GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	145971909	171479	0	None	11	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	411	11	2	6	4.8	CCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4217198	171479	0	None	11	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	411	11	2	6	4.8	CCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	66978356	170487	0	None	10	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4204996	170487	0	None	10	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	127027876	146254	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	4.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3794302	146254	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	4.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	145978309	170531	0	None	27	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	429	12	2	6	4.8	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCCCF	10.1016/j.bmc.2017.11.035
	CHEMBL4205480	170531	0	None	27	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	429	12	2	6	4.8	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCCCF	10.1016/j.bmc.2017.11.035
	127029692	146182	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793515	146182	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	11855868	159323	0	None	24	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	159323	0	None	24	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855865	160056	0	None	35	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	160056	0	None	35	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	127026955	146228	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794016	146228	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
	1883	9856	75	None	-2	12	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	1916	9856	75	None	-2	12	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	5280360	9856	75	None	-2	12	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	913	9856	75	None	-2	12	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	CHEMBL548	9856	75	None	-2	12	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	DB00917	9856	75	None	-2	12	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	18376258	202681	0	None	-	1	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559065	202681	0	None	-	1	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	127026956	146204	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793862	146204	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	126495400	146099	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3792632	146099	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	1929	8386	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	9890801	8386	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	CHEMBL563646	8386	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	DB12022	8386	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	67082748	171142	0	None	9	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	451	10	2	6	5.0	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCC(F)(F)F	10.1016/j.bmc.2017.11.035
	CHEMBL4212770	171142	0	None	9	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	451	10	2	6	5.0	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCC(F)(F)F	10.1016/j.bmc.2017.11.035
	15979081	170619	0	None	5	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCCC(C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4206444	170619	0	None	5	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCCC(C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	127051063	147100	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806284	147100	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
	127027877	146197	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.4	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793802	146197	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.4	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	16725337	156380	0	None	4	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	156380	0	None	4	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11294085	144030	0	None	1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmc.2017.11.035
	CHEMBL3751951	144030	0	None	1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmc.2017.11.035
	127028169	146268	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	2	6	4.4	CCc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794466	146268	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	2	6	4.4	CCc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	118352160	146207	0	None	7079	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793892	146207	0	None	7079	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	127027874	146141	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793045	146141	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	127027874	146141	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3793045	146141	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	127051656	147072	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805981	147072	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443871	158224	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	8	2	4	5.5	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(C)ccc(OCC(=O)O)c1C	nan
	CHEMBL3961932	158224	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	8	2	4	5.5	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(C)ccc(OCC(=O)O)c1C	nan
	89443827	150891	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	395	7	3	4	4.9	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3903635	150891	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	395	7	3	4	4.9	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	18376082	201702	0	None	-	1	Rat	9.0	pEC50	=	9.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL541517	201702	0	None	-	1	Rat	9.0	pEC50	=	9.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
	145977227	170786	0	None	-1	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4208379	170786	0	None	-1	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	10315	9700	28	None	1659	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	44230575	9700	28	None	1659	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	CHEMBL3707245	9700	28	None	1659	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	126495463	147085	0	None	69	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	6	2	6	3.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806130	147085	0	None	69	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	6	2	6	3.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	11502897	149571	0	None	43	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	149571	0	None	43	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855870	153058	0	None	467	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	153058	0	None	467	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855868	159323	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	159323	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855865	160056	0	None	35	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	160056	0	None	35	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	44230722	178508	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	489	10	2	7	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4467099	178508	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	489	10	2	7	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	11855868	159323	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	159323	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	127026953	146277	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	439	6	2	7	3.8	COc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794585	146277	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	439	6	2	7	3.8	COc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	1883	9856	75	None	-6	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	1916	9856	75	None	-6	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	5280360	9856	75	None	-6	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	913	9856	75	None	-6	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	CHEMBL548	9856	75	None	-6	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	DB00917	9856	75	None	-6	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	126495398	146989	0	None	416	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	403	7	2	6	3.9	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805044	146989	0	None	416	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	403	7	2	6	3.9	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443586	152463	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3916133	152463	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	118517489	150469	0	None	-18	3	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	CHEMBL3900245	150469	0	None	-18	3	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	92135977	159675	0	None	-141	4	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	CHEMBL3974652	159675	0	None	-141	4	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	8541	9718	2	None	-66069	4	Human	5.0	pEC50	=	5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	9824353	9718	2	None	-66069	4	Human	5.0	pEC50	=	5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL292964	9718	2	None	-66069	4	Human	5.0	pEC50	=	5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	59465571	153063	0	None	-1	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3920796	153063	0	None	-1	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	118517361	160149	0	None	-107	3	Human	6.0	pEC50	=	6.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	CHEMBL3978590	160149	0	None	-107	3	Human	6.0	pEC50	=	6.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	11955384	154316	0	None	33	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	360	8	2	3	4.4	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3930718	154316	0	None	33	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	360	8	2	3	4.4	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	45268715	202755	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559760	202755	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	16750455	158051	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	342	7	1	2	5.2	CC(C)(C)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3960352	158051	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	342	7	1	2	5.2	CC(C)(C)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	53259980	183148	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1cccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)c1	10.1021/acs.jmedchem.8b00808
	CHEMBL4566584	183148	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1cccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)c1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595789	183148	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1cccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)c1	10.1021/acs.jmedchem.8b00808
	126495507	146157	0	None	154	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	425	5	1	5	5.1	Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793167	146157	0	None	154	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	425	5	1	5	5.1	Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	71515776	161135	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	CC(Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3986985	161135	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	CC(Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	44304164	210013	0	None	-	1	Mouse	8.0	pEC50	=	8.0	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64483	210013	0	None	-	1	Mouse	8.0	pEC50	=	8.0	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	118517485	149528	0	None	-3	4	Human	8.0	pEC50	=	8.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	CHEMBL3892492	149528	0	None	-3	4	Human	8.0	pEC50	=	8.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	71515515	157783	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	369	7	2	3	4.7	O=C(O)COc1cccc(NCc2cc(-c3cccc(F)c3)ccc2F)c1	nan
	CHEMBL3958411	157783	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	369	7	2	3	4.7	O=C(O)COc1cccc(NCc2cc(-c3cccc(F)c3)ccc2F)c1	nan
	126495427	146244	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	422	5	2	5	4.7	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4csc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794185	146244	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	422	5	2	5	4.7	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4csc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	11955193	150362	0	None	10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	378	7	2	2	5.3	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3899346	150362	0	None	10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	378	7	2	2	5.3	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	155550016	183461	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	13	2	6	3.6	O=C(O)CNc1cccc(CN(CCCCCc2ccccc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4539881	183461	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	13	2	6	3.6	O=C(O)CNc1cccc(CN(CCCCCc2ccccc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4598324	183461	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	13	2	6	3.6	O=C(O)CNc1cccc(CN(CCCCCc2ccccc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	53260150	183311	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	9	2	6	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(C(F)(F)F)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4451786	183311	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	9	2	6	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(C(F)(F)F)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597091	183311	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	9	2	6	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(C(F)(F)F)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	11855590	151152	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3905811	151152	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855591	151214	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	151214	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	11855591	151214	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	151214	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	118517360	150753	0	None	-61	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
	CHEMBL3902700	150753	0	None	-61	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
	118517489	150469	0	None	-18	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	CHEMBL3900245	150469	0	None	-18	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	11955257	160665	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3983069	160665	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	118352211	146163	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793209	146163	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1016/j.bmcl.2016.03.110
	118352211	146163	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3793209	146163	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	126495491	147003	0	None	28	4	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	429	8	2	6	4.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805169	147003	0	None	28	4	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	429	8	2	6	4.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	127050452	147022	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(C(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805408	147022	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(C(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	53260293	182992	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.2	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CCC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4594090	182992	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.2	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CCC1	10.1021/acs.jmedchem.8b00808
	89443700	159365	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1F	nan
	CHEMBL3971868	159365	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1F	nan
	89444072	155723	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(-c2cccc(F)c2)ccc(F)c1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3941975	155723	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(-c2cccc(F)c2)ccc(F)c1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	44303952	107663	0	None	-	1	Mouse	6.9	pEC50	=	6.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL293697	107663	0	None	-	1	Mouse	6.9	pEC50	=	6.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	10270893	101003	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249954	101003	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	9885481	202162	0	None	14	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	CHEMBL551951	202162	0	None	14	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	11855325	151469	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	151469	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855325	151469	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	151469	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	127050451	146999	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805122	146999	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443781	156057	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2cc(-c3ccc(F)c(F)c3)ccc2F)c1F	nan
	CHEMBL3944601	156057	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2cc(-c3ccc(F)c(F)c3)ccc2F)c1F	nan
	10481859	81942	0	None	-67	2	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
	CHEMBL2036321	81942	0	None	-67	2	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
	44303627	209984	0	None	-	1	Mouse	5.9	pEC50	=	5.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64358	209984	0	None	-	1	Mouse	5.9	pEC50	=	5.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	134146425	155982	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3943966	155982	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	11855591	151214	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	151214	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	10291963	91483	0	None	-32	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL222715	91483	0	None	-32	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	127029402	146136	0	None	524	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	407	5	2	6	3.6	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793009	146136	0	None	524	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	407	5	2	6	3.6	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	24760052	157964	0	None	24	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3959769	157964	0	None	24	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	17751059	155047	0	None	3	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3936540	155047	0	None	3	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	89444124	150209	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(-c2ccccc2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3898152	150209	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(-c2ccccc2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	156014791	184363	0	None	-309	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	439	11	2	4	5.0	CCCCCC(O)CCc1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	CHEMBL4640635	184363	0	None	-309	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	439	11	2	4	5.0	CCCCCC(O)CCc1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	57464006	81943	0	None	-288	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036322	81943	0	None	-288	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	10269242	162354	0	None	-54	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL404413	162354	0	None	-54	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	59465577	149967	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3896183	149967	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	59465570	150037	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3896693	150037	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
	134143292	152006	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3912658	152006	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465574	152723	0	None	1	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
	CHEMBL3918084	152723	0	None	1	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
	59465601	156673	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3949271	156673	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	58681356	157150	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	7	3	4	3.9	O=C(O)COCC#CCC1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3953307	157150	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	7	3	4	3.9	O=C(O)COCC#CCC1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44442327	101234	0	None	-891	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251294	101234	0	None	-891	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	11855870	153058	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	153058	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855870	153058	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	153058	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	71515516	155085	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	387	7	2	3	4.8	O=C(O)COc1ccc(F)c(NCc2cccc(-c3cccc(F)c3)c2)c1F	nan
	CHEMBL3936868	155085	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	387	7	2	3	4.8	O=C(O)COc1ccc(F)c(NCc2cccc(-c3cccc(F)c3)c2)c1F	nan
	71516448	159339	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	3	4	4.7	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2F)c1F	nan
	CHEMBL3971730	159339	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	3	4	4.7	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2F)c1F	nan
	57893848	81944	0	None	-724	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036323	81944	0	None	-724	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	118517488	160490	0	None	-14	3	Human	6.8	pEC50	=	6.8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	CHEMBL3981554	160490	0	None	-14	3	Human	6.8	pEC50	=	6.8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	58708286	161123	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc([C@H](O)C2CCCCC2)cc1	nan
	CHEMBL3986874	161123	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc([C@H](O)C2CCCCC2)cc1	nan
	1929	8386	55	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	9890801	8386	55	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	CHEMBL563646	8386	55	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	DB12022	8386	55	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	89444254	149558	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2c(F)ccc(-c3cccc(F)c3)c2F)c1F	nan
	CHEMBL3892751	149558	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2c(F)ccc(-c3cccc(F)c3)c2F)c1F	nan
	89443784	149684	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	431	8	2	4	5.2	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3893770	149684	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	431	8	2	4	5.2	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	89444126	154166	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	403	7	3	4	4.6	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2)c1F	nan
	CHEMBL3929662	154166	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	403	7	3	4	4.6	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2)c1F	nan
	11955383	149311	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	2	3	4.2	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3890808	149311	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	2	3	4.2	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	53260155	178183	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.1	CC(C)C1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4462507	178183	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.1	CC(C)C1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	117703250	150417	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	C[C@@H](Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3899837	150417	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	C[C@@H](Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	89444132	150644	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	8	2	4	4.9	COc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3901709	150644	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	8	2	4	4.9	COc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	89443635	158683	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(OCC(=O)O)c(C)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3965998	158683	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(OCC(=O)O)c(C)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	57394893	78081	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957435	78081	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
	10291963	91483	0	None	-3801	4	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmc.2012.02.018
	CHEMBL222715	91483	0	None	-3801	4	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmc.2012.02.018
	57394893	78081	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957435	78081	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
	11855867	152761	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	152761	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855867	152761	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	152761	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	44455115	102337	0	None	-6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL257658	102337	0	None	-6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	1883	9856	75	None	-2	12	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	1916	9856	75	None	-2	12	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	5280360	9856	75	None	-2	12	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	913	9856	75	None	-2	12	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	CHEMBL548	9856	75	None	-2	12	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	DB00917	9856	75	None	-2	12	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	53259985	183256	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	497	10	2	6	4.3	COc1ccc(S(=O)(=O)N(Cc2ccc(C(C)(C)C)cc2)Cc2cccc(NCC(=O)O)n2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4548451	183256	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	497	10	2	6	4.3	COc1ccc(S(=O)(=O)N(Cc2ccc(C(C)(C)C)cc2)Cc2cccc(NCC(=O)O)n2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596602	183256	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	497	10	2	6	4.3	COc1ccc(S(=O)(=O)N(Cc2ccc(C(C)(C)C)cc2)Cc2cccc(NCC(=O)O)n2)cc1	10.1021/acs.jmedchem.8b00808
	44442332	101302	0	None	-97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251709	101302	0	None	-97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	127026952	146139	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	451	6	2	6	4.9	CC(C)c1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793020	146139	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	451	6	2	6	4.9	CC(C)c1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	59465581	150890	0	None	22	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3903611	150890	0	None	22	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	145966519	171178	0	None	15	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4213312	171178	0	None	15	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	44230429	183107	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	488	10	2	6	4.0	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4471378	183107	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	488	10	2	6	4.0	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595426	183107	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	488	10	2	6	4.0	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	89443841	152673	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	407	7	2	3	5.8	Cc1cc(-c2cccc(F)c2)cc(CNc2c(C)ccc(OCC(=O)O)c2C)c1C	nan
	CHEMBL3917749	152673	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	407	7	2	3	5.8	Cc1cc(-c2cccc(F)c2)cc(CNc2c(C)ccc(OCC(=O)O)c2C)c1C	nan
	89444231	152891	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3919482	152891	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	89443843	155576	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2ccc(F)c(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3940781	155576	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2ccc(F)c(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	89443583	157257	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1F	nan
	CHEMBL3954347	157257	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1F	nan
	66857988	170901	0	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	428	12	2	7	4.0	CCCCCC(C)(O)C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4209929	170901	0	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	428	12	2	7	4.0	CCCCCC(C)(O)C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	5283086	210089	24	None	-10	4	Mouse	8.7	pEC50	=	8.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
	CHEMBL64804	210089	24	None	-10	4	Mouse	8.7	pEC50	=	8.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
	118352285	146247	0	None	2398	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794226	146247	0	None	2398	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	18376196	201701	0	None	-	1	Rat	8.6	pEC50	=	8.6	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL541516	201701	0	None	-	1	Rat	8.6	pEC50	=	8.6	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
	70815687	183325	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	466	10	2	6	3.4	CC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4515583	183325	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	466	10	2	6	3.4	CC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597208	183325	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	466	10	2	6	3.4	CC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	138	9855	88	None	-1	10	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	149351	9855	88	None	-1	10	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	1882	9855	88	None	-1	10	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	5280723	9855	88	None	-1	10	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	CHEMBL495	9855	88	None	-1	10	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	DB00770	9855	88	None	-1	10	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	53260134	183041	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4466224	183041	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4594970	183041	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.8b00808
	53259986	183299	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccn2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4442505	183299	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccn2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596979	183299	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccn2)cc1	10.1021/acs.jmedchem.8b00808
	53259987	183277	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4591201	183277	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596748	183277	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	9807448	209951	0	None	1	2	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64246	209951	0	None	1	2	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	118352215	146195	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	403	5	2	6	3.8	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1C	10.1016/j.bmcl.2016.03.110
	CHEMBL3793797	146195	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	403	5	2	6	3.8	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1C	10.1016/j.bmcl.2016.03.110
	11855865	160056	0	None	35	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	160056	0	None	35	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	10126807	201877	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549869	201877	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11955273	159566	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	438	10	3	4	4.6	O=C(O)COCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3973644	159566	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	438	10	3	4	4.6	O=C(O)COCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	138107701	194243	46	None	-1348	7	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	10.1016/j.ejmech.2022.114154
	5311181	194243	46	None	-1348	7	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	10.1016/j.ejmech.2022.114154
	CHEMBL494	194243	46	None	-1348	7	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	10.1016/j.ejmech.2022.114154
	DB01088	194243	46	None	-1348	7	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	10.1016/j.ejmech.2022.114154
	59465583	150052	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	CHEMBL3896863	150052	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	11855594	159759	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	159759	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855594	159759	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	159759	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855871	153186	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	153186	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855871	153186	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	153186	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	54013831	153238	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3922151	153238	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	10363130	107812	1	None	-	1	Mouse	6.7	pEC50	=	6.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL294585	107812	1	None	-	1	Mouse	6.7	pEC50	=	6.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	9975502	101264	0	None	-14	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251504	101264	0	None	-14	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	24760052	157964	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3959769	157964	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	70667255	158253	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3962183	158253	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	72950089	157370	0	None	-4365	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL3955128	157370	0	None	-4365	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	11955180	158439	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2ccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)cc2)CCC1	nan
	CHEMBL3963968	158439	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2ccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)cc2)CCC1	nan
	10089562	161201	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL398948	161201	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	118352177	146190	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	1	6	4.8	CO[C@H]1C[C@@H]2O[C@@H](c3nc(C(=O)O)cs3)CC[C@@H]2[C@H]1COc1ccc(Cl)c(C)c1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793724	146190	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	1	6	4.8	CO[C@H]1C[C@@H]2O[C@@H](c3nc(C(=O)O)cs3)CC[C@@H]2[C@H]1COc1ccc(Cl)c(C)c1	10.1016/j.bmcl.2016.03.110
	127051064	147077	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3F)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806060	147077	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3F)O2)n1	10.1021/acsmedchemlett.5b00455
	89443417	158371	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2Cl)c1F	nan
	CHEMBL3963438	158371	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2Cl)c1F	nan
	44455046	102502	0	None	-8317	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL258332	102502	0	None	-8317	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
	56839536	149947	0	None	-141	7	Human	5.6	pEC50	=	5.6	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	604	15	2	7	5.1	CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1	nan
	CHEMBL3896035	149947	0	None	-141	7	Human	5.6	pEC50	=	5.6	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	604	15	2	7	5.1	CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1	nan
	57529188	153973	0	None	19	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	153973	0	None	19	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	89443813	158517	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3964577	158517	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	118517359	151174	0	None	-79	4	Human	7.6	pEC50	=	7.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	151174	0	None	-79	4	Human	7.6	pEC50	=	7.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	57384034	78082	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957436	78082	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
	57384034	78082	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957436	78082	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
