CC(C(=O)O)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL47872 182522 None 0 Bovine Functional pIC50 = 6.3 6.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 549 9 2 9 4.5 CCCCc1nc2ccc(C3CC(C(=O)O)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
742856 53767 None 21 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 279 4 1 2 4.3 O=C(CNc1cccc(Cl)c1)c1ccc(Cl)cc1 nan
CHEMBL1603871 53767 None 21 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 279 4 1 2 4.3 O=C(CNc1cccc(Cl)c1)c1ccc(Cl)cc1 nan
14956789 206437 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 489 10 1 9 3.7 CCCCc1nn(C(C(=O)OC)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL88002 206437 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 489 10 1 9 3.7 CCCCc1nn(C(C(=O)OC)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
2811329 28650 None 5 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 279 3 2 4 3.0 Cc1ccc(NNC(=O)c2c(C)noc2C)cc1Cl nan
CHEMBL1377329 28650 None 5 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 279 3 2 4 3.0 Cc1ccc(NNC(=O)c2c(C)noc2C)cc1Cl nan
4328866 19491 None 3 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 247 3 0 4 1.2 CC(C)OC(=O)CN1C(=O)C(=O)c2ccccc21 nan
CHEMBL1299266 19491 None 3 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 247 3 0 4 1.2 CC(C)OC(=O)CN1C(=O)C(=O)c2ccccc21 nan
5770964 26453 None 2 Human Functional pIC50 = 5.3 5.3 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 444 9 2 6 2.6 COc1ccc(C(=O)/C=C/C(=O)N(CC(=O)NC2CCCCC2)CC2CCCO2)c(O)c1 nan
CHEMBL1359902 26453 None 2 Human Functional pIC50 = 5.3 5.3 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 444 9 2 6 2.6 COc1ccc(C(=O)/C=C/C(=O)N(CC(=O)NC2CCCCC2)CC2CCCO2)c(O)c1 nan
2744279 26657 None 2 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 351 5 0 10 2.5 CCn1nc(C)cc1-c1nnc(Sc2ncc([N+](=O)[O-])s2)n1C nan
CHEMBL1361740 26657 None 2 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 351 5 0 10 2.5 CCn1nc(C)cc1-c1nnc(Sc2ncc([N+](=O)[O-])s2)n1C nan
4068403 20720 None 11 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 360 4 1 6 4.0 O=C(Nc1nc(-c2ccccn2)cs1)c1cc(Cl)ccc1[N+](=O)[O-] nan
CHEMBL1309127 20720 None 11 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 360 4 1 6 4.0 O=C(Nc1nc(-c2ccccn2)cs1)c1cc(Cl)ccc1[N+](=O)[O-] nan
1610 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a013
1610 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a014
3941 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a013
3941 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a014
3961 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a013
3961 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a014
590 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a013
590 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a014
CHEMBL191 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a013
CHEMBL191 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a014
DB00678 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a013
DB00678 2345 None 95 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a014
788411 27368 None 13 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 4 1 2 4.3 Cc1ccc(C(=O)CNc2ccc(C)c(Cl)c2)cc1 nan
CHEMBL1367827 27368 None 13 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 4 1 2 4.3 Cc1ccc(C(=O)CNc2ccc(C)c(Cl)c2)cc1 nan
14971674 207298 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL93289 207298 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
15233933 101163 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL295532 101163 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
14971693 112909 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 560 9 1 7 6.5 CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL331063 112909 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 560 9 1 7 6.5 CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
18655851 101299 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 623 9 1 8 6.7 CCCCc1nc2ccc([C@]3(c4ccccc4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL296519 101299 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 623 9 1 8 6.7 CCCCc1nc2ccc([C@]3(c4ccccc4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
100520 32723 None 6 Human Functional pIC50 = 5.3 5.3 -4 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 240 3 0 7 2.0 O=[N+]([O-])c1cnc(Sc2ccncn2)s1 nan
CHEMBL1413680 32723 None 6 Human Functional pIC50 = 5.3 5.3 -4 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 240 3 0 7 2.0 O=[N+]([O-])c1cnc(Sc2ccncn2)s1 nan
788410 21165 None 15 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 4 1 2 3.9 Cc1ccc(NCC(=O)c2ccccc2)cc1Cl nan
CHEMBL1312651 21165 None 15 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 4 1 2 3.9 Cc1ccc(NCC(=O)c2ccccc2)cc1Cl nan
44292072 101298 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 618 9 1 9 4.7 CCCCc1nc2ccc([C@]3(C(=O)N(C)C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL296518 101298 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 618 9 1 9 4.7 CCCCc1nc2ccc([C@]3(C(=O)N(C)C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
14956773 206093 None 0 Rabbit Functional pIC50 = 6.2 6.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 504 9 2 6 5.0 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00069a015
CHEMBL85659 206093 None 0 Rabbit Functional pIC50 = 6.2 6.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 504 9 2 6 5.0 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00069a015
44292162 172289 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 9 1 8 6.0 CCCCc1nc2ccc([C@@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL44749 172289 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 9 1 8 6.0 CCCCc1nc2ccc([C@@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
16446380 31620 None 9 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 447 7 1 7 3.4 COc1ccc(OC)c(NC(=O)c2nc(S(=O)(=O)Cc3ccccc3)ncc2Cl)c1 nan
CHEMBL1404578 31620 None 9 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 447 7 1 7 3.4 COc1ccc(OC)c(NC(=O)c2nc(S(=O)(=O)Cc3ccccc3)ncc2Cl)c1 nan
718402 33886 None 15 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 5 0 6 2.6 COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cccnc1 nan
CHEMBL1423567 33886 None 15 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 5 0 6 2.6 COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cccnc1 nan
16437205 32001 None 9 Human Functional pIC50 = 5.2 5.2 -5 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 486 6 1 7 2.7 CCC1CCCCN1S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 nan
CHEMBL1407961 32001 None 9 Human Functional pIC50 = 5.2 5.2 -5 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 486 6 1 7 2.7 CCC1CCCCN1S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 nan
6873485 107576 None 8 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 410 7 1 5 4.9 CCCOc1cccc(-c2cc(C(=O)N/N=C/c3ccccn3)c3ccccc3n2)c1 nan
CHEMBL3189289 107576 None 8 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 410 7 1 5 4.9 CCCOc1cccc(-c2cc(C(=O)N/N=C/c3ccccn3)c3ccccc3n2)c1 nan
9569064 72248 None 2 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 363 6 1 4 4.0 C/C(=N\NC(=O)c1ccccc1OCc1ccc(F)cc1)c1ccccn1 nan
CHEMBL1981898 72248 None 2 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 363 6 1 4 4.0 C/C(=N\NC(=O)c1ccccc1OCc1ccc(F)cc1)c1ccccn1 nan
1481 2064 None 116 Human Functional pIC50 = 8.2 8.2 -2 6
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
3749 2064 None 116 Human Functional pIC50 = 8.2 8.2 -2 6
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
589 2064 None 116 Human Functional pIC50 = 8.2 8.2 -2 6
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
6908 2064 None 116 Human Functional pIC50 = 8.2 8.2 -2 6
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
CHEMBL1513 2064 None 116 Human Functional pIC50 = 8.2 8.2 -2 6
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
DB01029 2064 None 116 Human Functional pIC50 = 8.2 8.2 -2 6
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
108185 1612 None 78 Rabbit Functional pIC50 = 8.2 8.2 -3 5
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00069a015
586 1612 None 78 Rabbit Functional pIC50 = 8.2 8.2 -3 5
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00069a015
CHEMBL907 1612 None 78 Rabbit Functional pIC50 = 8.2 8.2 -3 5
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00069a015
57393229 70892 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 555 9 1 7 5.5 CCCCc1nc(C)c(CC(=S)N2CCCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951145 70892 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 555 9 1 7 5.5 CCCCc1nc(C)c(CC(=S)N2CCCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14956740 205806 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL83248 205806 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971677 111509 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL327837 111509 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956775 203979 None 0 Rabbit Functional pIC50 = 7.2 7.2 -1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 375 7 2 7 3.2 CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL69508 203979 None 0 Rabbit Functional pIC50 = 7.2 7.2 -1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 375 7 2 7 3.2 CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956808 206429 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 580 13 1 9 4.9 CCCCc1nn(CCCN(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87957 206429 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 580 13 1 9 4.9 CCCCc1nn(CCCN(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
330973 49687 None 3 Human Functional pIC50 = 5.2 5.2 -16 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
CHEMBL1566610 49687 None 3 Human Functional pIC50 = 5.2 5.2 -16 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
2812572 25022 None 5 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 274 4 2 2 3.7 CCc1ccc(C(=O)NNc2ccc(Cl)cc2)cc1 nan
CHEMBL1346661 25022 None 5 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 274 4 2 2 3.7 CCc1ccc(C(=O)NNc2ccc(Cl)cc2)cc1 nan
890649 53628 None 14 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 342 3 0 6 3.6 O=S1(=O)C=C(Sc2nnc(-c3ccccc3)o2)c2ccccc21 nan
CHEMBL1602759 53628 None 14 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 342 3 0 6 3.6 O=S1(=O)C=C(Sc2nnc(-c3ccccc3)o2)c2ccccc21 nan
44292456 101160 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 658 9 1 9 5.6 CCCCc1nc2ccc(C3(C(=O)N4CCCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL295514 101160 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 658 9 1 9 5.6 CCCCc1nc2ccc(C3(C(=O)N4CCCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
1610 2345 None 95 Rabbit Functional pIC50 = 7.2 7.2 -19 11
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2011.12.116
3941 2345 None 95 Rabbit Functional pIC50 = 7.2 7.2 -19 11
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2011.12.116
3961 2345 None 95 Rabbit Functional pIC50 = 7.2 7.2 -19 11
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2011.12.116
590 2345 None 95 Rabbit Functional pIC50 = 7.2 7.2 -19 11
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2011.12.116
CHEMBL191 2345 None 95 Rabbit Functional pIC50 = 7.2 7.2 -19 11
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2011.12.116
DB00678 2345 None 95 Rabbit Functional pIC50 = 7.2 7.2 -19 11
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2011.12.116
16436607 24063 None 10 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 486 6 1 7 2.6 CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCC(C)CC3)cc2)n1 nan
CHEMBL1338304 24063 None 10 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 486 6 1 7 2.6 CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCC(C)CC3)cc2)n1 nan
9619214 108075 None 6 Human Functional pIC50 = 5.2 5.2 -2 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 351 5 1 8 2.9 Cc1cc(N/N=C/c2ccccc2[N+](=O)[O-])nc(-n2nc(C)cc2C)n1 nan
CHEMBL3195226 108075 None 6 Human Functional pIC50 = 5.2 5.2 -2 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 351 5 1 8 2.9 Cc1cc(N/N=C/c2ccccc2[N+](=O)[O-])nc(-n2nc(C)cc2C)n1 nan
11744592 115501 None 0 Rabbit Functional pIC50 = 6.2 6.2 33 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 452 6 0 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 10.1021/jm00078a013
CHEMBL335228 115501 None 0 Rabbit Functional pIC50 = 6.2 6.2 33 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 452 6 0 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 10.1021/jm00078a013
6091989 49850 None 8 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 337 5 1 5 4.1 COc1cc(/C=C/c2ccc3cccc(O)c3n2)cc(OC)c1OC nan
CHEMBL1567899 49850 None 8 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 337 5 1 5 4.1 COc1cc(/C=C/c2ccc3cccc(O)c3n2)cc(OC)c1OC nan
44292070 171852 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 589 8 1 8 6.4 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL44690 171852 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 589 8 1 8 6.4 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
44292342 177257 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.3 CCCCc1nc2ccc([C@@H]3C[C@@]4(C)CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL46361 177257 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.3 CCCCc1nc2ccc([C@@H]3C[C@@]4(C)CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
6883924 71689 None 8 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 315 3 1 4 3.7 O=C(N/N=C/c1ccccn1)c1sc2ccccc2c1Cl nan
CHEMBL1964873 71689 None 8 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 315 3 1 4 3.7 O=C(N/N=C/c1ccccn1)c1sc2ccccc2c1Cl nan
10366811 24824 None 0 Rabbit Functional pIC50 = 7.2 7.2 31 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 10.1021/jm00078a014
CHEMBL134491 24824 None 0 Rabbit Functional pIC50 = 7.2 7.2 31 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 10.1021/jm00078a014
3117 207839 None 103 Human Functional pIC50 = 5.2 5.2 -9 24
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 296 4 0 4 3.6 CCN(CC)C(=S)SSC(=S)N(CC)CC nan
CHEMBL964 207839 None 103 Human Functional pIC50 = 5.2 5.2 -9 24
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 296 4 0 4 3.6 CCN(CC)C(=S)SSC(=S)N(CC)CC nan
780062 28945 None 7 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 276 3 2 4 3.4 Cc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1 nan
CHEMBL1380035 28945 None 7 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 276 3 2 4 3.4 Cc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1 nan
10048602 26048 None 0 Rabbit Functional pIC50 = 6.2 6.2 37 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 4 0 5 4.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N 10.1021/jm00078a013
CHEMBL135522 26048 None 0 Rabbit Functional pIC50 = 6.2 6.2 37 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 4 0 5 4.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N 10.1021/jm00078a013
9556585 154910 None 8 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 3 1 3 2.6 O=C(N/N=C/c1ccccn1)c1ccc(Br)cc1 nan
CHEMBL400912 154910 None 8 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 3 1 3 2.6 O=C(N/N=C/c1ccccn1)c1ccc(Br)cc1 nan
14956800 206148 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86143 206148 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956810 206157 None 0 Rabbit Functional pIC50 = 6.2 6.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 566 10 1 8 5.9 CCCCc1nn(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86232 206157 None 0 Rabbit Functional pIC50 = 6.2 6.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 566 10 1 8 5.9 CCCCc1nn(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
135449568 41660 None 3 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 286 4 2 7 2.5 COCc1cc(O)nc(Nc2nc3ccc(C)cc3o2)n1 nan
CHEMBL1492017 41660 None 3 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 286 4 2 7 2.5 COCc1cc(O)nc(Nc2nc3ccc(C)cc3o2)n1 nan
44292428 101092 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 644 9 1 9 5.3 CCCCc1nc2ccc(C3(C(=O)N4CCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL294992 101092 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 644 9 1 9 5.3 CCCCc1nc2ccc(C3(C(=O)N4CCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
44291956 171272 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 619 10 1 10 5.3 CCCCc1nc2ccc([C@H]3ON4CCCC4C3C(=O)OCC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL44605 171272 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 619 10 1 10 5.3 CCCCc1nc2ccc([C@H]3ON4CCCC4C3C(=O)OCC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
14956746 206192 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86440 206192 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
379338 16887 None 26 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 2 0 4 3.4 COc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 nan
CHEMBL125044 16887 None 26 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 2 0 4 3.4 COc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 nan
14956807 106122 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 566 12 1 9 4.9 CCCCc1nn(CCCOC(=O)N(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313435 106122 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 566 12 1 9 4.9 CCCCc1nn(CCCOC(=O)N(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956755 106147 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 469 8 1 7 4.4 CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313579 106147 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 469 8 1 7 4.4 CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10202093 206433 None 0 Rabbit Functional pIC50 = 8.1 8.1 2 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 417 8 1 7 3.9 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87985 206433 None 0 Rabbit Functional pIC50 = 8.1 8.1 2 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 417 8 1 7 3.9 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
145987183 167230 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 597 9 1 7 6.1 CCCCc1nc(C)c(CC(=S)N2CC[C@@H]3CCCC[C@H]32)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4292297 167230 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 597 9 1 7 6.1 CCCCc1nc(C)c(CC(=S)N2CC[C@@H]3CCCC[C@H]32)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
44291955 96624 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 589 8 1 8 6.4 CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL263471 96624 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 589 8 1 8 6.4 CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
18942289 101328 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 595 9 1 8 6.8 CCCCc1nc2ccc(C3CC(c4ccc(C)cc4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL296719 101328 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 595 9 1 8 6.8 CCCCc1nc2ccc(C3CC(c4ccc(C)cc4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
10003482 165741 None 0 Rabbit Functional pIC50 = 7.2 7.2 158 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 442 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL424643 165741 None 0 Rabbit Functional pIC50 = 7.2 7.2 158 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 442 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
14956776 105966 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 389 7 1 7 2.8 CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313017 105966 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 389 7 1 7 2.8 CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956790 171348 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 475 10 2 8 3.6 CCCCc1nn(C(C(=O)O)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL446152 171348 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 475 10 2 8 3.6 CCCCc1nn(C(C(=O)O)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
851388 55224 None 12 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 229 4 1 2 3.1 O=C(CNc1ccc(F)cc1)c1ccccc1 nan
CHEMBL1328306 55224 None 12 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 229 4 1 2 3.1 O=C(CNc1ccc(F)cc1)c1ccccc1 nan
CHEMBL1617841 55224 None 12 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 229 4 1 2 3.1 O=C(CNc1ccc(F)cc1)c1ccccc1 nan
1728272 44833 None 12 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 5 3 4 1.5 CCCOc1ccc(C(=O)NNC(=S)NC(=O)CC)cc1 nan
CHEMBL1522211 44833 None 12 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 5 3 4 1.5 CCCOc1ccc(C(=O)NNC(=S)NC(=O)CC)cc1 nan
135411933 41215 None 21 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 1 1 2 3.5 O=C1Nc2ccccc2C1=Nc1ccc(Br)cc1 nan
CHEMBL1488802 41215 None 21 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 1 1 2 3.5 O=C1Nc2ccccc2C1=Nc1ccc(Br)cc1 nan
2796987 23371 None 5 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 5 2 3 2.7 NC(=O)c1ccccc1NCC(=O)c1ccc(Cl)cc1 nan
CHEMBL1332717 23371 None 5 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 5 2 3 2.7 NC(=O)c1ccccc1NCC(=O)c1ccc(Cl)cc1 nan
379337 164205 None 27 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 258 1 0 3 3.4 O=C1c2ccccc2-c2nnc(-c3ccccc3)cc21 nan
CHEMBL421088 164205 None 27 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 258 1 0 3 3.4 O=C1c2ccccc2-c2nnc(-c3ccccc3)cc21 nan
788612 52324 None 9 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 4 1 2 4.1 Cc1ccc(C(=O)CNc2ccc(Br)cc2)cc1 nan
CHEMBL1589540 52324 None 9 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 4 1 2 4.1 Cc1ccc(C(=O)CNc2ccc(Br)cc2)cc1 nan
583493 42732 None 11 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 255 5 2 3 2.7 O=C(CNc1ccccc1C(=O)O)c1ccccc1 nan
CHEMBL1501792 42732 None 11 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 255 5 2 3 2.7 O=C(CNc1ccccc1C(=O)O)c1ccccc1 nan
1593681 30363 None 8 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 423 9 2 8 1.1 O=C(CNC(=O)c1ccco1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1391919 30363 None 8 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 423 9 2 8 1.1 O=C(CNC(=O)c1ccco1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
10258828 14657 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 498 9 1 7 5.0 CCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120549 14657 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 498 9 1 7 5.0 CCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971696 113426 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 572 9 1 7 6.7 CCOC(=O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl 10.1021/jm00075a014
CHEMBL331886 113426 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 572 9 1 7 6.7 CCOC(=O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl 10.1021/jm00075a014
14956782 206403 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 457 8 1 7 3.8 CCCCc1nn(CC(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87780 206403 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 457 8 1 7 3.8 CCCCc1nn(CC(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44341650 169885 None 0 Human Functional pIC50 = 5.1 5.1 -2 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 406 7 2 3 4.8 CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL444060 169885 None 0 Human Functional pIC50 = 5.1 5.1 -2 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 406 7 2 3 4.8 CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
135400371 53298 None 20 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 314 1 1 2 3.8 Cc1ccc(N=C2C(=O)Nc3ccc(Br)cc32)cc1 nan
CHEMBL1599499 53298 None 20 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 314 1 1 2 3.8 Cc1ccc(N=C2C(=O)Nc3ccc(Br)cc32)cc1 nan
135403068 23501 None 15 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 358 3 1 3 4.2 CCOc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 nan
CHEMBL1333730 23501 None 15 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 358 3 1 3 4.2 CCOc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 nan
6884203 108242 None 10 Human Functional pIC50 = 5.1 5.1 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 352 4 1 4 4.1 O=C(N/N=C/c1ccccn1)c1cc(-c2ccccc2)nc2ccccc12 nan
CHEMBL3197021 108242 None 10 Human Functional pIC50 = 5.1 5.1 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 352 4 1 4 4.1 O=C(N/N=C/c1ccccn1)c1cc(-c2ccccc2)nc2ccccc12 nan
2989697 48746 None 17 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 377 5 1 6 2.4 CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(OC(F)F)cc2)n1 nan
CHEMBL1558462 48746 None 17 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 377 5 1 6 2.4 CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(OC(F)F)cc2)n1 nan
10435200 23861 None 0 Rabbit Functional pIC50 = 6.1 6.1 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 478 5 1 7 4.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1-c1nn[nH]n1 10.1021/jm00078a013
CHEMBL133654 23861 None 0 Rabbit Functional pIC50 = 6.1 6.1 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 478 5 1 7 4.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1-c1nn[nH]n1 10.1021/jm00078a013
5953874 41100 None 5 Human Functional pIC50 = 5.1 5.1 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 2 1 6 2.8 N=C1S/C(=C\c2ccco2)C(=O)N1c1nccs1 nan
CHEMBL1488024 41100 None 5 Human Functional pIC50 = 5.1 5.1 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 2 1 6 2.8 N=C1S/C(=C\c2ccco2)C(=O)N1c1nccs1 nan
9675542 107807 None 5 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 3 1 3 2.8 Cc1cccc(/C=N/NC(=O)c2cccc(Cl)c2)n1 nan
CHEMBL3191999 107807 None 5 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 3 1 3 2.8 Cc1cccc(/C=N/NC(=O)c2cccc(Cl)c2)n1 nan
44292215 175438 None 0 Bovine Functional pIC50 = 7.1 7.1 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 605 9 1 10 4.8 CCCCc1nc2ccc([C@]3(C(=O)OC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL45766 175438 None 0 Bovine Functional pIC50 = 7.1 7.1 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 605 9 1 10 4.8 CCCCc1nc2ccc([C@]3(C(=O)OC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
14956774 206236 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 452 8 1 8 3.7 CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86741 206236 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 452 8 1 8 3.7 CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
6873171 108722 None 6 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 283 2 1 3 1.9 S=C(N/N=C/c1ccc(Cl)cc1)N1CCOCC1 nan
CHEMBL3208447 108722 None 6 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 283 2 1 3 1.9 S=C(N/N=C/c1ccc(Cl)cc1)N1CCOCC1 nan
14971678 14543 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120290 14543 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10365283 25851 None 0 Rabbit Functional pIC50 = 8.1 8.1 416 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 428 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135345 25851 None 0 Rabbit Functional pIC50 = 8.1 8.1 416 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 428 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10223724 205755 None 0 Rabbit Functional pIC50 = 8.1 8.1 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 417 9 1 7 3.7 CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL82797 205755 None 0 Rabbit Functional pIC50 = 8.1 8.1 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 417 9 1 7 3.7 CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10479472 115223 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 462 6 1 7 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
CHEMBL334660 115223 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 462 6 1 7 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
10344235 206158 None 0 Rabbit Functional pIC50 = 8.1 8.1 -1 3
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 460 5 1 7 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 10.1021/jm0603163
CHEMBL86247 206158 None 0 Rabbit Functional pIC50 = 8.1 8.1 -1 3
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 460 5 1 7 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 10.1021/jm0603163
10322504 26381 None 0 Rabbit Functional pIC50 = 7.1 7.1 19 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 9 1 5 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135929 26381 None 0 Rabbit Functional pIC50 = 7.1 7.1 19 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 9 1 5 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
14956747 205972 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL84630 205972 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971673 112358 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 10 1 7 5.8 CCCCc1nn(-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL329466 112358 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 10 1 7 5.8 CCCCc1nn(-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
5339648 72950 None 13 Human Functional pIC50 = 5.1 5.1 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 270 4 1 5 1.8 O=C(N/N=C/c1ccccn1)c1cccc([N+](=O)[O-])c1 nan
CHEMBL2005961 72950 None 13 Human Functional pIC50 = 5.1 5.1 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 270 4 1 5 1.8 O=C(N/N=C/c1ccccn1)c1cccc([N+](=O)[O-])c1 nan
10322995 115261 None 0 Rabbit Functional pIC50 = 7.1 7.1 134 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 482 9 1 5 6.1 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C 10.1021/jm00078a014
CHEMBL334832 115261 None 0 Rabbit Functional pIC50 = 7.1 7.1 134 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 482 9 1 5 6.1 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C 10.1021/jm00078a014
10026268 116928 None 0 Rabbit Functional pIC50 = 7.1 7.1 173 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 440 6 1 5 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 10.1021/jm00078a013
CHEMBL338505 116928 None 0 Rabbit Functional pIC50 = 7.1 7.1 173 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 440 6 1 5 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 10.1021/jm00078a013
854200 36030 None 9 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 239 4 1 2 3.6 Cc1ccc(C(=O)CNc2ccccc2C)cc1 nan
CHEMBL1443417 36030 None 9 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 239 4 1 2 3.6 Cc1ccc(C(=O)CNc2ccccc2C)cc1 nan
973504 95220 None 9 Human Functional pIC50 = 5.1 5.1 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 343 4 1 5 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)c([N+](=O)[O-])c1 nan
CHEMBL256042 95220 None 9 Human Functional pIC50 = 5.1 5.1 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 343 4 1 5 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)c([N+](=O)[O-])c1 nan
44292180 180946 None 0 Bovine Functional pIC50 = 7.1 7.1 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 9 1 8 6.0 CCCCc1nc2ccc([C@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL47583 180946 None 0 Bovine Functional pIC50 = 7.1 7.1 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 9 1 8 6.0 CCCCc1nc2ccc([C@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
200953 45837 None 8 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 196 1 0 2 2.5 O=C(C#Cc1ccccc1)c1ccco1 nan
CHEMBL1531308 45837 None 8 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 196 1 0 2 2.5 O=C(C#Cc1ccccc1)c1ccco1 nan
2812483 43582 None 5 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 245 3 2 4 2.4 Cc1cc(C(=O)NNc2ccc(C)c(C)c2)no1 nan
CHEMBL1509162 43582 None 5 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 245 3 2 4 2.4 Cc1cc(C(=O)NNc2ccc(C)c(C)c2)no1 nan
6873172 109080 None 11 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 263 2 1 3 1.5 Cc1ccc(/C=N/NC(=S)N2CCOCC2)cc1 nan
CHEMBL3213140 109080 None 11 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 263 2 1 3 1.5 Cc1ccc(/C=N/NC(=S)N2CCOCC2)cc1 nan
10437543 26265 None 0 Rabbit Functional pIC50 = 6.1 6.1 7 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 550 7 2 5 6.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
CHEMBL135819 26265 None 0 Rabbit Functional pIC50 = 6.1 6.1 7 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 550 7 2 5 6.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
878879 38182 None 10 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 4 1 2 4.1 Cc1ccccc1NCC(=O)c1ccc(Br)cc1 nan
CHEMBL1461745 38182 None 10 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 4 1 2 4.1 Cc1ccccc1NCC(=O)c1ccc(Br)cc1 nan
44341785 10145 None 0 Human Functional pIC50 = 5.1 5.1 -3 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 438 6 1 3 5.3 O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL115771 10145 None 0 Human Functional pIC50 = 5.1 5.1 -3 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 438 6 1 3 5.3 O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 10.1021/acsmedchemlett.1c00240
6792924 107986 None 10 Human Functional pIC50 = 5.1 5.1 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 3 1 3 2.5 O=C(N/N=C/c1ccccn1)c1ccc(Cl)cc1 nan
CHEMBL3194040 107986 None 10 Human Functional pIC50 = 5.1 5.1 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 3 1 3 2.5 O=C(N/N=C/c1ccccn1)c1ccc(Cl)cc1 nan
1511959 21123 None 10 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 359 3 0 8 2.0 CC(=O)C1=C(c2cccc([N+](=O)[O-])c2)N(C(C)=O)n2c(C)nnc2S1 nan
CHEMBL1312377 21123 None 10 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 359 3 0 8 2.0 CC(=O)C1=C(c2cccc([N+](=O)[O-])c2)N(C(C)=O)n2c(C)nnc2S1 nan
10050755 115509 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 478 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(F)ccc2F)cc1 10.1021/jm00078a014
CHEMBL335276 115509 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 478 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(F)ccc2F)cc1 10.1021/jm00078a014
54508770 70871 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 472 10 2 7 3.8 CCCCc1nc(C)c(CCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951125 70871 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 472 10 2 7 3.8 CCCCc1nc(C)c(CCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971682 111485 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 551 11 1 9 5.7 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL327718 111485 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 551 11 1 9 5.7 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956771 206351 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 482 8 1 9 3.8 CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87392 206351 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 482 8 1 9 3.8 CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
57393228 70888 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 539 10 1 7 4.7 CCCCc1nc(C)c(CCC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951141 70888 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 539 10 1 7 4.7 CCCCc1nc(C)c(CCC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971676 163372 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL419321 163372 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956776 105966 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 389 7 1 7 2.8 CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313017 105966 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 389 7 1 7 2.8 CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
824082 26479 None 10 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 326 5 0 5 2.6 Cc1ccc(OCCN2C(=O)c3ccccc3C2=O)c([N+](=O)[O-])c1 nan
CHEMBL1360149 26479 None 10 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 326 5 0 5 2.6 Cc1ccc(OCCN2C(=O)c3ccccc3C2=O)c([N+](=O)[O-])c1 nan
2564786 44698 None 7 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 225 4 1 2 3.3 Cc1ccc(C(=O)CNc2ccccc2)cc1 nan
CHEMBL1521054 44698 None 7 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 225 4 1 2 3.3 Cc1ccc(C(=O)CNc2ccccc2)cc1 nan
11754335 25301 None 0 Rabbit Functional pIC50 = 7.0 7.0 186 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 467 5 2 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 10.1021/jm00078a013
CHEMBL134901 25301 None 0 Rabbit Functional pIC50 = 7.0 7.0 186 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 467 5 2 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 10.1021/jm00078a013
1625575 54283 None 10 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 297 5 1 5 1.5 CCOC(=O)/C=C/S(=O)(=O)c1ccc(NC(C)=O)cc1 nan
CHEMBL1608078 54283 None 10 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 297 5 1 5 1.5 CCOC(=O)/C=C/S(=O)(=O)c1ccc(NC(C)=O)cc1 nan
5680364 54902 None 5 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 272 2 1 4 0.9 CCOC(=O)C1=C2NC(=O)c3ccccc3N2C(=O)C1 nan
CHEMBL1613515 54902 None 5 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 272 2 1 4 0.9 CCOC(=O)C1=C2NC(=O)c3ccccc3N2C(=O)C1 nan
2411934 55448 None 2 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 451 10 2 6 4.3 CCOC(=O)c1c(-c2ccc(-c3ccccc3)cc2)csc1NC(=O)CNCCN(C)C nan
CHEMBL1409219 55448 None 2 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 451 10 2 6 4.3 CCOC(=O)c1c(-c2ccc(-c3ccccc3)cc2)csc1NC(=O)CNCCN(C)C nan
CHEMBL1619798 55448 None 2 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 451 10 2 6 4.3 CCOC(=O)c1c(-c2ccc(-c3ccccc3)cc2)csc1NC(=O)CNCCN(C)C nan
2170433 46189 None 10 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 390 8 1 6 2.3 O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1534477 46189 None 10 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 390 8 1 6 2.3 O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
9590742 107571 None 3 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 3 1 3 2.9 C/C(=N\NC(=O)c1ccccc1Cl)c1ccccn1 nan
CHEMBL3189245 107571 None 3 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 3 1 3 2.9 C/C(=N\NC(=O)c1ccccc1Cl)c1ccccn1 nan
10434876 116616 None 0 Rabbit Functional pIC50 = 7.0 7.0 7 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 10 1 5 6.1 CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336808 116616 None 0 Rabbit Functional pIC50 = 7.0 7.0 7 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 10 1 5 6.1 CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
2474590 43164 None 4 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 291 2 1 4 3.2 O=C(Nc1nc2c(F)cc(F)cc2s1)c1ccccn1 nan
CHEMBL1505604 43164 None 4 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 291 2 1 4 3.2 O=C(Nc1nc2c(F)cc(F)cc2s1)c1ccccn1 nan
9667523 108848 None 8 Human Functional pIC50 = 5.0 5.0 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 328 6 1 6 2.3 C/C(=N\NC(=O)C(C)Oc1ccc([N+](=O)[O-])cc1)c1ccccn1 nan
CHEMBL3210072 108848 None 8 Human Functional pIC50 = 5.0 5.0 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 328 6 1 6 2.3 C/C(=N\NC(=O)C(C)Oc1ccc([N+](=O)[O-])cc1)c1ccccn1 nan
14956770 206255 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 480 7 1 9 3.7 O=c1n(-c2ccccc2[N+](=O)[O-])nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86853 206255 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 480 7 1 9 3.7 O=c1n(-c2ccccc2[N+](=O)[O-])nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956785 206390 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 460 9 2 8 2.6 CCCCc1nn(C(C)C(=O)NC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87682 206390 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 460 9 2 8 2.6 CCCCc1nn(C(C)C(=O)NC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1487013 51962 None 16 Human Functional pIC50 = 5.0 5.0 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 317 3 1 6 1.4 CNC(=O)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 nan
CHEMBL1586425 51962 None 16 Human Functional pIC50 = 5.0 5.0 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 317 3 1 6 1.4 CNC(=O)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 nan
5337284 45704 None 6 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 342 5 1 3 4.5 Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3ccncc3)cc2)c1 nan
CHEMBL1530173 45704 None 6 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 342 5 1 3 4.5 Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3ccncc3)cc2)c1 nan
991372 53848 None 33 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 382 1 2 5 4.5 CC1(C)CC(=O)C2=C(C1)OC1=C(C(=O)CC(C)(C)C1)C2c1ccc(O)cc1O nan
CHEMBL1604546 53848 None 33 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 382 1 2 5 4.5 CC1(C)CC(=O)C2=C(C1)OC1=C(C(=O)CC(C)(C)C1)C2c1ccc(O)cc1O nan
135472791 22333 None 7 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 2 1 4 5.0 Cc1ccc(C)c(N=Nc2ccc(O)c3ncccc23)c1 nan
CHEMBL1324011 22333 None 7 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 2 1 4 5.0 Cc1ccc(C)c(N=Nc2ccc(O)c3ncccc23)c1 nan
788618 20002 None 11 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 253 4 1 2 3.9 Cc1ccc(C(=O)CNc2cc(C)ccc2C)cc1 nan
CHEMBL1303334 20002 None 11 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 253 4 1 2 3.9 Cc1ccc(C(=O)CNc2cc(C)ccc2C)cc1 nan
788408 43543 None 13 Human Functional pIC50 = 5 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 4 1 2 3.9 Cc1ccc(C(=O)CNc2cccc(Cl)c2)cc1 nan
CHEMBL1508797 43543 None 13 Human Functional pIC50 = 5 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 4 1 2 3.9 Cc1ccc(C(=O)CNc2cccc(Cl)c2)cc1 nan
6918269 98468 None 11 Human Functional pKd = 10.9 10.9 5 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL275875 98468 None 11 Human Functional pKd = 10.9 10.9 5 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL295959 98468 None 11 Human Functional pKd = 10.9 10.9 5 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
11527144 179103 None 0 Human Functional pKd = 10.9 10.9 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL297425 179103 None 0 Human Functional pKd = 10.9 10.9 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL47177 179103 None 0 Human Functional pKd = 10.9 10.9 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
133031 100857 None 21 Rabbit Functional pKd = 10.3 10.3 -1 3
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL293511 100857 None 21 Rabbit Functional pKd = 10.3 10.3 -1 3
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/j.bmc.2010.10.043
9887844 163198 None 4 Rabbit Functional pKd = 10.3 10.3 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 411 6 1 5 4.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/j.bmc.2010.10.043
CHEMBL418226 163198 None 4 Rabbit Functional pKd = 10.3 10.3 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 411 6 1 5 4.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/j.bmc.2010.10.043
9911332 44699 None 1 Rabbit Functional pKd = 10.2 10.2 - 0
Antagonism against Angiotensin II receptor, type 1 in rabbit aortaAntagonism against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 444 7 2 6 4.7 CCCn1nc(C(C)(C)C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9604383
CHEMBL152106 44699 None 1 Rabbit Functional pKd = 10.2 10.2 - 0
Antagonism against Angiotensin II receptor, type 1 in rabbit aortaAntagonism against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 444 7 2 6 4.7 CCCn1nc(C(C)(C)C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9604383
132387 162332 None 23 Rabbit Functional pKd = 10.1 10.1 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 414 8 2 6 4.0 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1016/j.bmc.2010.10.043
CHEMBL416477 162332 None 23 Rabbit Functional pKd = 10.1 10.1 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 414 8 2 6 4.0 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1016/j.bmc.2010.10.043
108185 1612 None 78 Rabbit Functional pKd = 10.1 10.1 -3 5
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1016/j.bmc.2010.10.043
586 1612 None 78 Rabbit Functional pKd = 10.1 10.1 -3 5
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1016/j.bmc.2010.10.043
CHEMBL907 1612 None 78 Rabbit Functional pKd = 10.1 10.1 -3 5
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1016/j.bmc.2010.10.043
9802561 161249 None 26 Rabbit Functional pKd = 10.0 10.0 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 426 6 1 6 4.6 CCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CCCC2 10.1016/j.bmc.2010.10.043
CHEMBL41194 161249 None 26 Rabbit Functional pKd = 10.0 10.0 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 426 6 1 6 4.6 CCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CCCC2 10.1016/j.bmc.2010.10.043
19890807 111532 None 0 Rabbit Functional pKd = 10 10.0 - 0
Antagonistic ability of angiotensin II to contract rabbit aortaAntagonistic ability of angiotensin II to contract rabbit aorta
ChEMBL 466 8 1 7 5.4 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(OC(C)C)ccc2n1 10.1021/jm00070a012
CHEMBL327932 111532 None 0 Rabbit Functional pKd = 10 10.0 - 0
Antagonistic ability of angiotensin II to contract rabbit aortaAntagonistic ability of angiotensin II to contract rabbit aorta
ChEMBL 466 8 1 7 5.4 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(OC(C)C)ccc2n1 10.1021/jm00070a012
15657904 187480 None 4 Rabbit Functional pKd = 9.9 9.9 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 415 8 2 7 3.4 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O 10.1016/j.bmc.2010.10.043
CHEMBL49410 187480 None 4 Rabbit Functional pKd = 9.9 9.9 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 415 8 2 7 3.4 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O 10.1016/j.bmc.2010.10.043
19017678 176151 None 0 Human Functional pKd = 9.3 9.3 - 0
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 474 11 2 8 4.3 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nnn(CC(C)C)c1C(=O)O 10.1016/j.bmc.2010.10.043
CHEMBL45927 176151 None 0 Human Functional pKd = 9.3 9.3 - 0
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 474 11 2 8 4.3 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nnn(CC(C)C)c1C(=O)O 10.1016/j.bmc.2010.10.043
9935096 207769 None 1 Human Functional pKd = 9.3 9.3 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 485 8 1 7 5.3 CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 10.1016/j.bmc.2010.10.043
CHEMBL9599 207769 None 1 Human Functional pKd = 9.3 9.3 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 485 8 1 7 5.3 CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 10.1016/j.bmc.2010.10.043
44373246 168265 None 0 Rabbit Functional pKd = 9.2 9.2 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 435 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 10.1016/j.bmc.2010.10.043
CHEMBL433895 168265 None 0 Rabbit Functional pKd = 9.2 9.2 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 435 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 10.1016/j.bmc.2010.10.043
CHEMBL2373017 210352 None 0 Rat Functional pKd = 9.1 9.1 - 0
pA2 value for Angiotensin II receptorpA2 value for Angiotensin II receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCSSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)O 10.1021/jm00169a019
9912059 185354 None 0 Rabbit Functional pKd = 9 9.0 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 459 7 1 6 4.5 CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL48602 185354 None 0 Rabbit Functional pKd = 9 9.0 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 459 7 1 6 4.5 CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
131654 206401 None 12 Rabbit Functional pKd = 8.9 8.9 1 2
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL87778 206401 None 12 Rabbit Functional pKd = 8.9 8.9 1 2
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
9801006 119727 None 0 Rabbit Functional pKd = 8.8 8.8 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 398 6 1 7 3.6 CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 10.1016/j.bmc.2010.10.043
CHEMBL347610 119727 None 0 Rabbit Functional pKd = 8.8 8.8 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 398 6 1 7 3.6 CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 10.1016/j.bmc.2010.10.043
178553 120242 None 14 Rabbit Functional pKd = 8.8 8.8 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 387 6 1 6 4.1 COc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C 10.1016/j.bmc.2010.10.043
CHEMBL352257 120242 None 14 Rabbit Functional pKd = 8.8 8.8 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 387 6 1 6 4.1 COc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C 10.1016/j.bmc.2010.10.043
70682146 76329 None 0 Rabbit Functional pKd = 8.8 8.8 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058860 76329 None 0 Rabbit Functional pKd = 8.8 8.8 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
46910493 76333 None 0 Rabbit Functional pKd = 8.7 8.7 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 615 12 2 8 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058864 76333 None 0 Rabbit Functional pKd = 8.7 8.7 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 615 12 2 8 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
9931685 206082 None 0 Human Functional pKd = 8.7 8.7 1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 415 10 1 6 4.9 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1016/j.bmc.2010.10.043
CHEMBL85595 206082 None 0 Human Functional pKd = 8.7 8.7 1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 415 10 1 6 4.9 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1016/j.bmc.2010.10.043
131857 204257 None 20 Rabbit Functional pKd = 8.7 8.7 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 383 5 1 4 5.0 Cc1ccnc2c1nc(C1CC1)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
CHEMBL71162 204257 None 20 Rabbit Functional pKd = 8.7 8.7 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 383 5 1 4 5.0 Cc1ccnc2c1nc(C1CC1)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
44438885 90952 None 0 Rabbit Functional pKd = 8 8.0 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 417 8 2 5 4.6 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL239378 90952 None 0 Rabbit Functional pKd = 8 8.0 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 417 8 2 5 4.6 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
2541 785 None 120 Rat Functional pKd = 8 8.0 - 10
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2007.11.008
587 785 None 120 Rat Functional pKd = 8 8.0 - 10
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2007.11.008
6907 785 None 120 Rat Functional pKd = 8 8.0 - 10
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2007.11.008
CHEMBL1016 785 None 120 Rat Functional pKd = 8 8.0 - 10
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2007.11.008
DB00796 785 None 120 Rat Functional pKd = 8 8.0 - 10
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2007.11.008
DB13919 785 None 120 Rat Functional pKd = 8 8.0 - 10
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2007.11.008
10094851 21295 None 0 Rat Functional pKd = 8 8.0 - 1
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 441 8 2 4 5.8 CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL131365 21295 None 0 Rat Functional pKd = 8 8.0 - 1
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 441 8 2 4 5.8 CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
1610 2345 None 95 Rat Functional pKd = 8 8.0 -9 11
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.056
3941 2345 None 95 Rat Functional pKd = 8 8.0 -9 11
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.056
3961 2345 None 95 Rat Functional pKd = 8 8.0 -9 11
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.056
590 2345 None 95 Rat Functional pKd = 8 8.0 -9 11
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.056
CHEMBL191 2345 None 95 Rat Functional pKd = 8 8.0 -9 11
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.056
DB00678 2345 None 95 Rat Functional pKd = 8 8.0 -9 11
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.056
24827770 95878 None 0 Rabbit Functional pKd = 8.0 8.0 - 1
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 425 7 1 7 3.9 CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL259114 95878 None 0 Rabbit Functional pKd = 8.0 8.0 - 1
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 425 7 1 7 3.9 CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
44438869 146333 None 0 Rabbit Functional pKd = 7 7.0 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 413 5 1 8 3.2 COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 10.1016/j.bmcl.2007.02.042
CHEMBL392118 146333 None 0 Rabbit Functional pKd = 7 7.0 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 413 5 1 8 3.2 COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 10.1016/j.bmcl.2007.02.042
44438900 147846 None 0 Rabbit Functional pKd = 7 7.0 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 403 7 2 5 4.2 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL393305 147846 None 0 Rabbit Functional pKd = 7 7.0 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 403 7 2 5 4.2 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
44570265 178407 None 0 Rat Functional pKd = 7 7.0 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 519 12 2 5 5.9 CCCCNS(=O)(=O)c1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL465929 178407 None 0 Rat Functional pKd = 7 7.0 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 519 12 2 5 5.9 CCCCNS(=O)(=O)c1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
19351553 118696 None 0 Rabbit Functional pKd = 7 7.0 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 389 10 4 6 3.1 CCCCCCC(C(=O)O)n1cnc(NC(=O)c2cccc(O)c2C(=O)O)c1 10.1016/j.bmc.2010.10.043
CHEMBL341716 118696 None 0 Rabbit Functional pKd = 7 7.0 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 389 10 4 6 3.1 CCCCCCC(C(=O)O)n1cnc(NC(=O)c2cccc(O)c2C(=O)O)c1 10.1016/j.bmc.2010.10.043
CHEMBL264230 210607 None 0 Rabbit Functional pKd = 7.0 7.0 - 0
Negative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aortaNegative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aorta
ChEMBL None None None CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)O)C(C)C)C(C)C 10.1021/jm9608669
CHEMBL384349 212321 None 0 Rabbit Functional pKd = 7.0 7.0 - 0
Negative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aortaNegative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aorta
ChEMBL None None None CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccc3ccccc3c2)C(=O)O)C(C)C)cc1 10.1021/jm9608669
1610 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
3941 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
3961 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
590 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
CHEMBL191 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
DB00678 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
44438865 93373 None 0 Rabbit Functional pKd = 7.9 7.9 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 441 7 1 8 3.8 CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL245644 93373 None 0 Rabbit Functional pKd = 7.9 7.9 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 441 7 1 8 3.8 CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
1610 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
3941 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
3961 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
590 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
CHEMBL191 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
DB00678 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
44570305 190316 None 0 Rat Functional pKd = 7.9 7.9 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 545 10 2 5 6.4 CCCCc1nc2cc(S(=O)(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL517626 190316 None 0 Rat Functional pKd = 7.9 7.9 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 545 10 2 5 6.4 CCCCc1nc2cc(S(=O)(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
1610 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
3941 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
3961 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
590 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
CHEMBL191 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
DB00678 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
44348352 16526 None 0 Rabbit Functional pKd = 7.9 7.9 1 2
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 459 8 1 6 4.5 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC 10.1016/j.bmc.2010.10.043
CHEMBL123713 16526 None 0 Rabbit Functional pKd = 7.9 7.9 1 2
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 459 8 1 6 4.5 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC 10.1016/j.bmc.2010.10.043
1610 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
3941 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
3961 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
590 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
CHEMBL191 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
DB00678 2345 None 95 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
44570215 183549 None 0 Rat Functional pKd = 6.9 6.9 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 477 9 2 5 4.7 CCCCc1nc2cc(S(=O)(=O)NC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL480018 183549 None 0 Rat Functional pKd = 6.9 6.9 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 477 9 2 5 4.7 CCCCc1nc2cc(S(=O)(=O)NC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
9906367 52147 None 0 Human Functional pKd = 6.9 6.9 - 0
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 349 4 1 5 3.1 C[C@H]1CN(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C[C@@H](C)O1 10.1016/j.bmc.2010.10.043
CHEMBL158794 52147 None 0 Human Functional pKd = 6.9 6.9 - 0
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 349 4 1 5 3.1 C[C@H]1CN(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C[C@@H](C)O1 10.1016/j.bmc.2010.10.043
44438902 169394 None 0 Rabbit Functional pKd = 5.9 5.9 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 375 5 2 5 3.6 Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL442251 169394 None 0 Rabbit Functional pKd = 5.9 5.9 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 375 5 2 5 3.6 Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
46910495 76330 None 0 Rabbit Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 585 11 2 7 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058861 76330 None 0 Rabbit Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 585 11 2 7 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
24828707 95935 None 0 Rabbit Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 425 7 1 7 3.9 CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL259353 95935 None 0 Rabbit Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 425 7 1 7 3.9 CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
44438870 92003 None 0 Rabbit Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 469 9 1 8 4.6 CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL241685 92003 None 0 Rabbit Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 469 9 1 8 4.6 CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
10250336 18884 None 0 Rat Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 399 7 2 4 5.4 CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL128318 18884 None 0 Rat Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 399 7 2 4 5.4 CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
53323218 60250 None 0 Guinea pig Functional pKd = 7.8 7.8 - 0
Antagonist activity at angiotensin AT1 receptor in guinea pig ileumAntagonist activity at angiotensin AT1 receptor in guinea pig ileum
ChEMBL 417 7 2 5 4.5 CCCc1nc2cc(C(=O)OC)[nH]c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1668010 60250 None 0 Guinea pig Functional pKd = 7.8 7.8 - 0
Antagonist activity at angiotensin AT1 receptor in guinea pig ileumAntagonist activity at angiotensin AT1 receptor in guinea pig ileum
ChEMBL 417 7 2 5 4.5 CCCc1nc2cc(C(=O)OC)[nH]c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1741079 60250 None 0 Guinea pig Functional pKd = 7.8 7.8 - 0
Antagonist activity at angiotensin AT1 receptor in guinea pig ileumAntagonist activity at angiotensin AT1 receptor in guinea pig ileum
ChEMBL 417 7 2 5 4.5 CCCc1nc2cc(C(=O)OC)[nH]c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
25110812 179037 None 0 Rat Functional pKd = 7.7 7.7 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 455 9 2 4 6.1 CCCCc1nc2cc(NC(=O)CC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL471334 179037 None 0 Rat Functional pKd = 7.7 7.7 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 455 9 2 4 6.1 CCCCc1nc2cc(NC(=O)CC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
1610 2345 None 95 Rabbit Functional pKd = 6.7 6.7 -19 11
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
3941 2345 None 95 Rabbit Functional pKd = 6.7 6.7 -19 11
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
3961 2345 None 95 Rabbit Functional pKd = 6.7 6.7 -19 11
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
590 2345 None 95 Rabbit Functional pKd = 6.7 6.7 -19 11
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
CHEMBL191 2345 None 95 Rabbit Functional pKd = 6.7 6.7 -19 11
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
DB00678 2345 None 95 Rabbit Functional pKd = 6.7 6.7 -19 11
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
44570214 183548 None 0 Rat Functional pKd = 6.7 6.7 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 463 8 2 5 4.4 CCCCc1nc2cc(S(N)(=O)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL480017 183548 None 0 Rat Functional pKd = 6.7 6.7 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 463 8 2 5 4.4 CCCCc1nc2cc(S(N)(=O)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
9932483 207841 None 0 Human Functional pKd = 8.7 8.7 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 431 10 1 7 4.1 CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 10.1016/j.bmc.2010.10.043
CHEMBL9642 207841 None 0 Human Functional pKd = 8.7 8.7 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 431 10 1 7 4.1 CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 10.1016/j.bmc.2010.10.043
9954408 207965 None 0 Human Functional pKd = 8.7 8.7 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 430 10 1 6 4.7 CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL9714 207965 None 0 Human Functional pKd = 8.7 8.7 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 430 10 1 6 4.7 CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
25112615 185889 None 0 Rat Functional pKd = 6.6 6.6 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 503 9 2 4 7.0 CCCCc1nc2cc(NC(=O)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL486847 185889 None 0 Rat Functional pKd = 6.6 6.6 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 503 9 2 4 7.0 CCCCc1nc2cc(NC(=O)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
44570306 178295 None 0 Rat Functional pKd = 6.6 6.6 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 464 8 2 5 5.0 CCCCc1nc2cc(S(=O)(=O)O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL465097 178295 None 0 Rat Functional pKd = 6.6 6.6 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 464 8 2 5 5.0 CCCCc1nc2cc(S(=O)(=O)O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
15224471 154831 None 0 Rabbit Functional pKd = 8.5 8.5 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 441 8 2 7 4.1 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL400424 154831 None 0 Rabbit Functional pKd = 8.5 8.5 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 441 8 2 7 4.1 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
2541 785 None 120 Rat Functional pKd = 8.5 8.5 - 10
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2008.10.056
587 785 None 120 Rat Functional pKd = 8.5 8.5 - 10
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2008.10.056
6907 785 None 120 Rat Functional pKd = 8.5 8.5 - 10
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2008.10.056
CHEMBL1016 785 None 120 Rat Functional pKd = 8.5 8.5 - 10
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2008.10.056
DB00796 785 None 120 Rat Functional pKd = 8.5 8.5 - 10
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2008.10.056
DB13919 785 None 120 Rat Functional pKd = 8.5 8.5 - 10
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2008.10.056
4110026 204933 None 1 Rat Functional pKd = 8.5 8.5 - 2
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 384 7 1 3 5.8 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL7632 204933 None 1 Rat Functional pKd = 8.5 8.5 - 2
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 384 7 1 3 5.8 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
57380647 70352 None 0 Rabbit Functional pKd = 8.5 8.5 - 2
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945010 70352 None 0 Rabbit Functional pKd = 8.5 8.5 - 2
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
9823146 19359 None 0 Human Functional pKd = 8.5 8.5 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 415 10 1 6 4.9 CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 10.1016/j.bmc.2010.10.043
CHEMBL12909 19359 None 0 Human Functional pKd = 8.5 8.5 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 415 10 1 6 4.9 CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 10.1016/j.bmc.2010.10.043
1610 2345 None 95 Human Functional pKd = 8.5 8.5 -9 11
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
3941 2345 None 95 Human Functional pKd = 8.5 8.5 -9 11
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
3961 2345 None 95 Human Functional pKd = 8.5 8.5 -9 11
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
590 2345 None 95 Human Functional pKd = 8.5 8.5 -9 11
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
CHEMBL191 2345 None 95 Human Functional pKd = 8.5 8.5 -9 11
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
DB00678 2345 None 95 Human Functional pKd = 8.5 8.5 -9 11
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
9801627 52060 None 17 Rabbit Functional pKd = 8.5 8.5 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 409 7 1 6 4.7 CCCCc1nc2cccnc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL158725 52060 None 17 Rabbit Functional pKd = 8.5 8.5 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 409 7 1 6 4.7 CCCCc1nc2cccnc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
17748251 93345 None 0 Rabbit Functional pKd = 8.4 8.4 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 455 8 1 8 4.2 CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL245444 93345 None 0 Rabbit Functional pKd = 8.4 8.4 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 455 8 1 8 4.2 CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
44570266 190813 None 0 Rat Functional pKd = 8.4 8.4 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 519 9 2 5 5.9 CCCCc1nc2cc(S(=O)(=O)NC(C)(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL518388 190813 None 0 Rat Functional pKd = 8.4 8.4 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 519 9 2 5 5.9 CCCCc1nc2cc(S(=O)(=O)NC(C)(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
9938452 117913 None 0 Rabbit Functional pKd = 8.4 8.4 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 591 13 2 6 8.1 CCCCCc1nc(SCc2ccc(-c3ccccc3C(=O)O)cc2)nn1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
CHEMBL340315 117913 None 0 Rabbit Functional pKd = 8.4 8.4 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 591 13 2 6 8.1 CCCCCc1nc(SCc2ccc(-c3ccccc3C(=O)O)cc2)nn1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
17748251 93345 None 0 Rabbit Functional pKd = 8.4 8.4 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 455 8 1 8 4.2 CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL245444 93345 None 0 Rabbit Functional pKd = 8.4 8.4 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 455 8 1 8 4.2 CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
44438868 92002 None 0 Rabbit Functional pKd = 7.5 7.5 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 427 6 1 8 3.4 CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL241684 92002 None 0 Rabbit Functional pKd = 7.5 7.5 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 427 6 1 8 3.4 CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
44438901 91985 None 0 Rabbit Functional pKd = 6.5 6.5 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 389 6 2 5 3.8 CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL241529 91985 None 0 Rabbit Functional pKd = 6.5 6.5 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 389 6 2 5 3.8 CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
25112616 185890 None 0 Rat Functional pKd = 6.5 6.5 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 537 9 2 4 7.7 CCCCc1nc2cc(NC(=O)c3ccccc3Cl)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL486848 185890 None 0 Rat Functional pKd = 6.5 6.5 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 537 9 2 4 7.7 CCCCc1nc2cc(NC(=O)c3ccccc3Cl)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL415157 213172 None 0 Rabbit Functional pKd = 7.4 7.4 - 0
Negative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aortaNegative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aorta
ChEMBL None None None CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)C(C)C)cc1 10.1021/jm9608669
1610 2345 None 95 Rat Functional pKd = 7.4 7.4 -9 11
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2007.11.008
3941 2345 None 95 Rat Functional pKd = 7.4 7.4 -9 11
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2007.11.008
3961 2345 None 95 Rat Functional pKd = 7.4 7.4 -9 11
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2007.11.008
590 2345 None 95 Rat Functional pKd = 7.4 7.4 -9 11
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2007.11.008
CHEMBL191 2345 None 95 Rat Functional pKd = 7.4 7.4 -9 11
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2007.11.008
DB00678 2345 None 95 Rat Functional pKd = 7.4 7.4 -9 11
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2007.11.008
25112614 191621 None 0 Rat Functional pKd = 6.4 6.4 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 483 11 2 4 6.9 CCCCC(=O)Nc1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL519564 191621 None 0 Rat Functional pKd = 6.4 6.4 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 483 11 2 4 6.9 CCCCC(=O)Nc1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
70686410 76328 None 0 Rabbit Functional pKd = 8.3 8.3 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 555 10 2 6 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058859 76328 None 0 Rabbit Functional pKd = 8.3 8.3 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 555 10 2 6 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
57380414 70528 None 0 Rabbit Functional pKd = 8.3 8.3 - 2
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947131 70528 None 0 Rabbit Functional pKd = 8.3 8.3 - 2
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
44339988 161005 None 0 Rabbit Functional pKd = 5.3 5.3 - 0
Negative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aortaNegative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aorta
ChEMBL 989 27 12 12 -1.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C 10.1021/jm9608669
CHEMBL411624 161005 None 0 Rabbit Functional pKd = 5.3 5.3 - 0
Negative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aortaNegative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aorta
ChEMBL 989 27 12 12 -1.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C 10.1021/jm9608669
132562 99681 None 6 Rabbit Functional pKd = 8.3 8.3 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 407 6 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1016/j.bmc.2010.10.043
CHEMBL284536 99681 None 6 Rabbit Functional pKd = 8.3 8.3 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 407 6 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1016/j.bmc.2010.10.043
53325868 57599 None 0 Rabbit Functional pKd = 8.3 8.3 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 515 12 2 6 5.8 CCCCc1nc2cc(OC)cc(C(=O)O)c2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1668002 57599 None 0 Rabbit Functional pKd = 8.3 8.3 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 515 12 2 6 5.8 CCCCc1nc2cc(OC)cc(C(=O)O)c2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1016/j.bmc.2010.10.043
44438880 91984 None 0 Rabbit Functional pKd = 8.2 8.2 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 427 7 2 7 3.7 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL241523 91984 None 0 Rabbit Functional pKd = 8.2 8.2 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 427 7 2 7 3.7 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
132706 1674 None 24 Human Functional pKd = 8.2 8.2 -1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1016/j.bmc.2010.10.043
6896 1674 None 24 Human Functional pKd = 8.2 8.2 -1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1016/j.bmc.2010.10.043
CHEMBL315021 1674 None 24 Human Functional pKd = 8.2 8.2 -1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1016/j.bmc.2010.10.043
DB01342 1674 None 24 Human Functional pKd = 8.2 8.2 -1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1016/j.bmc.2010.10.043
57380412 70526 None 0 Rabbit Functional pKd = 8.2 8.2 - 2
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947129 70526 None 0 Rabbit Functional pKd = 8.2 8.2 - 2
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
44570264 190705 None 0 Rat Functional pKd = 7.2 7.2 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 505 10 2 5 5.5 CCCCc1nc2cc(S(=O)(=O)NC(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL518230 190705 None 0 Rat Functional pKd = 7.2 7.2 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 505 10 2 5 5.5 CCCCc1nc2cc(S(=O)(=O)NC(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
25112617 186755 None 0 Rat Functional pKd = 6.2 6.2 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 537 9 2 4 7.7 CCCCc1nc2cc(NC(=O)c3ccc(Cl)cc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL488883 186755 None 0 Rat Functional pKd = 6.2 6.2 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 537 9 2 4 7.7 CCCCc1nc2cc(NC(=O)c3ccc(Cl)cc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL268804 210762 None 0 Rabbit Functional pKd = 8.1 8.1 - 0
Negative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aortaNegative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aorta
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)O)C(C)C)C(C)C 10.1021/jm9608669
44438872 169104 None 0 Rabbit Functional pKd = 7.1 7.1 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 455 8 1 8 4.2 CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL440051 169104 None 0 Rabbit Functional pKd = 7.1 7.1 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 455 8 1 8 4.2 CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
15069306 179060 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 469 10 2 4 6.5 CCCCc1nc2cc(NC(=O)CCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL471505 179060 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 469 10 2 4 6.5 CCCCc1nc2cc(NC(=O)CCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
44570217 183232 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 505 11 2 5 5.5 CCCCc1nc2cc(S(=O)(=O)NCCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL479626 183232 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 505 11 2 5 5.5 CCCCc1nc2cc(S(=O)(=O)NCCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
44570216 190055 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 491 10 2 5 5.1 CCCCc1nc2cc(S(=O)(=O)NCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL517230 190055 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 491 10 2 5 5.1 CCCCc1nc2cc(S(=O)(=O)NCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
6918269 98468 None 11 Rabbit Functional pKd = 8.0 8.0 - 2
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL275875 98468 None 11 Rabbit Functional pKd = 8.0 8.0 - 2
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL295959 98468 None 11 Rabbit Functional pKd = 8.0 8.0 - 2
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
1610 2345 None 95 Rat Functional pKi = 8.1 8.1 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
3941 2345 None 95 Rat Functional pKi = 8.1 8.1 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
3961 2345 None 95 Rat Functional pKi = 8.1 8.1 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
590 2345 None 95 Rat Functional pKi = 8.1 8.1 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
CHEMBL191 2345 None 95 Rat Functional pKi = 8.1 8.1 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
DB00678 2345 None 95 Rat Functional pKi = 8.1 8.1 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
1610 2345 None 95 Rat Functional pKi = 7.0 7.0 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
3941 2345 None 95 Rat Functional pKi = 7.0 7.0 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
3961 2345 None 95 Rat Functional pKi = 7.0 7.0 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
590 2345 None 95 Rat Functional pKi = 7.0 7.0 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
CHEMBL191 2345 None 95 Rat Functional pKi = 7.0 7.0 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
DB00678 2345 None 95 Rat Functional pKi = 7.0 7.0 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
6917 132 None 0 Human Functional pA2 = 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 348 7 1 3 4.9 CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O 22889560
73755250 132 None 0 Human Functional pA2 = 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 348 7 1 3 4.9 CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O 22889560
11943 3873 None 0 Human Functional pEC50 = 5.7 5.7 -14 2
β-arrestin recruitment assayβ-arrestin recruitment assay
Guide to Pharmacology None None None None None
145925549 3873 None 0 Human Functional pEC50 = 5.7 5.7 -14 2
β-arrestin recruitment assayβ-arrestin recruitment assay
Guide to Pharmacology None None None None None
CHEMBL4438122 3873 None 0 Human Functional pEC50 = 5.7 5.7 -14 2
β-arrestin recruitment assayβ-arrestin recruitment assay
Guide to Pharmacology None None None None None
123814 421 None 30 Human Functional pEC50 = 5.9 5.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12006574
5368 421 None 30 Human Functional pEC50 = 5.9 5.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12006574
CHEMBL261120 421 None 30 Human Functional pEC50 = 5.9 5.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12006574
6894 418 None 0 Human Functional pEC50 = 8.2 8.2 -56 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21464395
91691124 418 None 0 Human Functional pEC50 = 8.2 8.2 -56 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21464395
6905 3483 None 0 Rat Functional pEC50 = 8.8 8.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7499361
135409642 217733 None 0 Bovine Functional pIC50 = 8.2 8.2 1 2
NoneNone
Drug Central 568 9 1 11 4.7 CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 None
CHEMBL2028661 217733 None 0 Bovine Functional pIC50 = 8.2 8.2 1 2
NoneNone
Drug Central 568 9 1 11 4.7 CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 None
DB08822 217733 None 0 Bovine Functional pIC50 = 8.2 8.2 1 2
NoneNone
Drug Central 568 9 1 11 4.7 CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 None
2540 4399 None 111 Bovine Functional pIC50 = 8.2 8.2 1 28
NoneNone
Drug Central 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 None
CHEMBL1014 4399 None 111 Bovine Functional pIC50 = 8.2 8.2 1 28
NoneNone
Drug Central 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 None
3839 3755 None 84 Human Functional pIC50 = 8.1 8.1 794 2
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
Drug Central 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 None
60919 3755 None 84 Human Functional pIC50 = 8.1 8.1 794 2
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
Drug Central 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 None
6898 3755 None 84 Human Functional pIC50 = 8.1 8.1 794 2
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
Drug Central 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 None
CHEMBL432162 3755 None 84 Human Functional pIC50 = 8.1 8.1 794 2
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
Drug Central 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 None
DB01349 3755 None 84 Human Functional pIC50 = 8.1 8.1 794 2
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
Drug Central 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 None
130881 2919 None 108 Bovine Functional pIC50 = 8.1 8.1 -2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
1985 2919 None 108 Bovine Functional pIC50 = 8.1 8.1 -2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
591 2919 None 108 Bovine Functional pIC50 = 8.1 8.1 -2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
CHEMBL1200692 2919 None 108 Bovine Functional pIC50 = 8.1 8.1 -2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
DB00275 2919 None 108 Bovine Functional pIC50 = 8.1 8.1 -2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
130881 2919 None 108 Human Functional pIC50 = 8.1 8.1 2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
1985 2919 None 108 Human Functional pIC50 = 8.1 8.1 2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
591 2919 None 108 Human Functional pIC50 = 8.1 8.1 2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
CHEMBL1200692 2919 None 108 Human Functional pIC50 = 8.1 8.1 2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
DB00275 2919 None 108 Human Functional pIC50 = 8.1 8.1 2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
135409642 217733 None 0 Human Functional pIC50 = 8.1 8.1 -1 2
NoneNone
Drug Central 568 9 1 11 4.7 CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 None
CHEMBL2028661 217733 None 0 Human Functional pIC50 = 8.1 8.1 -1 2
NoneNone
Drug Central 568 9 1 11 4.7 CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 None
DB08822 217733 None 0 Human Functional pIC50 = 8.1 8.1 -1 2
NoneNone
Drug Central 568 9 1 11 4.7 CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 None
16133225 419 None 52 Human Functional pIC50 = 8.0 8.0 -5 4
NoneNone
Drug Central None None None None None
172198 419 None 52 Human Functional pIC50 = 8.0 8.0 -5 4
NoneNone
Drug Central None None None None None
2504 419 None 52 Human Functional pIC50 = 8.0 8.0 -5 4
NoneNone
Drug Central None None None None None
45266664 419 None 52 Human Functional pIC50 = 8.0 8.0 -5 4
NoneNone
Drug Central None None None None None
5272 419 None 52 Human Functional pIC50 = 8.0 8.0 -5 4
NoneNone
Drug Central None None None None None
CHEMBL408403 419 None 52 Human Functional pIC50 = 8.0 8.0 -5 4
NoneNone
Drug Central None None None None None
DB11842 419 None 52 Human Functional pIC50 = 8.0 8.0 -5 4
NoneNone
Drug Central None None None None None
9870652 70890 None 75 Human Functional pIC50 = 8.0 8.0 -15 2
antagonism of angiotensin II induced contractionantagonism of angiotensin II induced contraction
Drug Central 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 None
CHEMBL1951143 70890 None 75 Human Functional pIC50 = 8.0 8.0 -15 2
antagonism of angiotensin II induced contractionantagonism of angiotensin II induced contraction
Drug Central 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 None
DB09279 70890 None 75 Human Functional pIC50 = 8.0 8.0 -15 2
antagonism of angiotensin II induced contractionantagonism of angiotensin II induced contraction
Drug Central 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 None
1610 2345 None 95 Human Functional pIC50 = 8.0 8.0 -9 11
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 2345 None 95 Human Functional pIC50 = 8.0 8.0 -9 11
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 2345 None 95 Human Functional pIC50 = 8.0 8.0 -9 11
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 2345 None 95 Human Functional pIC50 = 8.0 8.0 -9 11
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 2345 None 95 Human Functional pIC50 = 8.0 8.0 -9 11
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 2345 None 95 Human Functional pIC50 = 8.0 8.0 -9 11
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3936 2208 None 35 Human Functional pIC50 = 7.9 7.9 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 7829475
6603900 2208 None 35 Human Functional pIC50 = 7.9 7.9 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 7829475
CHEMBL288174 2208 None 35 Human Functional pIC50 = 7.9 7.9 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 7829475
6895 2209 None 0 Human Functional pIC50 = 7.9 7.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 580 9 1 6 6.6 CCc1nc2c(n1Cc1ccc(cc1)c1cc(ccc1S(=O)(=O)NC(=O)c1ccccc1)CC(C)C)nc(cc2C)C 9383393
73755245 2209 None 0 Human Functional pIC50 = 7.9 7.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 580 9 1 6 6.6 CCc1nc2c(n1Cc1ccc(cc1)c1cc(ccc1S(=O)(=O)NC(=O)c1ccccc1)CC(C)C)nc(cc2C)C 9383393
1610 2345 None 95 Human Functional pIC50 = 8.1 8.1 -9 11
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8372104
3941 2345 None 95 Human Functional pIC50 = 8.1 8.1 -9 11
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8372104
3961 2345 None 95 Human Functional pIC50 = 8.1 8.1 -9 11
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8372104
590 2345 None 95 Human Functional pIC50 = 8.1 8.1 -9 11
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8372104
CHEMBL191 2345 None 95 Human Functional pIC50 = 8.1 8.1 -9 11
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8372104
DB00678 2345 None 95 Human Functional pIC50 = 8.1 8.1 -9 11
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8372104
139031070 2837 None 0 Human Functional pIC50 = 8.1 8.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 714 11 0 10 2.6 CCCCc1n([c+]nc1Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na])Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na].[Br-] 23376252
6911 2837 None 0 Human Functional pIC50 = 8.1 8.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 714 11 0 10 2.6 CCCCc1n([c+]nc1Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na])Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na].[Br-] 23376252
73755247 2837 None 0 Human Functional pIC50 = 8.1 8.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 714 11 0 10 2.6 CCCCc1n([c+]nc1Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na])Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na].[Br-] 23376252
130881 2919 None 108 Human Functional pIC50 = 8.1 8.1 2 3
UnclassifiedUnclassified
Guide to Pharmacology 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 11451212
1985 2919 None 108 Human Functional pIC50 = 8.1 8.1 2 3
UnclassifiedUnclassified
Guide to Pharmacology 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 11451212
591 2919 None 108 Human Functional pIC50 = 8.1 8.1 2 3
UnclassifiedUnclassified
Guide to Pharmacology 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 11451212
CHEMBL1200692 2919 None 108 Human Functional pIC50 = 8.1 8.1 2 3
UnclassifiedUnclassified
Guide to Pharmacology 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 11451212
DB00275 2919 None 108 Human Functional pIC50 = 8.1 8.1 2 3
UnclassifiedUnclassified
Guide to Pharmacology 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 11451212
135415867 560 None 97 Human Functional pIC50 = 8.1 8.1 53 2
UnclassifiedUnclassified
Guide to Pharmacology 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 24739538
135415867 560 None 97 Human Functional pIC50 = 8.1 8.1 53 2
UnclassifiedUnclassified
Guide to Pharmacology 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 24742498
6901 560 None 97 Human Functional pIC50 = 8.1 8.1 53 2
UnclassifiedUnclassified
Guide to Pharmacology 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 24739538
6901 560 None 97 Human Functional pIC50 = 8.1 8.1 53 2
UnclassifiedUnclassified
Guide to Pharmacology 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 24742498
CHEMBL57242 560 None 97 Human Functional pIC50 = 8.1 8.1 53 2
UnclassifiedUnclassified
Guide to Pharmacology 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 24739538
CHEMBL57242 560 None 97 Human Functional pIC50 = 8.1 8.1 53 2
UnclassifiedUnclassified
Guide to Pharmacology 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 24742498
6909 2406 None 0 Human Functional pIC50 = 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 642 14 4 9 3.7 CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O 11303957
73755246 2406 None 0 Human Functional pIC50 = 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 642 14 4 9 3.7 CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O 11303957
10416728 2407 None 0 Human Functional pIC50 = 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 642 14 4 9 3.7 CCCCCC[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O 11303957
6910 2407 None 0 Human Functional pIC50 = 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 642 14 4 9 3.7 CCCCCC[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O 11303957
CHEMBL344662 2407 None 0 Human Functional pIC50 = 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 642 14 4 9 3.7 CCCCCC[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O 11303957
132706 1674 None 24 Rat Functional pIC50 = 8.4 8.4 1 2
UnclassifiedUnclassified
Guide to Pharmacology 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 7505365
6896 1674 None 24 Rat Functional pIC50 = 8.4 8.4 1 2
UnclassifiedUnclassified
Guide to Pharmacology 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 7505365
CHEMBL315021 1674 None 24 Rat Functional pIC50 = 8.4 8.4 1 2
UnclassifiedUnclassified
Guide to Pharmacology 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 7505365
DB01342 1674 None 24 Rat Functional pIC50 = 8.4 8.4 1 2
UnclassifiedUnclassified
Guide to Pharmacology 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 7505365
2583 3774 None 118 Human Functional pIC50 = 8.4 8.4 -1 16
UnclassifiedUnclassified
Guide to Pharmacology 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 9878991
592 3774 None 118 Human Functional pIC50 = 8.4 8.4 -1 16
UnclassifiedUnclassified
Guide to Pharmacology 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 9878991
65999 3774 None 118 Human Functional pIC50 = 8.4 8.4 -1 16
UnclassifiedUnclassified
Guide to Pharmacology 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 9878991
CHEMBL1017 3774 None 118 Human Functional pIC50 = 8.4 8.4 -1 16
UnclassifiedUnclassified
Guide to Pharmacology 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 9878991
DB00966 3774 None 118 Human Functional pIC50 = 8.4 8.4 -1 16
UnclassifiedUnclassified
Guide to Pharmacology 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 9878991
4673492 4136 None 9 Guinea pig Functional pIC50 = 8.4 8.4 5248 2
UnclassifiedUnclassified
Guide to Pharmacology 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 8576904
8324 4136 None 9 Guinea pig Functional pIC50 = 8.4 8.4 5248 2
UnclassifiedUnclassified
Guide to Pharmacology 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 8576904
CHEMBL159096 4136 None 9 Guinea pig Functional pIC50 = 8.4 8.4 5248 2
UnclassifiedUnclassified
Guide to Pharmacology 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 8576904
108185 1612 None 78 Human Functional pIC50 = 8.4 8.4 3 5
UnclassifiedUnclassified
Guide to Pharmacology 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10193788
108185 1612 None 78 Human Functional pIC50 = 8.4 8.4 3 5
UnclassifiedUnclassified
Guide to Pharmacology 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 8372104
586 1612 None 78 Human Functional pIC50 = 8.4 8.4 3 5
UnclassifiedUnclassified
Guide to Pharmacology 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10193788
586 1612 None 78 Human Functional pIC50 = 8.4 8.4 3 5
UnclassifiedUnclassified
Guide to Pharmacology 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 8372104
CHEMBL907 1612 None 78 Human Functional pIC50 = 8.4 8.4 3 5
UnclassifiedUnclassified
Guide to Pharmacology 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10193788
CHEMBL907 1612 None 78 Human Functional pIC50 = 8.4 8.4 3 5
UnclassifiedUnclassified
Guide to Pharmacology 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 8372104
44299731 420 None 0 Human Functional pIC50 = 8.5 8.5 -2 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
585 420 None 0 Human Functional pIC50 = 8.5 8.5 -2 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
CHEMBL56448 420 None 0 Human Functional pIC50 = 8.5 8.5 -2 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
6917 132 None 0 Human Functional pIC50 = 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 348 7 1 3 4.9 CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O 22889560
73755250 132 None 0 Human Functional pIC50 = 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 348 7 1 3 4.9 CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O 22889560
1037 1576 None 69 Human Functional pIC50 = 8.6 8.6 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 1309870
3940 1576 None 69 Human Functional pIC50 = 8.6 8.6 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 1309870
5281037 1576 None 69 Human Functional pIC50 = 8.6 8.6 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 1309870
588 1576 None 69 Human Functional pIC50 = 8.6 8.6 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 1309870
CHEMBL813 1576 None 69 Human Functional pIC50 = 8.6 8.6 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 1309870
DB00876 1576 None 69 Human Functional pIC50 = 8.6 8.6 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 1309870
2806 3967 None 110 Human Functional pIC50 = 8.6 8.6 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 8577935
3937 3967 None 110 Human Functional pIC50 = 8.6 8.6 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 8577935
593 3967 None 110 Human Functional pIC50 = 8.6 8.6 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 8577935
60846 3967 None 110 Human Functional pIC50 = 8.6 8.6 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 8577935
CHEMBL1069 3967 None 110 Human Functional pIC50 = 8.6 8.6 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 8577935
DB00177 3967 None 110 Human Functional pIC50 = 8.6 8.6 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 8577935
1481 2064 None 116 Human Functional pIC50 = 8.8 8.8 -2 6
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10193788
3749 2064 None 116 Human Functional pIC50 = 8.8 8.8 -2 6
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10193788
589 2064 None 116 Human Functional pIC50 = 8.8 8.8 -2 6
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10193788
6908 2064 None 116 Human Functional pIC50 = 8.8 8.8 -2 6
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10193788
CHEMBL1513 2064 None 116 Human Functional pIC50 = 8.8 8.8 -2 6
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10193788
DB01029 2064 None 116 Human Functional pIC50 = 8.8 8.8 -2 6
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10193788
136218976 150 None 0 Rat Functional pIC50 = 8.8 8.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 423 9 2 5 3.7 CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O 22410249
6913 150 None 0 Rat Functional pIC50 = 8.8 8.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 423 9 2 5 3.7 CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O 22410249
2806 3967 None 110 Human Functional pIC50 = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 11206708
3937 3967 None 110 Human Functional pIC50 = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 11206708
593 3967 None 110 Human Functional pIC50 = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 11206708
60846 3967 None 110 Human Functional pIC50 = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 11206708
CHEMBL1069 3967 None 110 Human Functional pIC50 = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 11206708
DB00177 3967 None 110 Human Functional pIC50 = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 11206708
3839 3755 None 84 Human Functional pIC50 = 8.9 8.9 794 2
UnclassifiedUnclassified
Guide to Pharmacology 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 11046101
60919 3755 None 84 Human Functional pIC50 = 8.9 8.9 794 2
UnclassifiedUnclassified
Guide to Pharmacology 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 11046101
6898 3755 None 84 Human Functional pIC50 = 8.9 8.9 794 2
UnclassifiedUnclassified
Guide to Pharmacology 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 11046101
CHEMBL432162 3755 None 84 Human Functional pIC50 = 8.9 8.9 794 2
UnclassifiedUnclassified
Guide to Pharmacology 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 11046101
DB01349 3755 None 84 Human Functional pIC50 = 8.9 8.9 794 2
UnclassifiedUnclassified
Guide to Pharmacology 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 11046101
16133225 419 None 52 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10193788
172198 419 None 52 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10193788
2504 419 None 52 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10193788
45266664 419 None 52 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10193788
5272 419 None 52 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10193788
CHEMBL408403 419 None 52 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10193788
DB11842 419 None 52 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10193788
6894 418 None 0 Rat Functional pIC50 = 9.5 9.5 -2 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17138938
91691124 418 None 0 Rat Functional pIC50 = 9.5 9.5 -2 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17138938
2541 785 None 120 Human Functional pIC50 = 9.6 9.6 15 10
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10193788
587 785 None 120 Human Functional pIC50 = 9.6 9.6 15 10
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10193788
6907 785 None 120 Human Functional pIC50 = 9.6 9.6 15 10
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10193788
CHEMBL1016 785 None 120 Human Functional pIC50 = 9.6 9.6 15 10
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10193788
DB00796 785 None 120 Human Functional pIC50 = 9.6 9.6 15 10
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10193788
DB13919 785 None 120 Human Functional pIC50 = 9.6 9.6 15 10
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10193788


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
2541 785 None 120 Human Binding pAC50 = 9.4 9.4 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
587 785 None 120 Human Binding pAC50 = 9.4 9.4 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
6907 785 None 120 Human Binding pAC50 = 9.4 9.4 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL1016 785 None 120 Human Binding pAC50 = 9.4 9.4 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
DB00796 785 None 120 Human Binding pAC50 = 9.4 9.4 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
DB13919 785 None 120 Human Binding pAC50 = 9.4 9.4 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
158781 44164 None 98 Human Binding pAC50 = 9.4 9.4 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1038/s41467-023-40064-9
CHEMBL1516 44164 None 98 Human Binding pAC50 = 9.4 9.4 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1038/s41467-023-40064-9
2541 785 None 120 Human Binding pAC50 = 9.3 9.3 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
587 785 None 120 Human Binding pAC50 = 9.3 9.3 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
6907 785 None 120 Human Binding pAC50 = 9.3 9.3 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL1016 785 None 120 Human Binding pAC50 = 9.3 9.3 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
DB00796 785 None 120 Human Binding pAC50 = 9.3 9.3 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
DB13919 785 None 120 Human Binding pAC50 = 9.3 9.3 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
1481 2064 None 116 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
3749 2064 None 116 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
589 2064 None 116 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
6908 2064 None 116 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
CHEMBL1513 2064 None 116 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
DB01029 2064 None 116 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
158781 44164 None 98 Human Binding pAC50 = 9.1 9.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1038/s41467-023-40064-9
CHEMBL1516 44164 None 98 Human Binding pAC50 = 9.1 9.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1038/s41467-023-40064-9
1481 2064 None 116 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
3749 2064 None 116 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
589 2064 None 116 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
6908 2064 None 116 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
CHEMBL1513 2064 None 116 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
DB01029 2064 None 116 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
130881 2919 None 108 Human Binding pAC50 = 9.1 9.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
1985 2919 None 108 Human Binding pAC50 = 9.1 9.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
591 2919 None 108 Human Binding pAC50 = 9.1 9.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
CHEMBL1200692 2919 None 108 Human Binding pAC50 = 9.1 9.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
DB00275 2919 None 108 Human Binding pAC50 = 9.1 9.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
2583 3774 None 118 Human Binding pAC50 = 9 9.0 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
592 3774 None 118 Human Binding pAC50 = 9 9.0 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
65999 3774 None 118 Human Binding pAC50 = 9 9.0 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
CHEMBL1017 3774 None 118 Human Binding pAC50 = 9 9.0 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
DB00966 3774 None 118 Human Binding pAC50 = 9 9.0 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
1481 2064 None 116 Human Binding pAC50 = 8.8 8.8 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
3749 2064 None 116 Human Binding pAC50 = 8.8 8.8 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
589 2064 None 116 Human Binding pAC50 = 8.8 8.8 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
6908 2064 None 116 Human Binding pAC50 = 8.8 8.8 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
CHEMBL1513 2064 None 116 Human Binding pAC50 = 8.8 8.8 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
DB01029 2064 None 116 Human Binding pAC50 = 8.8 8.8 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
130881 2919 None 108 Human Binding pAC50 = 8.8 8.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
1985 2919 None 108 Human Binding pAC50 = 8.8 8.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
591 2919 None 108 Human Binding pAC50 = 8.8 8.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
CHEMBL1200692 2919 None 108 Human Binding pAC50 = 8.8 8.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
DB00275 2919 None 108 Human Binding pAC50 = 8.8 8.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
1037 1576 None 69 Human Binding pAC50 = 8.7 8.7 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
3940 1576 None 69 Human Binding pAC50 = 8.7 8.7 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
5281037 1576 None 69 Human Binding pAC50 = 8.7 8.7 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
588 1576 None 69 Human Binding pAC50 = 8.7 8.7 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
CHEMBL813 1576 None 69 Human Binding pAC50 = 8.7 8.7 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
DB00876 1576 None 69 Human Binding pAC50 = 8.7 8.7 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
242 470 None 124 Human Binding pAC50 = 6 6.0 - 52
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
34 470 None 124 Human Binding pAC50 = 6 6.0 - 52
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795 470 None 124 Human Binding pAC50 = 6 6.0 - 52
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
CHEMBL1112 470 None 124 Human Binding pAC50 = 6 6.0 - 52
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
DB01238 470 None 124 Human Binding pAC50 = 6 6.0 - 52
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
216239 23793 None 118 Human Binding pAC50 = 5.0 5.0 - 7
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
CHEMBL1200485 23793 None 118 Human Binding pAC50 = 5.0 5.0 - 7
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
CHEMBL1336 23793 None 118 Human Binding pAC50 = 5.0 5.0 - 7
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
25181577 78217 None 56 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 574 9 2 9 5.0 CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 10.1038/s41467-023-40064-9
CHEMBL2105695 78217 None 56 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 574 9 2 9 5.0 CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 10.1038/s41467-023-40064-9
54682461 84684 None 62 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 602 11 2 6 7.3 CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 10.1038/s41467-023-40064-9
CHEMBL222559 84684 None 62 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 602 11 2 6 7.3 CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 10.1038/s41467-023-40064-9
441290 14475 None 36 Human Binding pAC50 = 5.9 5.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 5 1 5 4.4 C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1 10.1038/s41467-023-40064-9
CHEMBL1201244 14475 None 36 Human Binding pAC50 = 5.9 5.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 5 1 5 4.4 C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1 10.1038/s41467-023-40064-9
DB00728 14475 None 36 Human Binding pAC50 = 5.9 5.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 5 1 5 4.4 C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1 10.1038/s41467-023-40064-9
65948 18554 None 109 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 582 9 2 9 4.7 CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 10.1038/s41467-023-40064-9
CHEMBL1275868 18554 None 109 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 582 9 2 9 4.7 CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 10.1038/s41467-023-40064-9
5077 3576 None 79 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
7552 3576 None 79 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
9913767 3576 None 79 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
CHEMBL238804 3576 None 79 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
DB11362 3576 None 79 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
64139 84783 None 96 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
CHEMBL223228 84783 None 96 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
2540 4399 None 111 Human Binding pAC50 = 7.9 7.9 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
CHEMBL1014 4399 None 111 Human Binding pAC50 = 7.9 7.9 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
180 401 None 56 Human Binding pAC50 = 5.9 5.9 - 40
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
200 401 None 56 Human Binding pAC50 = 5.9 5.9 - 40
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
2160 401 None 56 Human Binding pAC50 = 5.9 5.9 - 40
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
CHEMBL629 401 None 56 Human Binding pAC50 = 5.9 5.9 - 40
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
DB00321 401 None 56 Human Binding pAC50 = 5.9 5.9 - 40
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
3149 12612 None 15 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1187011 12612 None 15 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
1549120 196484 None 85 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL56337 196484 None 85 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
5281034 14424 None 29 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 332 0 2 3 4.4 C[C@]12C/C(=C/O)C(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O 10.1038/s41467-023-40064-9
CHEMBL1200585 14424 None 29 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 332 0 2 3 4.4 C[C@]12C/C(=C/O)C(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O 10.1038/s41467-023-40064-9
3599 16877 None 88 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 20 0 4 5.7 CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C 10.1038/s41467-023-40064-9
CHEMBL125 16877 None 88 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 20 0 4 5.7 CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C 10.1038/s41467-023-40064-9
5591 157529 None 90 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
CHEMBL408 157529 None 90 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
3152 188409 None 103 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 379 6 0 4 4.4 COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 10.1038/s41467-023-40064-9
CHEMBL502 188409 None 103 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 379 6 0 4 4.4 COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 10.1038/s41467-023-40064-9
2333 142333 None 97 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
CHEMBL388590 142333 None 97 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
5803 162225 None 84 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 622 4 2 3 4.6 O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 10.1038/s41467-023-40064-9
CHEMBL41632 162225 None 84 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 622 4 2 3 4.6 O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 10.1038/s41467-023-40064-9
104850 3328 None 96 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
4150 3328 None 96 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
743 3328 None 96 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
CHEMBL111 3328 None 96 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
DB06155 3328 None 96 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
2540 4399 None 111 Human Binding pAC50 = 7.8 7.8 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
CHEMBL1014 4399 None 111 Human Binding pAC50 = 7.8 7.8 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
5852 2615 None 55 Human Binding pAC50 = 4.8 4.8 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
9931891 2615 None 55 Human Binding pAC50 = 4.8 4.8 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
CHEMBL239226 2615 None 55 Human Binding pAC50 = 4.8 4.8 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
5318 15574 None 49 Human Binding pAC50 = 4.8 4.8 - 13
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1200348 15574 None 49 Human Binding pAC50 = 4.8 4.8 - 13
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1221 15574 None 49 Human Binding pAC50 = 4.8 4.8 - 13
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 10.1038/s41467-023-40064-9
1385580 29274 None 76 Human Binding pAC50 = 4.8 4.8 - 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
4615 29274 None 76 Human Binding pAC50 = 4.8 4.8 - 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL13828 29274 None 76 Human Binding pAC50 = 4.8 4.8 - 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
DB12877 29274 None 76 Human Binding pAC50 = 4.8 4.8 - 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
1056 3369 None 116 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1038/s41467-023-40064-9
2405 3369 None 116 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1038/s41467-023-40064-9
77999 3369 None 116 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1038/s41467-023-40064-9
CHEMBL121 3369 None 116 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1038/s41467-023-40064-9
DB00412 3369 None 116 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1038/s41467-023-40064-9
40973 46033 None 70 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 1 1 1 4.9 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC 10.1038/s41467-023-40064-9
CHEMBL1533 46033 None 70 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 1 1 1 4.9 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC 10.1038/s41467-023-40064-9
135409453 3771 None 41 Human Binding pAC50 = 5.8 5.8 - 2
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
226 3771 None 41 Human Binding pAC50 = 5.8 5.8 - 2
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
CHEMBL76370 3771 None 41 Human Binding pAC50 = 5.8 5.8 - 2
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
3516 208121 None 100 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 198 5 2 4 0.4 COc1ccccc1OCC(O)CO 10.1038/s41467-023-40064-9
CHEMBL980 208121 None 100 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 198 5 2 4 0.4 COc1ccccc1OCC(O)CO 10.1038/s41467-023-40064-9
135398735 136966 None 32 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
136262914 136966 None 32 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL374478 136966 None 32 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
72093 35059 None 9 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL1433361 35059 None 9 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL2103773 35059 None 9 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
4495 196533 None 92 Human Binding pAC50 = 4.7 4.7 - 30
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL56367 196533 None 92 Human Binding pAC50 = 4.7 4.7 - 30
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 10.1038/s41467-023-40064-9
2303 3185 None 68 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
4946 3185 None 68 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
564 3185 None 68 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
63 3185 None 68 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
91536 3185 None 68 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL27 3185 None 68 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL452861 3185 None 68 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
DB00571 3185 None 68 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
25025298 78149 None 39 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 546 8 3 8 4.5 Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1 10.1038/s41467-023-40064-9
CHEMBL2103855 78149 None 39 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 546 8 3 8 4.5 Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1 10.1038/s41467-023-40064-9
5280453 205969 None 74 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 416 6 3 3 5.7 C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O 10.1038/s41467-023-40064-9
CHEMBL846 205969 None 74 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 416 6 3 3 5.7 C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O 10.1038/s41467-023-40064-9
54454 5256 None 88 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 418 6 1 5 4.6 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
CHEMBL1064 5256 None 88 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 418 6 1 5 4.6 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
6540478 14445 None 41 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 2 1 4 4.7 C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC 10.1038/s41467-023-40064-9
CHEMBL1200934 14445 None 41 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 2 1 4 4.7 C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC 10.1038/s41467-023-40064-9
51755 57404 None 54 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 454 8 0 4 7.3 Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1651990 57404 None 54 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 454 8 0 4 7.3 Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 10.1038/s41467-023-40064-9
1353 1909 None 93 Human Binding pAC50 = 4.6 4.6 -6918 86
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
3559 1909 None 93 Human Binding pAC50 = 4.6 4.6 -6918 86
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
86 1909 None 93 Human Binding pAC50 = 4.6 4.6 -6918 86
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
CHEMBL54 1909 None 93 Human Binding pAC50 = 4.6 4.6 -6918 86
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
DB00502 1909 None 93 Human Binding pAC50 = 4.6 4.6 -6918 86
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
11980903 14490 None 19 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
22526 14490 None 19 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
5281035 14490 None 19 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1201303 14490 None 19 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
5564 206004 None 118 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 288 2 1 2 5.1 Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl 10.1038/s41467-023-40064-9
CHEMBL849 206004 None 118 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 288 2 1 2 5.1 Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl 10.1038/s41467-023-40064-9
3899 207772 None 119 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 270 2 1 3 3.3 Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1038/s41467-023-40064-9
CHEMBL960 207772 None 119 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 270 2 1 3 3.3 Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1038/s41467-023-40064-9
24826799 10796 None 104 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 532 4 1 6 4.5 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 10.1038/s41467-023-40064-9
CHEMBL1171837 10796 None 104 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 532 4 1 6 4.5 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 10.1038/s41467-023-40064-9
2335 11846 None 22 Human Binding pAC50 = 4.6 4.6 - 12
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
8478 11846 None 22 Human Binding pAC50 = 4.6 4.6 - 12
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL1182210 11846 None 22 Human Binding pAC50 = 4.6 4.6 - 12
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL221753 11846 None 22 Human Binding pAC50 = 4.6 4.6 - 12
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
2585 802 None 103 Human Binding pAC50 = 6.6 6.6 - 22
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
522 802 None 103 Human Binding pAC50 = 6.6 6.6 - 22
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
551 802 None 103 Human Binding pAC50 = 6.6 6.6 - 22
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
CHEMBL723 802 None 103 Human Binding pAC50 = 6.6 6.6 - 22
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
DB01136 802 None 103 Human Binding pAC50 = 6.6 6.6 - 22
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
1610 2345 None 95 Human Binding pAC50 = 7.6 7.6 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3941 2345 None 95 Human Binding pAC50 = 7.6 7.6 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3961 2345 None 95 Human Binding pAC50 = 7.6 7.6 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
590 2345 None 95 Human Binding pAC50 = 7.6 7.6 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
CHEMBL191 2345 None 95 Human Binding pAC50 = 7.6 7.6 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
DB00678 2345 None 95 Human Binding pAC50 = 7.6 7.6 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
16220172 73041 None 95 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 2 3 3 5.1 CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O 10.1038/s41467-023-40064-9
CHEMBL2010601 73041 None 95 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 2 3 3 5.1 CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O 10.1038/s41467-023-40064-9
3926 207239 None 40 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
CHEMBL92870 207239 None 40 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
54585 14500 None 85 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 4 6 2.7 O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 10.1038/s41467-023-40064-9
CHEMBL1201346 14500 None 85 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 4 6 2.7 O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 10.1038/s41467-023-40064-9
2812 4777 None 101 Human Binding pAC50 = 4.6 4.6 - 34
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 10.1038/s41467-023-40064-9
CHEMBL104 4777 None 101 Human Binding pAC50 = 4.6 4.6 - 34
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 10.1038/s41467-023-40064-9
11626560 200935 None 94 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 449 5 2 6 5.0 C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl 10.1038/s41467-023-40064-9
CHEMBL601719 200935 None 94 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 449 5 2 6 5.0 C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl 10.1038/s41467-023-40064-9
47472 19435 None 57 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 410 7 0 3 6.6 Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1295 19435 None 57 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 410 7 0 3 6.6 Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 10.1038/s41467-023-40064-9
16362 3123 None 71 Human Binding pAC50 = 4.5 4.5 - 30
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2172 3123 None 71 Human Binding pAC50 = 4.5 4.5 - 30
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
90 3123 None 71 Human Binding pAC50 = 4.5 4.5 - 30
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL1423 3123 None 71 Human Binding pAC50 = 4.5 4.5 - 30
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB01100 3123 None 71 Human Binding pAC50 = 4.5 4.5 - 30
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
392622 56310 None 95 Human Binding pAC50 = 4.5 4.5 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
CHEMBL163 56310 None 95 Human Binding pAC50 = 4.5 4.5 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
4485 69377 None 118 Human Binding pAC50 = 4.4 4.4 - 8
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 346 4 1 7 2.2 COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] 10.1038/s41467-023-40064-9
CHEMBL193 69377 None 118 Human Binding pAC50 = 4.4 4.4 - 8
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 346 4 1 7 2.2 COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] 10.1038/s41467-023-40064-9
53232 188623 None 95 Human Binding pAC50 = 4.4 4.4 - 2
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
CHEMBL503 188623 None 95 Human Binding pAC50 = 4.4 4.4 - 2
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
1037 1576 None 69 Human Binding pAC50 = 8.4 8.4 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
3940 1576 None 69 Human Binding pAC50 = 8.4 8.4 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
5281037 1576 None 69 Human Binding pAC50 = 8.4 8.4 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
588 1576 None 69 Human Binding pAC50 = 8.4 8.4 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
CHEMBL813 1576 None 69 Human Binding pAC50 = 8.4 8.4 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
DB00876 1576 None 69 Human Binding pAC50 = 8.4 8.4 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
5329102 194724 None 86 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
CHEMBL535 194724 None 86 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
1037 1576 None 69 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
3940 1576 None 69 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
5281037 1576 None 69 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
588 1576 None 69 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
CHEMBL813 1576 None 69 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
DB00876 1576 None 69 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
1610 2345 None 95 Human Binding pAC50 = 8.3 8.3 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3941 2345 None 95 Human Binding pAC50 = 8.3 8.3 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3961 2345 None 95 Human Binding pAC50 = 8.3 8.3 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
590 2345 None 95 Human Binding pAC50 = 8.3 8.3 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
CHEMBL191 2345 None 95 Human Binding pAC50 = 8.3 8.3 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
DB00678 2345 None 95 Human Binding pAC50 = 8.3 8.3 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
1037 1576 None 69 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
3940 1576 None 69 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
5281037 1576 None 69 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
588 1576 None 69 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
CHEMBL813 1576 None 69 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
DB00876 1576 None 69 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
2855 4130 None 104 Human Binding pAC50 = 4.3 4.3 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
3322 4130 None 104 Human Binding pAC50 = 4.3 4.3 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
5717 4130 None 104 Human Binding pAC50 = 4.3 4.3 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
CHEMBL603 4130 None 104 Human Binding pAC50 = 4.3 4.3 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
DB00549 4130 None 104 Human Binding pAC50 = 4.3 4.3 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
3333 40166 None 111 Human Binding pAC50 = 4.3 4.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 5 4.0 CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl 10.1038/s41467-023-40064-9
CHEMBL1480 40166 None 111 Human Binding pAC50 = 4.3 4.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 5 4.0 CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl 10.1038/s41467-023-40064-9
41684 31219 None 105 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
CHEMBL1401 31219 None 105 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
146015366 208400 None 79 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 9 5 4 0.5 CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O 10.1038/s41467-023-40064-9
60852 208400 None 79 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 9 5 4 0.5 CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O 10.1038/s41467-023-40064-9
CHEMBL997 208400 None 79 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 9 5 4 0.5 CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O 10.1038/s41467-023-40064-9
275196 125671 None 52 Human Binding pAC50 = 6.2 6.2 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 4 0 8 2.9 COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C 10.1038/s41467-023-40064-9
CHEMBL364713 125671 None 52 Human Binding pAC50 = 6.2 6.2 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 4 0 8 2.9 COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C 10.1038/s41467-023-40064-9
4494 190185 None 87 Human Binding pAC50 = 4.2 4.2 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 385 5 1 8 2.5 COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
CHEMBL517427 190185 None 87 Human Binding pAC50 = 4.2 4.2 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 385 5 1 8 2.5 COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
5282219 35867 None 63 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 450 12 1 5 5.7 CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 10.1038/s41467-023-40064-9
CHEMBL1441961 35867 None 63 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 450 12 1 5 5.7 CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 10.1038/s41467-023-40064-9
135565674 194842 None 102 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 627 15 3 10 5.8 CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 10.1038/s41467-023-40064-9
213023 194842 None 102 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 627 15 3 10 5.8 CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 10.1038/s41467-023-40064-9
6445226 194842 None 102 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 627 15 3 10 5.8 CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 10.1038/s41467-023-40064-9
9578572 194842 None 102 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 627 15 3 10 5.8 CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 10.1038/s41467-023-40064-9
CHEMBL539697 194842 None 102 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 627 15 3 10 5.8 CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 10.1038/s41467-023-40064-9
4209 3161 None 75 Human Binding pAC50 = 5.1 5.1 - 33
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
4893 3161 None 75 Human Binding pAC50 = 5.1 5.1 - 33
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
503 3161 None 75 Human Binding pAC50 = 5.1 5.1 - 33
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
5385 3161 None 75 Human Binding pAC50 = 5.1 5.1 - 33
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
CHEMBL2 3161 None 75 Human Binding pAC50 = 5.1 5.1 - 33
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
DB00457 3161 None 75 Human Binding pAC50 = 5.1 5.1 - 33
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
5282181 53521 None 60 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 400 6 2 2 6.6 C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]23)C[C@@H](O)C[C@@H]1O 10.1038/s41467-023-40064-9
CHEMBL1601669 53521 None 60 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 400 6 2 2 6.6 C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]23)C[C@@H](O)C[C@@H]1O 10.1038/s41467-023-40064-9
CHEMBL5314356 194595 None 0 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
135564886 14491 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
135673376 14491 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
137157436 14491 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
145948239 14491 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
71587099 14491 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
CHEMBL1201304 14491 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
1610 2345 None 95 Human Binding pAC50 = 8 8.0 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3941 2345 None 95 Human Binding pAC50 = 8 8.0 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3961 2345 None 95 Human Binding pAC50 = 8 8.0 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
590 2345 None 95 Human Binding pAC50 = 8 8.0 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
CHEMBL191 2345 None 95 Human Binding pAC50 = 8 8.0 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
DB00678 2345 None 95 Human Binding pAC50 = 8 8.0 1 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
2194 63081 None 101 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 240 2 0 4 4.2 COc1ccc(-c2cc(=S)ss2)cc1 10.1038/s41467-023-40064-9
CHEMBL178862 63081 None 101 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 240 2 0 4 4.2 COc1ccc(-c2cc(=S)ss2)cc1 10.1038/s41467-023-40064-9
71329 179267 None 102 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 441 11 2 6 2.0 CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1 10.1038/s41467-023-40064-9
CHEMBL473 179267 None 102 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 441 11 2 6 2.0 CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1 10.1038/s41467-023-40064-9
155540547 172519 None 0 Human Binding pEC50 = 8 8.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 13 -2.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4483576 172519 None 0 Human Binding pEC50 = 8 8.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 13 -2.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155539027 172822 None 0 Rat Binding pEC50 = 8 8.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 944 26 13 12 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4514079 172822 None 0 Rat Binding pEC50 = 8 8.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 944 26 13 12 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155541295 173009 None 0 Human Binding pEC50 = 7 7.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4518318 173009 None 0 Human Binding pEC50 = 7 7.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155547844 173696 None 0 Human Binding pEC50 = 7 7.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 942 26 14 13 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4535678 173696 None 0 Human Binding pEC50 = 7 7.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 942 26 14 13 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155565112 175497 None 0 Rat Binding pEC50 = 7 7.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1081 26 13 12 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4577692 175497 None 0 Rat Binding pEC50 = 7 7.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1081 26 13 12 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155546362 173549 None 0 Human Binding pEC50 = 6 6.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 26 12 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4532075 173549 None 0 Human Binding pEC50 = 6 6.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 26 12 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155568289 176125 None 0 Human Binding pEC50 = 6 6.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 898 26 11 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4592000 176125 None 0 Human Binding pEC50 = 6 6.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 898 26 11 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155557139 174542 None 0 Human Binding pEC50 = 5 5.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 980 26 12 12 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4556070 174542 None 0 Human Binding pEC50 = 5 5.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 980 26 12 12 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155520024 173244 None 0 Rat Binding pEC50 = 5 5.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 27 13 12 -1.6 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4524570 173244 None 0 Rat Binding pEC50 = 5 5.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 27 13 12 -1.6 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155557139 174542 None 0 Rat Binding pEC50 = 5 5.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 980 26 12 12 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4556070 174542 None 0 Rat Binding pEC50 = 5 5.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 980 26 12 12 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL938 215905 None 28 Human Binding pEC50 = 8.0 8.0 1 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
155544988 173440 None 0 Rat Binding pEC50 = 7.0 7.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 853 24 12 11 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O nan
CHEMBL4529051 173440 None 0 Rat Binding pEC50 = 7.0 7.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 853 24 12 11 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O nan
155541440 173017 None 0 Human Binding pEC50 = 7.9 7.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
CHEMBL4518530 173017 None 0 Human Binding pEC50 = 7.9 7.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
155540033 172888 None 0 Rat Binding pEC50 = 6.9 6.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
CHEMBL4515768 172888 None 0 Rat Binding pEC50 = 6.9 6.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
155541125 172963 None 0 Rat Binding pEC50 = 6.9 6.9 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
CHEMBL4517561 172963 None 0 Rat Binding pEC50 = 6.9 6.9 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
155540470 172474 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.3 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4482867 172474 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.3 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155559120 174784 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -1.8 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4561769 174784 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -1.8 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155564502 175258 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4572408 175258 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
54696627 98344 None 0 Bovine Binding pEC50 = 5.9 5.9 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 486 5 2 7 5.0 Cc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 10.1016/S0960-894X(01)81134-3
CHEMBL27511 98344 None 0 Bovine Binding pEC50 = 5.9 5.9 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 486 5 2 7 5.0 Cc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 10.1016/S0960-894X(01)81134-3
54726669 99268 None 0 Bovine Binding pEC50 = 5.9 5.9 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 461 5 2 6 4.6 O=c1c(-c2ccccc2)c(O)c2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2 10.1016/S0960-894X(01)81134-3
CHEMBL281887 99268 None 0 Bovine Binding pEC50 = 5.9 5.9 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 461 5 2 6 4.6 O=c1c(-c2ccccc2)c(O)c2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2 10.1016/S0960-894X(01)81134-3
155539027 172822 None 0 Human Binding pEC50 = 7.9 7.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 944 26 13 12 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4514079 172822 None 0 Human Binding pEC50 = 7.9 7.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 944 26 13 12 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155547428 173613 None 0 Rat Binding pEC50 = 7.9 7.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4533618 173613 None 0 Rat Binding pEC50 = 7.9 7.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155550799 174272 None 0 Rat Binding pEC50 = 7.9 7.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4549405 174272 None 0 Rat Binding pEC50 = 7.9 7.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155543091 173178 None 0 Rat Binding pEC50 = 6.9 6.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4522246 173178 None 0 Rat Binding pEC50 = 6.9 6.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155520014 173234 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 27 14 13 -1.9 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4524300 173234 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 27 14 13 -1.9 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL2028943 209133 None 0 Rat Binding pEC50 = 7.9 7.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
CHEMBL2370909 209946 None 0 Rat Binding pEC50 = 6.9 6.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155542907 173175 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
CHEMBL4522038 173175 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
155563676 175342 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4574199 175342 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL2392353 210412 None 6 Rat Binding pEC50 = 7.8 7.8 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
3082475 3875 None 16 Rat Binding pEC50 = 7.8 7.8 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
6902 3875 None 16 Rat Binding pEC50 = 7.8 7.8 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4297447 3875 None 16 Rat Binding pEC50 = 7.8 7.8 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
DB12199 3875 None 16 Rat Binding pEC50 = 7.8 7.8 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155568804 176118 None 0 Rat Binding pEC50 = 7.8 7.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4591857 176118 None 0 Rat Binding pEC50 = 7.8 7.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155541240 173014 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 928 26 12 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4518420 173014 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 928 26 12 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155563538 175298 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
CHEMBL4573250 175298 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
155554529 174631 None 0 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4557984 174631 None 0 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
10533900 175967 None 8 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL4588454 175967 None 8 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
155544246 173364 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 887 24 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4527484 173364 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 887 24 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155553003 174074 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
CHEMBL4544308 174074 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
155561477 175190 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 811 22 12 11 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4570840 175190 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 811 22 12 11 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155562469 175219 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 29 12 12 -1.1 C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 nan
CHEMBL4571382 175219 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 29 12 12 -1.1 C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 nan
155553930 175439 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4576650 175439 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155551279 173985 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
ChEMBL 877 29 13 12 -2.3 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)CN[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O 10.1021/acs.jmedchem.8b00435
CHEMBL4542269 173985 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
ChEMBL 877 29 13 12 -2.3 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)CN[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O 10.1021/acs.jmedchem.8b00435
3082475 3875 None 16 Human Binding pEC50 = 7.8 7.8 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
6902 3875 None 16 Human Binding pEC50 = 7.8 7.8 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4297447 3875 None 16 Human Binding pEC50 = 7.8 7.8 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
DB12199 3875 None 16 Human Binding pEC50 = 7.8 7.8 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
70538373 175496 None 0 Rat Binding pEC50 = 7.8 7.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 840 23 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C nan
CHEMBL4577691 175496 None 0 Rat Binding pEC50 = 7.8 7.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 840 23 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C nan
155554865 174352 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4551317 174352 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
54726671 94621 None 0 Bovine Binding pEC50 = 5.8 5.8 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 471 5 2 6 5.3 O=c1c(-c2ccccc2)c(O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81134-3
CHEMBL25226 94621 None 0 Bovine Binding pEC50 = 5.8 5.8 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 471 5 2 6 5.3 O=c1c(-c2ccccc2)c(O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81134-3
155560095 174920 None 0 Rat Binding pEC50 = 7.8 7.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 26 14 13 -2.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4564950 174920 None 0 Rat Binding pEC50 = 7.8 7.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 26 14 13 -2.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155563538 175298 None 0 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
CHEMBL4573250 175298 None 0 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
155565687 175581 None 0 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4579604 175581 None 0 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155556507 174484 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4554466 174484 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
54726670 93962 None 0 Bovine Binding pEC50 = 5.8 5.8 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 491 7 2 5 6.2 CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/S0960-894X(01)81134-3
CHEMBL24842 93962 None 0 Bovine Binding pEC50 = 5.8 5.8 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 491 7 2 5 6.2 CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/S0960-894X(01)81134-3
155560463 175038 None 0 Rat Binding pEC50 = 7.7 7.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
CHEMBL4567667 175038 None 0 Rat Binding pEC50 = 7.7 7.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
155553003 174074 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
CHEMBL4544308 174074 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
155554865 174352 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4551317 174352 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155564502 175258 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4572408 175258 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155560463 175038 None 0 Human Binding pEC50 = 7.7 7.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
CHEMBL4567667 175038 None 0 Human Binding pEC50 = 7.7 7.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