	11955194	157782	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	2	2	5.5	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3958410	157782	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	2	2	5.5	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	58708282	159903	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	412	11	2	3	6.0	CCCC1([C@@H](O)c2cccc([C@H]3CCC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	CHEMBL3976452	159903	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	412	11	2	3	6.0	CCCC1([C@@H](O)c2cccc([C@H]3CCC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	58681352	161118	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
	CHEMBL3986829	161118	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
	126495360	147012	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805316	147012	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1	10.1021/acsmedchemlett.5b00455
	11855866	151380	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	151380	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	89443595	151739	5	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3910551	151739	5	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	57894053	81945	0	None	-208	2	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036324	81945	0	None	-208	2	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	118517359	151174	0	None	-79	4	Human	6.6	pEC50	=	6.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	151174	0	None	-79	4	Human	6.6	pEC50	=	6.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	126495420	147027	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	9	2	6	4.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805455	147027	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	9	2	6	4.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	11855324	149383	0	None	14	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	149383	0	None	14	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	71515514	154404	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3931335	154404	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	11955198	154021	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	10	3	3	5.8	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3928466	154021	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	10	3	3	5.8	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	155541719	183161	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	9	1	6	3.7	CN(CC(=O)O)c1cccc(CN(Cc2ccc(C(C)(C)C)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4519118	183161	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	9	1	6	3.7	CN(CC(=O)O)c1cccc(CN(Cc2ccc(C(C)(C)C)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595870	183161	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	9	1	6	3.7	CN(CC(=O)O)c1cccc(CN(Cc2ccc(C(C)(C)C)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	132836	66469	23	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL1722929	66469	23	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	155532079	178468	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	10	2	6	4.4	O=C(O)CNc1cccc(CN(Cc2ccc(C3CCCCC3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4466523	178468	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	10	2	6	4.4	O=C(O)CNc1cccc(CN(Cc2ccc(C3CCCCC3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	44455084	104643	0	None	-10	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
	CHEMBL272277	104643	0	None	-10	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
	59465581	150890	0	None	22	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3903611	150890	0	None	22	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	89443767	152490	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	409	8	2	4	5.2	COc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3916293	152490	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	409	8	2	4	5.2	COc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	89443716	153804	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3926711	153804	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	89443671	154616	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3932999	154616	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	89445501	159055	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)cc(F)c1C	nan
	CHEMBL3969269	159055	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)cc(F)c1C	nan
	89443873	160719	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	CHEMBL3983500	160719	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	127051062	147052	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805767	147052	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
	46931421	183042	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	7	3.6	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3s2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4476670	183042	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	7	3.6	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3s2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4594971	183042	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	7	3.6	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3s2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	126495424	147033	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1cccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)c1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805554	147033	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1cccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)c1	10.1021/acsmedchemlett.5b00455
	127052615	147048	0	None	181	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	401	6	2	6	3.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805693	147048	0	None	181	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	401	6	2	6	3.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	127027875	146194	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793786	146194	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1016/j.bmcl.2016.03.110
	127026954	146198	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	457	5	2	6	4.5	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1C(F)(F)F	10.1016/j.bmcl.2016.03.110
	CHEMBL3793809	146198	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	457	5	2	6	4.5	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1C(F)(F)F	10.1016/j.bmcl.2016.03.110
	127027875	146194	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3793786	146194	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	127052614	147004	0	None	40	6	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	415	7	2	6	4.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805176	147004	0	None	40	6	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	415	7	2	6	4.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	118517490	159934	0	None	-12	4	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	CHEMBL3976710	159934	0	None	-12	4	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	44230723	183284	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	490	10	2	8	2.8	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccnnc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4473407	183284	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	490	10	2	8	2.8	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccnnc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596867	183284	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	490	10	2	8	2.8	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccnnc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	134155748	157948	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959653	157948	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	145965248	171009	0	None	-9	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	439	10	2	6	5.4	CC(C)(C)CC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4211120	171009	0	None	-9	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	439	10	2	6	5.4	CC(C)(C)CC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	11855867	152761	0	None	10	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	152761	0	None	10	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	58681361	151459	0	None	-33	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	318	8	2	3	3.5	Cc1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3908432	151459	0	None	-33	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	318	8	2	3	3.5	Cc1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	44304181	210052	0	None	-1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64663	210052	0	None	-1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	58932683	82062	0	None	-1995	2	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
	CHEMBL2037289	82062	0	None	-1995	2	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
	11955178	160566	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	CHEMBL3982222	160566	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	44303980	174853	0	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse EP2- receptorEffective concentration which increases intracellular c-AMP production in mouse EP2- receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL432522	174853	0	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse EP2- receptorEffective concentration which increases intracellular c-AMP production in mouse EP2- receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
	1883	9856	75	None	-6	12	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	1916	9856	75	None	-6	12	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	5280360	9856	75	None	-6	12	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	913	9856	75	None	-6	12	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL548	9856	75	None	-6	12	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	DB00917	9856	75	None	-6	12	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	17757350	159533	0	None	870	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	CHEMBL3973347	159533	0	None	870	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	89444121	154210	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	CHEMBL3929987	154210	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	45271237	201878	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549870	201878	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	66858036	170670	0	None	-93	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	468	10	2	7	4.8	C[C@@H]1OC(=O)N(CCSc2nc(C(=O)O)cs2)[C@H]1/C=C/CC(C)(O)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4207054	170670	0	None	-93	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	468	10	2	7	4.8	C[C@@H]1OC(=O)N(CCSc2nc(C(=O)O)cs2)[C@H]1/C=C/CC(C)(O)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	59465599	153339	0	None	1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	12	2	3	6.2	CCCC1(C(O)c2cccc([C@H]3CCC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	CHEMBL3922856	153339	0	None	1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	12	2	3	6.2	CCCC1(C(O)c2cccc([C@H]3CCC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	59465600	158477	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3964261	158477	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	58681358	157438	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	420	10	2	2	6.3	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(CC3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3955642	157438	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	420	10	2	2	6.3	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(CC3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44442331	101265	0	None	-346	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251505	101265	0	None	-346	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	44230430	183149	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	506	10	2	6	4.2	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(F)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4449902	183149	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	506	10	2	6	4.2	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(F)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595790	183149	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	506	10	2	6	4.2	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(F)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	71515518	149584	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3892911	149584	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	89443584	151955	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	CHEMBL3912323	151955	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	118517361	160149	0	None	-107	3	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	CHEMBL3978590	160149	0	None	-107	3	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	155542681	183379	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	7	3.7	CC(C)(C)c1ccc(CN(Cc2csc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4521659	183379	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	7	3.7	CC(C)(C)c1ccc(CN(Cc2csc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597685	183379	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	7	3.7	CC(C)(C)c1ccc(CN(Cc2csc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	11955156	155233	1	None	-2	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	3	4	4.9	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	CHEMBL3937945	155233	1	None	-2	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	3	4	4.9	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	118689427	158631	0	None	-8	2	Human	7.4	pEC50	=	7.4	Functional	cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
	CHEMBL3965497	158631	0	None	-8	2	Human	7.4	pEC50	=	7.4	Functional	cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
	57893982	81939	0	None	-25	2	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	CHEMBL2036318	81939	0	None	-25	2	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	11955259	153537	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	9	3	4	4.4	O=C(O)COC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3924405	153537	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	9	3	4	4.4	O=C(O)COC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	57529188	153973	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	153973	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	57529188	153973	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	153973	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	44303626	174961	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL433249	174961	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	56839344	158830	0	None	-12882	8	Human	5.4	pEC50	=	5.4	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	656	13	2	9	5.1	O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F	nan
	CHEMBL3967284	158830	0	None	-12882	8	Human	5.4	pEC50	=	5.4	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	656	13	2	9	5.1	O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F	nan
	11955196	151200	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	9	3	3	5.6	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3906280	151200	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	9	3	3	5.6	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44444722	101031	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
	CHEMBL250153	101031	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
	17751059	155047	0	None	3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3936540	155047	0	None	3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	17757350	159533	0	None	870	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	CHEMBL3973347	159533	0	None	870	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	89444221	151058	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	430	8	3	4	3.9	NC(=O)c1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3904996	151058	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	430	8	3	4	3.9	NC(=O)c1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	53259981	183129	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	467	9	2	5	4.3	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4456588	183129	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	467	9	2	5	4.3	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595646	183129	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	467	9	2	5	4.3	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.8b00808
	53259984	183314	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4447271	183314	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597100	183314	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00808
	53260154	177910	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	11	2	6	3.8	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4458330	177910	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	11	2	6	3.8	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	11955276	157530	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
	CHEMBL3956391	157530	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
	22246893	202731	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559561	202731	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11855588	154135	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3929446	154135	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	11855588	154135	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3929446	154135	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	22246765	201977	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL550619	201977	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	22246895	202343	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL554823	202343	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11855866	151380	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	151380	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855866	151380	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	151380	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	57564500	157989	0	None	2	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959926	157989	0	None	2	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	44230997	177316	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	479	10	2	9	1.9	O=C(O)CNc1cccc(CN(Cc2ccc(-n3cncn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4449855	177316	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	479	10	2	9	1.9	O=C(O)CNc1cccc(CN(Cc2ccc(-n3cncn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	44304199	107594	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL293242	107594	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	9821171	104642	0	None	-14454	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL272276	104642	0	None	-14454	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
	10223499	203120	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562411	203120	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11855324	149383	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	149383	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855324	149383	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	149383	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	53259982	183214	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2F)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4561017	183214	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2F)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596258	183214	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2F)cc1	10.1021/acs.jmedchem.8b00808
	89443872	152619	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	437	7	2	3	6.0	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	CHEMBL3917219	152619	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	437	7	2	3	6.0	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	44304124	109400	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL304225	109400	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	11955297	156666	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	416	10	3	4	4.8	O=C(O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	CHEMBL3949225	156666	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	416	10	3	4	4.8	O=C(O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	22246983	202641	0	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL558671	202641	0	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	23729077	84993	31	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	520	11	0	8	4.0	CC(C)OC(=O)COc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)c1	nan
	CHEMBL2105692	84993	31	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	520	11	0	8	4.0	CC(C)OC(=O)COc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)c1	nan
	57894063	81940	0	None	-301	2	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	CHEMBL2036319	81940	0	None	-301	2	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	156010583	183857	0	None	-162	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	451	10	2	4	5.4	CCCCCC(C)(O)/C=C/c1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	CHEMBL4633041	183857	0	None	-162	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	451	10	2	4	5.4	CCCCCC(C)(O)/C=C/c1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	45271238	202420	0	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL556333	202420	0	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	59465587	151968	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
	CHEMBL3912391	151968	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
	11955315	150569	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	CC(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3901088	150569	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	CC(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	11955256	150094	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	424	9	2	4	5.4	COC(=O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C(C)(C)C)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3897181	150094	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	424	9	2	4	5.4	COC(=O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C(C)(C)C)cc2)[C@H](O)C[C@H]1Cl	nan
	16725337	156380	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	156380	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	16725337	156380	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	156380	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	89443809	154924	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	427	8	2	4	5.3	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	CHEMBL3935521	154924	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	427	8	2	4	5.3	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	89443631	155444	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	CHEMBL3939716	155444	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	127050450	147078	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806076	147078	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	57395059	76249	0	None	-11	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL1933725	76249	0	None	-11	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1021/acsmedchemlett.5b00455
	44229605	183433	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	452	9	2	7	3.1	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3o2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4470479	183433	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	452	9	2	7	3.1	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3o2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4598070	183433	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	452	9	2	7	3.1	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3o2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	89443989	155447	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(OCC(=O)O)c(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3939740	155447	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(OCC(=O)O)c(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	44444714	100913	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249341	100913	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	59465588	150304	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3898887	150304	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465575	151845	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
	CHEMBL3911438	151845	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
	59465595	152201	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
	CHEMBL3914108	152201	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
	59465592	156481	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3947785	156481	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
	59465590	157724	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3957958	157724	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465584	158209	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
	CHEMBL3961847	158209	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
	11855325	151469	0	None	19	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	151469	0	None	19	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11955233	152371	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	8	3	3	4.3	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3915426	152371	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	8	3	3	4.3	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	11855593	153612	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL3924987	153612	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
	89444078	152852	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(F)cc(-c3cccc(F)c3)c2)c1F	nan
	CHEMBL3919144	152852	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(F)cc(-c3cccc(F)c3)c2)c1F	nan
	11955406	152882	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3919393	152882	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	11955294	151546	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3909111	151546	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
	44303889	209996	0	None	-	1	Mouse	7.3	pEC50	=	7.3	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64423	209996	0	None	-	1	Mouse	7.3	pEC50	=	7.3	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
	11955179	153260	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	450	12	3	3	6.2	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	CHEMBL3922332	153260	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	450	12	3	3	6.2	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	11855588	154135	0	None	12	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3929446	154135	0	None	12	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	126495432	146102	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4coc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3792668	146102	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4coc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	71515517	154861	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)c(F)c(-c2cccc(F)c2)c1	nan
	CHEMBL3934986	154861	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)c(F)c(-c2cccc(F)c2)c1	nan
	56839343	151057	0	None	-147	6	Human	5.3	pEC50	=	5.3	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	642	14	2	8	5.4	COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1	nan
	CHEMBL3904989	151057	0	None	-147	6	Human	5.3	pEC50	=	5.3	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	642	14	2	8	5.4	COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1	nan
	45266955	202424	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
	CHEMBL556416	202424	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
	57564500	157989	0	None	2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959926	157989	0	None	2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	44303723	209714	0	None	-	1	Mouse	6.2	pEC50	=	6.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL62885	209714	0	None	-	1	Mouse	6.2	pEC50	=	6.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
	45269576	202762	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559820	202762	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	9863804	100873	0	None	-120	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249136	100873	0	None	-120	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	89444271	158687	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1C	nan
	CHEMBL3966050	158687	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1C	nan
	53259983	183080	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(F)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4587628	183080	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(F)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595199	183080	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(F)c2)cc1	10.1021/acs.jmedchem.8b00808
	2720	10626	59	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	5820	10626	59	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	6918140	10626	59	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	CHEMBL1237119	10626	59	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	DB00374	10626	59	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	127052577	147038	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(Cl)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805596	147038	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(Cl)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	67082722	171407	0	None	2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4216182	171407	0	None	2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	8541	9718	2	None	-66069	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	9824353	9718	2	None	-66069	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL292964	9718	2	None	-66069	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	155527947	183313	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4460294	183313	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597099	183313	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00808
	11955157	159422	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	430	12	3	4	5.1	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	CHEMBL3972401	159422	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	430	12	3	4	5.1	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	56649302	159445	0	None	-169	6	Human	5.2	pEC50	=	5.2	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	630	13	2	7	5.5	O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	CHEMBL3972583	159445	0	None	-169	6	Human	5.2	pEC50	=	5.2	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	630	13	2	7	5.5	O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	155539238	183260	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	6	4.0	CC(C)(C)C1CCC(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4514124	183260	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	6	4.0	CC(C)(C)C1CCC(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596631	183260	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	6	4.0	CC(C)(C)C1CCC(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)CC1	10.1021/acs.jmedchem.8b00808
	71516449	156215	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3945923	156215	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	127050766	146991	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805075	146991	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443614	157368	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	393	7	2	3	5.5	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3955120	157368	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	393	7	2	3	5.5	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	127052613	146984	0	None	-10	6	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	7	3	7	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3804978	146984	0	None	-10	6	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	7	3	7	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	11955236	153234	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3922121	153234	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	44303711	109129	0	None	-	1	Mouse	7.2	pEC50	=	7.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL303763	109129	0	None	-	1	Mouse	7.2	pEC50	=	7.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	67245477	151661	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
	CHEMBL3909989	151661	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
	24760055	150666	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	CHEMBL3901873	150666	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	24760055	150666	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	CHEMBL3901873	150666	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	89443736	158133	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3961188	158133	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	12521	8978	0	None	-23988	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	72722131	8978	0	None	-23988	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	CHEMBL3918816	8978	0	None	-23988	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	11955234	158996	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3968751	158996	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44230431	183432	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	522	10	2	6	4.7	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(Cl)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4531171	183432	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	522	10	2	6	4.7	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(Cl)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4598069	183432	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	522	10	2	6	4.7	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(Cl)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	118517483	151049	0	None	-22	3	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	CHEMBL3904946	151049	0	None	-22	3	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	11855590	151152	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3905811	151152	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855590	151152	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3905811	151152	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	134147021	156803	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
	CHEMBL3950412	156803	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
	11955255	153035	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3920560	153035	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	92135977	159675	0	None	-141	4	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	CHEMBL3974652	159675	0	None	-141	4	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	5819	7799	29	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at EP2 receptor (unknown origin) by cAMP assayAgonist activity at EP2 receptor (unknown origin) by cAMP assay	ChEMBL	333	4	1	5	4.0	CCOC(=O)c1c(sc2c1CCCCC2)NC(=O)c1ccco1	10.1021/jm401431x
	673766	7799	29	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at EP2 receptor (unknown origin) by cAMP assayAgonist activity at EP2 receptor (unknown origin) by cAMP assay	ChEMBL	333	4	1	5	4.0	CCOC(=O)c1c(sc2c1CCCCC2)NC(=O)c1ccco1	10.1021/jm401431x
	CHEMBL1578948	7799	29	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at EP2 receptor (unknown origin) by cAMP assayAgonist activity at EP2 receptor (unknown origin) by cAMP assay	ChEMBL	333	4	1	5	4.0	CCOC(=O)c1c(sc2c1CCCCC2)NC(=O)c1ccco1	10.1021/jm401431x
	11855871	153186	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	153186	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855594	159759	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	159759	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11502897	149571	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	149571	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11502897	149571	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	149571	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	89443779	155518	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	399	7	3	4	4.7	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3940318	155518	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	399	7	3	4	4.7	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	89443711	157758	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2cc(F)cc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3958279	157758	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2cc(F)cc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	118517483	151049	0	None	-22	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	CHEMBL3904946	151049	0	None	-22	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	118517359	151174	0	None	-79	4	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	151174	0	None	-79	4	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	118517488	160490	0	None	-14	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	CHEMBL3981554	160490	0	None	-14	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	44442327	101234	0	None	-891	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL251294	101234	0	None	-891	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	11955358	159861	0	None	-11	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3976116	159861	0	None	-11	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