155551762 174008 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 26 13 12 -2.2 CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4542709 174008 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 26 13 12 -2.2 CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155552995 174110 None 0 Rat Binding pEC50 = 6.7 6.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 27 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4545399 174110 None 0 Rat Binding pEC50 = 6.7 6.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 27 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155556530 174509 None 0 Rat Binding pEC50 = 6.7 6.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
CHEMBL4555119 174509 None 0 Rat Binding pEC50 = 6.7 6.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
155568109 176037 None 0 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -2.0 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4590381 176037 None 0 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -2.0 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL2392353 210412 None 6 Human Binding pEC50 = 7.7 7.7 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155556530 174509 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
CHEMBL4555119 174509 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
11944 3874 None 0 Human Binding pEC50 = 5.7 5.7 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155552190 3874 None 0 Human Binding pEC50 = 5.7 5.7 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4544228 3874 None 0 Human Binding pEC50 = 5.7 5.7 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155540470 172474 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.3 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4482867 172474 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.3 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155553311 174131 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4546162 174131 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
154573825 175987 None 9 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
CHEMBL4588946 175987 None 9 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
54726676 99225 None 0 Bovine Binding pEC50 = 5.7 5.7 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 501 6 2 7 5.3 COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
CHEMBL28162 99225 None 0 Bovine Binding pEC50 = 5.7 5.7 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 501 6 2 7 5.3 COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
155540328 172899 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
CHEMBL4516066 172899 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
155547428 173613 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4533618 173613 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155568318 176100 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4591448 176100 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155559827 174913 None 0 Rat Binding pEC50 = 7.6 7.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 970 27 13 14 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4564617 174913 None 0 Rat Binding pEC50 = 7.6 7.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 970 27 13 14 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155565112 175497 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1081 26 13 12 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4577692 175497 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1081 26 13 12 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155558784 174774 None 0 Rat Binding pEC50 = 5.6 5.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4561366 174774 None 0 Rat Binding pEC50 = 5.6 5.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155540639 172931 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4516768 172931 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155553479 174176 None 0 Rat Binding pEC50 = 7.6 7.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4547423 174176 None 0 Rat Binding pEC50 = 7.6 7.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155558428 174727 None 0 Rat Binding pEC50 = 7.6 7.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4560224 174727 None 0 Rat Binding pEC50 = 7.6 7.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155553479 174176 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4547423 174176 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155543972 175013 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 13 12 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4567103 175013 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 13 12 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155567790 176051 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 877 24 13 12 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4590589 176051 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 877 24 13 12 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155556507 174484 None 0 Rat Binding pEC50 = 5.6 5.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4554466 174484 None 0 Rat Binding pEC50 = 5.6 5.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
130762 98245 None 9 Bovine Binding pEC50 = 5.6 5.6 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81134-3
CHEMBL274447 98245 None 9 Bovine Binding pEC50 = 5.6 5.6 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81134-3
155568109 176037 None 0 Rat Binding pEC50 = 5.6 5.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -2.0 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4590381 176037 None 0 Rat Binding pEC50 = 5.6 5.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -2.0 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL77838 215876 None 5 Human Binding pEC50 = 8.5 8.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O nan
155558428 174727 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4560224 174727 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155560095 174920 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 26 14 13 -2.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4564950 174920 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 26 14 13 -2.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155548506 173752 None 0 Rat Binding pEC50 = 7.5 7.5 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 13 12 -1.9 CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
CHEMBL4536886 173752 None 0 Rat Binding pEC50 = 7.5 7.5 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 13 12 -1.9 CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
155569246 176181 None 0 Rat Binding pEC50 = 7.5 7.5 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 869 25 13 12 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4593310 176181 None 0 Rat Binding pEC50 = 7.5 7.5 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 869 25 13 12 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155568804 176118 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4591857 176118 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155568318 176100 None 0 Rat Binding pEC50 = 7.5 7.5 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4591448 176100 None 0 Rat Binding pEC50 = 7.5 7.5 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155543091 173178 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4522246 173178 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155550799 174272 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4549405 174272 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155540639 172931 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4516768 172931 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155544988 173440 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 853 24 12 11 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O nan
CHEMBL4529051 173440 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 853 24 12 11 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O nan
155565687 175581 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4579604 175581 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
1610 2345 None 95 Bovine Binding pEC50 = 6.5 6.5 - 4
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
3941 2345 None 95 Bovine Binding pEC50 = 6.5 6.5 - 4
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
3961 2345 None 95 Bovine Binding pEC50 = 6.5 6.5 - 4
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
590 2345 None 95 Bovine Binding pEC50 = 6.5 6.5 - 4
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
CHEMBL191 2345 None 95 Bovine Binding pEC50 = 6.5 6.5 - 4
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
DB00678 2345 None 95 Bovine Binding pEC50 = 6.5 6.5 - 4
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
155563973 175359 None 0 Rat Binding pEC50 = 5.4 5.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 941 27 14 13 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4574655 175359 None 0 Rat Binding pEC50 = 5.4 5.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 941 27 14 13 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155541295 173009 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4518318 173009 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
145925550 175470 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 903 24 13 12 -2.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4577270 175470 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 903 24 13 12 -2.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155539838 172893 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4515848 172893 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
11943 3873 None 0 Rat Binding pEC50 = 7.4 7.4 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
145925549 3873 None 0 Rat Binding pEC50 = 7.4 7.4 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4438122 3873 None 0 Rat Binding pEC50 = 7.4 7.4 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155540033 172888 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
CHEMBL4515768 172888 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
155520014 173234 None 0 Rat Binding pEC50 = 5.4 5.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 27 14 13 -1.9 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4524300 173234 None 0 Rat Binding pEC50 = 5.4 5.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 27 14 13 -1.9 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL312754 211108 None 18 Rat Binding pEC50 = 8.3 8.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155548506 173752 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 13 12 -1.9 CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
CHEMBL4536886 173752 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 13 12 -1.9 CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
155548148 173713 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 943 26 14 14 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4535997 173713 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 943 26 14 14 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155554529 174631 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4557984 174631 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155566196 175744 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4583284 175744 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155558003 174691 None 0 Rat Binding pEC50 = 5.4 5.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4559421 174691 None 0 Rat Binding pEC50 = 5.4 5.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
70538373 175496 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 840 23 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C nan
CHEMBL4577691 175496 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 840 23 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C nan
154573825 175987 None 9 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
CHEMBL4588946 175987 None 9 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
155561477 175190 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 811 22 12 11 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4570840 175190 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 811 22 12 11 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155559104 174804 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4562270 174804 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155552475 174050 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4543860 174050 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155560024 174888 None 0 Rat Binding pEC50 = 4.4 4.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 782 21 11 10 -1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4564094 174888 None 0 Rat Binding pEC50 = 4.4 4.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 782 21 11 10 -1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
11943 3873 None 0 Human Binding pEC50 = 7.4 7.4 - 1
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00435
145925549 3873 None 0 Human Binding pEC50 = 7.4 7.4 - 1
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00435
CHEMBL4438122 3873 None 0 Human Binding pEC50 = 7.4 7.4 - 1
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00435
11943 3873 None 0 Human Binding pEC50 = 7.4 7.4 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
145925549 3873 None 0 Human Binding pEC50 = 7.4 7.4 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4438122 3873 None 0 Human Binding pEC50 = 7.4 7.4 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155542907 173175 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
CHEMBL4522038 173175 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
155541125 172963 None 0 Human Binding pEC50 = 6.4 6.4 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
CHEMBL4517561 172963 None 0 Human Binding pEC50 = 6.4 6.4 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
155552475 174050 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4543860 174050 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155561376 175673 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O nan
CHEMBL4581718 175673 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O nan
155560024 174888 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 782 21 11 10 -1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4564094 174888 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 782 21 11 10 -1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155553098 174108 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4545153 174108 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155553311 174131 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4546162 174131 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155540547 172519 None 0 Rat Binding pEC50 = 8.3 8.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 13 -2.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4483576 172519 None 0 Rat Binding pEC50 = 8.3 8.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 13 -2.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155548148 173713 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 943 26 14 14 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4535997 173713 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 943 26 14 14 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155551762 174008 None 0 Rat Binding pEC50 = 7.3 7.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 26 13 12 -2.2 CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4542709 174008 None 0 Rat Binding pEC50 = 7.3 7.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 26 13 12 -2.2 CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155546362 173549 None 0 Rat Binding pEC50 = 6.3 6.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 26 12 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4532075 173549 None 0 Rat Binding pEC50 = 6.3 6.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 26 12 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155553930 175439 None 0 Rat Binding pEC50 = 6.3 6.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4576650 175439 None 0 Rat Binding pEC50 = 6.3 6.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
54726675 99372 None 0 Bovine Binding pEC50 = 6.3 6.3 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 515 7 2 7 5.7 CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
CHEMBL282566 99372 None 0 Bovine Binding pEC50 = 6.3 6.3 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 515 7 2 7 5.7 CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
155558003 174691 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4559421 174691 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
86727577 115974 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)
ChEMBL 422 2 1 5 3.6 C[C@H]1CN(C)CC[C@H]1c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12 10.1021/jm5013006
CHEMBL3355127 115974 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)
ChEMBL 422 2 1 5 3.6 C[C@H]1CN(C)CC[C@H]1c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12 10.1021/jm5013006
155555310 174357 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 931 25 13 12 -2.2 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4551431 174357 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 931 25 13 12 -2.2 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155555310 174357 None 0 Rat Binding pEC50 = 6.3 6.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 931 25 13 12 -2.2 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4551431 174357 None 0 Rat Binding pEC50 = 6.3 6.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 931 25 13 12 -2.2 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
10533900 175967 None 8 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL4588454 175967 None 8 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
90219582 115975 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)
ChEMBL 436 2 1 5 3.9 Cc1ccc(-c2cc3c(cc2[C@@H]2CCN(C)C[C@@H]2C)N2C(=NNC(=O)[C@H]2C)CO3)c(F)c1 10.1021/jm5013006
CHEMBL3355137 115975 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)
ChEMBL 436 2 1 5 3.9 Cc1ccc(-c2cc3c(cc2[C@@H]2CCN(C)C[C@@H]2C)N2C(=NNC(=O)[C@H]2C)CO3)c(F)c1 10.1021/jm5013006
155552995 174110 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 27 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4545399 174110 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 27 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL77838 215876 None 5 Rat Binding pEC50 = 8.2 8.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O nan
16133225 419 None 52 Rat Binding pEC50 = 8.2 8.2 - 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
172198 419 None 52 Rat Binding pEC50 = 8.2 8.2 - 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
2504 419 None 52 Rat Binding pEC50 = 8.2 8.2 - 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
45266664 419 None 52 Rat Binding pEC50 = 8.2 8.2 - 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
5272 419 None 52 Rat Binding pEC50 = 8.2 8.2 - 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL408403 419 None 52 Rat Binding pEC50 = 8.2 8.2 - 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
DB11842 419 None 52 Rat Binding pEC50 = 8.2 8.2 - 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
54726672 99305 None 0 Bovine Binding pEC50 = 6.2 6.2 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 517 6 2 7 6.0 CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
CHEMBL282082 99305 None 0 Bovine Binding pEC50 = 6.2 6.2 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 517 6 2 7 6.0 CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
54726668 97243 None 0 Bovine Binding pEC50 = 5.2 5.2 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 477 5 2 7 5.3 O=c1c(-c2ccccc2)c(O)c2sccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81134-3
CHEMBL26875 97243 None 0 Bovine Binding pEC50 = 5.2 5.2 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 477 5 2 7 5.3 O=c1c(-c2ccccc2)c(O)c2sccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81134-3
155559827 174913 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 970 27 13 14 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4564617 174913 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 970 27 13 14 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155539838 172893 None 0 Rat Binding pEC50 = 7.2 7.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4515848 172893 None 0 Rat Binding pEC50 = 7.2 7.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155547844 173696 None 0 Rat Binding pEC50 = 7.2 7.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 942 26 14 13 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4535678 173696 None 0 Rat Binding pEC50 = 7.2 7.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 942 26 14 13 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155553098 174108 None 0 Rat Binding pEC50 = 7.2 7.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4545153 174108 None 0 Rat Binding pEC50 = 7.2 7.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155566196 175744 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4583284 175744 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155567790 176051 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 877 24 13 12 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4590589 176051 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 877 24 13 12 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155562469 175219 None 0 Rat Binding pEC50 = 6.2 6.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 29 12 12 -1.1 C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 nan
CHEMBL4571382 175219 None 0 Rat Binding pEC50 = 6.2 6.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 29 12 12 -1.1 C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 nan
155568289 176125 None 0 Rat Binding pEC50 = 6.2 6.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 898 26 11 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4592000 176125 None 0 Rat Binding pEC50 = 6.2 6.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 898 26 11 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155544246 173364 None 0 Rat Binding pEC50 = 6.2 6.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 887 24 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4527484 173364 None 0 Rat Binding pEC50 = 6.2 6.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 887 24 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155520024 173244 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 27 13 12 -1.6 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4524570 173244 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 27 13 12 -1.6 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155558784 174774 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4561366 174774 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155543972 175013 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 13 12 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4567103 175013 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 13 12 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL938 215905 None 28 Rat Binding pEC50 = 8.1 8.1 - 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
155552886 174094 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 13 -2.3 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4544902 174094 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 13 -2.3 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155552886 174094 None 0 Rat Binding pEC50 = 8.1 8.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 13 -2.3 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4544902 174094 None 0 Rat Binding pEC50 = 8.1 8.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 13 -2.3 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
145925550 175470 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 903 24 13 12 -2.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4577270 175470 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 903 24 13 12 -2.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155559104 174804 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4562270 174804 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155541240 173014 None 0 Rat Binding pEC50 = 7.1 7.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 928 26 12 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4518420 173014 None 0 Rat Binding pEC50 = 7.1 7.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 928 26 12 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL2028943 209133 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155552429 174155 None 0 Rat Binding pEC50 = 8.1 8.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4546799 174155 None 0 Rat Binding pEC50 = 8.1 8.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155540328 172899 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
CHEMBL4516066 172899 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
155563676 175342 None 0 Rat Binding pEC50 = 6.1 6.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4574199 175342 None 0 Rat Binding pEC50 = 6.1 6.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155559120 174784 None 0 Rat Binding pEC50 = 6.1 6.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -1.8 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4561769 174784 None 0 Rat Binding pEC50 = 6.1 6.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -1.8 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL2370909 209946 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155552429 174155 None 0 Human Binding pEC50 = 8.0 8.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4546799 174155 None 0 Human Binding pEC50 = 8.0 8.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL312754 211108 None 18 Human Binding pEC50 = 8.0 8.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155541440 173017 None 0 Rat Binding pEC50 = 8.0 8.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
CHEMBL4518530 173017 None 0 Rat Binding pEC50 = 8.0 8.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
16133225 419 None 52 Human Binding pEC50 = 8.0 8.0 -1 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
172198 419 None 52 Human Binding pEC50 = 8.0 8.0 -1 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
2504 419 None 52 Human Binding pEC50 = 8.0 8.0 -1 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
45266664 419 None 52 Human Binding pEC50 = 8.0 8.0 -1 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
5272 419 None 52 Human Binding pEC50 = 8.0 8.0 -1 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL408403 419 None 52 Human Binding pEC50 = 8.0 8.0 -1 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
DB11842 419 None 52 Human Binding pEC50 = 8.0 8.0 -1 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
54726674 99728 None 0 Bovine Binding pEC50 = 7.1 7.1 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 505 6 2 7 5.9 CCc1cc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2s1 10.1016/S0960-894X(01)81134-3
CHEMBL284877 99728 None 0 Bovine Binding pEC50 = 7.1 7.1 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 505 6 2 7 5.9 CCc1cc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2s1 10.1016/S0960-894X(01)81134-3
11944 3874 None 0 Rat Binding pEC50 = 6.0 6.0 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155552190 3874 None 0 Rat Binding pEC50 = 6.0 6.0 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4544228 3874 None 0 Rat Binding pEC50 = 6.0 6.0 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155558059 174681 None 0 Human Binding pEC50 = 6.0 6.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
CHEMBL4559239 174681 None 0 Human Binding pEC50 = 6.0 6.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
155569246 176181 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 869 25 13 12 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4593310 176181 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 869 25 13 12 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
54726673 99221 None 0 Bovine Binding pEC50 = 5.0 5.0 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 477 6 2 5 5.8 COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/S0960-894X(01)81134-3
CHEMBL28160 99221 None 0 Bovine Binding pEC50 = 5.0 5.0 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 477 6 2 5 5.8 COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/S0960-894X(01)81134-3
10032858 29759 None 0 Rabbit Binding pIC50 = 10.4 10.4 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL138690 29759 None 0 Rabbit Binding pIC50 = 10.4 10.4 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1007/s00044-013-0831-x
10032858 29759 None 0 Rabbit Binding pIC50 = 10.4 10.4 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00052a006
CHEMBL138690 29759 None 0 Rabbit Binding pIC50 = 10.4 10.4 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00052a006
9895212 119638 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 614 9 1 6 7.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL346728 119638 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 614 9 1 6 7.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9504722
10417251 96903 None 0 Rabbit Binding pIC50 = 10.3 10.3 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL265797 96903 None 0 Rabbit Binding pIC50 = 10.3 10.3 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10417251 96903 None 0 Rabbit Binding pIC50 = 10.3 10.3 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL265797 96903 None 0 Rabbit Binding pIC50 = 10.3 10.3 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
10417251 96903 None 0 Rabbit Binding pIC50 = 10.3 10.3 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL265797 96903 None 0 Rabbit Binding pIC50 = 10.3 10.3 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10349732 118751 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1007/s00044-013-0831-x
CHEMBL341828 118751 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1007/s00044-013-0831-x
10032820 117302 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
CHEMBL339672 117302 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
10032820 117302 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 117302 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10349732 118751 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL341828 118751 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1021/jm00052a006
10032820 117302 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
CHEMBL339672 117302 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
10439848 119208 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL343309 119208 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10439848 119208 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343309 119208 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10010071 117347 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL339722 117347 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
9829012 92554 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL24322 92554 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
44311455 102742 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 782 17 1 9 8.2 CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL305017 102742 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 782 17 1 9 8.2 CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311580 102777 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 706 16 2 9 6.9 CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL305238 102777 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 706 16 2 9 6.9 CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311676 103059 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 706 17 2 9 7.0 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL307318 103059 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 706 17 2 9 7.0 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311435 204020 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 693 17 1 9 7.3 CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL69721 204020 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 693 17 1 9 7.3 CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311415 204083 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 705 17 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70161 204083 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 705 17 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311434 204122 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 707 18 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70370 204122 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 707 18 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311072 204184 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 679 15 1 9 7.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70789 204184 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 679 15 1 9 7.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311073 204198 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 746 16 1 10 6.6 CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70843 204198 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 746 16 1 10 6.6 CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311414 204221 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 677 15 1 9 6.8 CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70935 204221 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 677 15 1 9 6.8 CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
9829012 92554 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL24322 92554 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
73347893 92624 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435828 92624 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
9829012 92554 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL24322 92554 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
19754061 102732 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 657 15 2 7 7.7 CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
CHEMBL304947 102732 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 657 15 2 7 7.7 CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
44309719 203852 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 544 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68638 203852 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 544 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
10010071 117347 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 117347 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9829012 92554 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL24322 92554 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
9829012 92554 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm058225d
CHEMBL24322 92554 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm058225d
9809961 107159 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL316300 107159 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10439862 118770 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL341934 118770 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10010195 119182 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL343142 119182 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
9809961 107159 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL316300 107159 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
9917295 102956 None 17 Rabbit Binding pIC50 = 10.0 10.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 633 15 2 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL306407 102956 None 17 Rabbit Binding pIC50 = 10.0 10.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 633 15 2 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 10.1016/S0960-894X(01)81115-X
9809961 107159 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00043a020
CHEMBL316300 107159 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00043a020
9809961 107159 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL316300 107159 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10439862 118770 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341934 118770 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10010195 119182 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343142 119182 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10395394 31878 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL140708 31878 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10032851 16833 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL124771 16833 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
9809637 203850 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 643 15 2 7 7.4 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68618 203850 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 643 15 2 7 7.4 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
10032851 16833 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 16833 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10395394 31878 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL140708 31878 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44210588 120343 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 633 12 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353037 120343 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 633 12 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10032851 16833 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL124771 16833 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10327309 113889 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1007/s00044-011-9815-x
CHEMBL332576 113889 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1007/s00044-011-9815-x
10395335 117080 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
CHEMBL339256 117080 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
10372451 117292 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL339605 117292 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10327309 113889 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
CHEMBL332576 113889 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
10395335 117080 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 117080 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10372451 117292 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 117292 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10372093 112760 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 10.1021/jm00043a020
CHEMBL330533 112760 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 10.1021/jm00043a020
44314822 102947 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 102947 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10259411 30656 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL139452 30656 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10485116 116851 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-013-0831-x
CHEMBL338101 116851 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-013-0831-x
10462598 114134 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1007/s00044-011-9815-x
CHEMBL332909 114134 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1007/s00044-011-9815-x
10485116 116851 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338101 116851 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-011-9815-x
10395076 168574 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL435811 168574 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10462598 114134 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 114134 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10485116 116851 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
CHEMBL338101 116851 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
10395076 168574 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 168574 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10395076 168574 None 0 Human Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 168574 None 0 Human Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259411 30656 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139452 30656 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10485116 116851 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL338101 116851 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
10462598 114134 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1007/s00044-011-9815-x
CHEMBL332909 114134 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1007/s00044-011-9815-x
10485116 116851 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338101 116851 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-011-9815-x
10395076 168574 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL435811 168574 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
19939453 112389 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 686 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL329679 112389 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 686 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10326797 207572 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 10.1021/jm00043a020
CHEMBL94905 207572 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 10.1021/jm00043a020
44381724 120306 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 651 11 3 7 6.1 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352771 120306 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 651 11 3 7 6.1 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
44381671 120425 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 647 13 3 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353800 120425 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 647 13 3 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10259395 26993 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL136465 26993 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10078663 207785 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-013-0831-x
CHEMBL96075 207785 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-013-0831-x
9853391 116837 None 1 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338027 116837 None 1 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10101608 117027 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL339004 117027 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10078663 207785 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
CHEMBL96075 207785 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
9853391 116837 None 1 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338027 116837 None 1 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101608 117027 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339004 117027 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10009273 107223 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 636 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 10.1021/jm00043a020
CHEMBL316706 107223 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 636 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 10.1021/jm00043a020
10259395 26993 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL136465 26993 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10078663 207785 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL96075 207785 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
44327716 107312 None 0 Rat Binding pIC50 = 9.8 9.8 - 0
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 492 10 2 5 6.1 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1Cl 10.1016/S0960-894X(01)81116-1
CHEMBL317343 107312 None 0 Rat Binding pIC50 = 9.8 9.8 - 0
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 492 10 2 5 6.1 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1Cl 10.1016/S0960-894X(01)81116-1
9853391 116837 None 1 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338027 116837 None 1 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10101608 117027 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL339004 117027 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10101284 207400 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL93907 207400 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10372659 118088 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL340632 118088 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10101284 207400 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-011-9815-x
CHEMBL93907 207400 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-011-9815-x
54693559 204538 None 2 Human Binding pIC50 = 9.8 9.8 - 0
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
ChEMBL 425 4 2 8 3.0 Cc1nc(C)c2c(O)cc(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 10.1021/jm0204237
CHEMBL72838 204538 None 2 Human Binding pIC50 = 9.8 9.8 - 0
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
ChEMBL 425 4 2 8 3.0 Cc1nc(C)c2c(O)cc(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 10.1021/jm0204237
10101284 207400 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL93907 207400 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
10372659 118088 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL340632 118088 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101284 207400 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
CHEMBL93907 207400 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
10417351 207956 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 706 10 1 8 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL97075 207956 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 706 10 1 8 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 10.1021/jm00043a020
44327912 208133 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 748 12 1 9 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC 10.1021/jm00043a020
CHEMBL98068 208133 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 748 12 1 9 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC 10.1021/jm00043a020
10101284 207400 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL93907 207400 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44381413 120720 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 661 14 3 8 6.6 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL354779 120720 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 661 14 3 8 6.6 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10101284 207400 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-011-9815-x
CHEMBL93907 207400 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-011-9815-x
10372659 118088 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL340632 118088 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10327537 116675 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 719 12 2 8 7.1 CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL337118 116675 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 719 12 2 8 7.1 CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10327537 116675 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 719 12 2 8 7.1 CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL337118 116675 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 719 12 2 8 7.1 CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44210586 59010 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 619 12 3 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169221 59010 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 619 12 3 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
44381527 59072 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169568 59072 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10462933 16880 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL125008 16880 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
76333473 84903 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 771 13 2 8 8.0 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL2236976 84903 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 771 13 2 8 8.0 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10462933 16880 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL125008 16880 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44348523 113177 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL331450 113177 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
10078397 12107 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00043a020
CHEMBL1184032 12107 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00043a020
CHEMBL329290 12107 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00043a020
44315351 104883 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL311160 104883 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
44314823 161884 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL415073 161884 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
44381427 120271 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 632 14 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352503 120271 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 632 14 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10462933 16880 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL125008 16880 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
76333473 84903 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 771 13 2 8 8.0 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL2236976 84903 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 771 13 2 8 8.0 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10439837 16351 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL122917 16351 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10462683 113280 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL331507 113280 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
44311289 102223 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 707 18 1 9 7.7 CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL302964 102223 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 707 18 1 9 7.7 CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311456 102296 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 792 19 1 10 8.6 CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL303427 102296 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 792 19 1 10 8.6 CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311715 103194 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 741 17 1 10 6.7 CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL308323 103194 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 741 17 1 10 6.7 CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311074 104898 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 732 15 1 10 6.2 CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL311253 104898 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 732 15 1 10 6.2 CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311412 105327 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 725 17 1 9 7.1 CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL311625 105327 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 725 17 1 9 7.1 CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311581 167831 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 720 17 2 9 7.3 CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL430792 167831 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 720 17 2 9 7.3 CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311582 204206 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 790 21 1 9 8.5 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70868 204206 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 790 21 1 9 8.5 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
9918412 204260 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 739 16 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL71172 204260 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 739 16 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311413 204349 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 709 17 1 9 8.1 CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL71639 204349 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 709 17 1 9 8.1 CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311753 204609 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 773 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL73283 204609 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 773 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
133031 100857 None 21 Rabbit Binding pIC50 = 9.7 9.7 - 1
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL293511 100857 None 21 Rabbit Binding pIC50 = 9.7 9.7 - 1
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/j.bmc.2010.10.043
19939756 5036 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1
ChEMBL 534 9 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL105199 5036 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1
ChEMBL 534 9 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
133031 100857 None 21 Rabbit Binding pIC50 = 9.7 9.7 - 1
Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00017-0
CHEMBL293511 100857 None 21 Rabbit Binding pIC50 = 9.7 9.7 - 1
Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00017-0
44335530 107507 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1
ChEMBL 520 9 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL318605 107507 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1
ChEMBL 520 9 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
133031 100857 None 21 Rabbit Binding pIC50 = 9.7 9.7 - 1
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00050a002
CHEMBL293511 100857 None 21 Rabbit Binding pIC50 = 9.7 9.7 - 1
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00050a002
10439837 16351 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122917 16351 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
10462683 113280 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331507 113280 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44377058 120004 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 554 16 3 6 5.8 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL350121 120004 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 554 16 3 6 5.8 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
10349512 208005 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 670 11 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97332 208005 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 670 11 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm00043a020
44314761 102852 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305647 102852 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
9853391 116837 None 1 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm9504722
CHEMBL338027 116837 None 1 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm9504722
133031 100857 None 21 Rabbit Binding pIC50 = 9.7 9.7 - 1
Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL293511 100857 None 21 Rabbit Binding pIC50 = 9.7 9.7 - 1
Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
10439837 16351 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL122917 16351 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10462683 113280 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL331507 113280 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10010234 98425 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL275552 98425 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10100951 115042 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-013-0831-x
CHEMBL334300 115042 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-013-0831-x
9987614 168571 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 747 12 2 8 7.9 CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL435792 168571 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 747 12 2 8 7.9 CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10100951 115042 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-011-9815-x
CHEMBL334300 115042 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-011-9815-x
10259468 118479 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL341369 118479 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10390872 116144 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 490 7 1 6 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00050a002
CHEMBL335778 116144 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 490 7 1 6 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00050a002
10100951 115042 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL334300 115042 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
10259468 118479 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL341369 118479 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
9895635 112021 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 10.1021/jm00043a020
CHEMBL328941 112021 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 10.1021/jm00043a020
10010234 98425 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL275552 98425 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10100951 115042 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL334300 115042 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
9987614 168571 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 747 12 2 8 7.9 CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL435792 168571 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 747 12 2 8 7.9 CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44381402 59163 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 647 12 2 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169967 59163 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 647 12 2 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10100951 115042 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-011-9815-x
CHEMBL334300 115042 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-011-9815-x
10259468 118479 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL341369 118479 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10101606 15769 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL122273 15769 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10259447 16926 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1007/s00044-011-9815-x
CHEMBL125280 16926 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1007/s00044-011-9815-x
10101606 15769 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122273 15769 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10259447 16926 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL125280 16926 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
10326942 112392 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 10.1021/jm00043a020
CHEMBL329693 112392 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 10.1021/jm00043a020
10417102 207444 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 676 10 1 9 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 10.1021/jm00043a020
CHEMBL94145 207444 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 676 10 1 9 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 10.1021/jm00043a020
10101606 15769 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL122273 15769 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10259447 16926 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1007/s00044-011-9815-x
CHEMBL125280 16926 None 0 Rabbit Binding pIC50 = 9.7 9.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1007/s00044-011-9815-x
10033136 16071 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL122380 16071 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10033136 16071 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122380 16071 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
44315078 204754 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74556 204754 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10033136 16071 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL122380 16071 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10009984 113178 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL331455 113178 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1007/s00044-011-9815-x
10440144 116892 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL338342 116892 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10009984 113178 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
CHEMBL331455 113178 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
10440144 116892 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338342 116892 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
15292113 96031 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL259843 96031 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
9895984 204747 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
CHEMBL74476 204747 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
9895984 204747 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1021/jm9504722
CHEMBL74476 204747 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1021/jm9504722
44381657 59056 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169488 59056 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
9895984 204747 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL74476 204747 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10009984 113178 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL331455 113178 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1007/s00044-011-9815-x
10440144 116892 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL338342 116892 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10372497 118744 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 692 11 1 9 6.3 CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL341783 118744 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 692 11 1 9 6.3 CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10259657 119391 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 781 14 2 8 8.1 CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL344597 119391 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 781 14 2 8 8.1 CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10259489 16916 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1007/s00044-011-9815-x
CHEMBL125231 16916 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1007/s00044-011-9815-x
19939418 108268 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 733 13 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL319730 108268 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 733 13 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
10395335 117080 None 0 Human Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 117080 None 0 Human Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10259489 16916 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
CHEMBL125231 16916 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
10372497 118744 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 692 11 1 9 6.3 CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341783 118744 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 692 11 1 9 6.3 CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10259657 119391 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 781 14 2 8 8.1 CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344597 119391 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 781 14 2 8 8.1 CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44210589 58594 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 619 11 3 8 5.4 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168413 58594 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 619 11 3 8 5.4 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
44381403 59164 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 675 11 2 9 5.4 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169968 59164 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 675 11 2 9 5.4 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
44210585 120405 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 647 14 3 8 6.2 CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81126-4
CHEMBL353615 120405 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 647 14 3 8 6.2 CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81126-4
10010207 30193 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 735 13 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL139041 30193 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 735 13 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10078780 116914 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL338433 116914 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10439819 169887 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL444065 169887 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
19754068 102731 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 643 13 2 7 7.2 CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL304946 102731 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 643 13 2 7 7.2 CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C 10.1016/S0960-894X(01)81115-X
10078780 116914 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338433 116914 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10439819 169887 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL444065 169887 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10416475 207702 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 10.1021/jm00043a020
CHEMBL95579 207702 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 10.1021/jm00043a020
10010207 30193 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 735 13 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139041 30193 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 735 13 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44210590 58712 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 605 11 3 8 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168490 58712 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 605 11 3 8 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10439715 117033 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL339040 117033 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
44309938 204298 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 619 14 2 8 6.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL71388 204298 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 619 14 2 8 6.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10028545 21003 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 490 8 1 6 4.9 CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm00050a002
CHEMBL131156 21003 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 490 8 1 6 4.9 CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm00050a002
10439715 117033 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339040 117033 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10055534 157459 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL407919 157459 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 10.1021/jm00043a020
9875044 208027 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 10.1021/jm00043a020
CHEMBL97446 208027 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 10.1021/jm00043a020
10439715 117033 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL339040 117033 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
11765560 15535 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL121872 15535 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
9987414 117047 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL339113 117047 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
19430442 204173 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL70726 204173 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
11765560 15535 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121872 15535 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
9987414 117047 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339113 117047 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10100951 115042 None 0 Human Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL334300 115042 None 0 Human Binding pIC50 = 9.6 9.6 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
11765560 15535 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL121872 15535 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
9987414 117047 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL339113 117047 None 0 Rabbit Binding pIC50 = 9.6 9.6 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
9810305 98570 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-013-0831-x
CHEMBL276674 98570 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-013-0831-x
9810305 98570 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-011-9815-x
CHEMBL276674 98570 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-011-9815-x
9810305 98570 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL276674 98570 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
9810305 98570 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL276674 98570 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
9810305 98570 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL276674 98570 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
9810305 98570 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-011-9815-x
CHEMBL276674 98570 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-011-9815-x
10439993 119254 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 739 13 2 8 8.1 CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL343634 119254 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 739 13 2 8 8.1 CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
183134 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81148-3
CHEMBL7550 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81148-3
44311675 102152 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL302579 102152 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311537 102330 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 726 15 1 9 8.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL303647 102330 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 726 15 1 9 8.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311454 102943 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 692 17 2 8 6.9 CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL306340 102943 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 692 17 2 8 6.9 CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311185 104189 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 733 15 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL309790 104189 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 733 15 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311752 104863 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL311018 104863 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311736 204205 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70867 204205 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311557 204281 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL71286 204281 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 10.1016/S0960-894X(00)80077-3
183134 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL7550 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
183134 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL7550 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
73353934 92620 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 469 9 2 4 6.4 CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
CHEMBL2435824 92620 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 469 9 2 4 6.4 CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
183134 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81119-7
CHEMBL7550 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81119-7
183134 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL7550 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
183134 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00050a002
CHEMBL7550 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00050a002
10326972 112259 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 10.1021/jm00043a020
CHEMBL329099 112259 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 10.1021/jm00043a020
133031 100857 None 21 Rabbit Binding pIC50 = 9.5 9.5 - 1
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL293511 100857 None 21 Rabbit Binding pIC50 = 9.5 9.5 - 1
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
44300826 198736 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 544 7 1 7 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL58291 198736 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 544 7 1 7 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
44372744 52149 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 451 7 1 6 5.5 CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 10.1021/jm9504722
CHEMBL158795 52149 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 451 7 1 6 5.5 CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 10.1021/jm9504722
9807029 203102 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1021/jm9504722
CHEMBL63998 203102 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1021/jm9504722
183134 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a001
CHEMBL7550 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a001
44384389 129835 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 572 2 2 7 5.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 10.1016/0960-894X(96)00116-3
CHEMBL367569 129835 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 572 2 2 7 5.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 10.1016/0960-894X(96)00116-3
183134 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL7550 204842 None 17 Rabbit Binding pIC50 = 9.5 9.5 - 1
Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
10439993 119254 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 739 13 2 8 8.1 CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343634 119254 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 739 13 2 8 8.1 CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
19102786 207187 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 648 9 1 8 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL92533 207187 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 648 9 1 8 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
9939191 98944 None 1 Rat Binding pIC50 = 9.5 9.5 - 1
In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL279629 98944 None 1 Rat Binding pIC50 = 9.5 9.5 - 1
In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL97539 98944 None 1 Rat Binding pIC50 = 9.5 9.5 - 1
In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
10032583 12347 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 10.1021/jm00043a020
CHEMBL1185398 12347 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 10.1021/jm00043a020
CHEMBL411487 12347 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 10.1021/jm00043a020
10054708 107152 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 10.1021/jm00043a020
CHEMBL316273 107152 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 10.1021/jm00043a020
10462598 114134 None 0 Human Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 114134 None 0 Human Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10032820 117302 None 0 Human Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 117302 None 0 Human Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
44381552 120285 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 649 13 3 9 5.0 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352629 120285 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 649 13 3 9 5.0 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 10.1016/S0960-894X(01)81126-4
9917399 102144 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL302519 102144 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
9939191 98944 None 1 Rat Binding pIC50 = 9.5 9.5 - 1
In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL279629 98944 None 1 Rat Binding pIC50 = 9.5 9.5 - 1
In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL97539 98944 None 1 Rat Binding pIC50 = 9.5 9.5 - 1
In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
9917399 102144 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1021/jm9504722
CHEMBL302519 102144 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1021/jm9504722
1610 2345 None 95 Human Binding pIC50 = 9.5 9.5 1 4
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
3941 2345 None 95 Human Binding pIC50 = 9.5 9.5 1 4
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
3961 2345 None 95 Human Binding pIC50 = 9.5 9.5 1 4
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
590 2345 None 95 Human Binding pIC50 = 9.5 9.5 1 4
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
CHEMBL191 2345 None 95 Human Binding pIC50 = 9.5 9.5 1 4
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
DB00678 2345 None 95 Human Binding pIC50 = 9.5 9.5 1 4
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
44381553 120334 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 675 13 2 8 6.8 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352947 120334 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 675 13 2 8 6.8 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
136052288 124482 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 568 8 1 8 5.2 CCc1cc2c(=O)n(CCc3ccc(F)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640122 124482 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 568 8 1 8 5.2 CCc1cc2c(=O)n(CCc3ccc(F)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
10101351 168662 None 0 Human Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL436396 168662 None 0 Human Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
71652854 89154 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 593 11 2 7 5.9 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2337686 89154 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 593 11 2 7 5.9 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2366020 89154 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 593 11 2 7 5.9 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
10101351 168662 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL436396 168662 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
19430462 102982 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 735 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306638 102982 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 735 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL938 215905 None 28 Human Binding pIC50 = 9.5 9.5 1 2
Binding affinity to human AT1 receptor by radioligand displacement assayBinding affinity to human AT1 receptor by radioligand displacement assay
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1016/j.ejmech.2013.01.044
14971698 207291 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneDisplacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membrane
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1039/d2md00206j
CHEMBL93226 207291 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneDisplacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membrane
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1039/d2md00206j
10101351 168662 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL436396 168662 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10032342 208020 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 9 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 10.1021/jm00043a020
CHEMBL97394 208020 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 9 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 10.1021/jm00043a020
44381426 120270 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 666 12 2 8 6.8 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352502 120270 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 666 12 2 8 6.8 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
10101351 168662 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL436396 168662 None 0 Rabbit Binding pIC50 = 9.5 9.5 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10373120 117599 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1007/s00044-011-9815-x
CHEMBL340078 117599 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1007/s00044-011-9815-x
10373120 117599 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL340078 117599 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
19939398 107332 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 10.1021/jm00043a020
CHEMBL317547 107332 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 10.1021/jm00043a020
10372718 108555 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 722 10 1 7 7.4 O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl 10.1021/jm00043a020
CHEMBL320222 108555 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 722 10 1 7 7.4 O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl 10.1021/jm00043a020
10259447 16926 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL125280 16926 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
44381656 120266 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 656 12 2 9 6.4 CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352458 120266 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 656 12 2 9 6.4 CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
10373120 117599 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1007/s00044-011-9815-x
CHEMBL340078 117599 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1007/s00044-011-9815-x
10440203 118985 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 773 13 2 8 8.5 CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL342492 118985 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 773 13 2 8 8.5 CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
11765454 118066 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL340473 118066 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
44310069 203736 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 617 16 2 7 7.0 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL67801 203736 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 617 16 2 7 7.0 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
11765454 118066 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL340473 118066 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10349597 111616 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 680 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 10.1021/jm00043a020
CHEMBL328434 111616 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 680 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 10.1021/jm00043a020
10440203 118985 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 773 13 2 8 8.5 CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL342492 118985 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 773 13 2 8 8.5 CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
11765454 118066 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL340473 118066 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10259525 15617 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL122158 15617 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10349897 114426 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL333224 114426 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10101690 116859 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL338137 116859 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10010071 117347 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 117347 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259525 15617 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122158 15617 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10349897 114426 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL333224 114426 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101690 116859 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338137 116859 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259525 15617 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL122158 15617 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10349897 114426 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL333224 114426 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10101690 116859 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL338137 116859 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
44328276 112725 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 10 1 7 6.5 C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
CHEMBL330464 112725 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 10 1 7 6.5 C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
44381622 59019 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 689 12 2 9 5.8 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169279 59019 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 689 12 2 9 5.8 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
44311619 103068 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 756 16 2 8 8.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL307359 103068 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 756 16 2 8 8.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311683 105616 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 789 16 1 10 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL312301 105616 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 789 16 1 10 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311453 204035 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 678 17 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL69839 204035 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 678 17 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
16133225 419 None 52 Rat Binding pIC50 = 9.4 9.4 -2 4
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL None None None None 10.1021/jm031100t
172198 419 None 52 Rat Binding pIC50 = 9.4 9.4 -2 4
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL None None None None 10.1021/jm031100t
2504 419 None 52 Rat Binding pIC50 = 9.4 9.4 -2 4
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL None None None None 10.1021/jm031100t
45266664 419 None 52 Rat Binding pIC50 = 9.4 9.4 -2 4
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL None None None None 10.1021/jm031100t
5272 419 None 52 Rat Binding pIC50 = 9.4 9.4 -2 4
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL None None None None 10.1021/jm031100t
CHEMBL408403 419 None 52 Rat Binding pIC50 = 9.4 9.4 -2 4
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL None None None None 10.1021/jm031100t
DB11842 419 None 52 Rat Binding pIC50 = 9.4 9.4 -2 4
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL None None None None 10.1021/jm031100t
183134 204842 None 17 Rat Binding pIC50 = 9.4 9.4 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm031100t
CHEMBL7550 204842 None 17 Rat Binding pIC50 = 9.4 9.4 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm031100t
73347892 92619 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 455 8 2 4 6.1 CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435823 92619 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 455 8 2 4 6.1 CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
16133225 419 None 52 Rat Binding pIC50 = 9.4 9.4 - 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL None None None None 10.1021/jm7011563
172198 419 None 52 Rat Binding pIC50 = 9.4 9.4 - 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL None None None None 10.1021/jm7011563
2504 419 None 52 Rat Binding pIC50 = 9.4 9.4 - 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL None None None None 10.1021/jm7011563
45266664 419 None 52 Rat Binding pIC50 = 9.4 9.4 - 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL None None None None 10.1021/jm7011563
5272 419 None 52 Rat Binding pIC50 = 9.4 9.4 - 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL None None None None 10.1021/jm7011563
CHEMBL408403 419 None 52 Rat Binding pIC50 = 9.4 9.4 - 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL None None None None 10.1021/jm7011563
DB11842 419 None 52 Rat Binding pIC50 = 9.4 9.4 - 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL None None None None 10.1021/jm7011563
183134 204842 None 17 Rat Binding pIC50 = 9.4 9.4 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL7550 204842 None 17 Rat Binding pIC50 = 9.4 9.4 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL938 215905 None 28 Human Binding pIC50 = 9.4 9.4 1 2
Displacement of [125I][Sar, Ile]-ATII from human recombinant AT1 receptor expressed in HEK293 cellsDisplacement of [125I][Sar, Ile]-ATII from human recombinant AT1 receptor expressed in HEK293 cells
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1016/j.bmc.2016.03.006
CHEMBL938 215905 None 28 Human Binding pIC50 = 9.4 9.4 1 2
Displacement of [125I][Sar1,Ile8]-AT2 from human recombinant AT1 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [125I][Sar1,Ile8]-AT2 from human recombinant AT1 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1016/j.bmc.2016.11.014
10394995 111392 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 10.1021/jm00043a020
CHEMBL327191 111392 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 10.1021/jm00043a020
10326775 112237 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 10.1021/jm00043a020
CHEMBL329089 112237 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 10.1021/jm00043a020
10010047 207949 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 712 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 10.1021/jm00043a020
CHEMBL97020 207949 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 712 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 10.1021/jm00043a020
10439819 169887 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL444065 169887 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44384870 60044 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 541 8 2 7 5.5 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL173643 60044 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 541 8 2 7 5.5 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(96)00116-3
10010311 30525 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 753 12 2 8 7.8 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL139325 30525 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 753 12 2 8 7.8 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10417144 32978 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 679 11 1 9 6.4 CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL141592 32978 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 679 11 1 9 6.4 CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10462573 117007 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338889 117007 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10032988 116915 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 116915 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10462573 117007 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338889 117007 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10078132 107249 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 10.1021/jm00043a020
CHEMBL316904 107249 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 10.1021/jm00043a020
10010311 30525 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 753 12 2 8 7.8 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139325 30525 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 753 12 2 8 7.8 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10417144 32978 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 679 11 1 9 6.4 CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL141592 32978 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 679 11 1 9 6.4 CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10462573 117007 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338889 117007 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
11765541 119006 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL342605 119006 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10032988 116915 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338434 116915 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10032988 116915 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 116915 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10077743 207955 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1021/jm00043a020
CHEMBL97068 207955 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1021/jm00043a020
11765541 119006 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL342605 119006 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10032988 116915 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338434 116915 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
9939191 98944 None 1 Rabbit Binding pIC50 = 9.4 9.4 - 1
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1007/s00044-013-0831-x
CHEMBL279629 98944 None 1 Rabbit Binding pIC50 = 9.4 9.4 - 1
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1007/s00044-013-0831-x
CHEMBL97539 98944 None 1 Rabbit Binding pIC50 = 9.4 9.4 - 1
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1007/s00044-013-0831-x
9939191 98944 None 1 Rabbit Binding pIC50 = 9.4 9.4 - 1
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL279629 98944 None 1 Rabbit Binding pIC50 = 9.4 9.4 - 1
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL97539 98944 None 1 Rabbit Binding pIC50 = 9.4 9.4 - 1
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
9939191 98944 None 1 Rabbit Binding pIC50 = 9.4 9.4 - 1
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00019a004
CHEMBL279629 98944 None 1 Rabbit Binding pIC50 = 9.4 9.4 - 1
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00019a004
CHEMBL97539 98944 None 1 Rabbit Binding pIC50 = 9.4 9.4 - 1
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00019a004
9939191 98944 None 1 Rabbit Binding pIC50 = 9.4 9.4 - 1
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL279629 98944 None 1 Rabbit Binding pIC50 = 9.4 9.4 - 1
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97539 98944 None 1 Rabbit Binding pIC50 = 9.4 9.4 - 1
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10349659 111541 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 688 10 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 10.1021/jm00043a020
CHEMBL327988 111541 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 688 10 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 10.1021/jm00043a020
10395335 117080 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 117080 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10259468 118479 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL341369 118479 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
9939191 98944 None 1 Rabbit Binding pIC50 = 9.4 9.4 - 1
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00052a006
CHEMBL279629 98944 None 1 Rabbit Binding pIC50 = 9.4 9.4 - 1
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00052a006
CHEMBL97539 98944 None 1 Rabbit Binding pIC50 = 9.4 9.4 - 1
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00052a006
9852499 120461 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 647 11 3 8 6.1 CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL354080 120461 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 647 11 3 8 6.1 CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 10.1016/S0960-894X(01)81126-4
10032877 15547 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL121907 15547 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10259841 16156 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL122401 16156 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
9827346 99735 None 4 Rat Binding pIC50 = 9.4 9.4 - 0
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 10.1016/S0960-894X(96)00250-8
CHEMBL284918 99735 None 4 Rat Binding pIC50 = 9.4 9.4 - 0
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 10.1016/S0960-894X(96)00250-8
CHEMBL34866 99735 None 4 Rat Binding pIC50 = 9.4 9.4 - 0
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 10.1016/S0960-894X(96)00250-8
10032877 15547 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121907 15547 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10259841 16156 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122401 16156 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10372451 117292 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 117292 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10032877 15547 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL121907 15547 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10259841 16156 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL122401 16156 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
9830680 100641 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 1
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-013-0831-x
CHEMBL292150 100641 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 1
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-013-0831-x
9830680 100641 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 1
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL292150 100641 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 1
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
9830680 100641 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 1
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL292150 100641 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 1
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00043a020
10009984 113178 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
CHEMBL331455 113178 None 0 Human Binding pIC50 = 9.4 9.4 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
9830680 100641 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 1
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm9504722
CHEMBL292150 100641 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 1
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm9504722
9830680 100641 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 1
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL292150 100641 None 0 Rabbit Binding pIC50 = 9.4 9.4 - 1
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
44312565 204769 None 0 Human Binding pIC50 = 9.3 9.3 - 1
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
ChEMBL 437 9 3 6 3.1 CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C 10.1021/jm0204237
CHEMBL74767 204769 None 0 Human Binding pIC50 = 9.3 9.3 - 1
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
ChEMBL 437 9 3 6 3.1 CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C 10.1021/jm0204237
44348153 117968 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 10.1021/jm00075a033
CHEMBL340367 117968 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 10.1021/jm00075a033
72548703 161565 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor after 120 mins by scintillation counting analysisDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor after 120 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
CHEMBL4128926 161565 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor after 120 mins by scintillation counting analysisDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor after 120 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
10009968 112545 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 10.1021/jm00043a020
CHEMBL329942 112545 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 10.1021/jm00043a020
2583 3774 None 118 Human Binding pIC50 = 9.3 9.3 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmcl.2012.11.088
592 3774 None 118 Human Binding pIC50 = 9.3 9.3 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmcl.2012.11.088
65999 3774 None 118 Human Binding pIC50 = 9.3 9.3 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmcl.2012.11.088
CHEMBL1017 3774 None 118 Human Binding pIC50 = 9.3 9.3 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmcl.2012.11.088
DB00966 3774 None 118 Human Binding pIC50 = 9.3 9.3 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmcl.2012.11.088
2583 3774 None 118 Human Binding pIC50 = 9.3 9.3 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1021/jm200409s
592 3774 None 118 Human Binding pIC50 = 9.3 9.3 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1021/jm200409s
65999 3774 None 118 Human Binding pIC50 = 9.3 9.3 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1021/jm200409s
CHEMBL1017 3774 None 118 Human Binding pIC50 = 9.3 9.3 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1021/jm200409s
DB00966 3774 None 118 Human Binding pIC50 = 9.3 9.3 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1021/jm200409s
10480309 16376 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 480 13 1 5 5.2 CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL122969 16376 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 480 13 1 5 5.2 CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
10007362 17315 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 536 12 2 8 4.6 CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL125725 17315 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 536 12 2 8 4.6 CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
44311182 103025 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL307008 103025 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311452 204503 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 739 15 1 9 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL72595 204503 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 739 15 1 9 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
9940350 204756 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74573 204756 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44275095 95175 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 536 9 3 7 5.2 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL25585 95175 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 536 9 3 7 5.2 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
44309704 204276 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 612 13 1 7 7.7 CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
CHEMBL71253 204276 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 612 13 1 7 7.7 CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
183134 204842 None 17 Rabbit Binding pIC50 = 9.3 9.3 - 1
In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80044-X
CHEMBL7550 204842 None 17 Rabbit Binding pIC50 = 9.3 9.3 - 1
In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80044-X
9939191 98944 None 1 Rabbit Binding pIC50 = 9.3 9.3 - 1
In vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit adrenal tissue preparationIn vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL279629 98944 None 1 Rabbit Binding pIC50 = 9.3 9.3 - 1
In vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit adrenal tissue preparationIn vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL97539 98944 None 1 Rabbit Binding pIC50 = 9.3 9.3 - 1
In vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit adrenal tissue preparationIn vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
44379268 120052 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 666 11 1 8 6.4 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL350554 120052 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 666 11 1 8 6.4 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
44377125 55637 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 545 10 1 7 5.0 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL162148 55637 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 545 10 1 7 5.0 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
10032851 16833 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 16833 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
11765177 117006 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338888 117006 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
19939753 203752 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 605 13 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL67921 203752 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 605 13 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
11765177 117006 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338888 117006 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
11765177 117006 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338888 117006 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
44315144 96590 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL263191 96590 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10439858 16859 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL124903 16859 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
18950609 16403 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl 10.1021/jm00075a033
CHEMBL123084 16403 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl 10.1021/jm00075a033
10439858 16859 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL124903 16859 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439858 16859 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL124903 16859 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
183134 204842 None 17 Rabbit Binding pIC50 = 9.3 9.3 - 1
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a033
CHEMBL7550 204842 None 17 Rabbit Binding pIC50 = 9.3 9.3 - 1
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a033
44315282 96622 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
CHEMBL263452 96622 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
14971639 114130 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneDisplacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membrane
ChEMBL 512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1039/d2md00206j
CHEMBL332897 114130 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneDisplacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membrane
ChEMBL 512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1039/d2md00206j
9939191 98944 None 1 Rabbit Binding pIC50 = 9.3 9.3 - 1
In vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit brain tissue preparationIn vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL279629 98944 None 1 Rabbit Binding pIC50 = 9.3 9.3 - 1
In vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit brain tissue preparationIn vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL97539 98944 None 1 Rabbit Binding pIC50 = 9.3 9.3 - 1
In vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit brain tissue preparationIn vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
10101608 117027 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339004 117027 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
44381425 120452 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 681 12 3 8 7.2 CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353980 120452 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 681 12 3 8 7.2 CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
10032193 119143 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 649 10 2 8 6.1 CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL342843 119143 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 649 10 2 8 6.1 CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10394829 119358 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 683 10 2 8 6.5 CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL344387 119358 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 683 10 2 8 6.5 CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10417321 15616 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL122157 15616 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10417321 15616 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122157 15616 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10438745 107214 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 10.1021/jm00043a020
CHEMBL316655 107214 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 10.1021/jm00043a020
10258694 112585 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 10.1021/jm00043a020
CHEMBL330165 112585 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 10.1021/jm00043a020
10010071 117347 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 117347 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10032193 119143 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 649 10 2 8 6.1 CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL342843 119143 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 649 10 2 8 6.1 CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10394829 119358 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 683 10 2 8 6.5 CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344387 119358 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 683 10 2 8 6.5 CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10417321 15616 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL122157 15616 None 0 Rabbit Binding pIC50 = 9.3 9.3 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
19430475 204250 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 787 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL71125 204250 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 787 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F 10.1016/S0960-894X(00)80077-3
9874508 204678 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL73876 204678 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
9874508 204678 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1021/jm9504722
CHEMBL73876 204678 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1021/jm9504722
CHEMBL938 215905 None 28 Human Binding pIC50 = 9.2 9.2 1 2
Inhibition of human angiotensin II AT1 receptorInhibition of human angiotensin II AT1 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1016/j.bmc.2010.07.034
44274855 96940 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 564 9 1 7 5.5 CCCCc1nc2ccc(N(C)C(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL26614 96940 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 564 9 1 7 5.5 CCCCc1nc2ccc(N(C)C(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
9960852 107180 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 12 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
CHEMBL316482 107180 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 12 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
10030110 16248 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 536 12 2 8 4.6 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL122443 16248 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 536 12 2 8 4.6 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
10256602 16864 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 534 12 1 6 5.9 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)s2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL124925 16864 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 534 12 1 6 5.9 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)s2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
10052399 118466 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 520 12 1 6 5.6 CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL341295 118466 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 520 12 1 6 5.6 CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
44311617 102537 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 679 13 1 9 6.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL304065 102537 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 679 13 1 9 6.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 10.1016/S0960-894X(00)80077-3
44311618 163335 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 772 16 2 8 7.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL419073 163335 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 772 16 2 8 7.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
19430479 204267 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL71220 204267 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311184 204419 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 727 16 1 9 8.6 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL72099 204419 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 727 16 1 9 8.6 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311558 204720 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74236 204720 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL938 215905 None 28 Human Binding pIC50 = 9.2 9.2 1 2
Binding affinity to human angiotensin AT1 receptor by radioligand displacement assayBinding affinity to human angiotensin AT1 receptor by radioligand displacement assay
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1016/j.bmc.2013.03.016
44309902 103115 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 598 12 1 7 7.4 CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL307757 103115 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 598 12 1 7 7.4 CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
44309703 172552 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL448476 172552 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
44309903 204392 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL71925 204392 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
10010027 208030 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 710 11 1 7 7.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97465 208030 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 710 11 1 7 7.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 10.1021/jm00043a020
44309903 204392 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL71925 204392 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
10372810 106200 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL313868 106200 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
15292111 204743 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74442 204743 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10485202 119418 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 747 14 1 8 7.4 CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL344811 119418 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 747 14 1 8 7.4 CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10485202 119418 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 747 14 1 8 7.4 CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344811 119418 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 747 14 1 8 7.4 CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
1952 2207 None 4 Rabbit Binding pIC50 = 9.2 9.2 - 2
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F 10.1021/jm00043a020
5312129 2207 None 4 Rabbit Binding pIC50 = 9.2 9.2 - 2
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F 10.1021/jm00043a020
CHEMBL1182768 2207 None 4 Rabbit Binding pIC50 = 9.2 9.2 - 2
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F 10.1021/jm00043a020
9874086 109111 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 10.1021/jm00043a020
CHEMBL321367 109111 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 10.1021/jm00043a020
10439715 117033 None 0 Human Binding pIC50 = 9.2 9.2 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339040 117033 None 0 Human Binding pIC50 = 9.2 9.2 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10457566 202800 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 473 8 1 8 1.9 CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL62269 202800 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 473 8 1 8 1.9 CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
44282952 120427 None 0 Rat Binding pIC50 = 9.2 9.2 - 1
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 511 7 2 8 3.8 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 10.1016/S0960-894X(96)00250-8
CHEMBL35381 120427 None 0 Rat Binding pIC50 = 9.2 9.2 - 1
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 511 7 2 8 3.8 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 10.1016/S0960-894X(96)00250-8
CHEMBL938 215905 None 28 Human Binding pIC50 = 9.2 9.2 1 2
Displacement of radiolabeled saralasin from human AT1 receptorDisplacement of radiolabeled saralasin from human AT1 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm8007618
10350378 208197 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 796 10 1 8 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 10.1021/jm00043a020
CHEMBL98453 208197 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 796 10 1 8 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 10.1021/jm00043a020
10028460 116519 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 488 7 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00050a002
CHEMBL336180 116519 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 488 7 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00050a002
10009478 112470 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1021/jm00043a020
CHEMBL329858 112470 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1021/jm00043a020
2541 785 None 120 Human Binding pIC50 = 9.2 9.2 -1 6
Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
587 785 None 120 Human Binding pIC50 = 9.2 9.2 -1 6
Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
6907 785 None 120 Human Binding pIC50 = 9.2 9.2 -1 6
Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL1016 785 None 120 Human Binding pIC50 = 9.2 9.2 -1 6
Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
DB00796 785 None 120 Human Binding pIC50 = 9.2 9.2 -1 6
Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
DB13919 785 None 120 Human Binding pIC50 = 9.2 9.2 -1 6
Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
10414338 17962 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 520 12 1 6 5.6 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL126111 17962 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 520 12 1 6 5.6 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
9824776 119363 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
ChEMBL 445 5 1 6 4.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL344407 119363 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
ChEMBL 445 5 1 6 4.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 10.1016/j.bmc.2010.10.043
60148656 92625 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 457 7 2 5 5.9 CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435829 92625 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 457 7 2 5 5.9 CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
9824776 119363 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 445 5 1 6 4.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 10.1016/S0960-894X(01)81119-7
CHEMBL344407 119363 None 0 Rabbit Binding pIC50 = 9.2 9.2 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 445 5 1 6 4.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 10.1016/S0960-894X(01)81119-7
15292113 96031 None 0 Human Binding pIC50 = 9.2 9.2 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL259843 96031 None 0 Human Binding pIC50 = 9.2 9.2 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10349801 107936 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 10.1021/jm00043a020
CHEMBL319353 107936 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 10.1021/jm00043a020
10417431 109106 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 718 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 10.1021/jm00043a020
CHEMBL321363 109106 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 718 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 10.1021/jm00043a020
10101606 15769 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122273 15769 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
16133225 419 None 52 Human Binding pIC50 = 9.1 9.1 -1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
172198 419 None 52 Human Binding pIC50 = 9.1 9.1 -1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
2504 419 None 52 Human Binding pIC50 = 9.1 9.1 -1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
45266664 419 None 52 Human Binding pIC50 = 9.1 9.1 -1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5272 419 None 52 Human Binding pIC50 = 9.1 9.1 -1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL408403 419 None 52 Human Binding pIC50 = 9.1 9.1 -1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
DB11842 419 None 52 Human Binding pIC50 = 9.1 9.1 -1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
15292112 102946 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL306361 102946 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
14956763 163395 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 526 10 1 10 4.2 CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL419483 163395 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 526 10 1 10 4.2 CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
19430458 204072 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 769 16 1 9 8.4 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL70100 204072 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 769 16 1 9 8.4 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 10.1016/S0960-894X(00)80077-3
18950608 15669 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 10.1021/jm00075a033
CHEMBL122224 15669 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 10.1021/jm00075a033
10032361 112724 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 10.1021/jm00043a020
CHEMBL330463 112724 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 10.1021/jm00043a020
9987414 117047 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339113 117047 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44275095 95175 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 536 9 3 7 5.2 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL25585 95175 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 536 9 3 7 5.2 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
18950586 15562 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 10.1021/jm00075a033
CHEMBL122017 15562 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 10.1021/jm00075a033
9986299 158449 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 10.1021/jm00043a020
CHEMBL409058 158449 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 10.1021/jm00043a020
10349392 208048 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 659 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 10.1021/jm00043a020
CHEMBL97557 208048 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 659 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 10.1021/jm00043a020
10372659 118088 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL340632 118088 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
135955119 124489 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 612 9 1 10 4.9 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
CHEMBL3640129 124489 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 612 9 1 10 4.9 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
53321879 57595 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
ChEMBL 470 8 1 5 5.8 CCCCC1=N[C@](C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1667998 57595 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
ChEMBL 470 8 1 5 5.8 CCCCC1=N[C@](C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
44315304 205008 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL76821 205008 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
73349224 92191 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 626 9 1 11 4.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)n2cnnn2)cc1 10.1007/s00044-013-0831-x
CHEMBL2425239 92191 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 626 9 1 11 4.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)n2cnnn2)cc1 10.1007/s00044-013-0831-x
14956757 67591 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 1
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL19018 67591 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 1
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81132-X
14956757 67591 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 1
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00043a020
CHEMBL19018 67591 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 1
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00043a020
14956757 67591 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 1
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00052a006
CHEMBL19018 67591 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 1
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00052a006
44311538 102961 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 699 14 1 10 6.9 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL306435 102961 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 699 14 1 10 6.9 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311183 204698 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74069 204698 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311735 204750 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 753 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74514 204750 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 753 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
15076146 106974 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 423 6 1 6 4.9 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm031100t
CHEMBL315104 106974 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 423 6 1 6 4.9 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm031100t
9914666 116668 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1016/j.bmc.2010.10.043
CHEMBL337086 116668 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1016/j.bmc.2010.10.043
44272246 98787 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 628 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(C)C)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL278305 98787 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 628 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(C)C)cc1 10.1016/S0960-894X(01)81132-X
44272247 98861 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 654 10 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(F)(F)F)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL278977 98861 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 654 10 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(F)(F)F)cc1 10.1016/S0960-894X(01)81132-X
15076146 106974 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 423 6 1 6 4.9 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL315104 106974 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 423 6 1 6 4.9 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
44310586 172645 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneIn vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 524 7 1 6 5.3 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81150-1
CHEMBL449648 172645 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneIn vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 524 7 1 6 5.3 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81150-1
10483888 111453 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1021/jm00043a020
CHEMBL327563 111453 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1021/jm00043a020
10416501 112408 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 9 1 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL329759 112408 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 9 1 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
10483726 207574 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00043a020
CHEMBL94910 207574 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00043a020
183134 204842 None 17 Rabbit Binding pIC50 = 9.1 9.1 - 1
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL7550 204842 None 17 Rabbit Binding pIC50 = 9.1 9.1 - 1
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81145-8
9961192 11364 None 43 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 10.1021/jm00043a020
CHEMBL1179743 11364 None 43 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 10.1021/jm00043a020
CHEMBL97688 11364 None 43 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 10.1021/jm00043a020
10078554 116966 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338687 116966 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10078554 116966 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338687 116966 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10010125 208029 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97464 208029 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 10.1021/jm00043a020
10078554 116966 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338687 116966 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
44275096 94753 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 599 10 1 8 6.4 CCCCc1nc2ccc(N(C)C(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL25315 94753 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 599 10 1 8 6.4 CCCCc1nc2ccc(N(C)C(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
10259265 110041 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 110041 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
10259265 110041 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL323506 110041 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10077497 11367 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 10.1021/jm00043a020
CHEMBL1179757 11367 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 10.1021/jm00043a020
CHEMBL98426 11367 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 10.1021/jm00043a020
11765560 15535 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121872 15535 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44314761 102852 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305647 102852 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
10394712 119375 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 671 12 2 8 6.2 CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL344467 119375 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 671 12 2 8 6.2 CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
14956739 206300 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 1
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL87074 206300 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 1
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
10394712 119375 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 671 12 2 8 6.2 CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344467 119375 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 671 12 2 8 6.2 CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44381528 58991 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 548 10 2 8 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169009 58991 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 548 10 2 8 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10032877 15547 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121907 15547 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44314823 161884 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL415073 161884 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
10484866 31783 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 699 14 2 8 7.0 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-013-0831-x
CHEMBL140619 31783 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 699 14 2 8 7.0 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-013-0831-x
9984181 118446 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 520 12 1 6 5.6 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL341131 118446 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 520 12 1 6 5.6 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
44277573 99539 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL283495 99539 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
44277871 99698 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 599 10 1 9 5.8 CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL28464 99698 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 599 10 1 9 5.8 CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
192626 15657 None 14 Rabbit Binding pIC50 = 9.1 9.1 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 499 11 1 5 6.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 10.1021/jm00075a033
CHEMBL122212 15657 None 14 Rabbit Binding pIC50 = 9.1 9.1 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 499 11 1 5 6.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 10.1021/jm00075a033
1481 2064 None 116 Rat Binding pIC50 = 9.1 9.1 - 3
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/S0960-894X(01)80526-6
3749 2064 None 116 Rat Binding pIC50 = 9.1 9.1 - 3
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/S0960-894X(01)80526-6
589 2064 None 116 Rat Binding pIC50 = 9.1 9.1 - 3
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/S0960-894X(01)80526-6
6908 2064 None 116 Rat Binding pIC50 = 9.1 9.1 - 3
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/S0960-894X(01)80526-6
CHEMBL1513 2064 None 116 Rat Binding pIC50 = 9.1 9.1 - 3
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/S0960-894X(01)80526-6
DB01029 2064 None 116 Rat Binding pIC50 = 9.1 9.1 - 3
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/S0960-894X(01)80526-6
44285267 148446 None 33 Rat Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 414 6 1 5 4.4 CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL39379 148446 None 33 Rat Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 414 6 1 5 4.4 CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
44274731 100065 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 498 8 1 7 4.4 CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL287184 100065 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 498 8 1 7 4.4 CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
70682146 76329 None 0 Human Binding pIC50 = 9.1 9.1 - 1
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058860 76329 None 0 Human Binding pIC50 = 9.1 9.1 - 1
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
10078800 109189 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 109189 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
44311635 102222 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 581 10 2 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(00)80076-1
CHEMBL302959 102222 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 581 10 2 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(00)80076-1
10032988 116915 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 116915 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44385182 61072 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 637 10 3 7 5.7 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL176473 61072 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 637 10 3 7 5.7 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
10484866 31783 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 699 14 2 8 7.0 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL140619 31783 None 0 Rabbit Binding pIC50 = 9.1 9.1 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 699 14 2 8 7.0 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
10372550 164514 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL421478 164514 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10372550 164514 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL421478 164514 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10372550 164514 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL421478 164514 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
145946921 167598 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 592 11 1 7 5.5 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2337687 167598 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 592 11 1 7 5.5 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2337688 167598 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 592 11 1 7 5.5 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL4300967 167598 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 592 11 1 7 5.5 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
44314780 103076 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL307430 103076 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
14956772 105945 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 510 10 1 9 4.6 CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL312913 105945 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 510 10 1 9 4.6 CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
9830839 106929 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 2
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1021/jm00043a020
CHEMBL314812 106929 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 2
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1021/jm00043a020
10078780 116914 None 0 Human Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338433 116914 None 0 Human Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10373120 117599 None 0 Human Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL340078 117599 None 0 Human Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
44381739 58783 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168771 58783 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
44274854 94315 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 537 9 2 8 5.1 CCCCc1nc2ccc(OC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL25056 94315 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 537 9 2 8 5.1 CCCCc1nc2ccc(OC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
44274731 100065 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 498 8 1 7 4.4 CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL287184 100065 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 498 8 1 7 4.4 CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
10055448 30761 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 691 13 2 8 7.3 CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL139582 30761 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 691 13 2 8 7.3 CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
136052335 124485 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 622 8 1 8 5.8 O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4cccc(F)c4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 nan
CHEMBL3640125 124485 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 622 8 1 8 5.8 O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4cccc(F)c4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 nan
136052364 124488 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 608 9 1 10 5.0 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640128 124488 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 608 9 1 10 5.0 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
135876075 124491 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 624 9 1 11 5.6 COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3F)c2=O)cc1 nan
CHEMBL3640131 124491 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 624 9 1 11 5.6 COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3F)c2=O)cc1 nan
11755602 168445 None 0 Rat Binding pIC50 = 9 9.0 - 0
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 497 9 1 9 3.6 CCCCc1nc2ccn(CC(=O)OC)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
CHEMBL43500 168445 None 0 Rat Binding pIC50 = 9 9.0 - 0
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 497 9 1 9 3.6 CCCCc1nc2ccn(CC(=O)OC)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
44311754 102995 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 757 16 1 9 9.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL306761 102995 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 757 16 1 9 9.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311071 103413 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 707 18 1 9 8.0 CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL308482 103413 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 707 18 1 9 8.0 CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 10.1016/S0960-894X(00)80077-3
3036053 101331 None 13 Rat Binding pIC50 = 9 9.0 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 409 6 1 6 4.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm031100t
CHEMBL296725 101331 None 13 Rat Binding pIC50 = 9 9.0 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 409 6 1 6 4.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm031100t
10322211 169470 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
ChEMBL 464 6 1 7 4.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 10.1016/j.bmc.2010.10.043
CHEMBL442963 169470 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
ChEMBL 464 6 1 7 4.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 10.1016/j.bmc.2010.10.043
15818748 99911 None 0 Rat Binding pIC50 = 9 9.0 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 543 9 1 5 5.7 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL286134 99911 None 0 Rat Binding pIC50 = 9 9.0 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 543 9 1 5 5.7 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
9850811 154738 None 0 Rat Binding pIC50 = 9 9.0 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 561 8 1 6 5.3 CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL39996 154738 None 0 Rat Binding pIC50 = 9 9.0 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 561 8 1 6 5.3 CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
2583 3774 None 118 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2013.08.014
592 3774 None 118 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2013.08.014
65999 3774 None 118 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2013.08.014
CHEMBL1017 3774 None 118 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2013.08.014
DB00966 3774 None 118 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2013.08.014
2583 3774 None 118 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
592 3774 None 118 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
65999 3774 None 118 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
CHEMBL1017 3774 None 118 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
DB00966 3774 None 118 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
2583 3774 None 118 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmc.2012.05.056
592 3774 None 118 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmc.2012.05.056
65999 3774 None 118 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmc.2012.05.056
CHEMBL1017 3774 None 118 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmc.2012.05.056
DB00966 3774 None 118 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmc.2012.05.056
19939454 207555 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 761 15 2 8 8.2 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
CHEMBL94793 207555 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 761 15 2 8 8.2 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
3036053 101331 None 13 Rabbit Binding pIC50 = 9 9.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 409 6 1 6 4.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL296725 101331 None 13 Rabbit Binding pIC50 = 9 9.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 409 6 1 6 4.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
9851889 102072 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81115-X
CHEMBL302102 102072 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81115-X
3036053 101331 None 13 Rabbit Binding pIC50 = 9 9.0 - 0
In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.
ChEMBL 409 6 1 6 4.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80044-X
CHEMBL296725 101331 None 13 Rabbit Binding pIC50 = 9 9.0 - 0
In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.