	155521507	183228	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	10	2	6	4.1	CC(C)(C)c1ccc(CN(Cc2cccc(NCCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4451941	183228	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	10	2	6	4.1	CC(C)(C)c1ccc(CN(Cc2cccc(NCCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596396	183228	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	10	2	6	4.1	CC(C)(C)c1ccc(CN(Cc2cccc(NCCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	56839342	155786	0	None	-83	7	Human	6.1	pEC50	=	6.1	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	646	13	2	7	6.0	O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	CHEMBL3942394	155786	0	None	-83	7	Human	6.1	pEC50	=	6.1	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	646	13	2	7	6.0	O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	58932678	82063	0	None	-301	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
	CHEMBL2037290	82063	0	None	-301	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
	22246956	203098	0	None	-	1	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562291	203098	0	None	-	1	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	69753740	147000	0	None	-2454	5	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	390	9	3	5	2.8	O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805134	147000	0	None	-2454	5	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	390	9	3	5	2.8	O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1	10.1021/acsmedchemlett.5b00455
	134155748	157948	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959653	157948	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	89443669	153990	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	7	3	4	4.9	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1O	nan
	CHEMBL3928263	153990	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	7	3	4	4.9	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1O	nan
	89443662	159667	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3974557	159667	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	1883	9856	75	None	-6	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	1916	9856	75	None	-6	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	5280360	9856	75	None	-6	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	913	9856	75	None	-6	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL548	9856	75	None	-6	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	DB00917	9856	75	None	-6	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	56835070	76246	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933722	76246	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	56835070	76246	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL1933722	76246	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
	51036042	183120	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	405	8	2	5	2.8	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(C)(=O)=O)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4554216	183120	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	405	8	2	5	2.8	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(C)(=O)=O)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595541	183120	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	405	8	2	5	2.8	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(C)(=O)=O)cc1	10.1021/acs.jmedchem.8b00808
	66857975	171267	0	None	-10	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	454	10	2	7	4.4	CC(O)(C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4214346	171267	0	None	-10	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	454	10	2	7	4.4	CC(O)(C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	11955133	152427	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	374	8	1	4	4.5	COC(=O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(C)(C)C)cc1	nan
	CHEMBL3915820	152427	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	374	8	1	4	4.5	COC(=O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(C)(C)C)cc1	nan
	9820676	201824	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549461	201824	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	89444029	155873	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(OCC(=O)O)c(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3943109	155873	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(OCC(=O)O)c(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	122180297	128425	0	None	4466	2	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586362	128425	0	None	4466	2	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	122180261	128391	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586324	128391	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
	122180274	128401	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586337	128401	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180288	128416	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586352	128416	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180250	128380	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586313	128380	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
	122180267	128395	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586330	128395	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180251	128381	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586314	128381	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
	122180273	128400	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586336	128400	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	1987175	10566	31	None	1	5	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assayAntagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay	ChEMBL	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	10.1021/ml400112h
	9283	10566	31	None	1	5	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assayAntagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay	ChEMBL	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	10.1021/ml400112h
	CHEMBL1372836	10566	31	None	1	5	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assayAntagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay	ChEMBL	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	10.1021/ml400112h
	122180270	128397	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586333	128397	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180282	128409	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586345	128409	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180295	128422	0	None	281	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586359	128422	0	None	281	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	122180296	128424	0	None	758	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586361	128424	0	None	758	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	122180265	128394	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586328	128394	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180276	128403	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586339	128403	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180289	128417	0	None	7	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586353	128417	0	None	7	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	56927669	128423	0	None	-2	4	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	128423	0	None	-2	4	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	30897313	128376	0	None	-2	5	Rat	6.5	pIC50	=	6.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	128376	0	None	-2	5	Rat	6.5	pIC50	=	6.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	42484632	128377	5	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586310	128377	5	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
	122180275	128402	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586338	128402	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180278	128405	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586341	128405	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180286	128413	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586349	128413	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	56927669	128423	0	None	2	4	Mouse	8.4	pIC50	=	8.4	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	128423	0	None	2	4	Mouse	8.4	pIC50	=	8.4	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	122180283	128410	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586346	128410	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180280	128407	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586343	128407	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180263	128392	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586326	128392	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	56927669	128423	0	None	-3	4	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	128423	0	None	-3	4	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	122180252	128382	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586315	128382	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
	122180284	128411	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586347	128411	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	30897313	128376	0	None	2	5	Mouse	7.2	pIC50	=	7.2	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	128376	0	None	2	5	Mouse	7.2	pIC50	=	7.2	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	30897313	128376	0	None	-2	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	128376	0	None	-2	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180272	128399	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586335	128399	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180279	128406	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586342	128406	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180249	128379	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586312	128379	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
	30956824	128378	4	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586311	128378	4	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
	122180277	128404	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586340	128404	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	44365207	47470	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	489	5	2	6	3.8	O=C(CCS(=O)(=O)Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	CHEMBL148449	47470	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	489	5	2	6	3.8	O=C(CCS(=O)(=O)Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	38191	16685	16	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	407	4	2	3	4.6	O=C(CCCCCl)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	CHEMBL114395	16685	16	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	407	4	2	3	4.6	O=C(CCCCCl)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	44365227	128764	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	473	5	2	5	4.1	O=C(CC[S+]([O-])Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	CHEMBL359231	128764	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	473	5	2	5	4.1	O=C(CC[S+]([O-])Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	1924	10315	39	None	-	0	Human	8.1	pKd	=	8.1	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	457	5	2	5	5.1	O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1	10.1016/0960-894X(94)80027-8
	9933831	10315	39	None	-	0	Human	8.1	pKd	=	8.1	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	457	5	2	5	5.1	O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1	10.1016/0960-894X(94)80027-8
	CHEMBL358653	10315	39	None	-	0	Human	8.1	pKd	=	8.1	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	457	5	2	5	5.1	O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1	10.1016/0960-894X(94)80027-8
	119461	7108	72	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at EP2 receptor (unknown origin) by functional cAMP assayAntagonist activity at EP2 receptor (unknown origin) by functional cAMP assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	1896	7108	72	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at EP2 receptor (unknown origin) by functional cAMP assayAntagonist activity at EP2 receptor (unknown origin) by functional cAMP assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	CHEMBL1317823	7108	72	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at EP2 receptor (unknown origin) by functional cAMP assayAntagonist activity at EP2 receptor (unknown origin) by functional cAMP assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	9817405	172182	5	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/s0960-894x(01)00056-7
	CHEMBL423815	172182	5	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/s0960-894x(01)00056-7
	10402929	64317	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00056-7
	CHEMBL166351	64317	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00056-7
	44377464	126863	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl	10.1016/s0960-894x(01)00056-7
	CHEMBL350832	126863	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl	10.1016/s0960-894x(01)00056-7
	9817292	64001	0	None	-	0	Human	4.4	pKi	=	4.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	284	5	1	2	4.1	CSc1ccc(Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/s0960-894x(01)00056-7
	CHEMBL165010	64001	0	None	-	0	Human	4.4	pKi	=	4.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	284	5	1	2	4.1	CSc1ccc(Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/s0960-894x(01)00056-7
	10483360	206007	28	None	-	4	Human	4.4	pKi	=	4.4	Functional	Inhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP productionInhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP production	ChEMBL	580	12	3	6	5.8	CCCCNC(=O)c1ccc(Oc2ccc(CC(=O)O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1	10.1016/j.bmcl.2009.09.052
	CHEMBL589973	206007	28	None	-	4	Human	4.4	pKi	=	4.4	Functional	Inhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP productionInhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP production	ChEMBL	580	12	3	6	5.8	CCCCNC(=O)c1ccc(Oc2ccc(CC(=O)O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1	10.1016/j.bmcl.2009.09.052
	138	9855	88	None	-4	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	149351	9855	88	None	-4	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1882	9855	88	None	-4	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	5280723	9855	88	None	-4	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	CHEMBL495	9855	88	None	-4	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	DB00770	9855	88	None	-4	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	44230999	174225	26	None	-	1	Human	8.1	pEC50	=	8.1	Functional	activity measured for the active metabolite (omidenepag)activity measured for the active metabolite (omidenepag)	Drug Central	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	None
	CHEMBL4297666	174225	26	None	-	1	Human	8.1	pEC50	=	8.1	Functional	activity measured for the active metabolite (omidenepag)activity measured for the active metabolite (omidenepag)	Drug Central	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	None
	DB15071	174225	26	None	-	1	Human	8.1	pEC50	=	8.1	Functional	activity measured for the active metabolite (omidenepag)activity measured for the active metabolite (omidenepag)	Drug Central	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	None
	1929	8386	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	9890801	8386	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	CHEMBL563646	8386	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	DB12022	8386	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	1883	9856	75	None	-2	12	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1916	9856	75	None	-2	12	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5280360	9856	75	None	-2	12	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	913	9856	75	None	-2	12	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	CHEMBL548	9856	75	None	-2	12	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	DB00917	9856	75	None	-2	12	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1929	8386	55	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	9890801	8386	55	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	CHEMBL563646	8386	55	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	DB12022	8386	55	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	18376177	10525	50	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	5816	10525	50	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	CHEMBL2107783	10525	50	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	DB12623	10525	50	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	18376177	10525	50	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	5816	10525	50	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	CHEMBL2107783	10525	50	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	DB12623	10525	50	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	12520	10568	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	35187419
	12520	10568	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	36654746
	155128767	10568	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	35187419
	155128767	10568	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	36654746
	10603	10564	0	None	537	3	Human	8.0	pKB	=	8.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	400	6	3	5	4.0	Cc1cc(Nc2ncc(cn2)C(=O)NCCc2c(C)[nH]c3c2cccc3)nc(c1)C	31904232
	145996528	10564	0	None	537	3	Human	8.0	pKB	=	8.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	400	6	3	5	4.0	Cc1cc(Nc2ncc(cn2)C(=O)NCCc2c(C)[nH]c3c2cccc3)nc(c1)C	31904232
	CHEMBL4552900	10564	0	None	537	3	Human	8.0	pKB	=	8.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	400	6	3	5	4.0	Cc1cc(Nc2ncc(cn2)C(=O)NCCc2c(C)[nH]c3c2cccc3)nc(c1)C	31904232
	1987175	10566	31	None	1	5	Human	8.1	pKB	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	23914286
	9283	10566	31	None	1	5	Human	8.1	pKB	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	23914286
	CHEMBL1372836	10566	31	None	1	5	Human	8.1	pKB	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	23914286
	25114442	9835	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	25114442	9835	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	5817	9835	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	5817	9835	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	CHEMBL3286797	9835	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	CHEMBL3286797	9835	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	DB12024	9835	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	DB12024	9835	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	25114442	9835	56	None	1	3	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	5817	9835	56	None	1	3	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	CHEMBL3286797	9835	56	None	1	3	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	DB12024	9835	56	None	1	3	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	46213069	9837	0	None	-	1	Human	8.5	pKB	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	23786281
	8538	9837	0	None	-	1	Human	8.5	pKB	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	23786281
	CHEMBL5285583	9837	0	None	-	1	Human	8.5	pKB	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	23786281
	8546	10567	0	None	-	1	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	377	9	1	3	4.5	CCN(c1ccc(cc1)CC(=O)NCCCn1c(C)cc2c1cccc2)CC	24937185
	91827368	10567	0	None	-	1	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	377	9	1	3	4.5	CCN(c1ccc(cc1)CC(=O)NCCCn1c(C)cc2c1cccc2)CC	24937185
	5818	10565	47	None	1096	2	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	22323596
	5886965	10565	47	None	1096	2	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	22323596
	CHEMBL1368005	10565	47	None	1096	2	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	22323596

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	11855868	159323	0	None	-	1	Human	9.8	pEC50	=	9.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	159323	0	None	-	1	Human	9.8	pEC50	=	9.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	127037150	144338	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	12	2	6	4.1	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	CHEMBL3754586	144338	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	12	2	6	4.1	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	16725337	156380	0	None	-	1	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	156380	0	None	-	1	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	59554827	144071	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	11	2	6	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	CHEMBL3752377	144071	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	11	2	6	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	11502897	149571	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	149571	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855865	160056	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	160056	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855870	153058	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	153058	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	1932	9716	5	None	1	6	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	5311228	9716	5	None	1	6	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	CHEMBL3286796	9716	5	None	1	6	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	90054482	150695	0	None	-	0	Human	6.0	pEC50	=	6	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	463	10	2	4	4.4	C[C@@H](Cc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3902065	150695	0	None	-	0	Human	6.0	pEC50	=	6	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	463	10	2	4	4.4	C[C@@H](Cc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	90054490	158969	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3968443	158969	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	127051063	147100	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806284	147100	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
	11855590	151152	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3905811	151152	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	90054450	150554	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	493	13	2	4	5.4	C[C@@H](CCCc1ccccc1)[C@H](O)CC[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3900979	150554	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	493	13	2	4	5.4	C[C@@H](CCCc1ccccc1)[C@H](O)CC[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	11855591	151214	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	151214	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	72948479	159812	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3975743	159812	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	70667255	158253	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3962183	158253	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	90054430	156143	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	505	13	2	4	5.6	C[C@@H](CCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3945327	156143	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	505	13	2	4	5.6	C[C@@H](CCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	5283056	209639	34	None	-	0	Human	7.8	pEC50	=	7.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O	nan
	CHEMBL62570	209639	34	None	-	0	Human	7.8	pEC50	=	7.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O	nan
	66858111	144229	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	488	11	2	7	4.5	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCc3ccccc3)CCC2)n1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753622	144229	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	488	11	2	7	4.5	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCc3ccccc3)CCC2)n1	10.1016/j.bmcl.2015.12.039
	72950425	149828	0	None	-	1	Human	5.8	pEC50	=	5.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	419	8	2	3	3.5	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
	CHEMBL3895047	149828	0	None	-	1	Human	5.8	pEC50	=	5.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	419	8	2	3	3.5	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
	11328569	144246	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	COCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753788	144246	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	COCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	11855324	149383	0	None	-	1	Human	6.7	pEC50	=	6.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	149383	0	None	-	1	Human	6.7	pEC50	=	6.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	72950929	153360	0	None	-	1	Human	5.7	pEC50	=	5.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	395	10	2	3	3.7	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
	CHEMBL3923027	153360	0	None	-	1	Human	5.7	pEC50	=	5.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	395	10	2	3	3.7	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
	1883	9856	75	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	1916	9856	75	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	5280360	9856	75	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	913	9856	75	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	CHEMBL548	9856	75	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	DB00917	9856	75	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	126495400	146099	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3792632	146099	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	127026955	146228	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794016	146228	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
	18376177	10525	50	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	5816	10525	50	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	CHEMBL2107783	10525	50	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	DB12623	10525	50	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	11294085	144030	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmcl.2015.12.039
	CHEMBL3751951	144030	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmcl.2015.12.039
	59554822	144172	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	440	11	2	7	4.0	CCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753221	144172	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	440	11	2	7	4.0	CCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	127051062	147052	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805767	147052	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
	72950089	157370	0	None	-1621	3	Human	6.7	pEC50	=	6.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	nan
	CHEMBL3955128	157370	0	None	-1621	3	Human	6.7	pEC50	=	6.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	nan
	66857670	144179	0	None	-	1	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	436	9	2	7	3.3	CC#CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753268	144179	0	None	-	1	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	436	9	2	7	3.3	CC#CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	57529188	153973	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	153973	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855866	151380	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	151380	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855325	151469	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	151469	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855324	149383	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	149383	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	127026652	144260	0	None	-	1	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	CCOCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753898	144260	0	None	-	1	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	CCOCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	127026956	146204	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793862	146204	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	9807448	209951	0	None	1	4	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
	CHEMBL64246	209951	0	None	1	4	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
	11855867	152761	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	152761	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	1892	7534	20	None	-2	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	25886893	7534	20	None	-2	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	CHEMBL1628262	7534	20	None	-2	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	72948663	152512	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	415	11	2	4	4.1	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3916499	152512	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	415	11	2	4	4.1	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	5311035	104579	29	None	-4	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
	CHEMBL271896	104579	29	None	-4	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
	1883	9856	75	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	1916	9856	75	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	5280360	9856	75	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	913	9856	75	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	CHEMBL548	9856	75	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	DB00917	9856	75	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	66857738	144078	0	None	-	1	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	468	10	2	7	4.7	CC(C)(C)CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	CHEMBL3752435	144078	0	None	-	1	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	468	10	2	7	4.7	CC(C)(C)CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	127050451	146999	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805122	146999	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	1929	8386	55	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	9890801	8386	55	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	CHEMBL563646	8386	55	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	DB12022	8386	55	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	11362836	144074	0	None	-	1	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	446	12	2	7	3.8	CC(C)(CCCCF)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	CHEMBL3752406	144074	0	None	-	1	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	446	12	2	7	3.8	CC(C)(CCCCF)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	11855325	151469	0	None	-	1	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	151469	0	None	-	1	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855593	153612	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL3924987	153612	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
	11855588	154135	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3929446	154135	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	5283086	210089	24	None	-	5	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	CHEMBL64804	210089	24	None	-	5	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	11156167	144298	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	494	11	2	7	5.2	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCC3CCCCC3)CCC2)n1	10.1016/j.bmcl.2015.12.039
	CHEMBL3754197	144298	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	494	11	2	7	5.2	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCC3CCCCC3)CCC2)n1	10.1016/j.bmcl.2015.12.039
	90054537	155182	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3937596	155182	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	127051656	147072	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805981	147072	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	59554824	144253	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	428	11	2	7	3.9	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753853	144253	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	428	11	2	7	3.9	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	90054519	158765	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	477	11	2	4	4.8	C[C@@H](CCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3966743	158765	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	477	11	2	4	4.8	C[C@@H](CCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	72948294	156736	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	439	9	2	4	4.0	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3949856	156736	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	439	9	2	4	4.0	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	90054392	149696	0	None	-	0	Human	4.1	pEC50	=	4.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3893847	149696	0	None	-	0	Human	4.1	pEC50	=	4.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	11855871	153186	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	153186	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855594	159759	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	159759	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	127027874	146141	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3793045	146141	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	127027874	146141	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793045	146141	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	10339756	149863	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	CHEMBL3895324	149863	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	118689427	158631	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
	CHEMBL3965497	158631	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
	56927669	128423	0	None	-	0	Mouse	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	128423	0	None	-	0	Mouse	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	56927669	128423	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	128423	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	10315	9700	28	None	-	1	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	44230575	9700	28	None	-	1	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	CHEMBL3707245	9700	28	None	-	1	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	122180251	128381	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586314	128381	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
	122180259	128389	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	479	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(S(C)(=O)=O)cc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586322	128389	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	479	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(S(C)(=O)=O)cc1)C2	10.1021/acs.jmedchem.5b00567
	122180261	128391	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586324	128391	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
	122180282	128409	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586345	128409	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	30897313	128376	0	None	-	0	Mouse	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	128376	0	None	-	0	Mouse	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	30897313	128376	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	128376	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180253	128383	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	401	4	0	4	6.0	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586316	128383	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	401	4	0	4	6.0	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccc1)C2	10.1021/acs.jmedchem.5b00567
	122180271	128398	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccc(Cl)cc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586334	128398	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccc(Cl)cc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	44564990	199429	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	538	6	1	5	5.7	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(F)c3)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL521777	199429	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	538	6	1	5	5.7	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(F)c3)cccc21	10.1016/j.bmcl.2008.12.112
	122180276	128403	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586339	128403	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180285	128412	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	372	3	0	4	5.4	c1cncc(CN2CCOc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586348	128412	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	372	3	0	4	5.4	c1cncc(CN2CCOc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	44409693	172877	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	429	11	2	4	4.3	CCc1ccc(CC(O)CC[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)cc1	10.1016/j.bmcl.2006.01.018