ChEMBL 409 6 1 6 4.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80044-X
44289008 164862 None 0 Rat Binding pIC50 = 9 9.0 - 0
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 442 7 1 5 5.2 CCCCC1=NC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81139-2
CHEMBL42200 164862 None 0 Rat Binding pIC50 = 9 9.0 - 0
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 442 7 1 5 5.2 CCCCC1=NC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81139-2
10417031 107384 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 669 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 10.1021/jm00043a020
CHEMBL317864 107384 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 669 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 10.1021/jm00043a020
10439253 112319 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 10.1021/jm00043a020
CHEMBL329255 112319 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 10.1021/jm00043a020
10439837 16351 None 0 Human Binding pIC50 = 9 9.0 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122917 16351 None 0 Human Binding pIC50 = 9 9.0 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
44348523 113177 None 0 Human Binding pIC50 = 9 9.0 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL331450 113177 None 0 Human Binding pIC50 = 9 9.0 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
10462683 113280 None 0 Human Binding pIC50 = 9 9.0 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331507 113280 None 0 Human Binding pIC50 = 9 9.0 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9851082 101018 None 0 Human Binding pIC50 = 9 9.0 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
CHEMBL294512 101018 None 0 Human Binding pIC50 = 9 9.0 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
44381739 58783 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL168771 58783 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL938 215905 None 28 Human Binding pIC50 = 9 9.0 1 2
Inhibition of human AT1 receptorInhibition of human AT1 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm701575k
10055448 30761 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 691 13 2 8 7.3 CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139582 30761 None 0 Rabbit Binding pIC50 = 9 9.0 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 691 13 2 8 7.3 CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
1037 1576 None 69 Rat Binding pIC50 = 9 9.0 - 1
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
3940 1576 None 69 Rat Binding pIC50 = 9 9.0 - 1
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
5281037 1576 None 69 Rat Binding pIC50 = 9 9.0 - 1
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
588 1576 None 69 Rat Binding pIC50 = 9 9.0 - 1
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
CHEMBL813 1576 None 69 Rat Binding pIC50 = 9 9.0 - 1
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
DB00876 1576 None 69 Rat Binding pIC50 = 9 9.0 - 1
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
14952924 197928 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 458 10 2 5 5.4 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1 10.1016/S0960-894X(01)81116-1
CHEMBL57309 197928 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 458 10 2 5 5.4 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1 10.1016/S0960-894X(01)81116-1
136052282 124486 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 594 8 1 9 5.2 O=C(Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(F)cc1 nan
CHEMBL3640126 124486 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 594 8 1 9 5.2 O=C(Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(F)cc1 nan
136052259 124492 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 606 9 1 11 5.5 COc1cccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2=O)c1 nan
CHEMBL3640132 124492 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 606 9 1 11 5.5 COc1cccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2=O)c1 nan
44277676 99317 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 613 11 0 9 6.1 CCCCCN(C(=O)c1ccccc1OC)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL282167 99317 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 613 11 0 9 6.1 CCCCCN(C(=O)c1ccccc1OC)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
10028209 101415 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 482 9 2 8 2.9 CCCCc1nc2ccn(CC(N)=O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
CHEMBL297358 101415 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 482 9 2 8 2.9 CCCCc1nc2ccn(CC(N)=O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
3936 2208 None 35 Human Binding pIC50 = 9.0 9.0 1 4
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT1R (unknown origin) by radioligand binding assayDisplacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT1R (unknown origin) by radioligand binding assay
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116804
6603900 2208 None 35 Human Binding pIC50 = 9.0 9.0 1 4
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT1R (unknown origin) by radioligand binding assayDisplacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT1R (unknown origin) by radioligand binding assay
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116804
CHEMBL288174 2208 None 35 Human Binding pIC50 = 9.0 9.0 1 4
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT1R (unknown origin) by radioligand binding assayDisplacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT1R (unknown origin) by radioligand binding assay
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116804
44274692 96444 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 541 10 2 7 6.2 CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL26217 96444 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 541 10 2 7 6.2 CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
9955424 165122 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 450 7 1 6 4.9 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL422756 165122 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 450 7 1 6 4.9 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
127034873 136447 None 0 Human Binding pIC50 = 9.0 9.0 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735744 136447 None 0 Human Binding pIC50 = 9.0 9.0 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
44379183 120813 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 571 10 1 6 6.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL355708 120813 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 571 10 1 6 6.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1016/S0960-894X(01)81125-2
10461785 11921 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 639 10 1 9 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 10.1021/jm00043a020
CHEMBL1182712 11921 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 639 10 1 9 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 10.1021/jm00043a020
CHEMBL262296 11921 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 639 10 1 9 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 10.1021/jm00043a020
10348847 112587 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 615 10 2 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1021/jm00043a020
CHEMBL330170 112587 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 615 10 2 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1021/jm00043a020
10484119 168106 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL432822 168106 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 10.1021/jm00043a020
10054188 207519 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 592 9 1 7 5.1 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL94582 207519 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 592 9 1 7 5.1 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
10462933 16880 None 0 Human Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL125008 16880 None 0 Human Binding pIC50 = 9.0 9.0 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
3936 2208 None 35 Human Binding pIC50 = 9.0 9.0 1 4
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm9504722
6603900 2208 None 35 Human Binding pIC50 = 9.0 9.0 1 4
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm9504722
CHEMBL288174 2208 None 35 Human Binding pIC50 = 9.0 9.0 1 4
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm9504722
44381670 120482 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 657 11 3 9 6.0 CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL354298 120482 None 0 Rabbit Binding pIC50 = 9.0 9.0 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 657 11 3 9 6.0 CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 10.1016/S0960-894X(01)81126-4
10392378 16516 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 535 12 1 7 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL123671 16516 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 535 12 1 7 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
10325267 16861 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 550 12 1 9 4.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL124913 16861 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 550 12 1 9 4.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
14956757 67591 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 1
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL19018 67591 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 1
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
136052261 124484 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 618 8 1 8 5.9 Cc1ccc(CCn2c(=O)c3cc(CC(F)(F)F)sc3n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2=O)cc1 nan
CHEMBL3640124 124484 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 618 8 1 8 5.9 Cc1ccc(CCn2c(=O)c3cc(CC(F)(F)F)sc3n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2=O)cc1 nan
136052281 124490 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 606 9 1 11 5.5 COc1ccccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3noc(O)n3)cc2)c1=O nan
CHEMBL3640130 124490 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 606 9 1 11 5.5 COc1ccccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3noc(O)n3)cc2)c1=O nan
136052251 124501 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 544 7 1 9 4.5 CCc1cc2c(=O)n(CC(=O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640140 124501 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 544 7 1 9 4.5 CCc1cc2c(=O)n(CC(=O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
136052396 124519 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 610 6 1 9 5.7 CCc1cc2c(=O)n(-c3ccc4c(c3)CC(C)(C)O4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
CHEMBL3640158 124519 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 610 6 1 9 5.7 CCc1cc2c(=O)n(-c3ccc4c(c3)CC(C)(C)O4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
136052283 124520 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 556 7 1 9 4.8 CC(C)(C)C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O nan
CHEMBL3640159 124520 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 556 7 1 9 4.8 CC(C)(C)C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O nan
44277677 99318 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 585 9 1 9 5.5 CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL282168 99318 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 585 9 1 9 5.5 CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
18950598 15540 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C 10.1021/jm00075a033
CHEMBL121891 15540 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C 10.1021/jm00075a033
73355475 92623 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 9 2 4 6.9 CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435827 92623 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 9 2 4 6.9 CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
14956757 67591 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 1
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin AT1 receptor in rabbit aortic membranesDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin AT1 receptor in rabbit aortic membranes
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL19018 67591 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 1
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin AT1 receptor in rabbit aortic membranesDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin AT1 receptor in rabbit aortic membranes
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
14956779 68661 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin AT1 receptor in rabbit aortic membranesDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin AT1 receptor in rabbit aortic membranes
ChEMBL 445 8 1 7 4.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL19202 68661 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin AT1 receptor in rabbit aortic membranesDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin AT1 receptor in rabbit aortic membranes
ChEMBL 445 8 1 7 4.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
10078048 106878 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 12 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1021/jm00043a020
CHEMBL314514 106878 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 12 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1021/jm00043a020
9986951 207765 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 10.1021/jm00043a020
CHEMBL95955 207765 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 10.1021/jm00043a020
44314822 102947 None 0 Human Binding pIC50 = 8.9 8.9 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 102947 None 0 Human Binding pIC50 = 8.9 8.9 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
44315058 70451 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL194608 70451 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
9869504 208045 None 4 Human Binding pIC50 = 8.9 8.9 - 0
Tested for Angiotensin II receptor, type 1 affinity in the absence of BSATested for Angiotensin II receptor, type 1 affinity in the absence of BSA
ChEMBL 474 10 2 5 5.9 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 10.1016/S0960-894X(01)81116-1
CHEMBL97533 208045 None 4 Human Binding pIC50 = 8.9 8.9 - 0
Tested for Angiotensin II receptor, type 1 affinity in the absence of BSATested for Angiotensin II receptor, type 1 affinity in the absence of BSA
ChEMBL 474 10 2 5 5.9 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 10.1016/S0960-894X(01)81116-1
44274673 93738 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 451 7 2 7 4.2 CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL24724 93738 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 451 7 2 7 4.2 CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
10254585 112902 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 480 13 1 5 5.2 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL331042 112902 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 480 13 1 5 5.2 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
136052277 124514 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 656 10 1 11 5.3 CCc1cc2c(=O)n(CC(OC(C)=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
CHEMBL3640153 124514 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 656 10 1 11 5.3 CCc1cc2c(=O)n(CC(OC(C)=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
137662335 160833 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 593 9 1 10 4.9 CCc1cc2c(=O)n(C/C(=N\OC)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL4114708 160833 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 593 9 1 10 4.9 CCc1cc2c(=O)n(C/C(=N\OC)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
44277902 99792 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 627 11 0 10 5.3 CC(=O)OCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL28532 99792 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 627 11 0 10 5.3 CC(=O)OCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
44274673 93738 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 451 7 2 7 4.2 CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL24724 93738 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 451 7 2 7 4.2 CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
1481 2064 None 116 Rat Binding pIC50 = 8.9 8.9 -1 3
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm00074a018
3749 2064 None 116 Rat Binding pIC50 = 8.9 8.9 -1 3
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm00074a018
589 2064 None 116 Rat Binding pIC50 = 8.9 8.9 -1 3
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm00074a018
6908 2064 None 116 Rat Binding pIC50 = 8.9 8.9 -1 3
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm00074a018
CHEMBL1513 2064 None 116 Rat Binding pIC50 = 8.9 8.9 -1 3
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm00074a018
DB01029 2064 None 116 Rat Binding pIC50 = 8.9 8.9 -1 3
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm00074a018
22574723 15936 None 0 Human Binding pIC50 = 8.9 8.9 - 1
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 549 11 2 7 5.2 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 10.1039/C4MD00499J
CHEMBL12233 15936 None 0 Human Binding pIC50 = 8.9 8.9 - 1
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 549 11 2 7 5.2 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 10.1039/C4MD00499J
57380647 70352 None 0 Human Binding pIC50 = 8.9 8.9 - 1
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945010 70352 None 0 Human Binding pIC50 = 8.9 8.9 - 1
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
70686410 76328 None 0 Human Binding pIC50 = 8.9 8.9 - 1
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 555 10 2 6 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058859 76328 None 0 Human Binding pIC50 = 8.9 8.9 - 1
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 555 10 2 6 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
19939409 107158 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 710 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL316299 107158 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 710 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
1481 2064 None 116 Rat Binding pIC50 = 8.9 8.9 -1 3
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/S0960-894X(01)81139-2
3749 2064 None 116 Rat Binding pIC50 = 8.9 8.9 -1 3
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/S0960-894X(01)81139-2
589 2064 None 116 Rat Binding pIC50 = 8.9 8.9 -1 3
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/S0960-894X(01)81139-2
6908 2064 None 116 Rat Binding pIC50 = 8.9 8.9 -1 3
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/S0960-894X(01)81139-2
CHEMBL1513 2064 None 116 Rat Binding pIC50 = 8.9 8.9 -1 3
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/S0960-894X(01)81139-2
DB01029 2064 None 116 Rat Binding pIC50 = 8.9 8.9 -1 3
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/S0960-894X(01)81139-2
10372341 168196 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 10.1021/jm00043a020
CHEMBL433375 168196 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 10.1021/jm00043a020
10077929 207343 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 643 14 2 8 5.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1021/jm00043a020
CHEMBL93606 207343 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 643 14 2 8 5.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1021/jm00043a020
10326460 208105 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 614 9 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL97897 208105 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 614 9 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 10.1021/jm00043a020
10009735 158203 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 676 3 1 7 6.9 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 10.1016/0960-894X(96)00116-3
CHEMBL408798 158203 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 676 3 1 7 6.9 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 10.1016/0960-894X(96)00116-3
76311803 84968 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 592 12 3 11 4.6 CCCCc1nnc(SCc2ccccc2-c2nnn[nH]2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237602 84968 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 592 12 3 11 4.6 CCCCc1nnc(SCc2ccccc2-c2nnn[nH]2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
9987311 116755 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 706 12 1 9 6.7 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL337588 116755 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 706 12 1 9 6.7 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10414470 17127 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 524 11 2 7 4.8 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9205-9
CHEMBL125542 17127 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 524 11 2 7 4.8 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9205-9
44320012 167921 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 1
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 493 9 1 7 5.4 CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL431411 167921 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 1
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 493 9 1 7 5.4 CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
136052301 124493 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 594 9 1 11 5.2 CCc1cc2c(=O)n(CC(=O)c3ccccc3OC)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2s1 nan
CHEMBL3640133 124493 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 594 9 1 11 5.2 CCc1cc2c(=O)n(CC(=O)c3ccccc3OC)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2s1 nan
136052255 124497 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 684 9 1 10 5.6 COc1ccccc1C(=O)Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2c(F)cc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O nan
CHEMBL3640137 124497 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 684 9 1 10 5.6 COc1ccccc1C(=O)Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2c(F)cc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O nan
136052247 124507 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 558 7 2 9 4.6 CC(C)(C)C(O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O nan
CHEMBL3640146 124507 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 558 7 2 9 4.6 CC(C)(C)C(O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O nan
136052300 124516 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 630 9 1 10 5.0 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)c(F)c3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3F)c2s1 nan
CHEMBL3640155 124516 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 630 9 1 10 5.0 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)c(F)c3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3F)c2s1 nan
136052332 124524 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 630 9 1 10 5.0 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
CHEMBL3640162 124524 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 630 9 1 10 5.0 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
136052372 124528 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 564 8 1 9 4.7 CCc1cc2c(=O)n(CC(=O)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640166 124528 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 564 8 1 9 4.7 CCc1cc2c(=O)n(CC(=O)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
136052324 124530 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 570 8 1 10 4.8 CCc1cc2c(=O)n(CC(=O)c3cccs3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640171 124530 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 570 8 1 10 4.8 CCc1cc2c(=O)n(CC(=O)c3cccs3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
10481968 50692 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 525 11 2 8 5.5 CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL157577 50692 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 525 11 2 8 5.5 CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
15236320 172604 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1
ChEMBL 548 10 1 7 6.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL449095 172604 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1
ChEMBL 548 10 1 7 6.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
10054324 98351 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 600 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL275160 98351 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 600 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
10099040 120239 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 549 11 2 10 5.0 CCCCc1nnc(SCc2ccccc2-c2nn[nH]n2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL352236 120239 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 549 11 2 10 5.0 CCCCc1nnc(SCc2ccccc2-c2nn[nH]n2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
9852384 100414 None 5 Rat Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]Ang II from AT1 receptor in rat liver membranesDisplacement of [125I]Ang II from AT1 receptor in rat liver membranes
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.9b01780
CHEMBL290214 100414 None 5 Rat Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]Ang II from AT1 receptor in rat liver membranesDisplacement of [125I]Ang II from AT1 receptor in rat liver membranes
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.9b01780
127035265 136534 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 601 11 2 7 7.3 CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3736514 136534 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 601 11 2 7 7.3 CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
10417195 109077 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321313 109077 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
10054324 98351 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL275160 98351 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10101690 116859 None 0 Human Binding pIC50 = 8.9 8.9 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338137 116859 None 0 Human Binding pIC50 = 8.9 8.9 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9852384 100414 None 5 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
CHEMBL290214 100414 None 5 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
44305410 162357 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 556 10 3 8 3.5 CCCc1cc(=O)n(CCNC(=O)NC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL416507 162357 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 556 10 3 8 3.5 CCCc1cc(=O)n(CCNC(=O)NC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
9987311 116755 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 706 12 1 9 6.7 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL337588 116755 None 0 Rabbit Binding pIC50 = 8.9 8.9 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 706 12 1 9 6.7 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10321941 138145 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 458 10 2 5 5.4 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl 10.1016/S0960-894X(01)81116-1
CHEMBL37679 138145 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 458 10 2 5 5.4 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl 10.1016/S0960-894X(01)81116-1
19010048 84966 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 568 12 3 9 5.1 CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237600 84966 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 568 12 3 9 5.1 CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
10327728 98120 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL273542 98120 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10369867 16375 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 534 12 1 6 5.9 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)cs2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL122966 16375 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 534 12 1 6 5.9 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)cs2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
135876074 124487 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 612 9 1 10 4.9 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3F)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640127 124487 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 612 9 1 10 4.9 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3F)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
136052291 124503 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 642 9 1 10 5.3 COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2=O)cc1 nan
CHEMBL3640142 124503 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 642 9 1 10 5.3 COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2=O)cc1 nan
136052286 124504 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 624 8 1 9 5.5 O=C(Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)C1CCCCC1 nan
CHEMBL3640143 124504 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 624 8 1 9 5.5 O=C(Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)C1CCCCC1 nan
136052352 124506 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 573 8 1 10 4.9 CCc1cc2c(=O)n(C/C(=N/OC)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640145 124506 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 573 8 1 10 4.9 CCc1cc2c(=O)n(C/C(=N/OC)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
136052270 124510 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 602 10 1 11 4.0 CCc1cc2c(=O)n(CC(=O)C(C)(C)COC(C)=O)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640149 124510 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 602 10 1 11 4.0 CCc1cc2c(=O)n(CC(=O)C(C)(C)COC(C)=O)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
136052397 124512 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 604 8 1 10 5.4 CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)s3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640151 124512 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 604 8 1 10 5.4 CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)s3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
136052320 124513 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 614 9 2 10 4.7 CCc1cc2c(=O)n(CC(O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
CHEMBL3640152 124513 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 614 9 2 10 4.7 CCc1cc2c(=O)n(CC(O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
136052319 124525 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 612 9 1 10 4.9 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccc(F)cc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640163 124525 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 612 9 1 10 4.9 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccc(F)cc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
136052299 124527 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 570 8 1 9 5.0 CCc1cc2c(=O)n(CC(=O)C3CCCCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640165 124527 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 570 8 1 9 5.0 CCc1cc2c(=O)n(CC(=O)C3CCCCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
1610 2345 None 95 Rat Binding pIC50 = 8.8 8.8 -1 4
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00037a014
3941 2345 None 95 Rat Binding pIC50 = 8.8 8.8 -1 4
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00037a014
3961 2345 None 95 Rat Binding pIC50 = 8.8 8.8 -1 4
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00037a014
590 2345 None 95 Rat Binding pIC50 = 8.8 8.8 -1 4
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00037a014
CHEMBL191 2345 None 95 Rat Binding pIC50 = 8.8 8.8 -1 4
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00037a014
DB00678 2345 None 95 Rat Binding pIC50 = 8.8 8.8 -1 4
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00037a014
10481968 50692 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 525 11 2 8 5.5 CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL157577 50692 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 525 11 2 8 5.5 CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
9850834 154660 None 17 Human Binding pIC50 = 8.8 8.8 - 1
Displacement of [125I]-[Sar1,Leu8]angiotensin II from human AT1 receptor expressed in african green monkey COS7 cellsDisplacement of [125I]-[Sar1,Leu8]angiotensin II from human AT1 receptor expressed in african green monkey COS7 cells
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
CHEMBL39959 154660 None 17 Human Binding pIC50 = 8.8 8.8 - 1
Displacement of [125I]-[Sar1,Leu8]angiotensin II from human AT1 receptor expressed in african green monkey COS7 cellsDisplacement of [125I]-[Sar1,Leu8]angiotensin II from human AT1 receptor expressed in african green monkey COS7 cells
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
44379292 120332 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 613 12 1 6 7.4 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL352934 120332 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 613 12 1 6 7.4 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81125-2
10327728 98120 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL273542 98120 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10438523 208142 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 10 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
CHEMBL98126 208142 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 10 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
11765454 118066 None 0 Human Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL340473 118066 None 0 Human Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315144 96590 None 0 Human Binding pIC50 = 8.8 8.8 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL263191 96590 None 0 Human Binding pIC50 = 8.8 8.8 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
9851889 102072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL302102 102072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44300838 198668 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 530 7 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL57976 198668 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 530 7 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
9850834 154660 None 17 Human Binding pIC50 = 8.8 8.8 - 1
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
CHEMBL39959 154660 None 17 Human Binding pIC50 = 8.8 8.8 - 1
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
9851889 102072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
CHEMBL302102 102072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
44211672 158204 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 706 4 1 8 7.4 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
CHEMBL408799 158204 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 706 4 1 8 7.4 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
10327728 98120 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL273542 98120 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10484986 118695 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 713 11 1 9 6.8 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL341715 118695 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 713 11 1 9 6.8 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
136052375 124483 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 638 8 1 8 6.3 O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4ccc(Cl)cc4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 nan
CHEMBL3640123 124483 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 638 8 1 8 6.3 O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4ccc(Cl)cc4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 nan
136052302 124498 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 642 9 1 10 5.3 COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O nan
CHEMBL3640138 124498 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 642 9 1 10 5.3 COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O nan
136052246 124499 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 624 9 1 10 5.2 COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O nan
CHEMBL3640139 124499 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 624 9 1 10 5.2 COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O nan
136052258 124518 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 598 8 1 9 5.8 CCc1cc2c(=O)n(-c3ccc(OC(C)C)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
CHEMBL3640157 124518 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 598 8 1 9 5.8 CCc1cc2c(=O)n(-c3ccc(OC(C)C)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
136052298 124529 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 637 11 1 11 5.3 CCO/N=C(/Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 nan
CHEMBL3640167 124529 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 637 11 1 11 5.3 CCO/N=C(/Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 nan
136052297 124532 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 578 8 1 8 5.8 CCc1cc2c(=O)n(CC(C)(C)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2s1 nan
CHEMBL3640173 124532 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 578 8 1 8 5.8 CCc1cc2c(=O)n(CC(C)(C)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2s1 nan
44277903 99116 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 585 10 0 9 5.0 CCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL280908 99116 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 585 10 0 9 5.0 CCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
11764826 98282 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 648 11 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL274710 98282 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 648 11 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
15231091 93986 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL24861 93986 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
44274823 99073 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 551 10 2 8 5.8 CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL280526 99073 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 551 10 2 8 5.8 CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
45102750 63776 None 4 Human Binding pIC50 = 8.8 8.8 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 477 6 1 6 5.9 CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL1801740 63776 None 4 Human Binding pIC50 = 8.8 8.8 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 477 6 1 6 5.9 CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
45102750 63776 None 4 Human Binding pIC50 = 8.8 8.8 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 477 6 1 6 5.9 CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
CHEMBL1801740 63776 None 4 Human Binding pIC50 = 8.8 8.8 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 477 6 1 6 5.9 CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
19754050 203878 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 603 15 2 7 6.6 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68786 203878 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 603 15 2 7 6.6 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 10.1016/S0960-894X(01)81115-X
11764826 98282 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 11 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 10.1021/jm00043a020
CHEMBL274710 98282 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 11 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 10.1021/jm00043a020
10233056 107157 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 637 10 1 8 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 10.1021/jm00043a020
CHEMBL316297 107157 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 637 10 1 8 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 10.1021/jm00043a020
10259525 15617 None 0 Human Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122158 15617 None 0 Human Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259841 16156 None 0 Human Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122401 16156 None 0 Human Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
44315351 104883 None 0 Human Binding pIC50 = 8.8 8.8 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL311160 104883 None 0 Human Binding pIC50 = 8.8 8.8 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
10484986 118695 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 713 11 1 9 6.8 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341715 118695 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 713 11 1 9 6.8 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10030086 16975 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 535 12 1 7 5.3 CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL125383 16975 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 535 12 1 7 5.3 CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
136052394 124496 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 598 8 1 9 5.4 CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640136 124496 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 598 8 1 9 5.4 CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
136052399 124502 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 622 8 1 9 5.6 CCc1cc2c(=O)n(CC(=O)C34CC5CC(CC(C5)C3)C4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640141 124502 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 622 8 1 9 5.6 CCc1cc2c(=O)n(CC(=O)C34CC5CC(CC(C5)C3)C4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
136052347 124505 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 618 8 1 11 4.6 CCc1cc2c(=O)n(CC(=O)c3nc4ccccc4n3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640144 124505 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 618 8 1 11 4.6 CCc1cc2c(=O)n(CC(=O)c3nc4ccccc4n3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
136052345 124508 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 530 7 1 9 3.9 CCc1cc2c(=O)n(CC3(C)COC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640147 124508 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 530 7 1 9 3.9 CCc1cc2c(=O)n(CC3(C)COC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
136052268 124509 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 560 7 2 10 3.4 CCc1cc2c(=O)n(CC3(O)CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640148 124509 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 560 7 2 10 3.4 CCc1cc2c(=O)n(CC3(O)CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
136052310 124517 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 626 10 1 10 5.3 CCCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
CHEMBL3640156 124517 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 626 10 1 10 5.3 CCCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
136052379 124523 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 672 9 1 11 5.9 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3Br)c2s1 nan
CHEMBL3640161 124523 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 672 9 1 11 5.9 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3Br)c2s1 nan
9851889 102072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
CHEMBL302102 102072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
44277573 99539 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL283495 99539 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
44277442 100295 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 583 10 0 8 6.1 CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL28917 100295 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 583 10 0 8 6.1 CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
44277451 100904 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 601 10 0 8 6.3 CCCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL29386 100904 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 601 10 0 8 6.3 CCCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
44283174 100072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 617 9 1 7 7.2 CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL287250 100072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 617 9 1 7 7.2 CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
9851889 102072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)80595-3
CHEMBL302102 102072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)80595-3
44310589 168096 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneIn vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 488 6 1 5 5.4 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 10.1016/S0960-894X(01)81150-1
CHEMBL432734 168096 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneIn vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 488 6 1 5 5.4 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 10.1016/S0960-894X(01)81150-1
9851889 102072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00019a004
CHEMBL302102 102072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00019a004
44377199 57417 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 531 10 2 6 4.9 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL165349 57417 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 531 10 2 6 4.9 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
9851889 102072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm9504722
CHEMBL302102 102072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm9504722
9801006 119727 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 1
Inhibitory activity was evaluated against angiotensin II type 1 rabbit aortaInhibitory activity was evaluated against angiotensin II type 1 rabbit aorta
ChEMBL 398 6 1 7 3.6 CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 10.1021/jm9504722
CHEMBL347610 119727 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 1
Inhibitory activity was evaluated against angiotensin II type 1 rabbit aortaInhibitory activity was evaluated against angiotensin II type 1 rabbit aorta
ChEMBL 398 6 1 7 3.6 CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 10.1021/jm9504722
9851889 102072 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm058225d
CHEMBL302102 102072 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm058225d
9851889 102072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00052a006
CHEMBL302102 102072 None 0 Rabbit Binding pIC50 = 8.8 8.8 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00052a006
10258916 29709 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 668 11 1 10 6.1 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-013-0831-x
CHEMBL138654 29709 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 668 11 1 10 6.1 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1007/s00044-013-0831-x
10010164 117395 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL339806 117395 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
9845644 206431 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 431 9 1 7 4.3 CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL87964 206431 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 431 9 1 7 4.3 CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
136052351 124494 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 608 9 1 11 5.5 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3C)c2s1 nan
CHEMBL3640134 124494 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 608 9 1 11 5.5 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3C)c2s1 nan
136052241 124495 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 577 8 1 10 3.3 CCc1cc2c(=O)n(CCN3CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
CHEMBL3640135 124495 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 577 8 1 10 3.3 CCc1cc2c(=O)n(CCN3CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 nan
136052269 124511 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 546 7 2 9 4.3 CCc1cc2c(=O)n(CC(O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640150 124511 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 546 7 2 9 4.3 CCc1cc2c(=O)n(CC(O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
136052400 124526 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 612 9 1 10 4.9 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4cc(F)ccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640164 124526 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 612 9 1 10 4.9 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4cc(F)ccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
136401533 160839 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 649 12 1 11 5.5 C=CCO/N=C(\Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 nan
CHEMBL4114807 160839 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 649 12 1 11 5.5 C=CCO/N=C(\Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 nan
108185 1612 None 78 Rat Binding pIC50 = 8.7 8.7 - 1
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00037a014
586 1612 None 78 Rat Binding pIC50 = 8.7 8.7 - 1
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00037a014
CHEMBL907 1612 None 78 Rat Binding pIC50 = 8.7 8.7 - 1
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00037a014
10010164 117395 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339806 117395 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10100074 112558 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 9 1 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL330007 112558 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 9 1 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 10.1021/jm00043a020
9810305 98570 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL276674 98570 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
10258916 29709 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 668 11 1 10 6.1 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL138654 29709 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 668 11 1 10 6.1 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
10010164 117395 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL339806 117395 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10394859 17427 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL125760 17427 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
9960721 16309 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 549 12 0 8 5.4 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL122638 16309 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 549 12 0 8 5.4 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
59351471 124515 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 417 5 1 6 3.9 CCc1cc2c(=O)[nH]c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3OC)c2s1 nan
CHEMBL3640154 124515 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 417 5 1 6 3.9 CCc1cc2c(=O)[nH]c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3OC)c2s1 nan
136052367 124531 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 648 8 1 10 5.6 CCc1cc2c(=O)n(CC(=O)c3sccc3Br)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL3640172 124531 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 648 8 1 10 5.6 CCc1cc2c(=O)n(CC(=O)c3sccc3Br)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
44277652 99822 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 573 8 0 8 5.5 CCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL28555 99822 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 573 8 0 8 5.5 CCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
2806 3967 None 110 Rat Binding pIC50 = 8.7 8.7 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm031100t
3937 3967 None 110 Rat Binding pIC50 = 8.7 8.7 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm031100t
593 3967 None 110 Rat Binding pIC50 = 8.7 8.7 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm031100t
60846 3967 None 110 Rat Binding pIC50 = 8.7 8.7 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm031100t
CHEMBL1069 3967 None 110 Rat Binding pIC50 = 8.7 8.7 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm031100t
DB00177 3967 None 110 Rat Binding pIC50 = 8.7 8.7 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm031100t
10394859 17427 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL125760 17427 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44376746 119857 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 568 16 2 7 5.9 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL348758 119857 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 568 16 2 7 5.9 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
10033136 16071 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122380 16071 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
44315078 204754 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74556 204754 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44303230 200645 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL59957 200645 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
10394859 17427 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL125760 17427 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
76308179 84973 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 584 12 3 9 4.1 CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237607 84973 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 584 12 3 9 4.1 CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
10222835 206143 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 403 8 1 7 3.3 CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL86084 206143 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 403 8 1 7 3.3 CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44459556 98729 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 436 6 1 6 4.6 CCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL277902 98729 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 436 6 1 6 4.6 CCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
19087866 98934 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 436 7 1 6 4.6 CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL279515 98934 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 436 7 1 6 4.6 CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
44459544 99367 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 454 7 1 6 4.8 CCCCc1nc2cccc(F)c2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL282526 99367 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 454 7 1 6 4.8 CCCCc1nc2cccc(F)c2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
44311428 102967 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 647 17 1 8 7.1 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306473 102967 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 647 17 1 8 7.1 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311543 104139 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 643 14 1 8 6.3 CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL309455 104139 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 643 14 1 8 6.3 CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10069786 169099 None 0 Rat Binding pIC50 = 8 8.0 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 404 7 1 3 5.3 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL439968 169099 None 0 Rat Binding pIC50 = 8 8.0 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 404 7 1 3 5.3 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
19008869 206412 None 0 Rat Binding pIC50 = 8 8.0 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 385 5 1 4 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm031100t
CHEMBL87842 206412 None 0 Rat Binding pIC50 = 8 8.0 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 385 5 1 4 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm031100t
10325037 119785 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 541 11 2 8 4.5 CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL348143 119785 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 541 11 2 8 4.5 CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
73353933 92617 None 0 Human Binding pIC50 = 8 8.0 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 554 11 2 6 5.2 CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435821 92617 None 0 Human Binding pIC50 = 8 8.0 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 554 11 2 6 5.2 CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
70696780 76218 None 0 Bovine Binding pIC50 = 8 8.0 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 592 9 1 6 7.3 CCCCc1nc2ccc(Br)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058374 76218 None 0 Bovine Binding pIC50 = 8 8.0 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 592 9 1 6 7.3 CCCCc1nc2ccc(Br)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
19102815 207876 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL96554 207876 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
44311342 102179 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 611 12 3 7 5.9 CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL302760 102179 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 611 12 3 7 5.9 CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311450 104099 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 652 12 2 8 6.4 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309365 104099 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 652 12 2 8 6.4 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311688 104194 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 554 10 2 8 3.5 CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309820 104194 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 554 10 2 8 3.5 CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222101 158560 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 642 12 2 9 4.2 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL409170 158560 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 642 12 2 9 4.2 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(00)80076-1
44311664 204161 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 680 12 2 8 5.9 CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70638 204161 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 680 12 2 8 5.9 CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311449 204478 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 549 10 2 9 3.9 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL72409 204478 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 549 10 2 9 3.9 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15292111 204743 None 0 Human Binding pIC50 = 8 8.0 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74442 204743 None 0 Human Binding pIC50 = 8 8.0 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10100413 198588 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 620 9 1 7 7.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL57853 198588 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 620 9 1 7 7.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
44300798 198953 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 558 8 1 7 6.1 CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
CHEMBL58499 198953 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 558 8 1 7 6.1 CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
9845644 206431 None 0 Rat Binding pIC50 = 8 8.0 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 431 9 1 7 4.3 CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL87964 206431 None 0 Rat Binding pIC50 = 8 8.0 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 431 9 1 7 4.3 CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
9985329 22134 None 0 Rat Binding pIC50 = 8 8.0 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 562 9 2 6 6.8 CCCCc1nc2ccc(N(C)C(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
CHEMBL132226 22134 None 0 Rat Binding pIC50 = 8 8.0 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 562 9 2 6 6.8 CCCCc1nc2ccc(N(C)C(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
15287894 54945 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(95)00185-V
CHEMBL16148 54945 None 0 Rabbit Binding pIC50 = 8 8.0 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(95)00185-V
10324361 16924 None 0 Human Binding pIC50 = 8 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 519 12 0 8 4.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccno2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL125273 16924 None 0 Human Binding pIC50 = 8 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 519 12 0 8 4.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccno2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
16133225 419 None 52 Human Binding pIC50 = 8.0 8.0 -1 4
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
172198 419 None 52 Human Binding pIC50 = 8.0 8.0 -1 4
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
2504 419 None 52 Human Binding pIC50 = 8.0 8.0 -1 4
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
45266664 419 None 52 Human Binding pIC50 = 8.0 8.0 -1 4
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
5272 419 None 52 Human Binding pIC50 = 8.0 8.0 -1 4
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
CHEMBL408403 419 None 52 Human Binding pIC50 = 8.0 8.0 -1 4
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
DB11842 419 None 52 Human Binding pIC50 = 8.0 8.0 -1 4
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
53309130 63770 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 449 4 1 6 5.6 Cc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 10.1021/jm200409s
CHEMBL1801734 63770 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 449 4 1 6 5.6 Cc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 10.1021/jm200409s
70690542 76219 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 532 9 1 6 6.6 CCCCc1nc2ccc(F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058375 76219 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 532 9 1 6 6.6 CCCCc1nc2ccc(F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
53309128 63780 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 453 6 1 4 6.4 CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3C(=O)O)ccc21 10.1021/jm200409s
CHEMBL1801744 63780 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 453 6 1 4 6.4 CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3C(=O)O)ccc21 10.1021/jm200409s
44277549 99126 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 594 8 0 10 5.1 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL280988 99126 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 594 8 0 10 5.1 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
2541 785 None 120 Human Binding pIC50 = 8.0 8.0 -1 6
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
587 785 None 120 Human Binding pIC50 = 8.0 8.0 -1 6
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
6907 785 None 120 Human Binding pIC50 = 8.0 8.0 -1 6
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL1016 785 None 120 Human Binding pIC50 = 8.0 8.0 -1 6
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
DB00796 785 None 120 Human Binding pIC50 = 8.0 8.0 -1 6
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
DB13919 785 None 120 Human Binding pIC50 = 8.0 8.0 -1 6
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
76315368 84953 None 0 Rabbit Binding pIC50 = 7 7.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 510 10 2 8 5.3 CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237587 84953 None 0 Rabbit Binding pIC50 = 7 7.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 510 10 2 8 5.3 CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
14956760 165498 None 0 Rabbit Binding pIC50 = 7 7.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 466 8 2 8 3.9 CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL424053 165498 None 0 Rabbit Binding pIC50 = 7 7.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 466 8 2 8 3.9 CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44348352 16526 None 0 Bovine Binding pIC50 = 7 7.0 - 1
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 459 8 1 6 4.5 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC 10.1016/S0960-894X(01)80914-8
CHEMBL123713 16526 None 0 Bovine Binding pIC50 = 7 7.0 - 1
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 459 8 1 6 4.5 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC 10.1016/S0960-894X(01)80914-8
44285157 154703 None 0 Rat Binding pIC50 = 7 7.0 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 484 6 1 5 5.2 CC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL39978 154703 None 0 Rat Binding pIC50 = 7 7.0 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 484 6 1 5 5.2 CC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
10412300 48146 None 0 Rabbit Binding pIC50 = 7 7.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 467 9 1 7 5.7 CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL155154 48146 None 0 Rabbit Binding pIC50 = 7 7.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 467 9 1 7 5.7 CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
44311472 103790 None 0 Human Binding pIC50 = 7 7.0 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 669 14 3 8 5.7 CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL308943 103790 None 0 Human Binding pIC50 = 7 7.0 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 669 14 3 8 5.7 CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
10500716 10226 None 0 Bovine Binding pIC50 = 7 7.0 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 392 8 2 4 4.5 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL116054 10226 None 0 Bovine Binding pIC50 = 7 7.0 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 392 8 2 4 4.5 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
9867446 169315 None 0 Bovine Binding pIC50 = 7 7.0 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 432 8 3 7 3.1 CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
CHEMBL441649 169315 None 0 Bovine Binding pIC50 = 7 7.0 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 432 8 3 7 3.1 CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
44305424 102491 None 0 Bovine Binding pIC50 = 7 7.0 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 388 6 2 6 2.4 CCCc1cc(=O)[nH]c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL304032 102491 None 0 Bovine Binding pIC50 = 7 7.0 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 388 6 2 6 2.4 CCCc1cc(=O)[nH]c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
10434949 119640 None 0 Rabbit Binding pIC50 = 6 6.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 472 9 2 6 5.0 CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL346745 119640 None 0 Rabbit Binding pIC50 = 6 6.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 472 9 2 6 5.0 CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
10456123 165315 None 0 Rabbit Binding pIC50 = 6 6.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 444 9 2 6 4.9 CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL423418 165315 None 0 Rabbit Binding pIC50 = 6 6.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 444 9 2 6 4.9 CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
76310609 105246 None 0 Human Binding pIC50 = 6 6.0 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 531 10 2 4 7.3 CCCn1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmcl.2014.01.004
CHEMBL3115244 105246 None 0 Human Binding pIC50 = 6 6.0 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 531 10 2 4 7.3 CCCn1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmcl.2014.01.004
44298831 194981 None 0 Bovine Binding pIC50 = 6 6.0 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 496 8 2 8 4.2 CC(C)COc1nc2ccc(C(C)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
CHEMBL54699 194981 None 0 Bovine Binding pIC50 = 6 6.0 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 496 8 2 8 4.2 CC(C)COc1nc2ccc(C(C)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
10434949 119640 None 0 Rabbit Binding pIC50 = 6 6.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 472 9 2 6 5.0 CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL346745 119640 None 0 Rabbit Binding pIC50 = 6 6.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 472 9 2 6 5.0 CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
10456123 165315 None 0 Rabbit Binding pIC50 = 6 6.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 444 9 2 6 4.9 CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL423418 165315 None 0 Rabbit Binding pIC50 = 6 6.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 444 9 2 6 4.9 CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
15654731 102191 None 0 Bovine Binding pIC50 = 6 6.0 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 482 9 1 8 4.9 CCCOc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL302815 102191 None 0 Bovine Binding pIC50 = 6 6.0 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 482 9 1 8 4.9 CCCOc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
44305441 100943 None 0 Bovine Binding pIC50 = 6 6.0 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 388 5 1 7 2.0 CCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL294075 100943 None 0 Bovine Binding pIC50 = 6 6.0 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 388 5 1 7 2.0 CCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
44341795 9942 None 0 Rat Binding pIC50 = 5 5.0 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 516 6 1 3 5.9 O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2C(F)(F)C(F)(F)C(F)(F)F)cc1 10.1021/jm00074a018
CHEMBL114625 9942 None 0 Rat Binding pIC50 = 5 5.0 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 516 6 1 3 5.9 O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2C(F)(F)C(F)(F)C(F)(F)F)cc1 10.1021/jm00074a018
15144937 18830 None 0 Rat Binding pIC50 = 5 5.0 - 0
Compound was evaluated for the inhibition of [125I]AII specific binding to rat mesenteric arteriesCompound was evaluated for the inhibition of [125I]AII specific binding to rat mesenteric arteries
ChEMBL 500 11 1 4 7.4 CCCCc1ncc(/C=C(\Cc2cccc(Oc3ccccc3)c2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
CHEMBL128032 18830 None 0 Rat Binding pIC50 = 5 5.0 - 0
Compound was evaluated for the inhibition of [125I]AII specific binding to rat mesenteric arteriesCompound was evaluated for the inhibition of [125I]AII specific binding to rat mesenteric arteries
ChEMBL 500 11 1 4 7.4 CCCCc1ncc(/C=C(\Cc2cccc(Oc3ccccc3)c2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
44303886 100878 None 0 Rabbit Binding pIC50 = 5 5.0 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 522 11 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL293660 100878 None 0 Rabbit Binding pIC50 = 5 5.0 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 522 11 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44303852 102347 None 0 Rabbit Binding pIC50 = 5 5.0 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 524 11 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL303755 102347 None 0 Rabbit Binding pIC50 = 5 5.0 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 524 11 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
73346387 92628 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 497 7 1 5 5.2 CCCc1nc2c(C)cc(C(=O)N3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435832 92628 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 497 7 1 5 5.2 CCCc1nc2c(C)cc(C(=O)N3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
9866104 203893 None 0 Rat Binding pIC50 = 7 7.0 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 407 10 1 5 4.6 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00067a015
CHEMBL68919 203893 None 0 Rat Binding pIC50 = 7 7.0 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 407 10 1 5 4.6 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00067a015
9850385 101690 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 544 8 1 8 5.2 CCCCc1nc2ccc(C3=NN4CCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL299391 101690 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 544 8 1 8 5.2 CCCCc1nc2ccc(C3=NN4CCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
11757908 117332 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 578 12 0 6 6.8 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc3ccccc3c2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL339709 117332 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 578 12 0 6 6.8 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc3ccccc3c2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
127034874 136403 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 547 10 3 5 6.2 CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735333 136403 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 547 10 3 5 6.2 CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
44212049 101462 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 560 8 1 7 6.7 CCCCc1nc2ccc(C3CCC4CCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL297714 101462 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 560 8 1 7 6.7 CCCCc1nc2ccc(C3CCC4CCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
44297113 101573 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 637 9 1 9 6.8 CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccc(C)cc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL298560 101573 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 637 9 1 9 6.8 CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccc(C)cc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
11388072 205830 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 634 9 1 9 6.3 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)NS(=O)(=O)c3ccc([N+](=O)[O-])cc3)cnc3ccccc23)cc1 10.1021/jm031100t
CHEMBL83414 205830 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 634 9 1 9 6.3 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)NS(=O)(=O)c3ccc([N+](=O)[O-])cc3)cnc3ccccc23)cc1 10.1021/jm031100t
57380648 70372 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 549 10 2 4 6.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945148 70372 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 549 10 2 4 6.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
127034876 136424 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 571 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735487 136424 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 571 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
10453551 19096 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 399 7 2 4 5.4 CCCCc1nc2cccc(N)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL128913 19096 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 399 7 2 4 5.4 CCCCc1nc2cccc(N)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
24827768 159092 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 411 6 1 7 3.5 CCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL409744 159092 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 411 6 1 7 3.5 CCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
15356438 186858 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 425 9 2 5 4.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(=O)c2ccccc2)cc1 10.1021/jm00064a007
CHEMBL48955 186858 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 425 9 2 5 4.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(=O)c2ccccc2)cc1 10.1021/jm00064a007
10483230 46828 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 574 11 2 8 5.1 CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-011-9756-4
CHEMBL154027 46828 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 574 11 2 8 5.1 CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-011-9756-4
19939367 105948 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL312921 105948 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
14956792 106764 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL314447 106764 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
14956754 157383 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 541 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL407827 157383 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 541 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44277440 98960 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4cccnc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL279756 98960 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4cccnc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
44307171 100920 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 481 5 2 5 4.7 CCCc1nc2c(C)cc(C(=O)O)nc2n1Cc1cc(Br)c(O)c(Br)c1 10.1016/S0960-894X(01)81148-3
CHEMBL293926 100920 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 481 5 2 5 4.7 CCCc1nc2c(C)cc(C(=O)O)nc2n1Cc1cc(Br)c(O)c(Br)c1 10.1016/S0960-894X(01)81148-3
11374350 206402 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 450 6 1 5 6.0 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 10.1021/jm031100t
CHEMBL87779 206402 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 450 6 1 5 6.0 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 10.1021/jm031100t
44373246 168265 None 0 Bovine Binding pIC50 = 8.0 8.0 - 1
Binding affinity to angiotensin AT1 receptor in bovine adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in bovine adrenal cortex membranes
ChEMBL 435 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 10.1016/j.bmc.2010.10.043
CHEMBL433895 168265 None 0 Bovine Binding pIC50 = 8.0 8.0 - 1
Binding affinity to angiotensin AT1 receptor in bovine adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in bovine adrenal cortex membranes
ChEMBL 435 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 10.1016/j.bmc.2010.10.043
9824568 204411 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
ChEMBL 441 5 2 7 2.8 Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm0204237
CHEMBL72053 204411 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
ChEMBL 441 5 2 7 2.8 Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm0204237
108185 1612 None 78 Rat Binding pIC50 = 8.0 8.0 - 1
Concentration required to inhibit binding of radioligand [125I]AII to Angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to Angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00092a017
586 1612 None 78 Rat Binding pIC50 = 8.0 8.0 - 1
Concentration required to inhibit binding of radioligand [125I]AII to Angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to Angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00092a017
CHEMBL907 1612 None 78 Rat Binding pIC50 = 8.0 8.0 - 1
Concentration required to inhibit binding of radioligand [125I]AII to Angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to Angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00092a017
10052777 48516 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 531 10 1 7 5.5 CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL155638 48516 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 531 10 1 7 5.5 CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
73355474 92615 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 540 10 2 6 4.8 CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435819 92615 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 540 10 2 6 4.8 CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
70696781 76220 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 582 9 1 6 7.5 CCCCc1nc2ccc(C(F)(F)F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058376 76220 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 582 9 1 6 7.5 CCCCc1nc2ccc(C(F)(F)F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
15236329 169332 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 598 6 1 7 6.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3Br)[S+]([O-])N2)cc1 10.1016/S0960-894X(01)81119-7
CHEMBL441837 169332 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 598 6 1 7 6.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3Br)[S+]([O-])N2)cc1 10.1016/S0960-894X(01)81119-7
10501285 163433 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 402 7 2 6 3.7 CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
CHEMBL419762 163433 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 402 7 2 6 3.7 CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
44320817 106990 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Inhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranesInhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranes
ChEMBL 529 7 1 7 5.3 CCCCc1nc(Cl)c2n1[C@H](c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC[C@@H]2N1C(=O)CCC1=O 10.1016/S0960-894X(01)80290-0
CHEMBL315219 106990 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Inhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranesInhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranes
ChEMBL 529 7 1 7 5.3 CCCCc1nc(Cl)c2n1[C@H](c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC[C@@H]2N1C(=O)CCC1=O 10.1016/S0960-894X(01)80290-0
44384871 129318 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 726 14 1 7 8.0 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
CHEMBL367095 129318 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 726 14 1 7 8.0 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
11754522 22199 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 471 7 1 6 5.9 CCCc1nc2ccc(-c3ccccn3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
CHEMBL132282 22199 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 471 7 1 6 5.9 CCCc1nc2ccc(-c3ccccn3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
10095637 49965 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 457 9 1 5 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15689 49965 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 457 9 1 5 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
19385665 51059 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 471 9 1 5 6.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C 10.1016/0960-894X(95)00185-V
CHEMBL15788 51059 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 471 9 1 5 6.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C 10.1016/0960-894X(95)00185-V
10053367 117244 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 553 12 0 7 5.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C#N)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL339480 117244 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 553 12 0 7 5.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C#N)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
10029695 158522 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 521 10 0 8 4.7 CCCCc1ncc(/C=C2/C(=O)N(CC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL409136 158522 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 521 10 0 8 4.7 CCCCc1ncc(/C=C2/C(=O)N(CC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
9983135 168603 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 492 11 0 6 5.4 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2C=C(C)C)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL435994 168603 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 492 11 0 6 5.4 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2C=C(C)C)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL5271484 193684 None 0 Human Binding pIC50 = 8.0 8.0 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 315 3 1 4 2.8 CS(=O)(=O)n1c(-c2ccccc2)c(C(=O)O)c2ccccc21 10.1016/j.bmcl.2023.129349
44309702 203738 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 591 13 2 8 6.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL67805 203738 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 591 13 2 8 6.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
9869504 208045 None 4 Rat Binding pIC50 = 7.9 7.9 - 0
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 474 10 2 5 5.9 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 10.1016/S0960-894X(01)81116-1
CHEMBL97533 208045 None 4 Rat Binding pIC50 = 7.9 7.9 - 0
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 474 10 2 5 5.9 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 10.1016/S0960-894X(01)81116-1
76322689 84957 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 558 11 2 8 6.0 CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237591 84957 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 558 11 2 8 6.0 CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
14956796 205797 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL83182 205797 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44342013 9553 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 509 9 1 4 6.0 CCCCC1=NC2(CCN(Cc3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL112343 9553 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 509 9 1 4 6.0 CCCCC1=NC2(CCN(Cc3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
19976676 206448 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 416 10 1 7 4.3 CCCCc1nc(CCCC)n(Cc2ccc(-c3cccnc3-c3nn[nH]n3)cc2)n1 10.1021/jm031100t
CHEMBL88067 206448 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 416 10 1 7 4.3 CCCCc1nc(CCCC)n(Cc2ccc(-c3cccnc3-c3nn[nH]n3)cc2)n1 10.1021/jm031100t
2541 785 None 120 Human Binding pIC50 = 7.0 7.0 -1 6
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2010.10.043
587 785 None 120 Human Binding pIC50 = 7.0 7.0 -1 6
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2010.10.043
6907 785 None 120 Human Binding pIC50 = 7.0 7.0 -1 6
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2010.10.043
CHEMBL1016 785 None 120 Human Binding pIC50 = 7.0 7.0 -1 6
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2010.10.043
DB00796 785 None 120 Human Binding pIC50 = 7.0 7.0 -1 6
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2010.10.043
DB13919 785 None 120 Human Binding pIC50 = 7.0 7.0 -1 6
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2010.10.043
2541 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/S0960-894X(01)81118-5
587 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/S0960-894X(01)81118-5
6907 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/S0960-894X(01)81118-5
CHEMBL1016 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/S0960-894X(01)81118-5
DB00796 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/S0960-894X(01)81118-5
DB13919 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/S0960-894X(01)81118-5
2541 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/0960-894X(95)00319-O
587 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/0960-894X(95)00319-O
6907 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/0960-894X(95)00319-O
CHEMBL1016 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/0960-894X(95)00319-O
DB00796 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/0960-894X(95)00319-O
DB13919 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/0960-894X(95)00319-O
10006742 47920 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 515 10 1 7 6.5 CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL154949 47920 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 515 10 1 7 6.5 CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
9847539 182037 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 470 8 1 5 5.8 CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL47810 182037 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 470 8 1 5 5.8 CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81140-9
44297172 162216 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 587 8 2 10 2.9 CCCCc1nc2ccc(C3=NN[C@H]4C(=O)N(C)C(=O)[C@@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL416296 162216 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 587 8 2 10 2.9 CCCCc1nc2ccc(C3=NN[C@H]4C(=O)N(C)C(=O)[C@@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
10671263 9974 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 450 10 3 5 5.0 CCCc1nc(C(O)(CC)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL114788 9974 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 450 10 3 5 5.0 CCCc1nc(C(O)(CC)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
10571686 10079 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 378 7 2 4 4.3 CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL115392 10079 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 378 7 2 4 4.3 CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
19939495 207823 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL96314 207823 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
2541 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm00067a016
587 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm00067a016
6907 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm00067a016
CHEMBL1016 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm00067a016
DB00796 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm00067a016
DB13919 785 None 120 Bovine Binding pIC50 = 7.0 7.0 - 6
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm00067a016
4110026 204933 None 1 Bovine Binding pIC50 = 7.0 7.0 - 1
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 384 7 1 3 5.8 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1007/s00044-009-9182-z
CHEMBL7632 204933 None 1 Bovine Binding pIC50 = 7.0 7.0 - 1
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 384 7 1 3 5.8 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1007/s00044-009-9182-z
9886554 97104 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 387 8 2 5 3.9 CCCCc1nc(CO)c(Cl)n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1021/jm00053a013
CHEMBL267547 97104 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 387 8 2 5 3.9 CCCCc1nc(CO)c(Cl)n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1021/jm00053a013
15699062 4925 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 376 7 2 4 3.6 CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(C(=O)O)C2 10.1021/jm00114a021
CHEMBL104684 4925 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 376 7 2 4 3.6 CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(C(=O)O)C2 10.1021/jm00114a021
15699051 5771 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 396 7 2 6 3.8 CCCCc1nc(Cl)c(CO)n1Cc1cccc2c(-c3nn[nH]n3)cccc12 10.1021/jm00114a021
CHEMBL107862 5771 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 396 7 2 6 3.8 CCCCc1nc(Cl)c(CO)n1Cc1cccc2c(-c3nn[nH]n3)cccc12 10.1021/jm00114a021
44293476 101959 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 500 12 3 6 4.7 CCCCc1ncc(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
CHEMBL301328 101959 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 500 12 3 6 4.7 CCCCc1ncc(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
44307088 102201 None 0 Rabbit Binding pIC50 = 6.0 6.0 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 465 4 1 6 3.8 CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(C(=O)OC)c1 10.1016/S0960-894X(01)81148-3
CHEMBL302869 102201 None 0 Rabbit Binding pIC50 = 6.0 6.0 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 465 4 1 6 3.8 CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(C(=O)OC)c1 10.1016/S0960-894X(01)81148-3
44295557 101774 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 1 6 5.3 CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL299980 101774 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 1 6 5.3 CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
19792135 189501 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 424 7 2 6 5.0 CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL51399 189501 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 424 7 2 6 5.0 CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
15355267 193202 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 486 8 2 6 5.6 CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL52343 193202 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 486 8 2 6 5.6 CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
4110026 204933 None 1 Bovine Binding pIC50 = 6.0 6.0 - 1
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 384 7 1 3 5.8 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1007/s00044-009-9182-z
CHEMBL7632 204933 None 1 Bovine Binding pIC50 = 6.0 6.0 - 1
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 384 7 1 3 5.8 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1007/s00044-009-9182-z
53837978 170447 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of human AT1 receptorInhibition of human AT1 receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/acs.jmedchem.9b01780
CHEMBL4448705 170447 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of human AT1 receptorInhibition of human AT1 receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/acs.jmedchem.9b01780
44306628 203476 None 0 Rabbit Binding pIC50 = 5.0 5.0 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 421 3 0 3 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)cc(Br)c1 10.1016/S0960-894X(01)81148-3
CHEMBL66056 203476 None 0 Rabbit Binding pIC50 = 5.0 5.0 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 421 3 0 3 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)cc(Br)c1 10.1016/S0960-894X(01)81148-3
44295557 101774 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 1 6 5.3 CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL299980 101774 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 1 6 5.3 CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
19792135 189501 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 424 7 2 6 5.0 CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL51399 189501 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 424 7 2 6 5.0 CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
15355267 193202 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 486 8 2 6 5.6 CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL52343 193202 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 486 8 2 6 5.6 CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
127034905 136357 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 561 10 2 4 7.8 CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3734859 136357 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 561 10 2 4 7.8 CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
44293652 101426 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 534 11 2 7 5.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](c2ccccc2)n2cccc2C(=O)OC)cc1 10.1021/jm00064a007
CHEMBL297465 101426 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 534 11 2 7 5.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](c2ccccc2)n2cccc2C(=O)OC)cc1 10.1021/jm00064a007
24828714 96161 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 453 8 1 8 4.0 CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc2c1=O 10.1021/jm7011563
CHEMBL260578 96161 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 453 8 1 8 4.0 CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc2c1=O 10.1021/jm7011563
14956759 206100 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 495 9 2 8 4.0 CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL85704 206100 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 495 9 2 8 4.0 CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
73350990 92616 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 545 11 2 4 7.1 CCCc1nc2c(C)cc(C(=O)NCCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435820 92616 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 545 11 2 4 7.1 CCCc1nc2c(C)cc(C(=O)NCCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
19889359 160185 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 410 6 1 7 4.0 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 10.1021/jm031100t
CHEMBL410939 160185 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 410 6 1 7 4.0 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 10.1021/jm031100t
19889359 160185 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.
ChEMBL 410 6 1 7 4.0 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80044-X
CHEMBL410939 160185 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.
ChEMBL 410 6 1 7 4.0 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80044-X
10257293 16917 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 562 12 0 6 6.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(Cl)c2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL125233 16917 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 562 12 0 6 6.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(Cl)c2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
70690743 76633 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 466 8 2 6 4.4 CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
CHEMBL2063981 76633 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 466 8 2 6 4.4 CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
70690743 76633 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 466 8 2 6 4.4 CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
CHEMBL2063981 76633 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 466 8 2 6 4.4 CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
14950487 94604 None 0 Guinea pig Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 401 6 2 6 3.8 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)O)c(C)n1 10.1021/jm00061a016
CHEMBL25220 94604 None 0 Guinea pig Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 401 6 2 6 3.8 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)O)c(C)n1 10.1021/jm00061a016
70688502 76326 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 571 10 2 7 6.1 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058857 76326 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 571 10 2 7 6.1 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
44459867 93883 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Ability to displace [125I]Sar1-Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 504 7 1 6 5.7 CCCCc1nc2ccc(C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL24802 93883 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Ability to displace [125I]Sar1-Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 504 7 1 6 5.7 CCCCc1nc2ccc(C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
44274710 99934 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Ability to displace [125I]Sar1-Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 562 7 1 6 5.2 CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL286260 99934 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Ability to displace [125I]Sar1-Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 562 7 1 6 5.2 CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
14956793 206306 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL87129 206306 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
14956798 206407 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 523 10 1 9 4.0 CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL87798 206407 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 523 10 1 9 4.0 CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
11397357 107012 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 474 6 1 7 5.4 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 10.1021/jm031100t
CHEMBL315387 107012 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 474 6 1 7 5.4 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 10.1021/jm031100t
9954408 207965 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 430 10 1 6 4.7 CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL9714 207965 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 430 10 1 6 4.7 CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
70684240 76221 None 0 Bovine Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 559 10 1 8 6.4 CCCCc1nc2ccc([N+](=O)[O-])cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058377 76221 None 0 Bovine Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 559 10 1 8 6.4 CCCCc1nc2ccc([N+](=O)[O-])cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
44274710 99934 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 562 7 1 6 5.2 CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL286260 99934 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 562 7 1 6 5.2 CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
19422649 101294 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 446 8 1 3 6.3 CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL296492 101294 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 446 8 1 3 6.3 CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
44379347 120485 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 544 9 1 7 4.3 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL354338 120485 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 544 9 1 7 4.3 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
44379291 120514 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 702 15 2 8 7.5 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL354535 120514 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 702 15 2 8 7.5 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)81125-2
3081289 10022 None 11 Bovine Binding pIC50 = 7.9 7.9 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 416 8 2 6 4.0 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
CHEMBL115021 10022 None 11 Bovine Binding pIC50 = 7.9 7.9 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 416 8 2 6 4.0 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
44377075 119975 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 479 10 1 6 4.1 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349869 119975 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 479 10 1 6 4.1 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
44315180 102894 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305956 102894 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
15292112 102946 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL306361 102946 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
14951068 102103 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 475 12 2 8 3.5 CCCCc1nn(CCCCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL302261 102103 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 475 12 2 8 3.5 CCCCc1nn(CCCCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
14951083 102604 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 509 11 1 8 4.7 CCCCc1nn(CC(OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL304134 102604 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 509 11 1 8 4.7 CCCCc1nn(CC(OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
44270330 51744 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 471 10 1 5 6.2 CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15847 51744 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 471 10 1 5 6.2 CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
44270278 98862 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 443 8 1 5 5.4 CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL278983 98862 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 443 8 1 5 5.4 CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL5272962 193739 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 341 3 1 3 4.7 O=C(O)c1c(-c2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 10.1016/j.bmcl.2023.129349
10324657 113715 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 528 12 0 6 5.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL332323 113715 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 528 12 0 6 5.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
46184983 86818 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 513 6 1 7 5.2 CCc1nc2ccn(Cc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322437 86818 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 513 6 1 7 5.2 CCc1nc2ccn(Cc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
44295057 101332 None 0 Bovine Binding pIC50 = 6.9 6.9 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 473 7 1 6 4.8 CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80474-6
CHEMBL296731 101332 None 0 Bovine Binding pIC50 = 6.9 6.9 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 473 7 1 6 4.8 CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80474-6
44295068 189018 None 0 Bovine Binding pIC50 = 6.9 6.9 - 0
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 473 8 1 6 4.9 CCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(00)80474-6
CHEMBL50906 189018 None 0 Bovine Binding pIC50 = 6.9 6.9 - 0
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 473 8 1 6 4.9 CCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(00)80474-6
44274691 95565 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 583 9 2 8 4.9 CCCCc1nc2ccc(NS(=O)(=O)C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL25767 95565 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 583 9 2 8 4.9 CCCCc1nc2ccc(NS(=O)(=O)C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
19010044 84963 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 582 12 2 10 5.2 CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237597 84963 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 582 12 2 10 5.2 CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
14956742 206326 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL87275 206326 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
9984755 47950 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 539 11 1 9 5.6 CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL154975 47950 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 539 11 1 9 5.6 CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
10074143 48995 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 486 10 2 6 5.5 CCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL156070 48995 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 486 10 2 6 5.5 CCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
1610 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
3941 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
3961 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
590 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
CHEMBL191 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
DB00678 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
44358304 116789 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 521 5 1 6 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3ccccc3N2)cc1 10.1016/S0960-894X(01)81119-7
CHEMBL337787 116789 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 521 5 1 6 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3ccccc3N2)cc1 10.1016/S0960-894X(01)81119-7
1610 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm950450f
3941 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm950450f
3961 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm950450f
590 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm950450f
CHEMBL191 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm950450f
DB00678 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm950450f
11754802 116517 None 0 Guinea pig Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 441 6 1 5 5.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(Cl)cccc2n1 10.1021/jm00100a007
CHEMBL336167 116517 None 0 Guinea pig Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 441 6 1 5 5.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(Cl)cccc2n1 10.1021/jm00100a007
15231808 105999 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranesInhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranes
ChEMBL 396 6 1 5 5.1 CCCCc1ncc2n1C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC=C2 10.1016/S0960-894X(01)80290-0
CHEMBL313239 105999 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranesInhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranes
ChEMBL 396 6 1 5 5.1 CCCCc1ncc2n1C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC=C2 10.1016/S0960-894X(01)80290-0
14950499 99516 None 0 Guinea pig Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 387 6 2 6 3.6 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c(C)n1 10.1021/jm00061a016
CHEMBL283372 99516 None 0 Guinea pig Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 387 6 2 6 3.6 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c(C)n1 10.1021/jm00061a016
1610 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81143-4
3941 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81143-4
3961 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81143-4
590 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81143-4
CHEMBL191 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81143-4
DB00678 2345 None 95 Bovine Binding pIC50 = 6.9 6.9 - 4
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81143-4
15654764 102703 None 0 Bovine Binding pIC50 = 6.9 6.9 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 470 8 2 7 5.1 CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL304772 102703 None 0 Bovine Binding pIC50 = 6.9 6.9 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 470 8 2 7 5.1 CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
10181864 204296 None 0 Bovine Binding pIC50 = 6.9 6.9 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 442 6 2 7 4.4 CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL71384 204296 None 0 Bovine Binding pIC50 = 6.9 6.9 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 442 6 2 7 4.4 CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
19385644 98749 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 519 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 10.1016/0960-894X(95)00185-V
CHEMBL278061 98749 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 519 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 10.1016/0960-894X(95)00185-V
10481742 120074 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 518 11 2 7 6.1 CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL350697 120074 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 518 11 2 7 6.1 CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44352156 168629 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 432 6 1 7 5.4 CCSc1nc2c(C)scc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81118-5
CHEMBL436192 168629 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 432 6 1 7 5.4 CCSc1nc2c(C)scc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81118-5
15780090 100453 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 631 9 1 7 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL290669 100453 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 631 9 1 7 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10481742 120074 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 518 11 2 7 6.1 CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL350697 120074 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 518 11 2 7 6.1 CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
19792113 188218 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 508 11 1 7 6.2 CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 10.1007/s00044-009-9182-z
CHEMBL49930 188218 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 508 11 1 7 6.2 CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 10.1007/s00044-009-9182-z
10322185 19934 None 0 Guinea pig Binding pIC50 = 5.9 5.9 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 427 5 1 5 5.6 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(Cl)ccc2n1 10.1021/jm00100a007
CHEMBL130275 19934 None 0 Guinea pig Binding pIC50 = 5.9 5.9 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 427 5 1 5 5.6 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(Cl)ccc2n1 10.1021/jm00100a007
10000936 20248 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 398 7 1 3 6.1 CCCCc1nc2c(C)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL130539 20248 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 398 7 1 3 6.1 CCCCc1nc2c(C)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
10250277 21591 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 398 7 1 3 6.1 CCCCc1nc2cc(C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL131722 21591 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 398 7 1 3 6.1 CCCCc1nc2cc(C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
15696755 148021 None 1 Rat Binding pIC50 = 4.9 4.9 - 0
Compound was evaluated for the inhibition of Angiotensin II receptor induced vasoconstriction of the rabbit aortaCompound was evaluated for the inhibition of Angiotensin II receptor induced vasoconstriction of the rabbit aorta
ChEMBL 306 7 1 3 3.6 CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
CHEMBL39345 148021 None 1 Rat Binding pIC50 = 4.9 4.9 - 0
Compound was evaluated for the inhibition of Angiotensin II receptor induced vasoconstriction of the rabbit aortaCompound was evaluated for the inhibition of Angiotensin II receptor induced vasoconstriction of the rabbit aorta
ChEMBL 306 7 1 3 3.6 CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
24827771 96381 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 439 7 1 7 4.1 CC(C)CCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL261765 96381 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 439 7 1 7 4.1 CC(C)CCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
24828035 96919 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 454 8 2 8 3.9 CCCCn1c(=O)c2ccc(NC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL265958 96919 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 454 8 2 8 3.9 CCCCn1c(=O)c2ccc(NC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
689043 36794 None 115 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassayDisplacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassay
ChEMBL 180 2 3 3 1.2 O=C(O)/C=C/c1ccc(O)c(O)c1 10.1021/acs.jmedchem.1c00123
CHEMBL145 36794 None 115 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassayDisplacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassay
ChEMBL 180 2 3 3 1.2 O=C(O)/C=C/c1ccc(O)c(O)c1 10.1021/acs.jmedchem.1c00123
18655106 200467 None 0 Rabbit Binding pIC50 = 4.9 4.9 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)81007-6
CHEMBL59854 200467 None 0 Rabbit Binding pIC50 = 4.9 4.9 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)81007-6
76310606 105242 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 531 10 2 4 7.3 CCCc1nc2cc(C(=O)NC(CC)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmcl.2014.01.004
CHEMBL3115236 105242 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 531 10 2 4 7.3 CCCc1nc2cc(C(=O)NC(CC)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmcl.2014.01.004
127036106 136366 None 0 Human Binding pIC50 = 6.9 6.9 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 571 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3734949 136366 None 0 Human Binding pIC50 = 6.9 6.9 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 571 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
44294022 186623 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 543 12 2 6 5.7 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C#N)c2)cc1 10.1021/jm00064a007
CHEMBL48798 186623 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 543 12 2 6 5.7 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C#N)c2)cc1 10.1021/jm00064a007
44275144 93660 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 496 9 1 8 4.7 CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL24688 93660 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 496 9 1 8 4.7 CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
44275144 93660 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 496 9 1 8 4.7 CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL24688 93660 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 496 9 1 8 4.7 CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
11340575 106981 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 479 7 2 6 5.9 CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 10.1021/jm031100t
CHEMBL315165 106981 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 479 7 2 6 5.9 CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 10.1021/jm031100t
11476484 206060 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 451 5 2 6 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 10.1021/jm031100t
CHEMBL85405 206060 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 451 5 2 6 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 10.1021/jm031100t
11351776 206208 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 465 6 2 6 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(NC)nc3ccccc23)cc1 10.1021/jm031100t
CHEMBL86562 206208 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 465 6 2 6 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(NC)nc3ccccc23)cc1 10.1021/jm031100t
9896251 98771 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Compound was evaluated for inhibitory activity against human Angiotensin II receptor, type 1Compound was evaluated for inhibitory activity against human Angiotensin II receptor, type 1
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm020138n
CHEMBL278176 98771 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Compound was evaluated for inhibitory activity against human Angiotensin II receptor, type 1Compound was evaluated for inhibitory activity against human Angiotensin II receptor, type 1
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm020138n
127034758 136368 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 681 12 1 8 7.7 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)cc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1039/C4MD00499J
CHEMBL3734968 136368 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 681 12 1 8 7.7 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)cc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1039/C4MD00499J
9913391 51160 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 488 8 1 7 5.7 CCCCc1nn2c(C)c(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL157980 51160 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 488 8 1 7 5.7 CCCCc1nn2c(C)c(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
73357017 92627 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 483 10 2 4 6.2 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
CHEMBL2435831 92627 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 483 10 2 4 6.2 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
10027148 116651 None 0 Guinea pig Binding pIC50 = 7.9 7.9 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 421 6 1 5 5.5 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C)cccc2n1 10.1021/jm00100a007
CHEMBL337017 116651 None 0 Guinea pig Binding pIC50 = 7.9 7.9 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 421 6 1 5 5.5 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C)cccc2n1 10.1021/jm00100a007
44377262 57147 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 450 8 0 8 4.4 CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL164617 57147 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 450 8 0 8 4.4 CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 10.1016/S0960-894X(01)81124-0
10437270 107411 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 538 9 1 7 4.6 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1021/jm00043a020
CHEMBL318042 107411 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 538 9 1 7 4.6 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1021/jm00043a020
10416422 207997 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 620 9 1 7 5.8 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97295 207997 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 620 9 1 7 5.8 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10437261 117020 None 1 Rat Binding pIC50 = 7.9 7.9 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 538 7 1 7 6.7 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
CHEMBL338954 117020 None 1 Rat Binding pIC50 = 7.9 7.9 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 538 7 1 7 6.7 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
44404967 135416 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 680 12 1 8 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 10.1021/jm058225d
CHEMBL372814 135416 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 680 12 1 8 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 10.1021/jm058225d
53309129 63769 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 449 5 1 6 5.4 CCCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
CHEMBL1801714 63769 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 449 5 1 6 5.4 CCCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
71521416 86826 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 538 6 1 8 5.1 CCc1nc2ccn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322445 86826 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 538 6 1 8 5.1 CCc1nc2ccn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
76322690 84960 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 569 12 2 10 5.3 CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237594 84960 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 569 12 2 10 5.3 CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
10055421 51406 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 526 11 1 9 5.7 CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL158188 51406 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 526 11 1 9 5.7 CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
15698058 187121 None 0 Bovine Binding pIC50 = 6.9 6.9 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 412 8 2 4 5.0 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL49170 187121 None 0 Bovine Binding pIC50 = 6.9 6.9 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 412 8 2 4 5.0 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
14950501 85007 None 0 Guinea pig Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 371 5 1 5 4.4 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C)c(C)n1 10.1021/jm00061a016
CHEMBL22387 85007 None 0 Guinea pig Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 371 5 1 5 4.4 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C)c(C)n1 10.1021/jm00061a016
15698058 187121 None 0 Bovine Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 412 8 2 4 5.0 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
CHEMBL49170 187121 None 0 Bovine Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 412 8 2 4 5.0 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
15355266 194584 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 2 6 5.3 CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL53074 194584 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 2 6 5.3 CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
44358503 27541 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 523 5 2 6 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3ccccc3S(=O)(=O)N2)cc1 10.1016/S0960-894X(01)81119-7
CHEMBL136911 27541 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 523 5 2 6 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3ccccc3S(=O)(=O)N2)cc1 10.1016/S0960-894X(01)81119-7
44288370 101118 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 418 7 1 3 5.5 CCCCC1=NC(=O)C2(CCCC2)CN1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81139-2
CHEMBL295181 101118 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 418 7 1 3 5.5 CCCCC1=NC(=O)C2(CCCC2)CN1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81139-2
10455118 116435 None 0 Guinea pig Binding pIC50 = 5.9 5.9 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 389 4 1 4 5.6 Cc1cc(/C=C/c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00100a007
CHEMBL336056 116435 None 0 Guinea pig Binding pIC50 = 5.9 5.9 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 389 4 1 4 5.6 Cc1cc(/C=C/c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00100a007
11757357 207990 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 552 9 1 6 5.8 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL97273 207990 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 552 9 1 6 5.8 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
19792113 188218 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 508 11 1 7 6.2 CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 10.1007/s00044-009-9182-z
CHEMBL49930 188218 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 508 11 1 7 6.2 CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 10.1007/s00044-009-9182-z
15355266 194584 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 2 6 5.3 CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL53074 194584 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 2 6 5.3 CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
19792097 101627 None 0 Bovine Binding pIC50 = 4.9 4.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 451 8 2 6 4.4 CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL298950 101627 None 0 Bovine Binding pIC50 = 4.9 4.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 451 8 2 6 4.4 CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
15654717 102642 None 0 Bovine Binding pIC50 = 4.9 4.9 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL304360 102642 None 0 Bovine Binding pIC50 = 4.9 4.9 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
19792097 101627 None 0 Bovine Binding pIC50 = 4.9 4.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 451 8 2 6 4.4 CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL298950 101627 None 0 Bovine Binding pIC50 = 4.9 4.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 451 8 2 6 4.4 CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
9894381 102038 None 0 Bovine Binding pIC50 = 6.9 6.9 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 574 8 1 7 7.0 CCCCc1nc2ccc(C3CCC4CCCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL301827 102038 None 0 Bovine Binding pIC50 = 6.9 6.9 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 574 8 1 7 7.0 CCCCc1nc2ccc(C3CCC4CCCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
164625885 186264 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4873899 186264 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
73352461 92626 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 469 9 2 4 5.9 CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
CHEMBL2435830 92626 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 469 9 2 4 5.9 CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
127035247 136517 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 549 9 2 5 7.0 CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3736338 136517 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 549 9 2 5 7.0 CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
19792093 101930 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 480 9 1 7 5.5 CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL301072 101930 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 480 9 1 7 5.5 CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
10030665 48873 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 558 12 2 8 5.7 CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL155948 48873 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 558 12 2 8 5.7 CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
10369225 49008 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 514 11 2 6 6.2 CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL156084 49008 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 514 11 2 6 6.2 CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
14956766 106977 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 471 7 1 7 4.5 CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL315128 106977 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 471 7 1 7 4.5 CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
1610 2345 None 95 Rat Binding pIC50 = 7.9 7.9 -1 4
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00074a018
3941 2345 None 95 Rat Binding pIC50 = 7.9 7.9 -1 4
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00074a018
3961 2345 None 95 Rat Binding pIC50 = 7.9 7.9 -1 4
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00074a018
590 2345 None 95 Rat Binding pIC50 = 7.9 7.9 -1 4
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00074a018
CHEMBL191 2345 None 95 Rat Binding pIC50 = 7.9 7.9 -1 4
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00074a018
DB00678 2345 None 95 Rat Binding pIC50 = 7.9 7.9 -1 4
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00074a018
10030665 48873 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 558 12 2 8 5.7 CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL155948 48873 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 558 12 2 8 5.7 CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
10369225 49008 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 514 11 2 6 6.2 CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL156084 49008 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 514 11 2 6 6.2 CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
10259265 110041 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 110041 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
15171393 85941 None 0 Guinea pig Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 447 7 1 5 5.7 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(Cc2ccccc2)c(C)n1 10.1021/jm00061a016
CHEMBL23006 85941 None 0 Guinea pig Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 447 7 1 5 5.7 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(Cc2ccccc2)c(C)n1 10.1021/jm00061a016
14950512 99825 None 0 Guinea pig Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 511 7 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(CC)n1 10.1021/jm00061a016
CHEMBL285560 99825 None 0 Guinea pig Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 511 7 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(CC)n1 10.1021/jm00061a016
44305409 202808 None 0 Bovine Binding pIC50 = 7.9 7.9 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 625 12 2 8 4.8 CCCc1cc(=O)n(CCNC(=O)C(c2ccccc2)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL62314 202808 None 0 Bovine Binding pIC50 = 7.9 7.9 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 625 12 2 8 4.8 CCCc1cc(=O)n(CCNC(=O)C(c2ccccc2)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
19385623 50433 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 10.1016/0960-894X(95)00185-V
CHEMBL15730 50433 None 0 Rabbit Binding pIC50 = 7.9 7.9 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 10.1016/0960-894X(95)00185-V
10371118 15514 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 586 13 0 8 5.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL121733 15514 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 586 13 0 8 5.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
10415119 118082 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 548 13 0 7 5.8 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2cccs2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL340605 118082 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 548 13 0 7 5.8 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2cccs2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
10030426 16619 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 548 13 0 7 5.8 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL124144 16619 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 548 13 0 7 5.8 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
1610 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2023.129349
3941 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2023.129349
3961 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2023.129349
590 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2023.129349
CHEMBL191 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2023.129349
DB00678 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2023.129349
44315304 205008 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL76821 205008 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
76319035 84977 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 541 11 3 8 5.4 CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237611 84977 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 541 11 3 8 5.4 CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
11511750 96553 None 1 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 483 10 2 6 4.6 CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00064a007
CHEMBL262958 96553 None 1 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 483 10 2 6 4.6 CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00064a007
44294051 174957 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 604 14 2 7 6.3 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2C)cc1 10.1021/jm00064a007
CHEMBL45659 174957 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 604 14 2 7 6.3 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2C)cc1 10.1021/jm00064a007
44294031 183962 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 532 12 2 5 6.1 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C)cc1 10.1021/jm00064a007
CHEMBL48168 183962 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 532 12 2 5 6.1 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C)cc1 10.1021/jm00064a007
44341713 9729 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 515 7 1 4 4.9 CCCCC1=NC2(CCN(C(=O)C(F)(F)F)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL113330 9729 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 515 7 1 4 4.9 CCCCC1=NC2(CCN(C(=O)C(F)(F)F)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
15171409 206289 None 0 Guinea pig Binding pIC50 = 6.9 6.9 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 441 7 1 6 5.0 CCc1cc(OCc2ccc(-c3ccc(OC)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
CHEMBL87034 206289 None 0 Guinea pig Binding pIC50 = 6.9 6.9 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 441 7 1 6 5.0 CCc1cc(OCc2ccc(-c3ccc(OC)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
44348042 16773 None 0 Bovine Binding pIC50 = 6.9 6.9 - 0
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 471 6 1 6 4.7 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCC2 10.1016/S0960-894X(01)80914-8
CHEMBL124449 16773 None 0 Bovine Binding pIC50 = 6.9 6.9 - 0
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 471 6 1 6 4.7 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCC2 10.1016/S0960-894X(01)80914-8
127028595 137365 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 616 11 3 7 5.9 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753047 137365 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 616 11 3 7 5.9 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
9986861 119681 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 498 10 2 7 5.8 CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL347236 119681 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 498 10 2 7 5.8 CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
44438868 92002 None 0 Bovine Binding pIC50 = 6.9 6.9 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 427 6 1 8 3.4 CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL241684 92002 None 0 Bovine Binding pIC50 = 6.9 6.9 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 427 6 1 8 3.4 CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
10412769 20249 None 0 Guinea pig Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 441 6 1 5 5.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(Cl)c2n1 10.1021/jm00100a007
CHEMBL130540 20249 None 0 Guinea pig Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 441 6 1 5 5.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(Cl)c2n1 10.1021/jm00100a007
10049787 22464 None 0 Guinea pig Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 421 6 1 5 5.5 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C)cc2n1 10.1021/jm00100a007
CHEMBL132509 22464 None 0 Guinea pig Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 421 6 1 5 5.5 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C)cc2n1 10.1021/jm00100a007
168288304 191369 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of human AT1R expressed in HEK293 cells by non-linear regression analysisInhibition of human AT1R expressed in HEK293 cells by non-linear regression analysis
ChEMBL 806 14 5 15 6.8 CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2cc(-c3oc4cc(O)cc(O)c4c(=O)c3O)ccc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2021.114068
CHEMBL5192190 191369 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of human AT1R expressed in HEK293 cells by non-linear regression analysisInhibition of human AT1R expressed in HEK293 cells by non-linear regression analysis
ChEMBL 806 14 5 15 6.8 CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2cc(-c3oc4cc(O)cc(O)c4c(=O)c3O)ccc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2021.114068
168293707 192163 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of human AT1R expressed in HEK293 cells by non-linear regression analysisInhibition of human AT1R expressed in HEK293 cells by non-linear regression analysis
ChEMBL 806 14 5 15 6.8 CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2ccc(-c3oc4cc(O)cc(O)c4c(=O)c3O)cc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2021.114068
CHEMBL5203983 192163 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of human AT1R expressed in HEK293 cells by non-linear regression analysisInhibition of human AT1R expressed in HEK293 cells by non-linear regression analysis
ChEMBL 806 14 5 15 6.8 CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2ccc(-c3oc4cc(O)cc(O)c4c(=O)c3O)cc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2021.114068
19385652 47516 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 459 9 1 6 5.3 CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15458 47516 None 0 Rabbit Binding pIC50 = 6.9 6.9 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 459 9 1 6 5.3 CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
10456700 119666 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 455 9 2 6 4.7 CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL347050 119666 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 455 9 2 6 4.7 CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44459583 93272 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 426 7 1 4 5.5 CCCCc1nc2c(C)cccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL24499 93272 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 426 7 1 4 5.5 CCCCc1nc2c(C)cccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(00)80334-0
15699069 5088 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 400 7 2 6 3.2 CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(c1nnn[nH]1)C2 10.1021/jm00114a021
CHEMBL105525 5088 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 400 7 2 6 3.2 CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(c1nnn[nH]1)C2 10.1021/jm00114a021
44285212 150459 None 1 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 546 7 1 5 6.3 O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(c2ccccc2)=NC1(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80526-6
CHEMBL39542 150459 None 1 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 546 7 1 5 6.3 O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(c2ccccc2)=NC1(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80526-6
10456700 119666 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 455 9 2 6 4.7 CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL347050 119666 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 455 9 2 6 4.7 CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
44563174 174418 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortexDisplacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex
ChEMBL 536 7 1 5 8.0 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc[nH]2)cc1 10.1016/j.bmc.2008.10.040
CHEMBL455286 174418 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortexDisplacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex
ChEMBL 536 7 1 5 8.0 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc[nH]2)cc1 10.1016/j.bmc.2008.10.040
19792093 101930 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 480 9 1 7 5.5 CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL301072 101930 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 480 9 1 7 5.5 CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
44303888 203277 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 552 12 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64674 203277 None 0 Rabbit Binding pIC50 = 5.9 5.9 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 552 12 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44298775 197646 None 0 Bovine Binding pIC50 = 4.9 4.9 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 410 5 1 7 3.1 COc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
CHEMBL57090 197646 None 0 Bovine Binding pIC50 = 4.9 4.9 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 410 5 1 7 3.1 COc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
10620305 10106 None 0 Bovine Binding pIC50 = 4.9 4.9 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 388 7 2 6 3.4 CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
CHEMBL115560 10106 None 0 Bovine Binding pIC50 = 4.9 4.9 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 388 7 2 6 3.4 CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
73349423 92618 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 441 7 2 4 5.7 CCCc1nc2c(C)cc(NC(C)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435822 92618 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 441 7 2 4 5.7 CCCc1nc2c(C)cc(NC(C)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
24828294 95825 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 411 7 1 7 4.3 CCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 10.1021/jm7011563
CHEMBL258891 95825 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 411 7 1 7 4.3 CCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 10.1021/jm7011563
44294052 101399 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 618 14 1 8 6.4 CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2C)cc1 10.1021/jm00064a007
CHEMBL297265 101399 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 618 14 1 8 6.4 CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2C)cc1 10.1021/jm00064a007
10347373 48534 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 544 12 3 7 5.6 CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL155661 48534 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 544 12 3 7 5.6 CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
11755714 120238 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 500 11 2 6 5.9 CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL352235 120238 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 500 11 2 6 5.9 CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
14956744 206161 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL86255 206161 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44459896 96275 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 470 7 1 6 5.3 CCCCc1nc2cc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL26113 96275 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 470 7 1 6 5.3 CCCCc1nc2cc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
10347373 48534 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 544 12 3 7 5.6 CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL155661 48534 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 544 12 3 7 5.6 CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
11755714 120238 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 500 11 2 6 5.9 CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL352235 120238 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 500 11 2 6 5.9 CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
44377263 164896 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 416 8 0 8 3.7 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL422200 164896 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 416 8 0 8 3.7 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 10.1016/S0960-894X(01)81124-0
10417195 109077 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321313 109077 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
44315058 70451 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL194608 70451 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44372814 119788 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 672 11 2 6 6.7 CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1021/jm9504722
CHEMBL348157 119788 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 672 11 2 6 6.7 CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1021/jm9504722
44320519 107171 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranesInhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranes
ChEMBL 495 7 1 7 4.6 CCCCc1ncc2n1[C@H](c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC[C@@H]2N1C(=O)CCC1=O 10.1016/S0960-894X(01)80290-0
CHEMBL316392 107171 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranesInhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranes
ChEMBL 495 7 1 7 4.6 CCCCc1ncc2n1[C@H](c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC[C@@H]2N1C(=O)CCC1=O 10.1016/S0960-894X(01)80290-0
44309299 102336 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 537 12 0 9 5.1 CCCCc1nn(CC(OCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn(C)n2)cc1 10.1021/jm00067a015
CHEMBL303683 102336 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 537 12 0 9 5.1 CCCCc1nn(CC(OCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn(C)n2)cc1 10.1021/jm00067a015
10223724 205755 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 417 9 1 7 3.7 CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL82797 205755 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 417 9 1 7 3.7 CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
14951062 206389 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 429 9 1 7 3.7 CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL87669 206389 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 429 9 1 7 3.7 CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
10411441 51788 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
CHEMBL15850 51788 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
44381431 58499 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 578 11 1 9 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168346 58499 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 578 11 1 9 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
53309273 63773 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 463 5 1 6 5.6 CCc1c(C)nc2c(nc(CC)n2[C@H]2CCc3cc(-c4ccccc4-c4nnn[nH]4)ccc32)c1C 10.1021/jm200409s
CHEMBL1801737 63773 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 463 5 1 6 5.6 CCc1c(C)nc2c(nc(CC)n2[C@H]2CCc3cc(-c4ccccc4-c4nnn[nH]4)ccc32)c1C 10.1021/jm200409s
10324179 114374 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 514 11 1 6 5.4 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL333126 114374 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 514 11 1 6 5.4 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 10.1007/s00044-009-9205-9
44342089 10043 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 442 7 0 6 4.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 10.1021/jm00074a018
CHEMBL115193 10043 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 442 7 0 6 4.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 10.1021/jm00074a018
44341702 10096 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 434 11 1 3 6.3 CCCCC1=NC(CCC)(CCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL115492 10096 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 434 11 1 3 6.3 CCCCC1=NC(CCC)(CCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
19976810 206352 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 416 10 1 7 4.3 CCCCc1nc(CCCC)n(Cc2ccc(-c3cnccc3-c3nn[nH]n3)cc2)n1 10.1021/jm031100t
CHEMBL87411 206352 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 416 10 1 7 4.3 CCCCc1nc(CCCC)n(Cc2ccc(-c3cnccc3-c3nn[nH]n3)cc2)n1 10.1021/jm031100t
1610 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00319-O
3941 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00319-O
3961 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00319-O
590 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00319-O
CHEMBL191 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00319-O
DB00678 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00319-O
19422654 101396 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 460 9 1 3 6.7 CCCCC1=NC(C)(CC2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL297250 101396 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 460 9 1 3 6.7 CCCCC1=NC(C)(CC2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
44297010 101625 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 577 8 1 10 4.1 CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL298943 101625 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 577 8 1 10 4.1 CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
19102815 207876 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL96554 207876 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
44296547 188337 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 380 7 3 5 3.1 CCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
CHEMBL50092 188337 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 380 7 3 5 3.1 CCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
2583 3774 None 118 Human Binding pIC50 = 6.8 6.8 - 1
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmc.2012.05.056
592 3774 None 118 Human Binding pIC50 = 6.8 6.8 - 1
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmc.2012.05.056
65999 3774 None 118 Human Binding pIC50 = 6.8 6.8 - 1
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmc.2012.05.056
CHEMBL1017 3774 None 118 Human Binding pIC50 = 6.8 6.8 - 1
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmc.2012.05.056
DB00966 3774 None 118 Human Binding pIC50 = 6.8 6.8 - 1
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmc.2012.05.056
1610 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00067a016
3941 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00067a016
3961 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00067a016
590 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00067a016
CHEMBL191 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00067a016
DB00678 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00067a016
15654750 103594 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 456 7 2 7 4.5 CSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL308651 103594 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 456 7 2 7 4.5 CSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
44563176 171442 None 0 Bovine Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortexDisplacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex
ChEMBL 537 7 1 6 7.4 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncn[nH]2)cc1 10.1016/j.bmc.2008.10.040
CHEMBL446314 171442 None 0 Bovine Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortexDisplacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex
ChEMBL 537 7 1 6 7.4 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncn[nH]2)cc1 10.1016/j.bmc.2008.10.040
19792183 101777 None 0 Bovine Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 442 7 1 5 5.9 CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL299994 101777 None 0 Bovine Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 442 7 1 5 5.9 CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
44210317 103209 None 0 Bovine Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 532 5 1 3 5.3 CCCCc1nc2ccccc2n1Cc1cc(I)c(O)c(I)c1 10.1016/S0960-894X(01)81149-5
CHEMBL308424 103209 None 0 Bovine Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 532 5 1 3 5.3 CCCCc1nc2ccccc2n1Cc1cc(I)c(O)c(I)c1 10.1016/S0960-894X(01)81149-5
14951055 204330 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 351 7 2 5 3.7 CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00067a015
CHEMBL71518 204330 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 351 7 2 5 3.7 CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00067a015
19792183 101777 None 0 Bovine Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 442 7 1 5 5.9 CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL299994 101777 None 0 Bovine Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 442 7 1 5 5.9 CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
127034757 136393 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 679 12 2 7 7.5 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735265 136393 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 679 12 2 7 7.5 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
127036104 136468 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 555 9 2 6 6.7 CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735910 136468 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 555 9 2 6 6.7 CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
127036294 136349 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 555 9 2 6 6.7 CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3734815 136349 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 555 9 2 6 6.7 CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
24828567 96300 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 410 6 1 5 4.4 CCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL261248 96300 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 410 6 1 5 4.4 CCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
44296953 194761 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 561 8 1 8 5.7 CCCCc1nc2ccc([C@H]3C4CCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL53803 194761 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 561 8 1 8 5.7 CCCCc1nc2ccc([C@H]3C4CCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
127035514 136421 None 0 Human Binding pIC50 = 6.8 6.8 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 585 11 2 7 6.3 CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735446 136421 None 0 Human Binding pIC50 = 6.8 6.8 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 585 11 2 7 6.3 CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
10094859 19988 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 441 8 1 4 5.8 CCCc1nc2c(C)cc(CN(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL130322 19988 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 441 8 1 4 5.8 CCCc1nc2c(C)cc(CN(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
10371295 113523 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 596 12 0 6 6.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(F)(F)F)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL332152 113523 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 596 12 0 6 6.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(F)(F)F)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
14956745 206267 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL86906 206267 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44307122 202994 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 349 3 1 4 4.7 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(O)c(Cl)c1 10.1016/S0960-894X(01)81148-3
CHEMBL63144 202994 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 349 3 1 4 4.7 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(O)c(Cl)c1 10.1016/S0960-894X(01)81148-3
9823146 19359 None 0 Human Binding pIC50 = 7.8 7.8 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 415 10 1 6 4.9 CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 10.1016/j.bmc.2010.10.043
CHEMBL12909 19359 None 0 Human Binding pIC50 = 7.8 7.8 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 415 10 1 6 4.9 CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 10.1016/j.bmc.2010.10.043
127035410 136383 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 557 8 1 8 5.7 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C#N)c1)C(=O)CCCC2 10.1039/C4MD00499J
CHEMBL3735155 136383 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 557 8 1 8 5.7 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C#N)c1)C(=O)CCCC2 10.1039/C4MD00499J
70692693 76213 None 0 Bovine Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 500 8 1 6 6.1 CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058369 76213 None 0 Bovine Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 500 8 1 6 6.1 CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
44438880 91984 None 0 Bovine Binding pIC50 = 7.8 7.8 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 427 7 2 7 3.7 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL241523 91984 None 0 Bovine Binding pIC50 = 7.8 7.8 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 427 7 2 7 3.7 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
44297143 101249 None 0 Bovine Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 547 8 1 8 5.3 CCCCc1nc2ccc([C@@H]3[C@H]4CCCN3OC4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL296173 101249 None 0 Bovine Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 547 8 1 8 5.3 CCCCc1nc2ccc([C@@H]3[C@H]4CCCN3OC4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
9886863 33917 None 0 Guinea pig Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 393 5 1 5 5.0 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00100a007
CHEMBL142380 33917 None 0 Guinea pig Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 393 5 1 5 5.0 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00100a007
10078800 109189 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 109189 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
9886863 33917 None 0 Guinea pig Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 393 5 1 5 5.0 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00061a016
CHEMBL142380 33917 None 0 Guinea pig Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 393 5 1 5 5.0 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00061a016
14951066 103057 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 489 9 1 9 3.6 CCCCc1nn(CC(=O)OC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL307310 103057 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 489 9 1 9 3.6 CCCCc1nn(CC(=O)OC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
10183373 165008 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 465 9 1 7 4.3 CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL422593 165008 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 465 9 1 7 4.3 CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
19811543 203369 None 0 Bovine Binding pIC50 = 7.8 7.8 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 444 9 1 7 3.7 CCCCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O 10.1016/0960-894X(95)00370-9
CHEMBL65224 203369 None 0 Bovine Binding pIC50 = 7.8 7.8 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 444 9 1 7 3.7 CCCCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O 10.1016/0960-894X(95)00370-9
19385586 49724 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 479 8 1 6 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
CHEMBL15669 49724 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 479 8 1 6 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
10049400 155438 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 449 8 1 5 5.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(94)00476-V
CHEMBL40381 155438 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 449 8 1 5 5.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(94)00476-V
44381603 59114 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 532 8 2 7 3.8 CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169798 59114 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 532 8 2 7 3.8 CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/S0960-894X(01)81126-4
1610 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1039/C5MD00169B
3941 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1039/C5MD00169B
3961 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1039/C5MD00169B
590 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1039/C5MD00169B
CHEMBL191 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1039/C5MD00169B
DB00678 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1039/C5MD00169B
1610 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2013.08.014
3941 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2013.08.014
3961 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2013.08.014
590 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2013.08.014
CHEMBL191 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2013.08.014
DB00678 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2013.08.014
1610 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
3941 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
3961 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
590 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
CHEMBL191 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
DB00678 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
1610 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
3941 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
3961 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
590 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
CHEMBL191 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
DB00678 2345 None 95 Human Binding pIC50 = 7.8 7.8 1 4
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
10323969 16406 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 507 9 0 8 4.3 CCCCc1ncc(/C=C2/C(=O)N(C)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL123091 16406 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 507 9 0 8 4.3 CCCCc1ncc(/C=C2/C(=O)N(C)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
70682146 76329 None 0 Human Binding pIC50 = 7.8 7.8 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL2058860 76329 None 0 Human Binding pIC50 = 7.8 7.8 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
10325767 113072 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 573 13 0 8 5.6 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL331219 113072 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 573 13 0 8 5.6 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
53309275 63775 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 463 5 1 6 5.8 CCc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 10.1021/jm200409s
CHEMBL1801739 63775 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 463 5 1 6 5.8 CCc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 10.1021/jm200409s
44306647 100902 None 0 Rabbit Binding pIC50 = 6.8 6.8 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 425 6 1 7 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81148-3
CHEMBL293846 100902 None 0 Rabbit Binding pIC50 = 6.8 6.8 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 425 6 1 7 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81148-3
127034756 136351 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 679 12 2 7 7.5 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3734829 136351 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 679 12 2 7 7.5 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
15780064 99621 None 0 Rabbit Binding pIC50 = 6.8 6.8 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 613 10 1 8 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL284123 99621 None 0 Rabbit Binding pIC50 = 6.8 6.8 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 613 10 1 8 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
1610 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortexDisplacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.040
3941 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortexDisplacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.040
3961 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortexDisplacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.040
590 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortexDisplacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.040
CHEMBL191 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortexDisplacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.040
DB00678 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortexDisplacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.040
44438901 91985 None 0 Bovine Binding pIC50 = 6.8 6.8 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 389 6 2 5 3.8 CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL241529 91985 None 0 Bovine Binding pIC50 = 6.8 6.8 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 389 6 2 5 3.8 CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
10390316 22014 None 0 Guinea pig Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 441 6 1 5 5.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(Cl)cc2n1 10.1021/jm00100a007
CHEMBL132115 22014 None 0 Guinea pig Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 441 6 1 5 5.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(Cl)cc2n1 10.1021/jm00100a007
9984310 21078 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 524 9 3 4 7.2 CCCCc1nc2cccc(NC(=O)NC3CCCCC3)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL131209 21078 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 524 9 3 4 7.2 CCCCc1nc2cccc(NC(=O)NC3CCCCC3)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
10367325 168408 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 467 8 1 4 6.8 CCCCc1nc2ccc(N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL434815 168408 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 467 8 1 4 6.8 CCCCc1nc2ccc(N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
1610 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00370-9
3941 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00370-9
3961 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00370-9
590 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00370-9
CHEMBL191 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00370-9
DB00678 2345 None 95 Bovine Binding pIC50 = 6.8 6.8 - 4
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00370-9
10096347 49413 None 0 Rabbit Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 472 9 2 6 5.4 CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL156449 49413 None 0 Rabbit Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 472 9 2 6 5.4 CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44298758 194152 None 0 Bovine Binding pIC50 = 5.8 5.8 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 452 7 1 7 4.2 CCCOc1nc2ccc(C)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
CHEMBL52824 194152 None 0 Bovine Binding pIC50 = 5.8 5.8 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 452 7 1 7 4.2 CCCOc1nc2ccc(C)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
44321129 111465 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranesDisplacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranes
ChEMBL 457 8 1 7 5.0 CCCCn1nc2n(c1=O)C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2CCC 10.1016/S0960-894X(01)80290-0
CHEMBL327614 111465 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranesDisplacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranes
ChEMBL 457 8 1 7 5.0 CCCCn1nc2n(c1=O)C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2CCC 10.1016/S0960-894X(01)80290-0
10096347 49413 None 0 Rabbit Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 472 9 2 6 5.4 CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL156449 49413 None 0 Rabbit Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 472 9 2 6 5.4 CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
54768660 65115 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 521 8 1 8 4.9 CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cccc(C)c1 10.1016/j.ejmech.2011.05.056
CHEMBL1824000 65115 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 521 8 1 8 4.9 CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cccc(C)c1 10.1016/j.ejmech.2011.05.056
44309040 102985 None 0 Bovine Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 370 7 1 7 3.9 CCCCc1nc2ccccc2n1Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)81149-5
CHEMBL306670 102985 None 0 Bovine Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 370 7 1 7 3.9 CCCCc1nc2ccccc2n1Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)81149-5
44459707 93355 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortexConcentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortex
ChEMBL 518 8 2 7 5.1 CCCCc1nc2cc(C3=NNC(=O)CC3C)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
CHEMBL24550 93355 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortexConcentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortex
ChEMBL 518 8 2 7 5.1 CCCCc1nc2cc(C3=NNC(=O)CC3C)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
127028618 137275 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 536 9 3 7 4.9 CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752198 137275 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 536 9 3 7 4.9 CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
127034903 136436 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 571 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735641 136436 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 571 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
24827902 157731 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 459 7 1 7 4.5 CCCCn1c(=O)c2ccc(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL408227 157731 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 459 7 1 7 4.5 CCCCn1c(=O)c2ccc(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
76325126 105243 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 531 10 2 4 7.1 CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmcl.2014.01.004
CHEMBL3115241 105243 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 531 10 2 4 7.1 CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmcl.2014.01.004
71653152 89150 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 593 11 2 7 5.9 CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2337682 89150 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 593 11 2 7 5.9 CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2365924 89150 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 593 11 2 7 5.9 CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
76311800 84956 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 538 11 2 8 5.7 CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237590 84956 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 538 11 2 8 5.7 CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
14956784 106555 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 447 9 1 9 2.5 CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL314179 106555 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 447 9 1 9 2.5 CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
14956764 206075 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 541 8 1 7 5.0 CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL85541 206075 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 541 8 1 7 5.0 CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
11316515 206190 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 436 5 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 10.1021/jm031100t
CHEMBL86437 206190 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 436 5 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 10.1021/jm031100t
9889557 97051 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 442 7 3 7 2.7 CCCCc1nc2c(=O)[nH][nH]c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL267056 97051 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 442 7 3 7 2.7 CCCCc1nc2c(=O)[nH][nH]c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
10028751 164914 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 495 10 1 7 6.1 CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL422333 164914 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 495 10 1 7 6.1 CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
10010164 117395 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339806 117395 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
14951070 203867 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 489 13 2 8 3.9 CCCCc1nn(CCCCCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL68731 203867 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 489 13 2 8 3.9 CCCCc1nn(CCCCCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
9930953 102800 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 402 6 1 7 2.4 CCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL305350 102800 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 402 6 1 7 2.4 CCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
10393086 16515 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 562 12 0 6 6.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL123670 16515 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 562 12 0 6 6.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
11758470 113009 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 612 12 0 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Br)s2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL331121 113009 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 612 12 0 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Br)s2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
15780091 120994 None 0 Rabbit Binding pIC50 = 6.8 6.8 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 618 9 1 8 6.1 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL35638 120994 None 0 Rabbit Binding pIC50 = 6.8 6.8 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 618 9 1 8 6.1 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
9982960 119845 None 0 Rabbit Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 488 8 1 7 5.7 CCCCc1nn2c(-c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL348616 119845 None 0 Rabbit Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 488 8 1 7 5.7 CCCCc1nn2c(-c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
10475047 117443 None 0 Guinea pig Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 383 6 1 3 5.7 CCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 10.1021/jm00100a007
CHEMBL339846 117443 None 0 Guinea pig Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 383 6 1 3 5.7 CCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 10.1021/jm00100a007
10141058 203791 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 487 14 1 7 5.6 CCCCCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O 10.1021/jm00067a015
CHEMBL68275 203791 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 487 14 1 7 5.6 CCCCCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O 10.1021/jm00067a015
10161446 102771 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 456 7 2 7 4.7 CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL305190 102771 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 456 7 2 7 4.7 CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
15654758 203845 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 425 6 3 7 3.7 CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL68597 203845 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 425 6 3 7 3.7 CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
15654742 204067 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 438 7 2 6 4.6 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL70074 204067 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 438 7 2 6 4.6 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
19385675 51372 None 0 Rabbit Binding pIC50 = 6.8 6.8 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 445 8 1 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
CHEMBL15816 51372 None 0 Rabbit Binding pIC50 = 6.8 6.8 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 445 8 1 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
10004159 119548 None 0 Rabbit Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 455 9 2 6 4.7 CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL345894 119548 None 0 Rabbit Binding pIC50 = 5.8 5.8 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 455 9 2 6 4.7 CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44291830 178669 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 462 13 1 3 7.1 CCCCC1=NC(CCCC)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL46782 178669 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 462 13 1 3 7.1 CCCCC1=NC(CCCC)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
10004159 119548 None 0 Rabbit Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 455 9 2 6 4.7 CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL345894 119548 None 0 Rabbit Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 455 9 2 6 4.7 CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
44291830 178669 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 462 13 1 3 7.1 CCCCC1=NC(CCCC)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL46782 178669 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 462 13 1 3 7.1 CCCCC1=NC(CCCC)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
11741660 117143 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 399 7 2 4 5.4 CCCCc1nc2c(N)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL339360 117143 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 399 7 2 4 5.4 CCCCc1nc2c(N)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
4823 93560 None 91 Bovine Binding pIC50 = 4.8 4.8 - 0
Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortexConcentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortex
ChEMBL 334 3 2 4 3.1 COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 10.1016/S0960-894X(01)80348-6
CHEMBL24646 93560 None 91 Bovine Binding pIC50 = 4.8 4.8 - 0
Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortexConcentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortex
ChEMBL 334 3 2 4 3.1 COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 10.1016/S0960-894X(01)80348-6
164620345 186211 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4873167 186211 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
44296955 194673 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 653 10 1 10 5.7 CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL53226 194673 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 653 10 1 10 5.7 CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
14956741 107052 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL315615 107052 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44341731 10196 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 461 7 1 4 4.4 CCCCC1=NC2(CCN(C(C)=O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL115984 10196 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 461 7 1 4 4.4 CCCCC1=NC2(CCN(C(C)=O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
19889373 206175 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 410 5 1 7 3.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 10.1021/jm031100t
CHEMBL86346 206175 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 410 5 1 7 3.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 10.1021/jm031100t
1610 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80295-X
3941 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80295-X
3961 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80295-X
590 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80295-X
CHEMBL191 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80295-X
DB00678 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80295-X
CHEMBL5271135 193669 None 0 Human Binding pIC50 = 7.8 7.8 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 391 4 1 4 4.6 Cc1ccc(S(=O)(=O)n2c(-c3ccccc3)c(C(=O)O)c3ccccc32)cc1 10.1016/j.bmcl.2023.129349
24827770 95878 None 0 Rat Binding pIC50 = 7.8 7.8 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 425 7 1 7 3.9 CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL259114 95878 None 0 Rat Binding pIC50 = 7.8 7.8 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 425 7 1 7 3.9 CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
19422638 174214 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 404 8 1 3 5.2 CCCCC1=NC(C)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL45485 174214 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 404 8 1 3 5.2 CCCCC1=NC(C)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
1610 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00100a007
3941 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00100a007
3961 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00100a007
590 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00100a007
CHEMBL191 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00100a007
DB00678 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00100a007
10099830 108489 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 584 9 1 7 4.9 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
CHEMBL319955 108489 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 584 9 1 7 4.9 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
44315349 60388 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL17487 60388 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
1610 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00061a016
3941 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00061a016
3961 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00061a016
590 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00061a016
CHEMBL191 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00061a016
DB00678 2345 None 95 Guinea pig Binding pIC50 = 7.8 7.8 - 4
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00061a016
10140958 103007 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 485 10 1 7 5.3 CCCCc1nn(CCC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL306882 103007 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 485 10 1 7 5.3 CCCCc1nn(CCC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
14956804 105997 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 493 11 1 7 4.9 CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL313222 105997 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 493 11 1 7 4.9 CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
15287891 123689 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 459 10 1 6 5.3 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OCC)cc1 10.1016/0960-894X(94)00476-V
CHEMBL36218 123689 None 0 Rabbit Binding pIC50 = 7.8 7.8 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 459 10 1 6 5.3 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OCC)cc1 10.1016/0960-894X(94)00476-V
10007528 16291 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 542 12 0 6 6.0 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(C)c2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL122490 16291 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 542 12 0 6 6.0 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(C)c2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
44277595 6322 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 621 9 0 10 5.4 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CC(=O)c4ccco4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL108190 6322 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 621 9 0 10 5.4 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CC(=O)c4ccco4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
44294996 189791 None 0 Bovine Binding pIC50 = 6.8 6.8 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 501 10 1 6 5.7 CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(00)80474-6
CHEMBL51622 189791 None 0 Bovine Binding pIC50 = 6.8 6.8 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 501 10 1 6 5.7 CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(00)80474-6
44293657 175655 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 534 12 3 6 5.3 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
CHEMBL45814 175655 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 534 12 3 6 5.3 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
44293954 187697 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 554 12 3 7 5.6 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
CHEMBL49526 187697 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 554 12 3 7 5.6 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
44296985 194401 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 603 8 1 8 6.9 CCCCc1nc2ccc([C@H]3C4CCCCCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL52880 194401 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 603 8 1 8 6.9 CCCCc1nc2ccc([C@H]3C4CCCCCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
10453972 22185 None 0 Guinea pig Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 369 5 1 3 5.5 Cc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 10.1021/jm00100a007
CHEMBL132269 22185 None 0 Guinea pig Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 369 5 1 3 5.5 Cc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 10.1021/jm00100a007
14951081 203690 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 581 14 1 10 4.6 CCCCc1nn(CC(OCC(=O)OCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL67515 203690 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 581 14 1 10 4.6 CCCCc1nn(CC(OCC(=O)OCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
10366029 115209 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 441 8 2 4 5.8 CCCCc1nc2ccc(NC(C)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL334515 115209 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 441 8 2 4 5.8 CCCCc1nc2ccc(NC(C)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
44381714 59119 None 0 Rabbit Binding pIC50 = 6.8 6.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 732 11 1 7 7.6 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169827 59119 None 0 Rabbit Binding pIC50 = 6.8 6.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 732 11 1 7 7.6 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
44341801 9800 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 404 7 1 3 5.3 CCCCC1=NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL113701 9800 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 404 7 1 3 5.3 CCCCC1=NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
44341772 110590 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 418 7 0 4 5.4 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)OC)cc1 10.1021/jm00074a018
CHEMBL325502 110590 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 418 7 0 4 5.4 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)OC)cc1 10.1021/jm00074a018
44321129 111465 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranesDisplacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranes
ChEMBL 457 8 1 7 5.0 CCCCn1nc2n(c1=O)C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2CCC 10.1016/S0960-894X(01)80290-0
CHEMBL327614 111465 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranesDisplacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranes
ChEMBL 457 8 1 7 5.0 CCCCn1nc2n(c1=O)C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2CCC 10.1016/S0960-894X(01)80290-0
10026315 116102 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 441 8 2 4 5.8 CCCCc1nc2cccc(NC(C)=O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL335734 116102 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 441 8 2 4 5.8 CCCCc1nc2cccc(NC(C)=O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
24827899 96887 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 411 5 1 7 3.4 CCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL265697 96887 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 411 5 1 7 3.4 CCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
1610 2345 None 95 Rat Binding pIC50 = 7.7 7.7 -1 4
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00092a017
3941 2345 None 95 Rat Binding pIC50 = 7.7 7.7 -1 4
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00092a017
3961 2345 None 95 Rat Binding pIC50 = 7.7 7.7 -1 4
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00092a017
590 2345 None 95 Rat Binding pIC50 = 7.7 7.7 -1 4
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00092a017
CHEMBL191 2345 None 95 Rat Binding pIC50 = 7.7 7.7 -1 4
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00092a017
DB00678 2345 None 95 Rat Binding pIC50 = 7.7 7.7 -1 4
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00092a017
44348302 16489 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm00075a033
CHEMBL123562 16489 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm00075a033
44438870 92003 None 0 Bovine Binding pIC50 = 7.7 7.7 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 469 9 1 8 4.6 CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL241685 92003 None 0 Bovine Binding pIC50 = 7.7 7.7 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 469 9 1 8 4.6 CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
44291438 183829 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 440 8 1 3 5.9 CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL48062 183829 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 440 8 1 3 5.9 CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
44348302 16489 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm9504722
CHEMBL123562 16489 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm9504722
1610 2345 None 95 Rat Binding pIC50 = 7.7 7.7 -1 4
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.03.028
3941 2345 None 95 Rat Binding pIC50 = 7.7 7.7 -1 4
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.03.028
3961 2345 None 95 Rat Binding pIC50 = 7.7 7.7 -1 4
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.03.028
590 2345 None 95 Rat Binding pIC50 = 7.7 7.7 -1 4
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.03.028
CHEMBL191 2345 None 95 Rat Binding pIC50 = 7.7 7.7 -1 4
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.03.028
DB00678 2345 None 95 Rat Binding pIC50 = 7.7 7.7 -1 4
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.03.028
71521299 86822 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 479 6 1 7 4.8 CCc1nc2ccn(CC(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322441 86822 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 479 6 1 7 4.8 CCc1nc2ccn(CC(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
127036102 136512 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 531 9 2 4 7.2 CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3736295 136512 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 531 9 2 4 7.2 CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL5075338 214366 None 0 Human Binding pIC50 = 7.7 7.7 - 1
Displacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassayDisplacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassay
ChEMBL None None None CCOC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@@H](C)NC(=O)/C=C/c1ccc(O)c(O)c1 10.1021/acs.jmedchem.1c00123
70686409 76324 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 571 10 2 7 6.1 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058855 76324 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 571 10 2 7 6.1 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
71521196 86820 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 571 8 1 9 4.9 CCc1nc2ccn(CC(=O)OCc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322439 86820 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 571 8 1 9 4.9 CCc1nc2ccn(CC(=O)OCc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
10098452 51438 None 0 Rabbit Binding pIC50 = 6.7 6.7 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 528 12 2 7 5.6 CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL158209 51438 None 0 Rabbit Binding pIC50 = 6.7 6.7 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 528 12 2 7 5.6 CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44341651 110481 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 406 7 2 3 4.8 CCCCC1NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL324785 110481 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 406 7 2 3 4.8 CCCCC1NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
10098452 51438 None 0 Rabbit Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 528 12 2 7 5.6 CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL158209 51438 None 0 Rabbit Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 528 12 2 7 5.6 CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
15231798 206440 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranesInhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranes
ChEMBL 452 9 1 5 6.4 CCCCc1nc(CCCC)n2c1C=CCC2c1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80290-0
CHEMBL88014 206440 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranesInhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranes
ChEMBL 452 9 1 5 6.4 CCCCc1nc(CCCC)n2c1C=CCC2c1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80290-0
14950502 85633 None 0 Guinea pig Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 385 6 1 6 3.9 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C=O)c(C)n1 10.1021/jm00061a016
CHEMBL22837 85633 None 0 Guinea pig Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 385 6 1 6 3.9 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C=O)c(C)n1 10.1021/jm00061a016
15654756 102397 None 0 Bovine Binding pIC50 = 6.7 6.7 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 454 8 2 7 4.4 CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL303955 102397 None 0 Bovine Binding pIC50 = 6.7 6.7 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 454 8 2 7 4.4 CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
15654741 203982 None 0 Bovine Binding pIC50 = 6.7 6.7 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 410 5 2 6 3.9 Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL69522 203982 None 0 Bovine Binding pIC50 = 6.7 6.7 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 410 5 2 6 3.9 Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
22596780 204398 None 1 Bovine Binding pIC50 = 6.7 6.7 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 416 7 2 5 4.5 CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00067a016
CHEMBL71954 204398 None 1 Bovine Binding pIC50 = 6.7 6.7 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 416 7 2 5 4.5 CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00067a016
10321914 120046 None 0 Rabbit Binding pIC50 = 5.7 5.7 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 458 8 2 6 5.1 CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL350446 120046 None 0 Rabbit Binding pIC50 = 5.7 5.7 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 458 8 2 6 5.1 CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
10321914 120046 None 0 Rabbit Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 458 8 2 6 5.1 CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL350446 120046 None 0 Rabbit Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 458 8 2 6 5.1 CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
54768661 65116 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 535 8 1 8 5.3 CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cc(C)cc(C)c1 10.1016/j.ejmech.2011.05.056
CHEMBL1824001 65116 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 535 8 1 8 5.3 CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cc(C)cc(C)c1 10.1016/j.ejmech.2011.05.056
44293991 101678 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 532 12 1 6 5.9 CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2)cc1 10.1021/jm00064a007
CHEMBL299324 101678 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 532 12 1 6 5.9 CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2)cc1 10.1021/jm00064a007
11757216 16618 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 547 12 0 8 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c(C)noc2C)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL124141 16618 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 547 12 0 8 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c(C)noc2C)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
57380649 70373 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 549 10 2 4 6.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945149 70373 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 549 10 2 4 6.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
2121583 23374 None 8 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 397 7 1 4 4.0 CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O 10.1016/j.bmc.2016.07.047
CHEMBL1332729 23374 None 8 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 397 7 1 4 4.0 CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O 10.1016/j.bmc.2016.07.047
2121583 23374 None 8 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 397 7 1 4 4.0 CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O 10.1016/j.bmc.2016.07.047
CHEMBL1332729 23374 None 8 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 397 7 1 4 4.0 CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O 10.1016/j.bmc.2016.07.047
44274672 91552 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 465 8 2 7 4.7 CCCCc1nc2ccc(NC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL24053 91552 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 465 8 2 7 4.7 CCCCc1nc2ccc(NC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
44274824 99261 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 535 11 2 7 5.8 CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(00)80335-2
CHEMBL281846 99261 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 535 11 2 7 5.8 CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(00)80335-2
14956756 206369 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 529 8 1 7 5.0 CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL87513 206369 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 529 8 1 7 5.0 CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
2583 3774 None 118 Human Binding pIC50 = 8.7 8.7 - 1
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmcl.2014.01.004
592 3774 None 118 Human Binding pIC50 = 8.7 8.7 - 1
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmcl.2014.01.004
65999 3774 None 118 Human Binding pIC50 = 8.7 8.7 - 1
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmcl.2014.01.004
CHEMBL1017 3774 None 118 Human Binding pIC50 = 8.7 8.7 - 1
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmcl.2014.01.004
DB00966 3774 None 118 Human Binding pIC50 = 8.7 8.7 - 1
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmcl.2014.01.004
136401481 160836 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 651 11 1 11 5.7 CCc1cc2c(=O)n(C/C(=N\OC(C)C)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
CHEMBL4114737 160836 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 651 11 1 11 5.7 CCc1cc2c(=O)n(C/C(=N\OC(C)C)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 nan
44274824 99261 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 535 11 2 7 5.8 CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(00)80334-0
CHEMBL281846 99261 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 535 11 2 7 5.8 CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(00)80334-0
44311583 204118 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL70353 204118 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10209324 14488 None 0 Human Binding pIC50 = 8.7 8.7 - 1
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 546 8 1 7 6.2 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 10.1039/C4MD00499J
CHEMBL12013 14488 None 0 Human Binding pIC50 = 8.7 8.7 - 1
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 546 8 1 7 6.2 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 10.1039/C4MD00499J
9871837 15201 None 0 Human Binding pIC50 = 8.7 8.7 - 1
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 535 10 2 7 4.9 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1039/C4MD00499J
CHEMBL12106 15201 None 0 Human Binding pIC50 = 8.7 8.7 - 1
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 535 10 2 7 4.9 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1039/C4MD00499J
15222070 102295 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 577 9 2 9 3.8 CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL303426 102295 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 577 9 2 9 3.8 CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311662 102679 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 624 17 2 7 5.8 CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC 10.1016/S0960-894X(00)80076-1
CHEMBL304620 102679 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 624 17 2 7 5.8 CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC 10.1016/S0960-894X(00)80076-1
15222094 102972 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 596 10 2 8 5.4 CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306489 102972 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 596 10 2 8 5.4 CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311681 103021 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 592 11 2 9 4.8 CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306961 103021 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 592 11 2 9 4.8 CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222092 103822 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 564 10 2 10 3.5 CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309165 103822 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 564 10 2 10 3.5 CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311451 104100 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 576 10 2 8 5.1 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309367 104100 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 576 10 2 8 5.1 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311497 167855 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 547 10 1 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL430997 167855 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 547 10 1 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311663 204187 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 561 10 2 7 5.8 CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70796 204187 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 561 10 2 7 5.8 CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311499 204397 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 557 17 2 7 6.6 CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
CHEMBL71953 204397 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 557 17 2 7 6.6 CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
44311648 204525 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 577 11 2 9 4.5 CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL72721 204525 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 577 11 2 9 4.5 CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311758 204669 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 626 12 3 7 6.7 CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL73780 204669 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 626 12 3 7 6.7 CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
19742811 57419 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL165354 57419 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
10077555 207408 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 10.1021/jm00043a020
CHEMBL93956 207408 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 10.1021/jm00043a020
10440144 116892 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338342 116892 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315349 60388 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL17487 60388 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
2583 3774 None 118 Human Binding pIC50 = 8.7 8.7 - 1
Inhibition of AT1 receptor (unknown origin)Inhibition of AT1 receptor (unknown origin)
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2019.04.030
592 3774 None 118 Human Binding pIC50 = 8.7 8.7 - 1
Inhibition of AT1 receptor (unknown origin)Inhibition of AT1 receptor (unknown origin)
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2019.04.030
65999 3774 None 118 Human Binding pIC50 = 8.7 8.7 - 1
Inhibition of AT1 receptor (unknown origin)Inhibition of AT1 receptor (unknown origin)
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2019.04.030
CHEMBL1017 3774 None 118 Human Binding pIC50 = 8.7 8.7 - 1
Inhibition of AT1 receptor (unknown origin)Inhibition of AT1 receptor (unknown origin)
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2019.04.030
DB00966 3774 None 118 Human Binding pIC50 = 8.7 8.7 - 1
Inhibition of AT1 receptor (unknown origin)Inhibition of AT1 receptor (unknown origin)
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2019.04.030
108185 1612 None 78 Human Binding pIC50 = 8.7 8.7 - 1
Inhibition of ATR1 (unknown origin)Inhibition of ATR1 (unknown origin)
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/acs.jmedchem.9b00179
586 1612 None 78 Human Binding pIC50 = 8.7 8.7 - 1
Inhibition of ATR1 (unknown origin)Inhibition of ATR1 (unknown origin)
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/acs.jmedchem.9b00179
CHEMBL907 1612 None 78 Human Binding pIC50 = 8.7 8.7 - 1
Inhibition of ATR1 (unknown origin)Inhibition of ATR1 (unknown origin)
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/acs.jmedchem.9b00179
1037 1576 None 69 Human Binding pIC50 = 8.7 8.7 - 1
Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
3940 1576 None 69 Human Binding pIC50 = 8.7 8.7 - 1
Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
5281037 1576 None 69 Human Binding pIC50 = 8.7 8.7 - 1
Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
588 1576 None 69 Human Binding pIC50 = 8.7 8.7 - 1
Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
CHEMBL813 1576 None 69 Human Binding pIC50 = 8.7 8.7 - 1
Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
DB00876 1576 None 69 Human Binding pIC50 = 8.7 8.7 - 1
Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
44285372 100289 None 0 Human Binding pIC50 = 8.7 8.7 - 0
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 1 siteThe compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 1 site
ChEMBL 446 6 1 6 4.3 CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL289105 100289 None 0 Human Binding pIC50 = 8.7 8.7 - 0
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 1 siteThe compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 1 site
ChEMBL 446 6 1 6 4.3 CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
44338666 110956 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 9 1 8 5.5 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL326217 110956 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 9 1 8 5.5 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
9850834 154660 None 17 Rabbit Binding pIC50 = 8.7 8.7 - 1
Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL39959 154660 None 17 Rabbit Binding pIC50 = 8.7 8.7 - 1
Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
14956779 68661 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 445 8 1 7 4.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL19202 68661 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 445 8 1 7 4.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81132-X
10031067 100350 None 4 Human Binding pIC50 = 8.7 8.7 - 3
Displacement of [125I]-[Sar1,Leu8]angiotensin II from human AT1 receptor expressed in african green monkey COS7 cellsDisplacement of [125I]-[Sar1,Leu8]angiotensin II from human AT1 receptor expressed in african green monkey COS7 cells
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
CHEMBL289614 100350 None 4 Human Binding pIC50 = 8.7 8.7 - 3
Displacement of [125I]-[Sar1,Leu8]angiotensin II from human AT1 receptor expressed in african green monkey COS7 cellsDisplacement of [125I]-[Sar1,Leu8]angiotensin II from human AT1 receptor expressed in african green monkey COS7 cells
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
127030943 139193 None 0 Human Binding pIC50 = 8.7 8.7 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787243 139193 None 0 Human Binding pIC50 = 8.7 8.7 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787375 139193 None 0 Human Binding pIC50 = 8.7 8.7 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787700 139193 None 0 Human Binding pIC50 = 8.7 8.7 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
44277462 14770 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 665 11 2 10 5.2 CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL1206522 14770 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 665 11 2 10 5.2 CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL281890 14770 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 665 11 2 10 5.2 CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
44277548 99408 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 615 12 0 10 4.6 COCCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL282777 99408 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 615 12 0 10 4.6 COCCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
10479475 115224 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 462 6 1 6 4.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1021/jm00050a002
CHEMBL334670 115224 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 462 6 1 6 4.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1021/jm00050a002
44288322 155199 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 470 7 1 5 5.8 CCCCC1=NC2(CCCC2)C(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81139-2
CHEMBL40251 155199 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 470 7 1 5 5.8 CCCCC1=NC2(CCCC2)C(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81139-2
10393837 167942 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 602 10 1 8 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 10.1021/jm00043a020
CHEMBL431619 167942 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 602 10 1 8 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 10.1021/jm00043a020
10462573 117007 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338889 117007 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10372550 164514 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL421478 164514 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315344 105079 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL311386 105079 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
18950607 50416 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 489 9 1 5 6.2 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15729 50416 None 0 Rabbit Binding pIC50 = 8.7 8.7 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 489 9 1 5 6.2 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
10004646 17951 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 464 9 2 6 4.1 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL126037 17951 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 464 9 2 6 4.1 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
136052253 124522 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 624 10 1 11 4.7 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3OC)c2s1 nan
CHEMBL3640160 124522 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
ChEMBL 624 10 1 11 4.7 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3OC)c2s1 nan
44278118 96984 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 587 9 0 8 5.9 CCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL266480 96984 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 587 9 0 8 5.9 CCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
44277737 100620 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 627 11 0 10 5.3 CCOC(=O)CCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL29192 100620 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 627 11 0 10 5.3 CCOC(=O)CCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
44315180 102894 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305956 102894 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
44315059 204710 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74144 204710 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315057 204827 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL75401 204827 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
19802473 198703 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 415 5 1 7 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL58156 198703 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 415 5 1 7 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81145-8
44305267 203399 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 536 9 1 9 3.7 CCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL65503 203399 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 536 9 1 9 3.7 CCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
10101582 119374 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 747 15 2 8 7.4 CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 10.1007/s00044-013-0831-x
CHEMBL344466 119374 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 747 15 2 8 7.4 CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 10.1007/s00044-013-0831-x
9979771 17444 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 424 10 2 5 3.7 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL125766 17444 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 424 10 2 5 3.7 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
9935106 65280 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL18287 65280 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44338708 110442 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.0 CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
CHEMBL324629 110442 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.0 CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
44277443 100296 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 583 10 0 8 6.0 CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL28918 100296 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 583 10 0 8 6.0 CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL938 215905 None 28 Rat Binding pIC50 = 8.6 8.6 - 2
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm00074a018
9935106 65280 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL18287 65280 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81132-X
57380412 70526 None 0 Human Binding pIC50 = 8.6 8.6 - 1
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947129 70526 None 0 Human Binding pIC50 = 8.6 8.6 - 1
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
44303230 200645 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL59957 200645 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
10349506 208057 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 10.1021/jm00043a020
CHEMBL97615 208057 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 10.1021/jm00043a020
44305681 102625 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 550 10 1 9 4.1 CCCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL304251 102625 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 550 10 1 9 4.1 CCCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
10101582 119374 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 747 15 2 8 7.4 CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 10.1021/jm00052a006
CHEMBL344466 119374 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 747 15 2 8 7.4 CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 10.1021/jm00052a006
76333687 85257 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 506 11 1 6 5.0 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C2(C(=O)OC)CCCC2)cc1 10.1007/s00044-009-9205-9
CHEMBL2259779 85257 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 506 11 1 6 5.0 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C2(C(=O)OC)CCCC2)cc1 10.1007/s00044-009-9205-9
15231091 93986 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL24861 93986 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
44338697 109657 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 613 11 1 8 6.8 CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
CHEMBL322471 109657 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 613 11 1 8 6.8 CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
44277738 100184 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 589 7 0 8 6.3 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(C(=O)c4ccccc4)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL28816 100184 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 589 7 0 8 6.3 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(C(=O)c4ccccc4)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
76324571 103979 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding affinity to AT1 receptor (unknown origin)Binding affinity to AT1 receptor (unknown origin)
ChEMBL 378 7 1 8 1.9 CCCCc1nn(C)c(=O)n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2013.10.017
CHEMBL3092993 103979 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding affinity to AT1 receptor (unknown origin)Binding affinity to AT1 receptor (unknown origin)
ChEMBL 378 7 1 8 1.9 CCCCc1nn(C)c(=O)n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2013.10.017
9939191 98944 None 1 Human Binding pIC50 = 8.6 8.6 - 1
In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from human adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from human adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL279629 98944 None 1 Human Binding pIC50 = 8.6 8.6 - 1
In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from human adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from human adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL97539 98944 None 1 Human Binding pIC50 = 8.6 8.6 - 1
In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from human adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from human adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
15231091 93986 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL24861 93986 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
10095986 16491 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 464 9 2 6 4.1 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL123568 16491 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 464 9 2 6 4.1 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
44277901 101390 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 585 10 1 9 4.7 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCCO)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL29722 101390 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 585 10 1 9 4.7 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCCO)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
11764669 66818 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 634 10 1 7 6.5 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL18606 66818 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 634 10 1 7 6.5 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
46910495 76330 None 0 Human Binding pIC50 = 8.6 8.6 - 1
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 585 11 2 7 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058861 76330 None 0 Human Binding pIC50 = 8.6 8.6 - 1
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 585 11 2 7 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
54578725 65125 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 403 8 3 7 4.0 CCCCn1ncc(C(=O)O)c1Nc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2011.05.056
CHEMBL1824184 65125 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 403 8 3 7 4.0 CCCCn1ncc(C(=O)O)c1Nc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2011.05.056
44211506 57539 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 557 10 1 6 5.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL166338 57539 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 557 10 1 6 5.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
44376780 56502 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 509 10 1 7 4.1 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL163486 56502 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 509 10 1 7 4.1 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
10349845 11360 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 708 10 1 8 7.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 10.1021/jm00043a020
CHEMBL1179731 11360 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 708 10 1 8 7.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 10.1021/jm00043a020
CHEMBL97271 11360 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 708 10 1 8 7.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 10.1021/jm00043a020
11764669 66818 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.5 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL18606 66818 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.5 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10054753 208144 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 629 9 2 7 5.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL98140 208144 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 629 9 2 7 5.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
135723840 139140 None 0 Rat Binding pIC50 = 8.6 8.6 - 1
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 452 8 2 6 4.6 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmc.2016.03.028
CHEMBL3787059 139140 None 0 Rat Binding pIC50 = 8.6 8.6 - 1
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 452 8 2 6 4.6 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmc.2016.03.028
9984303 17595 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 524 11 2 7 4.8 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9205-9
CHEMBL125818 17595 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 524 11 2 7 4.8 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9205-9
127035264 136504 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 601 11 2 7 7.3 CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3736244 136504 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 601 11 2 7 7.3 CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
183134 204842 None 17 Human Binding pIC50 = 8.6 8.6 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm200409s
CHEMBL7550 204842 None 17 Human Binding pIC50 = 8.6 8.6 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm200409s
2806 3967 None 110 Human Binding pIC50 = 8.6 8.6 - 1
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1016/S0960-894X(01)81117-3
3937 3967 None 110 Human Binding pIC50 = 8.6 8.6 - 1
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1016/S0960-894X(01)81117-3
593 3967 None 110 Human Binding pIC50 = 8.6 8.6 - 1
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1016/S0960-894X(01)81117-3
60846 3967 None 110 Human Binding pIC50 = 8.6 8.6 - 1
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1016/S0960-894X(01)81117-3
CHEMBL1069 3967 None 110 Human Binding pIC50 = 8.6 8.6 - 1
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1016/S0960-894X(01)81117-3
DB00177 3967 None 110 Human Binding pIC50 = 8.6 8.6 - 1
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1016/S0960-894X(01)81117-3
10342301 17936 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 424 10 2 5 3.7 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL125937 17936 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 424 10 2 5 3.7 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
44277547 99201 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 589 10 0 9 6.2 CCCCCN(C(=O)c1cccs1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL281453 99201 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 589 10 0 9 6.2 CCCCCN(C(=O)c1cccs1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
44277463 101304 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 584 10 0 9 5.5 CCCCCN(C(=O)c1ccncc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL29654 101304 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 584 10 0 9 5.5 CCCCCN(C(=O)c1ccncc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
44348408 113571 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 10.1021/jm00075a033
CHEMBL332239 113571 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 10.1021/jm00075a033
44379086 56576 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 543 9 1 6 5.4 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL164174 56576 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 543 9 1 6 5.4 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
108185 1612 None 78 Rabbit Binding pIC50 = 8.6 8.6 - 1
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00043a020
586 1612 None 78 Rabbit Binding pIC50 = 8.6 8.6 - 1
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00043a020
CHEMBL907 1612 None 78 Rabbit Binding pIC50 = 8.6 8.6 - 1
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00043a020
10372723 107316 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL317368 107316 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00043a020
10349029 208094 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 10.1021/jm00043a020
CHEMBL97812 208094 None 0 Rabbit Binding pIC50 = 8.6 8.6 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 10.1021/jm00043a020
145946921 167598 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 592 11 1 7 5.5 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2337687 167598 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 592 11 1 7 5.5 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2337688 167598 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 592 11 1 7 5.5 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL4300967 167598 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 592 11 1 7 5.5 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
10298977 206321 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 471 9 1 7 4.9 CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL87239 206321 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 471 9 1 7 4.9 CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
131654 206401 None 12 Rabbit Binding pIC50 = 8.5 8.5 - 1
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL87778 206401 None 12 Rabbit Binding pIC50 = 8.5 8.5 - 1
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
10055096 98283 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 656 15 1 7 7.3 CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL274712 98283 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 656 15 1 7 7.3 CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1016/S0960-894X(01)81132-X
25147556 173861 None 0 Bovine Binding pIC50 = 8.5 8.5 - 0
Displacement of radiolabeled angiotensin 2 from angiotensin AT1 receptor in bovine adrenal cortex membranesDisplacement of radiolabeled angiotensin 2 from angiotensin AT1 receptor in bovine adrenal cortex membranes
ChEMBL 538 7 1 6 6.9 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL453934 173861 None 0 Bovine Binding pIC50 = 8.5 8.5 - 0
Displacement of radiolabeled angiotensin 2 from angiotensin AT1 receptor in bovine adrenal cortex membranesDisplacement of radiolabeled angiotensin 2 from angiotensin AT1 receptor in bovine adrenal cortex membranes
ChEMBL 538 7 1 6 6.9 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 10.1016/j.bmc.2010.10.043
44377261 119916 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 402 8 1 7 3.6 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349389 119916 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 402 8 1 7 3.6 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 10.1016/S0960-894X(01)81124-0
10055096 98283 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 656 15 1 7 7.3 CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
CHEMBL274712 98283 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 656 15 1 7 7.3 CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
44316916 205294 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Tested for inhibition of Angiotensin II specific binding to Angiotensin II receptor, type 1 in the recombinant human AT-1 receptor expressed in LhAT-1D6 cellsTested for inhibition of Angiotensin II specific binding to Angiotensin II receptor, type 1 in the recombinant human AT-1 receptor expressed in LhAT-1D6 cells
ChEMBL 474 12 4 5 4.2 CCCCc1ncc(CN[C@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1016/0960-894X(94)00456-P
CHEMBL79242 205294 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Tested for inhibition of Angiotensin II specific binding to Angiotensin II receptor, type 1 in the recombinant human AT-1 receptor expressed in LhAT-1D6 cellsTested for inhibition of Angiotensin II specific binding to Angiotensin II receptor, type 1 in the recombinant human AT-1 receptor expressed in LhAT-1D6 cells
ChEMBL 474 12 4 5 4.2 CCCCc1ncc(CN[C@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1016/0960-894X(94)00456-P
44295009 187169 None 0 Bovine Binding pIC50 = 7.7 7.7 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 473 8 1 6 4.9 CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80474-6
CHEMBL49207 187169 None 0 Bovine Binding pIC50 = 7.7 7.7 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 473 8 1 6 4.9 CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80474-6
44275060 99713 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 576 7 2 7 6.3 O=C(O)c1ccccc1-c1ccc(-c2nc3ccccc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL284764 99713 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 576 7 2 7 6.3 O=C(O)c1ccccc1-c1ccc(-c2nc3ccccc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(00)80335-2
10370172 50826 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 544 12 3 7 5.5 CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL157690 50826 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 544 12 3 7 5.5 CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44277444 100935 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 569 11 0 8 6.5 CCCCCN(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL29402 100935 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 569 11 0 8 6.5 CCCCCN(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
15356436 102012 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 514 12 3 6 4.9 CCCCc1ncc(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
CHEMBL301705 102012 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 514 12 3 6 4.9 CCCCc1ncc(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
44311406 103805 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL309081 103805 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44341670 9954 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 434 9 1 3 6.0 CCCCC1=NC(C(C)C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL114687 9954 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 434 9 1 3 6.0 CCCCC1=NC(C(C)C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
44322315 206256 None 0 Guinea pig Binding pIC50 = 7.7 7.7 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparation
ChEMBL 469 7 1 7 4.7 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)OC)c2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
CHEMBL86858 206256 None 0 Guinea pig Binding pIC50 = 7.7 7.7 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparation
ChEMBL 469 7 1 7 4.7 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)OC)c2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
44285177 138654 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 496 6 1 5 4.9 CCCC1=NC(C(F)(F)F)(C(F)(F)F)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL37768 138654 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 496 6 1 5 4.9 CCCC1=NC(C(F)(F)F)(C(F)(F)F)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
10370172 50826 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 544 12 3 7 5.5 CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL157690 50826 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 544 12 3 7 5.5 CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
73349424 92629 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 495 7 1 4 6.3 CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435833 92629 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 495 7 1 4 6.3 CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
44311568 98182 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 607 13 2 8 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL273992 98182 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 607 13 2 8 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311636 204127 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 549 9 2 9 3.8 CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70389 204127 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 549 9 2 9 3.8 CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311569 204702 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 625 13 2 7 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL74113 204702 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 625 13 2 7 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44377086 119949 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 546 11 2 7 4.8 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349652 119949 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 546 11 2 7 4.8 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
10202093 206433 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 417 8 1 7 3.9 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL87985 206433 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 417 8 1 7 3.9 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
44305267 203399 None 0 Bovine Binding pIC50 = 7.7 7.7 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 536 9 1 9 3.7 CCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL65503 203399 None 0 Bovine Binding pIC50 = 7.7 7.7 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 536 9 1 9 3.7 CCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
19385603 98777 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 455 9 1 5 5.6 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL278234 98777 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 455 9 1 5 5.6 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
1481 2064 None 116 Human Binding pIC50 = 7.7 7.7 1 3
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/j.bmc.2010.10.043
3749 2064 None 116 Human Binding pIC50 = 7.7 7.7 1 3
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/j.bmc.2010.10.043
589 2064 None 116 Human Binding pIC50 = 7.7 7.7 1 3
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/j.bmc.2010.10.043
6908 2064 None 116 Human Binding pIC50 = 7.7 7.7 1 3
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/j.bmc.2010.10.043
CHEMBL1513 2064 None 116 Human Binding pIC50 = 7.7 7.7 1 3
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/j.bmc.2010.10.043
DB01029 2064 None 116 Human Binding pIC50 = 7.7 7.7 1 3
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1016/j.bmc.2010.10.043
44294976 161665 None 0 Bovine Binding pIC50 = 6.7 6.7 - 0
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 431 6 1 6 3.7 CCOC(=O)/C=C1\CC(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80474-6
CHEMBL413098 161665 None 0 Bovine Binding pIC50 = 6.7 6.7 - 0
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 431 6 1 6 3.7 CCOC(=O)/C=C1\CC(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80474-6
15699056 109678 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity against Angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against Angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 396 7 2 6 3.8 CCCCc1nc(CO)c(Cl)n1Cc1ccc2cc(-c3nn[nH]n3)ccc2c1 10.1021/jm00114a021
CHEMBL322683 109678 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity against Angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against Angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 396 7 2 6 3.8 CCCCc1nc(CO)c(Cl)n1Cc1ccc2cc(-c3nn[nH]n3)ccc2c1 10.1021/jm00114a021
44459821 96382 None 0 Rabbit Binding pIC50 = 6.7 6.7 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 412 7 1 4 5.2 CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL26179 96382 None 0 Rabbit Binding pIC50 = 6.7 6.7 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 412 7 1 4 5.2 CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(00)80334-0
11930 1018 None 0 Rabbit Binding pIC50 = 6.7 6.7 - 2
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 10.1016/S0960-894X(01)80517-5
15780052 1018 None 0 Rabbit Binding pIC50 = 6.7 6.7 - 2
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 10.1016/S0960-894X(01)80517-5
CHEMBL289472 1018 None 0 Rabbit Binding pIC50 = 6.7 6.7 - 2
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 10.1016/S0960-894X(01)80517-5
44438869 146333 None 0 Bovine Binding pIC50 = 6.7 6.7 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 413 5 1 8 3.2 COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 10.1016/j.bmcl.2007.02.042
CHEMBL392118 146333 None 0 Bovine Binding pIC50 = 6.7 6.7 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 413 5 1 8 3.2 COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 10.1016/j.bmcl.2007.02.042
10600595 111146 None 23 Bovine Binding pIC50 = 6.7 6.7 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 474 9 2 8 4.1 CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
CHEMBL326400 111146 None 23 Bovine Binding pIC50 = 6.7 6.7 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 474 9 2 8 4.1 CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
44342142 9945 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 407 9 2 5 3.5 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C)C(=O)O 10.1016/S0960-894X(01)81117-3
CHEMBL114653 9945 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 407 9 2 5 3.5 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C)C(=O)O 10.1016/S0960-894X(01)81117-3
10363869 20464 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 404 10 1 7 4.0 CCCCc1nc(CCCC)n(Cc2ccc(-n3ccc(-c4nn[nH]n4)c3)cc2)n1 10.1021/jm00053a013
CHEMBL13071 20464 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 404 10 1 7 4.0 CCCCc1nc(CCCC)n(Cc2ccc(-n3ccc(-c4nn[nH]n4)c3)cc2)n1 10.1021/jm00053a013
54768659 65114 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 507 8 1 8 4.6 CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccccc1 10.1016/j.ejmech.2011.05.056
CHEMBL1823999 65114 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 507 8 1 8 4.6 CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccccc1 10.1016/j.ejmech.2011.05.056
10096495 19375 None 0 Guinea pig Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 475 6 1 5 6.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C(F)(F)F)c2n1 10.1021/jm00100a007
CHEMBL129194 19375 None 0 Guinea pig Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 475 6 1 5 6.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C(F)(F)F)c2n1 10.1021/jm00100a007
15699055 5129 None 0 Rat Binding pIC50 = 4.7 4.7 - 0
Binding affinity against Angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against Angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 396 7 2 6 3.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc2ccc(-c3nn[nH]n3)cc2c1 10.1021/jm00114a021
CHEMBL105724 5129 None 0 Rat Binding pIC50 = 4.7 4.7 - 0
Binding affinity against Angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against Angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 396 7 2 6 3.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc2ccc(-c3nn[nH]n3)cc2c1 10.1021/jm00114a021
10810628 194688 None 0 Bovine Binding pIC50 = 4.7 4.7 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 394 8 3 5 3.4 CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL53322 194688 None 0 Bovine Binding pIC50 = 4.7 4.7 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 394 8 3 5 3.4 CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
44309366 204098 None 0 Bovine Binding pIC50 = 4.7 4.7 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 294 5 1 3 4.4 CCCCc1nc2ccccc2n1Cc1ccc(O)c(C)c1 10.1016/S0960-894X(01)81149-5
CHEMBL70239 204098 None 0 Bovine Binding pIC50 = 4.7 4.7 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 294 5 1 3 4.4 CCCCc1nc2ccccc2n1Cc1ccc(O)c(C)c1 10.1016/S0960-894X(01)81149-5
10810628 194688 None 0 Bovine Binding pIC50 = 4.7 4.7 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 394 8 3 5 3.4 CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
CHEMBL53322 194688 None 0 Bovine Binding pIC50 = 4.7 4.7 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 394 8 3 5 3.4 CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
127035068 136371 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 633 10 2 7 7.7 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735036 136371 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 633 10 2 7 7.7 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
164611280 184997 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4854474 184997 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
53309272 63772 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 449 4 1 6 5.3 CCc1nc2c(C)c(C)c(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
CHEMBL1801736 63772 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 449 4 1 6 5.3 CCc1nc2c(C)c(C)c(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
1315061 28242 None 9 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 409 7 1 4 3.3 Cc1ccc(CN(c2ccc(C(=O)NCc3ccccn3)cc2)S(C)(=O)=O)cc1 10.1016/j.bmc.2016.07.047
CHEMBL1374011 28242 None 9 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 409 7 1 4 3.3 Cc1ccc(CN(c2ccc(C(=O)NCc3ccccn3)cc2)S(C)(=O)=O)cc1 10.1016/j.bmc.2016.07.047
70682147 76335 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 573 10 2 6 6.3 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058866 76335 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 573 10 2 6 6.3 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
10029950 50639 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 530 12 2 7 5.9 CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL157524 50639 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 530 12 2 7 5.9 CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
14956750 206083 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 469 8 1 7 4.4 CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL85596 206083 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 469 8 1 7 4.4 CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44277653 101406 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 645 11 0 9 5.9 CCCCCN(C(=O)c1ccc([S+](C)[O-])cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL29730 101406 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 645 11 0 9 5.9 CCCCCN(C(=O)c1ccc([S+](C)[O-])cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
18004820 16451 None 0 Human Binding pIC50 = 7.7 7.7 - 1
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 527 9 2 7 4.7 CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL12333 16451 None 0 Human Binding pIC50 = 7.7 7.7 - 1
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 527 9 2 7 4.7 CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10029950 50639 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 530 12 2 7 5.9 CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL157524 50639 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 530 12 2 7 5.9 CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
44377198 56519 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 531 10 1 7 4.8 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL163628 56519 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 531 10 1 7 4.8 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
10259334 208036 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 13 1 10 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm00043a020
CHEMBL97500 208036 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 13 1 10 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm00043a020
23590371 161403 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 553 12 1 10 4.2 CCCCc1nn(CC(=O)c2cc(OC)ccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL412664 161403 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 553 12 1 10 4.2 CCCCc1nn(CC(=O)c2cc(OC)ccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
10076199 116653 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 548 9 3 6 6.7 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
CHEMBL337025 116653 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 548 9 3 6 6.7 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
9805344 99038 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 483 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
CHEMBL280290 99038 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 483 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
15287886 137608 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 483 8 1 5 6.3 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2c(Cl)cccc2Cl)cc1 10.1016/0960-894X(94)00476-V
CHEMBL37566 137608 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 483 8 1 5 6.3 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2c(Cl)cccc2Cl)cc1 10.1016/0960-894X(94)00476-V
44286911 161787 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 378 5 1 2 6.2 O=C(O)C(Oc1ccc(Cl)cc1C1CCCCC1)c1ccc(Cl)cc1 10.1016/0960-894X(94)00476-V
CHEMBL41416 161787 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 378 5 1 2 6.2 O=C(O)C(Oc1ccc(Cl)cc1C1CCCCC1)c1ccc(Cl)cc1 10.1016/0960-894X(94)00476-V
44277462 14770 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 665 11 2 10 5.2 CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL1206522 14770 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 665 11 2 10 5.2 CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL281890 14770 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 665 11 2 10 5.2 CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
10077513 17272 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 612 12 0 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(Br)cs2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL125697 17272 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 612 12 0 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(Br)cs2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
44294989 163204 None 0 Bovine Binding pIC50 = 6.7 6.7 - 0
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 459 7 1 6 4.5 CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 10.1016/S0960-894X(00)80474-6
CHEMBL418269 163204 None 0 Bovine Binding pIC50 = 6.7 6.7 - 0
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 459 7 1 6 4.5 CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 10.1016/S0960-894X(00)80474-6
44293466 101138 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 604 14 1 8 6.0 CCCCc1nc(Cl)c(CCC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 10.1021/jm00064a007
CHEMBL295311 101138 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 604 14 1 8 6.0 CCCCc1nc(Cl)c(CCC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 10.1021/jm00064a007
44293962 101386 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 518 12 2 5 5.8 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2)cc1 10.1021/jm00064a007
CHEMBL297202 101386 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 518 12 2 5 5.8 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2)cc1 10.1021/jm00064a007
44293990 187325 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 548 12 2 7 5.4 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 10.1021/jm00064a007
CHEMBL49306 187325 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 548 12 2 7 5.4 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 10.1021/jm00064a007
10073122 119786 None 0 Rabbit Binding pIC50 = 5.7 5.7 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 464 8 2 6 4.8 CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL348149 119786 None 0 Rabbit Binding pIC50 = 5.7 5.7 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 464 8 2 6 4.8 CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44291654 174265 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 462 11 1 3 6.8 CCCCC1=NC(CC(C)C)(CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL45493 174265 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 462 11 1 3 6.8 CCCCC1=NC(CC(C)C)(CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
10073122 119786 None 0 Rabbit Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 464 8 2 6 4.8 CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL348149 119786 None 0 Rabbit Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 464 8 2 6 4.8 CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
44291654 174265 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 462 11 1 3 6.8 CCCCC1=NC(CC(C)C)(CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL45493 174265 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 462 11 1 3 6.8 CCCCC1=NC(CC(C)C)(CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
44296533 194740 None 0 Bovine Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 393 8 3 4 4.0 CCCc1cc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
CHEMBL53631 194740 None 0 Bovine Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 393 8 3 4 4.0 CCCc1cc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
44304147 100774 None 0 Rabbit Binding pIC50 = 4.7 4.7 - 0
Inhibition of Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 522 11 0 4 5.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 10.1016/S0960-894X(01)81007-6
CHEMBL292939 100774 None 0 Rabbit Binding pIC50 = 4.7 4.7 - 0
Inhibition of Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 522 11 0 4 5.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 10.1016/S0960-894X(01)81007-6
46910583 70350 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 561 11 2 5 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945008 70350 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 561 11 2 5 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
127036297 136425 None 0 Human Binding pIC50 = 6.7 6.7 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 547 10 3 5 6.2 CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735492 136425 None 0 Human Binding pIC50 = 6.7 6.7 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 547 10 3 5 6.2 CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
11190917 168805 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 484 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(CC(=O)O)c(Cl)nc3ccccc23)cc1 10.1021/jm031100t
CHEMBL437659 168805 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 484 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(CC(=O)O)c(Cl)nc3ccccc23)cc1 10.1021/jm031100t
127035219 136356 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3734849 136356 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
4803452 39632 None 6 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 457 6 1 4 3.6 Cc1ccc(C)c(NC(=O)CN(C)C(=O)c2ccc(S(=O)(=O)N3CCCCCC3)cc2)c1 10.1016/j.bmc.2016.07.047
CHEMBL1474431 39632 None 6 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 457 6 1 4 3.6 Cc1ccc(C)c(NC(=O)CN(C)C(=O)c2ccc(S(=O)(=O)N3CCCCCC3)cc2)c1 10.1016/j.bmc.2016.07.047
10275744 206116 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 451 8 1 7 4.3 CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL85876 206116 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 451 8 1 7 4.3 CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
15356432 186667 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 576 14 3 6 5.9 CCCCc1nc(Cl)c(CCC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
CHEMBL48824 186667 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 576 14 3 6 5.9 CCCCc1nc(Cl)c(CCC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
44307195 102256 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 452 4 1 6 3.9 CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)81148-3
CHEMBL303186 102256 None 0 Rabbit Binding pIC50 = 7.7 7.7 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 452 4 1 6 3.9 CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)81148-3
44264673 204690 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 402 7 2 6 4.3 CCCCc1nc2cnnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
CHEMBL7396 204690 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 402 7 2 6 4.3 CCCCc1nc2cnnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
44459662 96042 None 0 Bovine Binding pIC50 = 7.7 7.7 - 0
Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortexConcentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortex
ChEMBL 518 8 2 7 5.1 CCCCc1nc2ccc(C3=NNC(=O)CC3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
CHEMBL25989 96042 None 0 Bovine Binding pIC50 = 7.7 7.7 - 0
Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortexConcentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortex
ChEMBL 518 8 2 7 5.1 CCCCc1nc2ccc(C3=NNC(=O)CC3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
108185 1612 None 78 Bovine Binding pIC50 = 7.7 7.7 - 1
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm950450f
586 1612 None 78 Bovine Binding pIC50 = 7.7 7.7 - 1
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm950450f
CHEMBL907 1612 None 78 Bovine Binding pIC50 = 7.7 7.7 - 1
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm950450f
10027836 18947 None 0 Guinea pig Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 437 7 1 6 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 10.1021/jm00100a007
CHEMBL128644 18947 None 0 Guinea pig Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 437 7 1 6 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 10.1021/jm00100a007
44309264 102675 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 555 12 2 10 4.0 CCCCc1nn(CC(O)c2cc(OC)ccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL304600 102675 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 555 12 2 10 4.0 CCCCc1nn(CC(O)c2cc(OC)ccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
10222835 206143 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 403 8 1 7 3.3 CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL86084 206143 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 403 8 1 7 3.3 CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
108185 1612 None 78 Bovine Binding pIC50 = 7.7 7.7 - 1
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1016/S0960-894X(01)81143-4
586 1612 None 78 Bovine Binding pIC50 = 7.7 7.7 - 1
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1016/S0960-894X(01)81143-4
CHEMBL907 1612 None 78 Bovine Binding pIC50 = 7.7 7.7 - 1
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1016/S0960-894X(01)81143-4
CHEMBL5271903 193700 None 0 Human Binding pIC50 = 7.7 7.7 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 321 5 1 3 4.4 CCCCc1c(C(=O)O)c2ccccc2n1C(=O)c1ccccc1 10.1016/j.bmcl.2023.129349
CHEMBL5273768 193774 None 0 Human Binding pIC50 = 7.7 7.7 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 455 7 1 5 5.0 O=C(O)c1c(COCc2ccccc2)n(-c2ccc(S(=O)(=O)Cl)cc2)c2ccccc12 10.1016/j.bmcl.2023.129349
46910494 76331 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 585 11 2 7 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058862 76331 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 585 11 2 7 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
44341489 9298 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 575 12 4 6 2.7 CCCCC1=NC2(CCN(C(=O)C(N)CCCN=C(N)N)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL110974 9298 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 575 12 4 6 2.7 CCCCC1=NC2(CCN(C(=O)C(N)CCCN=C(N)N)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
10096463 48880 None 0 Rabbit Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 474 8 1 7 5.4 CCCCc1nn2c(-c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL155954 48880 None 0 Rabbit Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 474 8 1 7 5.4 CCCCc1nn2c(-c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
10435012 117008 None 0 Guinea pig Binding pIC50 = 6.7 6.7 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 437 7 1 6 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(OC)cc2n1 10.1021/jm00100a007
CHEMBL338900 117008 None 0 Guinea pig Binding pIC50 = 6.7 6.7 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 437 7 1 6 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(OC)cc2n1 10.1021/jm00100a007
44309242 203463 None 0 Bovine Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 339 6 1 5 4.3 CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)81149-5
CHEMBL65955 203463 None 0 Bovine Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 339 6 1 5 4.3 CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)81149-5
44308785 204076 None 0 Bovine Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 420 5 1 3 5.0 CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(I)c1 10.1016/S0960-894X(01)81149-5
CHEMBL70134 204076 None 0 Bovine Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 420 5 1 3 5.0 CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(I)c1 10.1016/S0960-894X(01)81149-5
14956797 206417 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL87885 206417 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
76321525 105245 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 552 9 1 7 7.2 CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmcl.2014.01.004
CHEMBL3115243 105245 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 552 9 1 7 7.2 CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmcl.2014.01.004
44278151 99111 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 619 11 0 9 5.4 CCCCS(=O)(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL280875 99111 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 619 11 0 9 5.4 CCCCS(=O)(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
9824568 204411 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytesCompound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes
ChEMBL 441 5 2 7 2.8 Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/s0960-894x(02)00303-7
CHEMBL72053 204411 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytesCompound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes
ChEMBL 441 5 2 7 2.8 Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/s0960-894x(02)00303-7
127035716 136432 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 545 10 2 4 7.2 CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735588 136432 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 545 10 2 4 7.2 CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
44211673 59718 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 678 4 1 8 6.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
CHEMBL172376 59718 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 678 4 1 8 6.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
14950503 99550 None 0 Guinea pig Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 429 7 1 7 4.2 CCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC 10.1021/jm00061a016
CHEMBL283579 99550 None 0 Guinea pig Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 429 7 1 7 4.2 CCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC 10.1021/jm00061a016
44305410 162357 None 0 Bovine Binding pIC50 = 7.6 7.6 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 556 10 3 8 3.5 CCCc1cc(=O)n(CCNC(=O)NC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL416507 162357 None 0 Bovine Binding pIC50 = 7.6 7.6 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 556 10 3 8 3.5 CCCc1cc(=O)n(CCNC(=O)NC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
73346386 92614 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 531 10 2 4 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL2435818 92614 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 531 10 2 4 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
10460186 116857 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 548 12 0 7 6.0 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2sccc2C)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL338123 116857 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 548 12 0 7 6.0 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2sccc2C)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
70694919 76635 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 386 8 1 6 3.9 CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
CHEMBL2063983 76635 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 386 8 1 6 3.9 CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
130762 98245 None 9 Rabbit Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL274447 98245 None 9 Rabbit Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
44291524 184274 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 462 11 1 3 6.8 CCCCC1=NC(C)(CC(C)CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL48392 184274 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 462 11 1 3 6.8 CCCCC1=NC(C)(CC(C)CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
24827769 95879 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 425 6 1 7 3.7 CC(C)Cn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL259116 95879 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 425 6 1 7 3.7 CC(C)Cn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
54771778 65119 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 479 8 2 8 5.0 CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1Nc1cccc(C)c1 10.1016/j.ejmech.2011.05.056
CHEMBL1824004 65119 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 479 8 2 8 5.0 CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1Nc1cccc(C)c1 10.1016/j.ejmech.2011.05.056
14956757 67591 None 0 Rabbit Binding pIC50 = 4.6 4.6 - 1
Inhibitory activity against Angiotensin II receptor, type 1 bindingInhibitory activity against Angiotensin II receptor, type 1 binding
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm990504b
CHEMBL19018 67591 None 0 Rabbit Binding pIC50 = 4.6 4.6 - 1
Inhibitory activity against Angiotensin II receptor, type 1 bindingInhibitory activity against Angiotensin II receptor, type 1 binding
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm990504b
15287889 100435 None 0 Rabbit Binding pIC50 = 6.6 6.6 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 459 9 2 6 4.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C(=O)O)cc1 10.1016/0960-894X(94)00476-V
CHEMBL290465 100435 None 0 Rabbit Binding pIC50 = 6.6 6.6 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 459 9 2 6 4.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C(=O)O)cc1 10.1016/0960-894X(94)00476-V
19008935 161855 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 463 6 1 6 5.8 CCCCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 10.1021/jm200409s
CHEMBL414836 161855 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 463 6 1 6 5.8 CCCCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 10.1021/jm200409s
19010059 84964 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 568 12 3 9 5.1 CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237598 84964 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 568 12 3 9 5.1 CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
73349223 92188 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 713 14 2 8 7.3 CCCCC(=O)Nc1ccc(C)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-013-0831-x
CHEMBL2425138 92188 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 713 14 2 8 7.3 CCCCC(=O)Nc1ccc(C)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-013-0831-x
44293696 101649 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 568 13 3 7 5.5 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
CHEMBL299130 101649 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 568 13 3 7 5.5 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
44341794 9882 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 418 8 1 3 5.7 CCCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL114267 9882 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 418 8 1 3 5.7 CCCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
53320976 57607 None 0 Guinea pig Binding pIC50 = 7.6 7.6 - 0
Binding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranes
ChEMBL 394 5 1 6 4.8 CCc1cc(Oc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2ncccc2n1 10.1016/j.bmc.2010.10.043
CHEMBL1668124 57607 None 0 Guinea pig Binding pIC50 = 7.6 7.6 - 0
Binding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranes
ChEMBL 394 5 1 6 4.8 CCc1cc(Oc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2ncccc2n1 10.1016/j.bmc.2010.10.043
10280531 162929 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 541 10 2 7 5.1 CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL417429 162929 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 541 10 2 7 5.1 CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
70694919 76635 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 386 8 1 6 3.9 CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
CHEMBL2063983 76635 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 386 8 1 6 3.9 CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
10436877 47993 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 525 11 2 8 5.5 CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL155008 47993 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 525 11 2 8 5.5 CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
9914502 119703 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 515 10 1 7 6.5 CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL347392 119703 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 515 10 1 7 6.5 CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
10327728 98120 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL273542 98120 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44300734 101804 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 586 9 1 7 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL300154 101804 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 586 9 1 7 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
9982171 20503 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 470 8 2 4 5.9 CCCCc1nc2ccc(NC(=O)N(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL130741 20503 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 470 8 2 4 5.9 CCCCc1nc2ccc(NC(=O)N(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
11765394 118775 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 713 14 2 8 7.3 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C 10.1021/jm00052a006
CHEMBL341986 118775 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 713 14 2 8 7.3 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C 10.1021/jm00052a006
44341946 9591 None 13 Human Binding pIC50 = 7.6 7.6 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 407 9 2 5 3.5 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C)C(=O)O 10.1016/S0960-894X(01)81117-3
CHEMBL112523 9591 None 13 Human Binding pIC50 = 7.6 7.6 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 407 9 2 5 3.5 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C)C(=O)O 10.1016/S0960-894X(01)81117-3
CHEMBL5282200 194147 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 345 4 2 5 2.4 Cc1ccc(S(=O)(=O)n2c(CO)c(C(=O)O)c3ccccc32)cc1 10.1016/j.bmcl.2023.129349
71521195 86819 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 508 6 1 8 3.2 CCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322438 86819 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 508 6 1 8 3.2 CCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
44293939 101197 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 590 14 2 7 6.0 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2)cc1 10.1021/jm00064a007
CHEMBL295737 101197 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 590 14 2 7 6.0 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2)cc1 10.1021/jm00064a007
10414026 157509 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 511 7 1 7 6.7 CCCc1nc2ccc(-c3nc4ccccc4o3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
CHEMBL407978 157509 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 511 7 1 7 6.7 CCCc1nc2ccc(-c3nc4ccccc4o3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
44298772 195572 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 452 8 1 7 4.3 CCCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
CHEMBL55507 195572 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 452 8 1 7 4.3 CCCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
44295568 101598 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 465 9 1 6 5.3 CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL298741 101598 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 465 9 1 6 5.3 CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
10255042 116815 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 490 10 1 4 7.3 CCCCc1ncc(/C=C(/C(=O)O)C(c2ccccc2)c2cccs2)n1Cc1ccccc1Cl 10.1021/jm00099a013
CHEMBL337928 116815 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 490 10 1 4 7.3 CCCCc1ncc(/C=C(/C(=O)O)C(c2ccccc2)c2cccs2)n1Cc1ccccc1Cl 10.1021/jm00099a013
44305823 162915 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 400 5 1 7 2.3 Cn1c(=O)cc(C2CC2)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O 10.1016/0960-894X(95)00370-9
CHEMBL417410 162915 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 400 5 1 7 2.3 Cn1c(=O)cc(C2CC2)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O 10.1016/0960-894X(95)00370-9
44295568 101598 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 465 9 1 6 5.3 CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL298741 101598 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 465 9 1 6 5.3 CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
10459724 17974 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 532 12 1 7 4.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]c(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL126170 17974 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 532 12 1 7 4.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]c(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
70688681 76637 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 364 8 2 4 4.1 CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.07.040
CHEMBL2063985 76637 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 364 8 2 4 4.1 CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.07.040
70688681 76637 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 364 8 2 4 4.1 CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.07.040
CHEMBL2063985 76637 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 364 8 2 4 4.1 CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.07.040
44306706 203087 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 654 10 1 6 7.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc1 10.1016/S0960-894X(01)81148-3
CHEMBL63879 203087 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 654 10 1 6 7.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc1 10.1016/S0960-894X(01)81148-3
44379185 57552 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 603 13 2 7 5.6 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL166428 57552 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 603 13 2 7 5.6 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 10.1016/S0960-894X(01)81125-2
14950506 85792 None 0 Guinea pig Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 434 6 1 6 5.2 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccncc2)c(C)n1 10.1021/jm00061a016
CHEMBL22945 85792 None 0 Guinea pig Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 434 6 1 6 5.2 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccncc2)c(C)n1 10.1021/jm00061a016
15171385 166947 None 0 Guinea pig Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 425 6 1 5 5.3 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCCC2 10.1021/jm00061a016
CHEMBL428711 166947 None 0 Guinea pig Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 425 6 1 5 5.3 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCCC2 10.1021/jm00061a016
14951063 102137 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 551 10 1 8 5.1 CCCCc1nn(CC(=O)C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL302478 102137 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 551 10 1 8 5.1 CCCCc1nn(CC(=O)C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
44305400 202944 None 0 Bovine Binding pIC50 = 7.6 7.6 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 478 8 1 7 3.9 CCCc1cc(=O)n(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL62936 202944 None 0 Bovine Binding pIC50 = 7.6 7.6 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 478 8 1 7 3.9 CCCc1cc(=O)n(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
76315849 85409 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 626 13 0 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2csc(Br)c2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL2263542 85409 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 626 13 0 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2csc(Br)c2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL5277518 193934 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 359 6 1 5 2.9 CS(=O)(=O)n1c(COCc2ccccc2)c(C(=O)O)c2ccccc21 10.1016/j.bmcl.2023.129349
9912059 185354 None 0 Bovine Binding pIC50 = 6.6 6.6 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 459 7 1 6 4.5 CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80474-6
CHEMBL48602 185354 None 0 Bovine Binding pIC50 = 6.6 6.6 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 459 7 1 6 4.5 CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80474-6
44306709 102687 None 0 Rabbit Binding pIC50 = 6.6 6.6 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 547 6 1 5 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1cc(Br)c(O)c(Br)c1 10.1016/S0960-894X(01)81148-3
CHEMBL304655 102687 None 0 Rabbit Binding pIC50 = 6.6 6.6 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 547 6 1 5 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1cc(Br)c(O)c(Br)c1 10.1016/S0960-894X(01)81148-3
44341585 9905 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 522 9 3 6 3.6 CCCCC1=NC2(CCN(C(=O)C(N)CS)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL114368 9905 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 522 9 3 6 3.6 CCCCC1=NC2(CCN(C(=O)C(N)CS)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
44298759 189870 None 0 Bovine Binding pIC50 = 6.6 6.6 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 438 7 1 7 3.9 CCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
CHEMBL51689 189870 None 0 Bovine Binding pIC50 = 6.6 6.6 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 438 7 1 7 3.9 CCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
19976317 206387 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 416 10 1 7 4.3 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccncc3-c3nn[nH]n3)cc2)n1 10.1021/jm031100t
CHEMBL87655 206387 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 416 10 1 7 4.3 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccncc3-c3nn[nH]n3)cc2)n1 10.1021/jm031100t
9912059 185354 None 0 Bovine Binding pIC50 = 6.6 6.6 - 1
Binding affinity to angiotensin AT1 receptor in bovine adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in bovine adrenal cortex membranes
ChEMBL 459 7 1 6 4.5 CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL48602 185354 None 0 Bovine Binding pIC50 = 6.6 6.6 - 1
Binding affinity to angiotensin AT1 receptor in bovine adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in bovine adrenal cortex membranes
ChEMBL 459 7 1 6 4.5 CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
44348378 164211 None 0 Bovine Binding pIC50 = 6.6 6.6 - 0
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 457 6 1 6 4.3 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCC2 10.1016/S0960-894X(01)80914-8
CHEMBL421094 164211 None 0 Bovine Binding pIC50 = 6.6 6.6 - 0
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 457 6 1 6 4.3 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCC2 10.1016/S0960-894X(01)80914-8
71521507 86806 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 514 6 1 8 4.6 CCc1nc2ccn(Cc3ccncc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322173 86806 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 514 6 1 8 4.6 CCc1nc2ccn(Cc3ccncc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
19889599 101840 None 0 Bovine Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 494 10 1 7 5.4 CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL300451 101840 None 0 Bovine Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 494 10 1 7 5.4 CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
44438902 169394 None 0 Bovine Binding pIC50 = 6.6 6.6 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 375 5 2 5 3.6 Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL442251 169394 None 0 Bovine Binding pIC50 = 6.6 6.6 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 375 5 2 5 3.6 Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
15654748 203924 None 0 Bovine Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 7 2 7 3.8 COCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL69144 203924 None 0 Bovine Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 7 2 7 3.8 COCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
9912059 185354 None 0 Bovine Binding pIC50 = 6.6 6.6 - 1
Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in bovine adrenal membraneInhibitory activity was evaluated against Angiotensin II receptor, type 1 in bovine adrenal membrane
ChEMBL 459 7 1 6 4.5 CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL48602 185354 None 0 Bovine Binding pIC50 = 6.6 6.6 - 1
Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in bovine adrenal membraneInhibitory activity was evaluated against Angiotensin II receptor, type 1 in bovine adrenal membrane
ChEMBL 459 7 1 6 4.5 CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
19889599 101840 None 0 Bovine Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 494 10 1 7 5.4 CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL300451 101840 None 0 Bovine Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 494 10 1 7 5.4 CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
44294181 187234 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 607 14 2 8 6.2 CCCCc1nc(-n2cccc2)c(C(=O)OCC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
CHEMBL49257 187234 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 607 14 2 8 6.2 CCCCc1nc(-n2cccc2)c(C(=O)OCC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
44341785 10145 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 438 6 1 3 5.3 O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 10.1021/jm00074a018
CHEMBL115771 10145 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 438 6 1 3 5.3 O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 10.1021/jm00074a018
44309021 203976 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 436 5 1 3 5.7 CCCCc1nc2ccccc2n1Cc1cc(Br)c(O)c(Br)c1 10.1016/S0960-894X(01)81149-5
CHEMBL69475 203976 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 436 5 1 3 5.7 CCCCc1nc2ccccc2n1Cc1cc(Br)c(O)c(Br)c1 10.1016/S0960-894X(01)81149-5
44303857 100808 None 0 Rabbit Binding pIC50 = 4.6 4.6 - 0
Inhibition of Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O 10.1016/S0960-894X(01)81007-6
CHEMBL293195 100808 None 0 Rabbit Binding pIC50 = 4.6 4.6 - 0
Inhibition of Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O 10.1016/S0960-894X(01)81007-6
24829094 159070 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 425 8 1 7 4.7 CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 10.1021/jm7011563
CHEMBL409722 159070 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 425 8 1 7 4.7 CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 10.1021/jm7011563
15144943 18045 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 476 9 1 3 6.9 CCCCc1ncc(/C=C(\Cc2ccc(Cl)c(Cl)c2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
CHEMBL126521 18045 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 476 9 1 3 6.9 CCCCc1ncc(/C=C(\Cc2ccc(Cl)c(Cl)c2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
2121575 59539 None 6 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 381 7 1 4 3.5 CN(Cc1cn(-c2ccccc2)nc1-c1ccc(F)cc1)C(=O)CCC(=O)O 10.1016/j.bmc.2016.07.047
CHEMBL1716544 59539 None 6 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 381 7 1 4 3.5 CN(Cc1cn(-c2ccccc2)nc1-c1ccc(F)cc1)C(=O)CCC(=O)O 10.1016/j.bmc.2016.07.047
24828706 158483 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 455 8 1 8 3.9 CCCCn1c(=O)c2ccc(OC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL409095 158483 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 455 8 1 8 3.9 CCCCn1c(=O)c2ccc(OC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
44274707 94362 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 454 7 1 6 4.8 CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL25075 94362 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 454 7 1 6 4.8 CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
10482257 50736 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 534 11 2 6 6.6 CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL157620 50736 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 534 11 2 6 6.6 CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44274707 94362 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 454 7 1 6 4.8 CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL25075 94362 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 454 7 1 6 4.8 CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
1610 2345 None 95 Rat Binding pIC50 = 7.6 7.6 -1 4
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00114a021
3941 2345 None 95 Rat Binding pIC50 = 7.6 7.6 -1 4
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00114a021
3961 2345 None 95 Rat Binding pIC50 = 7.6 7.6 -1 4
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00114a021
590 2345 None 95 Rat Binding pIC50 = 7.6 7.6 -1 4
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00114a021
CHEMBL191 2345 None 95 Rat Binding pIC50 = 7.6 7.6 -1 4
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00114a021
DB00678 2345 None 95 Rat Binding pIC50 = 7.6 7.6 -1 4
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00114a021
11527144 179103 None 0 Bovine Binding pIC50 = 7.6 7.6 - 1
Binding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredBinding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measured
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80366-2
CHEMBL297425 179103 None 0 Bovine Binding pIC50 = 7.6 7.6 - 1
Binding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredBinding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measured
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80366-2
CHEMBL47177 179103 None 0 Bovine Binding pIC50 = 7.6 7.6 - 1
Binding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredBinding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measured
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80366-2
10482257 50736 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 534 11 2 6 6.6 CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL157620 50736 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 534 11 2 6 6.6 CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
10028993 116825 None 0 Guinea pig Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 465 8 1 6 6.0 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC(C)C)ccc2n1 10.1021/jm00100a007
CHEMBL337955 116825 None 0 Guinea pig Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 465 8 1 6 6.0 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC(C)C)ccc2n1 10.1021/jm00100a007
9984807 118455 None 0 Guinea pig Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 505 8 1 6 6.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCC(F)(F)F)ccc2n1 10.1021/jm00100a007
CHEMBL341210 118455 None 0 Guinea pig Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 505 8 1 6 6.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCC(F)(F)F)ccc2n1 10.1021/jm00100a007
131590 20701 None 44 Rat Binding pIC50 = 7.6 7.6 - 3
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL130896 20701 None 44 Rat Binding pIC50 = 7.6 7.6 - 3
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
9984731 21374 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 538 9 2 4 7.3 CCCCc1nc2ccc(N(C)C(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL131433 21374 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 538 9 2 4 7.3 CCCCc1nc2ccc(N(C)C(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
127029203 137425 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 628 12 3 8 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753458 137425 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 628 12 3 8 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
44315057 204827 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL75401 204827 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10076109 112853 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 545 12 0 7 4.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc[n+]2[O-])n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL330942 112853 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 545 12 0 7 4.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc[n+]2[O-])n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
44341453 9682 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 494 8 1 3 7.1 CCCCC1=NC2(CCC(c3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL113039 9682 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 494 8 1 3 7.1 CCCCC1=NC2(CCC(c3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
44342048 110620 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 376 7 1 3 4.5 CCCCC1=NC2(CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL325684 110620 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 376 7 1 3 4.5 CCCCC1=NC2(CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
135987615 100587 None 0 Bovine Binding pIC50 = 6.6 6.6 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 441 6 3 8 4.2 CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
CHEMBL291689 100587 None 0 Bovine Binding pIC50 = 6.6 6.6 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 441 6 3 8 4.2 CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
9933755 55044 None 0 Rabbit Binding pIC50 = 6.6 6.6 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 456 9 1 5 5.3 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL16165 55044 None 0 Rabbit Binding pIC50 = 6.6 6.6 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 456 9 1 5 5.3 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
44293439 101647 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 493 11 2 8 3.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(Cc2ccccc2)n2cnnn2)cc1 10.1021/jm00064a007
CHEMBL299105 101647 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 493 11 2 8 3.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(Cc2ccccc2)n2cnnn2)cc1 10.1021/jm00064a007
15356440 162666 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 450 10 2 5 4.7 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(C#N)Cc2ccccc2)cc1 10.1021/jm00064a007
CHEMBL417009 162666 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 450 10 2 5 4.7 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(C#N)Cc2ccccc2)cc1 10.1021/jm00064a007
19792151 101813 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 9 2 6 4.9 CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL300239 101813 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 9 2 6 4.9 CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
9978845 130710 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 408 9 1 3 5.6 CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
CHEMBL36846 130710 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 408 9 1 3 5.6 CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
11167226 106927 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 466 6 2 6 5.7 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(O)nc3ccccc23)cc1 10.1021/jm031100t
CHEMBL314807 106927 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 466 6 2 6 5.7 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(O)nc3ccccc23)cc1 10.1021/jm031100t
3846 96823 None 4 Rabbit Binding pIC50 = 7.6 7.6 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 452 7 2 7 4.3 CCCCc1nc2ccc(O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL26514 96823 None 4 Rabbit Binding pIC50 = 7.6 7.6 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 452 7 2 7 4.3 CCCCc1nc2ccc(O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/S0960-894X(00)80335-2
14956749 206216 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 479 9 1 7 4.8 CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL86613 206216 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 479 9 1 7 4.8 CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
15356431 101450 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 562 13 3 6 5.5 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
CHEMBL297653 101450 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 562 13 3 6 5.5 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
44341796 163410 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 390 6 1 3 4.9 CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL419583 163410 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 390 6 1 3 4.9 CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
44322239 206719 None 0 Guinea pig Binding pIC50 = 7.6 7.6 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparation
ChEMBL 455 7 2 6 4.6 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)O)c2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
CHEMBL89846 206719 None 0 Guinea pig Binding pIC50 = 7.6 7.6 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparation
ChEMBL 455 7 2 6 4.6 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)O)c2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
11527144 179103 None 0 Bovine Binding pIC50 = 7.6 7.6 - 1
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL297425 179103 None 0 Bovine Binding pIC50 = 7.6 7.6 - 1
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL47177 179103 None 0 Bovine Binding pIC50 = 7.6 7.6 - 1
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
44305681 102625 None 0 Bovine Binding pIC50 = 7.6 7.6 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 550 10 1 9 4.1 CCCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL304251 102625 None 0 Bovine Binding pIC50 = 7.6 7.6 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 550 10 1 9 4.1 CCCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL5289070 194454 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 269 3 2 5 0.6 CS(=O)(=O)n1c(CO)c(C(=O)O)c2ccccc21 10.1016/j.bmcl.2023.129349
9800025 18509 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 380 10 1 5 4.5 CCCCc1nc(CCCC)n(Cc2ccc(-n3cccc3C(=O)O)cc2)n1 10.1021/jm00053a013
CHEMBL12737 18509 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 380 10 1 5 4.5 CCCCc1nc(CCCC)n(Cc2ccc(-n3cccc3C(=O)O)cc2)n1 10.1021/jm00053a013
10739982 10080 None 0 Bovine Binding pIC50 = 6.6 6.6 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 404 8 2 4 5.0 C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)c1C(=O)O 10.1021/jm950450f
CHEMBL115393 10080 None 0 Bovine Binding pIC50 = 6.6 6.6 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 404 8 2 4 5.0 C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)c1C(=O)O 10.1021/jm950450f
10410297 165310 None 0 Guinea pig Binding pIC50 = 6.6 6.6 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 391 5 1 4 5.2 Cc1cc(CCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00100a007
CHEMBL423370 165310 None 0 Guinea pig Binding pIC50 = 6.6 6.6 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 391 5 1 4 5.2 Cc1cc(CCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00100a007
44341923 110323 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 421 10 2 5 4.1 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](CO)C(C)C 10.1016/S0960-894X(01)81117-3
CHEMBL323911 110323 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 421 10 2 5 4.1 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](CO)C(C)C 10.1016/S0960-894X(01)81117-3
10523819 193417 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 380 8 3 5 3.2 CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL52601 193417 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 380 8 3 5 3.2 CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
10523819 193417 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 380 8 3 5 3.2 CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
CHEMBL52601 193417 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 380 8 3 5 3.2 CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
44274741 93255 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 481 8 1 8 4.5 CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL24488 93255 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 481 8 1 8 4.5 CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
76311804 84976 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 507 11 3 8 4.7 CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237610 84976 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 507 11 3 8 4.7 CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
44274741 93255 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 481 8 1 8 4.5 CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL24488 93255 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 481 8 1 8 4.5 CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
127035070 136470 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 647 11 2 7 7.3 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735931 136470 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 647 11 2 7 7.3 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10370801 48427 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 570 12 2 9 4.4 CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL155554 48427 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 570 12 2 9 4.4 CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
10077702 50926 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 464 10 2 7 5.1 CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL157779 50926 None 0 Rabbit Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 464 10 2 7 5.1 CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
70686381 76212 None 0 Bovine Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 486 7 1 6 5.7 CCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058368 76212 None 0 Bovine Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 486 7 1 6 5.7 CCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
10573495 9802 None 0 Bovine Binding pIC50 = 7.6 7.6 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 408 8 3 5 4.0 CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL113714 9802 None 0 Bovine Binding pIC50 = 7.6 7.6 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 408 8 3 5 4.0 CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
10764699 114417 None 0 Bovine Binding pIC50 = 7.6 7.6 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 422 8 3 5 4.2 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL333155 114417 None 0 Bovine Binding pIC50 = 7.6 7.6 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 422 8 3 5 4.2 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
10078475 113328 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331632 113328 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
1610 2345 None 95 Human Binding pIC50 = 7.6 7.6 1 4
Inhibition against human angiotensin II receptor, type 1 (AG2-R)Inhibition against human angiotensin II receptor, type 1 (AG2-R)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0309452
3941 2345 None 95 Human Binding pIC50 = 7.6 7.6 1 4
Inhibition against human angiotensin II receptor, type 1 (AG2-R)Inhibition against human angiotensin II receptor, type 1 (AG2-R)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0309452
3961 2345 None 95 Human Binding pIC50 = 7.6 7.6 1 4
Inhibition against human angiotensin II receptor, type 1 (AG2-R)Inhibition against human angiotensin II receptor, type 1 (AG2-R)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0309452
590 2345 None 95 Human Binding pIC50 = 7.6 7.6 1 4
Inhibition against human angiotensin II receptor, type 1 (AG2-R)Inhibition against human angiotensin II receptor, type 1 (AG2-R)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0309452
CHEMBL191 2345 None 95 Human Binding pIC50 = 7.6 7.6 1 4
Inhibition against human angiotensin II receptor, type 1 (AG2-R)Inhibition against human angiotensin II receptor, type 1 (AG2-R)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0309452
DB00678 2345 None 95 Human Binding pIC50 = 7.6 7.6 1 4
Inhibition against human angiotensin II receptor, type 1 (AG2-R)Inhibition against human angiotensin II receptor, type 1 (AG2-R)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0309452
2541 785 None 120 Rabbit Binding pIC50 = 7.6 7.6 1 6
Inhibitory activity against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm9504722
587 785 None 120 Rabbit Binding pIC50 = 7.6 7.6 1 6
Inhibitory activity against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm9504722
6907 785 None 120 Rabbit Binding pIC50 = 7.6 7.6 1 6
Inhibitory activity against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm9504722
CHEMBL1016 785 None 120 Rabbit Binding pIC50 = 7.6 7.6 1 6
Inhibitory activity against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm9504722
DB00796 785 None 120 Rabbit Binding pIC50 = 7.6 7.6 1 6
Inhibitory activity against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm9504722
DB13919 785 None 120 Rabbit Binding pIC50 = 7.6 7.6 1 6
Inhibitory activity against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm9504722
127034038 139195 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1656 46 15 20 2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3785563 139195 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1656 46 15 20 2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787702 139195 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1656 46 15 20 2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL5275739 193868 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 371 6 1 4 4.2 CCCCc1c(C(=O)O)c2ccccc2n1S(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2023.129349
1610 2345 None 95 Human Binding pIC50 = 7.5 7.5 1 4
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2015.09.010
3941 2345 None 95 Human Binding pIC50 = 7.5 7.5 1 4
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2015.09.010
3961 2345 None 95 Human Binding pIC50 = 7.5 7.5 1 4
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2015.09.010
590 2345 None 95 Human Binding pIC50 = 7.5 7.5 1 4
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2015.09.010
CHEMBL191 2345 None 95 Human Binding pIC50 = 7.5 7.5 1 4
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2015.09.010
DB00678 2345 None 95 Human Binding pIC50 = 7.5 7.5 1 4
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2015.09.010
14951086 169475 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 585 13 1 8 6.2 CCCCc1nn(CC(OCc2ccccc2)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL443005 169475 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 585 13 1 8 6.2 CCCCc1nn(CC(OCc2ccccc2)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
14956803 206283 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 515 9 1 7 5.5 CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL86986 206283 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 515 9 1 7 5.5 CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
15699076 5079 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 390 7 2 4 4.0 CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(C)(C(=O)O)C2 10.1021/jm00114a021
CHEMBL105486 5079 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 390 7 2 4 4.0 CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(C)(C(=O)O)C2 10.1021/jm00114a021
44323112 111641 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 440 8 2 6 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCCC2)cc1 10.1021/jm00092a017
CHEMBL328552 111641 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 440 8 2 6 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCCC2)cc1 10.1021/jm00092a017
19792154 189805 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 1 6 5.3 CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL51634 189805 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 1 6 5.3 CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
19792154 189805 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 1 6 5.3 CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL51634 189805 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 1 6 5.3 CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
19792151 101813 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 9 2 6 4.9 CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL300239 101813 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 9 2 6 4.9 CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
46232959 200924 None 1 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 531 10 2 4 7.3 CCCc1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmcl.2014.01.004
CHEMBL601678 200924 None 1 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 531 10 2 4 7.3 CCCc1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmcl.2014.01.004
44274700 165240 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 470 7 1 6 5.3 CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL422932 165240 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 470 7 1 6 5.3 CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
44274700 165240 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 470 7 1 6 5.3 CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL422932 165240 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 470 7 1 6 5.3 CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
11442998 206189 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 479 6 1 6 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N(C)C)nc3ccccc23)cc1 10.1021/jm031100t
CHEMBL86436 206189 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 479 6 1 6 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N(C)C)nc3ccccc23)cc1 10.1021/jm031100t
15171421 206214 None 0 Guinea pig Binding pIC50 = 7.5 7.5 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 425 6 1 5 5.3 CCc1cc(OCc2ccc(-c3c(C)cccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
CHEMBL86604 206214 None 0 Guinea pig Binding pIC50 = 7.5 7.5 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 425 6 1 5 5.3 CCc1cc(OCc2ccc(-c3c(C)cccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
22407453 49756 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 415 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL15671 49756 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 415 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL5287876 194397 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 295 5 1 4 2.5 CCCCc1c(C(=O)O)c2ccccc2n1S(C)(=O)=O 10.1016/j.bmcl.2023.129349
71521418 86828 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 597 7 1 8 6.1 CCc1nc2ccn(Cc3ccccc3OC(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322447 86828 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 597 7 1 8 6.1 CCc1nc2ccn(Cc3ccccc3OC(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
76333686 85255 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 583 14 1 6 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 10.1007/s00044-009-9205-9
CHEMBL2259777 85255 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 583 14 1 6 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 10.1007/s00044-009-9205-9
9980304 98534 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 433 9 3 8 1.4 CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 10.1021/jm00053a013
CHEMBL276381 98534 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 433 9 3 8 1.4 CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 10.1021/jm00053a013
25147556 173861 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortexDisplacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex
ChEMBL 538 7 1 6 6.9 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 10.1016/j.bmc.2008.10.040
CHEMBL453934 173861 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortexDisplacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex
ChEMBL 538 7 1 6 6.9 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 10.1016/j.bmc.2008.10.040
23590374 203456 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 491 10 1 7 5.0 CCCCc1nn(C/C=C/c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL65905 203456 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 491 10 1 7 5.0 CCCCc1nn(C/C=C/c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
24827900 96863 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 425 6 1 7 3.8 CCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL265452 96863 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 425 6 1 7 3.8 CCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
71623945 136462 None 0 Human Binding pIC50 = 6.5 6.5 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 571 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735839 136462 None 0 Human Binding pIC50 = 6.5 6.5 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 571 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
10052533 116700 None 0 Rat Binding pIC50 = 4.5 4.5 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 524 9 3 4 7.2 CCCCc1nc2c(NC(=O)NC3CCCCC3)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL337269 116700 None 0 Rat Binding pIC50 = 4.5 4.5 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 524 9 3 4 7.2 CCCCc1nc2c(NC(=O)NC3CCCCC3)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
44316861 205183 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Tested for inhibition of Angiotensin II specific binding to Angiotensin II receptor, type 1 in the recombinant human AT-1 receptor expressed in LhAT-1D6 cellsTested for inhibition of Angiotensin II specific binding to Angiotensin II receptor, type 1 in the recombinant human AT-1 receptor expressed in LhAT-1D6 cells
ChEMBL 345 10 3 5 2.1 CCCCc1ncc(CNCC(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1016/0960-894X(94)00456-P
CHEMBL78345 205183 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Tested for inhibition of Angiotensin II specific binding to Angiotensin II receptor, type 1 in the recombinant human AT-1 receptor expressed in LhAT-1D6 cellsTested for inhibition of Angiotensin II specific binding to Angiotensin II receptor, type 1 in the recombinant human AT-1 receptor expressed in LhAT-1D6 cells
ChEMBL 345 10 3 5 2.1 CCCCc1ncc(CNCC(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1016/0960-894X(94)00456-P
44274716 96866 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 514 8 1 8 4.0 CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL26548 96866 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 514 8 1 8 4.0 CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
11756787 119497 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 530 12 2 7 5.9 CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL345459 119497 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 530 12 2 7 5.9 CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
10053110 85258 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 543 12 1 7 5.2 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(N)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL2259780 85258 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 543 12 1 7 5.2 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(N)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
10005890 114454 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 492 9 2 5 4.7 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL333411 114454 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 492 9 2 5 4.7 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
10460419 100331 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 559 10 2 8 5.2 CCCCc1nc2ccn(Cc3ccccc3C(=O)O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
CHEMBL289448 100331 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 559 10 2 8 5.2 CCCCc1nc2ccn(Cc3ccccc3C(=O)O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
10005512 166163 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 483 9 2 8 3.5 CCCCc1nc2ccn(CC(=O)O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
CHEMBL42631 166163 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 483 9 2 8 3.5 CCCCc1nc2ccn(CC(=O)O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
44311775 103012 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306923 103012 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311776 103013 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306924 103013 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311755 103132 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 735 18 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL307866 103132 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 735 18 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311436 204186 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 725 15 1 8 8.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70793 204186 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 725 15 1 8 8.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
10408794 76636 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 402 8 2 6 3.8 CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
CHEMBL2063984 76636 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 402 8 2 6 3.8 CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
44285178 100409 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 386 6 1 5 3.6 CCCC1=NC2(CC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL290180 100409 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 386 6 1 5 3.6 CCCC1=NC2(CC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
11502835 100448 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 428 6 1 5 4.8 CCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL290614 100448 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 428 6 1 5 4.8 CCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
44210864 148103 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 503 8 1 5 4.8 CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL39352 148103 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 503 8 1 5 4.8 CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
11756787 119497 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 530 12 2 7 5.9 CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL345459 119497 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 530 12 2 7 5.9 CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
73346386 92614 None 0 Human Binding pIC50 = 8.5 8.5 - 1
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435818 92614 None 0 Human Binding pIC50 = 8.5 8.5 - 1
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
44311739 102605 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 563 14 2 7 6.2 CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
CHEMBL304137 102605 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 563 14 2 7 6.2 CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
44311498 102928 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 580 10 2 8 4.9 CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306216 102928 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 580 10 2 8 4.9 CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44379182 58120 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 593 10 1 6 6.7 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL167662 58120 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 593 10 1 6 6.7 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