	CHEMBL425950	172877	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	429	11	2	4	4.3	CCc1ccc(CC(O)CC[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)cc1	10.1016/j.bmcl.2006.01.018
	122180269	128396	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccccc2Cl)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586332	128396	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccccc2Cl)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	44409907	83825	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2ccc(F)cc2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL207237	83825	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2ccc(F)cc2)s1	10.1016/j.bmcl.2006.01.018
	44570000	185429	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	544	7	2	5	6.2	O=C(COc1cccc2[nH]cc(Cc3ccc4ccccc4c3)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
	CHEMBL467632	185429	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	544	7	2	5	6.2	O=C(COc1cccc2[nH]cc(Cc3ccc4ccccc4c3)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
	44409739	146438	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2-c2ccccc2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL379785	146438	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2-c2ccccc2)s1	10.1016/j.bmcl.2006.01.018
	44157014	199396	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	518	6	1	5	5.9	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL521609	199396	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	518	6	1	5	5.9	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21	10.1016/j.bmcl.2008.12.112
	58905349	163057	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	400	6	2	4	4.3	O=C(O)c1ccc(CNC(=O)c2cc(Cl)cnc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4065183	163057	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	400	6	2	4	4.3	O=C(O)c1ccc(CNC(=O)c2cc(Cl)cnc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4552554	220780	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000342a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000342a PTGER2	ChEMBL		None	None	None		O=C(c1ccc(F)cc1)N1CC(COc2ccc(Br)cc2)(C(=O)O)C1	10.6019/CHEMBL5210307
	10047541	139288	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	416	13	4	6	3.8	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccs1	10.1021/jm990542v
	CHEMBL369797	139288	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	416	13	4	6	3.8	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccs1	10.1021/jm990542v
	122180293	128421	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	4	0	5	4.9	COc1cc(-c2csc3ccccc23)cc2c1OCC(=O)N(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586357	128421	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	4	0	5	4.9	COc1cc(-c2csc3ccccc23)cc2c1OCC(=O)N(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	11955294	151546	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3909111	151546	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
	11955240	154768	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	352	8	3	3	3.5	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(CO)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3934202	154768	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	352	8	3	3	3.5	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(CO)cc2)[C@H](O)C[C@H]1Cl	nan
	44409910	147687	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(-c3ccccc3)c2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL382197	147687	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(-c3ccccc3)c2)s1	10.1016/j.bmcl.2006.01.018
	25195248	189714	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	540	6	1	4	4.6	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
	CHEMBL479263	189714	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	540	6	1	4	4.6	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
	118756024	128415	4	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	5	0	5	5.8	CCOc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586350	128415	4	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	5	0	5	5.8	CCOc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180286	128413	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586349	128413	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	10339756	149863	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	CHEMBL3895324	149863	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	122180264	128393	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	346	4	0	4	4.2	COc1cc(-c2ccccc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586327	128393	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	346	4	0	4	4.2	COc1cc(-c2ccccc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180267	128395	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586330	128395	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	11955255	153035	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3920560	153035	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	11495634	21677	13	None	-	4	Human	5.8	pIC50	=	5.8	Binding	Inhibition of EP2 receptorInhibition of EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2009.02.112
	CHEMBL1207972	21677	13	None	-	4	Human	5.8	pIC50	=	5.8	Binding	Inhibition of EP2 receptorInhibition of EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2009.02.112
	CHEMBL467114	21677	13	None	-	4	Human	5.8	pIC50	=	5.8	Binding	Inhibition of EP2 receptorInhibition of EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2009.02.112
	9820676	201824	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549461	201824	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	122180290	128418	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	370	3	0	3	5.9	c1cncc(CN2CCCc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586354	128418	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	370	3	0	3	5.9	c1cncc(CN2CCCc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	11575201	164201	0	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	C[C@H](NC(=O)c1cc(Cl)ccc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4078648	164201	0	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	C[C@H](NC(=O)c1cc(Cl)ccc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	72695027	113043	0	None	-28	2	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	CHEMBL3115074	113043	0	None	-28	2	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	CHEMBL3138992	113043	0	None	-28	2	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	122180256	128386	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	431	5	0	5	6.0	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586319	128386	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	431	5	0	5	6.0	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
	11955406	152882	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3919393	152882	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	44409738	146384	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL379746	146384	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmcl.2006.01.018
	11577792	166097	19	None	-1819	5	Human	5.7	pIC50	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4099851	166097	19	None	-1819	5	Human	5.7	pIC50	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	46879894	12953	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity to human EP2 receptor by radioligand displacement assayBinding affinity to human EP2 receptor by radioligand displacement assay	ChEMBL	565	6	1	5	7.2	Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(-c3cc(NS(=O)(=O)c4ccc(F)c(F)c4)no3)cc(F)cc12	10.1016/j.bmcl.2009.09.084
	CHEMBL1081186	12953	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity to human EP2 receptor by radioligand displacement assayBinding affinity to human EP2 receptor by radioligand displacement assay	ChEMBL	565	6	1	5	7.2	Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(-c3cc(NS(=O)(=O)c4ccc(F)c(F)c4)no3)cc(F)cc12	10.1016/j.bmcl.2009.09.084
	122180297	128425	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586362	128425	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	1883	9856	75	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	1916	9856	75	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	5280360	9856	75	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	913	9856	75	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	CHEMBL548	9856	75	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	DB00917	9856	75	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	1883	9856	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	1916	9856	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	5280360	9856	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	913	9856	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	CHEMBL548	9856	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	DB00917	9856	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	1883	9856	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	1916	9856	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	5280360	9856	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	913	9856	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	CHEMBL548	9856	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	DB00917	9856	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	122180249	128379	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586312	128379	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
	122180295	128422	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586359	128422	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	30956824	128378	4	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586311	128378	4	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
	122180250	128380	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586313	128380	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
	122180252	128382	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586315	128382	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
	122180288	128416	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586352	128416	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	9885481	202162	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	CHEMBL551951	202162	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	11955276	157530	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
	CHEMBL3956391	157530	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
	44570666	190049	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	522	6	1	4	4.5	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3ccc(F)c(F)c3)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
	CHEMBL479664	190049	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	522	6	1	4	4.5	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3ccc(F)c(F)c3)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
	58905388	165445	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	383	6	2	3	4.4	O=C(O)c1ccc(CNC(=O)c2cc(F)ccc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4092846	165445	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	383	6	2	3	4.4	O=C(O)c1ccc(CNC(=O)c2cc(F)ccc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
	10670992	66830	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	444	13	4	5	4.4	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(Cl)c1	10.1021/jm990542v
	CHEMBL173680	66830	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	444	13	4	5	4.4	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(Cl)c1	10.1021/jm990542v
	15486806	107263	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	392	13	4	4	3.5	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1	10.1021/jm990542v
	CHEMBL290969	107263	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	392	13	4	4	3.5	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1	10.1021/jm990542v
	45270403	201896	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	14	2	4	2.5	CC(C)CC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	CHEMBL550015	201896	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	14	2	4	2.5	CC(C)CC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	10180	10364	58	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
	49843471	10364	58	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
	CHEMBL2386081	10364	58	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
	DB12562	10364	58	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
	45271237	201878	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549870	201878	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	122180275	128402	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586338	128402	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	71733910	97110	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	436	3	1	3	4.9	O=C(O)Cn1c2c(c3cc(F)cc(Cl)c31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	CHEMBL2385900	97110	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	436	3	1	3	4.9	O=C(O)Cn1c2c(c3cc(F)cc(Cl)c31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	18376258	202681	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559065	202681	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	122180263	128392	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586326	128392	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	22246983	202641	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL558671	202641	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	1883	9856	75	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	1916	9856	75	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	5280360	9856	75	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	913	9856	75	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	CHEMBL548	9856	75	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	DB00917	9856	75	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	122180284	128411	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586347	128411	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180265	128394	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586328	128394	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180274	128401	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586337	128401	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180254	128384	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(Cl)cc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586317	128384	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(Cl)cc1)C2	10.1021/acs.jmedchem.5b00567
	122180255	128385	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	415	4	0	4	6.3	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C)cc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586318	128385	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	415	4	0	4	6.3	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C)cc1)C2	10.1021/acs.jmedchem.5b00567
	122180260	128390	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(Cl)c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586323	128390	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(Cl)c1)C2	10.1021/acs.jmedchem.5b00567
	45269575	203184	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	12	1	4	4.0	CCCCc1ccc(CN(CCCOc2cccc(C(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562825	203184	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	12	1	4	4.0	CCCCc1ccc(CN(CCCOc2cccc(C(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	45271234	201862	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	11	1	4	3.5	CCCCc1ccc(CN(Cc2ccccc2OCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549663	201862	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	11	1	4	3.5	CCCCc1ccc(CN(Cc2ccccc2OCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	45268716	202777	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	10	1	3	4.0	CCCCc1ccc(CN(c2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559955	202777	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	10	1	3	4.0	CCCCc1ccc(CN(c2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	16664733	161606	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of human recombinant EP2 receptor expressed in 293EBNA cellsInhibition of human recombinant EP2 receptor expressed in 293EBNA cells	ChEMBL	483	9	3	5	4.3	CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1	10.1016/j.bmcl.2006.12.025
	CHEMBL400404	161606	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of human recombinant EP2 receptor expressed in 293EBNA cellsInhibition of human recombinant EP2 receptor expressed in 293EBNA cells	ChEMBL	483	9	3	5	4.3	CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1	10.1016/j.bmcl.2006.12.025
	45266955	202424	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
	CHEMBL556416	202424	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
	44627515	203616	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	572	6	1	5	7.2	Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12	10.1021/jm9005912
	CHEMBL565799	203616	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	572	6	1	5	7.2	Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12	10.1021/jm9005912
	11618662	165601	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	421	6	2	5	4.6	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(C#N)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4094572	165601	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	421	6	2	5	4.6	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(C#N)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	11955257	160665	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3983069	160665	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	1883	9856	75	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	1916	9856	75	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	5280360	9856	75	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	913	9856	75	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	CHEMBL548	9856	75	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	DB00917	9856	75	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	1894	7744	41	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
	5311053	7744	41	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
	CHEMBL37853	7744	41	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
	DB11507	7744	41	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
	118175009	143463	0	None	-812	2	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
	CHEMBL3740325	143463	0	None	-812	2	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
	45271238	202420	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL556333	202420	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	1883	9856	75	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	1916	9856	75	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	5280360	9856	75	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	913	9856	75	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	CHEMBL548	9856	75	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	DB00917	9856	75	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	122180272	128399	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586335	128399	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180278	128405	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586341	128405	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180292	128420	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	3	0	4	5.4	CN1CCN(Cc2cccnc2)Cc2cc(-c3csc4ccccc34)ccc21	10.1021/acs.jmedchem.5b00567
	CHEMBL3586356	128420	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	3	0	4	5.4	CN1CCN(Cc2cccnc2)Cc2cc(-c3csc4ccccc34)ccc21	10.1021/acs.jmedchem.5b00567
	11296282	8191	32	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	590	6	1	5	7.3	Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C	10.1021/jm9005912
	5822	8191	32	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	590	6	1	5	7.3	Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C	10.1021/jm9005912
	CHEMBL565591	8191	32	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	590	6	1	5	7.3	Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C	10.1021/jm9005912
	44230999	174225	26	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4297666	174225	26	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	DB15071	174225	26	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	11955235	159530	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	9	3	3	4.2	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3973312	159530	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	9	3	3	4.2	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	44564571	193594	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL489310	193594	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
	11683088	165757	0	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(F)cc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4096216	165757	0	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(F)cc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	162671048	189586	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting methodDisplacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting method	ChEMBL	451	5	1	4	5.4	Cc1c(-c2cccs2)nc2ccc(Br)cc2c1C(=O)NCCc1cccnc1	10.1021/acs.jmedchem.0c00834
	CHEMBL4790821	189586	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting methodDisplacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting method	ChEMBL	451	5	1	4	5.4	Cc1c(-c2cccs2)nc2ccc(Br)cc2c1C(=O)NCCc1cccnc1	10.1021/acs.jmedchem.0c00834
	9934368	145699	11	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptorBinding affinity to rat EP2 receptor	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1021/jm9018756
	CHEMBL378376	145699	11	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptorBinding affinity to rat EP2 receptor	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1021/jm9018756
	9934368	145699	11	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL378376	145699	11	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1016/j.bmcl.2006.01.018
	44627395	203651	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	563	7	1	7	5.6	O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
	CHEMBL565992	203651	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	563	7	1	7	5.6	O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
	11955410	159308	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	9	2	4	4.3	COC(=O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(C)(C)CO)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3971493	159308	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	9	2	4	4.3	COC(=O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(C)(C)CO)cc2)[C@H](O)C[C@H]1Cl	nan
	5311239	137396	31	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	358	14	4	4	3.5	CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O	10.1021/jm990542v
	CHEMBL36817	137396	31	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	358	14	4	4	3.5	CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O	10.1021/jm990542v
	45268715	202755	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559760	202755	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	25114442	9835	56	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210307
	5817	9835	56	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210307
	CHEMBL3286797	9835	56	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210307
	DB12024	9835	56	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210307
	1883	9856	75	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	1916	9856	75	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	5280360	9856	75	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	913	9856	75	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	CHEMBL548	9856	75	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	DB00917	9856	75	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	1929	8386	55	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	9890801	8386	55	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	CHEMBL563646	8386	55	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	DB12022	8386	55	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	22246895	202343	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL554823	202343	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	18376196	201701	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL541516	201701	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
	58681352	161118	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
	CHEMBL3986829	161118	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
	122180281	128408	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cccc(Cl)c32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586344	128408	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cccc(Cl)c32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	16048029	202283	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	10	1	3	3.8	CC(C)(C)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL553468	202283	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	10	1	3	3.8	CC(C)(C)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	122180277	128404	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586340	128404	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180257	128387	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	459	5	0	6	5.8	COC(=O)c1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586320	128387	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	459	5	0	6	5.8	COC(=O)c1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
	122180258	128388	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C#N)cc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586321	128388	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C#N)cc1)C2	10.1021/acs.jmedchem.5b00567
	122180291	128419	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	371	3	1	4	5.4	c1cncc(CN2CCNc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586355	128419	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	371	3	1	4	5.4	c1cncc(CN2CCNc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	11955358	159861	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3976116	159861	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
	18376082	201702	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL541517	201702	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
	22246956	203098	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562291	203098	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	44409917	146028	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(F)c2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL378968	146028	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(F)c2)s1	10.1016/j.bmcl.2006.01.018
	122180273	128400	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586336	128400	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	11539410	97114	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	438	5	1	3	5.2	CCc1ccc(-c2ccc(C(=O)N3CCc4c(c5ccccc5n4CC(=O)O)C3)cc2)cc1	10.1021/jm400122f
	CHEMBL2385904	97114	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	438	5	1	3	5.2	CCc1ccc(-c2ccc(C(=O)N3CCc4c(c5ccccc5n4CC(=O)O)C3)cc2)cc1	10.1021/jm400122f
	45269576	202762	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559820	202762	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11653874	97134	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	384	3	1	3	4.1	O=C(O)Cn1c2c(c3ccccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	CHEMBL2386079	97134	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	384	3	1	3	4.1	O=C(O)Cn1c2c(c3ccccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	1955	6805	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	428	13	4	5	3.6	O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O	10.1021/jm990542v
	5311240	6805	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	428	13	4	5	3.6	O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O	10.1021/jm990542v
	CHEMBL36041	6805	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	428	13	4	5	3.6	O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O	10.1021/jm990542v
	44409733	147662	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	401	10	2	4	3.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL382029	147662	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	401	10	2	4	3.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2)s1	10.1016/j.bmcl.2006.01.018
	30897313	128376	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	128376	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	42484632	128377	5	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586310	128377	5	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
	122180270	128397	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586333	128397	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	22246893	202731	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559561	202731	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11524454	7733	55	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	Clc1ccc(c(c1)C(=O)N[C@H](c1ccc(cc1)C(=O)O)C)Oc1ccc(cc1)F	10.1016/j.bmcl.2017.01.067
	5857	7733	55	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	Clc1ccc(c(c1)C(=O)N[C@H](c1ccc(cc1)C(=O)O)C)Oc1ccc(cc1)F	10.1016/j.bmcl.2017.01.067
	CHEMBL591666	7733	55	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	Clc1ccc(c(c1)C(=O)N[C@H](c1ccc(cc1)C(=O)O)C)Oc1ccc(cc1)F	10.1016/j.bmcl.2017.01.067
	68505327	97135	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	418	3	1	3	4.7	O=C(O)Cn1c2c(c3cc(Cl)ccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	CHEMBL2386080	97135	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	418	3	1	3	4.7	O=C(O)Cn1c2c(c3cc(Cl)ccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	44564892	187301	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL475348	187301	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
	10126807	201877	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549869	201877	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	56927669	128423	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	128423	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	122180296	128424	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586361	128424	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	122180279	128406	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586342	128406	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180289	128417	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586353	128417	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180280	128407	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586343	128407	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	22246765	201977	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL550619	201977	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	44409918	172752	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccc(Cl)cc2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL425243	172752	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccc(Cl)cc2)s1	10.1016/j.bmcl.2006.01.018
	11955236	153234	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3922121	153234	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	122180283	128410	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586346	128410	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	45268713	202730	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	15	2	4	2.6	CCCCCC(O)CCCN(CCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	CHEMBL559560	202730	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	15	2	4	2.6	CCCCCC(O)CCCN(CCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	10223499	203120	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562411	203120	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	44564893	187302	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL475349	187302	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
	71733912	97113	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	430	5	1	3	4.5	O=C(O)Cn1c2c(c3cc(F)ccc31)CN(C(=O)CCc1cccc3ccccc13)CC2	10.1021/jm400122f
	CHEMBL2385903	97113	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	430	5	1	3	4.5	O=C(O)Cn1c2c(c3cc(F)ccc31)CN(C(=O)CCc1cccc3ccccc13)CC2	10.1021/jm400122f
	44564804	183479	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL459885	183479	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
	25114442	9835	56	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210121
	5817	9835	56	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210121
	CHEMBL3286797	9835	56	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210121
	DB12024	9835	56	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210121
	CHEMBL5281349	200889	0	None	-	1	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human recombinant PTGER2 assessed as dissociation constant by high throughput fluorescence polarization assayBinding affinity to human recombinant PTGER2 assessed as dissociation constant by high throughput fluorescence polarization assay	ChEMBL	1581	31	10	14	8.1	CC(C)C[C@H]1CN(CC(=O)NCCC(=O)N[C@@H](CCCCNC(=S)Nc2ccccc2)C(N)=O)C(=O)CCSCc2ccc(cc2)C(=O)N[C@@H](CC(C)C)CN(C(=O)CC2CC2)CC(=O)N[C@@H](CCCCN)CN(C(=O)CCc2ccccc2)CC(=O)N[C@@H](Cc2ccccc2)CN(C(=O)CCC2CCCCC2)CC(=O)N1	10.1016/j.bmcl.2023.129255
	CHEMBL5279002	200788	0	None	-	1	Human	7.8	pKd	=	7.8	Binding	Binding affinity to human recombinant PTGER2 assessed as dissociation constant by high throughput fluorescence polarization assayBinding affinity to human recombinant PTGER2 assessed as dissociation constant by high throughput fluorescence polarization assay	ChEMBL	1921	33	12	18	12.0	CC(C)C[C@H]1CN(CC(=O)NCCC(=O)N[C@@H](CCCCNC(=S)Nc2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)C(N)=O)C(=O)CCSCc2ccc(cc2)C(=O)N[C@@H](CCCCN)CN(C(=O)CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)CN(C(=O)CCC2CCCCC2)CC(=O)N[C@@H](Cc2ccccc2)CN(C(=O)Cc2ccc3ccccc3c2)CC(=O)N1	10.1016/j.bmcl.2023.129255
	46213069	9837	0	None	1905	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to EP2 receptor in human mast cell assessed as inhibition constantBinding affinity to EP2 receptor in human mast cell assessed as inhibition constant	ChEMBL	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	10.1021/acs.jmedchem.1c00816
	8538	9837	0	None	1905	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to EP2 receptor in human mast cell assessed as inhibition constantBinding affinity to EP2 receptor in human mast cell assessed as inhibition constant	ChEMBL	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	10.1021/acs.jmedchem.1c00816
	CHEMBL5285583	9837	0	None	1905	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to EP2 receptor in human mast cell assessed as inhibition constantBinding affinity to EP2 receptor in human mast cell assessed as inhibition constant	ChEMBL	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	10.1021/acs.jmedchem.1c00816
	9807448	209951	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Compound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorCompound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64246	209951	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Compound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorCompound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	1883	9856	75	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	1916	9856	75	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	5280360	9856	75	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	913	9856	75	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL548	9856	75	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	DB00917	9856	75	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	51039069	135981	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(F)cc2)cc1	nan
	CHEMBL3670659	135981	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(F)cc2)cc1	nan
	51039071	135985	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccccc3)cc2-c2ccc(F)cc2)o1	nan
	CHEMBL3670663	135985	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccccc3)cc2-c2ccc(F)cc2)o1	nan
	10481859	81942	0	None	-4	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
	CHEMBL2036321	81942	0	None	-4	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
	1932	9716	5	None	1	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	5311228	9716	5	None	1	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	CHEMBL3286796	9716	5	None	1	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	1883	9856	75	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	1916	9856	75	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	5280360	9856	75	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	913	9856	75	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	CHEMBL548	9856	75	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	DB00917	9856	75	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	57384034	78082	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957436	78082	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