10233073 207631 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 10.1021/jm00043a020
CHEMBL95198 207631 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 10.1021/jm00043a020
2583 3774 None 118 Human Binding pIC50 = 8.5 8.5 - 1
Inhibition of AT1 receptorInhibition of AT1 receptor
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmcl.2009.12.107
592 3774 None 118 Human Binding pIC50 = 8.5 8.5 - 1
Inhibition of AT1 receptorInhibition of AT1 receptor
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmcl.2009.12.107
65999 3774 None 118 Human Binding pIC50 = 8.5 8.5 - 1
Inhibition of AT1 receptorInhibition of AT1 receptor
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmcl.2009.12.107
CHEMBL1017 3774 None 118 Human Binding pIC50 = 8.5 8.5 - 1
Inhibition of AT1 receptorInhibition of AT1 receptor
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmcl.2009.12.107
DB00966 3774 None 118 Human Binding pIC50 = 8.5 8.5 - 1
Inhibition of AT1 receptorInhibition of AT1 receptor
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.bmcl.2009.12.107
2583 3774 None 118 Rat Binding pIC50 = 8.5 8.5 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1021/jm00077a007
592 3774 None 118 Rat Binding pIC50 = 8.5 8.5 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1021/jm00077a007
65999 3774 None 118 Rat Binding pIC50 = 8.5 8.5 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1021/jm00077a007
CHEMBL1017 3774 None 118 Rat Binding pIC50 = 8.5 8.5 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1021/jm00077a007
DB00966 3774 None 118 Rat Binding pIC50 = 8.5 8.5 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1021/jm00077a007
10370090 19705 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 541 8 1 7 5.2 CCCCc1nc2ccc(N3CCCCS3(=O)=O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
CHEMBL130095 19705 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 541 8 1 7 5.2 CCCCc1nc2ccc(N3CCCCS3(=O)=O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
10051708 20718 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 500 7 1 5 7.0 CCCc1nc2ccc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL130910 20718 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 500 7 1 5 7.0 CCCc1nc2ccc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
10052528 165734 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 524 7 1 7 6.5 CCCc1nc2c(C)cc(-c3cn4ccccc4n3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
CHEMBL424629 165734 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 524 7 1 7 6.5 CCCc1nc2c(C)cc(-c3cn4ccccc4n3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
10140613 106094 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 479 10 1 7 4.5 CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL313371 106094 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 479 10 1 7 4.5 CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
14956761 105969 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 494 9 1 8 4.3 CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL313025 105969 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 494 9 1 8 4.3 CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
14956778 206291 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 431 9 1 7 3.9 CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL87057 206291 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 431 9 1 7 3.9 CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44277936 101307 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 573 10 0 9 5.7 CCCCCN(C(=O)c1ccco1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL29658 101307 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 573 10 0 9 5.7 CCCCCN(C(=O)c1ccco1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
9806554 165466 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 515 9 1 7 5.5 CCCCc1nc2ccn(Cc3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
CHEMBL42397 165466 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 515 9 1 7 5.5 CCCCc1nc2ccn(Cc3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
1610 2345 None 95 Human Binding pIC50 = 8.5 8.5 1 4
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.07.047
3941 2345 None 95 Human Binding pIC50 = 8.5 8.5 1 4
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.07.047
3961 2345 None 95 Human Binding pIC50 = 8.5 8.5 1 4
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.07.047
590 2345 None 95 Human Binding pIC50 = 8.5 8.5 1 4
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.07.047
CHEMBL191 2345 None 95 Human Binding pIC50 = 8.5 8.5 1 4
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.07.047
DB00678 2345 None 95 Human Binding pIC50 = 8.5 8.5 1 4
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting methodDisplacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.07.047
10053126 119510 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 544 12 3 7 5.6 CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL345570 119510 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 544 12 3 7 5.6 CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
76330043 85256 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 527 11 2 6 3.8 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 10.1007/s00044-009-9205-9
CHEMBL2259778 85256 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 527 11 2 6 3.8 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 10.1007/s00044-009-9205-9
10007312 113283 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 534 12 0 6 6.0 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CC2CCCCC2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL331519 113283 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 534 12 0 6 6.0 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CC2CCCCC2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
10482937 167135 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL321086 167135 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL429058 167135 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
10053126 119510 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 544 12 3 7 5.6 CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL345570 119510 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 544 12 3 7 5.6 CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
19422633 179620 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 432 8 1 3 5.9 CCCCC1=NC(C)(C2CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL47428 179620 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 432 8 1 3 5.9 CCCCC1=NC(C)(C2CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
44309700 103183 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 651 13 2 7 7.2 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL308237 103183 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 651 13 2 7 7.2 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
10078452 107276 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 10.1021/jm00043a020
CHEMBL317061 107276 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 10.1021/jm00043a020
10482937 167135 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL321086 167135 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL429058 167135 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10439275 168058 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 10.1021/jm00043a020
CHEMBL432392 168058 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 10.1021/jm00043a020
11765177 117006 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338888 117006 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44305634 102373 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 428 8 1 7 3.0 C=CCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O 10.1016/0960-894X(95)00370-9
CHEMBL303822 102373 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 428 8 1 7 3.0 C=CCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O 10.1016/0960-894X(95)00370-9
15231091 93986 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL24861 93986 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
10027175 15536 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 458 9 2 5 4.1 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL121874 15536 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 458 9 2 5 4.1 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
10075811 113281 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 534 12 0 7 5.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL331511 113281 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 534 12 0 7 5.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
44277439 100450 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccncc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL29063 100450 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccncc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
2806 3967 None 110 Rat Binding pIC50 = 8.5 8.5 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm7011563
3937 3967 None 110 Rat Binding pIC50 = 8.5 8.5 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm7011563
593 3967 None 110 Rat Binding pIC50 = 8.5 8.5 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm7011563
60846 3967 None 110 Rat Binding pIC50 = 8.5 8.5 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm7011563
CHEMBL1069 3967 None 110 Rat Binding pIC50 = 8.5 8.5 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm7011563
DB00177 3967 None 110 Rat Binding pIC50 = 8.5 8.5 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm7011563
10417321 15616 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122157 15616 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44305446 100749 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 473 9 2 8 2.0 CCCc1cc(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL292781 100749 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 473 9 2 8 2.0 CCCc1cc(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
15229605 48152 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 463 7 1 5 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 10.1016/0960-894X(95)00185-V
CHEMBL15517 48152 None 0 Rabbit Binding pIC50 = 8.5 8.5 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 463 7 1 5 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 10.1016/0960-894X(95)00185-V
10408794 76636 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 402 8 2 6 3.8 CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
CHEMBL2063984 76636 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 402 8 2 6 3.8 CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
10343090 15532 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 438 10 1 6 3.8 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL121854 15532 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 438 10 1 6 3.8 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
127035246 136394 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 571 10 2 7 6.2 CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735290 136394 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 571 10 2 7 6.2 CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
53309404 63777 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 491 6 1 6 6.4 Cc1cc(CC(C)C)nc2c1nc(C(C)C)n2[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
CHEMBL1801741 63777 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 491 6 1 6 6.4 Cc1cc(CC(C)C)nc2c1nc(C(C)C)n2[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
9853391 116837 None 1 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338027 116837 None 1 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
14956753 107068 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 527 9 1 7 5.9 CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL315776 107068 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 527 9 1 7 5.9 CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
10141821 100056 None 0 Rat Binding pIC50 = 8.4 8.4 - 1
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 501 6 1 7 4.8 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 10.1016/S0960-894X(96)00250-8
CHEMBL287116 100056 None 0 Rat Binding pIC50 = 8.4 8.4 - 1
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 501 6 1 7 4.8 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 10.1016/S0960-894X(96)00250-8
44379270 56855 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 580 9 1 7 5.2 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL164395 56855 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 580 9 1 7 5.2 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
23590373 102635 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 495 10 2 8 4.0 CCCCc1nn(CC(O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL304329 102635 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 495 10 2 8 4.0 CCCCc1nn(CC(O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
10078475 113328 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL331632 113328 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
46910493 76333 None 0 Human Binding pIC50 = 8.4 8.4 - 1
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 615 12 2 8 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058864 76333 None 0 Human Binding pIC50 = 8.4 8.4 - 1
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 615 12 2 8 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
10078475 113328 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331632 113328 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10078475 113328 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL331632 113328 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
4673492 4136 None 9 Guinea pig Binding pIC50 = 8.4 8.4 - 1
Binding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranes
ChEMBL 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 10.1016/j.bmc.2010.10.043
8324 4136 None 9 Guinea pig Binding pIC50 = 8.4 8.4 - 1
Binding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranes
ChEMBL 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 10.1016/j.bmc.2010.10.043
CHEMBL159096 4136 None 9 Guinea pig Binding pIC50 = 8.4 8.4 - 1
Binding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranes
ChEMBL 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 10.1016/j.bmc.2010.10.043
19008869 206412 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 385 5 1 4 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81119-7
CHEMBL87842 206412 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 385 5 1 4 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81119-7
10349791 111577 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 10.1021/jm00043a020
CHEMBL328176 111577 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 10.1021/jm00043a020
44315060 103055 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL307290 103055 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
44338833 9177 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 537 9 2 8 5.4 CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL110265 9177 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 537 9 2 8 5.4 CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
44277593 99409 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 661 9 0 10 5.9 COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 10.1016/0960-894X(95)00224-H
CHEMBL282778 99409 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 661 9 0 10 5.9 COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 10.1016/0960-894X(95)00224-H
127029202 137326 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 598 11 3 7 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752680 137326 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 598 11 3 7 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
73357016 92621 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 503 8 2 4 7.0 CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435825 92621 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 503 8 2 4 7.0 CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
19939495 207823 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL96314 207823 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10461595 208118 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 10.1021/jm00043a020
CHEMBL97964 208118 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 10.1021/jm00043a020
44211677 130612 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 614 4 2 7 6.6 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
CHEMBL368149 130612 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 614 4 2 7 6.6 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
11757471 51055 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 558 12 2 8 5.7 CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL157878 51055 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 558 12 2 8 5.7 CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
10414778 165282 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 534 11 2 6 6.6 CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL423233 165282 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 534 11 2 6 6.6 CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44311609 102806 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL305369 102806 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311638 102923 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 613 18 1 8 6.7 CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306186 102923 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 613 18 1 8 6.7 CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
132562 99681 None 6 Guinea pig Binding pIC50 = 7.5 7.5 - 1
Binding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranes
ChEMBL 407 6 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1016/j.bmc.2010.10.043
CHEMBL284536 99681 None 6 Guinea pig Binding pIC50 = 7.5 7.5 - 1
Binding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranes
ChEMBL 407 6 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1016/j.bmc.2010.10.043
10166561 10062 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 562 9 2 8 5.4 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 10.1039/C4MD00499J
CHEMBL11528 10062 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 562 9 2 8 5.4 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 10.1039/C4MD00499J
10475382 76631 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 388 8 2 6 3.6 CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
CHEMBL2063979 76631 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 388 8 2 6 3.6 CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
11757471 51055 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 558 12 2 8 5.7 CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL157878 51055 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 558 12 2 8 5.7 CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
10100625 51494 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 474 8 1 7 5.4 CCCCc1nn2cc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL158257 51494 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 474 8 1 7 5.4 CCCCc1nn2cc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
10414778 165282 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 534 11 2 6 6.6 CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL423233 165282 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 534 11 2 6 6.6 CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
44275076 93813 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 546 8 1 6 7.0 CCCCc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL24764 93813 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 546 8 1 6 7.0 CCCCc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
10765381 9571 None 0 Bovine Binding pIC50 = 7.5 7.5 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 436 9 3 5 4.6 CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL112414 9571 None 0 Bovine Binding pIC50 = 7.5 7.5 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 436 9 3 5 4.6 CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
1610 2345 None 95 Rabbit Binding pIC50 = 7.5 7.5 -1 4
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
3941 2345 None 95 Rabbit Binding pIC50 = 7.5 7.5 -1 4
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
3961 2345 None 95 Rabbit Binding pIC50 = 7.5 7.5 -1 4
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
590 2345 None 95 Rabbit Binding pIC50 = 7.5 7.5 -1 4
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
CHEMBL191 2345 None 95 Rabbit Binding pIC50 = 7.5 7.5 -1 4
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
DB00678 2345 None 95 Rabbit Binding pIC50 = 7.5 7.5 -1 4
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
9896877 60230 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 748 6 1 8 8.3 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
CHEMBL174080 60230 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 748 6 1 8 8.3 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
14950497 85745 None 0 Guinea pig Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 399 6 1 6 4.3 CC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C 10.1021/jm00061a016
CHEMBL22908 85745 None 0 Guinea pig Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 399 6 1 6 4.3 CC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C 10.1021/jm00061a016
44308901 103113 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 555 13 4 10 3.2 CCCCc1nn(CC(OCC(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2C2=NNNN2)cc1 10.1021/jm00067a015
CHEMBL307752 103113 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 555 13 4 10 3.2 CCCCc1nn(CC(OCC(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2C2=NNNN2)cc1 10.1021/jm00067a015
21840324 10147 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 501 11 2 5 4.9 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(Cc1ccc(F)cc1)C(=O)O 10.1016/S0960-894X(01)81117-3
CHEMBL115783 10147 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 501 11 2 5 4.9 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(Cc1ccc(F)cc1)C(=O)O 10.1016/S0960-894X(01)81117-3
44270306 52175 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 457 8 1 5 6.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 10.1016/0960-894X(95)00185-V
CHEMBL15882 52175 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 457 8 1 5 6.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 10.1016/0960-894X(95)00185-V
10475382 76631 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 388 8 2 6 3.6 CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
CHEMBL2063979 76631 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 388 8 2 6 3.6 CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
57380415 70348 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 577 11 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945006 70348 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 577 11 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
127026336 137272 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 658 13 3 9 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752160 137272 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 658 13 3 9 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
57380416 70349 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 561 11 2 5 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945007 70349 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 561 11 2 5 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
10029332 46891 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 510 12 2 8 4.7 CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL154083 46891 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 510 12 2 8 4.7 CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
130762 98245 None 9 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00064a007
CHEMBL274447 98245 None 9 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00064a007
1610 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81144-6
3941 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81144-6
3961 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81144-6
590 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81144-6
CHEMBL191 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81144-6
DB00678 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81144-6
44285371 140695 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 512 8 1 5 6.0 CCCC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL38161 140695 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 512 8 1 5 6.0 CCCC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
10029332 46891 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 510 12 2 8 4.7 CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL154083 46891 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 510 12 2 8 4.7 CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
10343457 18131 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 444 10 1 5 5.7 CCCCc1ncc(/C=C(\Cc2cc(OC)cs2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
CHEMBL126921 18131 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 444 10 1 5 5.7 CCCCc1ncc(/C=C(\Cc2cc(OC)cs2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
14950495 99291 None 0 Guinea pig Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 357 5 1 5 4.1 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)n1 10.1021/jm00061a016
CHEMBL281999 99291 None 0 Guinea pig Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 357 5 1 5 4.1 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)n1 10.1021/jm00061a016
15654751 203933 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 470 8 2 7 4.9 CCSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL69236 203933 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 470 8 2 7 4.9 CCSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
5284633 10114 None 63 Human Binding pIC50 = 6.5 6.5 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C(=O)O)C(C)C 10.1016/S0960-894X(01)81117-3
CHEMBL115622 10114 None 63 Human Binding pIC50 = 6.5 6.5 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C(=O)O)C(C)C 10.1016/S0960-894X(01)81117-3
19422652 110492 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 502 9 1 3 6.9 CCCCC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL324888 110492 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 502 9 1 3 6.9 CCCCC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
15144944 168030 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 423 9 2 4 5.2 CCCCc1ncc(/C=C(\Cc2ccc(N)cc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
CHEMBL432222 168030 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 423 9 2 4 5.2 CCCCc1ncc(/C=C(\Cc2ccc(N)cc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
11764788 100856 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 1
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL293501 100856 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 1
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10459992 114264 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 542 13 0 6 5.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL333058 114264 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 542 13 0 6 5.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
127034901 136476 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 670 12 2 9 5.5 CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736037 136476 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 670 12 2 9 5.5 CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10029368 119843 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 511 11 1 8 5.8 CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL348606 119843 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 511 11 1 8 5.8 CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
6918269 98468 None 11 Bovine Binding pIC50 = 7.5 7.5 - 2
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL275875 98468 None 11 Bovine Binding pIC50 = 7.5 7.5 - 2
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL295959 98468 None 11 Bovine Binding pIC50 = 7.5 7.5 - 2
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
132562 99681 None 6 Guinea pig Binding pIC50 = 7.5 7.5 - 1
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 407 6 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00100a007
CHEMBL284536 99681 None 6 Guinea pig Binding pIC50 = 7.5 7.5 - 1
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 407 6 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00100a007
132562 99681 None 6 Guinea pig Binding pIC50 = 7.5 7.5 - 1
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 407 6 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00061a016
CHEMBL284536 99681 None 6 Guinea pig Binding pIC50 = 7.5 7.5 - 1
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 407 6 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00061a016
9869504 208045 None 4 Human Binding pIC50 = 7.5 7.5 - 0
Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% BSATested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% BSA
ChEMBL 474 10 2 5 5.9 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 10.1016/S0960-894X(01)81116-1
CHEMBL97533 208045 None 4 Human Binding pIC50 = 7.5 7.5 - 0
Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% BSATested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% BSA
ChEMBL 474 10 2 5 5.9 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 10.1016/S0960-894X(01)81116-1
11764788 100856 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 1
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL293501 100856 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 1
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL5283862 194229 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 295 3 2 4 2.5 O=C(O)c1c(CO)n(C(=O)c2ccccc2)c2ccccc12 10.1016/j.bmcl.2023.129349
76329880 84950 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 448 9 2 8 3.8 CCCCc1nnc(SC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237584 84950 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 448 9 2 8 3.8 CCCCc1nnc(SC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
44323091 206635 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 426 8 2 6 4.2 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCC2)cc1 10.1021/jm00092a017
CHEMBL89216 206635 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 426 8 2 6 4.2 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCC2)cc1 10.1021/jm00092a017
135464357 100556 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 440 6 2 7 4.8 CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
CHEMBL291502 100556 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 440 6 2 7 4.8 CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
10076683 50315 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 405 8 1 7 4.2 CCCCc1nnc(SC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL157203 50315 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 405 8 1 7 4.2 CCCCc1nnc(SC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
9980879 116732 None 0 Guinea pig Binding pIC50 = 6.5 6.5 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 407 5 1 5 5.3 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C)c2n1 10.1021/jm00100a007
CHEMBL337446 116732 None 0 Guinea pig Binding pIC50 = 6.5 6.5 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 407 5 1 5 5.3 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C)c2n1 10.1021/jm00100a007
44294703 192203 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 443 7 1 5 4.9 CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(C)=O)C1 10.1016/S0960-894X(00)80474-6
CHEMBL52046 192203 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 443 7 1 5 4.9 CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(C)=O)C1 10.1016/S0960-894X(00)80474-6
44348345 112842 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 417 6 1 6 3.3 CCOC(=O)/C=C1/C(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80914-8
CHEMBL330866 112842 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 417 6 1 6 3.3 CCOC(=O)/C=C1/C(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80914-8
19889589 185932 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 442 7 1 5 5.9 CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL48692 185932 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 442 7 1 5 5.9 CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
10364310 18888 None 0 Guinea pig Binding pIC50 = 5.5 5.5 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 411 8 1 3 6.5 CCCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 10.1021/jm00100a007
CHEMBL128332 18888 None 0 Guinea pig Binding pIC50 = 5.5 5.5 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 411 8 1 3 6.5 CCCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 10.1021/jm00100a007
19889589 185932 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 442 7 1 5 5.9 CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL48692 185932 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 442 7 1 5 5.9 CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
14962909 101729 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL299597 101729 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
10346400 48908 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 514 11 2 6 6.2 CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL155984 48908 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 514 11 2 6 6.2 CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44306613 203708 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 485 10 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1Oc1ccccc1C(=O)O 10.1016/S0960-894X(01)81148-3
CHEMBL67616 203708 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 485 10 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1Oc1ccccc1C(=O)O 10.1016/S0960-894X(01)81148-3
3839 3755 None 84 Human Binding pIC50 = 7.5 7.5 - 0
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
ChEMBL 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 10.1021/jm0204237
60919 3755 None 84 Human Binding pIC50 = 7.5 7.5 - 0
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
ChEMBL 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 10.1021/jm0204237
6898 3755 None 84 Human Binding pIC50 = 7.5 7.5 - 0
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
ChEMBL 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 10.1021/jm0204237
CHEMBL432162 3755 None 84 Human Binding pIC50 = 7.5 7.5 - 0
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
ChEMBL 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 10.1021/jm0204237
DB01349 3755 None 84 Human Binding pIC50 = 7.5 7.5 - 0
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
ChEMBL 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 10.1021/jm0204237
10346400 48908 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 514 11 2 6 6.2 CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL155984 48908 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 514 11 2 6 6.2 CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
44438865 93373 None 0 Bovine Binding pIC50 = 7.5 7.5 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 441 7 1 8 3.8 CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL245644 93373 None 0 Bovine Binding pIC50 = 7.5 7.5 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 441 7 1 8 3.8 CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
44297201 101990 None 0 Bovine Binding pIC50 = 7.5 7.5 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 617 8 1 9 6.2 CCCCc1nc2ccc([C@@H]3C[C@H]4C5CCC(C)(C)N5O[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL301547 101990 None 0 Bovine Binding pIC50 = 7.5 7.5 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 617 8 1 9 6.2 CCCCc1nc2ccc([C@@H]3C[C@H]4C5CCC(C)(C)N5O[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
44376747 120087 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 510 11 2 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL350851 120087 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 510 11 2 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
15654755 103806 None 0 Bovine Binding pIC50 = 7.5 7.5 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 426 6 2 7 3.6 COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL309084 103806 None 0 Bovine Binding pIC50 = 7.5 7.5 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 426 6 2 7 3.6 COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL5276125 193882 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
ChEMBL 385 6 1 4 4.7 O=C(O)c1c(COCc2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 10.1016/j.bmcl.2023.129349
127029201 137256 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 644 12 3 9 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3751994 137256 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 644 12 3 9 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
44294649 189087 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 445 6 1 6 4.1 CCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 10.1016/S0960-894X(00)80474-6
CHEMBL51001 189087 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 445 6 1 6 4.1 CCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 10.1016/S0960-894X(00)80474-6
11755164 119716 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 486 10 2 6 5.4 CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL347513 119716 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 486 10 2 6 5.4 CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
11756222 49366 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 514 12 2 6 6.0 CCCSc1nnc(CCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL156396 49366 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 514 12 2 6 6.0 CCCSc1nnc(CCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
14962909 101729 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL299597 101729 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
10525501 101807 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 408 8 3 5 3.6 CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL300186 101807 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 408 8 3 5 3.6 CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
10525501 101807 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 408 8 3 5 3.6 CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
CHEMBL300186 101807 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 408 8 3 5 3.6 CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
15745369 10156 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 460 7 0 4 6.6 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1 10.1021/jm00074a018
CHEMBL115835 10156 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 460 7 0 4 6.6 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1 10.1021/jm00074a018
44322953 106549 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 426 8 2 6 4.4 CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCC2)cc1 10.1021/jm00092a017
CHEMBL314149 106549 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 426 8 2 6 4.4 CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCC2)cc1 10.1021/jm00092a017
44308996 102971 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 348 5 1 3 5.4 CCCCc1nc2ccccc2n1Cc1cc(Cl)c(O)c(Cl)c1 10.1016/S0960-894X(01)81149-5
CHEMBL306486 102971 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 348 5 1 3 5.4 CCCCc1nc2ccccc2n1Cc1cc(Cl)c(O)c(Cl)c1 10.1016/S0960-894X(01)81149-5
15654746 203711 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 452 7 2 6 4.8 CC(C)Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL67636 203711 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 452 7 2 6 4.8 CC(C)Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
15287888 100237 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 421 8 1 5 5.2 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)C2CCCCC2)cc1 10.1016/0960-894X(94)00476-V
CHEMBL288618 100237 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 421 8 1 5 5.2 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)C2CCCCC2)cc1 10.1016/0960-894X(94)00476-V
44294207 101551 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 440 9 3 6 4.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)/C(=N\O)c2ccccc2)cc1 10.1021/jm00064a007
CHEMBL298364 101551 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 440 9 3 6 4.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)/C(=N\O)c2ccccc2)cc1 10.1021/jm00064a007
44320536 206391 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 468 5 1 5 4.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2=C3C=CC=CC3N(C)C(=O)C2C(=O)O)cc1 10.1021/jm031100t
CHEMBL87694 206391 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 468 5 1 5 4.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2=C3C=CC=CC3N(C)C(=O)C2C(=O)O)cc1 10.1021/jm031100t
57380413 70527 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947130 70527 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
15355268 101680 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 2 6 5.3 CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL299340 101680 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 2 6 5.3 CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
44274746 99668 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 591 7 3 8 5.9 Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(00)80335-2
CHEMBL284455 99668 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 591 7 3 8 5.9 Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(00)80335-2
10408951 18843 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 404 10 1 7 4.0 CCCCc1nc(CCCC)n(Cc2ccc(-n3cccc3-c3nn[nH]n3)cc2)n1 10.1021/jm00053a013
CHEMBL12810 18843 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 404 10 1 7 4.0 CCCCc1nc(CCCC)n(Cc2ccc(-n3cccc3-c3nn[nH]n3)cc2)n1 10.1021/jm00053a013
14956751 206299 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 509 9 1 9 4.1 CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL87073 206299 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 509 9 1 9 4.1 CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
9824290 194908 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 435 5 1 4 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)ccc3ccccc23)cc1 10.1021/jm031100t
CHEMBL541212 194908 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 435 5 1 4 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)ccc3ccccc23)cc1 10.1021/jm031100t
10483230 46828 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 574 11 2 8 5.1 CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL154027 46828 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 574 11 2 8 5.1 CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
44438885 90952 None 0 Bovine Binding pIC50 = 7.5 7.5 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 417 8 2 5 4.6 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL239378 90952 None 0 Bovine Binding pIC50 = 7.5 7.5 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 417 8 2 5 4.6 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
44315060 103055 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL307290 103055 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
10414301 22198 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 519 11 1 5 6.0 CCCCc1nc2ccc(N(C)S(=O)(=O)CCC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL132280 22198 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 519 11 1 5 6.0 CCCCc1nc2ccc(N(C)S(=O)(=O)CCC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
44295069 101142 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 501 10 1 6 5.7 CCCC1(CCC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(00)80474-6
CHEMBL295369 101142 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 501 10 1 6 5.7 CCCC1(CCC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(00)80474-6
10028212 48916 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 482 11 2 8 3.9 CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL155992 48916 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 482 11 2 8 3.9 CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44293816 185611 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 563 11 1 7 6.5 CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 10.1021/jm00064a007
CHEMBL48640 185611 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 563 11 1 7 6.5 CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 10.1021/jm00064a007
44307174 100741 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 366 6 1 6 4.0 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc([N+](=O)[O-])c1O 10.1016/S0960-894X(01)81148-3
CHEMBL292739 100741 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 366 6 1 6 4.0 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc([N+](=O)[O-])c1O 10.1016/S0960-894X(01)81148-3
1610 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
Binding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredBinding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measured
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80366-2
3941 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
Binding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredBinding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measured
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80366-2
3961 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
Binding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredBinding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measured
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80366-2
590 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
Binding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredBinding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measured
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80366-2
CHEMBL191 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
Binding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredBinding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measured
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80366-2
DB00678 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
Binding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredBinding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measured
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80366-2
10028212 48916 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 482 11 2 8 3.9 CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL155992 48916 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 482 11 2 8 3.9 CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
19792124 188257 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 422 7 1 5 5.6 CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL49980 188257 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 422 7 1 5 5.6 CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
1610 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80377-2
3941 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80377-2
3961 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80377-2
590 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80377-2
CHEMBL191 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80377-2
DB00678 2345 None 95 Bovine Binding pIC50 = 6.5 6.5 - 4
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80377-2
10341766 117075 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 414 9 1 4 5.7 CCCCc1ncc(/C=C(\Cc2ccsc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
CHEMBL339233 117075 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 414 9 1 4 5.7 CCCCc1ncc(/C=C(\Cc2ccsc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
19792124 188257 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 422 7 1 5 5.6 CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL49980 188257 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 422 7 1 5 5.6 CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
44341650 169885 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 406 7 2 3 4.8 CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL444060 169885 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 406 7 2 3 4.8 CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
44352233 18933 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 383 6 1 6 4.0 CCCc1cn2nccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81118-5
CHEMBL128590 18933 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 383 6 1 6 4.0 CCCc1cn2nccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81118-5
44308795 203909 None 0 Bovine Binding pIC50 = 4.5 4.5 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 532 5 1 3 5.3 CCCCc1nc2ccccc2n1Cc1ccc(I)c(O)c1I 10.1016/S0960-894X(01)81149-5
CHEMBL69025 203909 None 0 Bovine Binding pIC50 = 4.5 4.5 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 532 5 1 3 5.3 CCCCc1nc2ccccc2n1Cc1ccc(I)c(O)c1I 10.1016/S0960-894X(01)81149-5
71652856 89142 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 545 11 2 3 6.9 CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2337684 89142 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 545 11 2 3 6.9 CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2365829 89142 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 545 11 2 3 6.9 CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.12.044
44210830 57481 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Binding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assayBinding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assay
ChEMBL 461 6 1 6 5.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 10.1016/S0960-894X(01)80193-1
CHEMBL165850 57481 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Binding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assayBinding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assay
ChEMBL 461 6 1 6 5.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 10.1016/S0960-894X(01)80193-1
14950496 85016 None 0 Guinea pig Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 483 5 1 5 4.7 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(C)n1 10.1021/jm00061a016
CHEMBL22391 85016 None 0 Guinea pig Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 483 5 1 5 4.7 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(C)n1 10.1021/jm00061a016
10436618 21680 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 517 8 1 5 5.7 CCCCc1nc2ccc(N3CCCCS3(=O)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL131839 21680 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 517 8 1 5 5.7 CCCCc1nc2ccc(N3CCCCS3(=O)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
44305634 102373 None 0 Bovine Binding pIC50 = 7.5 7.5 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 428 8 1 7 3.0 C=CCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O 10.1016/0960-894X(95)00370-9
CHEMBL303822 102373 None 0 Bovine Binding pIC50 = 7.5 7.5 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 428 8 1 7 3.0 C=CCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O 10.1016/0960-894X(95)00370-9
11757112 112967 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 542 12 0 6 6.0 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL331081 112967 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 542 12 0 6 6.0 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
44293818 101847 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 579 13 3 7 5.7 CCCCc1nc(-n2cccc2)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
CHEMBL300487 101847 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 579 13 3 7 5.7 CCCCc1nc(-n2cccc2)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
15355268 101680 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 2 6 5.3 CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL299340 101680 None 0 Bovine Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 2 6 5.3 CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
14962904 193099 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 10.1007/s00044-009-9182-z
CHEMBL52265 193099 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 10.1007/s00044-009-9182-z
14962904 193099 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 10.1007/s00044-009-9182-z
CHEMBL52265 193099 None 0 Bovine Binding pIC50 = 5.5 5.5 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 10.1007/s00044-009-9182-z
127034919 136513 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 599 10 2 7 6.6 CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736310 136513 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 599 10 2 7 6.6 CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
127034739 136370 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 585 10 2 6 7.3 CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3734989 136370 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 585 10 2 6 7.3 CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
127026058 137244 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 600 10 3 8 6.0 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3751899 137244 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 600 10 3 8 6.0 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
71521298 86821 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 481 6 2 8 3.2 CCc1nc2ccn(CC(=O)O)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322440 86821 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 481 6 2 8 3.2 CCc1nc2ccn(CC(=O)O)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
76329882 84955 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 538 12 2 8 5.4 CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237589 84955 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 538 12 2 8 5.4 CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
19422640 100489 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 378 7 1 3 4.8 CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL290988 100489 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 378 7 1 3 4.8 CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
44377171 120209 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Binding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assayBinding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assay
ChEMBL 485 6 1 8 5.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 10.1016/S0960-894X(01)80193-1
CHEMBL352042 120209 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Binding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assayBinding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assay
ChEMBL 485 6 1 8 5.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 10.1016/S0960-894X(01)80193-1
10323527 48024 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 495 11 1 7 5.9 CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL155035 48024 None 0 Rabbit Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 495 11 1 7 5.9 CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
19422640 100489 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 378 7 1 3 4.8 CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL290988 100489 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 378 7 1 3 4.8 CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
14951061 204344 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 501 11 1 7 5.7 CCCCc1nn(CCC(C)CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL71613 204344 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 501 11 1 7 5.7 CCCCc1nn(CCC(C)CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
1610 2345 None 95 Rat Binding pIC50 = 7.5 7.5 -1 4
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00077a007
3941 2345 None 95 Rat Binding pIC50 = 7.5 7.5 -1 4
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00077a007
3961 2345 None 95 Rat Binding pIC50 = 7.5 7.5 -1 4
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00077a007
590 2345 None 95 Rat Binding pIC50 = 7.5 7.5 -1 4
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00077a007
CHEMBL191 2345 None 95 Rat Binding pIC50 = 7.5 7.5 -1 4
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00077a007
DB00678 2345 None 95 Rat Binding pIC50 = 7.5 7.5 -1 4
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00077a007
14952925 196820 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 492 10 2 5 6.1 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1cc(Cl)c(C(=O)O)cc1Cl 10.1016/S0960-894X(01)81116-1
CHEMBL56574 196820 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 492 10 2 5 6.1 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1cc(Cl)c(C(=O)O)cc1Cl 10.1016/S0960-894X(01)81116-1
10098291 15556 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 523 10 1 9 3.6 CCCCc1ncc(/C=C2/C(=O)N(CO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL121990 15556 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 523 10 1 9 3.6 CCCCc1ncc(/C=C2/C(=O)N(CO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
76322687 84948 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 535 10 2 8 4.4 CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237582 84948 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 535 10 2 8 4.4 CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
44342045 110374 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 488 7 1 3 7.6 CCCCC1=NC2(CCCCCCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL324245 110374 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 488 7 1 3 7.6 CCCCC1=NC2(CCCCCCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
10323388 49306 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 492 9 1 7 4.8 CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL156352 49306 None 0 Rabbit Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 492 9 1 7 4.8 CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
1610 2345 None 95 Human Binding pIC50 = 6.5 6.5 1 4
Inhibition of ATR1 (unknown origin)Inhibition of ATR1 (unknown origin)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.9b00179
3941 2345 None 95 Human Binding pIC50 = 6.5 6.5 1 4
Inhibition of ATR1 (unknown origin)Inhibition of ATR1 (unknown origin)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.9b00179
3961 2345 None 95 Human Binding pIC50 = 6.5 6.5 1 4
Inhibition of ATR1 (unknown origin)Inhibition of ATR1 (unknown origin)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.9b00179
590 2345 None 95 Human Binding pIC50 = 6.5 6.5 1 4
Inhibition of ATR1 (unknown origin)Inhibition of ATR1 (unknown origin)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.9b00179
CHEMBL191 2345 None 95 Human Binding pIC50 = 6.5 6.5 1 4
Inhibition of ATR1 (unknown origin)Inhibition of ATR1 (unknown origin)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.9b00179
DB00678 2345 None 95 Human Binding pIC50 = 6.5 6.5 1 4
Inhibition of ATR1 (unknown origin)Inhibition of ATR1 (unknown origin)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.9b00179
130762 98245 None 9 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL274447 98245 None 9 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
44323113 206665 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 412 8 2 6 4.0 CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCC2)cc1 10.1021/jm00092a017
CHEMBL89403 206665 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 412 8 2 6 4.0 CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCC2)cc1 10.1021/jm00092a017
76322688 84952 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 530 11 2 8 5.8 CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237586 84952 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 530 11 2 8 5.8 CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
19010047 84967 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 554 12 3 9 4.9 CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237601 84967 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 554 12 3 9 4.9 CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
15224461 19423 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 467 8 2 7 4.7 CCCCc1nc2c(C)cnc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81118-5
CHEMBL129447 19423 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 467 8 2 7 4.7 CCCCc1nc2c(C)cnc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81118-5
9986992 51504 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 511 11 2 8 5.3 CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL158267 51504 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 511 11 2 8 5.3 CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
10032191 119572 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 487 10 1 7 6.2 CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL346145 119572 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 487 10 1 7 6.2 CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
1610 2345 None 95 Rat Binding pIC50 = 7.4 7.4 -1 4
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00067a015
3941 2345 None 95 Rat Binding pIC50 = 7.4 7.4 -1 4
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00067a015
3961 2345 None 95 Rat Binding pIC50 = 7.4 7.4 -1 4
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00067a015
590 2345 None 95 Rat Binding pIC50 = 7.4 7.4 -1 4
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00067a015
CHEMBL191 2345 None 95 Rat Binding pIC50 = 7.4 7.4 -1 4
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00067a015
DB00678 2345 None 95 Rat Binding pIC50 = 7.4 7.4 -1 4
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00067a015
14951090 103208 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 579 13 1 10 4.7 CCCCc1nn(C(CC(=O)OCC)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL308416 103208 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 579 13 1 10 4.7 CCCCc1nn(C(CC(=O)OCC)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
44287123 100189 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 465 8 1 5 6.1 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc3ccccc23)cc1 10.1016/0960-894X(94)00476-V
CHEMBL288222 100189 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 465 8 1 5 6.1 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc3ccccc23)cc1 10.1016/0960-894X(94)00476-V
127029204 137311 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 628 12 3 8 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752530 137311 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 628 12 3 8 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
71521503 86830 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 527 6 1 7 5.5 CCc1nc2ccn(Cc3cccc(C)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322449 86830 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 527 6 1 7 5.5 CCc1nc2ccn(Cc3cccc(C)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
135723833 198509 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 442 6 2 8 4.2 COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
CHEMBL57783 198509 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 442 6 2 8 4.2 COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
10811315 110274 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 406 8 2 4 5.1 CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL323819 110274 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 406 8 2 4 5.1 CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
10412363 20873 None 0 Guinea pig Binding pIC50 = 6.4 6.4 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 432 6 1 6 5.1 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C#N)ccc2n1 10.1021/jm00100a007
CHEMBL131050 20873 None 0 Guinea pig Binding pIC50 = 6.4 6.4 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 432 6 1 6 5.1 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C#N)ccc2n1 10.1021/jm00100a007
121879 2232 None 24 Human Binding pIC50 = 5.4 5.4 - 1
Inhibition against human angiotensin II receptor, type 1 (AG2-R)Inhibition against human angiotensin II receptor, type 1 (AG2-R)
ChEMBL 509 7 3 6 3.6 O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2 10.1021/jm0309452
5868 2232 None 24 Human Binding pIC50 = 5.4 5.4 - 1
Inhibition against human angiotensin II receptor, type 1 (AG2-R)Inhibition against human angiotensin II receptor, type 1 (AG2-R)
ChEMBL 509 7 3 6 3.6 O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2 10.1021/jm0309452
CHEMBL308716 2232 None 24 Human Binding pIC50 = 5.4 5.4 - 1
Inhibition against human angiotensin II receptor, type 1 (AG2-R)Inhibition against human angiotensin II receptor, type 1 (AG2-R)
ChEMBL 509 7 3 6 3.6 O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2 10.1021/jm0309452
1610 2345 None 95 Rat Binding pIC50 = 4.4 4.4 -1 4
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00053a013
3941 2345 None 95 Rat Binding pIC50 = 4.4 4.4 -1 4
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00053a013
3961 2345 None 95 Rat Binding pIC50 = 4.4 4.4 -1 4
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00053a013
590 2345 None 95 Rat Binding pIC50 = 4.4 4.4 -1 4
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00053a013
CHEMBL191 2345 None 95 Rat Binding pIC50 = 4.4 4.4 -1 4
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00053a013
DB00678 2345 None 95 Rat Binding pIC50 = 4.4 4.4 -1 4
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00053a013
127028617 137566 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 536 10 3 7 4.9 CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 10.1039/C5MD00169B
CHEMBL3754661 137566 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 536 10 3 7 4.9 CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 10.1039/C5MD00169B
127034740 136489 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 585 10 2 6 7.3 CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3736166 136489 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 585 10 2 6 7.3 CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
127035544 136358 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 721 14 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3734870 136358 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 721 14 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
19029576 99971 None 0 Rat Binding pIC50 = 7.4 7.4 - 1
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 467 6 1 7 4.1 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2)s1 10.1016/S0960-894X(96)00250-8
CHEMBL286537 99971 None 0 Rat Binding pIC50 = 7.4 7.4 - 1
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 467 6 1 7 4.1 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2)s1 10.1016/S0960-894X(96)00250-8
10692816 9930 None 1 Bovine Binding pIC50 = 7.4 7.4 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 408 7 3 5 3.8 CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL114527 9930 None 1 Bovine Binding pIC50 = 7.4 7.4 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 408 7 3 5 3.8 CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
70688504 76334 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 573 10 2 6 6.3 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058865 76334 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 573 10 2 6 6.3 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
71521301 86824 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 531 6 1 7 5.3 CCc1nc2ccn(Cc3ccccc3F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322443 86824 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 531 6 1 7 5.3 CCc1nc2ccn(Cc3ccccc3F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
76308180 84974 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 508 11 2 8 4.7 CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237608 84974 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 508 11 2 8 4.7 CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
44459780 92160 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 426 7 1 4 5.5 CCCCc1nc2cc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL24218 92160 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 426 7 1 4 5.5 CCCCc1nc2cc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(00)80334-0
44459634 96138 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 426 7 1 4 5.5 CCCCc1nc2cccc(C)c2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL26048 96138 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 426 7 1 4 5.5 CCCCc1nc2cccc(C)c2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(00)80334-0
44294023 184576 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 546 12 2 5 6.4 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2c(C)ccc2C)cc1 10.1021/jm00064a007
CHEMBL48486 184576 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 546 12 2 5 6.4 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2c(C)ccc2C)cc1 10.1021/jm00064a007
10069271 34476 None 0 Guinea pig Binding pIC50 = 6.4 6.4 - 0
Binding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranes
ChEMBL 395 4 1 5 5.5 Cc1cc(Sc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1016/j.bmc.2010.10.043
CHEMBL142860 34476 None 0 Guinea pig Binding pIC50 = 6.4 6.4 - 0
Binding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranes
ChEMBL 395 4 1 5 5.5 Cc1cc(Sc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1016/j.bmc.2010.10.043
10389770 119641 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 465 10 1 7 5.1 CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL346773 119641 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 465 10 1 7 5.1 CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
10252966 32819 None 0 Guinea pig Binding pIC50 = 6.4 6.4 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 409 5 1 5 5.7 Cc1cc(SCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00100a007
CHEMBL141447 32819 None 0 Guinea pig Binding pIC50 = 6.4 6.4 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 409 5 1 5 5.7 Cc1cc(SCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00100a007
127034918 136456 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 599 11 2 7 6.6 CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 10.1039/C4MD00499J
CHEMBL3735797 136456 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 599 11 2 7 6.6 CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 10.1039/C4MD00499J
11527144 179103 None 0 Bovine Binding pIC50 = 7.4 7.4 - 1
Binding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredBinding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measured
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80366-2
CHEMBL297425 179103 None 0 Bovine Binding pIC50 = 7.4 7.4 - 1
Binding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredBinding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measured
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80366-2
CHEMBL47177 179103 None 0 Bovine Binding pIC50 = 7.4 7.4 - 1
Binding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredBinding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measured
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80366-2
44342047 9792 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 390 7 1 3 4.9 CCCCC1=NC2(CCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL113674 9792 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 390 7 1 3 4.9 CCCCC1=NC2(CCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
3839 3755 None 84 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytesCompound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes
ChEMBL 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 10.1016/s0960-894x(02)00303-7
60919 3755 None 84 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytesCompound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes
ChEMBL 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 10.1016/s0960-894x(02)00303-7
6898 3755 None 84 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytesCompound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes
ChEMBL 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 10.1016/s0960-894x(02)00303-7
CHEMBL432162 3755 None 84 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytesCompound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes
ChEMBL 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 10.1016/s0960-894x(02)00303-7
DB01349 3755 None 84 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytesCompound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes
ChEMBL 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 10.1016/s0960-894x(02)00303-7
9830481 194676 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 617 8 1 9 5.9 CCCCc1nc2ccc([C@H]3OC[C@@H]4ON5[C@@H](CCC5(C)C)[C@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL53244 194676 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 617 8 1 9 5.9 CCCCc1nc2ccc([C@H]3OC[C@@H]4ON5[C@@H](CCC5(C)C)[C@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
15287892 100356 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 445 9 1 6 5.0 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OC)cc1 10.1016/0960-894X(94)00476-V
CHEMBL289640 100356 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 445 9 1 6 5.0 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OC)cc1 10.1016/0960-894X(94)00476-V
127035515 136453 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 585 11 2 7 6.3 CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735769 136453 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 585 11 2 7 6.3 CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
44459856 96521 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 462 7 1 4 6.3 CCCCc1nc2cc3ccccc3cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL26277 96521 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 462 7 1 4 6.3 CCCCc1nc2cc3ccccc3cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(00)80334-0
11755164 119716 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 486 10 2 6 5.4 CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL347513 119716 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 486 10 2 6 5.4 CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
127037497 136499 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 613 9 2 7 6.9 CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736225 136499 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 613 9 2 7 6.9 CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
73357018 92630 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 8 2 4 7.3 CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435834 92630 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 8 2 4 7.3 CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
24828707 95935 None 0 Rat Binding pIC50 = 7.4 7.4 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 425 7 1 7 3.9 CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL259353 95935 None 0 Rat Binding pIC50 = 7.4 7.4 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 425 7 1 7 3.9 CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
44377111 119882 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 495 10 1 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349020 119882 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 495 10 1 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
8374 2920 None 42 Human Binding pIC50 = 7.4 7.4 - 1
Inhibition of human AT1 receptorInhibition of human AT1 receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/acs.jmedchem.9b01780
9937291 2920 None 42 Human Binding pIC50 = 7.4 7.4 - 1
Inhibition of human AT1 receptorInhibition of human AT1 receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/acs.jmedchem.9b01780
CHEMBL34124 2920 None 42 Human Binding pIC50 = 7.4 7.4 - 1
Inhibition of human AT1 receptorInhibition of human AT1 receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/acs.jmedchem.9b01780
DB16266 2920 None 42 Human Binding pIC50 = 7.4 7.4 - 1
Inhibition of human AT1 receptorInhibition of human AT1 receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/acs.jmedchem.9b01780
15654759 204099 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 453 8 3 7 4.5 CCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL70242 204099 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 453 8 3 7 4.5 CCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
197647 118084 None 6 Bovine Binding pIC50 = 6.4 6.4 - 0
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 396 6 1 6 4.3 CCOc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81118-5
CHEMBL340612 118084 None 6 Bovine Binding pIC50 = 6.4 6.4 - 0
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 396 6 1 6 4.3 CCOc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81118-5
44323090 106567 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 454 8 2 6 5.0 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCCC2)cc1 10.1021/jm00092a017
CHEMBL314220 106567 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 454 8 2 6 5.0 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCCC2)cc1 10.1021/jm00092a017
127028620 137519 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 550 8 3 7 5.3 CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3754198 137519 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 550 8 3 7 5.3 CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
135723837 101667 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 458 6 2 8 4.9 CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
CHEMBL299269 101667 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 458 6 2 8 4.9 CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
10027681 18889 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 469 12 2 4 7.4 CCCCCNc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1021/jm00077a007
CHEMBL128340 18889 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 469 12 2 4 7.4 CCCCCNc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1021/jm00077a007
54768876 65117 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 521 8 1 8 4.9 CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(C)cc1 10.1016/j.ejmech.2011.05.056
CHEMBL1824002 65117 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 521 8 1 8 4.9 CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(C)cc1 10.1016/j.ejmech.2011.05.056
15654745 203919 None 0 Bovine Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 452 7 2 6 5.1 CCC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL69124 203919 None 0 Bovine Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 452 7 2 6 5.1 CCC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
22850669 202984 None 0 Rabbit Binding pIC50 = 4.4 4.4 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL63109 202984 None 0 Rabbit Binding pIC50 = 4.4 4.4 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44274734 91203 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 464 8 1 6 5.2 CCCCc1nc2ccc(CC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL23994 91203 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 464 8 1 6 5.2 CCCCc1nc2ccc(CC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
9955424 165122 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 450 7 1 6 4.9 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL422756 165122 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 450 7 1 6 4.9 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
10049809 113397 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 458 9 2 5 4.1 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL331859 113397 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 458 9 2 5 4.1 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
44274823 99073 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 10 2 8 5.8 CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL280526 99073 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 10 2 8 5.8 CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
44277677 99318 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 585 9 1 9 5.5 CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL282168 99318 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 585 9 1 9 5.5 CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
9955424 165122 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 450 7 1 6 4.9 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL422756 165122 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 450 7 1 6 4.9 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
19889336 179368 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 410 6 1 7 4.0 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2-c2nn[nH]n2)cc1 10.1021/jm031100t
CHEMBL47382 179368 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 410 6 1 7 4.0 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2-c2nn[nH]n2)cc1 10.1021/jm031100t
18950592 16788 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 10.1021/jm00075a033
CHEMBL124541 16788 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 10.1021/jm00075a033
44285370 139243 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 388 6 1 5 3.9 CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL37892 139243 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 388 6 1 5 3.9 CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
44209671 93600 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 478 8 1 6 5.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL24661 93600 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 478 8 1 6 5.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
19889336 179368 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.
ChEMBL 410 6 1 7 4.0 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80044-X
CHEMBL47382 179368 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.
ChEMBL 410 6 1 7 4.0 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80044-X
44379293 120288 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 611 10 1 6 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL352639 120288 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 611 10 1 6 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1016/S0960-894X(01)81125-2
44315350 105216 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL311484 105216 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
9895984 204747 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
CHEMBL74476 204747 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
44372686 96653 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 600 4 2 7 6.2 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O 10.1021/jm9504722
CHEMBL263714 96653 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 600 4 2 7 6.2 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O 10.1021/jm9504722
14950511 168403 None 0 Guinea pig Binding pIC50 = 8.4 8.4 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 475 8 1 6 5.6 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 10.1021/jm00061a016
CHEMBL434768 168403 None 0 Guinea pig Binding pIC50 = 8.4 8.4 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 475 8 1 6 5.6 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 10.1021/jm00061a016
10074895 19108 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 505 8 1 6 5.8 CCCCc1nc2ccc(N3CCCCC3=O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
CHEMBL128922 19108 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 505 8 1 6 5.8 CCCCc1nc2ccc(N3CCCCC3=O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
10074709 19526 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 500 7 1 5 7.0 CCCc1nc2c(C)cc(-c3cn4ccccc4n3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL129950 19526 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 500 7 1 5 7.0 CCCc1nc2c(C)cc(-c3cn4ccccc4n3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
10053393 50017 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 554 12 2 9 5.4 CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-011-9756-4
CHEMBL156934 50017 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 554 12 2 9 5.4 CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-011-9756-4
14956738 205796 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL83180 205796 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
10053393 50017 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 554 12 2 9 5.4 CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL156934 50017 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 554 12 2 9 5.4 CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
10026681 17937 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 448 10 2 7 3.1 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 10.1007/s00044-009-9205-9
CHEMBL125940 17937 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 448 10 2 7 3.1 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 10.1007/s00044-009-9205-9
10483597 163387 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 592 13 0 9 5.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)s2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL419421 163387 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 592 13 0 9 5.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)s2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
44320509 206336 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 465 6 2 6 5.5 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 10.1021/jm031100t
CHEMBL87327 206336 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 465 6 2 6 5.5 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 10.1021/jm031100t
9915892 103616 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL308703 103616 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
9915892 103616 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL308703 103616 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
71652858 89152 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 623 12 3 8 5.4 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2337677 89152 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 623 12 3 8 5.4 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2365958 89152 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 623 12 3 8 5.4 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
44275097 99331 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 585 10 2 8 6.4 CCCCc1nc2ccc(NC(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL282236 99331 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 585 10 2 8 6.4 CCCCc1nc2ccc(NC(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
57380414 70528 None 0 Human Binding pIC50 = 8.4 8.4 - 1
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947131 70528 None 0 Human Binding pIC50 = 8.4 8.4 - 1
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
19754062 102983 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 604 13 3 7 5.9 CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL306641 102983 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 604 13 3 7 5.9 CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
44377067 56561 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 495 10 2 6 4.0 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL164059 56561 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 495 10 2 6 4.0 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
10031920 107985 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 10.1021/jm00043a020
CHEMBL319404 107985 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 10.1021/jm00043a020
10078554 116966 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338687 116966 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44305424 102491 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 388 6 2 6 2.4 CCCc1cc(=O)[nH]c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL304032 102491 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 388 6 2 6 2.4 CCCc1cc(=O)[nH]c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
136093942 139092 None 0 Rat Binding pIC50 = 8.4 8.4 - 1
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 436 8 1 6 4.8 CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmc.2016.03.028
CHEMBL3786570 139092 None 0 Rat Binding pIC50 = 8.4 8.4 - 1
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 436 8 1 6 4.8 CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmc.2016.03.028
44277567 101395 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 605 8 0 10 4.9 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL29725 101395 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 605 8 0 10 4.9 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
44379184 57447 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 602 14 2 7 5.9 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL165541 57447 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 602 14 2 7 5.9 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1016/S0960-894X(01)81125-2
14951067 203493 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 489 12 1 9 3.6 CCCCc1nn(CCCCC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL66173 203493 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 489 12 1 9 3.6 CCCCc1nn(CCCCC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
44305680 102746 None 0 Bovine Binding pIC50 = 8.4 8.4 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 561 9 1 9 3.2 CCCc1cc(=O)n(CCN2C(=O)c3ccccc3C2=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL305032 102746 None 0 Bovine Binding pIC50 = 8.4 8.4 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 561 9 1 9 3.2 CCCc1cc(=O)n(CCN2C(=O)c3ccccc3C2=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
44277937 101412 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 584 10 0 9 5.5 CCCCCN(C(=O)c1cccnc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL29734 101412 None 0 Rabbit Binding pIC50 = 8.4 8.4 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 584 10 0 9 5.5 CCCCCN(C(=O)c1cccnc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
44211708 100678 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 416 7 1 7 2.8 CCCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL292316 100678 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 416 7 1 7 2.8 CCCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
10183373 165008 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 465 9 1 7 4.3 CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL422593 165008 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 465 9 1 7 4.3 CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44277420 101108 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 603 8 0 8 6.1 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL29512 101108 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 603 8 0 8 6.1 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
9847539 182037 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 470 8 1 5 5.8 CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL47810 182037 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 470 8 1 5 5.8 CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81140-9
44309701 103184 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 609 11 2 7 6.3 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL308238 103184 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 609 11 2 7 6.3 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
10349897 114426 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL333224 114426 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10350123 57601 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 713 12 1 9 6.0 CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F 10.1016/j.bmc.2010.10.043
CHEMBL1668007 57601 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 713 12 1 9 6.0 CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F 10.1016/j.bmc.2010.10.043
10460346 207486 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 555 9 1 7 4.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC#N)cc1 10.1021/jm00043a020
CHEMBL94407 207486 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 555 9 1 7 4.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC#N)cc1 10.1021/jm00043a020
10007306 117182 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 534 12 0 7 5.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL339404 117182 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 534 12 0 7 5.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
10325483 16378 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 560 12 2 8 5.1 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(O)c(O)c2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL122982 16378 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 560 12 2 8 5.1 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(O)c(O)c2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
10478294 114108 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 438 10 2 5 3.9 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL332766 114108 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 438 10 2 5 3.9 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
14956794 206076 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 479 9 1 7 4.9 CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL85545 206076 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 479 9 1 7 4.9 CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44338834 7856 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL108981 7856 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
44277871 99698 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 599 10 1 9 5.8 CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL28464 99698 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 599 10 1 9 5.8 CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
44277594 101801 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 619 8 1 9 5.9 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL30015 101801 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 619 8 1 9 5.9 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
9935096 207769 None 1 Human Binding pIC50 = 8.3 8.3 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 485 8 1 7 5.3 CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 10.1016/j.bmc.2010.10.043
CHEMBL9599 207769 None 1 Human Binding pIC50 = 8.3 8.3 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 485 8 1 7 5.3 CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 10.1016/j.bmc.2010.10.043
44338834 7856 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL108981 7856 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
73350991 92622 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 8 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)c3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435826 92622 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 8 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)c3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
10670376 172045 None 0 Bovine Binding pIC50 = 8.3 8.3 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 432 8 3 7 3.5 CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
CHEMBL447182 172045 None 0 Bovine Binding pIC50 = 8.3 8.3 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 432 8 3 7 3.5 CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
44294905 189147 None 0 Bovine Binding pIC50 = 7.4 7.4 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 485 6 1 6 5.1 CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80474-6
CHEMBL51084 189147 None 0 Bovine Binding pIC50 = 7.4 7.4 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 485 6 1 6 5.1 CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80474-6
76326259 84972 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 598 12 2 10 4.2 CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237606 84972 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 598 12 2 10 4.2 CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
44311429 204614 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 649 11 1 8 6.8 CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL73369 204614 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 649 11 1 8 6.8 CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10053412 51321 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 555 11 1 9 4.6 CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL158115 51321 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 555 11 1 9 4.6 CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
1610 2345 None 95 Rabbit Binding pIC50 = 7.4 7.4 -1 4
Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneDisplacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1039/d2md00206j
3941 2345 None 95 Rabbit Binding pIC50 = 7.4 7.4 -1 4
Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneDisplacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1039/d2md00206j
3961 2345 None 95 Rabbit Binding pIC50 = 7.4 7.4 -1 4
Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneDisplacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1039/d2md00206j
590 2345 None 95 Rabbit Binding pIC50 = 7.4 7.4 -1 4
Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneDisplacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1039/d2md00206j
CHEMBL191 2345 None 95 Rabbit Binding pIC50 = 7.4 7.4 -1 4
Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneDisplacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1039/d2md00206j
DB00678 2345 None 95 Rabbit Binding pIC50 = 7.4 7.4 -1 4
Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membraneDisplacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1039/d2md00206j
9909335 118456 None 0 Guinea pig Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 407 5 1 5 5.5 Cc1cc(OC(C)c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00100a007
CHEMBL341223 118456 None 0 Guinea pig Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 407 5 1 5 5.5 Cc1cc(OC(C)c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm00100a007
1610 2345 None 95 Rabbit Binding pIC50 = 7.4 7.4 -1 4
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
3941 2345 None 95 Rabbit Binding pIC50 = 7.4 7.4 -1 4
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
3961 2345 None 95 Rabbit Binding pIC50 = 7.4 7.4 -1 4
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
590 2345 None 95 Rabbit Binding pIC50 = 7.4 7.4 -1 4
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
CHEMBL191 2345 None 95 Rabbit Binding pIC50 = 7.4 7.4 -1 4
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
DB00678 2345 None 95 Rabbit Binding pIC50 = 7.4 7.4 -1 4
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
44305446 100749 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 473 9 2 8 2.0 CCCc1cc(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL292781 100749 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 473 9 2 8 2.0 CCCc1cc(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
10369479 118491 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 522 15 0 6 6.0 CCCCCCN1C(=O)N(CCCC)C(=O)/C1=C/c1cnc(CCCC)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL341456 118491 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 522 15 0 6 6.0 CCCCCCN1C(=O)N(CCCC)C(=O)/C1=C/c1cnc(CCCC)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
127035715 136438 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 545 10 2 4 7.2 CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735652 136438 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 545 10 2 4 7.2 CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
76326258 84969 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 480 9 2 9 2.5 CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237603 84969 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 480 9 2 9 2.5 CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
44323084 206501 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 440 8 2 6 4.6 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCC2)cc1 10.1021/jm00092a017
CHEMBL88350 206501 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissueConcentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
ChEMBL 440 8 2 6 4.6 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCC2)cc1 10.1021/jm00092a017
10094614 49260 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 437 8 1 8 2.9 CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL156307 49260 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 437 8 1 8 2.9 CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
15144940 118150 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 453 10 1 5 5.5 CCCCc1ncc(/C=C(\Cc2ccc([N+](=O)[O-])cc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
CHEMBL340825 118150 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 453 10 1 5 5.5 CCCCc1ncc(/C=C(\Cc2ccc([N+](=O)[O-])cc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
4110026 204933 None 1 Rat Binding pIC50 = 6.4 6.4 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 384 7 1 3 5.8 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL7632 204933 None 1 Rat Binding pIC50 = 6.4 6.4 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 384 7 1 3 5.8 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
44298869 101608 None 0 Bovine Binding pIC50 = 5.4 5.4 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 452 7 1 7 4.2 CCCOc1nc2cc(C)ccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
CHEMBL298836 101608 None 0 Bovine Binding pIC50 = 5.4 5.4 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 452 7 1 7 4.2 CCCOc1nc2cc(C)ccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
44298545 195927 None 0 Bovine Binding pIC50 = 5.4 5.4 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 466 7 1 7 4.5 Cc1ccc2nc(OCC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 10.1016/S0960-894X(01)81144-6
CHEMBL55939 195927 None 0 Bovine Binding pIC50 = 5.4 5.4 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 466 7 1 7 4.5 Cc1ccc2nc(OCC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 10.1016/S0960-894X(01)81144-6
11167180 165421 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 464 7 1 5 6.4 CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 10.1021/jm031100t
CHEMBL423861 165421 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 464 7 1 5 6.4 CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 10.1021/jm031100t
71521300 86823 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 519 6 1 7 5.7 CCc1nc2ccn(CC3CCCCC3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322442 86823 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 519 6 1 7 5.7 CCc1nc2ccn(CC3CCCCC3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
44438872 169104 None 0 Bovine Binding pIC50 = 7.4 7.4 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 455 8 1 8 4.2 CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL440051 169104 None 0 Bovine Binding pIC50 = 7.4 7.4 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 455 8 1 8 4.2 CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
10391950 115110 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 520 12 1 9 3.2 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2nn[nH]n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL334326 115110 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 520 12 1 9 3.2 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2nn[nH]n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
44307258 203652 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 478 5 1 4 5.3 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1cc(Br)c(O)c(Br)c1 10.1016/S0960-894X(01)81148-3
CHEMBL67309 203652 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 478 5 1 4 5.3 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1cc(Br)c(O)c(Br)c1 10.1016/S0960-894X(01)81148-3
44341787 109780 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 416 5 1 3 5.3 O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2C2CCCC2)cc1 10.1021/jm00074a018
CHEMBL323244 109780 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 416 5 1 3 5.3 O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2C2CCCC2)cc1 10.1021/jm00074a018
15780094 99808 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 651 9 1 7 7.4 CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL285433 99808 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 651 9 1 7 7.4 CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
70684248 76276 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 541 9 2 6 6.1 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058588 76276 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 541 9 2 6 6.1 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
15699053 108804 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 396 7 2 6 3.8 CCCCc1nc(Cl)c(CO)n1Cc1cccc2cc(-c3nn[nH]n3)ccc12 10.1021/jm00114a021
CHEMBL320951 108804 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 396 7 2 6 3.8 CCCCc1nc(Cl)c(CO)n1Cc1cccc2cc(-c3nn[nH]n3)ccc12 10.1021/jm00114a021
71717082 89147 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 623 12 3 8 5.4 CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2337683 89147 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 623 12 3 8 5.4 CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2365904 89147 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 623 12 3 8 5.4 CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
127035069 136397 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 663 11 2 8 7.7 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735300 136397 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 663 11 2 8 7.7 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
9985434 50296 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 568 11 2 6 6.9 CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL157185 50296 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 568 11 2 6 6.9 CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
127035379 136505 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 691 13 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736248 136505 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 691 13 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
135987614 100698 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 455 7 3 8 4.6 CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
CHEMBL292430 100698 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 455 7 3 8 4.6 CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
44283480 100466 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 637 9 1 8 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL290768 100466 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 637 9 1 8 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
9985434 50296 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 568 11 2 6 6.9 CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL157185 50296 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 568 11 2 6 6.9 CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
44297114 101799 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 561 8 1 8 5.9 CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN3O4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL300105 101799 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 561 8 1 8 5.9 CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN3O4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
44297216 186819 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 575 8 1 9 4.9 CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL48934 186819 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 575 8 1 9 4.9 CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
14956775 203979 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 375 7 2 7 3.2 CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL69508 203979 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 375 7 2 7 3.2 CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
15287883 98208 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 415 8 1 5 4.9 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(94)00476-V
CHEMBL274260 98208 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 415 8 1 5 4.9 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(94)00476-V
71654382 89143 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 701 12 3 8 6.2 CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2337681 89143 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 701 12 3 8 6.2 CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2365830 89143 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 701 12 3 8 6.2 CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
1610 2345 None 95 Bovine Binding pIC50 = 6.4 6.4 - 4
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80474-6
3941 2345 None 95 Bovine Binding pIC50 = 6.4 6.4 - 4
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80474-6
3961 2345 None 95 Bovine Binding pIC50 = 6.4 6.4 - 4
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80474-6
590 2345 None 95 Bovine Binding pIC50 = 6.4 6.4 - 4
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80474-6
CHEMBL191 2345 None 95 Bovine Binding pIC50 = 6.4 6.4 - 4
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80474-6
DB00678 2345 None 95 Bovine Binding pIC50 = 6.4 6.4 - 4
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80474-6
135415867 560 None 97 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 10.1016/0960-894X(95)00319-O
6901 560 None 97 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 10.1016/0960-894X(95)00319-O
CHEMBL57242 560 None 97 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 10.1016/0960-894X(95)00319-O
135487973 199146 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 454 7 2 7 5.2 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
CHEMBL58938 199146 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 454 7 2 7 5.2 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
11511750 96553 None 1 Rabbit Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 483 10 2 6 4.6 CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL262958 96553 None 1 Rabbit Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 483 10 2 6 4.6 CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
15698116 167734 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 388 8 2 5 4.4 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2occc2C(=O)O)cc1 10.1021/jm00053a013
CHEMBL430279 167734 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 388 8 2 5 4.4 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2occc2C(=O)O)cc1 10.1021/jm00053a013
1610 2345 None 95 Bovine Binding pIC50 = 6.4 6.4 - 4
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80914-8
3941 2345 None 95 Bovine Binding pIC50 = 6.4 6.4 - 4
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80914-8
3961 2345 None 95 Bovine Binding pIC50 = 6.4 6.4 - 4
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80914-8
590 2345 None 95 Bovine Binding pIC50 = 6.4 6.4 - 4
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80914-8
CHEMBL191 2345 None 95 Bovine Binding pIC50 = 6.4 6.4 - 4
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80914-8
DB00678 2345 None 95 Bovine Binding pIC50 = 6.4 6.4 - 4
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80914-8
24827903 95983 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 477 7 1 7 4.7 CCCCn1c(=O)c2cc(F)c(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL259575 95983 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 477 7 1 7 4.7 CCCCn1c(=O)c2cc(F)c(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
14956743 164103 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL420970 164103 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44297046 168186 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 551 9 2 9 4.3 CCCCc1nc2ccc([C@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL433278 168186 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 551 9 2 9 4.3 CCCCc1nc2ccc([C@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
14951088 203944 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 521 10 1 8 4.9 CCCCc1nn(C(C)(C)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL69296 203944 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 521 10 1 8 4.9 CCCCc1nn(C(C)(C)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
130762 98245 None 9 Guinea pig Binding pIC50 = 6.4 6.4 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00100a007
CHEMBL274447 98245 None 9 Guinea pig Binding pIC50 = 6.4 6.4 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00100a007
3082918 95067 None 1 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 340 7 1 3 4.2 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
CHEMBL25528 95067 None 1 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 340 7 1 3 4.2 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
127028619 137493 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 550 11 3 7 5.3 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 10.1039/C5MD00169B
CHEMBL3754010 137493 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 550 11 3 7 5.3 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 10.1039/C5MD00169B
10478476 103044 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
ChEMBL 441 6 3 9 1.7 O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm0204237
CHEMBL307191 103044 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
ChEMBL 441 6 3 9 1.7 O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm0204237
44312700 204734 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
ChEMBL 457 6 3 8 2.0 O=C(O)c1nc(CO)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm0204237
CHEMBL74347 204734 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
ChEMBL 457 6 3 8 2.0 O=C(O)c1nc(CO)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm0204237
44301981 100625 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytesCompound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes
ChEMBL 441 5 2 7 2.8 Cc1nc(C(=O)O)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CC2 10.1016/s0960-894x(02)00303-7
CHEMBL291944 100625 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytesCompound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes
ChEMBL 441 5 2 7 2.8 Cc1nc(C(=O)O)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CC2 10.1016/s0960-894x(02)00303-7
10478476 103044 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytesCompound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes
ChEMBL 441 6 3 9 1.7 O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/s0960-894x(02)00303-7
CHEMBL307191 103044 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytesCompound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes
ChEMBL 441 6 3 9 1.7 O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/s0960-894x(02)00303-7
127026043 137351 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 607 11 3 9 3.8 CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752947 137351 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 607 11 3 9 3.8 CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
44300827 101765 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 602 8 1 7 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL299897 101765 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 602 8 1 7 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
44211708 100678 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 416 7 1 7 2.8 CCCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL292316 100678 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 416 7 1 7 2.8 CCCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
44307087 203773 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 401 6 1 5 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81148-3
CHEMBL68111 203773 None 0 Rabbit Binding pIC50 = 6.4 6.4 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 401 6 1 5 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81148-3
9843116 113501 None 84 Rat Binding pIC50 = 6.4 6.4 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 385 6 0 3 5.5 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C#N)cc1 10.1021/jm00074a018
CHEMBL332051 113501 None 84 Rat Binding pIC50 = 6.4 6.4 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 385 6 0 3 5.5 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C#N)cc1 10.1021/jm00074a018
19792146 101900 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 500 8 1 7 5.7 CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL300861 101900 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 500 8 1 7 5.7 CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
15069407 189641 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL51508 189641 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
10047444 100345 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 414 9 1 4 5.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
CHEMBL289543 100345 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 414 9 1 4 5.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
15654700 163754 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 470 7 1 8 4.8 CCSc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL420551 163754 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 470 7 1 8 4.8 CCSc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
15654749 203828 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 454 8 2 7 4.2 CCOCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL68494 203828 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 454 8 2 7 4.2 CCOCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
14952903 195573 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Tested for binding affinity to Angiotensin II receptor, type 1Tested for binding affinity to Angiotensin II receptor, type 1
ChEMBL 380 9 1 4 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1 10.1016/S0960-894X(01)81116-1
CHEMBL55508 195573 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Tested for binding affinity to Angiotensin II receptor, type 1Tested for binding affinity to Angiotensin II receptor, type 1
ChEMBL 380 9 1 4 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1 10.1016/S0960-894X(01)81116-1
15069407 189641 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL51508 189641 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
19792146 101900 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 500 8 1 7 5.7 CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL300861 101900 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 500 8 1 7 5.7 CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
44298808 101980 None 0 Bovine Binding pIC50 = 5.4 5.4 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 424 6 1 7 3.5 CCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
CHEMBL301479 101980 None 0 Bovine Binding pIC50 = 5.4 5.4 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 424 6 1 7 3.5 CCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
10255888 76634 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 514 8 2 6 4.2 CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
CHEMBL2063982 76634 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 514 8 2 6 4.2 CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
10255888 76634 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 514 8 2 6 4.2 CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
CHEMBL2063982 76634 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 514 8 2 6 4.2 CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
44210836 56507 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Binding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assayBinding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assay
ChEMBL 453 6 1 8 3.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 10.1016/S0960-894X(01)80193-1
CHEMBL163523 56507 None 0 Rabbit Binding pIC50 = 7.4 7.4 - 0
Binding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assayBinding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assay
ChEMBL 453 6 1 8 3.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 10.1016/S0960-894X(01)80193-1
70694736 76211 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 472 6 1 6 5.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(C)nc4ccccc43)cc2)c1C 10.1016/j.bmc.2012.06.011
CHEMBL2058367 76211 None 0 Bovine Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 472 6 1 6 5.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(C)nc4ccccc43)cc2)c1C 10.1016/j.bmc.2012.06.011
14951085 103185 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 537 13 1 8 5.5 CCCCc1nn(CC(OCCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL308239 103185 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 537 13 1 8 5.5 CCCCc1nn(CC(OCCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
71521506 86805 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 514 6 1 8 4.6 CCc1nc2ccn(Cc3cccnc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322172 86805 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 514 6 1 8 4.6 CCc1nc2ccn(Cc3cccnc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
19792159 193278 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 2 6 4.8 CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL52398 193278 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 2 6 4.8 CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
19792159 193278 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 2 6 4.8 CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL52398 193278 None 0 Bovine Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 2 6 4.8 CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
44296550 188798 None 0 Bovine Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 407 9 2 4 4.7 CCCc1cc(COC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
CHEMBL50592 188798 None 0 Bovine Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 407 9 2 4 4.7 CCCc1cc(COC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
CHEMBL86558 206207 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Displacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranesDisplacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranes
ChEMBL 414 8 1 5 4.7 CCCCN1N=C(CCC)/C(=C/c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O 10.1016/S0960-894X(01)80290-0
10642524 9617 None 1 Bovine Binding pIC50 = 4.4 4.4 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 364 7 2 4 3.9 CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL112637 9617 None 1 Bovine Binding pIC50 = 4.4 4.4 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 364 7 2 4 3.9 CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
44303859 200989 None 0 Rabbit Binding pIC50 = 4.4 4.4 - 0
Inhibition of Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 514 8 1 3 5.8 CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL60209 200989 None 0 Rabbit Binding pIC50 = 4.4 4.4 - 0
Inhibition of Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 514 8 1 3 5.8 CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 10.1016/S0960-894X(01)81007-6
15654716 103783 None 0 Bovine Binding pIC50 = 4.4 4.4 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(C(=O)O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL308911 103783 None 0 Bovine Binding pIC50 = 4.4 4.4 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(C(=O)O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
10047444 100345 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Tested for binding affinity to Angiotensin II receptor, type 1Tested for binding affinity to Angiotensin II receptor, type 1
ChEMBL 414 9 1 4 5.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl 10.1016/S0960-894X(01)81116-1
CHEMBL289543 100345 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Tested for binding affinity to Angiotensin II receptor, type 1Tested for binding affinity to Angiotensin II receptor, type 1
ChEMBL 414 9 1 4 5.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl 10.1016/S0960-894X(01)81116-1
9910561 10045 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 430 8 2 6 4.6 CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
CHEMBL115206 10045 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 430 8 2 6 4.6 CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
9867026 203926 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 424 6 2 6 4.2 CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL69154 203926 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 424 6 2 6 4.2 CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
10004855 116723 None 0 Guinea pig Binding pIC50 = 6.3 6.3 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 432 6 1 6 5.1 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C#N)cc2n1 10.1021/jm00100a007
CHEMBL337380 116723 None 0 Guinea pig Binding pIC50 = 6.3 6.3 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 432 6 1 6 5.1 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C#N)cc2n1 10.1021/jm00100a007
10094851 21295 None 0 Rat Binding pIC50 = 6.3 6.3 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 441 8 2 4 5.8 CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL131365 21295 None 0 Rat Binding pIC50 = 6.3 6.3 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 441 8 2 4 5.8 CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
15699075 5420 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 390 7 2 4 4.0 CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(C)(C(=O)O)C2 10.1021/jm00114a021
CHEMBL107271 5420 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 390 7 2 4 4.0 CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(C)(C(=O)O)C2 10.1021/jm00114a021
10621927 110860 None 0 Bovine Binding pIC50 = 5.3 5.3 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 418 8 3 7 2.9 CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
CHEMBL326086 110860 None 0 Bovine Binding pIC50 = 5.3 5.3 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 418 8 3 7 2.9 CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
10094965 18921 None 0 Guinea pig Binding pIC50 = 5.3 5.3 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 407 5 1 5 5.3 Cc1nc2ccccc2c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C 10.1021/jm00100a007
CHEMBL128536 18921 None 0 Guinea pig Binding pIC50 = 5.3 5.3 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 407 5 1 5 5.3 Cc1nc2ccccc2c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C 10.1021/jm00100a007
24828708 159739 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 459 7 1 7 4.5 CCCCn1c2nc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL410487 159739 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 459 7 1 7 4.5 CCCCn1c2nc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
127037496 136401 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 613 12 2 7 6.9 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 10.1039/C4MD00499J
CHEMBL3735311 136401 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 613 12 2 7 6.9 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 10.1039/C4MD00499J
44341792 110583 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 420 7 1 4 4.5 CCCCC1=NC2(CCOCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL325445 110583 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 420 7 1 4 4.5 CCCCC1=NC2(CCOCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
127035067 136390 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 683 12 2 9 5.4 CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735236 136390 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 683 12 2 9 5.4 CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10482340 17643 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 537 11 0 9 4.2 CCCCc1ncc(/C=C2/C(=O)N(COC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL125835 17643 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 537 11 0 9 4.2 CCCCc1ncc(/C=C2/C(=O)N(COC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
10325295 118176 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 551 12 1 9 4.0 CCCCc1ncc(/C=C2/C(=O)N(CCCO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL340882 118176 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 551 12 1 9 4.0 CCCCc1ncc(/C=C2/C(=O)N(CCCO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
44295090 101652 None 0 Bovine Binding pIC50 = 6.3 6.3 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 487 9 1 6 5.3 CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(00)80474-6
CHEMBL299151 101652 None 0 Bovine Binding pIC50 = 6.3 6.3 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 487 9 1 6 5.3 CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(00)80474-6
10343392 20152 None 0 Guinea pig Binding pIC50 = 6.3 6.3 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 407 5 1 5 5.3 Cc1ccc2nc(C)cc(OCc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1021/jm00100a007
CHEMBL130455 20152 None 0 Guinea pig Binding pIC50 = 6.3 6.3 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 407 5 1 5 5.3 Cc1ccc2nc(C)cc(OCc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1021/jm00100a007
44309268 203863 None 0 Bovine Binding pIC50 = 5.3 5.3 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 308 5 1 3 4.8 CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(C)c1 10.1016/S0960-894X(01)81149-5
CHEMBL68713 203863 None 0 Bovine Binding pIC50 = 5.3 5.3 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 308 5 1 3 4.8 CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(C)c1 10.1016/S0960-894X(01)81149-5
76329884 84970 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 590 11 2 9 4.7 CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237604 84970 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 590 11 2 9 4.7 CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
44210646 19104 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 427 7 2 7 3.7 CCCc1cn2ncc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81118-5
CHEMBL128920 19104 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 427 7 2 7 3.7 CCCc1cn2ncc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81118-5
10395045 119732 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 547 10 1 8 5.1 CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL347630 119732 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 547 10 1 8 5.1 CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
44317214 104757 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Tested for inhibition of Angiotensin II specific binding to Angiotensin II receptor, type 1 in the recombinant human AT-1 receptor expressed in LhAT-1D6 cellsTested for inhibition of Angiotensin II specific binding to Angiotensin II receptor, type 1 in the recombinant human AT-1 receptor expressed in LhAT-1D6 cells
ChEMBL 474 12 4 5 4.2 CCCCc1ncc(CN[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1016/0960-894X(94)00456-P
CHEMBL310752 104757 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Tested for inhibition of Angiotensin II specific binding to Angiotensin II receptor, type 1 in the recombinant human AT-1 receptor expressed in LhAT-1D6 cellsTested for inhibition of Angiotensin II specific binding to Angiotensin II receptor, type 1 in the recombinant human AT-1 receptor expressed in LhAT-1D6 cells
ChEMBL 474 12 4 5 4.2 CCCCc1ncc(CN[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1016/0960-894X(94)00456-P
10072403 17076 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 449 11 1 9 3.9 CCCCc1nc(CCCC)n(Cc2ccc(-n3cc([N+](=O)[O-])cc3-c3nn[nH]n3)cc2)n1 10.1021/jm00053a013
CHEMBL12548 17076 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 449 11 1 9 3.9 CCCCc1nc(CCCC)n(Cc2ccc(-n3cc([N+](=O)[O-])cc3-c3nn[nH]n3)cc2)n1 10.1021/jm00053a013
11744700 119679 None 0 Rabbit Binding pIC50 = 6.3 6.3 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 454 11 3 7 3.7 CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL347234 119679 None 0 Rabbit Binding pIC50 = 6.3 6.3 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 454 11 3 7 3.7 CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44341608 110659 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 567 9 2 5 5.4 CCCCC1=NC2(CCN(C(=O)c3ccccc3C(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL325905 110659 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 567 9 2 5 5.4 CCCCC1=NC2(CCN(C(=O)c3ccccc3C(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
135723851 100821 None 0 Bovine Binding pIC50 = 6.3 6.3 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 472 7 2 8 5.3 CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
CHEMBL293308 100821 None 0 Bovine Binding pIC50 = 6.3 6.3 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 472 7 2 8 5.3 CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
11744700 119679 None 0 Rabbit Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 454 11 3 7 3.7 CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL347234 119679 None 0 Rabbit Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 454 11 3 7 3.7 CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
10408577 21812 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 398 7 1 3 6.1 CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL131948 21812 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 398 7 1 3 6.1 CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
10253216 50717 None 0 Rabbit Binding pIC50 = 5.3 5.3 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 450 7 2 6 4.4 CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL157597 50717 None 0 Rabbit Binding pIC50 = 5.3 5.3 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 450 7 2 6 4.4 CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
10253216 50717 None 0 Rabbit Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 450 7 2 6 4.4 CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL157597 50717 None 0 Rabbit Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 450 7 2 6 4.4 CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
127035392 136497 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 563 10 2 5 7.4 CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3736202 136497 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 563 10 2 5 7.4 CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
11757293 119837 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 550 11 2 6 7.1 CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL348568 119837 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 550 11 2 6 7.1 CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44341756 9959 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 523 8 1 4 5.7 CCCCC1=NC2(CCN(C(=O)c3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL114720 9959 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 523 8 1 4 5.7 CCCCC1=NC2(CCN(C(=O)c3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
11757293 119837 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 550 11 2 6 7.1 CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL348568 119837 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 550 11 2 6 7.1 CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
14956799 106897 None 0 Rabbit Binding pIC50 = 6.3 6.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 509 10 2 8 4.0 CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL314590 106897 None 0 Rabbit Binding pIC50 = 6.3 6.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 509 10 2 8 4.0 CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
130762 98245 None 9 Bovine Binding pIC50 = 6.3 6.3 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL274447 98245 None 9 Bovine Binding pIC50 = 6.3 6.3 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
130762 98245 None 9 Bovine Binding pIC50 = 6.3 6.3 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
CHEMBL274447 98245 None 9 Bovine Binding pIC50 = 6.3 6.3 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
15654730 204238 None 0 Bovine Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 6 1 8 3.7 COC(=O)c1cccc2nc(OC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 10.1021/jm00067a016
CHEMBL71038 204238 None 0 Bovine Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 6 1 8 3.7 COC(=O)c1cccc2nc(OC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 10.1021/jm00067a016
44298546 100694 None 0 Bovine Binding pIC50 = 5.3 5.3 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 510 8 1 9 4.1 CCOC(=O)c1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 10.1016/S0960-894X(01)81144-6
CHEMBL292412 100694 None 0 Bovine Binding pIC50 = 5.3 5.3 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 510 8 1 9 4.1 CCOC(=O)c1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 10.1016/S0960-894X(01)81144-6
11785963 205833 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 535 10 1 6 7.2 CCCN(CCC)c1nc2ccccc2c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1C(=O)O 10.1021/jm031100t
CHEMBL83452 205833 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 535 10 1 6 7.2 CCCN(CCC)c1nc2ccccc2c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1C(=O)O 10.1021/jm031100t
127036105 136516 None 0 Human Binding pIC50 = 6.3 6.3 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 547 10 3 5 6.2 CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3736336 136516 None 0 Human Binding pIC50 = 6.3 6.3 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 547 10 3 5 6.2 CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
44209951 92178 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 466 8 1 7 4.6 CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL24240 92178 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 466 8 1 7 4.6 CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
44209671 93600 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 478 8 1 6 5.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL24661 93600 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 478 8 1 6 5.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
44274671 94232 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 479 8 1 7 4.7 CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL25000 94232 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 479 8 1 7 4.7 CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
14956748 205971 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL84627 205971 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44209951 92178 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 466 8 1 7 4.6 CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL24240 92178 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 466 8 1 7 4.6 CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
1610 2345 None 95 Rat Binding pIC50 = 8.3 8.3 -1 4
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00064a007
3941 2345 None 95 Rat Binding pIC50 = 8.3 8.3 -1 4
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00064a007
3961 2345 None 95 Rat Binding pIC50 = 8.3 8.3 -1 4
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00064a007
590 2345 None 95 Rat Binding pIC50 = 8.3 8.3 -1 4
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00064a007
CHEMBL191 2345 None 95 Rat Binding pIC50 = 8.3 8.3 -1 4
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00064a007
DB00678 2345 None 95 Rat Binding pIC50 = 8.3 8.3 -1 4
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00064a007
9870463 102247 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 495 5 1 6 4.8 CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 10.1016/S0960-894X(01)81148-3
CHEMBL303147 102247 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 495 5 1 6 4.8 CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 10.1016/S0960-894X(01)81148-3
9887844 163198 None 4 Guinea pig Binding pIC50 = 8.3 8.3 - 1
Binding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranes
ChEMBL 411 6 1 5 4.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/j.bmc.2010.10.043
CHEMBL418226 163198 None 4 Guinea pig Binding pIC50 = 8.3 8.3 - 1
Binding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in guinea pig adrenal cortex membranes
ChEMBL 411 6 1 5 4.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/j.bmc.2010.10.043
9870463 102247 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
ChEMBL 495 5 1 6 4.8 CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 10.1016/j.bmc.2010.10.043
CHEMBL303147 102247 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
ChEMBL 495 5 1 6 4.8 CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 10.1016/j.bmc.2010.10.043
9887844 163198 None 4 Guinea pig Binding pIC50 = 8.3 8.3 - 1
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 411 6 1 5 4.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
CHEMBL418226 163198 None 4 Guinea pig Binding pIC50 = 8.3 8.3 - 1
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 411 6 1 5 4.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
131654 206401 None 12 Rat Binding pIC50 = 8.3 8.3 - 1
Displacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranesDisplacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranes
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80290-0
CHEMBL87778 206401 None 12 Rat Binding pIC50 = 8.3 8.3 - 1
Displacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranesDisplacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranes
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80290-0
44275108 94747 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 513 8 1 7 5.7 CCCCc1nc2ccc(-c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL25313 94747 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 513 8 1 7 5.7 CCCCc1nc2ccc(-c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
127035717 136414 None 0 Human Binding pIC50 = 8.3 8.3 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735409 136414 None 0 Human Binding pIC50 = 8.3 8.3 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
10053595 103114 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 562 10 2 8 4.8 CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL307756 103114 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 562 10 2 8 4.8 CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311738 204189 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 590 10 2 8 4.4 CCCc1nc(CN2CCN(C(=O)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70801 204189 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 590 10 2 8 4.4 CCCc1nc(CN2CCN(C(=O)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44379334 58109 None 1 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 585 10 2 9 4.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL167584 58109 None 1 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 585 10 2 9 4.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81125-2
10054912 207630 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 10.1021/jm00043a020
CHEMBL95197 207630 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 10.1021/jm00043a020
44373417 52381 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 10.1021/jm9504722
CHEMBL159004 52381 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 10.1021/jm9504722
14950508 99569 None 0 Guinea pig Binding pIC50 = 8.3 8.3 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 429 7 1 7 4.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 10.1021/jm00061a016
CHEMBL283742 99569 None 0 Guinea pig Binding pIC50 = 8.3 8.3 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 429 7 1 7 4.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 10.1021/jm00061a016
15171368 168064 None 0 Guinea pig Binding pIC50 = 8.3 8.3 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 443 8 1 7 4.4 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(CC)n1 10.1021/jm00061a016
CHEMBL432459 168064 None 0 Guinea pig Binding pIC50 = 8.3 8.3 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 443 8 1 7 4.4 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(CC)n1 10.1021/jm00061a016
10480536 21627 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 485 7 1 6 6.3 CCCc1nc2c(C)cc(-c3ccccn3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
CHEMBL131767 21627 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 485 7 1 6 6.3 CCCc1nc2c(C)cc(-c3ccccn3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
10481936 116695 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 524 7 1 7 6.4 CCCc1nc2ccc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
CHEMBL337232 116695 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 524 7 1 7 6.4 CCCc1nc2ccc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
15287890 155769 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 429 8 1 5 5.3 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 10.1016/0960-894X(94)00476-V
CHEMBL40585 155769 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 429 8 1 5 5.3 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 10.1016/0960-894X(94)00476-V
44277574 101899 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL30086 101899 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
15231094 139295 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 641 12 1 8 7.4 CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL37919 139295 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 641 12 1 8 7.4 CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
71521302 86825 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 527 6 1 7 5.5 CCc1nc2ccn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322444 86825 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 527 6 1 7 5.5 CCc1nc2ccn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
131654 206401 None 12 Rat Binding pIC50 = 8.3 8.3 - 1
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL87778 206401 None 12 Rat Binding pIC50 = 8.3 8.3 - 1
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
44348355 113385 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 10.1021/jm00075a033
CHEMBL331797 113385 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 10.1021/jm00075a033
53309406 63779 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 511 6 1 6 6.3 CCc1nc2c(C)cc(Cc3ccccc3)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
CHEMBL1801743 63779 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 511 6 1 6 6.3 CCc1nc2c(C)cc(Cc3ccccc3)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
9847539 182037 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 470 8 1 5 5.8 CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL47810 182037 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 470 8 1 5 5.8 CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81140-9
10349256 111454 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 647 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 10.1021/jm00043a020
CHEMBL327569 111454 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 647 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 10.1021/jm00043a020
44300615 196781 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 572 9 1 7 6.5 CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
CHEMBL56549 196781 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 572 9 1 7 6.5 CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
10257584 17126 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 577 14 0 8 6.2 CCCCCCN1C(=O)/C(=C/c2cnc(CCCC)n2Cc2ccc(C(=O)OC)cc2)N(Cc2csc(C)n2)C1=O 10.1007/s00044-009-9205-9
CHEMBL125533 17126 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 577 14 0 8 6.2 CCCCCCN1C(=O)/C(=C/c2cnc(CCCC)n2Cc2ccc(C(=O)OC)cc2)N(Cc2csc(C)n2)C1=O 10.1007/s00044-009-9205-9
10168097 173060 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 587 11 1 9 5.7 CCCCc1nc2ccn(Cc3ccccc3C(=O)OCC)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
CHEMBL45195 173060 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity against AT1 receptor in the presence of 0.01% BSABinding affinity against AT1 receptor in the presence of 0.01% BSA
ChEMBL 587 11 1 9 5.7 CCCCc1nc2ccn(Cc3ccccc3C(=O)OCC)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
10765180 10243 None 0 Bovine Binding pIC50 = 8.3 8.3 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 432 7 3 7 3.3 CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
CHEMBL116094 10243 None 0 Bovine Binding pIC50 = 8.3 8.3 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 432 7 3 7 3.3 CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
10004112 25528 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm9504722
CHEMBL135089 25528 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm9504722
44277489 100411 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccncc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL29020 100411 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccncc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
1610 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
3941 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
3961 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
590 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
CHEMBL191 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
DB00678 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
10439612 161853 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 688 10 1 7 6.8 O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1 10.1021/jm00043a020
CHEMBL414816 161853 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 688 10 1 7 6.8 O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1 10.1021/jm00043a020
10439172 207481 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 644 13 2 8 5.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 10.1021/jm00043a020
CHEMBL94355 207481 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 644 13 2 8 5.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 10.1021/jm00043a020
14956758 106529 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 509 9 1 9 4.1 CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL314042 106529 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 509 9 1 9 4.1 CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
9931685 206082 None 0 Rat Binding pIC50 = 8.3 8.3 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 415 10 1 6 4.9 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1021/jm031100t
CHEMBL85595 206082 None 0 Rat Binding pIC50 = 8.3 8.3 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 415 10 1 6 4.9 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1021/jm031100t
9931685 206082 None 0 Human Binding pIC50 = 8.3 8.3 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 415 10 1 6 4.9 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1016/j.bmc.2010.10.043
CHEMBL85595 206082 None 0 Human Binding pIC50 = 8.3 8.3 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 415 10 1 6 4.9 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1016/j.bmc.2010.10.043
44379335 120219 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 574 10 2 6 6.0 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL352137 120219 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 574 10 2 6 6.0 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1016/S0960-894X(01)81125-2
44379348 164919 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 558 10 1 7 4.7 CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL422374 164919 None 0 Rabbit Binding pIC50 = 8.3 8.3 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 558 10 1 7 4.7 CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
10160805 204062 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 445 11 1 7 4.5 CCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O 10.1021/jm00067a015
CHEMBL70029 204062 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 445 11 1 7 4.5 CCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O 10.1021/jm00067a015
1610 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.07.040
3941 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.07.040
3961 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.07.040
590 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.07.040
CHEMBL191 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.07.040
DB00678 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.07.040
1610 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.12.044
3941 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.12.044
3961 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.12.044
590 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.12.044
CHEMBL191 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.12.044
DB00678 2345 None 95 Human Binding pIC50 = 8.3 8.3 1 4
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.12.044
14956769 107114 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 499 9 1 7 5.3 CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL316052 107114 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 499 9 1 7 5.3 CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44277443 100296 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 583 10 0 8 6.0 CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL28918 100296 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 583 10 0 8 6.0 CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
44310609 203751 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneIn vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 409 5 1 6 4.3 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81150-1
CHEMBL67919 203751 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneIn vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 409 5 1 6 4.3 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81150-1
10008962 119271 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 615 10 2 8 5.4 CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL343719 119271 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 615 10 2 8 5.4 CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10369701 16293 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 529 12 0 7 5.1 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccn2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL122494 16293 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 529 12 0 7 5.1 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccn2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
14956762 98828 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 519 8 1 7 5.6 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL278741 98828 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 519 8 1 7 5.6 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
14956762 98828 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 519 8 1 7 5.6 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL278741 98828 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
ChEMBL 519 8 1 7 5.6 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81132-X
44377123 119973 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 481 10 2 6 3.9 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349856 119973 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 481 10 2 6 3.9 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
10100723 207446 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 646 9 1 7 6.1 CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL94176 207446 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 646 9 1 7 6.1 CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
44315282 96622 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
CHEMBL263452 96622 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
10008962 119271 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 615 10 2 8 5.4 CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343719 119271 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 615 10 2 8 5.4 CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44379217 58147 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 608 10 2 6 7.1 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL167929 58147 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 608 10 2 6 7.1 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
10416957 111497 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 7 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 10.1021/jm00043a020
CHEMBL327791 111497 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 7 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 10.1021/jm00043a020
10372810 106200 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL313868 106200 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.In vitro inhibitory concentration against AT1 receptor from human adrenal tissues.