	57384034	78082	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957436	78082	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
	67078793	135975	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	287	3	2	2	4.2	O=C(O)c1[nH]c(-c2cccs2)cc1-c1ccc(F)cc1	nan
	CHEMBL3670653	135975	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	287	3	2	2	4.2	O=C(O)c1[nH]c(-c2cccs2)cc1-c1ccc(F)cc1	nan
	18376177	10525	50	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	5816	10525	50	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	CHEMBL2107783	10525	50	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	DB12623	10525	50	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	11855865	160056	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	160056	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	10116114	132664	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL364841	132664	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	13231966	107728	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL294108	107728	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	13231966	107728	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL294108	107728	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
	44455046	102502	0	None	-50118	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL258332	102502	0	None	-50118	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
	44304057	210038	0	None	-288	4	Mouse	6.0	pKi	=	6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.6	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL64598	210038	0	None	-288	4	Mouse	6.0	pKi	=	6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.6	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	10181606	213130	0	None	-645	7	Human	5.0	pKi	=	5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
	CHEMBL87371	213130	0	None	-645	7	Human	5.0	pKi	=	5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
	118517483	151049	0	None	-93	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	CHEMBL3904946	151049	0	None	-93	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	71455094	88656	0	None	-407	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	623	12	1	8	6.4	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
	CHEMBL2164609	88656	0	None	-407	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	623	12	1	8	6.4	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
	44303627	209984	0	None	467	2	Mouse	8.0	pKi	=	8.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64358	209984	0	None	467	2	Mouse	8.0	pKi	=	8.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	5311035	104579	29	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.09.074
	CHEMBL271896	104579	29	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.09.074
	52941778	23314	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	712	14	2	4	11.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1Oc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1Oc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237304	23314	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	712	14	2	4	11.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1Oc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1Oc1ccccc1	10.1016/j.bmcl.2004.11.051
	5311035	104579	29	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.11.020
	CHEMBL271896	104579	29	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.11.020
	44390782	71377	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	10	1	3	5.5	COc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL181691	71377	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	10	1	3	5.5	COc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	44303907	209520	0	None	-	1	Mouse	6.0	pKi	=	6.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	390	10	3	4	3.5	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CC#CCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL61925	209520	0	None	-	1	Mouse	6.0	pKi	=	6.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	390	10	3	4	3.5	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CC#CCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	10431288	76141	0	None	-1318	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	403	12	2	3	4.5	CCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929546	76141	0	None	-1318	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	403	12	2	3	4.5	CCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	46201043	207361	0	None	-5011	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	CHEMBL599154	207361	0	None	-5011	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	9939791	168697	0	None	-912	8	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
	CHEMBL415310	168697	0	None	-912	8	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
	9873528	213709	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	7	1	5	6.9	O=C(NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)OCc1ccccc1	10.1016/s0960-894x(99)00465-5
	CHEMBL91063	213709	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	7	1	5	6.9	O=C(NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)OCc1ccccc1	10.1016/s0960-894x(99)00465-5
	134155748	157948	0	None	25	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959653	157948	0	None	25	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	11502897	149571	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	149571	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11502897	149571	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	149571	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	119461	7108	72	None	-3	10	Human	5.9	pKi	=	5.9	Binding	Inhibition of EP2 receptor (unknown origin) by competitive binding assayInhibition of EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	1896	7108	72	None	-3	10	Human	5.9	pKi	=	5.9	Binding	Inhibition of EP2 receptor (unknown origin) by competitive binding assayInhibition of EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	CHEMBL1317823	7108	72	None	-3	10	Human	5.9	pKi	=	5.9	Binding	Inhibition of EP2 receptor (unknown origin) by competitive binding assayInhibition of EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	118517359	151174	0	None	-114	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	151174	0	None	-114	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	24952927	208010	0	None	-851	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(C(F)(F)F)cc1	10.1021/jm901771h
	CHEMBL603690	208010	0	None	-851	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(C(F)(F)F)cc1	10.1021/jm901771h
	44304404	107357	0	None	-23	4	Mouse	7.9	pKi	=	7.9	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	12	3	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	CHEMBL291630	107357	0	None	-23	4	Mouse	7.9	pKi	=	7.9	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	12	3	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	10291963	91483	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL222715	91483	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	44520989	206543	0	None	-2	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	396	6	2	4	5.0	Cc1c(C)c2c(c(C)c1O)CCC(C)(CCOc1ccccc1/C=C/C(=O)O)O2	10.1016/j.bmc.2009.08.007
	CHEMBL593764	206543	0	None	-2	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	396	6	2	4	5.0	Cc1c(C)c2c(c(C)c1O)CCC(C)(CCOc1ccccc1/C=C/C(=O)O)O2	10.1016/j.bmc.2009.08.007
	23016719	207999	0	None	-1	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(OCc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL603625	207999	0	None	-1	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(OCc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	44304055	109500	0	None	-371	4	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCSCCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL304887	109500	0	None	-371	4	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCSCCC(=O)O	10.1016/s0960-894x(01)00364-x
	44304034	207373	0	None	-165	3	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
	CHEMBL59921	207373	0	None	-165	3	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
	9817405	172182	5	None	-165	6	Human	4.9	pKi	=	4.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/j.bmcl.2006.08.025
	CHEMBL423815	172182	5	None	-165	6	Human	4.9	pKi	=	4.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/j.bmcl.2006.08.025
	72695027	113043	0	None	-28	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	CHEMBL3115074	113043	0	None	-28	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	CHEMBL3138992	113043	0	None	-28	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	72706947	181443	20	None	-5128	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	363	11	2	3	3.4	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL4558749	181443	20	None	-5128	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	363	11	2	3	3.4	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	118517488	160490	0	None	-56	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	CHEMBL3981554	160490	0	None	-56	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	44442327	101234	0	None	-147	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251294	101234	0	None	-147	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	17757350	159533	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	CHEMBL3973347	159533	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	10112412	76243	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933719	76243	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
	10112412	76243	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933719	76243	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	118517489	150469	0	None	-44	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	CHEMBL3900245	150469	0	None	-44	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	51039070	135982	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	433	6	5	5	4.2	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(O)cc2)cc1	nan
	CHEMBL3670660	135982	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	433	6	5	5	4.2	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(O)cc2)cc1	nan
	44303626	174961	0	None	-	1	Mouse	7.9	pKi	=	7.9	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL433249	174961	0	None	-	1	Mouse	7.9	pKi	=	7.9	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	57400249	76252	0	None	3	3	Mouse	7.9	pKi	=	7.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	410	9	2	6	3.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CC2CCCC2)n1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933728	76252	0	None	3	3	Mouse	7.9	pKi	=	7.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	410	9	2	6	3.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CC2CCCC2)n1	10.1016/j.bmcl.2011.10.109
	10291963	91483	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
	CHEMBL222715	91483	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
	11315933	130072	4	None	-707	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	413	7	1	4	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL361457	130072	4	None	-707	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	413	7	1	4	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	44394432	134104	0	None	-10	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL365908	134104	0	None	-10	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	23017109	206853	0	None	-6	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	416	10	1	5	4.3	O=C(O)COCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL595830	206853	0	None	-6	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	416	10	1	5	4.3	O=C(O)COCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	15907747	213802	0	None	-257	4	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
	CHEMBL91537	213802	0	None	-257	4	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
	118517361	160149	0	None	-218	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	CHEMBL3978590	160149	0	None	-218	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	9975502	101264	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251504	101264	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	3356	9060	73	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
	4326	9060	73	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
	9867642	9060	73	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
	CHEMBL426559	9060	73	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
	DB11629	9060	73	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
	70667255	158253	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3962183	158253	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	24760052	157964	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3959769	157964	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	44304436	210099	0	None	-35	5	Mouse	7.9	pKi	=	7.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	400	14	3	5	3.8	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL64854	210099	0	None	-35	5	Mouse	7.9	pKi	=	7.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	400	14	3	5	3.8	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
	44320373	213029	0	None	5	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	376	9	1	2	5.8	O=C(O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1	10.1016/s0960-894x(02)00518-8
	CHEMBL86799	213029	0	None	5	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	376	9	1	2	5.8	O=C(O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1	10.1016/s0960-894x(02)00518-8
	52947851	23317	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237315	23317	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2004.11.051
	52947851	23317	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL1237315	23317	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
	9813912	144660	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	264	5	1	1	4.0	O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL376282	144660	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	264	5	1	1	4.0	O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
	57394140	76146	0	None	-707	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	419	13	2	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929550	76146	0	None	-707	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	419	13	2	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	134146425	155982	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3943966	155982	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	11519006	109263	0	None	-229	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]PGE-2 binding to Prostanoid EP2 receptorInhibition of [3H]PGE-2 binding to Prostanoid EP2 receptor	ChEMBL	481	8	1	5	6.1	O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1	10.1016/j.bmcl.2005.04.076
	CHEMBL2373410	109263	0	None	-229	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]PGE-2 binding to Prostanoid EP2 receptorInhibition of [3H]PGE-2 binding to Prostanoid EP2 receptor	ChEMBL	481	8	1	5	6.1	O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1	10.1016/j.bmcl.2005.04.076
	CHEMBL3040272	109263	0	None	-229	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]PGE-2 binding to Prostanoid EP2 receptorInhibition of [3H]PGE-2 binding to Prostanoid EP2 receptor	ChEMBL	481	8	1	5	6.1	O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1	10.1016/j.bmcl.2005.04.076
	9808508	118337	0	None	-245	3	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	586	7	1	4	6.3	O=C(Cc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	CHEMBL328067	118337	0	None	-245	3	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	586	7	1	4	6.3	O=C(Cc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	44455115	102337	0	None	-15	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL257658	102337	0	None	-15	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	118517359	151174	0	None	-114	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	151174	0	None	-114	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	44289922	170303	0	None	-954	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL42027	170303	0	None	-954	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	11855868	159323	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	159323	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	57393340	76250	0	None	-10	4	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	530	12	2	7	4.2	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(COCC(F)(F)F)c2)n1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933726	76250	0	None	-10	4	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	530	12	2	7	4.2	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(COCC(F)(F)F)c2)n1	10.1016/j.bmcl.2011.10.109
	11855868	159323	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	159323	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	57894053	81945	0	None	-79	3	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036324	81945	0	None	-79	3	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	155516303	176856	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2cccc3oc(C(=O)O)cc23)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4443289	176856	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2cccc3oc(C(=O)O)cc23)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	18973764	23419	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	346	8	1	2	5.1	O=C(O)c1ccc(CCCc2ccccc2OCc2ccccc2)cc1	10.1016/s0960-894x(03)00794-7
	CHEMBL124199	23419	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	346	8	1	2	5.1	O=C(O)c1ccc(CCCc2ccccc2OCc2ccccc2)cc1	10.1016/s0960-894x(03)00794-7
	44304058	209956	0	None	-66	5	Mouse	6.8	pKi	=	6.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	374	13	3	6	2.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL64254	209956	0	None	-66	5	Mouse	6.8	pKi	=	6.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	374	13	3	6	2.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O	10.1016/s0960-894x(01)00364-x
	23017216	205938	0	None	-1380	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	439	9	2	3	5.4	O=C(O)CCc1ccc(COc2ccccc2)cc1C(=O)NCc1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	CHEMBL589411	205938	0	None	-1380	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	439	9	2	3	5.4	O=C(O)CCc1ccc(COc2ccccc2)cc1C(=O)NCc1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	44304051	109537	0	None	-213	4	Mouse	5.8	pKi	=	5.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
	CHEMBL305126	109537	0	None	-213	4	Mouse	5.8	pKi	=	5.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
	134143292	152006	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3912658	152006	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465595	152201	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
	CHEMBL3914108	152201	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
	59465574	152723	0	None	1	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
	CHEMBL3918084	152723	0	None	1	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
	118517490	159934	0	None	-125	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	CHEMBL3976710	159934	0	None	-125	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	72695027	113043	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1021/ml5000367
	CHEMBL3115074	113043	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1021/ml5000367
	CHEMBL3138992	113043	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1021/ml5000367
	72695027	113043	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	nan
	CHEMBL3115074	113043	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	nan
	CHEMBL3138992	113043	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	nan
	24952577	207340	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	399	6	2	3	5.2	C[C@H](NC(=O)c1cscc1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	CHEMBL599051	207340	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	399	6	2	3	5.2	C[C@H](NC(=O)c1cscc1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	1929	8386	55	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	9890801	8386	55	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	CHEMBL563646	8386	55	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	DB12022	8386	55	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	44349503	175169	0	None	-100	4	Human	5.8	pKi	=	5.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	553	10	1	5	7.1	O=C(CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
	CHEMBL434637	175169	0	None	-100	4	Human	5.8	pKi	=	5.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	553	10	1	5	7.1	O=C(CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
	44419351	90918	0	None	-28	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	533	12	1	5	6.2	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL220821	90918	0	None	-28	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	533	12	1	5	6.2	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	44324368	103293	0	None	-3	4	Human	4.8	pKi	=	4.8	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	587	6	2	4	6.8	O=C(Nc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	CHEMBL262690	103293	0	None	-3	4	Human	4.8	pKi	=	4.8	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	587	6	2	4	6.8	O=C(Nc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	10144273	212613	0	None	-131	4	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	558	8	1	5	7.2	O=C(CCc1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL83450	212613	0	None	-131	4	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	558	8	1	5	7.2	O=C(CCc1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	11855871	153186	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	153186	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855871	153186	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	153186	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855866	151380	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	151380	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855866	151380	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	151380	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	53494965	71587	0	None	-5	3	Mouse	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C	10.1016/j.bmc.2011.08.007
	CHEMBL1819611	71587	0	None	-5	3	Mouse	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C	10.1016/j.bmc.2011.08.007
	52947847	23310	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1.Cc1cccc(C/C=C\c2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237300	23310	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1.Cc1cccc(C/C=C\c2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	11314979	72883	0	None	-11	4	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	379	7	1	4	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(C)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL183933	72883	0	None	-11	4	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	379	7	1	4	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(C)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	11234840	131833	0	None	-4	2	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1cccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)c1	10.1016/j.bmcl.2004.06.006
	CHEMBL364421	131833	0	None	-4	2	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1cccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)c1	10.1016/j.bmcl.2004.06.006
	56949973	76147	0	None	-3388	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	407	11	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929551	76147	0	None	-3388	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	407	11	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	57894092	81933	0	None	-8511	3	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	12	2	6	4.5	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036312	81933	0	None	-8511	3	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	12	2	6	4.5	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
	10157810	70561	0	None	3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	400	9	1	3	5.6	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1021/ml300191g
	CHEMBL180191	70561	0	None	3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	400	9	1	3	5.6	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1021/ml300191g
	44442334	101303	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	327	7	1	2	3.8	CC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251710	101303	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	327	7	1	2	3.8	CC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	11495634	21677	13	None	-218	4	Mouse	5.8	pKi	=	5.8	Binding	Antagonist activity at mouse EP2 receptorAntagonist activity at mouse EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2012.11.046
	CHEMBL1207972	21677	13	None	-218	4	Mouse	5.8	pKi	=	5.8	Binding	Antagonist activity at mouse EP2 receptorAntagonist activity at mouse EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2012.11.046
	CHEMBL467114	21677	13	None	-218	4	Mouse	5.8	pKi	=	5.8	Binding	Antagonist activity at mouse EP2 receptorAntagonist activity at mouse EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2012.11.046
	92135977	159675	0	None	-275	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	CHEMBL3974652	159675	0	None	-275	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	52945421	23308	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(OCc2ccccc2)c1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(OCc2ccccc2)c1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237298	23308	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(OCc2ccccc2)c1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(OCc2ccccc2)c1	10.1016/j.bmcl.2004.11.051
	21362912	177954	0	None	-8	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	5	6.7	O=C(CCCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL445895	177954	0	None	-8	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	5	6.7	O=C(CCCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	23017362	206757	0	None	-45	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	10	1	4	5.1	O=C(O)CCCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL595157	206757	0	None	-45	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	10	1	4	5.1	O=C(O)CCCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	11577792	166097	19	None	-1819	5	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4099851	166097	19	None	-1819	5	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	10448293	161200	0	None	-41	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	313	6	1	2	3.4	CC(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL398947	161200	0	None	-41	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	313	6	1	2	3.4	CC(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	11855324	149383	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	149383	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	57395059	76249	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933725	76249	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmcl.2011.10.109
	57395059	76249	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1933725	76249	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmc.2012.02.018
	11855865	160056	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	160056	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	57403612	78080	0	None	-239	3	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	433	9	2	4	4.2	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmc.2012.02.018
	CHEMBL1957434	78080	0	None	-239	3	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	433	9	2	4	4.2	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmc.2012.02.018
	15948325	9304	45	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	603	11	1	8	4.7	CCOc1c2CN(C(=O)c2c(c2c1nccc2)OCC)c1ccc(cc1C)CS(=O)(=O)NC(=O)Cc1ccccc1OC	10.1016/j.bmcl.2008.01.103
	5856	9304	45	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	603	11	1	8	4.7	CCOc1c2CN(C(=O)c2c(c2c1nccc2)OCC)c1ccc(cc1C)CS(=O)(=O)NC(=O)Cc1ccccc1OC	10.1016/j.bmcl.2008.01.103
	CHEMBL402162	9304	45	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	603	11	1	8	4.7	CCOc1c2CN(C(=O)c2c(c2c1nccc2)OCC)c1ccc(cc1C)CS(=O)(=O)NC(=O)Cc1ccccc1OC	10.1016/j.bmcl.2008.01.103
	59465577	149967	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3896183	149967	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	57893982	81939	0	None	-4	3	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	CHEMBL2036318	81939	0	None	-4	3	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	57464006	81943	0	None	-17	4	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036322	81943	0	None	-17	4	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	9807448	209951	0	None	-1	4	Mouse	8.7	pKi	=	8.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64246	209951	0	None	-1	4	Mouse	8.7	pKi	=	8.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	67078538	135976	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	269	3	3	3	3.3	O=C(O)c1[nH]c(-c2ccoc2)cc1-c1ccc(O)cc1	nan
	CHEMBL3670654	135976	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	269	3	3	3	3.3	O=C(O)c1[nH]c(-c2ccoc2)cc1-c1ccc(O)cc1	nan
	44303952	107663	0	None	41	4	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL293697	107663	0	None	41	4	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	10361472	71982	0	None	-199	3	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)cc3c(CC(=O)O)cccc32)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL182555	71982	0	None	-199	3	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)cc3c(CC(=O)O)cccc32)cc1	10.1016/j.bmcl.2004.07.039
	10118889	213052	0	None	-74	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1cccc(CSCCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL86933	213052	0	None	-74	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1cccc(CSCCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	11187675	71988	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL182572	71988	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
	12002527	81935	0	None	-19952	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	493	12	2	5	5.1	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2cc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036314	81935	0	None	-19952	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	493	12	2	5	5.1	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2cc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
	24953628	207382	0	None	-63	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(Cl)cc1	10.1021/jm901771h
	CHEMBL599262	207382	0	None	-63	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(Cl)cc1	10.1021/jm901771h
	57529188	153973	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	153973	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	57529188	153973	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	153973	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	44444721	161185	0	None	-77	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL398827	161185	0	None	-77	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
	44455084	104643	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
	CHEMBL272277	104643	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
	58932681	81947	0	None	-100	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036326	81947	0	None	-100	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
	10116116	71185	0	None	-26	5	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL1813115	71185	0	None	-26	5	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	10206535	73346	0	None	-398	4	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	488	6	1	6	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccc(F)cc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL185251	73346	0	None	-398	4	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	488	6	1	6	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccc(F)cc3O2)cc1	10.1016/j.bmcl.2004.07.039
	44320126	213191	0	None	-17	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	537	11	1	7	6.2	Cc1cccc(OCCCOc2ccc(-c3ccccc3COC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL87816	213191	0	None	-17	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	537	11	1	7	6.2	Cc1cccc(OCCCOc2ccc(-c3ccccc3COC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	22009011	70847	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(/C=C/C(O)c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	CHEMBL180742	70847	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(/C=C/C(O)c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	11187675	71988	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL182572	71988	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
	44419380	89854	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL218178	89854	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	44419384	89855	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL218179	89855	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	57894081	81929	0	None	-3467	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	503	12	2	4	5.6	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036308	81929	0	None	-3467	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	503	12	2	4	5.6	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2012.04.008
	23017746	206628	0	None	-13	3	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	8	1	3	6.2	O=C(O)/C=C/c1ccc(Cc2cccs2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL594365	206628	0	None	-13	3	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	8	1	3	6.2	O=C(O)/C=C/c1ccc(Cc2cccs2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	9846782	107682	7	None	-676	3	Mouse	5.7	pKi	=	5.7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	454	13	3	7	2.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	CHEMBL293856	107682	7	None	-676	3	Mouse	5.7	pKi	=	5.7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	454	13	3	7	2.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	15907748	118241	0	None	-147	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	615	7	2	4	7.0	C[C@H](NC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
	CHEMBL327597	118241	0	None	-147	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	615	7	2	4	7.0	C[C@H](NC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
	138	9855	88	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	149351	9855	88	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	1882	9855	88	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	5280723	9855	88	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL495	9855	88	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	DB00770	9855	88	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	1883	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	1916	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	5280360	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	913	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	CHEMBL548	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	DB00917	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	1883	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	1916	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	5280360	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	913	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	CHEMBL548	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	DB00917	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	57396660	78083	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957437	78083	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.02.018
	57396660	78083	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957437	78083	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.04.008
	10348321	81946	0	None	-87	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	585	10	2	8	6.0	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036325	81946	0	None	-87	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	585	10	2	8	6.0	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	58932678	82063	0	None	-104	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
	CHEMBL2037290	82063	0	None	-104	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
	56672020	71599	0	None	-1	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	7	2	5	4.6	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3F)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819623	71599	0	None	-1	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	7	2	5	4.6	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3F)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	11337782	91718	0	None	-12	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	373	10	2	3	3.6	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2CC[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
	CHEMBL223744	91718	0	None	-12	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	373	10	2	3	3.6	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2CC[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