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
135723852 139138 None 0 Rat Binding pIC50 = 8.2 8.2 - 1
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 438 8 2 6 4.4 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmc.2016.03.028
CHEMBL3787050 139138 None 0 Rat Binding pIC50 = 8.2 8.2 - 1
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 438 8 2 6 4.4 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmc.2016.03.028
44274745 91787 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 633 8 3 8 6.3 CC(=O)Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(00)80335-2
CHEMBL24111 91787 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 633 8 3 8 6.3 CC(=O)Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(00)80335-2
10370801 48427 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 570 12 2 9 4.4 CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-011-9756-4
CHEMBL155554 48427 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 570 12 2 9 4.4 CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-011-9756-4
127035082 136509 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736262 136509 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
1610 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
3941 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
3961 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
590 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
CHEMBL191 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
DB00678 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
9984390 119539 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 527 11 1 8 4.8 CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL345826 119539 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 527 11 1 8 4.8 CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
1610 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
3941 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
3961 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
590 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
CHEMBL191 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
DB00678 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
9888820 9965 None 36 Bovine Binding pIC50 = 7.3 7.3 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 428 8 2 6 4.5 C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1021/jm950450f
CHEMBL114752 9965 None 36 Bovine Binding pIC50 = 7.3 7.3 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 428 8 2 6 4.5 C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1021/jm950450f
44376992 57118 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 422 8 1 7 4.1 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL164552 57118 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 422 8 1 7 4.1 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 10.1016/S0960-894X(01)81124-0
9953638 85054 None 0 Guinea pig Binding pIC50 = 7.3 7.3 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 415 6 1 7 3.9 COC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C 10.1021/jm00061a016
CHEMBL22426 85054 None 0 Guinea pig Binding pIC50 = 7.3 7.3 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 415 6 1 7 3.9 COC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C 10.1021/jm00061a016
9887844 163198 None 4 Guinea pig Binding pIC50 = 7.3 7.3 - 1
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 411 6 1 5 4.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1021/jm00061a016
CHEMBL418226 163198 None 4 Guinea pig Binding pIC50 = 7.3 7.3 - 1
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 411 6 1 5 4.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1021/jm00061a016
14956802 206313 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 515 9 1 7 5.5 CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL87184 206313 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 515 9 1 7 5.5 CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
19385729 50877 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 471 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 10.1016/0960-894X(95)00185-V
CHEMBL15774 50877 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 471 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 10.1016/0960-894X(95)00185-V
15356434 101724 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 590 13 1 8 5.7 CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 10.1021/jm00064a007
CHEMBL299557 101724 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 590 13 1 8 5.7 CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 10.1021/jm00064a007
9869596 115262 None 0 Bovine Binding pIC50 = 6.3 6.3 - 0
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 476 7 2 8 5.1 CCSc1nc2c(C)sc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81118-5
CHEMBL334838 115262 None 0 Bovine Binding pIC50 = 6.3 6.3 - 0
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 476 7 2 8 5.1 CCSc1nc2c(C)sc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81118-5
44321050 206242 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Displacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranesDisplacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranes
ChEMBL 416 9 1 5 4.5 CCCCN1N=C(CCC)C(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O 10.1016/S0960-894X(01)80290-0
CHEMBL86764 206242 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Displacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranesDisplacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, type 1 of rat uterine membranes
ChEMBL 416 9 1 5 4.5 CCCCN1N=C(CCC)C(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O 10.1016/S0960-894X(01)80290-0
15144942 116999 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 422 9 1 3 5.9 CCCCc1ncc(/C=C(\Cc2ccccc2C)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
CHEMBL338813 116999 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 422 9 1 3 5.9 CCCCc1ncc(/C=C(\Cc2ccccc2C)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
71653009 89153 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 575 12 3 4 6.4 CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2337685 89153 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 575 12 3 4 6.4 CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2366019 89153 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 575 12 3 4 6.4 CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.12.044
127035557 136429 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 587 10 2 7 6.9 CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735558 136429 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 587 10 2 7 6.9 CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
44306646 203012 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 504 7 1 6 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)F)cc1 10.1016/S0960-894X(01)81148-3
CHEMBL63280 203012 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 504 7 1 6 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)F)cc1 10.1016/S0960-894X(01)81148-3
10646584 10255 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 436 9 3 5 4.6 CCCc1nc(C(C)(O)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL116102 10255 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 436 9 3 5 4.6 CCCc1nc(C(C)(O)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
22850667 200798 None 0 Rabbit Binding pIC50 = 5.3 5.3 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 542 11 1 3 6.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL60071 200798 None 0 Rabbit Binding pIC50 = 5.3 5.3 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 542 11 1 3 6.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10050519 98507 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 472 10 1 7 5.3 CCCCc1nc(CCCC)n(Cc2ccc(-n3c(Cl)cc(Cl)c3-c3nn[nH]n3)cc2)n1 10.1021/jm00053a013
CHEMBL276150 98507 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 472 10 1 7 5.3 CCCCc1nc(CCCC)n(Cc2ccc(-n3c(Cl)cc(Cl)c3-c3nn[nH]n3)cc2)n1 10.1021/jm00053a013
11477098 206222 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 477 5 1 8 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c3nnnn3c3ccccc23)cc1 10.1021/jm031100t
CHEMBL86655 206222 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 477 5 1 8 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c3nnnn3c3ccccc23)cc1 10.1021/jm031100t
19422629 98397 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 460 9 1 3 6.7 CCCCC1=NC(CC)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL275437 98397 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 460 9 1 3 6.7 CCCCC1=NC(CC)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
57380213 70525 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 517 9 2 4 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947128 70525 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 517 9 2 4 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
44305654 100780 None 0 Bovine Binding pIC50 = 6.3 6.3 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 502 8 1 8 4.8 CCCCc1cc(=O)n2nc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL293001 100780 None 0 Bovine Binding pIC50 = 6.3 6.3 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 502 8 1 8 4.8 CCCCc1cc(=O)n2nc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
10071111 119639 None 0 Rabbit Binding pIC50 = 5.3 5.3 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 426 9 2 7 3.5 CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL346742 119639 None 0 Rabbit Binding pIC50 = 5.3 5.3 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 426 9 2 7 3.5 CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44341786 165300 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 424 5 1 3 5.2 O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2c2ccccc2)cc1 10.1021/jm00074a018
CHEMBL423325 165300 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 424 5 1 3 5.2 O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2c2ccccc2)cc1 10.1021/jm00074a018
10071111 119639 None 0 Rabbit Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 426 9 2 7 3.5 CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL346742 119639 None 0 Rabbit Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 426 9 2 7 3.5 CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
24827772 95786 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 439 8 1 7 4.3 CCCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL258685 95786 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 439 8 1 7 4.3 CCCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
44297144 168015 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 617 8 1 9 5.9 CCCCc1nc2ccc([C@H]3OC[C@H]4[C@@H]3ON3[C@@H]4CCC3(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL432128 168015 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 617 8 1 9 5.9 CCCCc1nc2ccc([C@H]3OC[C@H]4[C@@H]3ON3[C@@H]4CCC3(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
44288321 155197 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 418 7 1 3 5.7 CCCCC1=NC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81139-2
CHEMBL40250 155197 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 418 7 1 3 5.7 CCCCC1=NC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81139-2
127026042 137255 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 620 11 3 9 3.8 CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3751986 137255 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 620 11 3 9 3.8 CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
127036867 137380 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 614 11 3 8 5.7 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753134 137380 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 614 11 3 8 5.7 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
15287884 155239 None 0 Rabbit Binding pIC50 = 6.3 6.3 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 449 8 1 5 5.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccc(Cl)cc2)cc1 10.1016/0960-894X(94)00476-V
CHEMBL40273 155239 None 0 Rabbit Binding pIC50 = 6.3 6.3 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 449 8 1 5 5.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccc(Cl)cc2)cc1 10.1016/0960-894X(94)00476-V
15171420 206687 None 0 Guinea pig Binding pIC50 = 7.3 7.3 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 425 6 1 5 5.3 CCc1cc(OCc2ccc(-c3ccc(C)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
CHEMBL89614 206687 None 0 Guinea pig Binding pIC50 = 7.3 7.3 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 425 6 1 5 5.3 CCc1cc(OCc2ccc(-c3ccc(C)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
44352199 22003 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 423 7 1 6 5.0 CCCCc1nc2c(C)cncc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81118-5
CHEMBL132109 22003 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
Concentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortexConcentration required to inhibit [125I]AII binding to Angiotensin II receptor from membrane fractions of bovine adrenal cortex
ChEMBL 423 7 1 6 5.0 CCCCc1nc2c(C)cncc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81118-5
1610 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a033
3941 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a033
3961 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a033
590 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a033
CHEMBL191 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a033
DB00678 2345 None 95 Rabbit Binding pIC50 = 7.3 7.3 -1 4
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a033
14950504 85488 None 0 Guinea pig Binding pIC50 = 7.3 7.3 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 443 8 1 7 4.6 CCCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC 10.1021/jm00061a016
CHEMBL22692 85488 None 0 Guinea pig Binding pIC50 = 7.3 7.3 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 443 8 1 7 4.6 CCCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC 10.1021/jm00061a016
10052319 163333 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 518 12 1 7 4.4 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]cn2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL419058 163333 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 518 12 1 7 4.4 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]cn2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
9807638 187144 None 0 Bovine Binding pIC50 = 6.3 6.3 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 471 6 1 6 4.7 CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80474-6
CHEMBL49192 187144 None 0 Bovine Binding pIC50 = 6.3 6.3 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 471 6 1 6 4.7 CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80474-6
11743916 119460 None 0 Rabbit Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 439 10 1 7 4.3 CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL345127 119460 None 0 Rabbit Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 439 10 1 7 4.3 CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
19792121 189437 None 0 Bovine Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 493 9 2 6 5.4 CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL51340 189437 None 0 Bovine Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 493 9 2 6 5.4 CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
10363552 20613 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 399 7 2 4 5.4 CCCCc1nc2ccc(N)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL130828 20613 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 399 7 2 4 5.4 CCCCc1nc2ccc(N)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
15699068 5362 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 400 7 2 6 3.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(c1nnn[nH]1)C2 10.1021/jm00114a021
CHEMBL106934 5362 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 400 7 2 6 3.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(c1nnn[nH]1)C2 10.1021/jm00114a021
44303884 202831 None 0 Rabbit Binding pIC50 = 5.3 5.3 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62422 202831 None 0 Rabbit Binding pIC50 = 5.3 5.3 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44459611 100089 None 0 Bovine Binding pIC50 = 4.3 4.3 - 0
Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortexConcentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortex
ChEMBL 568 7 2 7 5.9 COc1ccc(-c2nc3cc(C4=NN(Cc5ccc(-c6ccccc6-c6nn[nH]n6)cc5)C(=O)CC4C)ccc3[nH]2)cc1 10.1016/S0960-894X(01)80348-6
CHEMBL287374 100089 None 0 Bovine Binding pIC50 = 4.3 4.3 - 0
Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortexConcentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortex
ChEMBL 568 7 2 7 5.9 COc1ccc(-c2nc3cc(C4=NN(Cc5ccc(-c6ccccc6-c6nn[nH]n6)cc5)C(=O)CC4C)ccc3[nH]2)cc1 10.1016/S0960-894X(01)80348-6
19792121 189437 None 0 Bovine Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 493 9 2 6 5.4 CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL51340 189437 None 0 Bovine Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 493 9 2 6 5.4 CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
127036868 137361 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 614 11 3 8 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753007 137361 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 614 11 3 8 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
10001717 48254 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 412 7 1 7 4.1 CCCCc1nn2cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL155305 48254 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 412 7 1 7 4.1 CCCCc1nn2cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
9985840 120021 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 426 8 1 7 4.3 CCCCc1nn2cc(CC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL350241 120021 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 426 8 1 7 4.3 CCCCc1nn2cc(CC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
9930953 102800 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 402 6 1 7 2.4 CCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL305350 102800 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 402 6 1 7 2.4 CCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
3025727 184078 None 10 Bovine Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]-angiotensin 2 from angiotensin AT1 receptor in bovine adrenal cortical membranesDisplacement of [125I]-angiotensin 2 from angiotensin AT1 receptor in bovine adrenal cortical membranes
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL48242 184078 None 10 Bovine Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]-angiotensin 2 from angiotensin AT1 receptor in bovine adrenal cortical membranesDisplacement of [125I]-angiotensin 2 from angiotensin AT1 receptor in bovine adrenal cortical membranes
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
3025727 184078 None 10 Bovine Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL48242 184078 None 10 Bovine Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
44358531 119359 None 0 Rabbit Binding pIC50 = 6.3 6.3 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 636 6 3 8 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3cc(Cl)c(S(N)(=O)=O)cc3S(=O)(=O)N2)cc1 10.1016/S0960-894X(01)81119-7
CHEMBL344388 119359 None 0 Rabbit Binding pIC50 = 6.3 6.3 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 636 6 3 8 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3cc(Cl)c(S(N)(=O)=O)cc3S(=O)(=O)N2)cc1 10.1016/S0960-894X(01)81119-7
3025727 184078 None 10 Bovine Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL48242 184078 None 10 Bovine Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
3025727 184078 None 10 Bovine Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL48242 184078 None 10 Bovine Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
44459759 99682 None 0 Bovine Binding pIC50 = 5.3 5.3 - 0
Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortexConcentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortex
ChEMBL 568 7 2 8 5.5 COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(01)80348-6
CHEMBL284546 99682 None 0 Bovine Binding pIC50 = 5.3 5.3 - 0
Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortexConcentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortex
ChEMBL 568 7 2 8 5.5 COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(01)80348-6
15662012 189327 None 0 Bovine Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL51246 189327 None 0 Bovine Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
15699052 109773 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 396 7 2 6 3.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc2cccc(-c3nn[nH]n3)c2c1 10.1021/jm00114a021
CHEMBL323179 109773 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 396 7 2 6 3.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc2cccc(-c3nn[nH]n3)c2c1 10.1021/jm00114a021
44291477 101344 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 406 9 1 3 5.5 CCCCC1=NC(CC)(CC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL296883 101344 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 406 9 1 3 5.5 CCCCC1=NC(CC)(CC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
9888865 57495 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Binding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assayBinding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assay
ChEMBL 429 6 1 6 4.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 10.1016/S0960-894X(01)80193-1
CHEMBL165974 57495 None 0 Rabbit Binding pIC50 = 7.3 7.3 - 0
Binding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assayBinding affinity to Angiotensin II receptor, type 1 in rabbit aorta binding assay
ChEMBL 429 6 1 6 4.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 10.1016/S0960-894X(01)80193-1
127035084 136381 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 707 13 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735151 136381 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 707 13 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44291477 101344 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 406 9 1 3 5.5 CCCCC1=NC(CC)(CC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL296883 101344 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 406 9 1 3 5.5 CCCCC1=NC(CC)(CC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
18942290 193614 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 558 8 1 8 5.6 CCCCc1nc2ccc(C3=NN4CCCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL52700 193614 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 558 8 1 8 5.6 CCCCc1nc2ccc(C3=NN4CCCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
15654747 203830 None 0 Bovine Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 466 9 2 6 5.4 CCCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL68516 203830 None 0 Bovine Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 466 9 2 6 5.4 CCCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
15662012 189327 None 0 Bovine Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL51246 189327 None 0 Bovine Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
76315365 84946 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 535 11 3 8 4.0 CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237580 84946 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 535 11 3 8 4.0 CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
10078057 50632 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 492 10 2 7 4.4 CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL157512 50632 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 492 10 2 7 4.4 CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
44358303 30874 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 520 6 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2N2N=C(c3ccccc3)N[S+]2[O-])cc1 10.1016/S0960-894X(01)81119-7
CHEMBL139739 30874 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 520 6 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2N2N=C(c3ccccc3)N[S+]2[O-])cc1 10.1016/S0960-894X(01)81119-7
15287887 145190 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 460 9 1 7 4.9 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2[N+](=O)[O-])cc1 10.1016/0960-894X(94)00476-V
CHEMBL39124 145190 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 460 9 1 7 4.9 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2[N+](=O)[O-])cc1 10.1016/0960-894X(94)00476-V
127034920 136529 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 547 10 2 5 6.7 CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3736451 136529 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 547 10 2 5 6.7 CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
46910582 70351 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945009 70351 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
127036107 136514 None 0 Human Binding pIC50 = 7.2 7.2 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 561 11 2 5 6.8 CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3736319 136514 None 0 Human Binding pIC50 = 7.2 7.2 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 561 11 2 5 6.8 CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
9940350 204756 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
CHEMBL74573 204756 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
10072002 115241 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 441 8 2 4 5.8 CCCCc1nc2c(NC(C)=O)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL334741 115241 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 441 8 2 4 5.8 CCCCc1nc2c(NC(C)=O)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
11328411 106165 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 450 6 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(CC(=O)O)cnc3ccccc23)cc1 10.1021/jm031100t
CHEMBL313718 106165 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 450 6 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(CC(=O)O)cnc3ccccc23)cc1 10.1021/jm031100t
10786794 162890 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 394 8 3 5 3.4 CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL417366 162890 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 394 8 3 5 3.4 CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
10786794 162890 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 394 8 3 5 3.4 CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
CHEMBL417366 162890 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 394 8 3 5 3.4 CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
15654757 102225 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 494 7 2 7 4.6 O=C(O)c1cccc2nc(OCC(F)(F)F)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 10.1021/jm00067a016
CHEMBL302973 102225 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 494 7 2 7 4.6 O=C(O)c1cccc2nc(OCC(F)(F)F)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 10.1021/jm00067a016
15654752 102252 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 454 8 2 7 3.8 COCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL303170 102252 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 454 8 2 7 3.8 COCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
44295010 187242 None 0 Bovine Binding pIC50 = 5.2 5.2 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 445 6 1 6 4.1 CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80474-6
CHEMBL49262 187242 None 0 Bovine Binding pIC50 = 5.2 5.2 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 445 6 1 6 4.1 CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80474-6
54768877 65118 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 535 9 1 8 5.2 CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(CC)cc1 10.1016/j.ejmech.2011.05.056
CHEMBL1824003 65118 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 535 9 1 8 5.2 CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(CC)cc1 10.1016/j.ejmech.2011.05.056
14951089 102941 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 583 12 1 8 6.0 CCCCc1nn(C(Cc2ccccc2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL306328 102941 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 583 12 1 8 6.0 CCCCc1nn(C(Cc2ccccc2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
44341597 9957 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 505 9 2 5 3.8 CCCCC1=NC2(CCN(C(=O)CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL114710 9957 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 505 9 2 5 3.8 CCCCC1=NC2(CCN(C(=O)CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
44315350 105216 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL311484 105216 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
10275744 206116 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 451 8 1 7 4.3 CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL85876 206116 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 451 8 1 7 4.3 CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
44293656 188011 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 514 13 2 7 5.4 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](CCCC)n2cccc2C(=O)OC)cc1 10.1021/jm00064a007
CHEMBL49748 188011 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 514 13 2 7 5.4 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](CCCC)n2cccc2C(=O)OC)cc1 10.1021/jm00064a007
15780089 99807 None 0 Rabbit Binding pIC50 = 6.2 6.2 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 603 8 1 7 6.4 Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL285432 99807 None 0 Rabbit Binding pIC50 = 6.2 6.2 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 603 8 1 7 6.4 Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44303887 203319 None 0 Rabbit Binding pIC50 = 4.2 4.2 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64861 203319 None 0 Rabbit Binding pIC50 = 4.2 4.2 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
71521194 86810 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 423 4 2 6 3.7 CCc1nc2cc[nH]c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322177 86810 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 423 4 2 6 3.7 CCc1nc2cc[nH]c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
24828038 159453 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 424 7 1 6 4.5 CCCCn1c(=O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL410125 159453 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 424 7 1 6 4.5 CCCCn1c(=O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
19087866 98934 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 436 7 1 6 4.6 CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL279515 98934 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 436 7 1 6 4.6 CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
14956801 206108 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 555 9 1 7 5.0 CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL85765 206108 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 555 9 1 7 5.0 CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
60165459 105249 None 7 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 566 10 1 7 7.7 CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)nc2ccccc21 10.1016/j.bmcl.2014.01.004
CHEMBL3115247 105249 None 7 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 566 10 1 7 7.7 CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)nc2ccccc21 10.1016/j.bmcl.2014.01.004
44277594 101801 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 619 8 1 9 5.9 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL30015 101801 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 619 8 1 9 5.9 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
44306651 100538 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 533 3 1 4 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(I)c1 10.1016/S0960-894X(01)81148-3
CHEMBL291358 100538 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 533 3 1 4 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(I)c1 10.1016/S0960-894X(01)81148-3
3081289 10022 None 11 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 416 8 2 6 4.0 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL115021 10022 None 11 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 416 8 2 6 4.0 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
6918269 98468 None 11 Human Binding pIC50 = 8.2 8.2 776 2
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL275875 98468 None 11 Human Binding pIC50 = 8.2 8.2 776 2
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL295959 98468 None 11 Human Binding pIC50 = 8.2 8.2 776 2
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
19771826 206623 None 0 Guinea pig Binding pIC50 = 8.2 8.2 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparation
ChEMBL 453 7 1 6 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(C)=O)c2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
CHEMBL89143 206623 None 0 Guinea pig Binding pIC50 = 8.2 8.2 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparation
ChEMBL 453 7 1 6 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(C)=O)c2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
9895957 10671 None 18 Human Binding pIC50 = 8.2 8.2 -5 3
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1039/C4MD00499J
CHEMBL11706 10671 None 18 Human Binding pIC50 = 8.2 8.2 -5 3
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1039/C4MD00499J
1610 2345 None 95 Human Binding pIC50 = 8.2 8.2 1 4
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.07.040
3941 2345 None 95 Human Binding pIC50 = 8.2 8.2 1 4
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.07.040
3961 2345 None 95 Human Binding pIC50 = 8.2 8.2 1 4
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.07.040
590 2345 None 95 Human Binding pIC50 = 8.2 8.2 1 4
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.07.040
CHEMBL191 2345 None 95 Human Binding pIC50 = 8.2 8.2 1 4
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.07.040
DB00678 2345 None 95 Human Binding pIC50 = 8.2 8.2 1 4
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.07.040
108185 1612 None 78 Rabbit Binding pIC50 = 8.2 8.2 - 1
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00057a009
586 1612 None 78 Rabbit Binding pIC50 = 8.2 8.2 - 1
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00057a009
CHEMBL907 1612 None 78 Rabbit Binding pIC50 = 8.2 8.2 - 1
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00057a009
15236334 165598 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 520 6 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3)[S+]([O-])N2)cc1 10.1016/S0960-894X(01)81119-7
CHEMBL424289 165598 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 520 6 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3)[S+]([O-])N2)cc1 10.1016/S0960-894X(01)81119-7
108185 1612 None 78 Rabbit Binding pIC50 = 8.2 8.2 - 1
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00050a002
586 1612 None 78 Rabbit Binding pIC50 = 8.2 8.2 - 1
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00050a002
CHEMBL907 1612 None 78 Rabbit Binding pIC50 = 8.2 8.2 - 1
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00050a002
10394727 103060 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 672 15 2 9 5.4 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL307321 103060 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 672 15 2 9 5.4 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
44311650 103199 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 674 14 2 10 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL308361 103199 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 674 14 2 10 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
44311607 204181 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 517 9 3 8 4.5 CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70770 204181 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 517 9 3 8 4.5 CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222103 204537 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 678 12 2 9 5.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL72819 204537 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 678 12 2 9 5.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(00)80076-1
3081289 10022 None 11 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 416 8 2 6 4.0 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL115021 10022 None 11 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 416 8 2 6 4.0 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81124-0
44376760 165392 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 532 11 3 6 4.7 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL423801 165392 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 532 11 3 6 4.7 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
14950498 99022 None 0 Guinea pig Binding pIC50 = 8.2 8.2 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 461 7 1 6 5.4 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 10.1021/jm00061a016
CHEMBL280189 99022 None 0 Guinea pig Binding pIC50 = 8.2 8.2 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 461 7 1 6 5.4 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 10.1021/jm00061a016
14950505 99155 None 0 Guinea pig Binding pIC50 = 8.2 8.2 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 433 6 1 5 5.8 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccccc2)c(C)n1 10.1021/jm00061a016
CHEMBL281192 99155 None 0 Guinea pig Binding pIC50 = 8.2 8.2 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 433 6 1 5 5.8 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccccc2)c(C)n1 10.1021/jm00061a016
44341922 10415 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 434 10 2 5 3.6 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(N)=O)C(C)C 10.1016/S0960-894X(01)81117-3
CHEMBL116298 10415 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 434 10 2 5 3.6 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(N)=O)C(C)C 10.1016/S0960-894X(01)81117-3
9888876 48988 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 10.1016/0960-894X(95)00185-V
CHEMBL15606 48988 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 10.1016/0960-894X(95)00185-V
10437754 119707 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 558 12 2 8 5.6 CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL347404 119707 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 558 12 2 8 5.6 CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
76319527 85402 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 514 11 0 6 5.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2c2ccccc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL2263317 85402 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 514 11 0 6 5.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2c2ccccc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
10437754 119707 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 558 12 2 8 5.6 CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL347404 119707 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 558 12 2 8 5.6 CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
10394859 17427 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL125760 17427 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
127029976 139215 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786145 139215 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787767 139215 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
44376781 56270 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 517 10 2 6 4.8 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL162859 56270 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 517 10 2 6 4.8 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
44305663 100997 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 412 6 1 8 2.7 CCCc1cc2ncnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL294358 100997 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 412 6 1 8 2.7 CCCc1cc2ncnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
127034922 136361 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 571 10 2 7 6.2 CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3734891 136361 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 571 10 2 7 6.2 CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
44274823 99073 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 551 10 2 8 5.8 CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL280526 99073 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 551 10 2 8 5.8 CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
10076191 118449 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 548 13 0 6 5.8 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC(F)(F)F)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL341151 118449 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 548 13 0 6 5.8 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC(F)(F)F)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
44277874 99552 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 629 11 0 9 6.9 CCCCCN(C(=O)c1ccc(SC)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL28359 99552 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 629 11 0 9 6.9 CCCCCN(C(=O)c1ccc(SC)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
44459903 99500 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 464 8 1 6 5.3 CCCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL283292 99500 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 464 8 1 6 5.3 CCCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
9931685 206082 None 0 Rat Binding pIC50 = 8.2 8.2 - 1
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 415 10 1 6 4.9 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1021/jm00053a013
CHEMBL85595 206082 None 0 Rat Binding pIC50 = 8.2 8.2 - 1
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 415 10 1 6 4.9 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1021/jm00053a013
44277481 101569 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 647 9 1 9 5.8 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(C(=O)O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL29853 101569 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 647 9 1 9 5.8 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(C(=O)O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
9932483 207841 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 431 10 1 7 4.1 CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 10.1016/j.bmc.2010.10.043
CHEMBL9642 207841 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 431 10 1 7 4.1 CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 10.1016/j.bmc.2010.10.043
44358381 29357 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 634 6 2 8 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3cc(S(N)(=O)=O)c(Cl)cc3N2)cc1 10.1016/S0960-894X(01)81119-7
CHEMBL138358 29357 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
ChEMBL 634 6 2 8 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3cc(S(N)(=O)=O)c(Cl)cc3N2)cc1 10.1016/S0960-894X(01)81119-7
19029589 118766 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 431 6 1 7 3.2 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2CC2)s1 10.1016/S0960-894X(96)00250-8
CHEMBL34190 118766 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 431 6 1 7 3.2 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2CC2)s1 10.1016/S0960-894X(96)00250-8
76311802 84961 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 569 12 2 10 5.3 CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237595 84961 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 569 12 2 10 5.3 CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
10048770 118392 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 438 10 2 5 3.9 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
CHEMBL341070 118392 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 438 10 2 5 3.9 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 10.1007/s00044-009-9205-9
14956740 205806 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL83248 205806 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
9984360 119618 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 526 11 1 9 5.7 CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL346542 119618 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 526 11 1 9 5.7 CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
44277574 101899 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL30086 101899 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
1610 2345 None 95 Rat Binding pIC50 = 8.2 8.2 -1 4
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm031100t
3941 2345 None 95 Rat Binding pIC50 = 8.2 8.2 -1 4
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm031100t
3961 2345 None 95 Rat Binding pIC50 = 8.2 8.2 -1 4
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm031100t
590 2345 None 95 Rat Binding pIC50 = 8.2 8.2 -1 4
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm031100t
CHEMBL191 2345 None 95 Rat Binding pIC50 = 8.2 8.2 -1 4
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm031100t
DB00678 2345 None 95 Rat Binding pIC50 = 8.2 8.2 -1 4
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm031100t
1610 2345 None 95 Rat Binding pIC50 = 8.2 8.2 -1 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
3941 2345 None 95 Rat Binding pIC50 = 8.2 8.2 -1 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
3961 2345 None 95 Rat Binding pIC50 = 8.2 8.2 -1 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
590 2345 None 95 Rat Binding pIC50 = 8.2 8.2 -1 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
CHEMBL191 2345 None 95 Rat Binding pIC50 = 8.2 8.2 -1 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
DB00678 2345 None 95 Rat Binding pIC50 = 8.2 8.2 -1 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
10053499 48789 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 558 11 2 8 6.0 CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-011-9756-4
CHEMBL155877 48789 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 558 11 2 8 6.0 CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-011-9756-4
10482258 119673 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 534 11 2 6 6.6 CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL347135 119673 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 534 11 2 6 6.6 CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
9888159 106964 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 416 10 1 7 4.3 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cn2)n1 10.1021/jm031100t
CHEMBL315022 106964 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 416 10 1 7 4.3 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cn2)n1 10.1021/jm031100t
44348259 16030 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 575 12 1 5 8.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 10.1021/jm00075a033
CHEMBL122367 16030 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
ChEMBL 575 12 1 5 8.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 10.1021/jm00075a033
10053499 48789 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 558 11 2 8 6.0 CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL155877 48789 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 558 11 2 8 6.0 CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
10482258 119673 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 534 11 2 6 6.6 CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL347135 119673 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 534 11 2 6 6.6 CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
71520500 86808 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 541 6 1 7 5.8 CCc1nc2c(C)cn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322175 86808 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 541 6 1 7 5.8 CCc1nc2c(C)cn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
53309274 63774 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 449 5 1 6 5.2 CCc1cc(C)c2nc(CC)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 10.1021/jm200409s
CHEMBL1801738 63774 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 449 5 1 6 5.2 CCc1cc(C)c2nc(CC)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 10.1021/jm200409s
44277442 100295 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 583 10 0 8 6.1 CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL28917 100295 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 583 10 0 8 6.1 CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
132706 1674 None 24 Rat Binding pIC50 = 8.2 8.2 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1021/jm031100t
6896 1674 None 24 Rat Binding pIC50 = 8.2 8.2 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1021/jm031100t
CHEMBL315021 1674 None 24 Rat Binding pIC50 = 8.2 8.2 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1021/jm031100t
DB01342 1674 None 24 Rat Binding pIC50 = 8.2 8.2 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1021/jm031100t
10344235 206158 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 460 5 1 7 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 10.1021/jm031100t
CHEMBL86247 206158 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 460 5 1 7 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 10.1021/jm031100t
132706 1674 None 24 Human Binding pIC50 = 8.2 8.2 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1016/j.bmc.2010.10.043
6896 1674 None 24 Human Binding pIC50 = 8.2 8.2 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1016/j.bmc.2010.10.043
CHEMBL315021 1674 None 24 Human Binding pIC50 = 8.2 8.2 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1016/j.bmc.2010.10.043
DB01342 1674 None 24 Human Binding pIC50 = 8.2 8.2 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1016/j.bmc.2010.10.043
10344235 206158 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 460 5 1 7 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 10.1021/jm7011563
CHEMBL86247 206158 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 460 5 1 7 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 10.1021/jm7011563
15224471 154831 None 0 Bovine Binding pIC50 = 8.2 8.2 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 441 8 2 7 4.1 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL400424 154831 None 0 Bovine Binding pIC50 = 8.2 8.2 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 441 8 2 7 4.1 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
10645687 10170 None 0 Bovine Binding pIC50 = 8.2 8.2 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 418 8 3 7 2.9 CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
CHEMBL115946 10170 None 0 Bovine Binding pIC50 = 8.2 8.2 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 418 8 3 7 2.9 CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
10368143 46757 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 486 10 2 6 5.8 CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL153968 46757 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 486 10 2 6 5.8 CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
10459507 47723 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 525 11 2 7 5.8 CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL154772 47723 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 525 11 2 7 5.8 CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
14956775 203979 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 375 7 2 7 3.2 CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL69508 203979 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 375 7 2 7 3.2 CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
76310610 105248 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 542 10 1 5 8.2 CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5C(=O)O)cc4)c3c2)nc2ccccc21 10.1016/j.bmcl.2014.01.004
CHEMBL3115246 105248 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 542 10 1 5 8.2 CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5C(=O)O)cc4)c3c2)nc2ccccc21 10.1016/j.bmcl.2014.01.004
44293815 184245 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 549 11 2 6 6.4 CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
CHEMBL48363 184245 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 549 11 2 6 6.4 CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
44341824 10014 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 452 7 1 3 5.5 CCCCC1=NC2(Cc3ccccc3C2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL114983 10014 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 452 7 1 3 5.5 CCCCC1=NC2(Cc3ccccc3C2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
19889356 179895 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 410 6 1 7 4.0 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2-c2nn[nH]n2)cc1 10.1021/jm031100t
CHEMBL47459 179895 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 410 6 1 7 4.0 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2-c2nn[nH]n2)cc1 10.1021/jm031100t
44348332 15534 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 485 6 1 6 5.1 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCCC2 10.1016/S0960-894X(01)80914-8
CHEMBL121871 15534 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 485 6 1 6 5.1 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCCC2 10.1016/S0960-894X(01)80914-8
44348323 16456 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 445 7 1 6 4.1 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(C)CC 10.1016/S0960-894X(01)80914-8
CHEMBL123348 16456 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
ChEMBL 445 7 1 6 4.1 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(C)CC 10.1016/S0960-894X(01)80914-8
10368143 46757 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 486 10 2 6 5.8 CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL153968 46757 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 486 10 2 6 5.8 CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
10459507 47723 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 525 11 2 7 5.8 CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL154772 47723 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 525 11 2 7 5.8 CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
19889356 179895 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.
ChEMBL 410 6 1 7 4.0 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80044-X
CHEMBL47459 179895 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.
ChEMBL 410 6 1 7 4.0 CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80044-X
10642523 110464 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 364 7 2 4 3.9 CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL324729 110464 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 364 7 2 4 3.9 CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
9982103 115153 None 0 Guinea pig Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 432 6 1 6 5.1 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C#N)cccc2n1 10.1021/jm00100a007
CHEMBL334431 115153 None 0 Guinea pig Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 432 6 1 6 5.1 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C#N)cccc2n1 10.1021/jm00100a007
44341924 11323 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 489 11 2 5 5.5 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](CC1CCCCC1)C(=O)O 10.1016/S0960-894X(01)81117-3
CHEMBL117941 11323 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 489 11 2 5 5.5 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](CC1CCCCC1)C(=O)O 10.1016/S0960-894X(01)81117-3
11561462 111131 None 61 Human Binding pIC50 = 7.2 7.2 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 449 10 1 6 4.3 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)OC)C(C)C 10.1016/S0960-894X(01)81117-3
CHEMBL326349 111131 None 61 Human Binding pIC50 = 7.2 7.2 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 449 10 1 6 4.3 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)OC)C(C)C 10.1016/S0960-894X(01)81117-3
15287885 161813 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 449 8 1 5 5.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc(Cl)c2)cc1 10.1016/0960-894X(94)00476-V
CHEMBL41440 161813 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 449 8 1 5 5.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc(Cl)c2)cc1 10.1016/0960-894X(94)00476-V
15699054 109483 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 396 7 2 6 3.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc2cc(-c3nn[nH]n3)ccc2c1 10.1021/jm00114a021
CHEMBL322071 109483 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 396 7 2 6 3.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc2cc(-c3nn[nH]n3)ccc2c1 10.1021/jm00114a021
24828034 166428 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 510 8 1 9 3.7 CCCCn1c(=O)c2ccc(N3CCOCC3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL427738 166428 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 510 8 1 9 3.7 CCCCn1c(=O)c2ccc(N3CCOCC3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
19792191 98376 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 9 1 6 5.4 CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL275304 98376 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 9 1 6 5.4 CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
10503729 9683 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 450 9 2 6 4.7 CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL113040 9683 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 450 9 2 6 4.7 CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
11741515 116841 None 0 Guinea pig Binding pIC50 = 6.2 6.2 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 397 7 1 3 6.1 CCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 10.1021/jm00100a007
CHEMBL338048 116841 None 0 Guinea pig Binding pIC50 = 6.2 6.2 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 397 7 1 3 6.1 CCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 10.1021/jm00100a007
21840429 110918 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 393 9 2 5 3.1 CCCCC(=O)N(CC(=O)O)Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81117-3
CHEMBL326140 110918 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 393 9 2 5 3.1 CCCCC(=O)N(CC(=O)O)Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81117-3
44298570 101012 None 0 Bovine Binding pIC50 = 5.2 5.2 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 452 7 1 7 4.2 CCCOc1nc2c(C)cccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
CHEMBL294485 101012 None 0 Bovine Binding pIC50 = 5.2 5.2 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 452 7 1 7 4.2 CCCOc1nc2c(C)cccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
44298809 195511 None 0 Bovine Binding pIC50 = 5.2 5.2 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 452 6 1 7 4.2 Cc1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 10.1016/S0960-894X(01)81144-6
CHEMBL55366 195511 None 0 Bovine Binding pIC50 = 5.2 5.2 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 452 6 1 7 4.2 Cc1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 10.1016/S0960-894X(01)81144-6
19792191 98376 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 9 1 6 5.4 CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL275304 98376 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 9 1 6 5.4 CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
18572337 81155 None 9 Human Binding pIC50 = 4.2 4.2 - 0
Inhibition of AT1 receptorInhibition of AT1 receptor
ChEMBL 419 6 0 9 3.5 O=C(Oc1coc(CSc2ncccn2)cc1=O)c1cc([N+](=O)[O-])ccc1Cl 10.1016/j.bmcl.2012.08.105
CHEMBL2158005 81155 None 9 Human Binding pIC50 = 4.2 4.2 - 0
Inhibition of AT1 receptorInhibition of AT1 receptor
ChEMBL 419 6 0 9 3.5 O=C(Oc1coc(CSc2ncccn2)cc1=O)c1cc([N+](=O)[O-])ccc1Cl 10.1016/j.bmcl.2012.08.105
127035248 136439 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 549 9 2 5 7.0 CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735653 136439 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 549 9 2 5 7.0 CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
9937461 101821 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 551 9 2 9 4.3 CCCCc1nc2ccc([C@@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL300279 101821 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 551 9 2 9 4.3 CCCCc1nc2ccc([C@@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
127035263 136458 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 577 11 2 5 7.8 CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735804 136458 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 577 11 2 5 7.8 CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
44341836 110411 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 470 7 1 3 6.2 CCCCC1=NC2(C(=O)N1Cc1ccc(-c3ccccc3C(=O)O)cc1)C1CC3CC(C1)CC2C3 10.1021/jm00074a018
CHEMBL324452 110411 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 470 7 1 3 6.2 CCCCC1=NC2(C(=O)N1Cc1ccc(-c3ccccc3C(=O)O)cc1)C1CC3CC(C1)CC2C3 10.1021/jm00074a018
15654703 204306 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 439 7 3 7 4.1 CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL71410 204306 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 439 7 3 7 4.1 CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
44305663 100997 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 412 6 1 8 2.7 CCCc1cc2ncnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL294358 100997 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 412 6 1 8 2.7 CCCc1cc2ncnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
19385598 98860 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 457 8 1 6 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 10.1016/0960-894X(95)00185-V
CHEMBL278955 98860 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 457 8 1 6 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 10.1016/0960-894X(95)00185-V
135723843 100955 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 468 8 2 7 5.5 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
CHEMBL294140 100955 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 468 8 2 7 5.5 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
15654753 204225 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 470 8 2 7 4.5 CSCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL70947 204225 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 470 8 2 7 4.5 CSCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
127035393 136389 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 587 10 2 7 6.9 CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735227 136389 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 587 10 2 7 6.9 CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
76315369 84975 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 522 12 2 8 4.7 CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237609 84975 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 522 12 2 8 4.7 CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
10005344 47169 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 479 11 1 7 5.1 CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL154315 47169 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 479 11 1 7 5.1 CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
44320816 206272 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranesInhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranes
ChEMBL 414 10 1 5 5.5 CCCCc1cn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CCCC)n1 10.1016/S0960-894X(01)80290-0
CHEMBL86935 206272 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranesInhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranes
ChEMBL 414 10 1 5 5.5 CCCCc1cn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CCCC)n1 10.1016/S0960-894X(01)80290-0
71521585 86807 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 532 6 1 9 4.8 CCc1nc2ccn(Cc3c(C)noc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322174 86807 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 532 6 1 9 4.8 CCc1nc2ccn(Cc3c(C)noc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
71521505 86833 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 514 6 1 8 4.6 CCc1nc2ccn(Cc3ccccn3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322451 86833 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 514 6 1 8 4.6 CCc1nc2ccn(Cc3ccccn3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
70684421 76632 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
CHEMBL2063980 76632 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
9979266 117291 None 0 Guinea pig Binding pIC50 = 5.2 5.2 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 379 5 1 5 4.7 c1ccc(-c2nn[nH]n2)c(-c2ccc(COc3ccnc4ccccc34)cc2)c1 10.1021/jm00100a007
CHEMBL339592 117291 None 0 Guinea pig Binding pIC50 = 5.2 5.2 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 379 5 1 5 4.7 c1ccc(-c2nn[nH]n2)c(-c2ccc(COc3ccnc4ccccc34)cc2)c1 10.1021/jm00100a007
70684421 76632 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
CHEMBL2063980 76632 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma countingDisplacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting
ChEMBL 422 8 2 6 4.3 CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.07.040
71654380 89155 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 657 12 3 8 6.1 CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2337680 89155 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 657 12 3 8 6.1 CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2366021 89155 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 657 12 3 8 6.1 CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
44315344 105079 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL311386 105079 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
19036230 101752 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 408 9 3 5 3.8 CCCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
CHEMBL299809 101752 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 408 9 3 5 3.8 CCCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
15287883 98208 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 415 8 1 5 4.9 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL274260 98208 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 415 8 1 5 4.9 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
15654760 102190 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 467 9 3 7 4.8 CCCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL302811 102190 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 467 9 3 7 4.8 CCCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
44342002 9947 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 432 7 1 3 5.9 CCCCC1=NC2(CCC(C)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL114656 9947 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 432 7 1 3 5.9 CCCCC1=NC2(CCC(C)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
11352388 105943 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 493 8 2 6 6.4 CCCNc1nc2ccccc2c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1C(=O)O 10.1021/jm031100t
CHEMBL312889 105943 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 493 8 2 6 6.4 CCCNc1nc2ccccc2c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1C(=O)O 10.1021/jm031100t
9983514 19479 None 0 Guinea pig Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 465 7 1 7 5.0 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)OC)ccc2n1 10.1021/jm00100a007
CHEMBL129872 19479 None 0 Guinea pig Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 465 7 1 7 5.0 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)OC)ccc2n1 10.1021/jm00100a007
15654696 103777 None 65 Bovine Binding pIC50 = 7.2 7.2 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 454 7 1 8 4.1 CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL308884 103777 None 65 Bovine Binding pIC50 = 7.2 7.2 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 454 7 1 8 4.1 CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
44341698 159934 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 442 7 0 6 4.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn(C)n2)cc1 10.1021/jm00074a018
CHEMBL410724 159934 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 442 7 0 6 4.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn(C)n2)cc1 10.1021/jm00074a018
44295673 162777 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 428 8 2 4 5.5 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1007/s00044-009-9182-z
CHEMBL417196 162777 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 428 8 2 4 5.5 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1007/s00044-009-9182-z
44295673 162777 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 428 8 2 4 5.5 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1007/s00044-009-9182-z
CHEMBL417196 162777 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 428 8 2 4 5.5 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1007/s00044-009-9182-z
44305289 203275 None 0 Bovine Binding pIC50 = 5.2 5.2 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 416 6 1 7 2.7 CCCc1c(C)c(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL64670 203275 None 0 Bovine Binding pIC50 = 5.2 5.2 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 416 6 1 7 2.7 CCCc1c(C)c(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
18654313 63768 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 435 4 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1[C@@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
CHEMBL1801713 63768 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 435 4 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1[C@@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
15171411 206200 None 0 Guinea pig Binding pIC50 = 7.2 7.2 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 441 7 1 6 5.0 CCc1cc(OCc2ccc(-c3cc(OC)ccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
CHEMBL86495 206200 None 0 Guinea pig Binding pIC50 = 7.2 7.2 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 441 7 1 6 5.0 CCc1cc(OCc2ccc(-c3cc(OC)ccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
71521419 86829 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 531 6 1 7 5.3 CCc1nc2ccn(Cc3cccc(F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322448 86829 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 531 6 1 7 5.3 CCc1nc2ccn(Cc3cccc(F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
127026041 137528 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 605 11 3 8 5.0 CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3754267 137528 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 605 11 3 8 5.0 CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
44293911 188240 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 510 11 2 6 5.9 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2)cc1 10.1021/jm00064a007
CHEMBL49954 188240 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 510 11 2 6 5.9 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2)cc1 10.1021/jm00064a007
127035381 136471 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 573 9 2 7 6.5 CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735940 136471 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 573 9 2 7 6.5 CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
14956800 206148 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 509 10 2 8 4.0 CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL86143 206148 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 509 10 2 8 4.0 CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
22850890 189772 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 577 8 1 10 4.1 CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL51606 189772 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 577 8 1 10 4.1 CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
44294562 189144 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 501 10 1 6 5.7 CCCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(00)80474-6
CHEMBL51078 189144 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 501 10 1 6 5.7 CCCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(00)80474-6
44563175 189091 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortexDisplacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex
ChEMBL 570 7 1 5 8.6 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc(Cl)[nH]2)cc1 10.1016/j.bmc.2008.10.040
CHEMBL510065 189091 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortexDisplacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex
ChEMBL 570 7 1 5 8.6 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc(Cl)[nH]2)cc1 10.1016/j.bmc.2008.10.040
14956746 206192 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL86440 206192 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44270285 99063 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 415 7 1 5 4.7 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL280456 99063 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 415 7 1 5 4.7 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
127026040 137477 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 591 11 3 8 4.6 CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753888 137477 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 591 11 3 8 4.6 CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
44298833 198507 None 0 Bovine Binding pIC50 = 4.2 4.2 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 482 7 2 8 3.6 CC(C)Oc1nc2ccc(C(=O)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
CHEMBL57781 198507 None 0 Bovine Binding pIC50 = 4.2 4.2 - 0
Binding affinity for angiotensin II receptor of bovine adrenal cortexBinding affinity for angiotensin II receptor of bovine adrenal cortex
ChEMBL 482 7 2 8 3.6 CC(C)Oc1nc2ccc(C(=O)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81144-6
127035249 136519 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 573 9 2 7 6.5 CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3736346 136519 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 573 9 2 7 6.5 CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
44274733 99405 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 482 8 1 7 5.4 CCCCc1nc2ccc(SC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL282746 99405 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 482 8 1 7 5.4 CCCCc1nc2ccc(SC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
15171415 106936 None 0 Guinea pig Binding pIC50 = 8.2 8.2 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparation
ChEMBL 445 6 1 5 5.6 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(Cl)c2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
CHEMBL314859 106936 None 0 Guinea pig Binding pIC50 = 8.2 8.2 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparation
ChEMBL 445 6 1 5 5.6 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(Cl)c2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
127035757 136503 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 591 10 1 8 6.2 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736242 136503 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 591 10 1 8 6.2 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
71520501 86809 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 552 6 1 8 5.4 CCc1nc2c(C)cn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322176 86809 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 552 6 1 8 5.4 CCc1nc2c(C)cn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
44376991 120293 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 436 8 1 7 4.3 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL352675 120293 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 436 8 1 7 4.3 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 10.1016/S0960-894X(01)81124-0
10075750 107556 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 532 10 1 7 4.8 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL318891 107556 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 532 10 1 7 4.8 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
9851889 102072 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL302102 102072 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
19010079 84954 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 524 11 2 8 5.4 CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237588 84954 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 524 11 2 8 5.4 CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
10367792 17939 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 478 9 1 7 4.2 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL125958 17939 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 478 9 1 7 4.2 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
9981102 164190 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 448 10 2 7 3.1 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 10.1007/s00044-009-9205-9
CHEMBL421074 164190 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 448 10 2 7 3.1 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 10.1007/s00044-009-9205-9
10096735 119528 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 481 10 1 7 5.8 CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL345717 119528 None 0 Rabbit Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 481 10 1 7 5.8 CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
44277873 98870 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 661 11 0 10 5.5 CCCCCN(C(=O)c1ccc(S(C)(=O)=O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL27903 98870 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 661 11 0 10 5.5 CCCCCN(C(=O)c1ccc(S(C)(=O)=O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
44342039 10291 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 418 7 1 3 5.7 CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL116170 10291 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 418 7 1 3 5.7 CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
19029573 120717 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 405 5 1 7 2.9 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(C)=O)s1 10.1016/S0960-894X(96)00250-8
CHEMBL35475 120717 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 405 5 1 7 2.9 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(C)=O)s1 10.1016/S0960-894X(96)00250-8
44314780 103076 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL307430 103076 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
127034921 136526 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 547 10 2 5 6.7 CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3736440 136526 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 547 10 2 5 6.7 CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
44291781 181556 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 406 8 1 3 5.4 CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL47669 181556 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 406 8 1 3 5.4 CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
1037 1576 None 69 Human Binding pIC50 = 8.1 8.1 - 1
Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA)
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
3940 1576 None 69 Human Binding pIC50 = 8.1 8.1 - 1
Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA)
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
5281037 1576 None 69 Human Binding pIC50 = 8.1 8.1 - 1
Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA)
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
588 1576 None 69 Human Binding pIC50 = 8.1 8.1 - 1
Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA)
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
CHEMBL813 1576 None 69 Human Binding pIC50 = 8.1 8.1 - 1
Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA)
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
DB00876 1576 None 69 Human Binding pIC50 = 8.1 8.1 - 1
Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA)
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1016/S0960-894X(01)81116-1
11757193 51347 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 546 12 2 7 4.9 CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL158133 51347 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 546 12 2 7 4.9 CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
2806 3967 None 110 Human Binding pIC50 = 8.1 8.1 - 1
Displacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassayDisplacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassay
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/acs.jmedchem.1c00123
3937 3967 None 110 Human Binding pIC50 = 8.1 8.1 - 1
Displacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassayDisplacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassay
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/acs.jmedchem.1c00123
593 3967 None 110 Human Binding pIC50 = 8.1 8.1 - 1
Displacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassayDisplacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassay
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/acs.jmedchem.1c00123
60846 3967 None 110 Human Binding pIC50 = 8.1 8.1 - 1
Displacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassayDisplacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassay
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/acs.jmedchem.1c00123
CHEMBL1069 3967 None 110 Human Binding pIC50 = 8.1 8.1 - 1
Displacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassayDisplacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassay
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/acs.jmedchem.1c00123
DB00177 3967 None 110 Human Binding pIC50 = 8.1 8.1 - 1
Displacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassayDisplacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassay
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/acs.jmedchem.1c00123
11757193 51347 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 546 12 2 7 4.9 CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL158133 51347 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 546 12 2 7 4.9 CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
44379269 57166 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 644 12 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL164769 57166 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 644 12 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
44376779 56501 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 496 11 3 6 3.8 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL163485 56501 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 496 11 3 6 3.8 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
44277549 99126 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 594 8 0 10 5.1 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL280988 99126 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 594 8 0 10 5.1 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
44300637 100923 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 600 11 1 7 7.2 CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
CHEMBL293949 100923 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 600 11 1 7 7.2 CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
10436523 119461 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 514 11 2 6 6.2 CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL345139 119461 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 514 11 2 6 6.2 CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
10436523 119461 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 514 11 2 6 6.2 CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL345139 119461 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 514 11 2 6 6.2 CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
44274716 96866 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 514 8 1 8 4.0 CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL26548 96866 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 514 8 1 8 4.0 CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
54178446 63767 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 435 4 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
CHEMBL1801712 63767 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 435 4 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
44291782 183415 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 456 8 1 5 5.4 CCCCC1=NC(C)(C2CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL47985 183415 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 456 8 1 5 5.4 CCCCC1=NC(C)(C2CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81140-9
14956755 106147 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 469 8 1 7 4.4 CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL313579 106147 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 469 8 1 7 4.4 CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
10202093 206433 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 417 8 1 7 3.9 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL87985 206433 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 417 8 1 7 3.9 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
11443112 106629 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 484 6 1 5 6.6 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(Cl)nc3ccccc23)cc1 10.1021/jm031100t
CHEMBL314315 106629 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 484 6 1 5 6.6 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(Cl)nc3ccccc23)cc1 10.1021/jm031100t
158781 44164 None 98 Bovine Binding pIC50 = 8.1 8.1 - 0
Displacement of radiolabeled angiotensin 2 from angiotensin AT1 receptor in bovine adrenal cortex membranesDisplacement of radiolabeled angiotensin 2 from angiotensin AT1 receptor in bovine adrenal cortex membranes
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1516 44164 None 98 Bovine Binding pIC50 = 8.1 8.1 - 0
Displacement of radiolabeled angiotensin 2 from angiotensin AT1 receptor in bovine adrenal cortex membranesDisplacement of radiolabeled angiotensin 2 from angiotensin AT1 receptor in bovine adrenal cortex membranes
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
10048120 119490 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 426 7 1 7 4.4 CCCCc1nn2c(C)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL345404 119490 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 426 7 1 7 4.4 CCCCc1nn2c(C)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
14951059 206427 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 493 10 1 8 4.2 CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL87942 206427 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 493 10 1 8 4.2 CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
10346399 47581 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 514 12 2 6 6.0 CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL154640 47581 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 514 12 2 6 6.0 CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
11758329 116913 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 603 12 0 8 6.0 CCCCc1ncc(/C=C2/C(=O)N(CCCC(F)(F)F)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL338431 116913 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 603 12 0 8 6.0 CCCCc1ncc(/C=C2/C(=O)N(CCCC(F)(F)F)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
14956776 105966 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 389 7 1 7 2.8 CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL313017 105966 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 389 7 1 7 2.8 CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
10346399 47581 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 514 12 2 6 6.0 CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL154640 47581 None 0 Rabbit Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 514 12 2 6 6.0 CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
24828705 157700 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 443 7 1 7 4.0 CCCCn1c(=O)c2cc(F)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL408188 157700 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 443 7 1 7 4.0 CCCCn1c(=O)c2cc(F)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
127036108 136376 None 0 Human Binding pIC50 = 7.2 7.2 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 561 11 2 5 6.8 CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735098 136376 None 0 Human Binding pIC50 = 7.2 7.2 - 1
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 561 11 2 5 6.8 CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
10368898 18895 None 0 Guinea pig Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 469 9 1 6 5.6 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCCF)ccc2n1 10.1021/jm00100a007
CHEMBL128389 18895 None 0 Guinea pig Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 469 9 1 6 5.6 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCCF)ccc2n1 10.1021/jm00100a007
9932352 16912 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 428 9 1 4 6.0 CCCCc1ncc(/C=C(\Cc2ccc(C)s2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
CHEMBL125212 16912 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 428 9 1 4 6.0 CCCCc1ncc(/C=C(\Cc2ccc(C)s2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
44341797 110637 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 362 4 1 3 4.1 CC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL325751 110637 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 362 4 1 3 4.1 CC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
44274706 96750 None 0 Bovine Binding pIC50 = 5.2 5.2 - 0
Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortexConcentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortex
ChEMBL 518 8 2 6 5.5 CCCCc1nc2cc(C3=NN(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)C(=O)CC3C)ccc2[nH]1 10.1016/S0960-894X(01)80348-6
CHEMBL26449 96750 None 0 Bovine Binding pIC50 = 5.2 5.2 - 0
Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortexConcentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortex
ChEMBL 518 8 2 6 5.5 CCCCc1nc2cc(C3=NN(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)C(=O)CC3C)ccc2[nH]1 10.1016/S0960-894X(01)80348-6
71653750 89149 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 671 11 2 7 6.7 CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2337679 89149 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 671 11 2 7 6.7 CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2365906 89149 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 671 11 2 7 6.7 CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
44289028 101181 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 418 7 1 3 5.5 CCCCC1=NCC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81139-2
CHEMBL295646 101181 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membraneIn vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
ChEMBL 418 7 1 3 5.5 CCCCC1=NCC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81139-2
10320063 18140 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 422 10 1 7 4.1 CCCCc1nc(CCCC)n(Cc2ccc(-n3c(F)ccc3-c3nn[nH]n3)cc2)n1 10.1021/jm00053a013
CHEMBL12693 18140 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 422 10 1 7 4.1 CCCCc1nc(CCCC)n(Cc2ccc(-n3c(F)ccc3-c3nn[nH]n3)cc2)n1 10.1021/jm00053a013
76329881 84951 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 490 11 2 8 4.9 CCCCc1nnc(SCC(C)C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237585 84951 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 490 11 2 8 4.9 CCCCc1nnc(SCC(C)C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
15780085 118148 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 617 9 1 7 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL34082 118148 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 617 9 1 7 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
9981071 119465 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 447 10 1 7 5.3 CCCCc1nnc(SCC(C)C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL345181 119465 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 447 10 1 7 5.3 CCCCc1nnc(SCC(C)C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
10345129 49115 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 481 11 3 7 3.5 CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL156181 49115 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 481 11 3 7 3.5 CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
10345129 49115 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 481 11 3 7 3.5 CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL156181 49115 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 481 11 3 7 3.5 CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
19792156 189993 None 0 Bovine Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL51712 189993 None 0 Bovine Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
19792156 189993 None 0 Bovine Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL51712 189993 None 0 Bovine Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
71611145 184860 None 2 Human Binding pIC50 = 4.1 4.1 - 0
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1072 29 14 13 -0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4852514 184860 None 2 Human Binding pIC50 = 4.1 4.1 - 0
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT1R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1072 29 14 13 -0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
127036866 137267 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 614 11 3 8 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752117 137267 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 614 11 3 8 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
127028930 137302 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 570 9 3 7 6.0 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752444 137302 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 570 9 3 7 6.0 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
44341488 9476 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 532 10 2 5 4.7 CCCCC1=NC2(CCN(C(=O)C(N)C(C)CC)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL111968 9476 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 532 10 2 5 4.7 CCCCC1=NC2(CCN(C(=O)C(N)C(C)CC)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
10455288 16852 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 428 9 1 4 6.0 CCCCc1ncc(/C=C(\Cc2sccc2C)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
CHEMBL124859 16852 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 428 9 1 4 6.0 CCCCc1ncc(/C=C(\Cc2sccc2C)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
127034904 136461 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 561 10 2 4 7.8 CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735831 136461 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 561 10 2 4 7.8 CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
11155548 206416 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 466 6 1 6 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(OC)nc3ccccc23)cc1 10.1021/jm031100t
CHEMBL87884 206416 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 466 6 1 6 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(OC)nc3ccccc23)cc1 10.1021/jm031100t
15069406 101746 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL299753 101746 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
15069406 101746 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL299753 101746 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 466 8 1 7 5.1 CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
53309405 63778 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 477 6 1 6 5.9 CCc1nc2c(CC(C)C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
CHEMBL1801742 63778 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 477 6 1 6 5.9 CCc1nc2c(CC(C)C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
10323718 119525 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 500 11 2 6 5.6 CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL345696 119525 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 500 11 2 6 5.6 CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
10323718 119525 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 500 11 2 6 5.6 CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL345696 119525 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 500 11 2 6 5.6 CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
127035380 136524 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 691 13 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736414 136524 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 691 13 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
24827904 96434 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 459 7 1 7 4.5 CCCCn1c(=O)c2cc(Cl)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL262098 96434 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 459 7 1 7 4.5 CCCCn1c(=O)c2cc(Cl)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
44297202 101748 None 0 Bovine Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 623 9 1 9 6.5 CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccccc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL299770 101748 None 0 Bovine Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 623 9 1 9 6.5 CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccccc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
44292497 14778 None 0 Bovine Binding pIC50 = 7.1 7.1 - 0
Binding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredBinding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measured
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@@]3(C)C[C@@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/S0960-894X(00)80366-2
CHEMBL1206677 14778 None 0 Bovine Binding pIC50 = 7.1 7.1 - 0
Binding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredBinding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measured
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@@]3(C)C[C@@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/S0960-894X(00)80366-2
CHEMBL295174 14778 None 0 Bovine Binding pIC50 = 7.1 7.1 - 0
Binding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredBinding affinity expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measured
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@@]3(C)C[C@@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/S0960-894X(00)80366-2
44287133 137607 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 439 8 1 7 4.4 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(c2ccccc2)c2nnn[nH]2)cc1 10.1016/0960-894X(94)00476-V
CHEMBL37565 137607 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 439 8 1 7 4.4 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(c2ccccc2)c2nnn[nH]2)cc1 10.1016/0960-894X(94)00476-V
10457332 51419 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 468 11 3 7 3.8 CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL158196 51419 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 468 11 3 7 3.8 CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
10457332 51419 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 468 11 3 7 3.8 CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL158196 51419 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 468 11 3 7 3.8 CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
46910581 76332 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 615 12 2 8 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058863 76332 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 615 12 2 8 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
10416836 107902 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 651 11 1 8 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 10.1021/jm00043a020
CHEMBL319313 107902 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 651 11 1 8 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 10.1021/jm00043a020
70690562 76325 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 571 10 2 7 6.1 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058856 76325 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 571 10 2 7 6.1 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
76319036 84978 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 537 12 3 9 4.7 CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237612 84978 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 537 12 3 9 4.7 CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
44307107 98693 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 417 4 1 6 3.9 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(C(=O)OC)c1 10.1016/S0960-894X(01)81148-3
CHEMBL277614 98693 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 417 4 1 6 3.9 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(C(=O)OC)c1 10.1016/S0960-894X(01)81148-3
10435850 48609 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 494 11 2 8 5.1 CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL155724 48609 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 494 11 2 8 5.1 CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
127035391 136409 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 563 10 2 5 7.4 CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735390 136409 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 563 10 2 5 7.4 CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
14956774 206236 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 452 8 1 8 3.7 CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL86741 206236 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 452 8 1 8 3.7 CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
15780095 98593 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 595 9 1 7 6.5 CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL276853 98593 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 595 9 1 7 6.5 CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44297217 101567 None 0 Bovine Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 651 10 1 9 6.5 CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL298509 101567 None 0 Bovine Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 651 10 1 9 6.5 CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
135723817 100767 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 470 8 2 8 5.0 CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
CHEMBL292914 100767 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 470 8 2 8 5.0 CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
44274692 96444 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 541 10 2 7 6.2 CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL26217 96444 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 541 10 2 7 6.2 CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
10324870 113311 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 535 12 0 8 5.1 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cscn2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL331546 113311 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 535 12 0 8 5.1 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cscn2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
11758341 117281 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 603 13 1 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 10.1007/s00044-009-9205-9
CHEMBL339544 117281 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 603 13 1 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 10.1007/s00044-009-9205-9
44306652 203340 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 437 3 1 4 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(Br)c1 10.1016/S0960-894X(01)81148-3
CHEMBL64983 203340 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 437 3 1 4 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(Br)c1 10.1016/S0960-894X(01)81148-3
44311584 102778 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 695 16 1 8 8.1 CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL305239 102778 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 695 16 1 8 8.1 CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(00)80077-3
19771800 206378 None 0 Guinea pig Binding pIC50 = 8.1 8.1 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparation
ChEMBL 441 7 1 6 5.0 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(OC)c2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
CHEMBL87603 206378 None 0 Guinea pig Binding pIC50 = 8.1 8.1 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to AT1 receptor in guinea pig adrenal membrane preparation
ChEMBL 441 7 1 6 5.0 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(OC)c2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
20747575 98422 None 0 Human Binding pIC50 = 8.1 8.1 - 1
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 579 12 2 8 5.0 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 10.1039/C4MD00499J
CHEMBL275545 98422 None 0 Human Binding pIC50 = 8.1 8.1 - 1
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 579 12 2 8 5.0 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 10.1039/C4MD00499J
127035085 136430 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 661 12 2 7 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735574 136430 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 661 12 2 7 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44285327 168599 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 430 6 1 6 3.6 CCCC1=NC2(CCOCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL435953 168599 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 430 6 1 6 3.6 CCCC1=NC2(CCOCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80526-6
44311496 204242 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 722 15 2 8 7.2 CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL71069 204242 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 722 15 2 8 7.2 CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1016/S0960-894X(00)80076-1
44379350 120783 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 599 10 1 7 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL355443 120783 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
ChEMBL 599 10 1 7 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1016/S0960-894X(01)81125-2
9843950 100569 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 400 8 1 6 4.1 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL291582 100569 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 400 8 1 6 4.1 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81124-0
14950510 85693 None 0 Guinea pig Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 413 7 1 6 4.6 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(C)=O)c(C)n1 10.1021/jm00061a016
CHEMBL22879 85693 None 0 Guinea pig Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 413 7 1 6 4.6 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(C)=O)c(C)n1 10.1021/jm00061a016
15171369 99464 None 0 Guinea pig Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 397 6 1 5 4.6 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCC2 10.1021/jm00061a016
CHEMBL283110 99464 None 0 Guinea pig Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 397 6 1 5 4.6 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCC2 10.1021/jm00061a016
10345638 20510 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 494 8 2 6 5.4 CCCCc1nc2ccc(NC(=O)N(C)C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
CHEMBL130746 20510 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 494 8 2 6 5.4 CCCCc1nc2ccc(NC(=O)N(C)C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00077a007
1610 2345 None 95 Human Binding pIC50 = 8.1 8.1 1 4
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81117-3
3941 2345 None 95 Human Binding pIC50 = 8.1 8.1 1 4
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81117-3
3961 2345 None 95 Human Binding pIC50 = 8.1 8.1 1 4
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81117-3
590 2345 None 95 Human Binding pIC50 = 8.1 8.1 1 4
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81117-3
CHEMBL191 2345 None 95 Human Binding pIC50 = 8.1 8.1 1 4
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81117-3
DB00678 2345 None 95 Human Binding pIC50 = 8.1 8.1 1 4
Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81117-3
19385601 51914 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 491 9 1 5 6.5 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1Cl 10.1016/0960-894X(95)00185-V
CHEMBL15860 51914 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 491 9 1 5 6.5 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1Cl 10.1016/0960-894X(95)00185-V
158781 44164 None 98 Bovine Binding pIC50 = 8.1 8.1 - 0
Binding affinity to angiotensin AT1 receptor in bovine adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in bovine adrenal cortex membranes
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1516 44164 None 98 Bovine Binding pIC50 = 8.1 8.1 - 0
Binding affinity to angiotensin AT1 receptor in bovine adrenal cortex membranesBinding affinity to angiotensin AT1 receptor in bovine adrenal cortex membranes
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
158781 44164 None 98 Bovine Binding pIC50 = 8.1 8.1 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/jm950450f
CHEMBL1516 44164 None 98 Bovine Binding pIC50 = 8.1 8.1 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/jm950450f
9874508 204678 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL73876 204678 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10223724 205755 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 417 9 1 7 3.7 CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL82797 205755 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 417 9 1 7 3.7 CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
53309271 63771 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 447 4 1 6 5.3 Cc1cc(C)c2nc(C3CC3)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 10.1021/jm200409s
CHEMBL1801735 63771 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 447 4 1 6 5.3 Cc1cc(C)c2nc(C3CC3)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 10.1021/jm200409s
1610 2345 None 95 Rat Binding pIC50 = 8.1 8.1 -1 4
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00370-9
3941 2345 None 95 Rat Binding pIC50 = 8.1 8.1 -1 4
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00370-9
3961 2345 None 95 Rat Binding pIC50 = 8.1 8.1 -1 4
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00370-9
590 2345 None 95 Rat Binding pIC50 = 8.1 8.1 -1 4
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00370-9
CHEMBL191 2345 None 95 Rat Binding pIC50 = 8.1 8.1 -1 4
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00370-9
DB00678 2345 None 95 Rat Binding pIC50 = 8.1 8.1 -1 4
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/0960-894X(95)00370-9
10414273 114545 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 518 12 0 7 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccoc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL333722 114545 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 518 12 0 7 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccoc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
44277872 96564 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 689 13 0 9 7.7 CCCCCN(C(=O)c1ccc(OCc2ccccc2)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
CHEMBL263038 96564 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 689 13 0 9 7.7 CCCCCN(C(=O)c1ccc(OCc2ccccc2)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 10.1016/0960-894X(95)00224-H
10256564 16264 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 533 12 0 8 5.0 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)on2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL122458 16264 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 533 12 0 8 5.0 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)on2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
10391038 116930 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 494 13 0 6 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL338514 116930 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 494 13 0 6 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
70694737 76216 None 0 Bovine Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 544 10 1 7 6.5 CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058372 76216 None 0 Bovine Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 544 10 1 7 6.5 CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
44342046 110546 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 432 7 1 3 6.1 CCCCC1=NC2(CCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL325201 110546 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 432 7 1 3 6.1 CCCCC1=NC2(CCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
10226439 203874 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 459 12 1 7 4.9 CCCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O 10.1021/jm00067a015
CHEMBL68760 203874 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 459 12 1 7 4.9 CCCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O 10.1021/jm00067a015
44376822 120051 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 565 10 1 7 5.5 CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL350493 120051 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
ChEMBL 565 10 1 7 5.5 CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
10439858 16859 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL124903 16859 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44384872 59993 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 575 9 3 7 4.4 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/0960-894X(96)00116-3
CHEMBL173455 59993 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
ChEMBL 575 9 3 7 4.4 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/0960-894X(96)00116-3
76322692 84971 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 585 12 2 10 4.3 CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237605 84971 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 585 12 2 10 4.3 CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
10392565 168411 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 542 11 1 9 4.7 CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL434844 168411 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 542 11 1 9 4.7 CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
44274824 99261 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 535 11 2 7 5.8 CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(00)80335-2
CHEMBL281846 99261 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 535 11 2 7 5.8 CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(00)80335-2
14956747 205972 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL84630 205972 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
15356433 184002 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 548 12 3 6 5.5 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
CHEMBL48195 184002 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 548 12 3 6 5.5 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
44341802 111364 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 420 7 1 3 6.1 CCCCC1=NC2(CCCC2)C(=S)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL327018 111364 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 420 7 1 3 6.1 CCCCC1=NC2(CCCC2)C(=S)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
19422646 169442 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 430 9 1 3 5.5 CCCCC1=NC(C2CC2)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL44268 169442 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 430 9 1 3 5.5 CCCCC1=NC(C2CC2)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
19422646 169442 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 430 9 1 3 5.5 CCCCC1=NC(C2CC2)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
CHEMBL44268 169442 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
ChEMBL 430 9 1 3 5.5 CCCCC1=NC(C2CC2)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81140-9
15287893 161951 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 515 14 1 6 6.9 CCCCCCOc1ccccc1C(Oc1ccc(Cn2c(CCC)nc3c(C)ccnc32)cc1)C(=O)O 10.1016/0960-894X(94)00476-V
CHEMBL41566 161951 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 515 14 1 6 6.9 CCCCCCOc1ccccc1C(Oc1ccc(Cn2c(CCC)nc3c(C)ccnc32)cc1)C(=O)O 10.1016/0960-894X(94)00476-V
44293697 100249 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 596 13 1 9 5.7 CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)OC)cc1 10.1021/jm00064a007
CHEMBL288753 100249 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 596 13 1 9 5.7 CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)OC)cc1 10.1021/jm00064a007
44341607 10044 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 534 10 3 6 3.1 CCCCC1=NC2(CCN(C(=O)C(N)CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL115204 10044 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 534 10 3 6 3.1 CCCCC1=NC2(CCN(C(=O)C(N)CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
15654754 102076 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 439 7 3 7 3.3 CNCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL302127 102076 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 439 7 3 7 3.3 CNCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
11756569 116471 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 524 9 3 4 7.2 CCCCc1nc2cc(NC(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL336130 116471 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 524 9 3 4 7.2 CCCCc1nc2cc(NC(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
127035083 136354 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3734835 136354 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
24827901 159426 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 439 7 1 7 4.2 CCCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL410105 159426 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 439 7 1 7 4.2 CCCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
11754954 168390 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 481 8 1 4 6.3 CCCCc1nc2ccc(N3CCCCC3=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL434640 168390 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 481 8 1 4 6.3 CCCCc1nc2ccc(N3CCCCC3=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
71521504 86832 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 581 6 1 7 6.2 CCc1nc2ccn(Cc3cccc(C(F)(F)F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322450 86832 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 581 6 1 7 6.2 CCc1nc2ccn(Cc3cccc(C(F)(F)F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
44309398 102263 None 0 Bovine Binding pIC50 = 4.1 4.1 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 546 6 1 3 5.5 CCCCc1nc2ccccc2n1CCc1cc(I)c(O)c(I)c1 10.1016/S0960-894X(01)81149-5
CHEMBL303247 102263 None 0 Bovine Binding pIC50 = 4.1 4.1 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 546 6 1 3 5.5 CCCCc1nc2ccccc2n1CCc1cc(I)c(O)c(I)c1 10.1016/S0960-894X(01)81149-5
44320733 206453 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 386 5 1 5 4.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ncccc2C(=O)O)cc1 10.1021/jm031100t
CHEMBL88081 206453 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 386 5 1 5 4.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ncccc2C(=O)O)cc1 10.1021/jm031100t
127036865 137422 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 584 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753406 137422 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 584 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
15654743 168153 None 0 Bovine Binding pIC50 = 7.1 7.1 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 438 6 2 6 4.8 CC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL433099 168153 None 0 Bovine Binding pIC50 = 7.1 7.1 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 438 6 2 6 4.8 CC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
44283175 120368 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 637 8 1 7 7.1 Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL35324 120368 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 637 8 1 7 7.1 Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10028815 208093 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 496 8 1 6 4.4 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 10.1021/jm00043a020
CHEMBL97783 208093 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 496 8 1 6 4.4 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 10.1021/jm00043a020
10250336 18884 None 0 Rat Binding pIC50 = 6.1 6.1 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 399 7 2 4 5.4 CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL128318 18884 None 0 Rat Binding pIC50 = 6.1 6.1 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 399 7 2 4 5.4 CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
44310590 204366 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneIn vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 385 5 1 4 4.9 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81150-1
CHEMBL71730 204366 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneIn vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 385 5 1 4 4.9 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81150-1
44305654 100780 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 502 8 1 8 4.8 CCCCc1cc(=O)n2nc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL293001 100780 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
ChEMBL 502 8 1 8 4.8 CCCCc1cc(=O)n2nc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
71653748 89148 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 627 11 2 7 6.6 CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2337678 89148 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 627 11 2 7 6.6 CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
CHEMBL2365905 89148 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 627 11 2 7 6.6 CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2012.12.044
44293406 184865 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 458 10 2 7 3.6 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)Cn2cccc2C(=O)OC)cc1 10.1021/jm00064a007
CHEMBL48526 184865 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 458 10 2 7 3.6 CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)Cn2cccc2C(=O)OC)cc1 10.1021/jm00064a007
15654744 102145 None 0 Bovine Binding pIC50 = 7.1 7.1 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 436 6 2 6 4.5 O=C(O)c1cccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 10.1021/jm00067a016
CHEMBL302520 102145 None 0 Bovine Binding pIC50 = 7.1 7.1 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 436 6 2 6 4.5 O=C(O)c1cccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 10.1021/jm00067a016
10502342 169073 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 422 9 2 6 3.9 CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
CHEMBL439743 169073 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 422 9 2 6 3.9 CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm950450f
10502342 169073 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 422 9 2 6 3.9 CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
CHEMBL439743 169073 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125l]-All binding to bovine adrenal cortexInhibition of [125l]-All binding to bovine adrenal cortex
ChEMBL 422 9 2 6 3.9 CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81143-4
44287536 161923 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 381 9 1 5 4.4 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(CCC)C(=O)O)cc1 10.1016/0960-894X(94)00476-V
CHEMBL41534 161923 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Tested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 1 binding affinity using rabbit aorta binding assay
ChEMBL 381 9 1 5 4.4 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(CCC)C(=O)O)cc1 10.1016/0960-894X(94)00476-V
76328690 105244 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 528 9 1 5 7.7 CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmcl.2014.01.004
CHEMBL3115242 105244 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 528 9 1 5 7.7 CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmcl.2014.01.004
44315059 204710 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74144 204710 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44307257 102598 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 326 4 1 6 3.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(O)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)81148-3
CHEMBL304116 102598 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
ChEMBL 326 4 1 6 3.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(O)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)81148-3
135723836 101038 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 486 8 2 8 5.7 CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
CHEMBL294598 101038 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MDisplacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M
ChEMBL 486 8 2 8 5.7 CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00319-O
15654733 204335 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 466 8 1 8 4.3 C=CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL71550 204335 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 466 8 1 8 4.3 C=CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
10250278 20332 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 398 7 1 3 6.1 CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
CHEMBL130600 20332 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 398 7 1 3 6.1 CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00077a007
15288898 204277 None 0 Bovine Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 280 5 1 3 4.1 CCCCc1nc2ccccc2n1Cc1ccc(O)cc1 10.1016/S0960-894X(01)81149-5
CHEMBL71254 204277 None 0 Bovine Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
ChEMBL 280 5 1 3 4.1 CCCCc1nc2ccccc2n1Cc1ccc(O)cc1 10.1016/S0960-894X(01)81149-5
44303883 202900 None 0 Rabbit Binding pIC50 = 5.1 5.1 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 634 11 1 3 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62744 202900 None 0 Rabbit Binding pIC50 = 5.1 5.1 - 0
Inhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assayInhibition of angiotensin Angiotensin II receptor, type 1 in rabbit aorta using [125I-Sar1,Ile8] angiotensin II binding assay
ChEMBL 634 11 1 3 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
14950500 99572 None 0 Guinea pig Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 401 7 1 6 4.3 COCc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C 10.1021/jm00061a016
CHEMBL283770 99572 None 0 Guinea pig Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 401 7 1 6 4.3 COCc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C 10.1021/jm00061a016
10457997 18833 None 1 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 483 11 2 4 6.9 CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1021/jm00077a007
CHEMBL128049 18833 None 1 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
ChEMBL 483 11 2 4 6.9 CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1021/jm00077a007
76308196 84992 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 410 8 3 6 3.9 CCCCc1nnc(S)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL2237877 84992 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 410 8 3 6 3.9 CCCCc1nnc(S)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
10021888 49380 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 367 7 2 5 4.3 CCCCc1nnc(S)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL156408 49380 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 367 7 2 5 4.3 CCCCc1nnc(S)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
10346301 168384 None 0 Guinea pig Binding pIC50 = 6.1 6.1 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 475 6 1 5 6.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(F)(F)F)ccc2n1 10.1021/jm00100a007
CHEMBL434615 168384 None 0 Guinea pig Binding pIC50 = 6.1 6.1 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 475 6 1 5 6.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(F)(F)F)ccc2n1 10.1021/jm00100a007
44373238 97085 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 1051 29 11 12 1.9 CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O 10.1021/jm9504722
CHEMBL267354 97085 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 1051 29 11 12 1.9 CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O 10.1021/jm9504722
44300735 100758 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 629 9 1 9 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL292829 100758 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
ChEMBL 629 9 1 9 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
127035558 136345 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 577 11 2 5 7.8 CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3734763 136345 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 577 11 2 5 7.8 CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
127026027 137271 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 628 12 3 8 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752145 137271 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 628 12 3 8 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
19792197 194932 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 480 8 1 7 5.4 CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL54194 194932 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 480 8 1 7 5.4 CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
19792197 194932 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 480 8 1 7 5.4 CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL54194 194932 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 480 8 1 7 5.4 CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
10457516 16785 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 472 10 1 7 5.0 CCCCc1nc(CCCC)n(Cc2ccc(-n3c(-c4nn[nH]n4)ccc3C(F)(F)F)cc2)n1 10.1021/jm00053a013
CHEMBL12451 16785 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 472 10 1 7 5.0 CCCCc1nc(CCCC)n(Cc2ccc(-n3c(-c4nn[nH]n4)ccc3C(F)(F)F)cc2)n1 10.1021/jm00053a013
1610 2345 None 95 Human Binding pIC50 = 7.1 7.1 1 4
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
3941 2345 None 95 Human Binding pIC50 = 7.1 7.1 1 4
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
3961 2345 None 95 Human Binding pIC50 = 7.1 7.1 1 4
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
590 2345 None 95 Human Binding pIC50 = 7.1 7.1 1 4
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
CHEMBL191 2345 None 95 Human Binding pIC50 = 7.1 7.1 1 4
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
DB00678 2345 None 95 Human Binding pIC50 = 7.1 7.1 1 4
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
19919870 85259 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 604 13 0 6 7.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL2259781 85259 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 604 13 0 6 7.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
76315366 84947 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 549 11 2 8 4.4 CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237581 84947 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 549 11 2 8 4.4 CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
9986953 46591 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 506 10 1 7 4.8 CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL153825 46591 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 506 10 1 7 4.8 CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
76315367 84949 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 466 9 2 6 5.5 CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL2237583 84949 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 466 9 2 6 5.5 CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44341791 9970 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 419 7 2 4 4.1 CCCCC1=NC2(CCNCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL114771 9970 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 419 7 2 4 4.1 CCCCC1=NC2(CCNCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
10002423 49225 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 423 8 1 5 5.9 CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL156279 49225 None 0 Rabbit Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 423 8 1 5 5.9 CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
15699061 5306 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 376 7 2 4 3.6 CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(C(=O)O)C2 10.1021/jm00114a021
CHEMBL106682 5306 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsBinding affinity against angiotensin II receptor in rat smooth muscle cell preparations
ChEMBL 376 7 2 4 3.6 CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(C(=O)O)C2 10.1021/jm00114a021
44274772 98635 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 493 8 2 7 4.6 CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL277182 98635 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 493 8 2 7 4.6 CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
10369902 164635 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 535 11 0 8 5.0 CCCCc1ncc(/C=C2/C(=O)N(CCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL421629 164635 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 535 11 0 8 5.0 CCCCc1ncc(/C=C2/C(=O)N(CCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
44274772 98635 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 493 8 2 7 4.6 CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL277182 98635 None 0 Rabbit Binding pIC50 = 8.1 8.1 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 493 8 2 7 4.6 CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80334-0
44311616 102138 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL302485 102138 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311571 204453 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL72249 204453 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
11328757 205965 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 464 6 1 5 6.3 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 10.1021/jm031100t
CHEMBL84573 205965 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 464 6 1 5 6.3 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 10.1021/jm031100t
15171413 106956 None 0 Guinea pig Binding pIC50 = 8.1 8.1 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 429 6 1 5 5.1 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
CHEMBL314982 106956 None 0 Guinea pig Binding pIC50 = 8.1 8.1 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 429 6 1 5 5.1 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
15818746 124067 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 529 8 1 5 5.3 CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL36324 124067 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]- Ang II from type 1 Angiotensin II receptorDisplacement of [125I]- Ang II from type 1 Angiotensin II receptor
ChEMBL 529 8 1 5 5.3 CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
44311567 103011 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 607 11 2 8 6.4 CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306922 103011 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro binding affinity of compound against Angiotensin II receptor, type 1In vitro binding affinity of compound against Angiotensin II receptor, type 1
ChEMBL 607 11 2 8 6.4 CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
14950509 83423 None 0 Guinea pig Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 443 8 1 7 4.6 CCCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 10.1021/jm00061a016
CHEMBL21968 83423 None 0 Guinea pig Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
ChEMBL 443 8 1 7 4.6 CCCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 10.1021/jm00061a016
14951064 203728 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 461 10 1 9 2.8 CCCCc1nn(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL67764 203728 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 461 10 1 9 2.8 CCCCc1nn(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
70684239 76215 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 528 9 1 6 6.8 CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058371 76215 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 528 9 1 6 6.8 CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
10763626 169549 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 402 8 2 6 3.8 CCCCn1ncc(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2011.05.056
CHEMBL443559 169549 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation countingDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting
ChEMBL 402 8 2 6 3.8 CCCCn1ncc(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.ejmech.2011.05.056
10834137 10060 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 388 7 2 6 3.4 CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
CHEMBL115273 10060 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 388 7 2 6 3.4 CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
44277487 99270 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccn4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL281891 99270 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 604 8 0 9 5.5 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccn4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
10457566 202800 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 473 8 1 8 1.9 CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
CHEMBL62269 202800 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexTested for binding affinity against angiotensin II receptor in bovine adrenal cortex
ChEMBL 473 8 1 8 1.9 CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00370-9
14956771 206351 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 482 8 1 9 3.8 CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
CHEMBL87392 206351 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
ChEMBL 482 8 1 9 3.8 CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9197-5
44277938 101147 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 599 10 1 9 4.8 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCC(=O)O)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL29540 101147 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 599 10 1 9 4.8 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCC(=O)O)C(=O)c4ccccc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
9912098 108538 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 460 9 3 7 4.0 CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
CHEMBL320135 108538 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexIn vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
ChEMBL 460 9 3 7 4.0 CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm950450f
19385680 98879 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 487 10 1 6 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC 10.1016/0960-894X(95)00185-V
CHEMBL279103 98879 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 487 10 1 6 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC 10.1016/0960-894X(95)00185-V
76330395 85410 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 567 12 0 9 5.3 CCCCc1ncc(/C=C2/C(=O)N(CSCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL2263543 85410 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 567 12 0 9 5.3 CCCCc1ncc(/C=C2/C(=O)N(CSCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
44277593 99409 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 661 9 0 10 5.9 COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 10.1016/0960-894X(95)00224-H
CHEMBL282778 99409 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity against AT1 receptor in human adrenal tissueBinding affinity against AT1 receptor in human adrenal tissue
ChEMBL 661 9 0 10 5.9 COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 10.1016/0960-894X(95)00224-H
44277567 101395 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 605 8 0 10 4.9 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
CHEMBL29725 101395 None 0 Rabbit Binding pIC50 = 8.0 8.0 - 0
Binding affinity against AT1 receptor in rabbit aortaBinding affinity against AT1 receptor in rabbit aorta
ChEMBL 605 8 0 10 4.9 Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 10.1016/0960-894X(95)00224-H
10482886 15512 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 558 13 0 7 5.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(OC)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL121718 15512 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 558 13 0 7 5.7 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(OC)cc2)n1Cc1ccc(C(=O)OC)cc1 10.1007/s00044-009-9205-9
70694738 76217 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 548 9 1 6 7.2 CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058373 76217 None 0 Bovine Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 548 9 1 6 7.2 CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
17748251 93345 None 0 Bovine Binding pIC50 = 8.0 8.0 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 455 8 1 8 4.2 CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL245444 93345 None 0 Bovine Binding pIC50 = 8.0 8.0 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 455 8 1 8 4.2 CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
1610 2345 None 95 Rat Binding pIC50 = 8.0 8.0 -1 4
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(96)00250-8
3941 2345 None 95 Rat Binding pIC50 = 8.0 8.0 -1 4
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(96)00250-8
3961 2345 None 95 Rat Binding pIC50 = 8.0 8.0 -1 4
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(96)00250-8
590 2345 None 95 Rat Binding pIC50 = 8.0 8.0 -1 4
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(96)00250-8
CHEMBL191 2345 None 95 Rat Binding pIC50 = 8.0 8.0 -1 4
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(96)00250-8
DB00678 2345 None 95 Rat Binding pIC50 = 8.0 8.0 -1 4
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(96)00250-8
14951069 203865 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 517 14 1 9 4.4 CCCCc1nn(CCCCCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL68719 203865 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 517 14 1 9 4.4 CCCCc1nn(CCCCCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
10006693 17041 None 0 Human Binding pIC50 = 8 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 514 11 1 6 5.4 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 10.1007/s00044-009-9205-9
CHEMBL125454 17041 None 0 Human Binding pIC50 = 8 8.0 - 0
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
ChEMBL 514 11 1 6 5.4 CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 10.1007/s00044-009-9205-9
70686382 76214 None 0 Bovine Binding pIC50 = 8 8.0 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 514 9 1 6 6.5 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058370 76214 None 0 Bovine Binding pIC50 = 8 8.0 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 514 9 1 6 6.5 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
44294551 184401 None 0 Bovine Binding pIC50 = 7.1 7.1 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 487 9 1 6 5.3 CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(00)80474-6
CHEMBL48459 184401 None 0 Bovine Binding pIC50 = 7.1 7.1 - 1
Ability to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesAbility to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes
ChEMBL 487 9 1 6 5.3 CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(00)80474-6
76329883 84965 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 582 12 2 10 5.2 CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237599 84965 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 582 12 2 10 5.2 CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
127026338 137402 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 616 11 3 7 5.9 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753277 137402 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 616 11 3 7 5.9 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
10482404 47458 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 539 11 1 9 5.6 CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL154531 47458 None 0 Rabbit Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 539 11 1 9 5.6 CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
24828427 96830 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 439 7 1 7 4.2 CCCCn1c2nc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL265208 96830 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 439 7 1 7 4.2 CCCCn1c2nc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
9933179 18444 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 444 10 1 5 5.7 CCCCc1ncc(/C=C(\Cc2ccc(OC)s2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
CHEMBL127194 18444 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteriesInhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
ChEMBL 444 10 1 5 5.7 CCCCc1ncc(/C=C(\Cc2ccc(OC)s2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00099a013
127036103 136507 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 531 9 2 4 7.2 CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3736257 136507 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 531 9 2 4 7.2 CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
4286584 204944 None 10 Bovine Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 408 7 1 5 5.3 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL7641 204944 None 10 Bovine Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 408 7 1 5 5.3 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
44296954 101958 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 589 8 1 9 5.3 CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL301325 101958 None 0 Bovine Binding pIC50 = 6.1 6.1 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 589 8 1 9 5.3 CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
15662011 193357 None 0 Bovine Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 8 2 6 5.0 CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL52497 193357 None 0 Bovine Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 8 2 6 5.0 CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
10000596 20649 None 0 Guinea pig Binding pIC50 = 4.1 4.1 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 392 5 1 4 5.6 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2c1 10.1021/jm00100a007
CHEMBL130858 20649 None 0 Guinea pig Binding pIC50 = 4.1 4.1 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 392 5 1 4 5.6 Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2c1 10.1021/jm00100a007
4286584 204944 None 10 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 408 7 1 5 5.3 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL7641 204944 None 10 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 408 7 1 5 5.3 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
15662011 193357 None 0 Bovine Binding pIC50 = 5.0 5.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 8 2 6 5.0 CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL52497 193357 None 0 Bovine Binding pIC50 = 5.0 5.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 452 8 2 6 5.0 CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
14951065 203843 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 433 9 2 8 2.4 CCCCc1nn(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
CHEMBL68582 203843 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesInhibition of [125I]angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes
ChEMBL 433 9 2 8 2.4 CCCCc1nn(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a015
19792137 85364 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 494 9 1 7 5.8 CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-009-9182-z
CHEMBL2261752 85364 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 494 9 1 7 5.8 CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-009-9182-z
19792185 189444 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 1 6 5.3 CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL51349 189444 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 1 6 5.3 CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
19792137 85364 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 494 9 1 7 5.8 CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-009-9182-z
CHEMBL2261752 85364 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 494 9 1 7 5.8 CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-009-9182-z
19792185 189444 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 1 6 5.3 CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
CHEMBL51349 189444 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membraneDisplacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane
ChEMBL 438 8 1 6 5.3 CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1007/s00044-009-9182-z
44275059 100073 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 590 7 2 7 6.6 Cc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(00)80335-2
CHEMBL287253 100073 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 590 7 2 7 6.6 Cc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(00)80335-2
44459584 96633 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 426 7 1 4 5.5 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(00)80334-0
CHEMBL26352 96633 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Binding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissueBinding affinity against Angiotensin II type 1 Receptor in rabbit aortic tissue
ChEMBL 426 7 1 4 5.5 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(00)80334-0
15698058 187121 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 412 8 2 4 5.0 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00064a007
CHEMBL49170 187121 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 412 8 2 4 5.0 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00064a007
127035545 136367 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 721 14 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3734955 136367 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 721 14 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
70686380 76210 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 458 6 1 6 5.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3cnc4ccccc43)cc2)c1C 10.1016/j.bmc.2012.06.011
CHEMBL2058366 76210 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 458 6 1 6 5.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3cnc4ccccc43)cc2)c1C 10.1016/j.bmc.2012.06.011
44438900 147846 None 0 Bovine Binding pIC50 = 7.0 7.0 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 403 7 2 5 4.2 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL393305 147846 None 0 Bovine Binding pIC50 = 7.0 7.0 - 1
Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorDisplacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptor
ChEMBL 403 7 2 5 4.2 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
15171407 205989 None 0 Guinea pig Binding pIC50 = 7.0 7.0 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 445 6 1 5 5.6 CCc1cc(OCc2ccc(-c3ccc(Cl)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
CHEMBL84792 205989 None 0 Guinea pig Binding pIC50 = 7.0 7.0 - 0
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparationCompound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
ChEMBL 445 6 1 5 5.6 CCc1cc(OCc2ccc(-c3ccc(Cl)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/S0960-894X(01)80295-X
127026337 137542 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 658 13 3 9 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3754394 137542 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptorDisplacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
ChEMBL 658 13 3 9 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
15287882 49741 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 414 9 1 4 5.6 CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL15670 49741 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 414 9 1 4 5.6 CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
127034875 136350 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 547 10 3 5 6.2 CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3734819 136350 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 minsDisplacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
ChEMBL 547 10 3 5 6.2 CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
10389251 47656 None 0 Rabbit Binding pIC50 = 6.0 6.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 454 9 2 5 5.3 CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
CHEMBL154708 47656 None 0 Rabbit Binding pIC50 = 6.0 6.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 454 9 2 5 5.3 CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1007/s00044-011-9756-4
44293817 186375 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 534 11 2 5 6.7 CCCCc1nc2c(C)cccc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
CHEMBL48756 186375 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
ChEMBL 534 11 2 5 6.7 CCCCc1nc2c(C)cccc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 10.1021/jm00064a007
10389251 47656 None 0 Rabbit Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 454 9 2 5 5.3 CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
CHEMBL154708 47656 None 0 Rabbit Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 454 9 2 5 5.3 CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00057a009
15654718 102267 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
CHEMBL303264 102267 None 0 Bovine Binding pIC50 = 6.0 6.0 - 0
Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortexInhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex
ChEMBL 440 7 2 7 4.0 CCOc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00067a016
76319034 84959 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 572 12 2 8 6.4 CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237593 84959 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 572 12 2 8 6.4 CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
76322691 84962 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 554 12 2 9 5.4 CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237596 84962 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 554 12 2 9 5.4 CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
127034916 136398 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 668 12 2 8 6.6 CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735302 136398 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 668 12 2 8 6.6 CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10052714 49186 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 529 11 1 7 6.9 CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL156243 49186 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 529 11 1 7 6.9 CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
10029367 50680 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 511 11 1 8 5.8 CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL157565 50680 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 511 11 1 8 5.8 CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
44296945 101994 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 653 10 1 10 5.7 CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL301569 101994 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 653 10 1 10 5.7 CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
71521417 86827 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 581 6 1 7 6.2 CCc1nc2ccn(Cc3ccccc3C(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
CHEMBL2322446 86827 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
ChEMBL 581 6 1 7 6.2 CCc1nc2ccn(Cc3ccccc3C(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1016/j.bmcl.2012.11.088
44274747 99669 None 0 Rabbit Binding pIC50 = 6.0 6.0 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 621 8 2 9 6.2 O=C(O)c1ccccc1-c1ccc(-c2nc3ccc([N+](=O)[O-])cc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL284469 99669 None 0 Rabbit Binding pIC50 = 6.0 6.0 - 0
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
ChEMBL 621 8 2 9 6.2 O=C(O)c1ccccc1-c1ccc(-c2nc3ccc([N+](=O)[O-])cc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(00)80335-2
10475572 18613 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 391 10 1 4 5.4 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)n1 10.1021/jm00053a013
CHEMBL12766 18613 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane.
ChEMBL 391 10 1 4 5.4 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)n1 10.1021/jm00053a013
127034917 136533 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 654 12 2 8 6.2 CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736507 136533 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysisDisplacement of 125I-labeled Sar1-Ile8-angiotensin II from human AT1 receptor incubated for 2 hrs by gamma counting analysis
ChEMBL 654 12 2 8 6.2 CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
1610 2345 None 95 Bovine Binding pIC50 = 7.0 7.0 - 4
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.06.011
3941 2345 None 95 Bovine Binding pIC50 = 7.0 7.0 - 4
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.06.011
3961 2345 None 95 Bovine Binding pIC50 = 7.0 7.0 - 4
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.06.011
590 2345 None 95 Bovine Binding pIC50 = 7.0 7.0 - 4
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.06.011
CHEMBL191 2345 None 95 Bovine Binding pIC50 = 7.0 7.0 - 4
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.06.011
DB00678 2345 None 95 Bovine Binding pIC50 = 7.0 7.0 - 4
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.06.011
24828568 159603 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 424 7 1 5 4.8 CCCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL410325 159603 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 424 7 1 5 4.8 CCCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
44270367 163221 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 505 9 1 5 6.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 10.1016/0960-894X(95)00185-V
CHEMBL418354 163221 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
ChEMBL 505 9 1 5 6.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 10.1016/0960-894X(95)00185-V
44342001 9937 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 477 9 2 5 3.9 CCCCC1=NC2(CCN(CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
CHEMBL114590 9937 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
ChEMBL 477 9 2 5 3.9 CCCCC1=NC2(CCN(CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00074a018
4286584 204944 None 10 Rabbit Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 408 7 1 5 5.3 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL7641 204944 None 10 Rabbit Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 408 7 1 5 5.3 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
19008901 62641 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 435 4 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 10.1021/jm200409s
CHEMBL178380 62641 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
ChEMBL 435 4 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 10.1021/jm200409s
70688503 76327 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 601 11 2 8 6.1 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058858 76327 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting
ChEMBL 601 11 2 8 6.1 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
10005096 18896 None 0 Guinea pig Binding pIC50 = 6.0 6.0 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 437 7 1 6 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(OC)c2n1 10.1021/jm00100a007
CHEMBL128397 18896 None 0 Guinea pig Binding pIC50 = 6.0 6.0 - 0
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
ChEMBL 437 7 1 6 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(OC)c2n1 10.1021/jm00100a007
76317815 105247 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 555 10 2 6 6.6 CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmcl.2014.01.004
CHEMBL3115245 105247 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assayAntagonist activity at human AT1 receptor expressed in CHO cells measured after overnight incubation by luciferase reporter gene assay
ChEMBL 555 10 2 6 6.6 CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmcl.2014.01.004
76311801 84958 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 544 10 2 8 5.7 CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
CHEMBL2237592 84958 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Antagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aortaAntagonist activity at AT1 receptor in Oryctolagus cuniculus (rabbit) aorta
ChEMBL 544 10 2 8 5.7 CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 10.1007/s00044-011-9756-4
19976416 206174 None 1 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 416 10 1 7 4.3 CCCCc1nc(CCCC)n(Cc2ccc(-c3ncccc3-c3nn[nH]n3)cc2)n1 10.1021/jm031100t
CHEMBL86344 206174 None 1 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
ChEMBL 416 10 1 7 4.3 CCCCc1nc(CCCC)n(Cc2ccc(-c3ncccc3-c3nn[nH]n3)cc2)n1 10.1021/jm031100t
10032367 53986 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 501 9 1 7 6.1 CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
CHEMBL160573 53986 None 0 Rabbit Binding pIC50 = 7.0 7.0 - 0
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
ChEMBL 501 9 1 7 6.1 CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00057a009
22850888 194012 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 561 8 1 8 5.7 CCCCc1nc2ccc([C@H]3[C@@H]4CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL52791 194012 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 561 8 1 8 5.7 CCCCc1nc2ccc([C@H]3[C@@H]4CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
9894404 194667 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 575 8 1 9 4.9 CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
CHEMBL53174 194667 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexIn vitro binding affinity to angiotensin II receptor in bovine adrenal cortex
ChEMBL 575 8 1 9 4.9 CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80377-2
132387 162332 None 23 Rabbit Binding pKd = 10.3 10.3 9 3
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 414 8 2 6 4.0 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1016/S0960-894X(01)81142-2
CHEMBL416477 162332 None 23 Rabbit Binding pKd = 10.3 10.3 9 3
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 414 8 2 6 4.0 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1016/S0960-894X(01)81142-2
132387 162332 None 23 Rabbit Binding pKd = 10.1 10.1 9 3
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 10.1-10.7Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 10.1-10.7
ChEMBL 414 8 2 6 4.0 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1021/jm00098a018
CHEMBL416477 162332 None 23 Rabbit Binding pKd = 10.1 10.1 9 3
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 10.1-10.7Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 10.1-10.7
ChEMBL 414 8 2 6 4.0 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1021/jm00098a018
192314 114498 None 28 Rabbit Binding pKd = 9.9 9.9 15 3
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aortaCompound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta
ChEMBL 429 9 2 7 3.8 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O 10.1021/jm00098a018
CHEMBL1237157 114498 None 28 Rabbit Binding pKd = 9.9 9.9 15 3
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aortaCompound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta
ChEMBL 429 9 2 7 3.8 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O 10.1021/jm00098a018
CHEMBL333534 114498 None 28 Rabbit Binding pKd = 9.9 9.9 15 3
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aortaCompound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta
ChEMBL 429 9 2 7 3.8 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O 10.1021/jm00098a018
15657904 187480 None 4 Rabbit Binding pKd = 9.9 9.9 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 415 8 2 7 3.4 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O 10.1016/S0960-894X(01)81142-2
CHEMBL49410 187480 None 4 Rabbit Binding pKd = 9.9 9.9 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 415 8 2 7 3.4 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O 10.1016/S0960-894X(01)81142-2
10432780 164510 None 0 Rabbit Binding pKd = 9.6 9.6 10 3
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aortaCompound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta
ChEMBL 429 8 2 7 3.7 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O 10.1021/jm00098a018
CHEMBL421473 164510 None 0 Rabbit Binding pKd = 9.6 9.6 10 3
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aortaCompound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta
ChEMBL 429 8 2 7 3.7 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O 10.1021/jm00098a018
15657949 16913 None 0 Rabbit Binding pKd = 9.5 9.5 - 1
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aortaCompound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta
ChEMBL 428 9 2 6 4.4 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1021/jm00098a018
CHEMBL125218 16913 None 0 Rabbit Binding pKd = 9.5 9.5 - 1
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aortaCompound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta
ChEMBL 428 9 2 6 4.4 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1021/jm00098a018
CHEMBL5075338 214366 None 0 Human Binding pKd = 9.3 9.3 - 1
Binding affinity to AT1R (unknown origin) expressed in Escherichia coli strain BL 21 (DE3) incubated for 20 mins by SDS PAGE analysisBinding affinity to AT1R (unknown origin) expressed in Escherichia coli strain BL 21 (DE3) incubated for 20 mins by SDS PAGE analysis
ChEMBL None None None CCOC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@@H](C)NC(=O)/C=C/c1ccc(O)c(O)c1 10.1021/acs.jmedchem.1c00123
CHEMBL266899 210705 None 0 Human Binding pKd = 9.3 9.3 - 1
Binding affinity was determined against Angiotensin II receptor, type 1Binding affinity was determined against Angiotensin II receptor, type 1
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C 10.1021/jm9507744
127030943 139193 None 0 Human Binding pKd = 9.0 9.0 - 1
Binding affinity to human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingBinding affinity to human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787243 139193 None 0 Human Binding pKd = 9.0 9.0 - 1
Binding affinity to human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingBinding affinity to human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787375 139193 None 0 Human Binding pKd = 9.0 9.0 - 1
Binding affinity to human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingBinding affinity to human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787700 139193 None 0 Human Binding pKd = 9.0 9.0 - 1
Binding affinity to human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingBinding affinity to human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
44348262 16341 None 0 Rabbit Binding pKd = 9 9.0 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 469 6 1 6 4.0 CCOC(=O)/C=C1\C2C3CCC(C3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
CHEMBL122891 16341 None 0 Rabbit Binding pKd = 9 9.0 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 469 6 1 6 4.0 CCOC(=O)/C=C1\C2C3CCC(C3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
9912059 185354 None 0 Rabbit Binding pKd = 9 9.0 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 459 7 1 6 4.5 CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
CHEMBL48602 185354 None 0 Rabbit Binding pKd = 9 9.0 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 459 7 1 6 4.5 CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
10745817 119373 None 0 Rat Binding pKd = 8.9 8.9 - 1
The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.
ChEMBL 580 12 3 7 5.4 CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 10.1021/jm991050l
CHEMBL2111973 119373 None 0 Rat Binding pKd = 8.9 8.9 - 1
The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.
ChEMBL 580 12 3 7 5.4 CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 10.1021/jm991050l
CHEMBL344464 119373 None 0 Rat Binding pKd = 8.9 8.9 - 1
The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.
ChEMBL 580 12 3 7 5.4 CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 10.1021/jm991050l
CHEMBL428475 213445 None 0 Bovine Binding pKd = 8.9 8.9 - 1
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C 10.1021/jm9608669
10094936 16834 None 0 Rabbit Binding pKd = 8.8 8.8 9 3
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aortaCompound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta
ChEMBL 443 9 2 7 4.1 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O 10.1021/jm00098a018
CHEMBL1237156 16834 None 0 Rabbit Binding pKd = 8.8 8.8 9 3
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aortaCompound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta
ChEMBL 443 9 2 7 4.1 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O 10.1021/jm00098a018
CHEMBL124772 16834 None 0 Rabbit Binding pKd = 8.8 8.8 9 3
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aortaCompound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta
ChEMBL 443 9 2 7 4.1 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O 10.1021/jm00098a018
1610 2345 None 95 Rabbit Binding pKd = 8.8 8.8 -1 4
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81127-6
3941 2345 None 95 Rabbit Binding pKd = 8.8 8.8 -1 4
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81127-6
3961 2345 None 95 Rabbit Binding pKd = 8.8 8.8 -1 4
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81127-6
590 2345 None 95 Rabbit Binding pKd = 8.8 8.8 -1 4
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81127-6
CHEMBL191 2345 None 95 Rabbit Binding pKd = 8.8 8.8 -1 4
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81127-6
DB00678 2345 None 95 Rabbit Binding pKd = 8.8 8.8 -1 4
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81127-6
CHEMBL216830 209340 None 30 Human Binding pKd = 8.8 8.8 - 1
Binding affinity to human AT1 receptorBinding affinity to human AT1 receptor
ChEMBL None None None None 10.1021/acs.jmedchem.8b00435
127034873 136447 None 0 Rabbit Binding pKd = 8.8 8.8 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735744 136447 None 0 Rabbit Binding pKd = 8.8 8.8 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
127035715 136438 None 0 Rabbit Binding pKd = 8.7 8.7 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 545 10 2 4 7.2 CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735652 136438 None 0 Rabbit Binding pKd = 8.7 8.7 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 545 10 2 4 7.2 CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
10408684 169170 None 0 Rabbit Binding pKd = 8.7 8.7 - 1
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.70-8.83Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.70-8.83
ChEMBL 400 7 2 6 3.7 CCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1021/jm00098a018
CHEMBL440521 169170 None 0 Rabbit Binding pKd = 8.7 8.7 - 1
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.70-8.83Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.70-8.83
ChEMBL 400 7 2 6 3.7 CCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1021/jm00098a018
44348285 16430 None 0 Rabbit Binding pKd = 8 8.0 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 481 6 1 6 4.2 CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
CHEMBL123208 16430 None 0 Rabbit Binding pKd = 8 8.0 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 481 6 1 6 4.2 CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
44294528 102036 None 0 Rabbit Binding pKd = 8.0 8.0 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 440 8 1 9 3.4 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nnn2C 10.1016/S0960-894X(01)81142-2
CHEMBL301819 102036 None 0 Rabbit Binding pKd = 8.0 8.0 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 440 8 1 9 3.4 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nnn2C 10.1016/S0960-894X(01)81142-2
44294996 189791 None 0 Rabbit Binding pKd = 7 7.0 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 501 10 1 6 5.7 CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(01)81127-6
CHEMBL51622 189791 None 0 Rabbit Binding pKd = 7 7.0 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 501 10 1 6 5.7 CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(01)81127-6
10629796 96882 None 0 Bovine Binding pKd = 7.0 7.0 - 1
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL 989 27 12 12 -1.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C 10.1021/jm9608669
CHEMBL265681 96882 None 0 Bovine Binding pKd = 7.0 7.0 - 1
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL 989 27 12 12 -1.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C 10.1021/jm9608669
9957348 186723 None 0 Rabbit Binding pKd = 7.0 7.0 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 493 9 1 8 5.1 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)OC)cc12 10.1016/S0960-894X(01)81142-2
CHEMBL48868 186723 None 0 Rabbit Binding pKd = 7.0 7.0 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 493 9 1 8 5.1 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)OC)cc12 10.1016/S0960-894X(01)81142-2
11744384 32345 None 0 Rat Binding pKd = 7.9 7.9 - 1
The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.
ChEMBL 448 11 3 6 5.2 CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1021/jm991050l
CHEMBL141065 32345 None 0 Rat Binding pKd = 7.9 7.9 - 1
The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.
ChEMBL 448 11 3 6 5.2 CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1021/jm991050l
CHEMBL2111972 32345 None 0 Rat Binding pKd = 7.9 7.9 - 1
The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.
ChEMBL 448 11 3 6 5.2 CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1021/jm991050l
44294791 183932 None 0 Rabbit Binding pKd = 6.9 6.9 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 437 8 1 8 4.1 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2nccnc12 10.1016/S0960-894X(01)81142-2
CHEMBL48145 183932 None 0 Rabbit Binding pKd = 6.9 6.9 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 437 8 1 8 4.1 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2nccnc12 10.1016/S0960-894X(01)81142-2
9909542 177479 None 0 Rabbit Binding pKd = 7.9 7.9 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 411 7 2 7 3.6 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 10.1016/S0960-894X(01)81142-2
CHEMBL46392 177479 None 0 Rabbit Binding pKd = 7.9 7.9 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 411 7 2 7 3.6 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 10.1016/S0960-894X(01)81142-2
10365342 113493 None 0 Rabbit Binding pKd = 7.9 7.9 16 2
Compound was evaluated for in vitro potency against AT1 receptor in isolated rabbit aorta; value ranges from 7.91-7.97Compound was evaluated for in vitro potency against AT1 receptor in isolated rabbit aorta; value ranges from 7.91-7.97
ChEMBL 429 9 3 7 4.0 CCCCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1021/jm00098a018
CHEMBL331983 113493 None 0 Rabbit Binding pKd = 7.9 7.9 16 2
Compound was evaluated for in vitro potency against AT1 receptor in isolated rabbit aorta; value ranges from 7.91-7.97Compound was evaluated for in vitro potency against AT1 receptor in isolated rabbit aorta; value ranges from 7.91-7.97
ChEMBL 429 9 3 7 4.0 CCCCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1021/jm00098a018
44383615 165949 None 0 Rabbit Binding pKd = 7.9 7.9 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 471 6 1 6 4.7 CCOC(=O)/C=C1\CC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
CHEMBL425139 165949 None 0 Rabbit Binding pKd = 7.9 7.9 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 471 6 1 6 4.7 CCOC(=O)/C=C1\CC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
44294551 184401 None 0 Rabbit Binding pKd = 7.9 7.9 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 487 9 1 6 5.3 CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(01)81127-6
CHEMBL48459 184401 None 0 Rabbit Binding pKd = 7.9 7.9 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 487 9 1 6 5.3 CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(01)81127-6
9807638 187144 None 0 Rabbit Binding pKd = 7.9 7.9 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 471 6 1 6 4.7 CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
CHEMBL49192 187144 None 0 Rabbit Binding pKd = 7.9 7.9 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 471 6 1 6 4.7 CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
44294464 187787 None 0 Rabbit Binding pKd = 6.9 6.9 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 397 6 3 7 3.4 CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c[nH]nc2n1 10.1016/S0960-894X(01)81142-2
CHEMBL49587 187787 None 0 Rabbit Binding pKd = 6.9 6.9 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 397 6 3 7 3.4 CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c[nH]nc2n1 10.1016/S0960-894X(01)81142-2
71623945 136462 None 0 Rabbit Binding pKd = 7.8 7.8 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 571 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735839 136462 None 0 Rabbit Binding pKd = 7.8 7.8 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 571 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
44295057 101332 None 0 Rabbit Binding pKd = 7.8 7.8 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 473 7 1 6 4.8 CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
CHEMBL296731 101332 None 0 Rabbit Binding pKd = 7.8 7.8 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 473 7 1 6 4.8 CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
44294699 187294 None 0 Rabbit Binding pKd = 6.8 6.8 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 501 9 1 8 5.1 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2Cc1ccccc1 10.1016/S0960-894X(01)81142-2
CHEMBL49294 187294 None 0 Rabbit Binding pKd = 6.8 6.8 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 501 9 1 8 5.1 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2Cc1ccccc1 10.1016/S0960-894X(01)81142-2
CHEMBL408098 212698 None 0 Bovine Binding pKd = 5.8 5.8 - 1
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None CCCCCCCCCCCCCCCCCCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](CC2=CCCC=C2)C(=O)O)C(C)C)cc1 10.1021/jm9608669
CHEMBL268804 210762 None 0 Bovine Binding pKd = 7.8 7.8 -2 2
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)O)C(C)C)C(C)C 10.1021/jm9608669
CHEMBL406519 212610 None 0 Bovine Binding pKd = 7.8 7.8 - 1
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C 10.1021/jm9608669
1610 2345 None 95 Rabbit Binding pKd = 7.7 7.7 -1 4
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2015.09.010
3941 2345 None 95 Rabbit Binding pKd = 7.7 7.7 -1 4
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2015.09.010
3961 2345 None 95 Rabbit Binding pKd = 7.7 7.7 -1 4
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2015.09.010
590 2345 None 95 Rabbit Binding pKd = 7.7 7.7 -1 4
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2015.09.010
CHEMBL191 2345 None 95 Rabbit Binding pKd = 7.7 7.7 -1 4
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2015.09.010
DB00678 2345 None 95 Rabbit Binding pKd = 7.7 7.7 -1 4
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2015.09.010
44348369 16334 None 0 Rabbit Binding pKd = 7.7 7.7 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 495 6 1 6 4.5 CCOC(=O)/C=C1\C2C3C=CC(CCC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
CHEMBL122855 16334 None 0 Rabbit Binding pKd = 7.7 7.7 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 495 6 1 6 4.5 CCOC(=O)/C=C1\C2C3C=CC(CCC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
16133225 419 None 52 Human Binding pKd = 8.7 8.7 -1 4
Binding affinity was determined against Angiotensin II receptor, type 1Binding affinity was determined against Angiotensin II receptor, type 1
ChEMBL None None None None 10.1021/jm9507744
172198 419 None 52 Human Binding pKd = 8.7 8.7 -1 4
Binding affinity was determined against Angiotensin II receptor, type 1Binding affinity was determined against Angiotensin II receptor, type 1
ChEMBL None None None None 10.1021/jm9507744
2504 419 None 52 Human Binding pKd = 8.7 8.7 -1 4
Binding affinity was determined against Angiotensin II receptor, type 1Binding affinity was determined against Angiotensin II receptor, type 1
ChEMBL None None None None 10.1021/jm9507744
45266664 419 None 52 Human Binding pKd = 8.7 8.7 -1 4
Binding affinity was determined against Angiotensin II receptor, type 1Binding affinity was determined against Angiotensin II receptor, type 1
ChEMBL None None None None 10.1021/jm9507744
5272 419 None 52 Human Binding pKd = 8.7 8.7 -1 4
Binding affinity was determined against Angiotensin II receptor, type 1Binding affinity was determined against Angiotensin II receptor, type 1
ChEMBL None None None None 10.1021/jm9507744
CHEMBL408403 419 None 52 Human Binding pKd = 8.7 8.7 -1 4
Binding affinity was determined against Angiotensin II receptor, type 1Binding affinity was determined against Angiotensin II receptor, type 1
ChEMBL None None None None 10.1021/jm9507744
DB11842 419 None 52 Human Binding pKd = 8.7 8.7 -1 4
Binding affinity was determined against Angiotensin II receptor, type 1Binding affinity was determined against Angiotensin II receptor, type 1
ChEMBL None None None None 10.1021/jm9507744
9912059 185354 None 0 Rabbit Binding pKd = 8.6 8.6 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 459 7 1 6 4.5 CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
CHEMBL48602 185354 None 0 Rabbit Binding pKd = 8.6 8.6 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 459 7 1 6 4.5 CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
44294466 187907 None 0 Rabbit Binding pKd = 8.6 8.6 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 451 7 3 7 4.4 CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)O)ccc2n1 10.1016/S0960-894X(01)81142-2
CHEMBL49663 187907 None 0 Rabbit Binding pKd = 8.6 8.6 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 451 7 3 7 4.4 CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)O)ccc2n1 10.1016/S0960-894X(01)81142-2
44294483 101744 None 0 Rabbit Binding pKd = 8.6 8.6 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 437 7 2 7 4.7 CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 10.1016/S0960-894X(01)81142-2
CHEMBL299741 101744 None 0 Rabbit Binding pKd = 8.6 8.6 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 437 7 2 7 4.7 CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 10.1016/S0960-894X(01)81142-2
15294417 184117 None 0 Rabbit Binding pKd = 8.5 8.5 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 407 6 2 6 4.7 CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1016/S0960-894X(01)81142-2
CHEMBL48270 184117 None 0 Rabbit Binding pKd = 8.5 8.5 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 407 6 2 6 4.7 CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1016/S0960-894X(01)81142-2
CHEMBL415025 213167 None 0 Human Binding pKd = 7.7 7.7 - 1
Binding affinity was determined against Angiotensin II receptor, type 1Binding affinity was determined against Angiotensin II receptor, type 1
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCSS[C@@H]2C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(C)C 10.1021/jm9507744
CHEMBL384349 212321 None 0 Bovine Binding pKd = 6.7 6.7 -2 2
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccc3ccccc3c2)C(=O)O)C(C)C)cc1 10.1021/jm9608669
CHEMBL402669 212527 None 0 Bovine Binding pKd = 5.7 5.7 - 1
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)O)C(C)C)C(C)C 10.1021/jm9608669
CHEMBL406170 212595 None 0 Human Binding pKd = 5.6 5.6 - 1
Binding affinity was determined against Angiotensin II receptor, type 1Binding affinity was determined against Angiotensin II receptor, type 1
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CSS[C@@H]2C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(C)C 10.1021/jm9507744
127035717 136414 None 0 Rabbit Binding pKd = 7.6 7.6 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735409 136414 None 0 Rabbit Binding pKd = 7.6 7.6 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
10701559 155689 None 0 Bovine Binding pKd = 5.6 5.6 - 1
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL 1227 42 11 13 4.9 CCCCCCCCCCCCCCCC(=O)OCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C 10.1021/jm9608669
CHEMBL405031 155689 None 0 Bovine Binding pKd = 5.6 5.6 - 1
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL 1227 42 11 13 4.9 CCCCCCCCCCCCCCCC(=O)OCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C 10.1021/jm9608669
44294540 101838 None 0 Rabbit Binding pKd = 7.5 7.5 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 455 8 2 9 3.7 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(O)n2C 10.1016/S0960-894X(01)81142-2
CHEMBL300438 101838 None 0 Rabbit Binding pKd = 7.5 7.5 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 455 8 2 9 3.7 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(O)n2C 10.1016/S0960-894X(01)81142-2
9864307 16424 None 0 Rabbit Binding pKd = 5.5 5.5 - 1
Compound was evaluated for in vitro potency against Angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 5.53-5.69Compound was evaluated for in vitro potency against Angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 5.53-5.69
ChEMBL 373 6 3 7 2.6 O=C(O)c1cncnc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00098a018
CHEMBL123152 16424 None 0 Rabbit Binding pKd = 5.5 5.5 - 1
Compound was evaluated for in vitro potency against Angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 5.53-5.69Compound was evaluated for in vitro potency against Angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 5.53-5.69
ChEMBL 373 6 3 7 2.6 O=C(O)c1cncnc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00098a018
70682146 76329 None 0 Rabbit Binding pKd = 8.5 8.5 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL2058860 76329 None 0 Rabbit Binding pKd = 8.5 8.5 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
127036108 136376 None 0 Rabbit Binding pKd = 8.5 8.5 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 561 11 2 5 6.8 CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735098 136376 None 0 Rabbit Binding pKd = 8.5 8.5 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 561 11 2 5 6.8 CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
127035514 136421 None 0 Rabbit Binding pKd = 8.5 8.5 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 585 11 2 7 6.3 CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735446 136421 None 0 Rabbit Binding pKd = 8.5 8.5 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 585 11 2 7 6.3 CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
44382928 59209 None 0 Rabbit Binding pKd = 8.5 8.5 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 457 6 1 6 4.3 CCOC(=O)/C=C1\CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
CHEMBL170196 59209 None 0 Rabbit Binding pKd = 8.5 8.5 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 457 6 1 6 4.3 CCOC(=O)/C=C1\CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
9978737 118890 None 1 Rat Binding pKd = 8.5 8.5 - 1
The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.
ChEMBL 407 10 3 5 4.3 CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1021/jm991050l
CHEMBL2111971 118890 None 1 Rat Binding pKd = 8.5 8.5 - 1
The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.
ChEMBL 407 10 3 5 4.3 CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1021/jm991050l
CHEMBL342261 118890 None 1 Rat Binding pKd = 8.5 8.5 - 1
The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.The compound was evaluated for the direct binding of tritiated compound to the recombinant Angiotensin II receptor, type 1 stably expressed in CHO cells.
ChEMBL 407 10 3 5 4.3 CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1021/jm991050l
CHEMBL415157 213172 None 0 Bovine Binding pKd = 8.5 8.5 10 2
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)C(C)C)cc1 10.1021/jm9608669
127036107 136514 None 0 Rabbit Binding pKd = 8.4 8.4 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 561 11 2 5 6.8 CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3736319 136514 None 0 Rabbit Binding pKd = 8.4 8.4 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 561 11 2 5 6.8 CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
1610 2345 None 95 Rabbit Binding pKd = 8.4 8.4 -1 4
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81142-2
3941 2345 None 95 Rabbit Binding pKd = 8.4 8.4 -1 4
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81142-2
3961 2345 None 95 Rabbit Binding pKd = 8.4 8.4 -1 4
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81142-2
590 2345 None 95 Rabbit Binding pKd = 8.4 8.4 -1 4
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81142-2
CHEMBL191 2345 None 95 Rabbit Binding pKd = 8.4 8.4 -1 4
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81142-2
DB00678 2345 None 95 Rabbit Binding pKd = 8.4 8.4 -1 4
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81142-2
127036297 136425 None 0 Rabbit Binding pKd = 8.4 8.4 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 547 10 3 5 6.2 CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735492 136425 None 0 Rabbit Binding pKd = 8.4 8.4 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 547 10 3 5 6.2 CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
44382968 165221 None 0 Rabbit Binding pKd = 8.4 8.4 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 485 6 1 6 5.1 CCOC(=O)/C=C1\CC2(CCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
CHEMBL422912 165221 None 0 Rabbit Binding pKd = 8.4 8.4 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 485 6 1 6 5.1 CCOC(=O)/C=C1\CC2(CCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
44295009 187169 None 0 Rabbit Binding pKd = 8.4 8.4 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 473 8 1 6 4.9 CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
CHEMBL49207 187169 None 0 Rabbit Binding pKd = 8.4 8.4 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 473 8 1 6 4.9 CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
44294967 188353 None 0 Rabbit Binding pKd = 7.5 7.5 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 467 9 1 8 4.6 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(CC)n2C 10.1016/S0960-894X(01)81142-2
CHEMBL50109 188353 None 0 Rabbit Binding pKd = 7.5 7.5 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 467 9 1 8 4.6 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(CC)n2C 10.1016/S0960-894X(01)81142-2
155541125 172963 None 0 Human Binding pKd = 6.5 6.5 - 1
Binding affinity to human AT1 receptorBinding affinity to human AT1 receptor
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O 10.1021/acs.jmedchem.8b00435
CHEMBL4517561 172963 None 0 Human Binding pKd = 6.5 6.5 - 1
Binding affinity to human AT1 receptorBinding affinity to human AT1 receptor
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O 10.1021/acs.jmedchem.8b00435
44295090 101652 None 0 Rabbit Binding pKd = 7.5 7.5 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 487 9 1 6 5.3 CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(01)81127-6
CHEMBL299151 101652 None 0 Rabbit Binding pKd = 7.5 7.5 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 487 9 1 6 5.3 CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 10.1016/S0960-894X(01)81127-6
CHEMBL264230 210607 None 0 Bovine Binding pKd = 6.5 6.5 -3 2
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)O)C(C)C)C(C)C 10.1021/jm9608669
44294520 184286 None 0 Rabbit Binding pKd = 6.5 6.5 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 411 7 2 7 3.6 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nncc1-2 10.1016/S0960-894X(01)81142-2
CHEMBL48400 184286 None 0 Rabbit Binding pKd = 6.5 6.5 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 411 7 2 7 3.6 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nncc1-2 10.1016/S0960-894X(01)81142-2
44294485 172566 None 0 Rabbit Binding pKd = 7.5 7.5 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 479 9 2 7 5.0 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cc(C(=O)O)ccc12 10.1016/S0960-894X(01)81142-2
CHEMBL448727 172566 None 0 Rabbit Binding pKd = 7.5 7.5 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 479 9 2 7 5.0 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cc(C(=O)O)ccc12 10.1016/S0960-894X(01)81142-2
44295010 187242 None 0 Rabbit Binding pKd = 7.4 7.4 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 445 6 1 6 4.1 CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
CHEMBL49262 187242 None 0 Rabbit Binding pKd = 7.4 7.4 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 445 6 1 6 4.1 CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
44294515 191819 None 0 Rabbit Binding pKd = 7.4 7.4 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 501 9 1 9 3.8 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc([S+](C)[O-])n2C 10.1016/S0960-894X(01)81142-2
CHEMBL51987 191819 None 0 Rabbit Binding pKd = 7.4 7.4 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 501 9 1 9 3.8 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc([S+](C)[O-])n2C 10.1016/S0960-894X(01)81142-2
44294676 187768 None 0 Rabbit Binding pKd = 7.3 7.3 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 451 7 1 7 4.7 CCc1nc(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 10.1016/S0960-894X(01)81142-2
CHEMBL49573 187768 None 0 Rabbit Binding pKd = 7.3 7.3 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 451 7 1 7 4.7 CCc1nc(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 10.1016/S0960-894X(01)81142-2
44294616 188238 None 0 Rabbit Binding pKd = 7.3 7.3 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 465 9 1 7 5.3 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(OC)cc12 10.1016/S0960-894X(01)81142-2
CHEMBL49952 188238 None 0 Rabbit Binding pKd = 7.3 7.3 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 465 9 1 7 5.3 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(OC)cc12 10.1016/S0960-894X(01)81142-2
CHEMBL406888 212623 None 0 Bovine Binding pKd = 6.3 6.3 - 1
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C 10.1021/jm9608669
44294905 189147 None 0 Rabbit Binding pKd = 8.3 8.3 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 485 6 1 6 5.1 CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
CHEMBL51084 189147 None 0 Rabbit Binding pKd = 8.3 8.3 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 485 6 1 6 5.1 CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
44294465 187701 None 0 Rabbit Binding pKd = 8.3 8.3 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 411 6 2 8 3.4 CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ncn(C)c2n1 10.1016/S0960-894X(01)81142-2
CHEMBL49528 187701 None 0 Rabbit Binding pKd = 8.3 8.3 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 411 6 2 8 3.4 CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ncn(C)c2n1 10.1016/S0960-894X(01)81142-2
1610 2345 None 95 Rabbit Binding pKd = 8.3 8.3 -1 4
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.27-8.70Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.27-8.70
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00098a018
3941 2345 None 95 Rabbit Binding pKd = 8.3 8.3 -1 4
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.27-8.70Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.27-8.70
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00098a018
3961 2345 None 95 Rabbit Binding pKd = 8.3 8.3 -1 4
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.27-8.70Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.27-8.70
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00098a018
590 2345 None 95 Rabbit Binding pKd = 8.3 8.3 -1 4
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.27-8.70Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.27-8.70
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00098a018
CHEMBL191 2345 None 95 Rabbit Binding pKd = 8.3 8.3 -1 4
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.27-8.70Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.27-8.70
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00098a018
DB00678 2345 None 95 Rabbit Binding pKd = 8.3 8.3 -1 4
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.27-8.70Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.27-8.70
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00098a018
127035716 136432 None 0 Rabbit Binding pKd = 8.3 8.3 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 545 10 2 4 7.2 CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735588 136432 None 0 Rabbit Binding pKd = 8.3 8.3 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 545 10 2 4 7.2 CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
16133225 419 None 52 Bovine Binding pKd = 8.2 8.2 -14 4
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None None 10.1021/jm9608669
172198 419 None 52 Bovine Binding pKd = 8.2 8.2 -14 4
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None None 10.1021/jm9608669
2504 419 None 52 Bovine Binding pKd = 8.2 8.2 -14 4
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None None 10.1021/jm9608669
45266664 419 None 52 Bovine Binding pKd = 8.2 8.2 -14 4
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None None 10.1021/jm9608669
5272 419 None 52 Bovine Binding pKd = 8.2 8.2 -14 4
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None None 10.1021/jm9608669
CHEMBL408403 419 None 52 Bovine Binding pKd = 8.2 8.2 -14 4
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None None 10.1021/jm9608669
DB11842 419 None 52 Bovine Binding pKd = 8.2 8.2 -14 4
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None None 10.1021/jm9608669
CHEMBL414918 213159 None 0 Human Binding pKd = 7.2 7.2 - 1
Binding affinity was determined against Angiotensin II receptor, type 1Binding affinity was determined against Angiotensin II receptor, type 1
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C 10.1021/jm9507744
44348285 16430 None 0 Rabbit Binding pKd = 8.2 8.2 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 481 6 1 6 4.2 CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
CHEMBL123208 16430 None 0 Rabbit Binding pKd = 8.2 8.2 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 481 6 1 6 4.2 CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
44211278 186628 None 0 Rabbit Binding pKd = 8.2 8.2 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 480 9 2 8 4.4 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)nc12 10.1016/S0960-894X(01)81142-2
CHEMBL48799 186628 None 0 Rabbit Binding pKd = 8.2 8.2 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 480 9 2 8 4.4 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)nc12 10.1016/S0960-894X(01)81142-2
44211265 177469 None 0 Rabbit Binding pKd = 8.2 8.2 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 425 8 2 7 4.0 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 10.1016/S0960-894X(01)81142-2
CHEMBL46391 177469 None 0 Rabbit Binding pKd = 8.2 8.2 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 425 8 2 7 4.0 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 10.1016/S0960-894X(01)81142-2
127035515 136453 None 0 Rabbit Binding pKd = 8.2 8.2 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 585 11 2 7 6.3 CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3735769 136453 None 0 Rabbit Binding pKd = 8.2 8.2 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 585 11 2 7 6.3 CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
44339988 161005 None 0 Bovine Binding pKd = 5.2 5.2 -1 2
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL 989 27 12 12 -1.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C 10.1021/jm9608669
CHEMBL411624 161005 None 0 Bovine Binding pKd = 5.2 5.2 -1 2
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL 989 27 12 12 -1.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C 10.1021/jm9608669
44211267 177787 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 469 9 2 9 3.2 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2CC(=O)O 10.1016/S0960-894X(01)81142-2
CHEMBL46433 177787 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 469 9 2 9 3.2 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2CC(=O)O 10.1016/S0960-894X(01)81142-2
127036105 136516 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 547 10 3 5 6.2 CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3736336 136516 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 547 10 3 5 6.2 CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL412717 213018 None 0 Bovine Binding pKd = 8.1 8.1 - 1
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
ChEMBL None None None None 10.1021/jm9608669
127036106 136366 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 571 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL3734949 136366 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 571 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.ejmech.2015.09.010
44211263 192130 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 439 8 2 7 4.3 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nc(C)nc1-2 10.1016/S0960-894X(01)81142-2
CHEMBL52036 192130 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 439 8 2 7 4.3 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nc(C)nc1-2 10.1016/S0960-894X(01)81142-2
44295009 187169 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 473 8 1 6 4.9 CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
CHEMBL49207 187169 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
ChEMBL 473 8 1 6 4.9 CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81127-6
44294721 101218 None 0 Rabbit Binding pKd = 7.1 7.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 464 8 1 9 3.9 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C#N)n2C 10.1016/S0960-894X(01)81142-2
CHEMBL295935 101218 None 0 Rabbit Binding pKd = 7.1 7.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 464 8 1 9 3.9 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C#N)n2C 10.1016/S0960-894X(01)81142-2
10321186 15511 None 0 Rabbit Binding pKd = 7.1 7.1 - 1
Compound was evaluated for in vitro potency against Angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 7.13-7.17Compound was evaluated for in vitro potency against Angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 7.13-7.17
ChEMBL 443 9 2 7 4.0 CCCCc1ncc(C(=O)O)c(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1021/jm00098a018
CHEMBL121705 15511 None 0 Rabbit Binding pKd = 7.1 7.1 - 1
Compound was evaluated for in vitro potency against Angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 7.13-7.17Compound was evaluated for in vitro potency against Angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 7.13-7.17
ChEMBL 443 9 2 7 4.0 CCCCc1ncc(C(=O)O)c(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1021/jm00098a018
44294518 188275 None 0 Rabbit Binding pKd = 7.1 7.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 469 9 2 9 3.2 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(CC(=O)O)c12 10.1016/S0960-894X(01)81142-2
CHEMBL50007 188275 None 0 Rabbit Binding pKd = 7.1 7.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 469 9 2 9 3.2 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(CC(=O)O)c12 10.1016/S0960-894X(01)81142-2
CHEMBL216678 209335 None 0 Human Binding pKd = 6.1 6.1 - 1
Binding affinity was determined against Angiotensin II receptor, type 1Binding affinity was determined against Angiotensin II receptor, type 1
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(C)C 10.1021/jm9507744
44294610 188143 None 0 Rabbit Binding pKd = 6.1 6.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 436 8 1 7 4.7 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cccnc12 10.1016/S0960-894X(01)81142-2
CHEMBL49848 188143 None 0 Rabbit Binding pKd = 6.1 6.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 436 8 1 7 4.7 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cccnc12 10.1016/S0960-894X(01)81142-2
73346386 92614 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 531 10 2 4 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
CHEMBL2435818 92614 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
Antagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysisAntagonist activity against AT1 receptor in Japanese White rabbit aortic strips assessed as reduction in angiotension-2-induced contractile response after 60 mins by Schild's plot analysis
ChEMBL 531 10 2 4 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2015.09.010
10048997 15499 None 0 Rabbit Binding pKd = 8.1 8.1 14 2
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.08-8.22Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.08-8.22
ChEMBL 442 9 2 6 4.7 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ccc1C(=O)O 10.1021/jm00098a018
CHEMBL121635 15499 None 0 Rabbit Binding pKd = 8.1 8.1 14 2
Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.08-8.22Compound was evaluated for in vitro potency against angiotensin II receptor, type 1 in isolated rabbit aorta; value ranges from 8.08-8.22
ChEMBL 442 9 2 6 4.7 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ccc1C(=O)O 10.1021/jm00098a018
44211264 101808 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 439 8 1 8 4.0 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2C 10.1016/S0960-894X(01)81142-2
CHEMBL300194 101808 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 439 8 1 8 4.0 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2C 10.1016/S0960-894X(01)81142-2
44294618 188392 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 437 7 2 7 4.7 CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(OC)cccc2n1 10.1016/S0960-894X(01)81142-2
CHEMBL50174 188392 None 0 Rabbit Binding pKd = 8.1 8.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 437 7 2 7 4.7 CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(OC)cccc2n1 10.1016/S0960-894X(01)81142-2
44294637 163145 None 0 Rabbit Binding pKd = 7.1 7.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 451 8 2 7 5.0 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(O)cc12 10.1016/S0960-894X(01)81142-2
CHEMBL417910 163145 None 0 Rabbit Binding pKd = 7.1 7.1 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 451 8 2 7 5.0 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(O)cc12 10.1016/S0960-894X(01)81142-2
44294822 101157 None 0 Rabbit Binding pKd = 8.0 8.0 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 453 8 1 8 4.3 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C)n2C 10.1016/S0960-894X(01)81142-2
CHEMBL295498 101157 None 0 Rabbit Binding pKd = 8.0 8.0 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 453 8 1 8 4.3 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C)n2C 10.1016/S0960-894X(01)81142-2
44211277 187964 None 0 Rabbit Binding pKd = 8.0 8.0 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 479 9 2 7 5.0 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)cc12 10.1016/S0960-894X(01)81142-2
CHEMBL49715 187964 None 0 Rabbit Binding pKd = 8.0 8.0 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 479 9 2 7 5.0 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)cc12 10.1016/S0960-894X(01)81142-2
44294459 184106 None 0 Rabbit Binding pKd = 6.0 6.0 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 425 7 1 8 3.6 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(C)c12 10.1016/S0960-894X(01)81142-2
CHEMBL48259 184106 None 0 Rabbit Binding pKd = 6.0 6.0 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 425 7 1 8 3.6 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(C)c12 10.1016/S0960-894X(01)81142-2
44294539 164873 None 0 Rabbit Binding pKd = 7.0 7.0 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 426 7 1 8 4.2 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2oc(C)nc12 10.1016/S0960-894X(01)81142-2
CHEMBL422050 164873 None 0 Rabbit Binding pKd = 7.0 7.0 - 1
pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic ringspA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings
ChEMBL 426 7 1 8 4.2 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2oc(C)nc12 10.1016/S0960-894X(01)81142-2
CHEMBL216061 209314 None 15 Rat Binding pKi = 9.8 9.8 1 2
Binding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree CBinding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree C
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
16133225 419 None 52 Human Binding pKi = 9.8 9.8 -1 4
Displacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma countingDisplacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
172198 419 None 52 Human Binding pKi = 9.8 9.8 -1 4
Displacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma countingDisplacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
2504 419 None 52 Human Binding pKi = 9.8 9.8 -1 4
Displacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma countingDisplacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
45266664 419 None 52 Human Binding pKi = 9.8 9.8 -1 4
Displacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma countingDisplacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5272 419 None 52 Human Binding pKi = 9.8 9.8 -1 4
Displacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma countingDisplacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL408403 419 None 52 Human Binding pKi = 9.8 9.8 -1 4
Displacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma countingDisplacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
DB11842 419 None 52 Human Binding pKi = 9.8 9.8 -1 4
Displacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma countingDisplacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL938 215905 None 28 Human Binding pKi = 9.8 9.8 1 2
Binding affinity to human AT1 receptor by radioligand displacement assayBinding affinity to human AT1 receptor by radioligand displacement assay
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1016/j.ejmech.2013.01.044
CHEMBL938 215905 None 28 Human Binding pKi = 9.7 9.7 1 2
Binding affinity to AT1 receptor (unknown origin)Binding affinity to AT1 receptor (unknown origin)
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/ml500278g
1056 3369 None 116 Rat Binding pKi = 9.6 9.6 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1007/s00044-008-9152-x
2405 3369 None 116 Rat Binding pKi = 9.6 9.6 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1007/s00044-008-9152-x
77999 3369 None 116 Rat Binding pKi = 9.6 9.6 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1007/s00044-008-9152-x
CHEMBL121 3369 None 116 Rat Binding pKi = 9.6 9.6 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1007/s00044-008-9152-x
DB00412 3369 None 116 Rat Binding pKi = 9.6 9.6 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1007/s00044-008-9152-x
2583 3774 None 118 Rat Binding pKi = 9.6 9.6 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1007/s00044-008-9153-9
592 3774 None 118 Rat Binding pKi = 9.6 9.6 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1007/s00044-008-9153-9
65999 3774 None 118 Rat Binding pKi = 9.6 9.6 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1007/s00044-008-9153-9
CHEMBL1017 3774 None 118 Rat Binding pKi = 9.6 9.6 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1007/s00044-008-9153-9
DB00966 3774 None 118 Rat Binding pKi = 9.6 9.6 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1007/s00044-008-9153-9
2583 3774 None 118 Rat Binding pKi = 9.6 9.6 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1021/jm901272d
592 3774 None 118 Rat Binding pKi = 9.6 9.6 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1021/jm901272d
65999 3774 None 118 Rat Binding pKi = 9.6 9.6 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1021/jm901272d
CHEMBL1017 3774 None 118 Rat Binding pKi = 9.6 9.6 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1021/jm901272d
DB00966 3774 None 118 Rat Binding pKi = 9.6 9.6 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1021/jm901272d
CHEMBL411997 212966 None 0 Rat Binding pKi = 9.6 9.6 - 1
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL None None None NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CCSSCC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm011063a
16133225 419 None 52 Human Binding pKi = 9.6 9.6 -1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
172198 419 None 52 Human Binding pKi = 9.6 9.6 -1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
2504 419 None 52 Human Binding pKi = 9.6 9.6 -1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
45266664 419 None 52 Human Binding pKi = 9.6 9.6 -1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5272 419 None 52 Human Binding pKi = 9.6 9.6 -1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL408403 419 None 52 Human Binding pKi = 9.6 9.6 -1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
DB11842 419 None 52 Human Binding pKi = 9.6 9.6 -1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
10390188 207255 None 0 Human Binding pKi = 9.5 9.5 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 475 5 1 7 4.9 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 10.1021/jm00014a024
CHEMBL92950 207255 None 0 Human Binding pKi = 9.5 9.5 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 475 5 1 7 4.9 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 10.1021/jm00014a024
CHEMBL1076604 208477 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
16133225 419 None 52 Rat Binding pKi = 9.5 9.5 -2 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL None None None None 10.1021/jm011063a
172198 419 None 52 Rat Binding pKi = 9.5 9.5 -2 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL None None None None 10.1021/jm011063a
2504 419 None 52 Rat Binding pKi = 9.5 9.5 -2 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL None None None None 10.1021/jm011063a
45266664 419 None 52 Rat Binding pKi = 9.5 9.5 -2 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL None None None None 10.1021/jm011063a
5272 419 None 52 Rat Binding pKi = 9.5 9.5 -2 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL None None None None 10.1021/jm011063a
CHEMBL408403 419 None 52 Rat Binding pKi = 9.5 9.5 -2 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL None None None None 10.1021/jm011063a
DB11842 419 None 52 Rat Binding pKi = 9.5 9.5 -2 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL None None None None 10.1021/jm011063a
CHEMBL938 215905 None 28 Human Binding pKi = 9.5 9.5 1 2
Displacement of radiolabeled saralasin from human AT1 receptorDisplacement of radiolabeled saralasin from human AT1 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm8007618
CHEMBL1076602 208475 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
CHEMBL1076603 208476 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
6918 1027 None 35 Pig Binding pKi = 9.4 9.4 3 3
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2008.05.066
9804984 1027 None 35 Pig Binding pKi = 9.4 9.4 3 3
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2008.05.066
CHEMBL189568 1027 None 35 Pig Binding pKi = 9.4 9.4 3 3
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2008.05.066
10479983 207328 None 0 Human Binding pKi = 9.4 9.4 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 473 4 1 7 4.8 Cc1cc(C)c2nc(C3CC3)n(Cc3ccc4c(-c5nnn[nH]5)cc5ccccc5c(=O)c4c3)c2n1 10.1021/jm00014a024
CHEMBL93522 207328 None 0 Human Binding pKi = 9.4 9.4 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 473 4 1 7 4.8 Cc1cc(C)c2nc(C3CC3)n(Cc3ccc4c(-c5nnn[nH]5)cc5ccccc5c(=O)c4c3)c2n1 10.1021/jm00014a024
183134 204842 None 17 Rat Binding pKi = 9.4 9.4 - 1
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00070a012
CHEMBL7550 204842 None 17 Rat Binding pKi = 9.4 9.4 - 1
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00070a012
9826888 207875 None 0 Human Binding pKi = 9.3 9.3 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 490 6 1 8 4.6 CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2nc(OC)ccc2n1 10.1021/jm00014a024
CHEMBL96552 207875 None 0 Human Binding pKi = 9.3 9.3 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 490 6 1 8 4.6 CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2nc(OC)ccc2n1 10.1021/jm00014a024
10004498 207277 None 0 Human Binding pKi = 9.3 9.3 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 461 5 1 6 5.1 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Cc1ccccc1C=C2c1nnn[nH]1 10.1021/jm00014a024
CHEMBL93159 207277 None 0 Human Binding pKi = 9.3 9.3 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 461 5 1 6 5.1 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Cc1ccccc1C=C2c1nnn[nH]1 10.1021/jm00014a024
16133225 419 None 52 Human Binding pKi = 9.3 9.3 -1 4
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None None 10.1021/jm9015747
172198 419 None 52 Human Binding pKi = 9.3 9.3 -1 4
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None None 10.1021/jm9015747
2504 419 None 52 Human Binding pKi = 9.3 9.3 -1 4
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None None 10.1021/jm9015747
45266664 419 None 52 Human Binding pKi = 9.3 9.3 -1 4
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None None 10.1021/jm9015747
5272 419 None 52 Human Binding pKi = 9.3 9.3 -1 4
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None None 10.1021/jm9015747
CHEMBL408403 419 None 52 Human Binding pKi = 9.3 9.3 -1 4
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None None 10.1021/jm9015747
DB11842 419 None 52 Human Binding pKi = 9.3 9.3 -1 4
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None None 10.1021/jm9015747
CHEMBL1076663 208486 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C 10.1021/jm9015747
4673492 4136 None 9 Human Binding pKi = 9.3 9.3 - 1
Displacement of [tyrosyl-3,5-3H]angiotensin-2 from AT1 receptor (unknown origin) expressed in QBI-HEK293A cells after 2 hrsDisplacement of [tyrosyl-3,5-3H]angiotensin-2 from AT1 receptor (unknown origin) expressed in QBI-HEK293A cells after 2 hrs
ChEMBL 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 10.1016/j.bmc.2013.09.004
8324 4136 None 9 Human Binding pKi = 9.3 9.3 - 1
Displacement of [tyrosyl-3,5-3H]angiotensin-2 from AT1 receptor (unknown origin) expressed in QBI-HEK293A cells after 2 hrsDisplacement of [tyrosyl-3,5-3H]angiotensin-2 from AT1 receptor (unknown origin) expressed in QBI-HEK293A cells after 2 hrs
ChEMBL 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 10.1016/j.bmc.2013.09.004
CHEMBL159096 4136 None 9 Human Binding pKi = 9.3 9.3 - 1
Displacement of [tyrosyl-3,5-3H]angiotensin-2 from AT1 receptor (unknown origin) expressed in QBI-HEK293A cells after 2 hrsDisplacement of [tyrosyl-3,5-3H]angiotensin-2 from AT1 receptor (unknown origin) expressed in QBI-HEK293A cells after 2 hrs
ChEMBL 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 10.1016/j.bmc.2013.09.004
CHEMBL1076601 208474 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
46880544 208483 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O 10.1021/jm9015747
CHEMBL1076632 208483 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O 10.1021/jm9015747
132387 162332 None 23 Rat Binding pKi = 9.2 9.2 -9 3
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 414 8 2 6 4.0 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1021/jm00070a012
CHEMBL416477 162332 None 23 Rat Binding pKi = 9.2 9.2 -9 3
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 414 8 2 6 4.0 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1021/jm00070a012
44282952 120427 None 0 Rat Binding pKi = 9.2 9.2 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 511 7 2 8 3.8 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 10.1016/S0960-894X(97)00026-7
CHEMBL35381 120427 None 0 Rat Binding pKi = 9.2 9.2 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 511 7 2 8 3.8 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 10.1016/S0960-894X(97)00026-7
2541 785 None 120 Rabbit Binding pKi = 9.2 9.2 1 6
Inhibitory activity against Angiotensin II receptor, type 1 in rat adrenal membraneInhibitory activity against Angiotensin II receptor, type 1 in rat adrenal membrane
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm9504722
587 785 None 120 Rabbit Binding pKi = 9.2 9.2 1 6
Inhibitory activity against Angiotensin II receptor, type 1 in rat adrenal membraneInhibitory activity against Angiotensin II receptor, type 1 in rat adrenal membrane
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm9504722
6907 785 None 120 Rabbit Binding pKi = 9.2 9.2 1 6
Inhibitory activity against Angiotensin II receptor, type 1 in rat adrenal membraneInhibitory activity against Angiotensin II receptor, type 1 in rat adrenal membrane
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm9504722
CHEMBL1016 785 None 120 Rabbit Binding pKi = 9.2 9.2 1 6
Inhibitory activity against Angiotensin II receptor, type 1 in rat adrenal membraneInhibitory activity against Angiotensin II receptor, type 1 in rat adrenal membrane
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm9504722
DB00796 785 None 120 Rabbit Binding pKi = 9.2 9.2 1 6
Inhibitory activity against Angiotensin II receptor, type 1 in rat adrenal membraneInhibitory activity against Angiotensin II receptor, type 1 in rat adrenal membrane
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm9504722
DB13919 785 None 120 Rabbit Binding pKi = 9.2 9.2 1 6
Inhibitory activity against Angiotensin II receptor, type 1 in rat adrenal membraneInhibitory activity against Angiotensin II receptor, type 1 in rat adrenal membrane
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/jm9504722
10344188 112646 None 0 Human Binding pKi = 9.2 9.2 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 459 5 1 6 5.2 CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2ccccc2n1 10.1021/jm00014a024
CHEMBL330298 112646 None 0 Human Binding pKi = 9.2 9.2 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 459 5 1 6 5.2 CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2ccccc2n1 10.1021/jm00014a024
10079601 212529 None 14 Human Binding pKi = 9.2 9.2 -4 2
Binding affinity to AT1 receptor (unknown origin)Binding affinity to AT1 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1021/ml500278g
CHEMBL404594 212529 None 14 Human Binding pKi = 9.2 9.2 -4 2
Binding affinity to AT1 receptor (unknown origin)Binding affinity to AT1 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1021/ml500278g
10004489 206752 None 0 Human Binding pKi = 9.2 9.2 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 461 4 1 7 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 10.1021/jm00014a024
CHEMBL90027 206752 None 0 Human Binding pKi = 9.2 9.2 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 461 4 1 7 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 10.1021/jm00014a024
45102750 63776 None 4 Human Binding pKi = 9.2 9.2 - 1
Binding affinity to human Angiotensin receptor 1Binding affinity to human Angiotensin receptor 1
ChEMBL 477 6 1 6 5.9 CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
CHEMBL1801740 63776 None 4 Human Binding pKi = 9.2 9.2 - 1
Binding affinity to human Angiotensin receptor 1Binding affinity to human Angiotensin receptor 1
ChEMBL 477 6 1 6 5.9 CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 10.1021/jm200409s
11754146 159685 None 0 Human Binding pKi = 9.2 9.2 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 463 5 1 7 5.3 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 10.1021/jm00014a024
CHEMBL410417 159685 None 0 Human Binding pKi = 9.2 9.2 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 463 5 1 7 5.3 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 10.1021/jm00014a024
CHEMBL1076613 208479 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
CHEMBL1076633 208484 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)O 10.1021/jm9015747
CHEMBL1076662 208485 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C 10.1021/jm9015747
CHEMBL1076603 208476 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
11994289 82475 None 0 Pig Binding pKi = 9.2 9.2 -1 2
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2008.05.066
CHEMBL217673 82475 None 0 Pig Binding pKi = 9.2 9.2 -1 2
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2008.05.066
10031067 100350 None 4 Pig Binding pKi = 9.2 9.2 2 3
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2008.05.066
CHEMBL289614 100350 None 4 Pig Binding pKi = 9.2 9.2 2 3
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2008.05.066
127030943 139193 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787243 139193 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787375 139193 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787700 139193 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
132387 162332 None 23 Rat Binding pKi = 9.1 9.1 -12 3
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 414 8 2 6 4.0 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1021/jm00098a018
CHEMBL416477 162332 None 23 Rat Binding pKi = 9.1 9.1 -12 3
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 414 8 2 6 4.0 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1021/jm00098a018
87219032 175973 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 541 13 3 6 5.6 CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F 10.1021/acsmedchemlett.8b00462
CHEMBL4588688 175973 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 541 13 3 6 5.6 CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F 10.1021/acsmedchemlett.8b00462
9891811 119740 None 1 Rat Binding pKi = 9.1 9.1 8128 2
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 475 8 2 7 4.8 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL347703 119740 None 1 Rat Binding pKi = 9.1 9.1 8128 2
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 475 8 2 7 4.8 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL4524047 119740 None 1 Rat Binding pKi = 9.1 9.1 8128 2
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 475 8 2 7 4.8 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
1481 2064 None 116 Human Binding pKi = 9.1 9.1 1 3
Binding affinity to AT1 receptorBinding affinity to AT1 receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
3749 2064 None 116 Human Binding pKi = 9.1 9.1 1 3
Binding affinity to AT1 receptorBinding affinity to AT1 receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
589 2064 None 116 Human Binding pKi = 9.1 9.1 1 3
Binding affinity to AT1 receptorBinding affinity to AT1 receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
6908 2064 None 116 Human Binding pKi = 9.1 9.1 1 3
Binding affinity to AT1 receptorBinding affinity to AT1 receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
CHEMBL1513 2064 None 116 Human Binding pKi = 9.1 9.1 1 3
Binding affinity to AT1 receptorBinding affinity to AT1 receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
DB01029 2064 None 116 Human Binding pKi = 9.1 9.1 1 3
Binding affinity to AT1 receptorBinding affinity to AT1 receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
10257882 3644 None 43 Human Binding pKi = 9.1 9.1 11 2
Binding affinity to AT1 receptorBinding affinity to AT1 receptor
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm300682j
8448 3644 None 43 Human Binding pKi = 9.1 9.1 11 2
Binding affinity to AT1 receptorBinding affinity to AT1 receptor
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm300682j
CHEMBL539423 3644 None 43 Human Binding pKi = 9.1 9.1 11 2
Binding affinity to AT1 receptorBinding affinity to AT1 receptor
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm300682j
DB12548 3644 None 43 Human Binding pKi = 9.1 9.1 11 2
Binding affinity to AT1 receptorBinding affinity to AT1 receptor
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm300682j
1481 2064 None 116 Rat Binding pKi = 9.1 9.1 -1 3
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm020138n
3749 2064 None 116 Rat Binding pKi = 9.1 9.1 -1 3
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm020138n
589 2064 None 116 Rat Binding pKi = 9.1 9.1 -1 3
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm020138n
6908 2064 None 116 Rat Binding pKi = 9.1 9.1 -1 3
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm020138n
CHEMBL1513 2064 None 116 Rat Binding pKi = 9.1 9.1 -1 3
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm020138n
DB01029 2064 None 116 Rat Binding pKi = 9.1 9.1 -1 3
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm020138n
CHEMBL1076612 208478 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C(=O)c2ccccc2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
46880544 208483 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O 10.1021/jm9015747
CHEMBL1076632 208483 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O 10.1021/jm9015747
1481 2064 None 116 Human Binding pKi = 9.1 9.1 1 3
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm058225d
3749 2064 None 116 Human Binding pKi = 9.1 9.1 1 3
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm058225d
589 2064 None 116 Human Binding pKi = 9.1 9.1 1 3
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm058225d
6908 2064 None 116 Human Binding pKi = 9.1 9.1 1 3
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm058225d
CHEMBL1513 2064 None 116 Human Binding pKi = 9.1 9.1 1 3
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm058225d
DB01029 2064 None 116 Human Binding pKi = 9.1 9.1 1 3
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm058225d
10257882 3644 None 43 Human Binding pKi = 9.1 9.1 11 2
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm058225d
8448 3644 None 43 Human Binding pKi = 9.1 9.1 11 2
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm058225d
CHEMBL539423 3644 None 43 Human Binding pKi = 9.1 9.1 11 2
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm058225d
DB12548 3644 None 43 Human Binding pKi = 9.1 9.1 11 2
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm058225d
14956739 206300 None 0 Rabbit Binding pKi = 9.1 9.1 - 1
Binding affinity to Angiotensin II receptor, type 1Binding affinity to Angiotensin II receptor, type 1
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm990504b
CHEMBL87074 206300 None 0 Rabbit Binding pKi = 9.1 9.1 - 1
Binding affinity to Angiotensin II receptor, type 1Binding affinity to Angiotensin II receptor, type 1
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm990504b
3047757 167456 None 23 Rabbit Binding pKi = 9.1 9.1 - 1
Binding affinity was evaluated towards Angiotensin II receptor, type 1 in rabbit aortaBinding affinity was evaluated towards Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 554 10 1 9 5.2 CCCCc1nc(C)n(Cc2sccc2C(=O)OC)c(=O)c1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/jm9504722
CHEMBL429847 167456 None 23 Rabbit Binding pKi = 9.1 9.1 - 1
Binding affinity was evaluated towards Angiotensin II receptor, type 1 in rabbit aortaBinding affinity was evaluated towards Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 554 10 1 9 5.2 CCCCc1nc(C)n(Cc2sccc2C(=O)OC)c(=O)c1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/jm9504722
16133225 419 None 52 Human Binding pKi = 9.1 9.1 -1 4
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None None 10.1021/jm9015747
172198 419 None 52 Human Binding pKi = 9.1 9.1 -1 4
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None None 10.1021/jm9015747
2504 419 None 52 Human Binding pKi = 9.1 9.1 -1 4
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None None 10.1021/jm9015747
45266664 419 None 52 Human Binding pKi = 9.1 9.1 -1 4
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None None 10.1021/jm9015747
5272 419 None 52 Human Binding pKi = 9.1 9.1 -1 4
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None None 10.1021/jm9015747
CHEMBL408403 419 None 52 Human Binding pKi = 9.1 9.1 -1 4
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None None 10.1021/jm9015747
DB11842 419 None 52 Human Binding pKi = 9.1 9.1 -1 4
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None None 10.1021/jm9015747
CHEMBL1076633 208484 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)O 10.1021/jm9015747
16133225 419 None 52 Rat Binding pKi = 9.0 9.0 -2 4
Binding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree CBinding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
172198 419 None 52 Rat Binding pKi = 9.0 9.0 -2 4
Binding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree CBinding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
2504 419 None 52 Rat Binding pKi = 9.0 9.0 -2 4
Binding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree CBinding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
45266664 419 None 52 Rat Binding pKi = 9.0 9.0 -2 4
Binding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree CBinding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
5272 419 None 52 Rat Binding pKi = 9.0 9.0 -2 4
Binding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree CBinding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
CHEMBL408403 419 None 52 Rat Binding pKi = 9.0 9.0 -2 4
Binding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree CBinding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
DB11842 419 None 52 Rat Binding pKi = 9.0 9.0 -2 4
Binding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree CBinding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
10322229 121506 None 0 Human Binding pKi = 9 9.0 1 2
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 464 8 2 6 4.9 CCCCC1=NC(Cl)=C(C(=O)O)C(C)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL358335 121506 None 0 Human Binding pKi = 9 9.0 1 2
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 464 8 2 6 4.9 CCCCC1=NC(Cl)=C(C(=O)O)C(C)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
10410148 205128 None 0 Rat Binding pKi = 9 9.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 425 6 2 8 3.4 CCCc1nc(C)n2nc(N)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL77959 205128 None 0 Rat Binding pKi = 9 9.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 425 6 2 8 3.4 CCCc1nc(C)n2nc(N)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
25141239 183864 None 0 Pig Binding pKi = 9 9.0 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 528 11 2 6 5.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NCc2ccccc2)cc1 10.1016/j.bmc.2008.05.066
CHEMBL480906 183864 None 0 Pig Binding pKi = 9 9.0 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 528 11 2 6 5.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NCc2ccccc2)cc1 10.1016/j.bmc.2008.05.066
10322229 121506 None 0 Rat Binding pKi = 9 9.0 -1 2
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 464 8 2 6 4.9 CCCCC1=NC(Cl)=C(C(=O)O)C(C)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00103a014
CHEMBL358335 121506 None 0 Rat Binding pKi = 9 9.0 -1 2
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 464 8 2 6 4.9 CCCCC1=NC(Cl)=C(C(=O)O)C(C)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00103a014
10366402 206838 None 0 Human Binding pKi = 9.0 9.0 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 448 5 2 8 3.8 CCc1cc(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)n2nccc2n1 10.1021/jm00014a024
CHEMBL90513 206838 None 0 Human Binding pKi = 9.0 9.0 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 448 5 2 8 3.8 CCc1cc(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)n2nccc2n1 10.1021/jm00014a024
1481 2064 None 116 Human Binding pKi = 9.0 9.0 1 3
Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm020138n
3749 2064 None 116 Human Binding pKi = 9.0 9.0 1 3
Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm020138n
589 2064 None 116 Human Binding pKi = 9.0 9.0 1 3
Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm020138n
6908 2064 None 116 Human Binding pKi = 9.0 9.0 1 3
Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm020138n
CHEMBL1513 2064 None 116 Human Binding pKi = 9.0 9.0 1 3
Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm020138n
DB01029 2064 None 116 Human Binding pKi = 9.0 9.0 1 3
Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm020138n
3936 2208 None 35 Human Binding pKi = 9.0 9.0 1 4
Displacement of 125I-[Sar1,Ile8]ANGII form AT1 receptor (unknown origin)Displacement of 125I-[Sar1,Ile8]ANGII form AT1 receptor (unknown origin)
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
6603900 2208 None 35 Human Binding pKi = 9.0 9.0 1 4
Displacement of 125I-[Sar1,Ile8]ANGII form AT1 receptor (unknown origin)Displacement of 125I-[Sar1,Ile8]ANGII form AT1 receptor (unknown origin)
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
CHEMBL288174 2208 None 35 Human Binding pKi = 9.0 9.0 1 4
Displacement of 125I-[Sar1,Ile8]ANGII form AT1 receptor (unknown origin)Displacement of 125I-[Sar1,Ile8]ANGII form AT1 receptor (unknown origin)
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
3936 2208 None 35 Rat Binding pKi = 9.0 9.0 -1 4
Displacement of [125]Ang2 from AT1 receptor in rat liver membraneDisplacement of [125]Ang2 from AT1 receptor in rat liver membrane
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2008.05.066
6603900 2208 None 35 Rat Binding pKi = 9.0 9.0 -1 4
Displacement of [125]Ang2 from AT1 receptor in rat liver membraneDisplacement of [125]Ang2 from AT1 receptor in rat liver membrane
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2008.05.066
CHEMBL288174 2208 None 35 Rat Binding pKi = 9.0 9.0 -1 4
Displacement of [125]Ang2 from AT1 receptor in rat liver membraneDisplacement of [125]Ang2 from AT1 receptor in rat liver membrane
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2008.05.066
CHEMBL5274111 193793 None 0 Rat Binding pKi = 9.0 9.0 1 2
Displacement of [I125I]AngII form AT1 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting methodDisplacement of [I125I]AngII form AT1 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting method
ChEMBL 1060 30 14 13 -0.7 CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2022.128983
10006413 37483 None 0 Rat Binding pKi = 9.0 9.0 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 506 9 1 7 5.7 CCCCC1=NC(C)(C)C(C(=O)OCC)=C(Cl)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00103a014
CHEMBL145564 37483 None 0 Rat Binding pKi = 9.0 9.0 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 506 9 1 7 5.7 CCCCC1=NC(C)(C)C(C(=O)OCC)=C(Cl)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00103a014
14956757 67591 None 0 Rabbit Binding pKi = 8.9 8.9 - 1
Binding affinity to Angiotensin II receptor, type 1Binding affinity to Angiotensin II receptor, type 1
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm990504b
CHEMBL19018 67591 None 0 Rabbit Binding pKi = 8.9 8.9 - 1
Binding affinity to Angiotensin II receptor, type 1Binding affinity to Angiotensin II receptor, type 1
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm990504b
45102601 169569 None 12 Human Binding pKi = 8.9 8.9 1995 2
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 6 5.4 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F 10.1021/acsmedchemlett.8b00462
CHEMBL4435800 169569 None 12 Human Binding pKi = 8.9 8.9 1995 2
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 6 5.4 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F 10.1021/acsmedchemlett.8b00462
87218373 170243 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 541 13 3 6 5.6 CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 10.1021/acsmedchemlett.8b00462
CHEMBL4445778 170243 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 541 13 3 6 5.6 CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 10.1021/acsmedchemlett.8b00462
87218514 176084 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 523 13 3 6 5.5 CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4591218 176084 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 523 13 3 6 5.5 CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
10050044 111526 None 0 Human Binding pKi = 8.9 8.9 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 463 5 1 6 4.9 CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 10.1021/jm00014a024
CHEMBL327903 111526 None 0 Human Binding pKi = 8.9 8.9 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 463 5 1 6 4.9 CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 10.1021/jm00014a024
CHEMBL1076604 208477 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
145957897 162070 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 984 28 14 13 -1.8 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)O 10.1016/j.ejmech.2017.12.021
CHEMBL4160691 162070 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 984 28 14 13 -1.8 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)O 10.1016/j.ejmech.2017.12.021
44320012 167921 None 0 Rabbit Binding pKi = 8.9 8.9 - 1
Binding affinity to Angiotensin II receptor, type 1Binding affinity to Angiotensin II receptor, type 1
ChEMBL 493 9 1 7 5.4 CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm990504b
CHEMBL431411 167921 None 0 Rabbit Binding pKi = 8.9 8.9 - 1
Binding affinity to Angiotensin II receptor, type 1Binding affinity to Angiotensin II receptor, type 1
ChEMBL 493 9 1 7 5.4 CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm990504b
10603443 34810 None 0 Rat Binding pKi = 8.8 8.8 - 1
The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.
ChEMBL 587 13 3 8 5.6 CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2N=[N+]=[N-])cc1 10.1021/jm991050l
CHEMBL143118 34810 None 0 Rat Binding pKi = 8.8 8.8 - 1
The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.
ChEMBL 587 13 3 8 5.6 CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2N=[N+]=[N-])cc1 10.1021/jm991050l
9939191 98944 None 1 Human Binding pKi = 8.8 8.8 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL279629 98944 None 1 Human Binding pKi = 8.8 8.8 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL97539 98944 None 1 Human Binding pKi = 8.8 8.8 - 1
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/j.bmc.2010.10.043
10079766 96980 None 0 Rat Binding pKi = 8.8 8.8 - 1
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL 1045 22 13 14 -2.0 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CS/C=C/CC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm011063a
CHEMBL266450 96980 None 0 Rat Binding pKi = 8.8 8.8 - 1
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL 1045 22 13 14 -2.0 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CS/C=C/CC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm011063a
10011335 161266 None 0 Rat Binding pKi = 8.8 8.8 - 1
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL 1045 22 13 14 -2.0 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CS/C=C\CC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm011063a
CHEMBL412045 161266 None 0 Rat Binding pKi = 8.8 8.8 - 1
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL 1045 22 13 14 -2.0 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CS/C=C\CC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm011063a
192314 114498 None 28 Rat Binding pKi = 8.8 8.8 -15 3
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 429 9 2 7 3.8 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O 10.1021/jm00070a012
CHEMBL1237157 114498 None 28 Rat Binding pKi = 8.8 8.8 -15 3
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 429 9 2 7 3.8 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O 10.1021/jm00070a012
CHEMBL333534 114498 None 28 Rat Binding pKi = 8.8 8.8 -15 3
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 429 9 2 7 3.8 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O 10.1021/jm00070a012
72168 102685 None 24 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]-angiotensin 2 from angiotensin AT1 receptorDisplacement of [3H]-angiotensin 2 from angiotensin AT1 receptor
ChEMBL 554 8 2 7 6.0 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2oc(-c3ccccc3-c3nnn[nH]3)c(Br)c2c1 10.1016/j.bmc.2010.10.043
CHEMBL304639 102685 None 24 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]-angiotensin 2 from angiotensin AT1 receptorDisplacement of [3H]-angiotensin 2 from angiotensin AT1 receptor
ChEMBL 554 8 2 7 6.0 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2oc(-c3ccccc3-c3nnn[nH]3)c(Br)c2c1 10.1016/j.bmc.2010.10.043
10393016 206934 None 0 Human Binding pKi = 8 8.0 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 559 9 1 5 4.9 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9904147
CHEMBL91113 206934 None 0 Human Binding pKi = 8 8.0 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 559 9 1 5 4.9 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9904147
9895957 10671 None 18 Human Binding pKi = 8 8.0 -5 3
Binding affinity at type 1 angiotensin 2 receptorBinding affinity at type 1 angiotensin 2 receptor
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1016/j.bmc.2012.06.011
CHEMBL11706 10671 None 18 Human Binding pKi = 8 8.0 -5 3
Binding affinity at type 1 angiotensin 2 receptorBinding affinity at type 1 angiotensin 2 receptor
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1016/j.bmc.2012.06.011
9895957 10671 None 18 Human Binding pKi = 8 8.0 -5 3
Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1021/jm020138n
CHEMBL11706 10671 None 18 Human Binding pKi = 8 8.0 -5 3
Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1021/jm020138n
155514738 169907 None 0 Human Binding pKi = 8 8.0 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 656 15 4 8 5.3 CCCCc1nc(Cl)c(CNC(=O)CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4440944 169907 None 0 Human Binding pKi = 8 8.0 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 656 15 4 8 5.3 CCCCc1nc(Cl)c(CNC(=O)CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.8b00462
71465043 171974 None 0 Human Binding pKi = 8 8.0 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 565 13 3 7 6.0 CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(C)C)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4470834 171974 None 0 Human Binding pKi = 8 8.0 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 565 13 3 7 6.0 CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(C)C)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.8b00462
10409294 105389 None 0 Rat Binding pKi = 8 8.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 410 6 1 7 3.8 CCCc1nc(C)n2cnnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL311657 105389 None 0 Rat Binding pKi = 8 8.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 410 6 1 7 3.8 CCCc1nc(C)n2cnnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
10410197 163338 None 0 Rat Binding pKi = 8 8.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 426 6 2 8 3.5 CCCc1nc(C)n2c(O)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL419089 163338 None 0 Rat Binding pKi = 8 8.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 426 6 2 8 3.5 CCCc1nc(C)n2c(O)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
9933044 168019 None 0 Rat Binding pKi = 8 8.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 442 6 2 8 4.1 CCCc1nc(C)n2nc(S)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL432153 168019 None 0 Rat Binding pKi = 8 8.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 442 6 2 8 4.1 CCCc1nc(C)n2nc(S)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
10411083 205038 None 0 Rat Binding pKi = 8 8.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 442 7 3 9 2.7 CCCc1nc(CO)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL77036 205038 None 0 Rat Binding pKi = 8 8.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 442 7 3 9 2.7 CCCc1nc(CO)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
53319274 57598 None 0 Human Binding pKi = 8 8.0 - 1
Displacement of [3H]-angiotensin 2 from angiotensin AT1 receptor in human PLC-PRF5 cellsDisplacement of [3H]-angiotensin 2 from angiotensin AT1 receptor in human PLC-PRF5 cells
ChEMBL 559 9 1 7 4.2 CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O 10.1016/j.bmc.2010.10.043
CHEMBL1668000 57598 None 0 Human Binding pKi = 8 8.0 - 1
Displacement of [3H]-angiotensin 2 from angiotensin AT1 receptor in human PLC-PRF5 cellsDisplacement of [3H]-angiotensin 2 from angiotensin AT1 receptor in human PLC-PRF5 cells
ChEMBL 559 9 1 7 4.2 CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O 10.1016/j.bmc.2010.10.043
9895957 10671 None 18 Human Binding pKi = 8 8.0 -5 3
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1021/jm058225d
CHEMBL11706 10671 None 18 Human Binding pKi = 8 8.0 -5 3
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1021/jm058225d
2541 785 None 120 Human Binding pKi = 8.0 8.0 -1 6
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2017.12.021
587 785 None 120 Human Binding pKi = 8.0 8.0 -1 6
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2017.12.021
6907 785 None 120 Human Binding pKi = 8.0 8.0 -1 6
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2017.12.021
CHEMBL1016 785 None 120 Human Binding pKi = 8.0 8.0 -1 6
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2017.12.021
DB00796 785 None 120 Human Binding pKi = 8.0 8.0 -1 6
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2017.12.021
DB13919 785 None 120 Human Binding pKi = 8.0 8.0 -1 6
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2017.12.021
1610 2345 None 95 Human Binding pKi = 8.0 8.0 1 4
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2023.129349
3941 2345 None 95 Human Binding pKi = 8.0 8.0 1 4
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2023.129349
3961 2345 None 95 Human Binding pKi = 8.0 8.0 1 4
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2023.129349
590 2345 None 95 Human Binding pKi = 8.0 8.0 1 4
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2023.129349
CHEMBL191 2345 None 95 Human Binding pKi = 8.0 8.0 1 4
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2023.129349
DB00678 2345 None 95 Human Binding pKi = 8.0 8.0 1 4
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2023.129349
44567746 191414 None 0 Pig Binding pKi = 8.0 8.0 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 478 10 2 6 4.7 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CC2)cc1 10.1016/j.bmc.2008.05.066
CHEMBL519274 191414 None 0 Pig Binding pKi = 8.0 8.0 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 478 10 2 6 4.7 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CC2)cc1 10.1016/j.bmc.2008.05.066
CHEMBL5271484 193684 None 0 Human Binding pKi = 8.0 8.0 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 315 3 1 4 2.8 CS(=O)(=O)n1c(-c2ccccc2)c(C(=O)O)c2ccccc21 10.1016/j.bmcl.2023.129349
44567782 183722 None 0 Pig Binding pKi = 8.0 8.0 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 521 10 2 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)Nc2nccs2)cc1 10.1016/j.bmc.2008.05.066
CHEMBL480341 183722 None 0 Pig Binding pKi = 8.0 8.0 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 521 10 2 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)Nc2nccs2)cc1 10.1016/j.bmc.2008.05.066
87218444 171446 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 541 13 3 5 6.5 CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4463203 171446 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 541 13 3 5 6.5 CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
6918 1027 None 35 Human Binding pKi = 5 5.0 -25118 3
Binding affinity to AT1 receptor (unknown origin)Binding affinity to AT1 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/acs.jmedchem.8b00294
9804984 1027 None 35 Human Binding pKi = 5 5.0 -25118 3
Binding affinity to AT1 receptor (unknown origin)Binding affinity to AT1 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/acs.jmedchem.8b00294
CHEMBL189568 1027 None 35 Human Binding pKi = 5 5.0 -25118 3
Binding affinity to AT1 receptor (unknown origin)Binding affinity to AT1 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/acs.jmedchem.8b00294
19029492 118072 None 0 Rat Binding pKi = 7.0 7.0 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 485 6 1 7 4.3 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(F)cc2)s1 10.1016/S0960-894X(97)00026-7
CHEMBL340518 118072 None 0 Rat Binding pKi = 7.0 7.0 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 485 6 1 7 4.3 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(F)cc2)s1 10.1016/S0960-894X(97)00026-7
44567709 190657 None 0 Pig Binding pKi = 7.0 7.0 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 438 9 2 6 3.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(N)=O)cc1 10.1016/j.bmc.2008.05.066
CHEMBL518157 190657 None 0 Pig Binding pKi = 7.0 7.0 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 438 9 2 6 3.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(N)=O)cc1 10.1016/j.bmc.2008.05.066
10027078 205202 None 0 Rat Binding pKi = 7.0 7.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 456 7 2 8 4.5 CCCCc1nc(C)n2c(S)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL78532 205202 None 0 Rat Binding pKi = 7.0 7.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 456 7 2 8 4.5 CCCCc1nc(C)n2c(S)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL5272962 193739 None 0 Human Binding pKi = 8.0 8.0 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 341 3 1 3 4.7 O=C(O)c1c(-c2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 10.1016/j.bmcl.2023.129349
10074277 205368 None 0 Rat Binding pKi = 8.0 8.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 489 7 2 9 2.5 CCCc1nc(C)n2nc(S(N)(=O)=O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL79879 205368 None 0 Rat Binding pKi = 8.0 8.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 489 7 2 9 2.5 CCCc1nc(C)n2nc(S(N)(=O)=O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
10343950 205193 None 0 Rat Binding pKi = 7.0 7.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 454 8 1 8 4.0 CCCc1nc(COC)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL78433 205193 None 0 Rat Binding pKi = 7.0 7.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 454 8 1 8 4.0 CCCc1nc(COC)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
11754586 107088 None 0 Human Binding pKi = 7.9 7.9 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 472 7 1 7 4.6 CCCCc1nc(Cl)c(C=O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 10.1021/jm00014a024
CHEMBL315881 107088 None 0 Human Binding pKi = 7.9 7.9 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 472 7 1 7 4.6 CCCCc1nc(Cl)c(C=O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 10.1021/jm00014a024
10001600 104104 None 0 Rat Binding pKi = 7.9 7.9 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 410 6 1 7 3.8 CCCc1nc(C)n2ncnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL309384 104104 None 0 Rat Binding pKi = 7.9 7.9 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 410 6 1 7 3.8 CCCc1nc(C)n2ncnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
10391688 105731 None 0 Rat Binding pKi = 7.9 7.9 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 512 9 1 10 3.2 CCCc1nc(C)n2c(=O)n(CC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL312632 105731 None 0 Rat Binding pKi = 7.9 7.9 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 512 9 1 10 3.2 CCCc1nc(C)n2c(=O)n(CC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
1610 2345 None 95 Human Binding pKi = 7.9 7.9 1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.5b01495
3941 2345 None 95 Human Binding pKi = 7.9 7.9 1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.5b01495
3961 2345 None 95 Human Binding pKi = 7.9 7.9 1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.5b01495
590 2345 None 95 Human Binding pKi = 7.9 7.9 1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.5b01495
CHEMBL191 2345 None 95 Human Binding pKi = 7.9 7.9 1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.5b01495
DB00678 2345 None 95 Human Binding pKi = 7.9 7.9 1 4
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.5b01495
9956392 101016 None 0 Rat Binding pKi = 7.9 7.9 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 463 6 2 6 5.8 Cc1cccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c12 10.1016/S0960-894X(01)81146-X
CHEMBL294500 101016 None 0 Rat Binding pKi = 7.9 7.9 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 463 6 2 6 5.8 Cc1cccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c12 10.1016/S0960-894X(01)81146-X
5311345 3019 None 46 Human Binding pKi = 7.9 7.9 -10 2
Inhibition of human AT1 receptorInhibition of human AT1 receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/acs.jmedchem.9b01780
597 3019 None 46 Human Binding pKi = 7.9 7.9 -10 2
Inhibition of human AT1 receptorInhibition of human AT1 receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/acs.jmedchem.9b01780
CHEMBL321820 3019 None 46 Human Binding pKi = 7.9 7.9 -10 2
Inhibition of human AT1 receptorInhibition of human AT1 receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/acs.jmedchem.9b01780
9978737 118890 None 1 Rat Binding pKi = 7.9 7.9 - 1
The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.
ChEMBL 407 10 3 5 4.3 CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1021/jm991050l
CHEMBL2111971 118890 None 1 Rat Binding pKi = 7.9 7.9 - 1
The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.
ChEMBL 407 10 3 5 4.3 CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1021/jm991050l
CHEMBL342261 118890 None 1 Rat Binding pKi = 7.9 7.9 - 1
The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.
ChEMBL 407 10 3 5 4.3 CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1021/jm991050l
CHEMBL1076630 208481 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
168289415 191312 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 527 8 1 9 4.8 CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL5191326 191312 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 527 8 1 9 4.8 CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
23298215 168074 None 0 Rat Binding pKi = 6.9 6.9 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 493 7 3 7 5.1 O=C(O)c1cccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c12 10.1016/S0960-894X(01)81146-X
CHEMBL432529 168074 None 0 Rat Binding pKi = 6.9 6.9 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 493 7 3 7 5.1 O=C(O)c1cccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c12 10.1016/S0960-894X(01)81146-X
44567849 189220 None 0 Pig Binding pKi = 6.9 6.9 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 488 11 1 5 5.2 CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
CHEMBL511490 189220 None 0 Pig Binding pKi = 6.9 6.9 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 488 11 1 5 5.2 CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
10048997 15499 None 0 Rat Binding pKi = 6.9 6.9 -14 2
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 442 9 2 6 4.7 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ccc1C(=O)O 10.1021/jm00098a018
CHEMBL121635 15499 None 0 Rat Binding pKi = 6.9 6.9 -14 2
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 442 9 2 6 4.7 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ccc1C(=O)O 10.1021/jm00098a018
155520317 170487 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 5 6.3 CCCCc1nc(Cl)c(CNC(=O)[C@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4449166 170487 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 5 6.3 CCCCc1nc(Cl)c(CNC(=O)[C@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
155523092 170812 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 5 6.1 CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4453362 170812 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 5 6.1 CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
87219128 172886 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 541 14 3 5 6.6 CCCCc1nc(Cl)c(CNC(=O)C(CS)CCCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4515703 172886 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 541 14 3 5 6.6 CCCCc1nc(Cl)c(CNC(=O)C(CS)CCCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
87218933 175080 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 555 14 3 5 6.9 CCCCc1nc(Cl)c(CNC(=O)C(CS)CCC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4568554 175080 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 555 14 3 5 6.9 CCCCc1nc(Cl)c(CNC(=O)C(CS)CCC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
10049001 205427 None 0 Rat Binding pKi = 6.9 6.9 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 442 6 2 8 4.1 CCCc1nc(C)n2c(S)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL80219 205427 None 0 Rat Binding pKi = 6.9 6.9 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 442 6 2 8 4.1 CCCc1nc(C)n2c(S)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
10697700 206899 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 539 11 1 5 4.8 CCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)C(=O)N2CCCC)cc1 10.1021/jm9904147
CHEMBL90872 206899 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 539 11 1 5 4.8 CCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)C(=O)N2CCCC)cc1 10.1021/jm9904147
44284308 14774 None 0 Rat Binding pKi = 7.9 7.9 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 617 12 1 10 6.4 CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL1206594 14774 None 0 Rat Binding pKi = 7.9 7.9 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 617 12 1 10 6.4 CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL2079769 14774 None 0 Rat Binding pKi = 7.9 7.9 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 617 12 1 10 6.4 CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL4299329 213612 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL4302429 213612 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
45488134 196975 None 0 Rat Binding pKi = 7.9 7.9 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 490 8 1 7 5.2 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(CCc2nnn[nH]2)cc1 10.1021/jm901272d
CHEMBL566614 196975 None 0 Rat Binding pKi = 7.9 7.9 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 490 8 1 7 5.2 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(CCc2nnn[nH]2)cc1 10.1021/jm901272d
1610 2345 None 95 Rat Binding pKi = 7.9 7.9 -1 4
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.03.028
3941 2345 None 95 Rat Binding pKi = 7.9 7.9 -1 4
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.03.028
3961 2345 None 95 Rat Binding pKi = 7.9 7.9 -1 4
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.03.028
590 2345 None 95 Rat Binding pKi = 7.9 7.9 -1 4
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.03.028
CHEMBL191 2345 None 95 Rat Binding pKi = 7.9 7.9 -1 4
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.03.028
DB00678 2345 None 95 Rat Binding pKi = 7.9 7.9 -1 4
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2016.03.028
23298206 100752 None 0 Rat Binding pKi = 5.9 5.9 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 463 6 2 6 5.8 Cc1cccc2c(C(=O)O)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C3CC3)nc12 10.1016/S0960-894X(01)81146-X
CHEMBL292792 100752 None 0 Rat Binding pKi = 5.9 5.9 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 463 6 2 6 5.8 Cc1cccc2c(C(=O)O)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C3CC3)nc12 10.1016/S0960-894X(01)81146-X
19029534 18561 None 0 Rat Binding pKi = 6.9 6.9 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 485 6 1 7 4.3 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(F)c2)s1 10.1016/S0960-894X(97)00026-7
CHEMBL127605 18561 None 0 Rat Binding pKi = 6.9 6.9 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 485 6 1 7 4.3 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(F)c2)s1 10.1016/S0960-894X(97)00026-7
10458763 204936 None 0 Rat Binding pKi = 6.9 6.9 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 503 8 2 9 2.7 CCCc1nc(C)n2nc(S(=O)(=O)NC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL76359 204936 None 0 Rat Binding pKi = 6.9 6.9 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 503 8 2 9 2.7 CCCc1nc(C)n2nc(S(=O)(=O)NC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
10095683 121510 None 0 Rat Binding pKi = 7.9 7.9 -1 2
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 458 7 1 5 4.4 CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL358359 121510 None 0 Rat Binding pKi = 7.9 7.9 -1 2
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 458 7 1 5 4.4 CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
10095683 121510 None 0 Human Binding pKi = 7.9 7.9 1 2
In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5
ChEMBL 458 7 1 5 4.4 CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm010457z
CHEMBL358359 121510 None 0 Human Binding pKi = 7.9 7.9 1 2
In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5
ChEMBL 458 7 1 5 4.4 CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm010457z
15480220 200732 None 0 Rat Binding pKi = 7.9 7.9 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 467 6 2 6 5.6 O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccc(F)cc12 10.1016/S0960-894X(01)81146-X
CHEMBL60010 200732 None 0 Rat Binding pKi = 7.9 7.9 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 467 6 2 6 5.6 O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccc(F)cc12 10.1016/S0960-894X(01)81146-X
1610 2345 None 95 Rat Binding pKi = 7.8 7.8 -1 4
Binding affinity against angiotensin II receptor from rat liver; n=8Binding affinity against angiotensin II receptor from rat liver; n=8
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00070a012
3941 2345 None 95 Rat Binding pKi = 7.8 7.8 -1 4
Binding affinity against angiotensin II receptor from rat liver; n=8Binding affinity against angiotensin II receptor from rat liver; n=8
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00070a012
3961 2345 None 95 Rat Binding pKi = 7.8 7.8 -1 4
Binding affinity against angiotensin II receptor from rat liver; n=8Binding affinity against angiotensin II receptor from rat liver; n=8
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00070a012
590 2345 None 95 Rat Binding pKi = 7.8 7.8 -1 4
Binding affinity against angiotensin II receptor from rat liver; n=8Binding affinity against angiotensin II receptor from rat liver; n=8
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00070a012
CHEMBL191 2345 None 95 Rat Binding pKi = 7.8 7.8 -1 4
Binding affinity against angiotensin II receptor from rat liver; n=8Binding affinity against angiotensin II receptor from rat liver; n=8
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00070a012
DB00678 2345 None 95 Rat Binding pKi = 7.8 7.8 -1 4
Binding affinity against angiotensin II receptor from rat liver; n=8Binding affinity against angiotensin II receptor from rat liver; n=8
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00070a012
1610 2345 None 95 Rat Binding pKi = 7.8 7.8 -1 4
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00098a018
3941 2345 None 95 Rat Binding pKi = 7.8 7.8 -1 4
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00098a018
3961 2345 None 95 Rat Binding pKi = 7.8 7.8 -1 4
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00098a018
590 2345 None 95 Rat Binding pKi = 7.8 7.8 -1 4
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00098a018
CHEMBL191 2345 None 95 Rat Binding pKi = 7.8 7.8 -1 4
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00098a018
DB00678 2345 None 95 Rat Binding pKi = 7.8 7.8 -1 4
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00098a018
44254496 5623 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [3H]valsartan from human recombinant AT1 receptor expressed in CHO cells after 40 mins by liquid scintillation countingDisplacement of [3H]valsartan from human recombinant AT1 receptor expressed in CHO cells after 40 mins by liquid scintillation counting
ChEMBL 770 18 7 8 2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm900651p
CHEMBL1077582 5623 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [3H]valsartan from human recombinant AT1 receptor expressed in CHO cells after 40 mins by liquid scintillation countingDisplacement of [3H]valsartan from human recombinant AT1 receptor expressed in CHO cells after 40 mins by liquid scintillation counting
ChEMBL 770 18 7 8 2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm900651p
19029594 18097 None 0 Rat Binding pKi = 6.9 6.9 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 512 7 1 9 4.1 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc([N+](=O)[O-])cc2)s1 10.1016/S0960-894X(97)00026-7
CHEMBL126801 18097 None 0 Rat Binding pKi = 6.9 6.9 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 512 7 1 9 4.1 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc([N+](=O)[O-])cc2)s1 10.1016/S0960-894X(97)00026-7
19029638 164209 None 0 Rat Binding pKi = 6.9 6.9 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 512 7 1 9 4.1 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc([N+](=O)[O-])c2)s1 10.1016/S0960-894X(97)00026-7
CHEMBL421092 164209 None 0 Rat Binding pKi = 6.9 6.9 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 512 7 1 9 4.1 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc([N+](=O)[O-])c2)s1 10.1016/S0960-894X(97)00026-7
10052744 14809 None 0 Rat Binding pKi = 5.8 5.8 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 530 10 1 5 7.2 CCCCC1=NC(Cl)=C(C(=O)OCC)C(c2ccccc2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
CHEMBL1207064 14809 None 0 Rat Binding pKi = 5.8 5.8 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 530 10 1 5 7.2 CCCCC1=NC(Cl)=C(C(=O)OCC)C(c2ccccc2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
CHEMBL343622 14809 None 0 Rat Binding pKi = 5.8 5.8 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 530 10 1 5 7.2 CCCCC1=NC(Cl)=C(C(=O)OCC)C(c2ccccc2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
44567819 183913 None 0 Pig Binding pKi = 6.8 6.8 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 488 11 1 5 5.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
CHEMBL481294 183913 None 0 Pig Binding pKi = 6.8 6.8 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 488 11 1 5 5.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
10005278 205188 None 0 Rat Binding pKi = 6.8 6.8 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 478 6 1 7 4.8 CCCc1nc(C)n2nc(C(F)(F)F)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL78399 205188 None 0 Rat Binding pKi = 6.8 6.8 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 478 6 1 7 4.8 CCCc1nc(C)n2nc(C(F)(F)F)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
10049622 104140 None 0 Rat Binding pKi = 7.8 7.8 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 454 8 1 8 4.0 CCCc1nc(C)n2nc(COC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL309458 104140 None 0 Rat Binding pKi = 7.8 7.8 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 454 8 1 8 4.0 CCCc1nc(C)n2nc(COC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
19029579 18502 None 0 Rat Binding pKi = 7.8 7.8 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 513 6 1 7 5.1 O=C(/N=c1\sc(C2CC2)nn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ccccc1Cl 10.1016/S0960-894X(97)00026-7
CHEMBL127332 18502 None 0 Rat Binding pKi = 7.8 7.8 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 513 6 1 7 5.1 O=C(/N=c1\sc(C2CC2)nn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ccccc1Cl 10.1016/S0960-894X(97)00026-7
10094936 16834 None 0 Rat Binding pKi = 7.8 7.8 -9 3
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 443 9 2 7 4.1 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O 10.1021/jm00070a012
CHEMBL1237156 16834 None 0 Rat Binding pKi = 7.8 7.8 -9 3
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 443 9 2 7 4.1 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O 10.1021/jm00070a012
CHEMBL124772 16834 None 0 Rat Binding pKi = 7.8 7.8 -9 3
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 443 9 2 7 4.1 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O 10.1021/jm00070a012
10094936 16834 None 0 Rat Binding pKi = 7.8 7.8 -9 3
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 443 9 2 7 4.1 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O 10.1021/jm00098a018
CHEMBL1237156 16834 None 0 Rat Binding pKi = 7.8 7.8 -9 3
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 443 9 2 7 4.1 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O 10.1021/jm00098a018
CHEMBL124772 16834 None 0 Rat Binding pKi = 7.8 7.8 -9 3
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 443 9 2 7 4.1 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O 10.1021/jm00098a018
44475015 171522 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 541 13 3 5 6.5 CCCCc1nc(Cl)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4464191 171522 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 541 13 3 5 6.5 CCCCc1nc(Cl)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
155557693 174666 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 599 13 3 7 6.2 CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4558883 174666 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 599 13 3 7 6.2 CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.8b00462
10003793 14682 None 0 Rat Binding pKi = 6.8 6.8 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 448 9 1 6 4.5 CCCCc1nc(C)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
CHEMBL1205758 14682 None 0 Rat Binding pKi = 6.8 6.8 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 448 9 1 6 4.5 CCCCc1nc(C)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
CHEMBL145276 14682 None 0 Rat Binding pKi = 6.8 6.8 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 448 9 1 6 4.5 CCCCc1nc(C)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
10504330 206812 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 464 5 1 5 4.4 O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)N(c2ccccc2)C(=O)C12CCCC2 10.1021/jm9904147
CHEMBL90411 206812 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 464 5 1 5 4.4 O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)N(c2ccccc2)C(=O)C12CCCC2 10.1021/jm9904147
155535176 172028 None 0 Human Binding pKi = 6.8 6.8 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 625 13 3 5 7.9 CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc3ccccc3c2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4471668 172028 None 0 Human Binding pKi = 6.8 6.8 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 625 13 3 5 7.9 CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc3ccccc3c2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
46935636 102570 None 0 Human Binding pKi = 5.8 5.8 -31622 2
Displacement of [tyrosyl-3,5-3H]angiotensin-2 from AT1 receptor (unknown origin) expressed in QBI-HEK293A cells after 2 hrsDisplacement of [tyrosyl-3,5-3H]angiotensin-2 from AT1 receptor (unknown origin) expressed in QBI-HEK293A cells after 2 hrs
ChEMBL 524 7 1 6 5.9 O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 10.1016/j.bmc.2013.09.004
CHEMBL2440460 102570 None 0 Human Binding pKi = 5.8 5.8 -31622 2
Displacement of [tyrosyl-3,5-3H]angiotensin-2 from AT1 receptor (unknown origin) expressed in QBI-HEK293A cells after 2 hrsDisplacement of [tyrosyl-3,5-3H]angiotensin-2 from AT1 receptor (unknown origin) expressed in QBI-HEK293A cells after 2 hrs
ChEMBL 524 7 1 6 5.9 O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 10.1016/j.bmc.2013.09.004
CHEMBL3040772 102570 None 0 Human Binding pKi = 5.8 5.8 -31622 2
Displacement of [tyrosyl-3,5-3H]angiotensin-2 from AT1 receptor (unknown origin) expressed in QBI-HEK293A cells after 2 hrsDisplacement of [tyrosyl-3,5-3H]angiotensin-2 from AT1 receptor (unknown origin) expressed in QBI-HEK293A cells after 2 hrs
ChEMBL 524 7 1 6 5.9 O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 10.1016/j.bmc.2013.09.004
CHEMBL5271135 193669 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 391 4 1 4 4.6 Cc1ccc(S(=O)(=O)n2c(-c3ccccc3)c(C(=O)O)c3ccccc32)cc1 10.1016/j.bmcl.2023.129349
10391609 14680 None 0 Rat Binding pKi = 5.8 5.8 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 510 10 1 6 5.8 CCCCc1nc(-c2ccccc2)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
CHEMBL1205753 14680 None 0 Rat Binding pKi = 5.8 5.8 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 510 10 1 6 5.8 CCCCc1nc(-c2ccccc2)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
CHEMBL144952 14680 None 0 Rat Binding pKi = 5.8 5.8 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 510 10 1 6 5.8 CCCCc1nc(-c2ccccc2)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
45488167 197152 None 0 Rat Binding pKi = 5.8 5.8 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 520 10 1 8 5.2 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CCc2nnn[nH]2)cc1 10.1021/jm901272d
CHEMBL567898 197152 None 0 Rat Binding pKi = 5.8 5.8 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 520 10 1 8 5.2 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CCc2nnn[nH]2)cc1 10.1021/jm901272d
44567850 183961 None 0 Pig Binding pKi = 6.8 6.8 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 522 11 1 5 5.6 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
CHEMBL481664 183961 None 0 Pig Binding pKi = 6.8 6.8 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 522 11 1 5 5.6 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
1610 2345 None 95 Human Binding pKi = 7.8 7.8 1 4
Displacement of [3H]-Angiotensin 2 from AT1 receptor in human PLC/PRF/5 cells after 20 mins by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from AT1 receptor in human PLC/PRF/5 cells after 20 mins by liquid scintillation counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.5b01495
3941 2345 None 95 Human Binding pKi = 7.8 7.8 1 4
Displacement of [3H]-Angiotensin 2 from AT1 receptor in human PLC/PRF/5 cells after 20 mins by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from AT1 receptor in human PLC/PRF/5 cells after 20 mins by liquid scintillation counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.5b01495
3961 2345 None 95 Human Binding pKi = 7.8 7.8 1 4
Displacement of [3H]-Angiotensin 2 from AT1 receptor in human PLC/PRF/5 cells after 20 mins by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from AT1 receptor in human PLC/PRF/5 cells after 20 mins by liquid scintillation counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.5b01495
590 2345 None 95 Human Binding pKi = 7.8 7.8 1 4
Displacement of [3H]-Angiotensin 2 from AT1 receptor in human PLC/PRF/5 cells after 20 mins by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from AT1 receptor in human PLC/PRF/5 cells after 20 mins by liquid scintillation counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.5b01495
CHEMBL191 2345 None 95 Human Binding pKi = 7.8 7.8 1 4
Displacement of [3H]-Angiotensin 2 from AT1 receptor in human PLC/PRF/5 cells after 20 mins by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from AT1 receptor in human PLC/PRF/5 cells after 20 mins by liquid scintillation counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.5b01495
DB00678 2345 None 95 Human Binding pKi = 7.8 7.8 1 4
Displacement of [3H]-Angiotensin 2 from AT1 receptor in human PLC/PRF/5 cells after 20 mins by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from AT1 receptor in human PLC/PRF/5 cells after 20 mins by liquid scintillation counting
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acs.jmedchem.5b01495
19029509 18066 None 0 Rat Binding pKi = 7.8 7.8 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 487 5 1 7 4.5 Cc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 10.1016/S0960-894X(97)00026-7
CHEMBL126643 18066 None 0 Rat Binding pKi = 7.8 7.8 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 487 5 1 7 4.5 Cc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 10.1016/S0960-894X(97)00026-7
123794 892 None 46 Rat Binding pKi = 5.8 5.8 -67608 2
Displacement of [125I]Ang II from AT1 receptor in rat SMC membranes incubated for 60 mins by gamma counting methodDisplacement of [125I]Ang II from AT1 receptor in rat SMC membranes incubated for 60 mins by gamma counting method
ChEMBL None None None None 10.1021/acs.jmedchem.9b01780
3944 892 None 46 Rat Binding pKi = 5.8 5.8 -67608 2
Displacement of [125I]Ang II from AT1 receptor in rat SMC membranes incubated for 60 mins by gamma counting methodDisplacement of [125I]Ang II from AT1 receptor in rat SMC membranes incubated for 60 mins by gamma counting method
ChEMBL None None None None 10.1021/acs.jmedchem.9b01780
594 892 None 46 Rat Binding pKi = 5.8 5.8 -67608 2
Displacement of [125I]Ang II from AT1 receptor in rat SMC membranes incubated for 60 mins by gamma counting methodDisplacement of [125I]Ang II from AT1 receptor in rat SMC membranes incubated for 60 mins by gamma counting method
ChEMBL None None None None 10.1021/acs.jmedchem.9b01780
CHEMBL1885579 892 None 46 Rat Binding pKi = 5.8 5.8 -67608 2
Displacement of [125I]Ang II from AT1 receptor in rat SMC membranes incubated for 60 mins by gamma counting methodDisplacement of [125I]Ang II from AT1 receptor in rat SMC membranes incubated for 60 mins by gamma counting method
ChEMBL None None None None 10.1021/acs.jmedchem.9b01780
10004228 205013 None 0 Rat Binding pKi = 6.8 6.8 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 456 7 1 8 4.5 CCCc1nc(C)n2nc(SC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL76866 205013 None 0 Rat Binding pKi = 6.8 6.8 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 456 7 1 8 4.5 CCCc1nc(C)n2nc(SC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
10005644 205518 None 0 Rat Binding pKi = 6.8 6.8 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 486 7 1 7 5.5 CCCc1nc(C)n2nc(-c3ccccc3)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL80854 205518 None 0 Rat Binding pKi = 6.8 6.8 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 486 7 1 7 5.5 CCCc1nc(C)n2nc(-c3ccccc3)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL1076601 208474 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
168294859 192274 None 0 Human Binding pKi = 6.8 6.8 -19 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 13 1 6 7.3 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5205769 192274 None 0 Human Binding pKi = 6.8 6.8 -19 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 13 1 6 7.3 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10029566 205075 None 0 Rat Binding pKi = 6.7 6.7 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 517 8 1 9 3.1 CCCc1nc(C)n2nc(S(=O)(=O)N(C)C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL77384 205075 None 0 Rat Binding pKi = 6.7 6.7 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 517 8 1 9 3.1 CCCc1nc(C)n2nc(S(=O)(=O)N(C)C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
59984617 85275 None 0 Rat Binding pKi = 6.7 6.7 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
ChEMBL 558 8 2 6 7.0 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)O)cc2C(=O)O)cc1 10.1007/s00044-008-9153-9
CHEMBL2260199 85275 None 0 Rat Binding pKi = 6.7 6.7 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
ChEMBL 558 8 2 6 7.0 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)O)cc2C(=O)O)cc1 10.1007/s00044-008-9153-9
CHEMBL1076612 208478 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C(=O)c2ccccc2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
87218987 171005 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 523 13 3 6 5.6 CCCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4456519 171005 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 523 13 3 6 5.6 CCCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
10415026 165671 None 0 Rat Binding pKi = 6.7 6.7 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 544 10 1 5 7.5 CCCCC1=NC(c2ccc(Cl)cc2)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
CHEMBL424483 165671 None 0 Rat Binding pKi = 6.7 6.7 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 544 10 1 5 7.5 CCCCC1=NC(c2ccc(Cl)cc2)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
19029491 116962 None 0 Rat Binding pKi = 6.7 6.7 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 501 6 1 7 4.8 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(Cl)c2)s1 10.1016/S0960-894X(97)00026-7
CHEMBL338670 116962 None 0 Rat Binding pKi = 6.7 6.7 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 501 6 1 7 4.8 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(Cl)c2)s1 10.1016/S0960-894X(97)00026-7
10365342 113493 None 0 Rat Binding pKi = 6.7 6.7 -16 2
Compound was evaluated for binding affinity against AT1 receptor in rat liverCompound was evaluated for binding affinity against AT1 receptor in rat liver
ChEMBL 429 9 3 7 4.0 CCCCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1021/jm00098a018
CHEMBL331983 113493 None 0 Rat Binding pKi = 6.7 6.7 -16 2
Compound was evaluated for binding affinity against AT1 receptor in rat liverCompound was evaluated for binding affinity against AT1 receptor in rat liver
ChEMBL 429 9 3 7 4.0 CCCCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1021/jm00098a018
155516694 170111 None 0 Human Binding pKi = 6.7 6.7 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 507 12 3 5 5.9 CCCCc1nc(C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4443691 170111 None 0 Human Binding pKi = 6.7 6.7 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 507 12 3 5 5.9 CCCCc1nc(C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
19029483 18826 None 0 Rat Binding pKi = 6.7 6.7 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 529 8 1 7 5.6 CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 10.1016/S0960-894X(97)00026-7
CHEMBL128003 18826 None 0 Rat Binding pKi = 6.7 6.7 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 529 8 1 7 5.6 CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 10.1016/S0960-894X(97)00026-7
10790260 206775 None 0 Human Binding pKi = 5.7 5.7 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 463 8 2 4 4.1 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)Nc2ccccc2C(=O)O)cc1 10.1021/jm9904147
CHEMBL90187 206775 None 0 Human Binding pKi = 5.7 5.7 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 463 8 2 4 4.1 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)Nc2ccccc2C(=O)O)cc1 10.1021/jm9904147
1481 2064 None 116 Human Binding pKi = 8.7 8.7 1 3
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm9904147
3749 2064 None 116 Human Binding pKi = 8.7 8.7 1 3
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm9904147
589 2064 None 116 Human Binding pKi = 8.7 8.7 1 3
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm9904147
6908 2064 None 116 Human Binding pKi = 8.7 8.7 1 3
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm9904147
CHEMBL1513 2064 None 116 Human Binding pKi = 8.7 8.7 1 3
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm9904147
DB01029 2064 None 116 Human Binding pKi = 8.7 8.7 1 3
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm9904147
135723840 139140 None 0 Rat Binding pKi = 8.7 8.7 - 1
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 452 8 2 6 4.6 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmc.2016.03.028
CHEMBL3787059 139140 None 0 Rat Binding pKi = 8.7 8.7 - 1
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 452 8 2 6 4.6 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmc.2016.03.028
3936 2208 None 35 Pig Binding pKi = 8.7 8.7 -1 4
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2008.05.066
6603900 2208 None 35 Pig Binding pKi = 8.7 8.7 -1 4
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2008.05.066
CHEMBL288174 2208 None 35 Pig Binding pKi = 8.7 8.7 -1 4
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2008.05.066
1481 2064 None 116 Human Binding pKi = 8.7 8.7 1 3
In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm010457z
3749 2064 None 116 Human Binding pKi = 8.7 8.7 1 3
In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm010457z
589 2064 None 116 Human Binding pKi = 8.7 8.7 1 3
In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm010457z
6908 2064 None 116 Human Binding pKi = 8.7 8.7 1 3
In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm010457z
CHEMBL1513 2064 None 116 Human Binding pKi = 8.7 8.7 1 3
In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm010457z
DB01029 2064 None 116 Human Binding pKi = 8.7 8.7 1 3
In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm010457z
44350610 118164 None 0 Rat Binding pKi = 8.7 8.7 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 525 8 2 8 4.2 CCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 10.1016/S0960-894X(97)00026-7
CHEMBL340863 118164 None 0 Rat Binding pKi = 8.7 8.7 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 525 8 2 8 4.2 CCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 10.1016/S0960-894X(97)00026-7
10005741 111448 None 0 Human Binding pKi = 8.7 8.7 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 488 7 2 7 4.5 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 10.1021/jm00014a024
CHEMBL327535 111448 None 0 Human Binding pKi = 8.7 8.7 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 488 7 2 7 4.5 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 10.1021/jm00014a024
10031067 100350 None 4 Rat Binding pKi = 8.7 8.7 -2 3
Displacement of [125]Ang2 from AT1 receptor in rat liver membraneDisplacement of [125]Ang2 from AT1 receptor in rat liver membrane
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2008.05.066
CHEMBL289614 100350 None 4 Rat Binding pKi = 8.7 8.7 -2 3
Displacement of [125]Ang2 from AT1 receptor in rat liver membraneDisplacement of [125]Ang2 from AT1 receptor in rat liver membrane
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2008.05.066
127029976 139215 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786145 139215 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787767 139215 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
23298214 102010 None 0 Rat Binding pKi = 8.7 8.7 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 450 6 2 7 4.8 O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2cccnc12 10.1016/S0960-894X(01)81146-X
CHEMBL301689 102010 None 0 Rat Binding pKi = 8.7 8.7 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 450 6 2 7 4.8 O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2cccnc12 10.1016/S0960-894X(01)81146-X
19029671 118085 None 0 Rat Binding pKi = 8.6 8.6 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 497 7 1 8 4.2 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2OC)s1 10.1016/S0960-894X(97)00026-7
CHEMBL340618 118085 None 0 Rat Binding pKi = 8.6 8.6 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 497 7 1 8 4.2 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2OC)s1 10.1016/S0960-894X(97)00026-7
10745817 119373 None 0 Rat Binding pKi = 8.6 8.6 - 1
The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.
ChEMBL 580 12 3 7 5.4 CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 10.1021/jm991050l
CHEMBL2111973 119373 None 0 Rat Binding pKi = 8.6 8.6 - 1
The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.
ChEMBL 580 12 3 7 5.4 CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 10.1021/jm991050l
CHEMBL344464 119373 None 0 Rat Binding pKi = 8.6 8.6 - 1
The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.