	9863804	100873	0	None	-8	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249136	100873	0	None	-8	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	9938669	174837	0	None	-154	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	8	1	5	6.2	O=C(COc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	CHEMBL432380	174837	0	None	-154	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	8	1	5	6.2	O=C(COc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	10113454	184280	0	None	-1380	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	429	12	2	3	4.4	O=C(O)CCCCCCN1C(=O)CC[C@@H]1CC[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL46395	184280	0	None	-1380	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	429	12	2	3	4.4	O=C(O)CCCCCCN1C(=O)CC[C@@H]1CC[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	118517483	151049	0	None	-93	2	Human	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	CHEMBL3904946	151049	0	None	-93	2	Human	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	11488860	26063	0	None	-5370	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to prostanoid receptor EP2 receptorBinding affinity to prostanoid receptor EP2 receptor	ChEMBL	497	5	1	4	5.7	C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	10.1016/j.bmcl.2010.10.018
	CHEMBL1290413	26063	0	None	-5370	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to prostanoid receptor EP2 receptorBinding affinity to prostanoid receptor EP2 receptor	ChEMBL	497	5	1	4	5.7	C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	10.1016/j.bmcl.2010.10.018
	24760055	150666	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	CHEMBL3901873	150666	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	24760055	150666	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	CHEMBL3901873	150666	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	11855591	151214	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	151214	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	11855591	151214	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	151214	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	10414412	81941	0	None	-6	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)c(C)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036320	81941	0	None	-6	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)c(C)c1	10.1016/j.bmc.2012.04.008
	11408533	148105	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
	CHEMBL383484	148105	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
	11408533	148105	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	CHEMBL383484	148105	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	11743212	23936	0	None	-758	7	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	426	7	1	3	6.8	O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL125588	23936	0	None	-758	7	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	426	7	1	3	6.8	O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	56658143	71579	0	None	-16	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	468	8	2	6	3.4	CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819604	71579	0	None	-16	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	468	8	2	6	3.4	CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	9809136	113666	0	None	-2290	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	614	7	1	4	7.1	CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
	CHEMBL314533	113666	0	None	-2290	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	614	7	1	4	7.1	CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
	9874010	213969	0	None	-1348	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	629	8	1	4	6.9	CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	CHEMBL92539	213969	0	None	-1348	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	629	8	1	4	6.9	CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	10229201	162355	0	None	-87	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL404414	162355	0	None	-87	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
	10076580	82064	0	None	-158	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	563	10	2	8	5.5	Cc1cc(C)c2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
	CHEMBL2037291	82064	0	None	-158	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	563	10	2	8	5.5	Cc1cc(C)c2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
	132836	66469	23	None	1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	10.1021/jm401431x
	CHEMBL1722929	66469	23	None	1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	10.1021/jm401431x
	57403799	76244	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933720	76244	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmcl.2011.10.109
	57403799	76244	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933720	76244	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmc.2012.02.018
	5311035	104579	29	None	-4	9	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
	CHEMBL271896	104579	29	None	-4	9	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
	44303980	174853	0	None	-	1	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL432522	174853	0	None	-	1	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
	22009004	148529	0	None	-2884	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1021/ml300191g
	CHEMBL385955	148529	0	None	-2884	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1021/ml300191g
	10270893	101003	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249954	101003	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	44303889	209996	0	None	-	1	Mouse	7.6	pKi	=	7.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64423	209996	0	None	-	1	Mouse	7.6	pKi	=	7.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
	17751059	155047	0	None	56	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3936540	155047	0	None	56	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	21974328	73044	0	None	-26	5	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	443	6	1	6	4.4	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Oc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL184684	73044	0	None	-26	5	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	443	6	1	6	4.4	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Oc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	10228100	71188	0	None	-43	5	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	488	6	1	6	4.7	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL1813118	71188	0	None	-43	5	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	488	6	1	6	4.7	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	44349551	23586	0	None	-47	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	415	8	2	4	6.2	O=C(O)CNc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL124675	23586	0	None	-47	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	415	8	2	4	6.2	O=C(O)CNc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	10158725	23600	0	None	-109	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL124738	23600	0	None	-109	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	44320405	112942	0	None	-5	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.2	O=C(NS(=O)(=O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL313700	112942	0	None	-5	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.2	O=C(NS(=O)(=O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)c1cccs1	10.1016/s0960-894x(02)00518-8
	52944194	23315	0	None	-194	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	936	18	4	6	12.8	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(CO)c1OCc1c(Cl)cccc1Cl.O=C(O)/C=C/c1ccccc1C/C=C/c1cccc(CO)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	CHEMBL1237305	23315	0	None	-194	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	936	18	4	6	12.8	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(CO)c1OCc1c(Cl)cccc1Cl.O=C(O)/C=C/c1ccccc1C/C=C/c1cccc(CO)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	52947852	23318	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237316	23318	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2004.11.051
	52947852	23318	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
	CHEMBL1237316	23318	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
	44419388	90190	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	294	6	1	2	4.0	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
	CHEMBL219590	90190	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	294	6	1	2	4.0	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
	11339240	91503	0	None	-3548	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	423	10	2	4	3.2	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
	CHEMBL222834	91503	0	None	-3548	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	423	10	2	4	3.2	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
	9885106	91548	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmcl.2011.10.109
	CHEMBL223151	91548	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmcl.2011.10.109
	9885106	91548	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmc.2012.02.018
	CHEMBL223151	91548	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmc.2012.02.018
	44304258	109133	0	None	-114	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL303787	109133	0	None	-114	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	44455158	104497	0	None	-933	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	331	8	2	3	2.6	CCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL271488	104497	0	None	-933	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	331	8	2	3	2.6	CCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	9821171	104642	0	None	-51286	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL272276	104642	0	None	-51286	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
	44304011	209587	0	None	-83	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL62305	209587	0	None	-83	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	44290263	108106	0	None	-3235	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	453	12	3	4	5.2	Cc1cc(O)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCCCCCC(=O)O)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL296715	108106	0	None	-3235	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	453	12	3	4	5.2	Cc1cc(O)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCCCCCC(=O)O)c1	10.1016/j.bmcl.2004.01.063
	77050677	135362	0	None	-588	2	Human	6.6	pKi	=	6.6	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	385	10	2	4	3.7	CC(C)[C@@H](OCCOc1ccccc1)C(=O)N[C@@H](C)c1ccc(C(=O)O)cc1	nan
	CHEMBL3667607	135362	0	None	-588	2	Human	6.6	pKi	=	6.6	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	385	10	2	4	3.7	CC(C)[C@@H](OCCOc1ccccc1)C(=O)N[C@@H](C)c1ccc(C(=O)O)cc1	nan
	11855325	151469	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	151469	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	21362900	212619	0	None	-58	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL83518	212619	0	None	-58	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	11418818	73436	0	None	-14	4	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	423	10	1	5	5.2	CCCCOc1ccc(C(=O)n2c(C)c(CCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL185369	73436	0	None	-14	4	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	423	10	1	5	5.2	CCCCOc1ccc(C(=O)n2c(C)c(CCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	53358921	71215	0	None	-562	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	482	7	1	5	5.4	CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1	10.1016/j.bmc.2011.06.014
	CHEMBL1813287	71215	0	None	-562	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	482	7	1	5	5.4	CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1	10.1016/j.bmc.2011.06.014
	10181606	213130	0	None	-645	7	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL87371	213130	0	None	-645	7	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	118517360	150753	0	None	-1380	2	Human	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
	CHEMBL3902700	150753	0	None	-1380	2	Human	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
	44444714	100913	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249341	100913	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	57893848	81944	0	None	-234	2	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036323	81944	0	None	-234	2	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	21974362	128822	0	None	-1	4	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2COc3ccccc3C2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL359564	128822	0	None	-1	4	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2COc3ccccc3C2)cc1	10.1016/j.bmcl.2004.07.039
	9886718	209942	0	None	-398	4	Mouse	6.6	pKi	=	6.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL64217	209942	0	None	-398	4	Mouse	6.6	pKi	=	6.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	118175009	143463	0	None	-812	2	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
	CHEMBL3740325	143463	0	None	-812	2	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
	10157813	208395	0	None	-177	4	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	400	9	1	4	4.7	O=C(O)CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL605833	208395	0	None	-177	4	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	400	9	1	4	4.7	O=C(O)CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	59465587	151968	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
	CHEMBL3912391	151968	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
	10205205	100943	0	None	-47	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	466	10	2	5	3.3	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(OC(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249539	100943	0	None	-47	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	466	10	2	5	3.3	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(OC(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
	10089562	161201	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL398948	161201	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	44304335	209757	0	None	-37	4	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	10	4	4	4.0	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
	CHEMBL63061	209757	0	None	-37	4	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	10	4	4	4.0	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
	21362879	23340	0	None	-107	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1cc(-c2ccccc2OCc2ccccc2)cs1	10.1016/s0960-894x(03)00794-7
	CHEMBL123855	23340	0	None	-107	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1cc(-c2ccccc2OCc2ccccc2)cs1	10.1016/s0960-894x(03)00794-7
	21362853	25304	0	None	-32	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2COc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL127482	25304	0	None	-32	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2COc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	12112239	113337	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	549	12	1	6	6.3	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL314200	113337	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	549	12	1	6	6.3	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	21362893	213106	0	None	-54	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	6	6.0	Cc1cccc(OCCCOc2ccc(-c3ccccc3CCC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL87263	213106	0	None	-54	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	6	6.0	Cc1cccc(OCCCOc2ccc(-c3ccccc3CCC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	44320321	213213	0	None	-6	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	563	12	1	6	6.6	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL87975	213213	0	None	-6	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	563	12	1	6	6.6	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	52941777	23312	0	None	1	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	744	16	2	4	10.9	Cc1cccc(/C=C/Cc2ccccc2CC(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2CC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237302	23312	0	None	1	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	744	16	2	4	10.9	Cc1cccc(/C=C/Cc2ccccc2CC(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2CC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	44393681	73635	0	None	-1	3	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	5.2	CCCCOc1ccc(C(=O)n2c(CCC)c(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL186244	73635	0	None	-1	3	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	5.2	CCCCOc1ccc(C(=O)n2c(CCC)c(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	10202765	179466	0	None	-18197	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	427	11	2	3	4.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL45008	179466	0	None	-18197	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	427	11	2	3	4.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	71458758	127640	0	None	-21	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	615	14	1	4	7.8	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C	10.1021/ml300191g
	CHEMBL2164612	127640	0	None	-21	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	615	14	1	4	7.8	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C	10.1021/ml300191g
	CHEMBL3558858	127640	0	None	-21	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	615	14	1	4	7.8	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C	10.1021/ml300191g
	57396825	76248	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933724	76248	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2011.10.109
	57396825	76248	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2012.02.018
	CHEMBL1933724	76248	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2012.02.018
	57394893	78081	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957435	78081	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
	57394893	78081	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957435	78081	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
	51039072	135984	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	4	5	4.3	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2ccc(C(=O)NO)o2)cc1	nan
	CHEMBL3670662	135984	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	4	5	4.3	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2ccc(C(=O)NO)o2)cc1	nan
	9807448	209951	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
	CHEMBL64246	209951	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
	10315	9700	28	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to EP2 (unknown origin) assessed as inhibition constantBinding affinity to EP2 (unknown origin) assessed as inhibition constant	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1016/j.ejmech.2021.113842
	44230575	9700	28	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to EP2 (unknown origin) assessed as inhibition constantBinding affinity to EP2 (unknown origin) assessed as inhibition constant	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1016/j.ejmech.2021.113842
	CHEMBL3707245	9700	28	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to EP2 (unknown origin) assessed as inhibition constantBinding affinity to EP2 (unknown origin) assessed as inhibition constant	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1016/j.ejmech.2021.113842
	67078580	135978	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	435	6	2	5	4.7	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
	CHEMBL3670656	135978	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	435	6	2	5	4.7	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
	51039068	135980	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	436	6	4	5	4.0	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
	CHEMBL3670658	135980	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	436	6	4	5	4.0	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
	44304164	210013	0	None	-	1	Mouse	7.5	pKi	=	7.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64483	210013	0	None	-	1	Mouse	7.5	pKi	=	7.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	15947857	162292	7	None	-269	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	767	12	1	9	6.3	COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1	10.1016/j.bmcl.2008.01.103
	CHEMBL404199	162292	7	None	-269	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	767	12	1	9	6.3	COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1	10.1016/j.bmcl.2008.01.103
	44320294	112784	0	None	-4	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	557	12	1	6	5.7	O=S(=O)(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL313266	112784	0	None	-4	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	557	12	1	6	5.7	O=S(=O)(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	230826	100206	32	None	-19	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity at prostanoid EP2 receptorBinding affinity at prostanoid EP2 receptor	ChEMBL	268	4	1	2	3.9	O=C(O)COc1ccc(Cl)cc1C1CCCCC1	10.1016/j.bmcl.2007.05.019
	CHEMBL245908	100206	32	None	-19	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity at prostanoid EP2 receptorBinding affinity at prostanoid EP2 receptor	ChEMBL	268	4	1	2	3.9	O=C(O)COc1ccc(Cl)cc1C1CCCCC1	10.1016/j.bmcl.2007.05.019
	44269516	50407	30	None	-87	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CCC1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	CHEMBL15096	50407	30	None	-87	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CCC1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	10413147	15852	0	None	-13182	3	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	486	10	3	3	7.2	Cc1cc(C)cc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
	CHEMBL1099047	15852	0	None	-13182	3	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	486	10	3	3	7.2	Cc1cc(C)cc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
	44444720	101002	0	None	-239	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249953	101002	0	None	-239	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
	11855870	153058	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	153058	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855870	153058	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	153058	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11269563	148388	0	None	-281	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	399	5	1	3	5.2	CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	CHEMBL385126	148388	0	None	-281	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	399	5	1	3	5.2	CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	10185382	71189	0	None	-30	5	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	1	7	4.6	COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL1813119	71189	0	None	-30	5	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	1	7	4.6	COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	9867899	209903	0	None	-97	3	Mouse	5.5	pKi	=	5.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	440	13	3	5	3.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2CCSCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	CHEMBL64072	209903	0	None	-97	3	Mouse	5.5	pKi	=	5.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	440	13	3	5	3.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2CCSCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	44303590	209690	0	None	-363	3	Mouse	5.5	pKi	=	5.5	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	468	14	3	7	2.6	COCCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	CHEMBL62779	209690	0	None	-363	3	Mouse	5.5	pKi	=	5.5	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	468	14	3	7	2.6	COCCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	21362867	113879	0	None	-128	4	Human	4.5	pKi	=	4.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	417	7	1	5	4.6	CSc1cccc(-c2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL315974	113879	0	None	-128	4	Human	4.5	pKi	=	4.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	417	7	1	5	4.6	CSc1cccc(-c2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/s0960-894x(02)00518-8
	44269544	42026	0	None	-7762	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	359	11	2	3	3.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)Cc1ccccc1	10.1016/j.bmcl.2004.01.063
	CHEMBL14359	42026	0	None	-7762	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	359	11	2	3	3.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)Cc1ccccc1	10.1016/j.bmcl.2004.01.063
	118517488	160490	0	None	-56	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	CHEMBL3981554	160490	0	None	-56	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	118517361	160149	0	None	-218	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	CHEMBL3978590	160149	0	None	-218	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	57393339	76247	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933723	76247	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
	57393339	76247	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933723	76247	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	44290312	185699	0	None	-87	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	421	11	2	3	5.0	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL47018	185699	0	None	-87	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	421	11	2	3	5.0	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2004.01.063
	72950089	157370	0	None	-1621	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL3955128	157370	0	None	-1621	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	21974331	133324	0	None	-5	4	Mouse	6.5	pKi	=	6.5	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	399	6	1	4	4.8	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL365243	133324	0	None	-5	4	Mouse	6.5	pKi	=	6.5	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	399	6	1	4	4.8	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	10363130	107812	1	None	3	2	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL294585	107812	1	None	3	2	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	10185612	71187	0	None	-11	4	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL1813117	71187	0	None	-11	4	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	11338015	72892	0	None	-1	2	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	381	7	2	5	4.2	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(O)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL183983	72892	0	None	-1	2	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	381	7	2	5	4.2	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(O)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	44303967	209737	0	None	-	1	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	12	3	4	4.8	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL62987	209737	0	None	-	1	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	12	3	4	4.8	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCCC1	10.1016/s0960-894x(01)00359-6
	10294290	206832	0	None	-275	4	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	398	8	1	4	4.8	O=C(O)/C=C/c1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL595632	206832	0	None	-275	4	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	398	8	1	4	4.8	O=C(O)/C=C/c1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	50898361	63647	0	None	-2630	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	549	7	2	5	5.4	Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(=O)N(C)C)sc4c(C)cc(C)cc34)cc2)cc1	10.1016/j.bmcl.2010.11.118
	CHEMBL1644003	63647	0	None	-2630	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	549	7	2	5	5.4	Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(=O)N(C)C)sc4c(C)cc(C)cc34)cc2)cc1	10.1016/j.bmcl.2010.11.118
	44304474	209710	0	None	-91	5	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL62868	209710	0	None	-91	5	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O	10.1016/s0960-894x(01)00365-1
	10277744	71186	0	None	-12	7	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL1813116	71186	0	None	-12	7	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	10291963	91483	0	None	-199	6	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2011.10.109
	CHEMBL222715	91483	0	None	-199	6	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2011.10.109
	11476788	168053	0	None	-23	6	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	463	5	1	5	4.4	CS(=O)(=O)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1)c1n2CCC[C@@H]1CC(=O)O	10.1016/j.bmcl.2008.03.015
	CHEMBL412070	168053	0	None	-23	6	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	463	5	1	5	4.4	CS(=O)(=O)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1)c1n2CCC[C@@H]1CC(=O)O	10.1016/j.bmcl.2008.03.015
	92135977	159675	0	None	-275	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	CHEMBL3974652	159675	0	None	-275	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	11405770	144686	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	361	11	2	3	3.6	CCCCC[C@H](O)CC[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
	CHEMBL376347	144686	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	361	11	2	3	3.6	CCCCC[C@H](O)CC[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
	21362910	23697	0	None	-5	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	9	1	2	7.0	O=C(O)CCCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL125269	23697	0	None	-5	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	9	1	2	7.0	O=C(O)CCCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	57893867	81932	0	None	-12302	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	492	12	3	4	4.9	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3[nH]ccc3c2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036311	81932	0	None	-12302	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	492	12	3	4	4.9	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3[nH]ccc3c2)c1	10.1016/j.bmc.2012.04.008
	56658144	71580	0	None	1	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(NC(=O)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819605	71580	0	None	1	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(NC(=O)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	44349531	23337	0	None	-3	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	394	7	1	2	6.2	O=C(O)Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL123844	23337	0	None	-3	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	394	7	1	2	6.2	O=C(O)Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	21362849	175107	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	8	1	2	6.9	CC(Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
	CHEMBL434247	175107	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	8	1	2	6.9	CC(Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
	44269464	41251	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	CHEMBL14286	41251	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	118517489	150469	0	None	-44	2	Human	5.4	pKi	=	5.4	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	CHEMBL3900245	150469	0	None	-44	2	Human	5.4	pKi	=	5.4	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	44304417	208889	0	None	-138	4	Mouse	6.4	pKi	=	6.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	438	13	3	4	4.3	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	CHEMBL60894	208889	0	None	-138	4	Mouse	6.4	pKi	=	6.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	438	13	3	4	4.3	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	44303723	209714	0	None	-	1	Mouse	6.4	pKi	=	6.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL62885	209714	0	None	-	1	Mouse	6.4	pKi	=	6.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
	53358922	71204	0	None	-70	6	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	522	6	1	6	5.3	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
	CHEMBL1813276	71204	0	None	-70	6	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	522	6	1	6	5.3	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
	21362851	123682	0	None	-67	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL338388	123682	0	None	-67	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	10109445	91918	0	None	-537	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	365	10	2	4	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)s1	10.1021/jm049290a
	CHEMBL224970	91918	0	None	-537	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	365	10	2	4	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)s1	10.1021/jm049290a
	1883	9856	75	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	1916	9856	75	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	5280360	9856	75	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	913	9856	75	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	CHEMBL548	9856	75	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	DB00917	9856	75	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	5283086	210089	24	None	-269	5	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
	CHEMBL64804	210089	24	None	-269	5	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
	10271490	172672	0	None	-29	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	9	1	2	5.8	Cc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL424975	172672	0	None	-29	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	9	1	2	5.8	Cc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	44320433	174722	0	None	-45	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccccc1CSCCc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL431612	174722	0	None	-45	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccccc1CSCCc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	24953283	206227	0	None	-426	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	CHEMBL591431	206227	0	None	-426	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	11855594	159759	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	159759	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855594	159759	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	159759	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11294166	83820	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
	CHEMBL207203	83820	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
	11294166	83820	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	CHEMBL207203	83820	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	22009003	129394	0	None	-436	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(C(O)/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	CHEMBL360290	129394	0	None	-436	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(C(O)/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	44304008	210021	0	None	-549	4	Mouse	5.4	pKi	=	5.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	410	11	3	6	2.4	O=C(O)CSCCCS[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)Cc1ccccc1	10.1016/s0960-894x(01)00364-x
	CHEMBL64542	210021	0	None	-549	4	Mouse	5.4	pKi	=	5.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	410	11	3	6	2.4	O=C(O)CSCCCS[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)Cc1ccccc1	10.1016/s0960-894x(01)00364-x
	44138108	191064	0	None	-12302	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
	CHEMBL483991	191064	0	None	-12302	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
	51039064	135979	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
	CHEMBL3670657	135979	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
	1883	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	1916	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	5280360	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	913	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	CHEMBL548	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	DB00917	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	1883	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	1916	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	5280360	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	913	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	CHEMBL548	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	DB00917	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	1883	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	1916	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	5280360	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	913	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	CHEMBL548	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	DB00917	9856	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	44304124	109400	0	None	-	1	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL304225	109400	0	None	-	1	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	11855324	149383	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	149383	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855324	149383	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	149383	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	44269486	173621	0	None	-144	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	CHEMBL428524	173621	0	None	-144	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	138	9855	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	149351	9855	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	1882	9855	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	5280723	9855	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL495	9855	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	DB00770	9855	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	138	9855	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	149351	9855	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	1882	9855	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	5280723	9855	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL495	9855	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	DB00770	9855	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	10183680	133944	0	None	-2	3	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL365696	133944	0	None	-2	3	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	11597294	172955	4	None	-489	8	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	4	1	2	5.7	O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21	10.1021/jm0603668
	CHEMBL426387	172955	4	None	-489	8	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	4	1	2	5.7	O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21	10.1021/jm0603668
	57391585	76242	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933718	76242	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmcl.2011.10.109
	57391585	76242	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933718	76242	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmc.2012.02.018
	10112486	23673	0	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1ccc(-c2ccccc2OCc2ccccc2)s1	10.1016/s0960-894x(03)00794-7
	CHEMBL125110	23673	0	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1ccc(-c2ccccc2OCc2ccccc2)s1	10.1016/s0960-894x(03)00794-7
	44390831	70411	0	None	-575	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	8	1	2	6.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccc(F)cc1	10.1016/j.bmcl.2004.11.051
	CHEMBL180089	70411	0	None	-575	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	8	1	2	6.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccc(F)cc1	10.1016/j.bmcl.2004.11.051
	44289969	108155	0	None	-17	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	345	10	2	3	3.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccccc1	10.1016/j.bmcl.2004.01.063
	CHEMBL297139	108155	0	None	-17	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	345	10	2	3	3.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccccc1	10.1016/j.bmcl.2004.01.063
	57398586	76251	0	None	-53	3	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	422	9	2	7	3.0	Cc1ccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)o1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933727	76251	0	None	-53	3	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	422	9	2	7	3.0	Cc1ccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)o1	10.1016/j.bmcl.2011.10.109
	44290262	185298	0	None	-10	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccc(Cl)cc2)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL46671	185298	0	None	-10	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccc(Cl)cc2)c1	10.1016/j.bmcl.2004.01.063
	44290272	108220	0	None	-6760	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2Cl)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL297578	108220	0	None	-6760	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2Cl)c1	10.1016/j.bmcl.2004.01.063
	44442327	101234	0	None	-147	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL251294	101234	0	None	-147	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	71462285	88655	0	None	-239	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	478	10	1	5	6.0	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
	CHEMBL2164608	88655	0	None	-239	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	478	10	1	5	6.0	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
	44303711	109129	0	None	18	3	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL303763	109129	0	None	18	3	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	24953285	207648	0	None	-53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	453	6	2	3	5.9	O=C(O)c1ccc(CNC(=O)c2c(Cl)sc(Cl)c2Cc2cccc(Cl)c2)cc1	10.1021/jm901771h
	CHEMBL601299	207648	0	None	-53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	453	6	2	3	5.9	O=C(O)c1ccc(CNC(=O)c2c(Cl)sc(Cl)c2Cc2cccc(Cl)c2)cc1	10.1021/jm901771h
	155520370	177255	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2ccc3cc(C(=O)O)oc3c2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4448995	177255	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2ccc3cc(C(=O)O)oc3c2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	56665068	71598	0	None	-3	4	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	2	5	5.1	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819622	71598	0	None	-3	4	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	2	5	5.1	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	10269242	162354	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL404413	162354	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	21974528	131228	0	None	-22	5	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	441	6	1	5	4.6	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Cc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL363984	131228	0	None	-22	5	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	441	6	1	5	4.6	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Cc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	44289922	170303	0	None	-954	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/j.bmcl.2004.01.063
	CHEMBL42027	170303	0	None	-954	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/j.bmcl.2004.01.063
	10227492	23670	0	None	-218	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	476	8	1	2	7.9	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2c(Cl)cccc2Cl)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL125087	23670	0	None	-218	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	476	8	1	2	7.9	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2c(Cl)cccc2Cl)c1	10.1016/s0960-894x(03)00794-7
	44349528	120578	0	None	-131	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	7.2	CC(CC(=O)O)c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL332446	120578	0	None	-131	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	7.2	CC(CC(=O)O)c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	59465601	156673	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3949271	156673	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	24953286	208163	0	None	-151	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(Cl)c1	10.1021/jm901771h
	CHEMBL604546	208163	0	None	-151	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(Cl)c1	10.1021/jm901771h
	54013831	153238	0	None	3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3922151	153238	0	None	3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	9845064	76123	0	None	-194	3	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	420	13	2	5	3.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)[C@@H]2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929528	76123	0	None	-194	3	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	420	13	2	5	3.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)[C@@H]2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	11395329	130625	0	None	-17	2	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL362541	130625	0	None	-17	2	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	9885106	91548	0	None	-2344	6	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1021/jm049290a
	CHEMBL223151	91548	0	None	-2344	6	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1021/jm049290a
	44304389	209932	0	None	-40	4	Mouse	7.3	pKi	=	7.3	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCSCC(=O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL64188	209932	0	None	-40	4	Mouse	7.3	pKi	=	7.3	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCSCC(=O)O	10.1016/s0960-894x(01)00365-1
	10168694	213128	0	None	-309	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	671	17	1	7	8.2	O=C(CCc1ccccc1-c1ccc(OCCCOc2cccc(CSCCc3ccccc3)c2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL87366	213128	0	None	-309	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	671	17	1	7	8.2	O=C(CCc1ccccc1-c1ccc(OCCCOc2cccc(CSCCc3ccccc3)c2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	12521	8978	0	None	-20892	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	72722131	8978	0	None	-20892	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	CHEMBL3918816	8978	0	None	-20892	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	1929	8386	55	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	9890801	8386	55	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	CHEMBL563646	8386	55	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	DB12022	8386	55	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	10299717	71191	0	None	-144	6	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21	10.1016/j.bmc.2011.06.014
	CHEMBL1813120	71191	0	None	-144	6	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21	10.1016/j.bmc.2011.06.014
	59465588	150304	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3898887	150304	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465575	151845	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
	CHEMBL3911438	151845	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
	59465592	156481	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3947785	156481	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
	59465590	157724	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3957958	157724	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465584	158209	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
	CHEMBL3961847	158209	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
	11855325	151469	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	151469	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855325	151469	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	151469	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	57564500	157989	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959926	157989	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	12137443	91478	0	None	-5495	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	491	9	2	3	6.1	Cc1cc(Cl)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
	CHEMBL222677	91478	0	None	-5495	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	491	9	2	3	6.1	Cc1cc(Cl)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
	11224239	71578	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819603	71578	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	11282034	73404	0	None	-13	3	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	437	11	1	5	5.6	CCCCOc1ccc(C(=O)n2c(C)c(CCCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL185277	73404	0	None	-13	3	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	437	11	1	5	5.6	CCCCOc1ccc(C(=O)n2c(C)c(CCCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	46887240	15526	0	None	-13489	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	472	10	3	3	6.9	Cc1cccc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
	CHEMBL1096382	15526	0	None	-13489	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	472	10	3	3	6.9	Cc1cccc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
	52945419	23306	0	None	-478	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	772	16	4	6	10.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(O)c1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237296	23306	0	None	-478	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	772	16	4	6	10.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(O)c1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	56672018	71581	0	None	-6	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	446	7	1	5	3.9	CN1C[C@@H](COc2ccc(C(=O)N(C)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819606	71581	0	None	-6	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	446	7	1	5	3.9	CN1C[C@@H](COc2ccc(C(=O)N(C)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	44303709	209979	0	None	-870	3	Mouse	5.3	pKi	=	5.3	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	470	13	3	7	3.3	CSCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	CHEMBL64338	209979	0	None	-870	3	Mouse	5.3	pKi	=	5.3	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	470	13	3	7	3.3	CSCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	59465581	150890	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3903611	150890	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	44455236	102250	0	None	-53	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	373	11	2	3	3.8	CCCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL257217	102250	0	None	-53	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	373	11	2	3	3.8	CCCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	21974448	73737	0	None	-53	4	Mouse	6.3	pKi	=	6.3	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	429	8	1	5	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCOc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL186735	73737	0	None	-53	4	Mouse	6.3	pKi	=	6.3	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	429	8	1	5	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCOc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	11155228	72880	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	CHEMBL183919	72880	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	44419347	89550	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1ccc(OCc2c(Cl)cccc2Cl)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL217988	89550	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1ccc(OCc2c(Cl)cccc2Cl)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	10298293	100942	0	None	-426	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249538	100942	0	None	-426	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
	52944193	23305	0	None	-63	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237295	23305	0	None	-63	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	21362905	178086	0	None	-8	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	6.9	CC(Cc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
	CHEMBL446098	178086	0	None	-8	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	6.9	CC(Cc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
	58932683	82062	0	None	-354	3	Mouse	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
	CHEMBL2037289	82062	0	None	-354	3	Mouse	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
	44444716	161616	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	484	12	1	3	5.4	CC(CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1)Cc1cccc(CCc2ccccc2)c1	10.1016/j.bmcl.2007.09.074
	CHEMBL400447	161616	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	484	12	1	3	5.4	CC(CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1)Cc1cccc(CCc2ccccc2)c1	10.1016/j.bmcl.2007.09.074
	10295421	100972	0	None	-316	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	416	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249744	100972	0	None	-316	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	416	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.09.074
	44234032	154703	0	None	-81	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	415	8	1	4	5.0	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1	10.1021/acs.jmedchem.6b00871
	CHEMBL3933704	154703	0	None	-81	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	415	8	1	4	5.0	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1	10.1021/acs.jmedchem.6b00871
	11165749	172738	0	None	-20	3	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL425167	172738	0	None	-20	3	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	44520990	206632	0	None	-6	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	410	6	2	4	5.3	Cc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
	CHEMBL594423	206632	0	None	-6	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	410	6	2	4	5.3	Cc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
	11855867	152761	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	152761	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855867	152761	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	152761	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	44304403	175876	0	None	-16	4	Mouse	7.2	pKi	=	7.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	420	12	3	4	3.8	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	CHEMBL439934	175876	0	None	-16	4	Mouse	7.2	pKi	=	7.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	420	12	3	4	3.8	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	44290314	180753	0	None	-5754	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	403	10	2	4	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccc(C(F)(F)F)o1	10.1016/j.bmcl.2004.01.063
	CHEMBL45418	180753	0	None	-5754	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	403	10	2	4	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccc(C(F)(F)F)o1	10.1016/j.bmcl.2004.01.063
	44320272	213041	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	507	10	1	5	5.9	O=C(Cc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL86886	213041	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	507	10	1	5	5.9	O=C(Cc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	24952929	9332	42	None	-9332	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	4041	9332	42	None	-9332	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	CHEMBL597997	9332	42	None	-9332	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	10295336	208225	0	None	-53	4	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	415	8	1	3	4.7	O=C(O)/C=C/c1ccc(CN2CCCC2=O)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL604897	208225	0	None	-53	4	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	415	8	1	3	4.7	O=C(O)/C=C/c1ccc(CN2CCCC2=O)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	44290266	168487	0	None	-8	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	353	12	3	4	2.3	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)N1C/C=C/CCCC(=O)O	10.1016/j.bmcl.2004.01.063
	CHEMBL413509	168487	0	None	-8	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	353	12	3	4	2.3	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)N1C/C=C/CCCC(=O)O	10.1016/j.bmcl.2004.01.063
	44394380	132207	0	None	-6	4	Mouse	7.2	pKi	=	7.2	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL364593	132207	0	None	-6	4	Mouse	7.2	pKi	=	7.2	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	44442337	100782	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	381	8	1	2	5.0	C/C(=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)CC1CCCC1	10.1016/j.bmcl.2007.05.025
	CHEMBL248678	100782	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	381	8	1	2	5.0	C/C(=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)CC1CCCC1	10.1016/j.bmcl.2007.05.025
	44442331	101265	0	None	-15	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251505	101265	0	None	-15	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	10278907	71192	0	None	-138	3	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
	CHEMBL1813121	71192	0	None	-138	3	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
	59465570	150037	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3896693	150037	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
	134147021	156803	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
	CHEMBL3950412	156803	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
	10204257	100944	0	None	-104	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	9	2	4	3.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249540	100944	0	None	-104	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	9	2	4	3.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
	44219292	119359	38	None	-204	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	431	8	1	4	5.5	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.6b00871
	CHEMBL3301604	119359	38	None	-204	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	431	8	1	4	5.5	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.6b00871
	CHEMBL3919269	119359	38	None	-204	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	431	8	1	4	5.5	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.6b00871
	DB12462	119359	38	None	-204	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	431	8	1	4	5.5	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.6b00871
	57400087	78077	0	None	-2	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	8	2	3	4.0	O=C(O)CCc1cccc(N2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1957431	78077	0	None	-2	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	8	2	3	4.0	O=C(O)CCc1cccc(N2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)c1	10.1016/j.bmc.2012.02.018
	57893916	81930	0	None	-1288	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	454	12	2	5	3.8	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccccn2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036309	81930	0	None	-1288	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	454	12	2	5	3.8	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccccn2)c1	10.1016/j.bmc.2012.04.008
	56672019	71588	0	None	-7	4	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1	10.1016/j.bmc.2011.08.007
	CHEMBL1819612	71588	0	None	-7	4	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1	10.1016/j.bmc.2011.08.007
	8541	9718	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	9824353	9718	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL292964	9718	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	8541	9718	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Binding affinity to mouse EP2 receptor by competitive binding assayBinding affinity to mouse EP2 receptor by competitive binding assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/jm9018756
	9824353	9718	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Binding affinity to mouse EP2 receptor by competitive binding assayBinding affinity to mouse EP2 receptor by competitive binding assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/jm9018756
	CHEMBL292964	9718	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Binding affinity to mouse EP2 receptor by competitive binding assayBinding affinity to mouse EP2 receptor by competitive binding assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/jm9018756
	8541	9718	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/j.bmc.2011.12.009
	9824353	9718	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/j.bmc.2011.12.009
	CHEMBL292964	9718	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/j.bmc.2011.12.009
	10221497	100914	0	None	-91	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249342	100914	0	None	-91	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
	10272306	161615	0	None	-173	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	400	9	2	4	2.5	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(F)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL400446	161615	0	None	-173	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	400	9	2	4	2.5	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(F)c2)cc1	10.1016/j.bmcl.2007.09.074
	71452690	85400	0	None	15	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	400	9	1	4	5.1	c1ccc(CCSCc2ccc(-c3ccccc3CCc3nnn[nH]3)cc2)cc1	10.1016/s0960-894x(02)00518-8
	CHEMBL2112332	85400	0	None	15	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	400	9	1	4	5.1	c1ccc(CCSCc2ccc(-c3ccccc3CCc3nnn[nH]3)cc2)cc1	10.1016/s0960-894x(02)00518-8
	52950151	23309	0	None	3	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1.Cc1cccc(C/C=C/c2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237299	23309	0	None	3	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1.Cc1cccc(C/C=C/c2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	22008967	89924	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
	CHEMBL218228	89924	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
	22008966	89925	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
	CHEMBL218229	89925	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
	13230981	41841	0	None	-1122	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	339	13	2	3	3.5	CCCCCC(O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	CHEMBL14334	41841	0	None	-1122	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	339	13	2	3	3.5	CCCCCC(O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	10348006	82065	0	None	-338	3	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	569	10	2	8	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2037292	82065	0	None	-338	3	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	569	10	2	8	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	52943000	23307	0	None	-26	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237297	23307	0	None	-26	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	10319835	76142	0	None	-16982	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	417	13	2	3	4.9	CCCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929547	76142	0	None	-16982	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	417	13	2	3	4.9	CCCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	44520991	206481	0	None	-7	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	426	7	2	5	5.0	COc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
	CHEMBL593260	206481	0	None	-7	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	426	7	2	5	5.0	COc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
	44289977	169538	0	None	-478	2	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	413	10	2	3	4.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL417171	169538	0	None	-478	2	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	413	10	2	3	4.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	12003887	78074	0	None	-776	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	411	11	2	4	3.4	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(Cl)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1957308	78074	0	None	-776	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	411	11	2	4	3.4	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(Cl)c1	10.1016/j.bmc.2012.02.018
	67078970	135977	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	416	6	3	5	4.4	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
	CHEMBL3670655	135977	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	416	6	3	5	4.4	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
	25114442	9835	56	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.1021/acs.jmedchem.1c00816
	5817	9835	56	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.1021/acs.jmedchem.1c00816
	CHEMBL3286797	9835	56	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.1021/acs.jmedchem.1c00816
	DB12024	9835	56	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.1021/acs.jmedchem.1c00816
	59465571	153063	0	None	21	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3920796	153063	0	None	21	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	59465600	158477	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3964261	158477	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	21362845	113680	0	None	-630	4	Human	4.2	pKi	=	4.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	556	7	1	5	7.3	O=C(/C=C/c1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL314616	113680	0	None	-630	4	Human	4.2	pKi	=	4.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	556	7	1	5	7.3	O=C(/C=C/c1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	52943002	23311	0	None	-2	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	716	14	2	4	11.1	Cc1cccc(/C=C\Cc2ccccc2C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237301	23311	0	None	-2	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	716	14	2	4	11.1	Cc1cccc(/C=C\Cc2ccccc2C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	67245477	151661	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
	CHEMBL3909989	151661	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
	44289921	171150	0	None	-9332	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	365	11	2	3	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)CC1CCCCC1	10.1016/j.bmcl.2004.01.063
	CHEMBL42129	171150	0	None	-9332	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	365	11	2	3	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)CC1CCCCC1	10.1016/j.bmcl.2004.01.063
	57893891	81934	0	None	-1995	2	Mouse	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	510	12	2	6	5.0	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3s2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036313	81934	0	None	-1995	2	Mouse	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	510	12	2	6	5.0	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3s2)c1	10.1016/j.bmc.2012.04.008
	24952929	9332	42	None	-11481	5	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	4041	9332	42	None	-11481	5	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	CHEMBL597997	9332	42	None	-11481	5	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	1892	7534	20	None	-2	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	25886893	7534	20	None	-2	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	CHEMBL1628262	7534	20	None	-2	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	44304181	210052	0	None	12	2	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64663	210052	0	None	12	2	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	9965922	70651	0	None	-724	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	294	5	2	2	4.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1O	10.1016/j.bmcl.2004.11.051
	CHEMBL180389	70651	0	None	-724	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	294	5	2	2	4.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1O	10.1016/j.bmcl.2004.11.051
	24765153	191308	0	None	-11481	8	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
	CHEMBL484778	191308	0	None	-11481	8	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
	9910141	107652	0	None	-1513	3	Mouse	5.1	pKi	=	5.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	11	4	6	2.7	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCSCCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
	CHEMBL293647	107652	0	None	-1513	3	Mouse	5.1	pKi	=	5.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	11	4	6	2.7	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCSCCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
	118517485	149528	0	None	-50	2	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	CHEMBL3892492	149528	0	None	-50	2	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	24952580	207341	0	None	-575	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	CHEMBL599052	207341	0	None	-575	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	10452108	100783	0	None	-25	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	375	7	1	2	4.6	C/C(=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)c1ccccc1	10.1016/j.bmcl.2007.05.025
	CHEMBL248679	100783	0	None	-25	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	375	7	1	2	4.6	C/C(=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)c1ccccc1	10.1016/j.bmcl.2007.05.025
	44304388	209931	0	None	-151	5	Mouse	7.1	pKi	=	7.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL64187	209931	0	None	-151	5	Mouse	7.1	pKi	=	7.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	11440167	91493	0	None	-75	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	371	9	2	3	3.4	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
	CHEMBL222782	91493	0	None	-75	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	371	9	2	3	3.4	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
	44444722	101031	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
	CHEMBL250153	101031	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
	52945294	23319	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237317	23319	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	52945294	23319	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL1237317	23319	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	10111602	90003	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	400	9	1	3	5.6	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL218626	90003	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	400	9	1	3	5.6	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	22990263	23565	0	None	-4	3	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	292	3	1	1	4.8	O=C(O)/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL124574	23565	0	None	-4	3	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	292	3	1	1	4.8	O=C(O)/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(03)00794-7
	10410111	109618	0	None	-398	3	Mouse	6.1	pKi	=	6.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	CHEMBL305568	109618	0	None	-398	3	Mouse	6.1	pKi	=	6.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	44304009	107512	0	None	-1479	3	Mouse	5.1	pKi	=	5.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	482	15	3	7	3.3	CCCOCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	CHEMBL292717	107512	0	None	-1479	3	Mouse	5.1	pKi	=	5.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	482	15	3	7	3.3	CCCOCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	11210487	71068	0	None	177	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	356	7	1	2	5.5	O=C(O)/C=C/c1ccccc1/C=C/c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL181035	71068	0	None	177	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	356	7	1	2	5.5	O=C(O)/C=C/c1ccccc1/C=C/c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	16725337	156380	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	156380	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	16725337	156380	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	156380	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	24953625	208311	0	None	-323	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(C(F)(F)F)c1	10.1021/jm901771h
	CHEMBL605330	208311	0	None	-323	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(C(F)(F)F)c1	10.1021/jm901771h
	10302378	89554	0	None	-6606	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	539	9	1	5	6.6	O=C(/C=C/c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	CHEMBL217991	89554	0	None	-6606	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	539	9	1	5	6.6	O=C(/C=C/c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	22009006	148342	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1/C=C/Cc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	CHEMBL384878	148342	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1/C=C/Cc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	9953337	148438	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1C/C=C/c1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	CHEMBL385396	148438	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1C/C=C/c1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	25003075	13610	18	None	-28183	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting	ChEMBL	478	6	2	3	5.8	O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1	10.1016/j.bmcl.2010.04.065
	CHEMBL1084009	13610	18	None	-28183	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting	ChEMBL	478	6	2	3	5.8	O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1	10.1016/j.bmcl.2010.04.065
	10247632	84766	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL2096894	84766	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	10178073	23331	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/s0960-894x(03)00794-7
	CHEMBL123794	23331	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/s0960-894x(03)00794-7
	9944231	24807	0	None	-10	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	302	5	1	1	5.0	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL126472	24807	0	None	-10	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	302	5	1	1	5.0	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	10178073	23331	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL123794	23331	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	12112238	124849	0	None	-10	4	Human	6.1	pKi	=	6.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	406	7	1	2	6.7	O=C(O)/C=C/c1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL340501	124849	0	None	-10	4	Human	6.1	pKi	=	6.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	406	7	1	2	6.7	O=C(O)/C=C/c1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	44444715	100973	0	None	-25	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	12	2	4	3.7	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(CCC3CC3)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249745	100973	0	None	-25	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	12	2	4	3.7	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(CCC3CC3)c2)cc1	10.1016/j.bmcl.2007.09.074