ChEMBL 580 12 3 7 5.4 CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 10.1021/jm991050l
87219174 169763 None 0 Human Binding pKi = 8.6 8.6 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 537 14 3 6 5.9 CCCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4438878 169763 None 0 Human Binding pKi = 8.6 8.6 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 537 14 3 6 5.9 CCCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
44567745 183883 None 0 Pig Binding pKi = 8.6 8.6 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 480 10 2 6 5.0 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC(C)C)cc1 10.1016/j.bmc.2008.05.066
CHEMBL481089 183883 None 0 Pig Binding pKi = 8.6 8.6 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 480 10 2 6 5.0 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC(C)C)cc1 10.1016/j.bmc.2008.05.066
44350616 18825 None 0 Rat Binding pKi = 8.6 8.6 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 497 6 2 8 3.6 Cc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 10.1016/S0960-894X(97)00026-7
CHEMBL127988 18825 None 0 Rat Binding pKi = 8.6 8.6 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 497 6 2 8 3.6 Cc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 10.1016/S0960-894X(97)00026-7
10345537 111600 None 0 Human Binding pKi = 8.6 8.6 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 492 6 2 8 4.0 CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 10.1021/jm00014a024
CHEMBL328296 111600 None 0 Human Binding pKi = 8.6 8.6 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 492 6 2 8 4.0 CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 10.1021/jm00014a024
10481196 112744 None 0 Human Binding pKi = 8.6 8.6 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 503 6 2 7 4.9 CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2cc(C(=O)O)ccc2n1 10.1021/jm00014a024
CHEMBL330508 112744 None 0 Human Binding pKi = 8.6 8.6 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 503 6 2 7 4.9 CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2cc(C(=O)O)ccc2n1 10.1021/jm00014a024
10432780 164510 None 0 Rat Binding pKi = 8.6 8.6 -10 3
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 429 8 2 7 3.7 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O 10.1021/jm00070a012
CHEMBL421473 164510 None 0 Rat Binding pKi = 8.6 8.6 -10 3
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 429 8 2 7 3.7 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O 10.1021/jm00070a012
10432780 164510 None 0 Rat Binding pKi = 8.6 8.6 -10 3
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 429 8 2 7 3.7 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O 10.1021/jm00098a018
CHEMBL421473 164510 None 0 Rat Binding pKi = 8.6 8.6 -10 3
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 429 8 2 7 3.7 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O 10.1021/jm00098a018
127029977 139216 None 0 Human Binding pKi = 8.6 8.6 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786986 139216 None 0 Human Binding pKi = 8.6 8.6 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787768 139216 None 0 Human Binding pKi = 8.6 8.6 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
44325313 207438 None 0 Human Binding pKi = 8.5 8.5 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 480 6 2 8 4.3 CCOC(=O)c1c(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C 10.1021/jm00014a024
CHEMBL94106 207438 None 0 Human Binding pKi = 8.5 8.5 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 480 6 2 8 4.3 CCOC(=O)c1c(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C 10.1021/jm00014a024
127866 102803 None 17 Rat Binding pKi = 8.5 8.5 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 449 6 2 6 5.5 O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccccc12 10.1016/S0960-894X(01)81146-X
CHEMBL305365 102803 None 17 Rat Binding pKi = 8.5 8.5 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 449 6 2 6 5.5 O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccccc12 10.1016/S0960-894X(01)81146-X
127866 102803 None 17 Rat Binding pKi = 8.5 8.5 - 1
Receptor binding affinity determined from competitive binding assay using 1251 labelled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesReceptor binding affinity determined from competitive binding assay using 1251 labelled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 449 6 2 6 5.5 O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccccc12 10.1016/S0960-894X(01)81147-1
CHEMBL305365 102803 None 17 Rat Binding pKi = 8.5 8.5 - 1
Receptor binding affinity determined from competitive binding assay using 1251 labelled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesReceptor binding affinity determined from competitive binding assay using 1251 labelled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 449 6 2 6 5.5 O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccccc12 10.1016/S0960-894X(01)81147-1
132404 119784 None 14 Human Binding pKi = 7.7 7.7 36 2
Ki value was evaluated against Angiotensin II receptor, type 1Ki value was evaluated against Angiotensin II receptor, type 1
ChEMBL 637 13 3 5 8.0 CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 10.1021/jm9504722
CHEMBL348126 119784 None 14 Human Binding pKi = 7.7 7.7 36 2
Ki value was evaluated against Angiotensin II receptor, type 1Ki value was evaluated against Angiotensin II receptor, type 1
ChEMBL 637 13 3 5 8.0 CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 10.1021/jm9504722
15658054 206724 None 0 Rat Binding pKi = 7.7 7.7 - 1
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 429 8 2 8 3.7 CCOC(=O)c1cnc(CC)nc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00070a012
CHEMBL89877 206724 None 0 Rat Binding pKi = 7.7 7.7 - 1
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 429 8 2 8 3.7 CCOC(=O)c1cnc(CC)nc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00070a012
CHEMBL5273768 193774 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 455 7 1 5 5.0 O=C(O)c1c(COCc2ccccc2)n(-c2ccc(S(=O)(=O)Cl)cc2)c2ccccc12 10.1016/j.bmcl.2023.129349
CHEMBL5271903 193700 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 321 5 1 3 4.4 CCCCc1c(C(=O)O)c2ccccc2n1C(=O)c1ccccc1 10.1016/j.bmcl.2023.129349
19029687 19371 None 0 Rat Binding pKi = 7.7 7.7 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 515 7 1 7 5.2 CCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 10.1016/S0960-894X(97)00026-7
CHEMBL129181 19371 None 0 Rat Binding pKi = 7.7 7.7 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 515 7 1 7 5.2 CCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 10.1016/S0960-894X(97)00026-7
11744384 32345 None 0 Rat Binding pKi = 7.7 7.7 - 1
The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.
ChEMBL 448 11 3 6 5.2 CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1021/jm991050l
CHEMBL141065 32345 None 0 Rat Binding pKi = 7.7 7.7 - 1
The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.
ChEMBL 448 11 3 6 5.2 CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1021/jm991050l
CHEMBL2111972 32345 None 0 Rat Binding pKi = 7.7 7.7 - 1
The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.The compound was evaluated for the inhibition of [125I]-Sar-AII binding to Angiotensin II receptor, type 1 from purified rat liver membranes.
ChEMBL 448 11 3 6 5.2 CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 10.1021/jm991050l
45488164 197829 None 0 Rat Binding pKi = 5.7 5.7 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 602 12 1 7 7.4 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)O)cc1 10.1021/jm901272d
CHEMBL572276 197829 None 0 Rat Binding pKi = 5.7 5.7 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 602 12 1 7 7.4 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)O)cc1 10.1021/jm901272d
118719137 115443 None 0 Human Binding pKi = 5.7 5.7 -4 2
Displacement of [125I]-angiotensin 2 from human angiotensin 2 type-1 receptor expressed in CHO cell membranes after 1 hr by gamma counting analysisDisplacement of [125I]-angiotensin 2 from human angiotensin 2 type-1 receptor expressed in CHO cell membranes after 1 hr by gamma counting analysis
ChEMBL 1405 38 7 16 7.6 CCN(CC)c1ccc2c(-c3ccc(S(=O)(=O)NCCCCCCCCCCCCNC(=O)NCCCC[C@H](NC(=O)Cc4csc(=N)n4C)C(=O)N[C@@H](Cc4cn(Cc5ccccc5)c[n+]4C)C(=O)NC4CCN(C)CC4)cc3S(=O)(=O)[O-])c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/jm401789v
CHEMBL3234445 115443 None 0 Human Binding pKi = 5.7 5.7 -4 2
Displacement of [125I]-angiotensin 2 from human angiotensin 2 type-1 receptor expressed in CHO cell membranes after 1 hr by gamma counting analysisDisplacement of [125I]-angiotensin 2 from human angiotensin 2 type-1 receptor expressed in CHO cell membranes after 1 hr by gamma counting analysis
ChEMBL 1405 38 7 16 7.6 CCN(CC)c1ccc2c(-c3ccc(S(=O)(=O)NCCCCCCCCCCCCNC(=O)NCCCC[C@H](NC(=O)Cc4csc(=N)n4C)C(=O)N[C@@H](Cc4cn(Cc5ccccc5)c[n+]4C)C(=O)NC4CCN(C)CC4)cc3S(=O)(=O)[O-])c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/jm401789v
CHEMBL3350781 115443 None 0 Human Binding pKi = 5.7 5.7 -4 2
Displacement of [125I]-angiotensin 2 from human angiotensin 2 type-1 receptor expressed in CHO cell membranes after 1 hr by gamma counting analysisDisplacement of [125I]-angiotensin 2 from human angiotensin 2 type-1 receptor expressed in CHO cell membranes after 1 hr by gamma counting analysis
ChEMBL 1405 38 7 16 7.6 CCN(CC)c1ccc2c(-c3ccc(S(=O)(=O)NCCCCCCCCCCCCNC(=O)NCCCC[C@H](NC(=O)Cc4csc(=N)n4C)C(=O)N[C@@H](Cc4cn(Cc5ccccc5)c[n+]4C)C(=O)NC4CCN(C)CC4)cc3S(=O)(=O)[O-])c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/jm401789v
10252692 205182 None 0 Rat Binding pKi = 6.7 6.7 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 440 7 2 8 3.8 CCCc1nc(CC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL78342 205182 None 0 Rat Binding pKi = 6.7 6.7 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 440 7 2 8 3.8 CCCc1nc(CC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
10050933 205498 None 0 Rat Binding pKi = 7.6 7.6 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 482 8 1 9 4.0 CCCc1nc(C)n2nc(C(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL80688 205498 None 0 Rat Binding pKi = 7.6 7.6 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 482 8 1 9 4.0 CCCc1nc(C)n2nc(C(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL5282200 194147 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 345 4 2 5 2.4 Cc1ccc(S(=O)(=O)n2c(CO)c(C(=O)O)c3ccccc32)cc1 10.1016/j.bmcl.2023.129349
132840 105487 None 22 Human Binding pKi = 7.6 7.6 1 3
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 426 6 2 8 3.5 CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL312104 105487 None 22 Human Binding pKi = 7.6 7.6 1 3
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 426 6 2 8 3.5 CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
132840 105487 None 22 Rat Binding pKi = 7.6 7.6 -1 3
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 426 6 2 8 3.5 CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL312104 105487 None 22 Rat Binding pKi = 7.6 7.6 -1 3
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 426 6 2 8 3.5 CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL5277518 193934 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 359 6 1 5 2.9 CS(=O)(=O)n1c(COCc2ccccc2)c(C(=O)O)c2ccccc21 10.1016/j.bmcl.2023.129349
CHEMBL1076602 208475 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
145957579 162309 None 0 Human Binding pKi = 4.6 4.6 - 1
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 497 7 0 3 7.0 CCCCC1=N/C(=C\c2ccc(Br)cc2)C(=O)N1Cc1ccc(-c2ccccc2C#N)cc1 10.1016/j.ejmech.2017.12.021
CHEMBL4164514 162309 None 0 Human Binding pKi = 4.6 4.6 - 1
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 497 7 0 3 7.0 CCCCC1=N/C(=C\c2ccc(Br)cc2)C(=O)N1Cc1ccc(-c2ccccc2C#N)cc1 10.1016/j.ejmech.2017.12.021
5249743 107023 None 1 Human Binding pKi = 7.6 7.6 1 2
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 444 7 1 5 4.0 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9904147
CHEMBL315444 107023 None 1 Human Binding pKi = 7.6 7.6 1 2
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 444 7 1 5 4.0 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9904147
10674630 206830 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 573 10 1 5 5.3 CCCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9904147
CHEMBL90483 206830 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 573 10 1 5 5.3 CCCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9904147
11577472 14610 None 0 Rat Binding pKi = 7.6 7.6 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 503 9 1 8 5.2 CCCCc1nc(Cl)c(C(=O)OCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL1204970 14610 None 0 Rat Binding pKi = 7.6 7.6 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 503 9 1 8 5.2 CCCCc1nc(Cl)c(C(=O)OCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL2021416 14610 None 0 Rat Binding pKi = 7.6 7.6 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 503 9 1 8 5.2 CCCCc1nc(Cl)c(C(=O)OCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
5249743 107023 None 1 Rat Binding pKi = 7.6 7.6 -1 2
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 444 7 1 5 4.0 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL315444 107023 None 1 Rat Binding pKi = 7.6 7.6 -1 2
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 444 7 1 5 4.0 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
53317942 57596 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [3H]-angiotensin 2 from angiotensin AT1 receptor in human PLC-PRF5 cellsDisplacement of [3H]-angiotensin 2 from angiotensin AT1 receptor in human PLC-PRF5 cells
ChEMBL 444 7 1 7 3.3 CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O 10.1016/j.bmc.2010.10.043
CHEMBL1667999 57596 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [3H]-angiotensin 2 from angiotensin AT1 receptor in human PLC-PRF5 cellsDisplacement of [3H]-angiotensin 2 from angiotensin AT1 receptor in human PLC-PRF5 cells
ChEMBL 444 7 1 7 3.3 CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O 10.1016/j.bmc.2010.10.043
1610 2345 None 95 Rat Binding pKi = 7.6 7.6 -1 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm011063a
3941 2345 None 95 Rat Binding pKi = 7.6 7.6 -1 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm011063a
3961 2345 None 95 Rat Binding pKi = 7.6 7.6 -1 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm011063a
590 2345 None 95 Rat Binding pKi = 7.6 7.6 -1 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm011063a
CHEMBL191 2345 None 95 Rat Binding pKi = 7.6 7.6 -1 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm011063a
DB00678 2345 None 95 Rat Binding pKi = 7.6 7.6 -1 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm011063a
5249743 107023 None 1 Human Binding pKi = 7.6 7.6 1 2
In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5
ChEMBL 444 7 1 5 4.0 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm010457z
CHEMBL315444 107023 None 1 Human Binding pKi = 7.6 7.6 1 2
In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5
ChEMBL 444 7 1 5 4.0 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm010457z
87218826 172095 None 0 Human Binding pKi = 6.6 6.6 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 581 13 3 5 7.4 CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4472489 172095 None 0 Human Binding pKi = 6.6 6.6 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 581 13 3 5 7.4 CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
45488163 197765 None 0 Rat Binding pKi = 5.6 5.6 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 630 13 0 8 7.9 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)OCC)cc1 10.1021/jm901272d
CHEMBL571763 197765 None 0 Rat Binding pKi = 5.6 5.6 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 630 13 0 8 7.9 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)OCC)cc1 10.1021/jm901272d
163409136 190900 None 3 Human Binding pKi = 7.6 7.6 18 2
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 583 11 1 9 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
CHEMBL5185088 190900 None 3 Human Binding pKi = 7.6 7.6 18 2
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 583 11 1 9 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
CHEMBL5289070 194454 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 269 3 2 5 0.6 CS(=O)(=O)n1c(CO)c(C(=O)O)c2ccccc21 10.1016/j.bmcl.2023.129349
CHEMBL1076613 208479 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from wild-type human AT1 receptor expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
10433378 204915 None 0 Rat Binding pKi = 7.6 7.6 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 440 7 2 8 3.3 CCCc1nc(CO)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL76149 204915 None 0 Rat Binding pKi = 7.6 7.6 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 440 7 2 8 3.3 CCCc1nc(CO)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
10071944 205015 None 0 Rat Binding pKi = 7.6 7.6 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 440 7 1 8 3.8 CCCc1nc(C)n2nc(OC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL76900 205015 None 0 Rat Binding pKi = 7.6 7.6 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 440 7 1 8 3.8 CCCc1nc(C)n2nc(OC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL5275739 193868 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 371 6 1 4 4.2 CCCCc1c(C(=O)O)c2ccccc2n1S(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2023.129349
19029650 20238 None 0 Rat Binding pKi = 7.6 7.6 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 497 7 1 8 4.2 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(OC)cc2)s1 10.1016/S0960-894X(97)00026-7
CHEMBL130530 20238 None 0 Rat Binding pKi = 7.6 7.6 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 497 7 1 8 4.2 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(OC)cc2)s1 10.1016/S0960-894X(97)00026-7
168295859 192283 None 0 Human Binding pKi = 7.6 7.6 50 2
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 569 11 1 9 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
CHEMBL5205969 192283 None 0 Human Binding pKi = 7.6 7.6 50 2
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 569 11 1 9 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
CHEMBL5287876 194397 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 295 5 1 4 2.5 CCCCc1c(C(=O)O)c2ccccc2n1S(C)(=O)=O 10.1016/j.bmcl.2023.129349
45488125 197151 None 0 Rat Binding pKi = 5.6 5.6 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 360 7 1 5 3.6 CCCc1nc2c(C)cccc2n1Cc1ccc(CCc2nnn[nH]2)cc1 10.1021/jm901272d
CHEMBL567897 197151 None 0 Rat Binding pKi = 5.6 5.6 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 360 7 1 5 3.6 CCCc1nc2c(C)cccc2n1Cc1ccc(CCc2nnn[nH]2)cc1 10.1021/jm901272d
10742620 57600 None 0 Human Binding pKi = 7.5 7.5 16 2
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 460 7 2 6 5.1 CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1668003 57600 None 0 Human Binding pKi = 7.5 7.5 16 2
Binding affinity to angiotensin AT1 receptorBinding affinity to angiotensin AT1 receptor
ChEMBL 460 7 2 6 5.1 CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
131590 20701 None 44 Human Binding pKi = 7.5 7.5 1 3
Ki value was evaluated against Angiotensin II receptor, type 1Ki value was evaluated against Angiotensin II receptor, type 1
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm9504722
CHEMBL130896 20701 None 44 Human Binding pKi = 7.5 7.5 1 3
Ki value was evaluated against Angiotensin II receptor, type 1Ki value was evaluated against Angiotensin II receptor, type 1
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm9504722
131590 20701 None 44 Rabbit Binding pKi = 7.5 7.5 -1 3
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00052a006
CHEMBL130896 20701 None 44 Rabbit Binding pKi = 7.5 7.5 -1 3
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00052a006
44567851 183803 None 0 Pig Binding pKi = 6.5 6.5 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 522 11 1 5 5.6 CCCCOC(=O)NS(=O)(=O)c1cc(Cc2ccccc2)ccc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
CHEMBL480506 183803 None 0 Pig Binding pKi = 6.5 6.5 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 522 11 1 5 5.6 CCCCOC(=O)NS(=O)(=O)c1cc(Cc2ccccc2)ccc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
19029656 118465 None 0 Rat Binding pKi = 6.5 6.5 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 545 6 1 7 4.9 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(Br)c2)s1 10.1016/S0960-894X(97)00026-7
CHEMBL341292 118465 None 0 Rat Binding pKi = 6.5 6.5 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 545 6 1 7 4.9 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(Br)c2)s1 10.1016/S0960-894X(97)00026-7
2806 3967 None 110 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1016/j.ejmech.2017.12.021
3937 3967 None 110 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1016/j.ejmech.2017.12.021
593 3967 None 110 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1016/j.ejmech.2017.12.021
60846 3967 None 110 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1016/j.ejmech.2017.12.021
CHEMBL1069 3967 None 110 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1016/j.ejmech.2017.12.021
DB00177 3967 None 110 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1016/j.ejmech.2017.12.021
25141238 192543 None 0 Pig Binding pKi = 8.5 8.5 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 494 11 1 6 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
CHEMBL521093 192543 None 0 Pig Binding pKi = 8.5 8.5 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 494 11 1 6 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
127031545 139194 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787379 139194 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787701 139194 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
192314 114498 None 28 Rat Binding pKi = 8.5 8.5 -26 3
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 429 9 2 7 3.8 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O 10.1021/jm00098a018
CHEMBL1237157 114498 None 28 Rat Binding pKi = 8.5 8.5 -26 3
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 429 9 2 7 3.8 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O 10.1021/jm00098a018
CHEMBL333534 114498 None 28 Rat Binding pKi = 8.5 8.5 -26 3
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverCompound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
ChEMBL 429 9 2 7 3.8 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O 10.1021/jm00098a018
136093942 139092 None 0 Rat Binding pKi = 8.5 8.5 - 1
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 436 8 1 6 4.8 CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmc.2016.03.028
CHEMBL3786570 139092 None 0 Rat Binding pKi = 8.5 8.5 - 1
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 436 8 1 6 4.8 CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmc.2016.03.028
44567817 183037 None 0 Pig Binding pKi = 8.5 8.5 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 506 9 1 6 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCCC2)cc1 10.1016/j.bmc.2008.05.066
CHEMBL479399 183037 None 0 Pig Binding pKi = 8.5 8.5 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 506 9 1 6 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCCC2)cc1 10.1016/j.bmc.2008.05.066
23298216 163177 None 0 Rat Binding pKi = 8.5 8.5 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 423 5 2 6 4.9 Cc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81146-X
CHEMBL418122 163177 None 0 Rat Binding pKi = 8.5 8.5 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 423 5 2 6 4.9 Cc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81146-X
19029654 18341 None 0 Rat Binding pKi = 8.5 8.5 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 512 7 1 9 4.1 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2[N+](=O)[O-])s1 10.1016/S0960-894X(97)00026-7
CHEMBL127090 18341 None 0 Rat Binding pKi = 8.5 8.5 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 512 7 1 9 4.1 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2[N+](=O)[O-])s1 10.1016/S0960-894X(97)00026-7
10141821 100056 None 0 Rat Binding pKi = 8.5 8.5 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 501 6 1 7 4.8 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 10.1016/S0960-894X(97)00026-7
CHEMBL287116 100056 None 0 Rat Binding pKi = 8.5 8.5 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 501 6 1 7 4.8 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 10.1016/S0960-894X(97)00026-7
9804423 202722 None 0 Rat Binding pKi = 8.5 8.5 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 451 7 2 6 5.5 CCCc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81146-X
CHEMBL61814 202722 None 0 Rat Binding pKi = 8.5 8.5 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 451 7 2 6 5.5 CCCc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81146-X
19029618 117853 None 0 Rat Binding pKi = 8.5 8.5 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 545 6 1 7 4.9 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Br)s1 10.1016/S0960-894X(97)00026-7
CHEMBL340304 117853 None 0 Rat Binding pKi = 8.5 8.5 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 545 6 1 7 4.9 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Br)s1 10.1016/S0960-894X(97)00026-7
2541 785 None 120 Human Binding pKi = 8.5 8.5 -1 6
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
587 785 None 120 Human Binding pKi = 8.5 8.5 -1 6
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
6907 785 None 120 Human Binding pKi = 8.5 8.5 -1 6
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL1016 785 None 120 Human Binding pKi = 8.5 8.5 -1 6
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
DB00796 785 None 120 Human Binding pKi = 8.5 8.5 -1 6
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
DB13919 785 None 120 Human Binding pKi = 8.5 8.5 -1 6
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acs.jmedchem.5b01495
1610 2345 None 95 Rat Binding pKi = 8.4 8.4 -1 4
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00041a016
3941 2345 None 95 Rat Binding pKi = 8.4 8.4 -1 4
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00041a016
3961 2345 None 95 Rat Binding pKi = 8.4 8.4 -1 4
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00041a016
590 2345 None 95 Rat Binding pKi = 8.4 8.4 -1 4
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00041a016
CHEMBL191 2345 None 95 Rat Binding pKi = 8.4 8.4 -1 4
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00041a016
DB00678 2345 None 95 Rat Binding pKi = 8.4 8.4 -1 4
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00041a016
CHEMBL1076631 208482 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
44350472 18307 None 0 Rat Binding pKi = 8.4 8.4 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 593 6 1 7 4.7 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2I)s1 10.1016/S0960-894X(97)00026-7
CHEMBL127068 18307 None 0 Rat Binding pKi = 8.4 8.4 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 593 6 1 7 4.7 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2I)s1 10.1016/S0960-894X(97)00026-7
10096683 207087 None 0 Human Binding pKi = 8.4 8.4 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 480 6 2 8 4.4 CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 10.1021/jm00014a024
CHEMBL91928 207087 None 0 Human Binding pKi = 8.4 8.4 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 480 6 2 8 4.4 CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 10.1021/jm00014a024
3936 2208 None 35 Rat Binding pKi = 8.4 8.4 -1 4
Displacement of [125I]Ang II from AT1 receptor in rat liver membranesDisplacement of [125I]Ang II from AT1 receptor in rat liver membranes
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/acs.jmedchem.9b01780
6603900 2208 None 35 Rat Binding pKi = 8.4 8.4 -1 4
Displacement of [125I]Ang II from AT1 receptor in rat liver membranesDisplacement of [125I]Ang II from AT1 receptor in rat liver membranes
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/acs.jmedchem.9b01780
CHEMBL288174 2208 None 35 Rat Binding pKi = 8.4 8.4 -1 4
Displacement of [125I]Ang II from AT1 receptor in rat liver membranesDisplacement of [125I]Ang II from AT1 receptor in rat liver membranes
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/acs.jmedchem.9b01780
3936 2208 None 35 Rat Binding pKi = 8.4 8.4 -1 4
Displacement of [I125I]AngII form AT1 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting methodDisplacement of [I125I]AngII form AT1 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting method
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
6603900 2208 None 35 Rat Binding pKi = 8.4 8.4 -1 4
Displacement of [I125I]AngII form AT1 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting methodDisplacement of [I125I]AngII form AT1 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting method
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
CHEMBL288174 2208 None 35 Rat Binding pKi = 8.4 8.4 -1 4
Displacement of [I125I]AngII form AT1 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting methodDisplacement of [I125I]AngII form AT1 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting method
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
44284325 14772 None 0 Rat Binding pKi = 7.5 7.5 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 603 12 1 10 6.1 CCCCc1nc(Cl)c(C(=O)OC(OC(=O)CC)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL1206585 14772 None 0 Rat Binding pKi = 7.5 7.5 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 603 12 1 10 6.1 CCCCc1nc(Cl)c(C(=O)OC(OC(=O)CC)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL2079768 14772 None 0 Rat Binding pKi = 7.5 7.5 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 603 12 1 10 6.1 CCCCc1nc(Cl)c(C(=O)OC(OC(=O)CC)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
10348632 205426 None 0 Rat Binding pKi = 7.5 7.5 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 440 7 2 8 3.9 CCCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL80218 205426 None 0 Rat Binding pKi = 7.5 7.5 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 440 7 2 8 3.9 CCCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
11672486 98509 None 0 Rat Binding pKi = 7.5 7.5 -3 2
Binding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree CBinding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree C
ChEMBL 994 25 12 12 0.3 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL276163 98509 None 0 Rat Binding pKi = 7.5 7.5 -3 2
Binding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree CBinding affinity for angiotensin II receptor, type 1 in rat liver membrane using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 2 hr at 25 degree C
ChEMBL 994 25 12 12 0.3 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL5283862 194229 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 295 3 2 4 2.5 O=C(O)c1c(CO)n(C(=O)c2ccccc2)c2ccccc12 10.1016/j.bmcl.2023.129349
CHEMBL5276125 193882 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assayDisplacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
ChEMBL 385 6 1 4 4.7 O=C(O)c1c(COCc2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 10.1016/j.bmcl.2023.129349
44567781 183720 None 0 Pig Binding pKi = 7.5 7.5 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 542 11 1 6 6.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)Cc2ccccc2)cc1 10.1016/j.bmc.2008.05.066
CHEMBL480340 183720 None 0 Pig Binding pKi = 7.5 7.5 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 542 11 1 6 6.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)Cc2ccccc2)cc1 10.1016/j.bmc.2008.05.066
CHEMBL1076664 208487 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
155526996 171138 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 549 14 3 5 6.8 CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4458466 171138 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 549 14 3 5 6.8 CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
87218835 171182 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 539 13 3 5 6.3 CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4459070 171182 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 539 13 3 5 6.3 CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
155552503 174168 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 533 13 3 5 6.5 CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4547120 174168 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 533 13 3 5 6.5 CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
10764613 206905 None 0 Human Binding pKi = 5.5 5.5 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 420 7 1 3 4.5 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm9904147
CHEMBL90887 206905 None 0 Human Binding pKi = 5.5 5.5 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 420 7 1 3 4.5 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm9904147
145952582 162975 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 782 12 0 6 10.6 CCCCC1=N/C(=C\c2ccccc2Br)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1 10.1016/j.ejmech.2017.12.021
CHEMBL4175147 162975 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-Ang2 from human angiotensin 2 receptor type 1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
ChEMBL 782 12 0 6 10.6 CCCCC1=N/C(=C\c2ccccc2Br)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1 10.1016/j.ejmech.2017.12.021
19029482 117049 None 0 Rat Binding pKi = 6.5 6.5 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 545 6 1 7 4.9 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(Br)cc2)s1 10.1016/S0960-894X(97)00026-7
CHEMBL339120 117049 None 0 Rat Binding pKi = 6.5 6.5 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 545 6 1 7 4.9 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(Br)cc2)s1 10.1016/S0960-894X(97)00026-7
10507383 106103 None 0 Human Binding pKi = 7.5 7.5 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 575 12 1 5 5.6 CCCCN1C(=O)C(C)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9904147
CHEMBL313392 106103 None 0 Human Binding pKi = 7.5 7.5 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 575 12 1 5 5.6 CCCCN1C(=O)C(C)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9904147
11801362 107085 None 0 Human Binding pKi = 7.5 7.5 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 580 9 2 5 5.1 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC2CCCCC2)cc1 10.1021/jm9904147
CHEMBL315873 107085 None 0 Human Binding pKi = 7.5 7.5 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 580 9 2 5 5.1 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC2CCCCC2)cc1 10.1021/jm9904147
10025379 205287 None 0 Rat Binding pKi = 7.5 7.5 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 424 6 1 7 4.1 CCCc1nc(C)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL79171 205287 None 0 Rat Binding pKi = 7.5 7.5 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 424 6 1 7 4.1 CCCc1nc(C)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
10324104 205533 None 0 Rat Binding pKi = 7.5 7.5 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 511 10 2 10 3.8 CCCc1nc(C)n2nc(NCC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL80967 205533 None 0 Rat Binding pKi = 7.5 7.5 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 511 10 2 10 3.8 CCCc1nc(C)n2nc(NCC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
9914750 203250 None 0 Rat Binding pKi = 7.5 7.5 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 483 6 2 6 6.1 O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2cc(Cl)ccc12 10.1016/S0960-894X(01)81146-X
CHEMBL64567 203250 None 0 Rat Binding pKi = 7.5 7.5 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 483 6 2 6 6.1 O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2cc(Cl)ccc12 10.1016/S0960-894X(01)81146-X
19029652 118094 None 0 Rat Binding pKi = 6.5 6.5 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 501 6 1 7 4.8 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(Cl)cc2)s1 10.1016/S0960-894X(97)00026-7
CHEMBL340662 118094 None 0 Rat Binding pKi = 6.5 6.5 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 501 6 1 7 4.8 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(Cl)cc2)s1 10.1016/S0960-894X(97)00026-7
23298208 203162 None 0 Rat Binding pKi = 7.5 7.5 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 479 7 2 7 5.5 COc1ccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c2c1 10.1016/S0960-894X(01)81146-X
CHEMBL64220 203162 None 0 Rat Binding pKi = 7.5 7.5 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 479 7 2 7 5.5 COc1ccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c2c1 10.1016/S0960-894X(01)81146-X
10765881 206904 None 0 Human Binding pKi = 5.5 5.5 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 448 8 1 4 4.1 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)c2ccccc2C(=O)O)cc1 10.1021/jm9904147
CHEMBL90885 206904 None 0 Human Binding pKi = 5.5 5.5 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 448 8 1 4 4.1 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)c2ccccc2C(=O)O)cc1 10.1021/jm9904147
44567818 183884 None 0 Pig Binding pKi = 6.5 6.5 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 508 9 1 7 4.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCOCC2)cc1 10.1016/j.bmc.2008.05.066
CHEMBL481106 183884 None 0 Pig Binding pKi = 6.5 6.5 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 508 9 1 7 4.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCOCC2)cc1 10.1016/j.bmc.2008.05.066
10321731 163445 None 0 Rat Binding pKi = 7.5 7.5 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 454 7 2 8 3.5 CCCc1nc(C)n2nc(C(=O)O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL419835 163445 None 0 Rat Binding pKi = 7.5 7.5 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 454 7 2 8 3.5 CCCc1nc(C)n2nc(C(=O)O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
10251107 205004 None 0 Rat Binding pKi = 7.5 7.5 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 412 5 2 8 3.1 CCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL76787 205004 None 0 Rat Binding pKi = 7.5 7.5 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 412 5 2 8 3.1 CCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
44350526 18205 None 0 Rat Binding pKi = 7.5 7.5 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 481 6 1 7 4.5 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C)s1 10.1016/S0960-894X(97)00026-7
CHEMBL127002 18205 None 0 Rat Binding pKi = 7.5 7.5 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 481 6 1 7 4.5 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C)s1 10.1016/S0960-894X(97)00026-7
19029576 99971 None 0 Rat Binding pKi = 7.4 7.4 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 467 6 1 7 4.1 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2)s1 10.1016/S0960-894X(97)00026-7
CHEMBL286537 99971 None 0 Rat Binding pKi = 7.4 7.4 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 467 6 1 7 4.1 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2)s1 10.1016/S0960-894X(97)00026-7
44567744 183882 None 0 Pig Binding pKi = 7.4 7.4 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 466 9 1 6 4.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)C)cc1 10.1016/j.bmc.2008.05.066
CHEMBL481088 183882 None 0 Pig Binding pKi = 7.4 7.4 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 466 9 1 6 4.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)C)cc1 10.1016/j.bmc.2008.05.066
18950393 168175 None 0 Rat Binding pKi = 5.4 5.4 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 441 8 2 7 4.1 CCCCc1ncc(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL433230 168175 None 0 Rat Binding pKi = 5.4 5.4 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 441 8 2 7 4.1 CCCCc1ncc(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
44312565 204769 None 0 Human Binding pKi = 6.4 6.4 - 1
Inhibition constant against Angiotensin II receptor, type 1 was determinedInhibition constant against Angiotensin II receptor, type 1 was determined
ChEMBL 437 9 3 6 3.1 CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C 10.1021/jm0204237
CHEMBL74767 204769 None 0 Human Binding pKi = 6.4 6.4 - 1
Inhibition constant against Angiotensin II receptor, type 1 was determinedInhibition constant against Angiotensin II receptor, type 1 was determined
ChEMBL 437 9 3 6 3.1 CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C 10.1021/jm0204237
9872676 78193 None 0 Human Binding pKi = 5.4 5.4 -9332 17
Binding affinity to human AT1 receptorBinding affinity to human AT1 receptor
ChEMBL 565 11 2 10 4.8 COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 10.1021/jm060012g
CHEMBL210514 78193 None 0 Human Binding pKi = 5.4 5.4 -9332 17
Binding affinity to human AT1 receptorBinding affinity to human AT1 receptor
ChEMBL 565 11 2 10 4.8 COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 10.1021/jm060012g
10790818 206919 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 478 5 1 5 4.7 Cc1ccc(N2C(=O)C3(CCCC3)C(=O)N2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1021/jm9904147
CHEMBL90999 206919 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 478 5 1 5 4.7 Cc1ccc(N2C(=O)C3(CCCC3)C(=O)N2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1021/jm9904147
44283775 14777 None 0 Rat Binding pKi = 7.4 7.4 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 591 9 1 8 6.8 CCCCc1nc(Cl)c(C(=O)Oc2ccc3c(c2)CCC3)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL1206631 14777 None 0 Rat Binding pKi = 7.4 7.4 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 591 9 1 8 6.8 CCCCc1nc(Cl)c(C(=O)Oc2ccc3c(c2)CCC3)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL2079770 14777 None 0 Rat Binding pKi = 7.4 7.4 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 591 9 1 8 6.8 CCCCc1nc(Cl)c(C(=O)Oc2ccc3c(c2)CCC3)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
87218678 170333 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 521 13 3 5 6.2 CCCCc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4447138 170333 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 521 13 3 5 6.2 CCCCc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
75031588 173706 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 541 13 3 5 6.5 CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4535903 173706 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 541 13 3 5 6.5 CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
168274602 190374 None 0 Human Binding pKi = 6.4 6.4 -97 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 11 1 6 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5177359 190374 None 0 Human Binding pKi = 6.4 6.4 -97 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 11 1 6 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10695405 206518 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 463 8 2 4 4.1 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm9904147
CHEMBL88471 206518 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 463 8 2 4 4.1 CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm9904147
155522135 170653 None 0 Human Binding pKi = 6.4 6.4 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 651 14 3 5 8.4 CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4451425 170653 None 0 Human Binding pKi = 6.4 6.4 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 651 14 3 5 8.4 CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
87218371 173669 None 0 Human Binding pKi = 6.4 6.4 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 625 13 3 5 7.9 CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2cccc3ccccc23)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4534876 173669 None 0 Human Binding pKi = 6.4 6.4 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 625 13 3 5 7.9 CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2cccc3ccccc23)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
10095241 111468 None 0 Human Binding pKi = 8.4 8.4 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 449 4 1 6 4.7 Cc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 10.1021/jm00014a024
CHEMBL327633 111468 None 0 Human Binding pKi = 8.4 8.4 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 449 4 1 6 4.7 Cc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 10.1021/jm00014a024
10028164 112574 None 0 Human Binding pKi = 8.4 8.4 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 481 6 1 8 4.3 CCOC(=O)c1c(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C 10.1021/jm00014a024
CHEMBL330109 112574 None 0 Human Binding pKi = 8.4 8.4 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 481 6 1 8 4.3 CCOC(=O)c1c(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C 10.1021/jm00014a024
135723852 139138 None 0 Rat Binding pKi = 8.4 8.4 - 1
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 438 8 2 6 4.4 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmc.2016.03.028
CHEMBL3787050 139138 None 0 Rat Binding pKi = 8.4 8.4 - 1
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting methodDisplacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method
ChEMBL 438 8 2 6 4.4 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmc.2016.03.028
44284107 14609 None 0 Rat Binding pKi = 8.4 8.4 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 561 10 1 10 5.1 CCCCc1nc(Cl)c(C(=O)OC(C)OC(C)=O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL1204966 14609 None 0 Rat Binding pKi = 8.4 8.4 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 561 10 1 10 5.1 CCCCc1nc(Cl)c(C(=O)OC(C)OC(C)=O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL2079784 14609 None 0 Rat Binding pKi = 8.4 8.4 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 561 10 1 10 5.1 CCCCc1nc(Cl)c(C(=O)OC(C)OC(C)=O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
23298211 163208 None 0 Rat Binding pKi = 8.3 8.3 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 450 6 2 7 4.8 O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ncccc12 10.1016/S0960-894X(01)81146-X
CHEMBL418306 163208 None 0 Rat Binding pKi = 8.3 8.3 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 450 6 2 7 4.8 O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ncccc12 10.1016/S0960-894X(01)81146-X
11813485 18087 None 0 Rat Binding pKi = 8.3 8.3 8 2
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
ChEMBL 534 9 1 6 6.0 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm020138n
CHEMBL126755 18087 None 0 Rat Binding pKi = 8.3 8.3 8 2
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
ChEMBL 534 9 1 6 6.0 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm020138n
10697829 207136 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 545 8 1 5 4.5 CCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9904147
CHEMBL92225 207136 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 545 8 1 5 4.5 CCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9904147
168290795 191945 None 0 Human Binding pKi = 6.4 6.4 -33 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 559 11 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5200734 191945 None 0 Human Binding pKi = 6.4 6.4 -33 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 559 11 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10790819 111460 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 478 6 1 5 4.4 O=C1N(Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)C12CCCC2 10.1021/jm9904147
CHEMBL327594 111460 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 478 6 1 5 4.4 O=C1N(Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)C12CCCC2 10.1021/jm9904147
44567852 183804 None 0 Pig Binding pKi = 6.4 6.4 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 432 9 1 5 4.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
CHEMBL480507 183804 None 0 Pig Binding pKi = 6.4 6.4 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 432 9 1 5 4.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
123814 421 None 30 Human Binding pKi = 6.4 6.4 - 1
Displacement of [3H]valsartan from human AT1 receptor expressed in CHO cellsDisplacement of [3H]valsartan from human AT1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm701490g
5368 421 None 30 Human Binding pKi = 6.4 6.4 - 1
Displacement of [3H]valsartan from human AT1 receptor expressed in CHO cellsDisplacement of [3H]valsartan from human AT1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm701490g
CHEMBL261120 421 None 30 Human Binding pKi = 6.4 6.4 - 1
Displacement of [3H]valsartan from human AT1 receptor expressed in CHO cellsDisplacement of [3H]valsartan from human AT1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm701490g
123814 421 None 30 Human Binding pKi = 6.4 6.4 - 1
Displacement of [3H]valsartan from human recombinant AT1 receptor expressed in CHO cells after 40 mins by liquid scintillation countingDisplacement of [3H]valsartan from human recombinant AT1 receptor expressed in CHO cells after 40 mins by liquid scintillation counting
ChEMBL None None None None 10.1021/jm900651p
5368 421 None 30 Human Binding pKi = 6.4 6.4 - 1
Displacement of [3H]valsartan from human recombinant AT1 receptor expressed in CHO cells after 40 mins by liquid scintillation countingDisplacement of [3H]valsartan from human recombinant AT1 receptor expressed in CHO cells after 40 mins by liquid scintillation counting
ChEMBL None None None None 10.1021/jm900651p
CHEMBL261120 421 None 30 Human Binding pKi = 6.4 6.4 - 1
Displacement of [3H]valsartan from human recombinant AT1 receptor expressed in CHO cells after 40 mins by liquid scintillation countingDisplacement of [3H]valsartan from human recombinant AT1 receptor expressed in CHO cells after 40 mins by liquid scintillation counting
ChEMBL None None None None 10.1021/jm900651p
10480349 205416 None 0 Rat Binding pKi = 7.4 7.4 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 481 7 3 8 3.2 CCCc1nc(C)n2c(O)nnc2c1Cc1ccc(NC(=O)c2ccccc2S(=O)(=O)O)cc1 10.1021/jm00041a016
CHEMBL80167 205416 None 0 Rat Binding pKi = 7.4 7.4 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 481 7 3 8 3.2 CCCc1nc(C)n2c(O)nnc2c1Cc1ccc(NC(=O)c2ccccc2S(=O)(=O)O)cc1 10.1021/jm00041a016
10050326 119201 None 0 Rat Binding pKi = 7.4 7.4 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 468 9 1 5 5.9 CCCCC1=NC(Cl)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
CHEMBL343251 119201 None 0 Rat Binding pKi = 7.4 7.4 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 468 9 1 5 5.9 CCCCC1=NC(Cl)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
168279676 191127 None 0 Human Binding pKi = 6.4 6.4 -11 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5188126 191127 None 0 Human Binding pKi = 6.4 6.4 -11 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10744859 206589 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 533 9 1 5 4.4 CCCCN1C(=O)C(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9904147
CHEMBL88924 206589 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5
ChEMBL 533 9 1 5 4.4 CCCCN1C(=O)C(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9904147
44350541 118443 None 0 Rat Binding pKi = 6.4 6.4 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 535 6 1 7 5.2 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(C(F)(F)F)c2)s1 10.1016/S0960-894X(97)00026-7
CHEMBL341109 118443 None 0 Rat Binding pKi = 6.4 6.4 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 535 6 1 7 5.2 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(C(F)(F)F)c2)s1 10.1016/S0960-894X(97)00026-7
10053872 163475 None 0 Rat Binding pKi = 7.3 7.3 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 412 6 2 8 3.2 CCCc1ncn2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL420028 163475 None 0 Rat Binding pKi = 7.3 7.3 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 412 6 2 8 3.2 CCCc1ncn2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
168287840 191304 None 0 Human Binding pKi = 6.3 6.3 -32 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 12 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5191241 191304 None 0 Human Binding pKi = 6.3 6.3 -32 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 12 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
19029545 18013 None 0 Rat Binding pKi = 7.3 7.3 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 481 6 1 7 4.5 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(C)cc2)s1 10.1016/S0960-894X(97)00026-7
CHEMBL126351 18013 None 0 Rat Binding pKi = 7.3 7.3 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 481 6 1 7 4.5 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(C)cc2)s1 10.1016/S0960-894X(97)00026-7
2806 3967 None 110 Human Binding pKi = 5.3 5.3 - 1
Inhibition constant against Angiotensin II receptor, type 1 was determinedInhibition constant against Angiotensin II receptor, type 1 was determined
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm0204237
3937 3967 None 110 Human Binding pKi = 5.3 5.3 - 1
Inhibition constant against Angiotensin II receptor, type 1 was determinedInhibition constant against Angiotensin II receptor, type 1 was determined
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm0204237
593 3967 None 110 Human Binding pKi = 5.3 5.3 - 1
Inhibition constant against Angiotensin II receptor, type 1 was determinedInhibition constant against Angiotensin II receptor, type 1 was determined
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm0204237
60846 3967 None 110 Human Binding pKi = 5.3 5.3 - 1
Inhibition constant against Angiotensin II receptor, type 1 was determinedInhibition constant against Angiotensin II receptor, type 1 was determined
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm0204237
CHEMBL1069 3967 None 110 Human Binding pKi = 5.3 5.3 - 1
Inhibition constant against Angiotensin II receptor, type 1 was determinedInhibition constant against Angiotensin II receptor, type 1 was determined
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm0204237
DB00177 3967 None 110 Human Binding pKi = 5.3 5.3 - 1
Inhibition constant against Angiotensin II receptor, type 1 was determinedInhibition constant against Angiotensin II receptor, type 1 was determined
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/jm0204237
44350499 194936 None 0 Rat Binding pKi = 7.3 7.3 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 497 7 1 8 4.2 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(OC)c2)s1 10.1016/S0960-894X(97)00026-7
CHEMBL541992 194936 None 0 Rat Binding pKi = 7.3 7.3 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 497 7 1 8 4.2 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(OC)c2)s1 10.1016/S0960-894X(97)00026-7
10388491 205114 None 0 Rat Binding pKi = 8.3 8.3 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 439 7 2 8 3.9 CCCc1nc(C)n2nc(NC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL77783 205114 None 0 Rat Binding pKi = 8.3 8.3 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 439 7 2 8 3.9 CCCc1nc(C)n2nc(NC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
10388529 205506 None 0 Rat Binding pKi = 8.3 8.3 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 440 7 2 8 3.3 CCCc1nc(C)n2nc(CO)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL80773 205506 None 0 Rat Binding pKi = 8.3 8.3 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 440 7 2 8 3.3 CCCc1nc(C)n2nc(CO)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
1610 2345 None 95 Human Binding pKi = 8.3 8.3 1 4
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acsmedchemlett.8b00462
3941 2345 None 95 Human Binding pKi = 8.3 8.3 1 4
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acsmedchemlett.8b00462
3961 2345 None 95 Human Binding pKi = 8.3 8.3 1 4
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acsmedchemlett.8b00462
590 2345 None 95 Human Binding pKi = 8.3 8.3 1 4
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acsmedchemlett.8b00462
CHEMBL191 2345 None 95 Human Binding pKi = 8.3 8.3 1 4
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acsmedchemlett.8b00462
DB00678 2345 None 95 Human Binding pKi = 8.3 8.3 1 4
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/acsmedchemlett.8b00462
87218492 170903 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 535 14 3 5 6.4 CCCCc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4454778 170903 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 535 14 3 5 6.4 CCCCc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
87218698 172287 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 6 5.4 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 10.1021/acsmedchemlett.8b00462
CHEMBL4474870 172287 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 6 5.4 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 10.1021/acsmedchemlett.8b00462
25190005 174035 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 545 12 3 6 5.5 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1cc(F)c(-c2ccccc2C(=O)O)cc1F 10.1021/acsmedchemlett.8b00462
CHEMBL4543532 174035 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 545 12 3 6 5.5 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1cc(F)c(-c2ccccc2C(=O)O)cc1F 10.1021/acsmedchemlett.8b00462
9846347 198635 None 0 Rat Binding pKi = 8.2 8.2 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 437 6 2 6 5.1 CCc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81146-X
CHEMBL57907 198635 None 0 Rat Binding pKi = 8.2 8.2 - 1
Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneInhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane
ChEMBL 437 6 2 6 5.1 CCc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81146-X
44350543 96690 None 0 Rat Binding pKi = 8.2 8.2 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 535 6 1 7 5.2 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(F)(F)F)s1 10.1016/S0960-894X(97)00026-7
CHEMBL264003 96690 None 0 Rat Binding pKi = 8.2 8.2 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 535 6 1 7 5.2 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(F)(F)F)s1 10.1016/S0960-894X(97)00026-7
10340697 104744 None 0 Rat Binding pKi = 7.3 7.3 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 396 6 1 7 3.5 CCCc1ncn2ncnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL310678 104744 None 0 Rat Binding pKi = 7.3 7.3 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 396 6 1 7 3.5 CCCc1ncn2ncnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
155529942 171474 None 0 Human Binding pKi = 7.3 7.3 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 569 15 3 5 7.3 CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(CC)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4463575 171474 None 0 Human Binding pKi = 7.3 7.3 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 569 15 3 5 7.3 CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(CC)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
155547799 173686 None 0 Human Binding pKi = 7.3 7.3 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 521 13 3 5 6.2 CCCCc1nc(C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4535256 173686 None 0 Human Binding pKi = 7.3 7.3 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 521 13 3 5 6.2 CCCCc1nc(C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
87218352 174420 None 0 Human Binding pKi = 7.3 7.3 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 567 13 3 5 7.0 CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4552884 174420 None 0 Human Binding pKi = 7.3 7.3 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 567 13 3 5 7.0 CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
45488150 197018 None 0 Rat Binding pKi = 5.3 5.3 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 362 7 1 6 3.4 CCCc1nc2c(C)cccc2n1Cc1ccc(OCc2nnn[nH]2)cc1 10.1021/jm901272d
CHEMBL567054 197018 None 0 Rat Binding pKi = 5.3 5.3 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
ChEMBL 362 7 1 6 3.4 CCCc1nc2c(C)cccc2n1Cc1ccc(OCc2nnn[nH]2)cc1 10.1021/jm901272d
25141240 183591 None 0 Pig Binding pKi = 7.3 7.3 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 508 10 1 5 5.7 CCCCOC(=O)NS(=O)(=O)c1ccc(-c2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
CHEMBL480122 183591 None 0 Pig Binding pKi = 7.3 7.3 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 508 10 1 5 5.7 CCCCOC(=O)NS(=O)(=O)c1ccc(-c2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
10410991 204949 None 0 Rat Binding pKi = 7.3 7.3 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 440 6 1 8 3.1 CCCc1nc(C)n2c(=O)n(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL76421 204949 None 0 Rat Binding pKi = 7.3 7.3 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 440 6 1 8 3.1 CCCc1nc(C)n2c(=O)n(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
24828743 96166 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [3H]valsartan from human AT1 receptor expressed in CHO cellsDisplacement of [3H]valsartan from human AT1 receptor expressed in CHO cells
ChEMBL 788 20 8 9 1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm701490g
CHEMBL260622 96166 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [3H]valsartan from human AT1 receptor expressed in CHO cellsDisplacement of [3H]valsartan from human AT1 receptor expressed in CHO cells
ChEMBL 788 20 8 9 1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm701490g
19029649 17941 None 0 Rat Binding pKi = 6.3 6.3 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 535 6 1 7 5.2 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(C(F)(F)F)cc2)s1 10.1016/S0960-894X(97)00026-7
CHEMBL125964 17941 None 0 Rat Binding pKi = 6.3 6.3 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 535 6 1 7 5.2 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(C(F)(F)F)cc2)s1 10.1016/S0960-894X(97)00026-7
10457973 14681 None 0 Rat Binding pKi = 7.2 7.2 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 482 9 1 5 6.2 CCCCC1=NC(C)(C)C(C(=O)OCC)=C(Cl)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
CHEMBL1205756 14681 None 0 Rat Binding pKi = 7.2 7.2 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 482 9 1 5 6.2 CCCCC1=NC(C)(C)C(C(=O)OCC)=C(Cl)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
CHEMBL145036 14681 None 0 Rat Binding pKi = 7.2 7.2 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 482 9 1 5 6.2 CCCCC1=NC(C)(C)C(C(=O)OCC)=C(Cl)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
CHEMBL1076629 208480 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma countingDisplacement of [125I][Sar1,Ile8]Ang2 from human AT1 receptor N111G constitutively active mutant expressed in CHO cells by gamma counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm9015747
9895957 10671 None 18 Rat Binding pKi = 8.2 8.2 -3 3
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1021/jm020138n
CHEMBL11706 10671 None 18 Rat Binding pKi = 8.2 8.2 -3 3
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1021/jm020138n
9982165 205461 None 0 Rat Binding pKi = 8.2 8.2 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 470 8 2 9 2.6 CCCc1nc(C)n2c(=O)n(CCO)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL80446 205461 None 0 Rat Binding pKi = 8.2 8.2 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 470 8 2 9 2.6 CCCc1nc(C)n2c(=O)n(CCO)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
18950387 14566 None 0 Rat Binding pKi = 8.2 8.2 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 461 8 2 7 4.5 CCCCc1nc(Cl)c(CO)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL1204443 14566 None 0 Rat Binding pKi = 8.2 8.2 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 461 8 2 7 4.5 CCCCc1nc(Cl)c(CO)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL1790055 14566 None 0 Rat Binding pKi = 8.2 8.2 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 461 8 2 7 4.5 CCCCc1nc(Cl)c(CO)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
44283773 14612 None 0 Rat Binding pKi = 8.2 8.2 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 588 12 1 9 5.1 CCCCc1nc(Cl)c(C(=O)OCC(=O)N(CC)CC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL1204974 14612 None 0 Rat Binding pKi = 8.2 8.2 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 588 12 1 9 5.1 CCCCc1nc(Cl)c(C(=O)OCC(=O)N(CC)CC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL2021415 14612 None 0 Rat Binding pKi = 8.2 8.2 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 588 12 1 9 5.1 CCCCc1nc(Cl)c(C(=O)OCC(=O)N(CC)CC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
87218658 171008 None 0 Human Binding pKi = 8.2 8.2 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 547 14 3 5 6.7 CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4456544 171008 None 0 Human Binding pKi = 8.2 8.2 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 547 14 3 5 6.7 CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
87219028 171599 None 0 Human Binding pKi = 8.2 8.2 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 509 12 3 6 5.2 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4465325 171599 None 0 Human Binding pKi = 8.2 8.2 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 509 12 3 6 5.2 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
44567816 190343 None 0 Pig Binding pKi = 8.2 8.2 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 492 9 1 6 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCC2)cc1 10.1016/j.bmc.2008.05.066
CHEMBL517685 190343 None 0 Pig Binding pKi = 8.2 8.2 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 492 9 1 6 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCC2)cc1 10.1016/j.bmc.2008.05.066
44567780 192182 None 0 Pig Binding pKi = 8.2 8.2 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 520 10 2 6 5.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CCCCC2)cc1 10.1016/j.bmc.2008.05.066
CHEMBL520421 192182 None 0 Pig Binding pKi = 8.2 8.2 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 520 10 2 6 5.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CCCCC2)cc1 10.1016/j.bmc.2008.05.066
9910978 14607 None 0 Rat Binding pKi = 5.2 5.2 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 437 8 1 6 5.2 CCCCc1nc(Cl)c(C=O)n1Cc1ccc2nc(-c3ccccc3C(=O)O)oc2c1 10.1016/S0960-894X(01)81137-9
CHEMBL1204954 14607 None 0 Rat Binding pKi = 5.2 5.2 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 437 8 1 6 5.2 CCCCc1nc(Cl)c(C=O)n1Cc1ccc2nc(-c3ccccc3C(=O)O)oc2c1 10.1016/S0960-894X(01)81137-9
CHEMBL36259 14607 None 0 Rat Binding pKi = 5.2 5.2 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 437 8 1 6 5.2 CCCCc1nc(Cl)c(C=O)n1Cc1ccc2nc(-c3ccccc3C(=O)O)oc2c1 10.1016/S0960-894X(01)81137-9
168275495 190469 None 0 Human Binding pKi = 6.2 6.2 -66 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 519 10 1 6 6.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5178838 190469 None 0 Human Binding pKi = 6.2 6.2 -66 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 519 10 1 6 6.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10251334 205000 None 0 Rat Binding pKi = 6.2 6.2 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 416 7 2 6 4.4 CCCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00041a016
CHEMBL76775 205000 None 0 Rat Binding pKi = 6.2 6.2 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 416 7 2 6 4.4 CCCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00041a016
155533580 171874 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 5 6.3 CCCCc1nc(Cl)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4469350 171874 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 5 6.3 CCCCc1nc(Cl)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
87218397 171151 None 0 Human Binding pKi = 6.2 6.2 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 541 13 3 5 6.5 CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4458683 171151 None 0 Human Binding pKi = 6.2 6.2 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 541 13 3 5 6.5 CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
10077050 85274 None 0 Rat Binding pKi = 6.2 6.2 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
ChEMBL 586 8 0 8 7.1 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)OC)cc2C(=O)OC)cc1 10.1007/s00044-008-9153-9
CHEMBL2260198 85274 None 0 Rat Binding pKi = 6.2 6.2 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
ChEMBL 586 8 0 8 7.1 CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)OC)cc2C(=O)OC)cc1 10.1007/s00044-008-9153-9
10100370 103172 None 0 Rat Binding pKi = 6.2 6.2 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 454 8 2 8 4.2 CCCc1nc(CCC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL308138 103172 None 0 Rat Binding pKi = 6.2 6.2 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 454 8 2 8 4.2 CCCc1nc(CCC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
15657894 207091 None 0 Rat Binding pKi = 7.2 7.2 - 1
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 401 7 3 7 3.2 CCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1021/jm00070a012
CHEMBL1202852 207091 None 0 Rat Binding pKi = 7.2 7.2 - 1
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 401 7 3 7 3.2 CCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1021/jm00070a012
CHEMBL91953 207091 None 0 Rat Binding pKi = 7.2 7.2 - 1
Binding affinity against angiotensin II receptor from rat liverBinding affinity against angiotensin II receptor from rat liver
ChEMBL 401 7 3 7 3.2 CCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1021/jm00070a012
9805192 90953 None 0 Pig Binding pKi = 8.2 8.2 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 480 10 1 6 4.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC(=O)N(C)C)cc1 10.1016/j.bmc.2008.05.066
CHEMBL239393 90953 None 0 Pig Binding pKi = 8.2 8.2 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 480 10 1 6 4.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC(=O)N(C)C)cc1 10.1016/j.bmc.2008.05.066
19029619 18504 None 0 Rat Binding pKi = 8.1 8.1 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 485 6 1 7 4.3 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2F)s1 10.1016/S0960-894X(97)00026-7
CHEMBL127343 18504 None 0 Rat Binding pKi = 8.1 8.1 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 485 6 1 7 4.3 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2F)s1 10.1016/S0960-894X(97)00026-7
44284094 14611 None 0 Rat Binding pKi = 8.1 8.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 531 11 1 8 6.0 CCCCOC(=O)c1c(Cl)nc(CCCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL1204972 14611 None 0 Rat Binding pKi = 8.1 8.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 531 11 1 8 6.0 CCCCOC(=O)c1c(Cl)nc(CCCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL2079782 14611 None 0 Rat Binding pKi = 8.1 8.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 531 11 1 8 6.0 CCCCOC(=O)c1c(Cl)nc(CCCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
155512629 169651 None 0 Human Binding pKi = 8.1 8.1 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 563 15 3 5 7.0 CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4437331 169651 None 0 Human Binding pKi = 8.1 8.1 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 563 15 3 5 7.0 CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
168270996 190057 None 0 Human Binding pKi = 6.2 6.2 -64 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 533 11 1 6 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5172324 190057 None 0 Human Binding pKi = 6.2 6.2 -64 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 533 11 1 6 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168287782 191822 None 0 Human Binding pKi = 6.2 6.2 -22 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 545 11 1 6 6.8 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5198739 191822 None 0 Human Binding pKi = 6.2 6.2 -22 2
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 545 11 1 6 6.8 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
18950379 14576 None 0 Rat Binding pKi = 6.1 6.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 403 8 2 5 4.4 CCCCc1ncc(CO)n1Cc1ccc2c(ccn2-c2ccccc2C(=O)O)c1 10.1016/S0960-894X(01)81137-9
CHEMBL1204547 14576 None 0 Rat Binding pKi = 6.1 6.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 403 8 2 5 4.4 CCCCc1ncc(CO)n1Cc1ccc2c(ccn2-c2ccccc2C(=O)O)c1 10.1016/S0960-894X(01)81137-9
CHEMBL287065 14576 None 0 Rat Binding pKi = 6.1 6.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 403 8 2 5 4.4 CCCCc1ncc(CO)n1Cc1ccc2c(ccn2-c2ccccc2C(=O)O)c1 10.1016/S0960-894X(01)81137-9
18950381 14577 None 0 Rat Binding pKi = 7.1 7.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 403 8 2 5 4.4 CCCCc1ncc(CO)n1Cc1cccc2c1ccn2-c1ccccc1C(=O)O 10.1016/S0960-894X(01)81137-9
CHEMBL1204548 14577 None 0 Rat Binding pKi = 7.1 7.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 403 8 2 5 4.4 CCCCc1ncc(CO)n1Cc1cccc2c1ccn2-c1ccccc1C(=O)O 10.1016/S0960-894X(01)81137-9
CHEMBL288691 14577 None 0 Rat Binding pKi = 7.1 7.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 403 8 2 5 4.4 CCCCc1ncc(CO)n1Cc1cccc2c1ccn2-c1ccccc1C(=O)O 10.1016/S0960-894X(01)81137-9
9806325 14606 None 0 Rat Binding pKi = 7.1 7.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 509 8 2 7 5.1 CCCCc1nc(C(F)(F)F)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL1204952 14606 None 0 Rat Binding pKi = 7.1 7.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 509 8 2 7 5.1 CCCCc1nc(C(F)(F)F)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL4524049 14606 None 0 Rat Binding pKi = 7.1 7.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 509 8 2 7 5.1 CCCCc1nc(C(F)(F)F)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
155513439 169728 None 0 Human Binding pKi = 7.1 7.1 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 589 13 3 5 7.3 CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)c2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4438435 169728 None 0 Human Binding pKi = 7.1 7.1 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 589 13 3 5 7.3 CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)c2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
155565351 175575 None 0 Human Binding pKi = 7.1 7.1 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 575 13 3 5 6.7 CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
CHEMBL4579452 175575 None 0 Human Binding pKi = 7.1 7.1 - 1
Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 575 13 3 5 6.7 CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.8b00462
19029624 18038 None 0 Rat Binding pKi = 7.1 7.1 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 481 6 1 7 4.5 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(C)c2)s1 10.1016/S0960-894X(97)00026-7
CHEMBL126490 18038 None 0 Rat Binding pKi = 7.1 7.1 - 1
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranesInhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes
ChEMBL 481 6 1 7 4.5 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(C)c2)s1 10.1016/S0960-894X(97)00026-7
10252591 205134 None 0 Rat Binding pKi = 8.1 8.1 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 438 7 1 7 4.4 CCCc1nc(C)n2nc(CC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL78021 205134 None 0 Rat Binding pKi = 8.1 8.1 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 438 7 1 7 4.4 CCCc1nc(C)n2nc(CC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
9935424 14679 None 0 Rat Binding pKi = 8.1 8.1 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 492 9 1 7 5.3 CCCCC1=NC(Cl)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/jm00103a014
CHEMBL1205739 14679 None 0 Rat Binding pKi = 8.1 8.1 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 492 9 1 7 5.3 CCCCC1=NC(Cl)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/jm00103a014
CHEMBL141659 14679 None 0 Rat Binding pKi = 8.1 8.1 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 492 9 1 7 5.3 CCCCC1=NC(Cl)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/jm00103a014
163409135 190181 None 3 Human Binding pKi = 8.1 8.1 37 2
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 623 11 1 9 6.5 CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmc.2022.116790
CHEMBL5174180 190181 None 3 Human Binding pKi = 8.1 8.1 37 2
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 623 11 1 9 6.5 CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmc.2022.116790
10254899 206893 None 0 Human Binding pKi = 8.1 8.1 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 487 9 2 6 4.2 CCCCC(=O)N(Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1)[C@H](C(=O)O)C(C)C 10.1021/jm00014a024
CHEMBL90834 206893 None 0 Human Binding pKi = 8.1 8.1 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 487 9 2 6 4.2 CCCCC(=O)N(Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1)[C@H](C(=O)O)C(C)C 10.1021/jm00014a024
11488492 93499 None 0 Pig Binding pKi = 8.1 8.1 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 480 10 1 6 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CN(C)C(C)=O)cc1 10.1016/j.bmc.2008.05.066
CHEMBL246255 93499 None 0 Pig Binding pKi = 8.1 8.1 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 480 10 1 6 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CN(C)C(C)=O)cc1 10.1016/j.bmc.2008.05.066
44284306 14773 None 0 Rat Binding pKi = 8.1 8.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 631 11 1 10 6.8 CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL1206588 14773 None 0 Rat Binding pKi = 8.1 8.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 631 11 1 10 6.8 CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL2079781 14773 None 0 Rat Binding pKi = 8.1 8.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 631 11 1 10 6.8 CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
10884983 38306 None 0 Rat Binding pKi = 7.1 7.1 -1 2
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 458 7 1 5 4.4 CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL146275 38306 None 0 Rat Binding pKi = 7.1 7.1 -1 2
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
ChEMBL 458 7 1 5 4.4 CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
10884983 38306 None 0 Human Binding pKi = 7.1 7.1 1 2
In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5
ChEMBL 458 7 1 5 4.4 CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm010457z
CHEMBL146275 38306 None 0 Human Binding pKi = 7.1 7.1 1 2
In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5
ChEMBL 458 7 1 5 4.4 CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm010457z
10093827 204905 None 0 Rat Binding pKi = 7.1 7.1 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 424 5 2 8 3.5 Cc1nc(C2CC2)c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(O)nn12 10.1021/jm00041a016
CHEMBL76079 204905 None 0 Rat Binding pKi = 7.1 7.1 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 424 5 2 8 3.5 Cc1nc(C2CC2)c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(O)nn12 10.1021/jm00041a016
9980359 14807 None 0 Rat Binding pKi = 7.1 7.1 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 434 9 1 6 4.2 CCCCc1ncc(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
CHEMBL1207054 14807 None 0 Rat Binding pKi = 7.1 7.1 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 434 9 1 6 4.2 CCCCc1ncc(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
CHEMBL342287 14807 None 0 Rat Binding pKi = 7.1 7.1 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 434 9 1 6 4.2 CCCCc1ncc(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
18950396 14567 None 0 Rat Binding pKi = 6.1 6.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 631 8 2 7 6.3 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1c(Br)c(Br)n2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL1204444 14567 None 0 Rat Binding pKi = 6.1 6.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 631 8 2 7 6.3 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1c(Br)c(Br)n2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL4524048 14567 None 0 Rat Binding pKi = 6.1 6.1 - 1
Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesBinding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
ChEMBL 631 8 2 7 6.3 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1c(Br)c(Br)n2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
10459016 36815 None 0 Rat Binding pKi = 6.1 6.1 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 510 10 1 5 6.8 CCCCC1=NC(c2ccccc2)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
CHEMBL145017 36815 None 0 Rat Binding pKi = 6.1 6.1 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 510 10 1 5 6.8 CCCCC1=NC(c2ccccc2)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
10368569 205452 None 0 Rat Binding pKi = 8.1 8.1 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 496 9 1 9 3.9 CCCc1nc(C)n2nc(CC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL80380 205452 None 0 Rat Binding pKi = 8.1 8.1 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 496 9 1 9 3.9 CCCc1nc(C)n2nc(CC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
127034038 139195 None 0 Human Binding pKi = 8.1 8.1 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1656 46 15 20 2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3785563 139195 None 0 Human Binding pKi = 8.1 8.1 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1656 46 15 20 2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787702 139195 None 0 Human Binding pKi = 8.1 8.1 - 1
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1656 46 15 20 2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
10480064 111770 None 0 Human Binding pKi = 8.0 8.0 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 475 9 2 6 4.5 CCCCC(=O)N(Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1)[C@H](C(=O)O)C(C)C 10.1021/jm00014a024
CHEMBL328738 111770 None 0 Human Binding pKi = 8.0 8.0 - 1
Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1Ability to displace [125I]AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1
ChEMBL 475 9 2 6 4.5 CCCCC(=O)N(Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1)[C@H](C(=O)O)C(C)C 10.1021/jm00014a024
10027183 164250 None 0 Rat Binding pKi = 5.1 5.1 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 458 7 2 9 3.9 CCCc1nc(SC)n2c(O)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL421141 164250 None 0 Rat Binding pKi = 5.1 5.1 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 458 7 2 9 3.9 CCCc1nc(SC)n2c(O)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
168270075 190051 None 0 Human Binding pKi = 7.0 7.0 - 1
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 541 8 1 9 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2nc(CC(C)C)sc2S(=O)(=O)NC(=O)OC)cc1 10.1016/j.bmc.2022.116790
CHEMBL5172242 190051 None 0 Human Binding pKi = 7.0 7.0 - 1
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 541 8 1 9 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2nc(CC(C)C)sc2S(=O)(=O)NC(=O)OC)cc1 10.1016/j.bmc.2022.116790
44567884 183007 None 0 Pig Binding pKi = 7.0 7.0 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 524 11 1 6 5.8 CCCCOC(=O)NS(=O)(=O)c1ccc(Oc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
CHEMBL479367 183007 None 0 Pig Binding pKi = 7.0 7.0 - 1
Displacement of [125]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 524 11 1 6 5.8 CCCCOC(=O)NS(=O)(=O)c1ccc(Oc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 10.1016/j.bmc.2008.05.066
10348903 105409 None 0 Rat Binding pKi = 7.0 7.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 456 8 2 9 3.4 CCCc1nc(COC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL311825 105409 None 0 Rat Binding pKi = 7.0 7.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 456 8 2 9 3.4 CCCc1nc(COC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
145946191 167530 None 0 Human Binding pKi = 4.0 4.0 -1096 2
Displacement of [125I]-angiotensin 2 from human angiotensin 2 type-1 receptor expressed in CHO cell membranes after 1 hr by gamma counting analysisDisplacement of [125I]-angiotensin 2 from human angiotensin 2 type-1 receptor expressed in CHO cell membranes after 1 hr by gamma counting analysis
ChEMBL 1165 26 5 14 4.5 CCN(CC)c1ccc(C(=C2C=CC(=[N+](CC)CC)C=C2)c2ccc(S(=O)(=O)NCCCC[C@H](NC(=O)Cc3csc(=N)n3C)C(=O)N[C@@H](Cc3cn(Cc4ccccc4)c[n+]3C)C(=O)NC3CCN(C)CC3)cc2S(=O)(=O)[O-])cc1 10.1021/jm401789v
CHEMBL3234454 167530 None 0 Human Binding pKi = 4.0 4.0 -1096 2
Displacement of [125I]-angiotensin 2 from human angiotensin 2 type-1 receptor expressed in CHO cell membranes after 1 hr by gamma counting analysisDisplacement of [125I]-angiotensin 2 from human angiotensin 2 type-1 receptor expressed in CHO cell membranes after 1 hr by gamma counting analysis
ChEMBL 1165 26 5 14 4.5 CCN(CC)c1ccc(C(=C2C=CC(=[N+](CC)CC)C=C2)c2ccc(S(=O)(=O)NCCCC[C@H](NC(=O)Cc3csc(=N)n3C)C(=O)N[C@@H](Cc3cn(Cc4ccccc4)c[n+]3C)C(=O)NC3CCN(C)CC3)cc2S(=O)(=O)[O-])cc1 10.1021/jm401789v
CHEMBL4300168 167530 None 0 Human Binding pKi = 4.0 4.0 -1096 2
Displacement of [125I]-angiotensin 2 from human angiotensin 2 type-1 receptor expressed in CHO cell membranes after 1 hr by gamma counting analysisDisplacement of [125I]-angiotensin 2 from human angiotensin 2 type-1 receptor expressed in CHO cell membranes after 1 hr by gamma counting analysis
ChEMBL 1165 26 5 14 4.5 CCN(CC)c1ccc(C(=C2C=CC(=[N+](CC)CC)C=C2)c2ccc(S(=O)(=O)NCCCC[C@H](NC(=O)Cc3csc(=N)n3C)C(=O)N[C@@H](Cc3cn(Cc4ccccc4)c[n+]3C)C(=O)NC3CCN(C)CC3)cc2S(=O)(=O)[O-])cc1 10.1021/jm401789v
10369660 205414 None 0 Rat Binding pKi = 7 7.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 528 10 1 10 4.5 CCCc1nc(C)n2nc(SCC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL80161 205414 None 0 Rat Binding pKi = 7 7.0 - 1
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
ChEMBL 528 10 1 10 4.5 CCCc1nc(C)n2nc(SCC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
10456328 34766 None 0 Rat Binding pKi = 6 6.0 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 448 9 1 5 5.7 CCCCC1=NC(C)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
CHEMBL143083 34766 None 0 Rat Binding pKi = 6 6.0 - 1
Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptorInhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal cortical membrane angiotensin II receptor
ChEMBL 448 9 1 5 5.7 CCCCC1=NC(C)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00103a014
4823 93560 None 91 Bovine Binding pIC50 = 8.3 8.3 - 0
Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortexConcentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortex
Drug Central 334 3 2 4 3.1 COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 None
CHEMBL24646 93560 None 91 Bovine Binding pIC50 = 8.3 8.3 - 0
Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortexConcentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortex
Drug Central 334 3 2 4 3.1 COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 None
1610 2345 None 95 Bovine Binding pIC50 = 8.2 8.2 - 4
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 2345 None 95 Bovine Binding pIC50 = 8.2 8.2 - 4
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 2345 None 95 Bovine Binding pIC50 = 8.2 8.2 - 4
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 2345 None 95 Bovine Binding pIC50 = 8.2 8.2 - 4
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 2345 None 95 Bovine Binding pIC50 = 8.2 8.2 - 4
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 2345 None 95 Bovine Binding pIC50 = 8.2 8.2 - 4
Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortexDisplacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
1610 2345 None 95 Guinea pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 2345 None 95 Guinea pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 2345 None 95 Guinea pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 2345 None 95 Guinea pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 2345 None 95 Guinea pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 2345 None 95 Guinea pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparationIn vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
2806 3967 None 110 Rat Binding pIC50 = 8.1 8.1 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
3937 3967 None 110 Rat Binding pIC50 = 8.1 8.1 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
593 3967 None 110 Rat Binding pIC50 = 8.1 8.1 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
60846 3967 None 110 Rat Binding pIC50 = 8.1 8.1 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
CHEMBL1069 3967 None 110 Rat Binding pIC50 = 8.1 8.1 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
DB00177 3967 None 110 Rat Binding pIC50 = 8.1 8.1 - 1
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
2583 3774 None 118 Rat Binding pIC50 = 8.1 8.1 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
592 3774 None 118 Rat Binding pIC50 = 8.1 8.1 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
65999 3774 None 118 Rat Binding pIC50 = 8.1 8.1 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
CHEMBL1017 3774 None 118 Rat Binding pIC50 = 8.1 8.1 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
DB00966 3774 None 118 Rat Binding pIC50 = 8.1 8.1 - 1
Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationInhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
36736 3472 None 0 Rat Binding pIC50 = 8.1 8.1 5 3
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
Drug Central None None None None None
598 3472 None 0 Rat Binding pIC50 = 8.1 8.1 5 3
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
Drug Central None None None None None
6324663 3472 None 0 Rat Binding pIC50 = 8.1 8.1 5 3
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
Drug Central None None None None None
CHEMBL356431 3472 None 0 Rat Binding pIC50 = 8.1 8.1 5 3
Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membraneBinding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane
Drug Central None None None None None
1037 1576 None 69 Human Binding pIC50 = 8.1 8.1 - 1
Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
3940 1576 None 69 Human Binding pIC50 = 8.1 8.1 - 1
Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
5281037 1576 None 69 Human Binding pIC50 = 8.1 8.1 - 1
Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
588 1576 None 69 Human Binding pIC50 = 8.1 8.1 - 1
Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
CHEMBL813 1576 None 69 Human Binding pIC50 = 8.1 8.1 - 1
Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
DB00876 1576 None 69 Human Binding pIC50 = 8.1 8.1 - 1
Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
2806 3967 None 110 Rat Binding pIC50 = 8.1 8.1 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
3937 3967 None 110 Rat Binding pIC50 = 8.1 8.1 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
593 3967 None 110 Rat Binding pIC50 = 8.1 8.1 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
60846 3967 None 110 Rat Binding pIC50 = 8.1 8.1 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
CHEMBL1069 3967 None 110 Rat Binding pIC50 = 8.1 8.1 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
DB00177 3967 None 110 Rat Binding pIC50 = 8.1 8.1 - 1
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
1037 1576 None 69 Rat Binding pIC50 = 8.1 8.1 - 1
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
3940 1576 None 69 Rat Binding pIC50 = 8.1 8.1 - 1
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
5281037 1576 None 69 Rat Binding pIC50 = 8.1 8.1 - 1
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
588 1576 None 69 Rat Binding pIC50 = 8.1 8.1 - 1
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
CHEMBL813 1576 None 69 Rat Binding pIC50 = 8.1 8.1 - 1
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
DB00876 1576 None 69 Rat Binding pIC50 = 8.1 8.1 - 1
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
2540 4399 None 111 Human Binding pIC50 = 8.0 8.0 - 4
Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation counting
Drug Central 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 None
CHEMBL1014 4399 None 111 Human Binding pIC50 = 8.0 8.0 - 4
Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation counting
Drug Central 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 None
2583 3774 None 118 Human Binding pIC50 = 8.0 8.0 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
592 3774 None 118 Human Binding pIC50 = 8.0 8.0 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
65999 3774 None 118 Human Binding pIC50 = 8.0 8.0 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
CHEMBL1017 3774 None 118 Human Binding pIC50 = 8.0 8.0 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
DB00966 3774 None 118 Human Binding pIC50 = 8.0 8.0 - 1
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
16133225 419 None 52 Rat Binding pIC50 = 8.0 8.0 - 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
Drug Central None None None None None
172198 419 None 52 Rat Binding pIC50 = 8.0 8.0 - 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
Drug Central None None None None None
2504 419 None 52 Rat Binding pIC50 = 8.0 8.0 - 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
Drug Central None None None None None
45266664 419 None 52 Rat Binding pIC50 = 8.0 8.0 - 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
Drug Central None None None None None
5272 419 None 52 Rat Binding pIC50 = 8.0 8.0 - 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
Drug Central None None None None None
CHEMBL408403 419 None 52 Rat Binding pIC50 = 8.0 8.0 - 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
Drug Central None None None None None
DB11842 419 None 52 Rat Binding pIC50 = 8.0 8.0 - 4
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
Drug Central None None None None None
16133225 419 None 52 Bovine Binding pKd = 8.1 8.1 -14 4
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
Drug Central None None None None None
172198 419 None 52 Bovine Binding pKd = 8.1 8.1 -14 4
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
Drug Central None None None None None
2504 419 None 52 Bovine Binding pKd = 8.1 8.1 -14 4
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
Drug Central None None None None None
45266664 419 None 52 Bovine Binding pKd = 8.1 8.1 -14 4
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
Drug Central None None None None None
5272 419 None 52 Bovine Binding pKd = 8.1 8.1 -14 4
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
Drug Central None None None None None
CHEMBL408403 419 None 52 Bovine Binding pKd = 8.1 8.1 -14 4
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
Drug Central None None None None None
DB11842 419 None 52 Bovine Binding pKd = 8.1 8.1 -14 4
Dissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranesDissociation constant for [125 I] Ang binding to type 1 Angiotensin II receptor of bovine adrenocortical membranes
Drug Central None None None None None
1610 2345 None 95 Rabbit Binding pKd = 8.1 8.1 -1 4
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 2345 None 95 Rabbit Binding pKd = 8.1 8.1 -1 4
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 2345 None 95 Rabbit Binding pKd = 8.1 8.1 -1 4
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 2345 None 95 Rabbit Binding pKd = 8.1 8.1 -1 4
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 2345 None 95 Rabbit Binding pKd = 8.1 8.1 -1 4
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 2345 None 95 Rabbit Binding pKd = 8.1 8.1 -1 4
In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsIn vitro binding affinity against Angiotensin II receptor in rabbit aorta rings
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
2541 785 None 120 Human Binding pKd = 10.3 10.3 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10079018
587 785 None 120 Human Binding pKd = 10.3 10.3 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10079018
6907 785 None 120 Human Binding pKd = 10.3 10.3 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10079018
CHEMBL1016 785 None 120 Human Binding pKd = 10.3 10.3 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10079018
DB00796 785 None 120 Human Binding pKd = 10.3 10.3 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10079018
DB13919 785 None 120 Human Binding pKd = 10.3 10.3 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10079018
6916 3481 None 0 Human Binding pKd = 6.5 6.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11901215
6914 3482 None 0 Human Binding pKd = 6.5 6.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12949261
6903 3478 None 0 Rat Binding pKd = 7.1 7.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10066768
6903 3478 None 0 Rat Binding pKd = 7.1 7.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11901215
3082475 3875 None 16 Human Binding pKd = 7.7 7.7 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20801892
6902 3875 None 16 Human Binding pKd = 7.7 7.7 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20801892
CHEMBL4297447 3875 None 16 Human Binding pKd = 7.7 7.7 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20801892
DB12199 3875 None 16 Human Binding pKd = 7.7 7.7 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20801892
1610 2345 None 95 Rat Binding pKd = 8.2 8.2 -1 4
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8282008
3941 2345 None 95 Rat Binding pKd = 8.2 8.2 -1 4
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8282008
3961 2345 None 95 Rat Binding pKd = 8.2 8.2 -1 4
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8282008
590 2345 None 95 Rat Binding pKd = 8.2 8.2 -1 4
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8282008
CHEMBL191 2345 None 95 Rat Binding pKd = 8.2 8.2 -1 4
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8282008
DB00678 2345 None 95 Rat Binding pKd = 8.2 8.2 -1 4
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8282008
1481 2064 None 116 Human Binding pKd = 8.7 8.7 1 3
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 11967808
3749 2064 None 116 Human Binding pKd = 8.7 8.7 1 3
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 11967808
589 2064 None 116 Human Binding pKd = 8.7 8.7 1 3
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 11967808
6908 2064 None 116 Human Binding pKd = 8.7 8.7 1 3
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 11967808
CHEMBL1513 2064 None 116 Human Binding pKd = 8.7 8.7 1 3
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 11967808
DB01029 2064 None 116 Human Binding pKd = 8.7 8.7 1 3
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 11967808
6915 3477 None 0 Human Binding pKd = 9.1 9.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11901215
1037 1576 None 69 Rat Binding pKd = 9.1 9.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 8463997
3940 1576 None 69 Rat Binding pKd = 9.1 9.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 8463997
5281037 1576 None 69 Rat Binding pKd = 9.1 9.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 8463997
588 1576 None 69 Rat Binding pKd = 9.1 9.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 8463997
CHEMBL813 1576 None 69 Rat Binding pKd = 9.1 9.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 8463997
DB00876 1576 None 69 Rat Binding pKd = 9.1 9.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 8463997
6904 3479 None 0 Rat Binding pKd = 9.3 9.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10066768
6904 3479 None 0 Rat Binding pKd = 9.3 9.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11901215
6905 3483 None 0 Human Binding pKd = 9.4 9.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11901215
None 216162 125I-Angiotensin II 0 Rat Binding pKi = 9.2 9.2 - 1
NoneNone
PDSP KiDatabase 395 4 1 6 4.4 CCC1=NC2=C(N1C3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)N=C(C=C2C)C None
16133225 419 125I-Angiotensin II 52 Rat Binding pKi = 9.0 9.0 -2 4
NoneNone
PDSP KiDatabase None None None None None
172198 419 125I-Angiotensin II 52 Rat Binding pKi = 9.0 9.0 -2 4
NoneNone
PDSP KiDatabase None None None None None
2504 419 125I-Angiotensin II 52 Rat Binding pKi = 9.0 9.0 -2 4
NoneNone
PDSP KiDatabase None None None None None
45266664 419 125I-Angiotensin II 52 Rat Binding pKi = 9.0 9.0 -2 4
NoneNone
PDSP KiDatabase None None None None None
5272 419 125I-Angiotensin II 52 Rat Binding pKi = 9.0 9.0 -2 4
NoneNone
PDSP KiDatabase None None None None None
CHEMBL408403 419 125I-Angiotensin II 52 Rat Binding pKi = 9.0 9.0 -2 4
NoneNone
PDSP KiDatabase None None None None None
DB11842 419 125I-Angiotensin II 52 Rat Binding pKi = 9.0 9.0 -2 4
NoneNone
PDSP KiDatabase None None None None None
36736 3472 125I-Angiotensin II 0 Rat Binding pKi = 8.8 8.8 5 3
NoneNone
PDSP KiDatabase None None None None None
598 3472 125I-Angiotensin II 0 Rat Binding pKi = 8.8 8.8 5 3
NoneNone
PDSP KiDatabase None None None None None
6324663 3472 125I-Angiotensin II 0 Rat Binding pKi = 8.8 8.8 5 3
NoneNone
PDSP KiDatabase None None None None None
CHEMBL356431 3472 125I-Angiotensin II 0 Rat Binding pKi = 8.8 8.8 5 3
NoneNone
PDSP KiDatabase None None None None None
179 400 3H-angiotensin II 115 Human Binding pKi = 5 5.0 -4365 51
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
2159 400 3H-angiotensin II 115 Human Binding pKi = 5 5.0 -4365 51
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
963 400 3H-angiotensin II 115 Human Binding pKi = 5 5.0 -4365 51
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
CHEMBL243712 400 3H-angiotensin II 115 Human Binding pKi = 5 5.0 -4365 51
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
DB06288 400 3H-angiotensin II 115 Human Binding pKi = 5 5.0 -4365 51
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
135398737 957 3H-angiotensin II 93 Human Binding pKi = 5 5.0 -4168 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 957 3H-angiotensin II 93 Human Binding pKi = 5 5.0 -4168 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 957 3H-angiotensin II 93 Human Binding pKi = 5 5.0 -4168 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 957 3H-angiotensin II 93 Human Binding pKi = 5 5.0 -4168 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 957 3H-angiotensin II 93 Human Binding pKi = 5 5.0 -4168 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
1353 1909 3H-angiotensin II 93 Human Binding pKi = 5 5.0 -6918 86
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 1909 3H-angiotensin II 93 Human Binding pKi = 5 5.0 -6918 86
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 1909 3H-angiotensin II 93 Human Binding pKi = 5 5.0 -6918 86
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 1909 3H-angiotensin II 93 Human Binding pKi = 5 5.0 -6918 86
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 1909 3H-angiotensin II 93 Human Binding pKi = 5 5.0 -6918 86
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
1973 203481 125I-[SAR1, ILe8]-AII 15 Rat Binding pKi = 5 5.0 -3 37
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 203481 125I-[SAR1, ILe8]-AII 15 Rat Binding pKi = 5 5.0 -3 37
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 203481 125I-[SAR1, ILe8]-AII 15 Rat Binding pKi = 5 5.0 -3 37
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
1610 2345 125I-Angiotensin II 95 Rat Binding pKi = 7.9 7.9 -1 4
NoneNone
PDSP KiDatabase 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 2345 125I-Angiotensin II 95 Rat Binding pKi = 7.9 7.9 -1 4
NoneNone
PDSP KiDatabase 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 2345 125I-Angiotensin II 95 Rat Binding pKi = 7.9 7.9 -1 4
NoneNone
PDSP KiDatabase 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 2345 125I-Angiotensin II 95 Rat Binding pKi = 7.9 7.9 -1 4
NoneNone
PDSP KiDatabase 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 2345 125I-Angiotensin II 95 Rat Binding pKi = 7.9 7.9 -1 4
NoneNone
PDSP KiDatabase 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 2345 125I-Angiotensin II 95 Rat Binding pKi = 7.9 7.9 -1 4
NoneNone
PDSP KiDatabase 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
None 216161 125I-Angiotensin II 0 Rat Binding pKi = 8.5 8.5 - 1
NoneNone
PDSP KiDatabase 424 10 2 5 4.7 CCCCC1=NC=C(N1CC2=CC=C(C=C2)C(=O)O)C=C(CC3=CC=CS3)C(=O)O None
2806 3967 None 110 Human Binding pKi = 8.3 8.3 - 1
Inhibition constant against Angiotensin II receptor, type 1 was determinedInhibition constant against Angiotensin II receptor, type 1 was determined
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
3937 3967 None 110 Human Binding pKi = 8.3 8.3 - 1
Inhibition constant against Angiotensin II receptor, type 1 was determinedInhibition constant against Angiotensin II receptor, type 1 was determined
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
593 3967 None 110 Human Binding pKi = 8.3 8.3 - 1
Inhibition constant against Angiotensin II receptor, type 1 was determinedInhibition constant against Angiotensin II receptor, type 1 was determined
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
60846 3967 None 110 Human Binding pKi = 8.3 8.3 - 1
Inhibition constant against Angiotensin II receptor, type 1 was determinedInhibition constant against Angiotensin II receptor, type 1 was determined
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
CHEMBL1069 3967 None 110 Human Binding pKi = 8.3 8.3 - 1
Inhibition constant against Angiotensin II receptor, type 1 was determinedInhibition constant against Angiotensin II receptor, type 1 was determined
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
DB00177 3967 None 110 Human Binding pKi = 8.3 8.3 - 1
Inhibition constant against Angiotensin II receptor, type 1 was determinedInhibition constant against Angiotensin II receptor, type 1 was determined
Drug Central 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 None
1610 2345 None 95 Rat Binding pKi = 8.1 8.1 -1 4
Binding affinity against angiotensin II receptor from rat liver; n=8Binding affinity against angiotensin II receptor from rat liver; n=8
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 2345 None 95 Rat Binding pKi = 8.1 8.1 -1 4
Binding affinity against angiotensin II receptor from rat liver; n=8Binding affinity against angiotensin II receptor from rat liver; n=8
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 2345 None 95 Rat Binding pKi = 8.1 8.1 -1 4
Binding affinity against angiotensin II receptor from rat liver; n=8Binding affinity against angiotensin II receptor from rat liver; n=8
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 2345 None 95 Rat Binding pKi = 8.1 8.1 -1 4
Binding affinity against angiotensin II receptor from rat liver; n=8Binding affinity against angiotensin II receptor from rat liver; n=8
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 2345 None 95 Rat Binding pKi = 8.1 8.1 -1 4
Binding affinity against angiotensin II receptor from rat liver; n=8Binding affinity against angiotensin II receptor from rat liver; n=8
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 2345 None 95 Rat Binding pKi = 8.1 8.1 -1 4
Binding affinity against angiotensin II receptor from rat liver; n=8Binding affinity against angiotensin II receptor from rat liver; n=8
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
1610 2345 None 95 Rat Binding pKi = 8.1 8.1 -1 4
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 2345 None 95 Rat Binding pKi = 8.1 8.1 -1 4
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 2345 None 95 Rat Binding pKi = 8.1 8.1 -1 4
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 2345 None 95 Rat Binding pKi = 8.1 8.1 -1 4
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 2345 None 95 Rat Binding pKi = 8.1 8.1 -1 4
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 2345 None 95 Rat Binding pKi = 8.1 8.1 -1 4
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorDisplacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
1481 2064 None 116 Rat Binding pKi = 8.0 8.0 -1 3
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
3749 2064 None 116 Rat Binding pKi = 8.0 8.0 -1 3
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
589 2064 None 116 Rat Binding pKi = 8.0 8.0 -1 3
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
6908 2064 None 116 Rat Binding pKi = 8.0 8.0 -1 3
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
CHEMBL1513 2064 None 116 Rat Binding pKi = 8.0 8.0 -1 3
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
DB01029 2064 None 116 Rat Binding pKi = 8.0 8.0 -1 3
Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
1481 2064 None 116 Human Binding pKi = 8.0 8.0 1 3
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
3749 2064 None 116 Human Binding pKi = 8.0 8.0 1 3
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
589 2064 None 116 Human Binding pKi = 8.0 8.0 1 3
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
6908 2064 None 116 Human Binding pKi = 8.0 8.0 1 3
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
CHEMBL1513 2064 None 116 Human Binding pKi = 8.0 8.0 1 3
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
DB01029 2064 None 116 Human Binding pKi = 8.0 8.0 1 3
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
2540 4399 None 111 Rabbit Binding pKi = 8.0 8.0 -1 4
NoneNone
Drug Central 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 None
CHEMBL1014 4399 None 111 Rabbit Binding pKi = 8.0 8.0 -1 4
NoneNone
Drug Central 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 None
16133225 419 None 52 Rat Binding pKi = 8.0 8.0 -2 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
Drug Central None None None None None
172198 419 None 52 Rat Binding pKi = 8.0 8.0 -2 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
Drug Central None None None None None
2504 419 None 52 Rat Binding pKi = 8.0 8.0 -2 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
Drug Central None None None None None
45266664 419 None 52 Rat Binding pKi = 8.0 8.0 -2 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
Drug Central None None None None None
5272 419 None 52 Rat Binding pKi = 8.0 8.0 -2 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
Drug Central None None None None None
CHEMBL408403 419 None 52 Rat Binding pKi = 8.0 8.0 -2 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
Drug Central None None None None None
DB11842 419 None 52 Rat Binding pKi = 8.0 8.0 -2 4
In vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang IIIn vitro binding affinity at rat liver Angiotensin II receptor, type 1 was determined based on displacement of [125I]-Ang II
Drug Central None None None None None
1056 3369 None 116 Rat Binding pKi = 8.0 8.0 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
Drug Central 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C None
2405 3369 None 116 Rat Binding pKi = 8.0 8.0 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
Drug Central 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C None
77999 3369 None 116 Rat Binding pKi = 8.0 8.0 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
Drug Central 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C None
CHEMBL121 3369 None 116 Rat Binding pKi = 8.0 8.0 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
Drug Central 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C None
DB00412 3369 None 116 Rat Binding pKi = 8.0 8.0 - 1
Displacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hrDisplacement of [125I]-SI-Ang-2 from AT1 receptor in Rattus norvegicus Sprague-Dawley (rat) liver membranes after 2 hr
Drug Central 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C None
2583 3774 None 118 Rat Binding pKi = 8.0 8.0 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
592 3774 None 118 Rat Binding pKi = 8.0 8.0 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
65999 3774 None 118 Rat Binding pKi = 8.0 8.0 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
CHEMBL1017 3774 None 118 Rat Binding pKi = 8.0 8.0 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
DB00966 3774 None 118 Rat Binding pKi = 8.0 8.0 - 1
Displacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membraneDisplacement of [125I]SI-Ang2 from AT1 receptor in Sprague-Dawley rat liver membrane
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
36736 3472 None 0 Human Binding pKi = 8.0 8.0 -5 3
Binding affinity to human AT1 receptor by radioligand displacement assayBinding affinity to human AT1 receptor by radioligand displacement assay
Drug Central None None None None None
598 3472 None 0 Human Binding pKi = 8.0 8.0 -5 3
Binding affinity to human AT1 receptor by radioligand displacement assayBinding affinity to human AT1 receptor by radioligand displacement assay
Drug Central None None None None None
6324663 3472 None 0 Human Binding pKi = 8.0 8.0 -5 3
Binding affinity to human AT1 receptor by radioligand displacement assayBinding affinity to human AT1 receptor by radioligand displacement assay
Drug Central None None None None None
CHEMBL356431 3472 None 0 Human Binding pKi = 8.0 8.0 -5 3
Binding affinity to human AT1 receptor by radioligand displacement assayBinding affinity to human AT1 receptor by radioligand displacement assay
Drug Central None None None None None
11944 3874 None 0 Human Binding pKi = 8.3 8.3 - 1
Receptor bindingReceptor binding
Guide to Pharmacology None None None None 30639099
155552190 3874 None 0 Human Binding pKi = 8.3 8.3 - 1
Receptor bindingReceptor binding
Guide to Pharmacology None None None None 30639099
CHEMBL4544228 3874 None 0 Human Binding pKi = 8.3 8.3 - 1
Receptor bindingReceptor binding
Guide to Pharmacology None None None None 30639099
11943 3873 None 0 Human Binding pKi = 8.6 8.6 - 1
Receptor bindingReceptor binding
Guide to Pharmacology None None None None 30639099
145925549 3873 None 0 Human Binding pKi = 8.6 8.6 - 1
Receptor bindingReceptor binding
Guide to Pharmacology None None None None 30639099
CHEMBL4438122 3873 None 0 Human Binding pKi = 8.6 8.6 - 1
Receptor bindingReceptor binding
Guide to Pharmacology None None None None 30639099
11930 1018 None 0 Human Binding pKi = 6.7 6.7 -537 2
UnclassifiedUnclassified
Guide to Pharmacology 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
15780052 1018 None 0 Human Binding pKi = 6.7 6.7 -537 2
UnclassifiedUnclassified
Guide to Pharmacology 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
CHEMBL289472 1018 None 0 Human Binding pKi = 6.7 6.7 -537 2
UnclassifiedUnclassified
Guide to Pharmacology 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
11931 1064 None 0 Human Binding pKi = 8.4 8.4 -10 2
UnclassifiedUnclassified
Guide to Pharmacology 621 10 1 8 6.7 CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
126456406 1064 None 0 Human Binding pKi = 8.4 8.4 -10 2
UnclassifiedUnclassified
Guide to Pharmacology 621 10 1 8 6.7 CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
6894 418 None 0 Human Binding pKi = 8.8 8.8 1 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21464395
91691124 418 None 0 Human Binding pKi = 8.8 8.8 1 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21464395
136218976 150 None 0 Rat Binding pKi = 9.0 9.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 423 9 2 5 3.7 CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O 22410249
6913 150 None 0 Rat Binding pKi = 9.0 9.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 423 9 2 5 3.7 CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O 22410249
60921 3467 None 0 Rat Binding pKi = 9.1 9.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 610 8 2 6 5.9 CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 7853190
6899 3467 None 0 Rat Binding pKi = 9.1 9.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 610 8 2 6 5.9 CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 7853190
CHEMBL305544 3467 None 0 Rat Binding pKi = 9.1 9.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 610 8 2 6 5.9 CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 7853190
DB01347 3467 None 0 Rat Binding pKi = 9.1 9.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 610 8 2 6 5.9 CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 7853190
10257882 3644 None 43 Human Binding pKi = 9.1 9.1 11 2
UnclassifiedUnclassified
Guide to Pharmacology 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 16220969
8448 3644 None 43 Human Binding pKi = 9.1 9.1 11 2
UnclassifiedUnclassified
Guide to Pharmacology 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 16220969
CHEMBL539423 3644 None 43 Human Binding pKi = 9.1 9.1 11 2
UnclassifiedUnclassified
Guide to Pharmacology 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 16220969
DB12548 3644 None 43 Human Binding pKi = 9.1 9.1 11 2
UnclassifiedUnclassified
Guide to Pharmacology 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 16220969