	57398585	76245	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933721	76245	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
	57398585	76245	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933721	76245	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	56834112	76122	0	None	-1071	2	Mouse	5.1	pKi	=	5.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	421	13	2	5	2.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929527	76122	0	None	-1071	2	Mouse	5.1	pKi	=	5.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	421	13	2	5	2.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	44290271	185827	0	None	-204	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2cccc(Cl)c2)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL47138	185827	0	None	-204	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2cccc(Cl)c2)c1	10.1016/j.bmcl.2004.01.063
	52944193	23305	0	None	-63	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237295	23305	0	None	-63	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	44419374	89770	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL218123	89770	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	44419379	144641	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL376053	144641	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	44320388	213187	0	None	-56	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	536	11	2	6	5.8	Cc1cccc(OCCCOc2ccc(-c3ccccc3CNC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL87797	213187	0	None	-56	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	536	11	2	6	5.8	Cc1cccc(OCCCOc2ccc(-c3ccccc3CNC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	9954562	90912	0	None	-478	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	433	6	1	4	5.0	O=C(/C=C/c1ccccc1Cc1ccc2ccccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	CHEMBL220802	90912	0	None	-478	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	433	6	1	4	5.0	O=C(/C=C/c1ccccc1Cc1ccc2ccccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	138	9855	88	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	149351	9855	88	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	1882	9855	88	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	5280723	9855	88	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	CHEMBL495	9855	88	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	DB00770	9855	88	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	52945423	23313	0	None	-33	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	824	18	2	6	11.6	CC(=O)c1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1.CC(=O)c1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237303	23313	0	None	-33	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	824	18	2	6	11.6	CC(=O)c1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1.CC(=O)c1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2004.11.051
	22009008	89932	0	None	-5495	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL218280	89932	0	None	-5495	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	22009004	148529	0	None	-2884	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL385955	148529	0	None	-2884	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	132836	66469	23	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL1722929	66469	23	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	44442332	101302	0	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251709	101302	0	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	44393680	73119	0	None	-4	2	Mouse	5.1	pKi	=	5.1	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	367	7	1	5	4.2	CCCCOc1ccc(C(=O)n2cc(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL185087	73119	0	None	-4	2	Mouse	5.1	pKi	=	5.1	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	367	7	1	5	4.2	CCCCOc1ccc(C(=O)n2cc(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	84973026	135986	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	441	7	4	4	4.7	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2cccc(CC(=O)NO)c2)cc1	nan
	CHEMBL3670664	135986	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	441	7	4	4	4.7	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2cccc(CC(=O)NO)c2)cc1	nan
	57894063	81940	0	None	-5	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	CHEMBL2036319	81940	0	None	-5	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	56835070	76246	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933722	76246	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
	56835070	76246	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933722	76246	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	56835070	76246	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL1933722	76246	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
	84973025	135983	5	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccc(O)cc3)cc2-c2ccoc2)cc1	nan
	CHEMBL3670661	135983	5	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccc(O)cc3)cc2-c2ccoc2)cc1	nan
	21974374	134025	0	None	-1	5	Mouse	7.1	pKi	=	7.1	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	5.0	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2CCc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL365829	134025	0	None	-1	5	Mouse	7.1	pKi	=	7.1	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	5.0	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2CCc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	44304334	208355	0	None	-45	5	Mouse	7.0	pKi	=	7.0	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL60555	208355	0	None	-45	5	Mouse	7.0	pKi	=	7.0	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	57396659	78076	0	None	-114	3	Mouse	7.0	pKi	=	7.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	431	9	2	5	4.0	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1957430	78076	0	None	-114	3	Mouse	7.0	pKi	=	7.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	431	9	2	5	4.0	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	44304199	107594	0	None	-	1	Mouse	7.0	pKi	=	7.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL293242	107594	0	None	-	1	Mouse	7.0	pKi	=	7.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	44444719	101001	0	None	-67	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249952	101001	0	None	-67	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
	10273914	206451	0	None	-70	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(COc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL593041	206451	0	None	-70	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(COc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	46230201	207395	0	None	-436	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	CHEMBL599355	207395	0	None	-436	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	118517485	149528	0	None	-50	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	CHEMBL3892492	149528	0	None	-50	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	118517490	159934	0	None	-125	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	CHEMBL3976710	159934	0	None	-125	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	9865111	70639	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1cccc(CCCc2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL180343	70639	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1cccc(CCCc2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	44419350	90917	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)O)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL220820	90917	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)O)c1	10.1016/j.bmcl.2006.08.025
	118517359	151174	0	None	-114	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	151174	0	None	-114	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	10116114	132664	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL364841	132664	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	10116114	132664	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.08.007
	CHEMBL364841	132664	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.08.007
	44390806	70852	0	None	-24	3	Human	6.0	pKi	=	6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	8	1	2	5.9	Cc1cccc(C2CC2c2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL180752	70852	0	None	-24	3	Human	6.0	pKi	=	6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	8	1	2	5.9	Cc1cccc(C2CC2c2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	1883	9856	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	1883	9856	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	1916	9856	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	1916	9856	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	5280360	9856	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	5280360	9856	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	913	9856	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	913	9856	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	CHEMBL548	9856	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	CHEMBL548	9856	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	DB00917	9856	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	DB00917	9856	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	1883	9856	75	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	1916	9856	75	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	5280360	9856	75	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	913	9856	75	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	CHEMBL548	9856	75	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	DB00917	9856	75	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	1883	9856	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	1883	9856	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	1916	9856	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	1916	9856	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	5280360	9856	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	5280360	9856	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	913	9856	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	913	9856	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	CHEMBL548	9856	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	CHEMBL548	9856	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	DB00917	9856	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	DB00917	9856	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	138	9855	88	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	149351	9855	88	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1882	9855	88	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	5280723	9855	88	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	CHEMBL495	9855	88	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	DB00770	9855	88	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	None	222825	0	3H-PGE2	-66	3	Mouse	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	350	11	3	3	4.1	CCCCCC(C=CC1C(CC2C1CC(=C2)CCCCC(=O)O)O)O	None
	5090	22333	106	Functional	-1348	30	Dog	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	5090	22333	106	Functional	-35	30	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	CHEMBL122	22333	106	Functional	-1348	30	Dog	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	CHEMBL122	22333	106	Functional	-35	30	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	5311035	104579	29	3H-PGE2	4	9	Mouse	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	None
	CHEMBL271896	104579	29	3H-PGE2	4	9	Mouse	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	None
	1883	9856	75	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1916	9856	75	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5280360	9856	75	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	913	9856	75	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	CHEMBL548	9856	75	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	DB00917	9856	75	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1917	7714	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	5311044	7714	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	631	7714	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	CHEMBL160629	7714	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	89077401	222823	0	3H-PGE2	-144	12	Mouse	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	360	8	3	3	3.5	CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O	None
	133126726	222824	0	3H-PGE2	-151	14	Mouse	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	350	10	3	3	4.1	CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O	None
	24868263	222824	0	3H-PGE2	-151	14	Mouse	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	350	10	3	3	4.1	CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O	None
	1440	8808	119	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	1909	8808	119	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	3715	8808	119	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	CHEMBL6	8808	119	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	DB00328	8808	119	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	None	222822	0	3H-PGE2	-9	5	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	366	12	2	3	5.2	CCCCCC(C=CC1CC2CC(C1CC=CCCCC(=O)O)S2)O	None
	None	222828	0	3H-PGE2	-2	3	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	512	11	2	4	4.6	C1CC2C(C(C1O2)CC=CCCCC(=O)O)C=CC(COC3=CC=C(C=C3)I)O	None
	1928	7105	0	3H-PGE2	-3	3	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	None
	5310998	7105	0	3H-PGE2	-3	3	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	None
	1817	9320	68	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	1936	9320	68	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	5282381	9320	68	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	CHEMBL606	9320	68	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	DB00929	9320	68	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	1440	8808	119	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	1440	8808	119	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	1909	8808	119	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	1909	8808	119	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	3715	8808	119	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	3715	8808	119	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	CHEMBL6	8808	119	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	CHEMBL6	8808	119	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	DB00328	8808	119	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	DB00328	8808	119	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	119461	7108	72	3H-PGE2	1	10	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	None
	1896	7108	72	3H-PGE2	1	10	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	None
	CHEMBL1317823	7108	72	3H-PGE2	1	10	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	None
	5090	22333	106	Functional	-35	30	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	CHEMBL122	22333	106	Functional	-35	30	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	5090	22333	106	Functional	-35	30	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	CHEMBL122	22333	106	Functional	-35	30	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	5077	10351	79	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
	7552	10351	79	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
	9913767	10351	79	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
	CHEMBL238804	10351	79	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
	DB11362	10351	79	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
	1884	9857	52	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	5280363	9857	52	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	912	9857	52	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	CHEMBL815	9857	52	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	DB12789	9857	52	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	138107701	194243	46	None	-5	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	5311181	194243	46	None	-5	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	CHEMBL494	194243	46	None	-5	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	DB01088	194243	46	None	-5	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	138107701	194243	46	None	-5	15	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	5311181	194243	46	None	-5	15	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	CHEMBL494	194243	46	None	-5	15	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	DB01088	194243	46	None	-5	15	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	1917	7714	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	5311044	7714	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	631	7714	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	CHEMBL160629	7714	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	138107701	194243	46	None	-5	15	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	5311181	194243	46	None	-5	15	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	CHEMBL494	194243	46	None	-5	15	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	DB01088	194243	46	None	-5	15	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	1884	9857	52	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	5280363	9857	52	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	912	9857	52	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	CHEMBL815	9857	52	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	DB12789	9857	52	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	656511	224495	0	None	-1	7	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	539	6	3	8	-0.2	CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCN(C3=O)S(C)(=O)=O)C3=CC=CC=C3)C(=O)N2[C@H]1C(O)=O	None
	3356	9060	73	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
	4326	9060	73	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
	9867642	9060	73	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
	CHEMBL426559	9060	73	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
	DB11629	9060	73	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
	123619	223172	0	None	125	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
	5090	22333	106	None	28	30	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	CHEMBL122	22333	106	None	28	30	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	1817	9320	68	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	1936	9320	68	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	5282381	9320	68	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	CHEMBL606	9320	68	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	DB00929	9320	68	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	138	9855	88	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	149351	9855	88	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1882	9855	88	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	5280723	9855	88	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	CHEMBL495	9855	88	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	DB00770	9855	88	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1883	9856	75	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1916	9856	75	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5280360	9856	75	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	913	9856	75	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	CHEMBL548	9856	75	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	DB00917	9856	75	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1440	8808	119	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	1909	8808	119	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	3715	8808	119	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	CHEMBL6	8808	119	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	DB00328	8808	119	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	138	9855	88	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	149351	9855	88	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1882	9855	88	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	5280723	9855	88	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	CHEMBL495	9855	88	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	DB00770	9855	88	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	2720	10626	59	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
	5820	10626	59	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
	6918140	10626	59	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
	CHEMBL1237119	10626	59	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
	DB00374	10626	59	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
	1883	9856	75	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1916	9856	75	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5280360	9856	75	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	913	9856	75	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	CHEMBL548	9856	75	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	DB00917	9856	75	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5852	9395	55	None	-288	4	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	17545310
	9931891	9395	55	None	-288	4	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	17545310
	CHEMBL239226	9395	55	None	-288	4	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	17545310
	1895	8788	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
	6435378	8788	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
	CHEMBL236025	8788	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
	DB01088	8788	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
	1892	7534	20	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10462542
	1892	7534	20	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10634944
	25886893	7534	20	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10462542
	25886893	7534	20	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10634944
	CHEMBL1628262	7534	20	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10462542
	CHEMBL1628262	7534	20	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10634944
	1883	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	1883	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	1883	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	1916	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	1916	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	1916	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	5280360	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	5280360	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	5280360	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	913	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	913	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	913	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	CHEMBL548	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	CHEMBL548	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	CHEMBL548	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	DB00917	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	DB00917	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	DB00917	9856	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	1883	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	1883	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	1883	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	1916	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	1916	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	1916	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	5280360	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	5280360	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	5280360	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	913	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	913	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	913	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	CHEMBL548	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	CHEMBL548	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	CHEMBL548	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	DB00917	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	DB00917	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	DB00917	9856	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	138	9855	88	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	138	9855	88	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	149351	9855	88	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	149351	9855	88	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	1882	9855	88	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	1882	9855	88	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	5280723	9855	88	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	5280723	9855	88	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	CHEMBL495	9855	88	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	CHEMBL495	9855	88	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	DB00770	9855	88	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	DB00770	9855	88	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	138	9855	88	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	149351	9855	88	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	1882	9855	88	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	5280723	9855	88	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	CHEMBL495	9855	88	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	DB00770	9855	88	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	1883	9856	75	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	1916	9856	75	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	5280360	9856	75	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	913	9856	75	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	CHEMBL548	9856	75	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	DB00917	9856	75	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	10110	9861	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	2	3	4.3	OC(=O)COc1cccc(c1)NC(=O)c1cc(ccc1F)c1cccc(c1)F	30341781
	59654860	9861	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	2	3	4.3	OC(=O)COc1cccc(c1)NC(=O)c1cc(ccc1F)c1cccc(c1)F	30341781
	2720	10626	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
	2720	10626	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
	5820	10626	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
	5820	10626	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
	6918140	10626	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
	6918140	10626	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
	CHEMBL1237119	10626	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
	CHEMBL1237119	10626	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
	DB00374	10626	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
	DB00374	10626	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
	10315	9700	28	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	29332128
	44230575	9700	28	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	29332128
	CHEMBL3707245	9700	28	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	29332128
	1932	9716	5	None	-1	6	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10746663
	5311228	9716	5	None	-1	6	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10746663
	CHEMBL3286796	9716	5	None	-1	6	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10746663
	1888	10672	29	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
	1974	10672	29	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
	5311493	10672	29	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
	CHEMBL521784	10672	29	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
	1817	9320	68	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
	1936	9320	68	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
	5282381	9320	68	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
	CHEMBL606	9320	68	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
	DB00929	9320	68	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
	1881	9853	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	1891	9853	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	448457	9853	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	CHEMBL1235252	9853	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	DB02056	9853	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	1888	10672	29	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
	1974	10672	29	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
	5311493	10672	29	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
	CHEMBL521784	10672	29	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
	1881	9853	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	1891	9853	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	448457	9853	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	CHEMBL1235252	9853	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	DB02056	9853	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	1931	9720	0	None	-371	2	Mouse	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	14	1	4	4.6	CCCCC[C@@H](/C=C/[C@H]1[C@H](OC)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)OC	10746663
	5311229	9720	0	None	-371	2	Mouse	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	14	1	4	4.6	CCCCC[C@@H](/C=C/[C@H]1[C@H](OC)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)OC	10746663
	1884	9857	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	1884	9857	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
	5280363	9857	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	5280363	9857	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
	912	9857	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	912	9857	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
	CHEMBL815	9857	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	CHEMBL815	9857	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
	DB12789	9857	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	DB12789	9857	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
	1884	9857	52	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	5280363	9857	52	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	912	9857	52	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	CHEMBL815	9857	52	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	DB12789	9857	52	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	1913	9242	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10462542
	1913	9242	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10634944
	5311223	9242	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10462542
	5311223	9242	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10634944
	1895	8788	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
	6435378	8788	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
	CHEMBL236025	8788	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
	DB01088	8788	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
	1933	9717	0	None	-199	3	Mouse	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	468	14	3	7	2.9	COCc1ccccc1CC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O)O	10746663
	5311230	9717	0	None	-199	3	Mouse	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	468	14	3	7	2.9	COCc1ccccc1CC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O)O	10746663
	1893	7582	0	None	-112	13	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	9313928
	5311242	7582	0	None	-112	13	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	9313928
	CHEMBL148319	7582	0	None	-112	13	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	9313928
	1895	8788	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
	6435378	8788	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
	CHEMBL236025	8788	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
	DB01088	8788	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
	1947	6817	0	None	-39	3	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	8078484
	5283038	6817	0	None	-39	3	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	8078484
	119461	7108	72	None	-3	10	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10634944
	1896	7108	72	None	-3	10	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10634944
	CHEMBL1317823	7108	72	None	-3	10	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10634944
	1917	7714	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
	5311044	7714	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
	631	7714	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
	CHEMBL160629	7714	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
	1913	9242	0	None	-8912	15	Rat	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	9537820
	5311223	9242	0	None	-8912	15	Rat	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	9537820
	1928	7105	0	None	-12	3	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	10462542
	5310998	7105	0	None	-12	3	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	10462542
	1893	7582	0	None	-70	13	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	10634944
	5311242	7582	0	None	-70	13	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	10634944
	CHEMBL148319	7582	0	None	-70	13	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	10634944
	1934	8871	0	None	-63	3	Mouse	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	11	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O	9313928
	5311244	8871	0	None	-63	3	Mouse	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	11	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O	9313928
	CHEMBL4522827	8871	0	None	-63	3	Mouse	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	11	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O	9313928
	1912	6815	0	None	-213	6	Rat	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	11	3	4	3.3	OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O	9537820
	5283068	6815	0	None	-213	6	Rat	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	11	3	4	3.3	OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O	9537820
	CHEMBL1879970	6815	0	None	-213	6	Rat	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	11	3	4	3.3	OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O	9537820
	1930	10106	25	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
	9803828	10106	25	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
	CHEMBL303960	10106	25	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
	DB16315	10106	25	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
	119461	7108	72	None	-1	10	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9537820
	1896	7108	72	None	-1	10	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9537820
	CHEMBL1317823	7108	72	None	-1	10	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9537820
	119461	7108	72	None	1	10	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9313928
	1896	7108	72	None	1	10	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9313928
	CHEMBL1317823	7108	72	None	1	10	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9313928
	1928	7105	0	None	-3	3	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	9313928
	5310998	7105	0	None	-3	3	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	9313928
	1947	6817	0	None	-5	3	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	9537820
	5283038	6817	0	None	-5	3	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	9537820
	1892	7534	20	None	2	9	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	25886893	7534	20	None	2	9	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	CHEMBL1628262	7534	20	None	2	9	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	1925	6796	0	None	-39	6	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	5283055	6796	0	None	-39	6	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	CHEMBL3246389	6796	0	None	-39	6	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	1925	6796	0	None	-25	6	Rat	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	5283055	6796	0	None	-25	6	Rat	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	CHEMBL3246389	6796	0	None	-25	6	Rat	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	1935	9319	0	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	13	3	4	3.9	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)(O)C	10634944
	6436406	9319	0	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	13	3	4	3.9	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)(O)C	10634944
	CHEMBL1201377	9319	0	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	13	3	4	3.9	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)(O)C	10634944
	1926	6813	0	None	-8	3	Mouse	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	12	3	4	3.9	CCCCC([C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)(C)C	9313928
	5283066	6813	0	None	-8	3	Mouse	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	12	3	4	3.9	CCCCC([C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)(C)C	9313928
	CHEMBL1221529	6813	0	None	-8	3	Mouse	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	12	3	4	3.9	CCCCC([C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)(C)C	9313928

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Ligand source activities (1 row/activity)