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Ligand source activities (1 row/activity)
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
11-deoxy-PGE1 | 7 | None | 0 | Rat | Binding | pKi | None | - | 7.50 | -25 | 6 | Unclassified | Guide to Pharmacology | 338.2 | 13 | 2 | 3 | 4.50 | CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O | https://pubmed.ncbi.nlm.nih.gov/9537820 | |
11-deoxy-PGE1 | 7 | None | 0 | Mouse | Binding | pKi | None | - | 7.30 | -39 | 6 | Unclassified | Guide to Pharmacology | 338.2 | 13 | 2 | 3 | 4.50 | CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O | https://pubmed.ncbi.nlm.nih.gov/9313928 | |
13,14-dihydro-16-m-chlorophenoxy-w-tetranor-PGF1α | 16 | None | 0 | Human | Binding | IC50 | = | 6700.00 | 5.17 | - | 5 | Affinity for Prostanoid EP2 receptor expressed in CHO cells | ChEMBL | 428.2 | 13 | 4 | 5 | 3.64 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)COc1cccc(Cl)c1 | https://dx.doi.org/10.1021/jm990542v | |
16,16-dimethyl-PGE2 | 24 | None | 0 | Mouse | Binding | pKi | None | - | 7.80 | -8 | 3 | Unclassified | Guide to Pharmacology | 380.3 | 12 | 3 | 4 | 3.89 | CCCCC(C)(C)[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O | https://pubmed.ncbi.nlm.nih.gov/9313928 | |
17-phenyl-ω-trinor-PGE2 | 26 | None | 0 | Rat | Binding | pKi | None | - | 6.10 | -213 | 7 | Unclassified | Guide to Pharmacology | 386.2 | 11 | 3 | 4 | 3.30 | O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCc1ccccc1 | https://pubmed.ncbi.nlm.nih.gov/9537820 | |
19(R)-OH-PGE2 | 28 | None | 0 | Human | Binding | pKi | None | - | 5.90 | -39 | 3 | Unclassified | Guide to Pharmacology | 368.2 | 12 | 4 | 5 | 2.22 | C[C@@H](O)CCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O | https://pubmed.ncbi.nlm.nih.gov/8078484 | |
19(R)-OH-PGE2 | 28 | None | 0 | Rat | Binding | pKi | None | - | 6.80 | -5 | 3 | Unclassified | Guide to Pharmacology | 368.2 | 12 | 4 | 5 | 2.22 | C[C@@H](O)CCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O | https://pubmed.ncbi.nlm.nih.gov/9537820 | |
AH13205 | 317 | None | 0 | Human | Binding | pKi | None | - | 6.00 | -12 | 3 | Unclassified | Guide to Pharmacology | 388.3 | 13 | 2 | 3 | 5.79 | CCCCCC(O)c1ccc(C2CCC(=O)C2CCCCCCC(=O)O)cc1 | https://pubmed.ncbi.nlm.nih.gov/10462542 | |
AH13205 | 317 | None | 0 | Mouse | Binding | pKi | None | - | 6.60 | -3 | 3 | Unclassified | Guide to Pharmacology | 388.3 | 13 | 2 | 3 | 5.79 | CCCCCC(O)c1ccc(C2CCC(=O)C2CCCCCCC(=O)O)cc1 | https://pubmed.ncbi.nlm.nih.gov/9313928 | |
AH13205 | 317 | 3H-PGE2 | 0 | Mouse | Binding | pKi | = | 240.00 | 6.62 | -3 | 3 | - | PDSP KiDatabase | 388.3 | 13 | 2 | 3 | 5.79 | CCCCCC(O)c1ccc(C2CCC(=O)C2CCCCCCC(=O)O)cc1 | - | |
AH6809 | 320 | None | 49 | Human | Binding | pKi | None | - | 5.90 | -3 | 10 | Unclassified | Guide to Pharmacology | 298.1 | 3 | 1 | 4 | 3.43 | CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 | https://pubmed.ncbi.nlm.nih.gov/10634944 | |
AH6809 | 320 | None | 49 | Human | Binding | Ki | = | 1150.00 | 5.94 | -3 | 10 | Inhibition of EP2 receptor (unknown origin) by competitive binding assay | ChEMBL | 298.1 | 3 | 1 | 4 | 3.43 | CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 | https://dx.doi.org/10.1021/jm401431x | |
AH6809 | 320 | None | 49 | Rat | Binding | pKi | None | - | 6.30 | -1 | 10 | Unclassified | Guide to Pharmacology | 298.1 | 3 | 1 | 4 | 3.43 | CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 | https://pubmed.ncbi.nlm.nih.gov/9537820 | |
AH6809 | 320 | None | 49 | Mouse | Binding | pKi | None | - | 6.50 | 1 | 10 | Unclassified | Guide to Pharmacology | 298.1 | 3 | 1 | 4 | 3.43 | CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 | https://pubmed.ncbi.nlm.nih.gov/9313928 | |
AH6809 | 320 | 3H-PGE2 | 49 | Mouse | Binding | pKi | = | 350.00 | 6.46 | 1 | 10 | - | PDSP KiDatabase | 298.1 | 3 | 1 | 4 | 3.43 | CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 | - | |
BUTAPROST | 97856 | None | 23 | Human | Binding | Ki | = | 110.00 | 6.96 | -4 | 9 | Binding affinity at human prostaglandin EP2 receptor | ChEMBL | 408.3 | 13 | 2 | 5 | 4.34 | CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 | https://dx.doi.org/10.1016/j.bmcl.2007.09.074 | |
BUTAPROST | 97856 | None | 23 | Human | Binding | Ki | = | 2400.00 | 5.62 | -4 | 9 | Binding affinity to EP2 receptor (unknown origin) by competitive binding assay | ChEMBL | 408.3 | 13 | 2 | 5 | 4.34 | CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 | https://dx.doi.org/10.1021/jm401431x | |
BUTAPROST | 97856 | None | 23 | Human | Binding | EC50 | = | 33.00 | 7.48 | -4 | 9 | Agonist activity at EP2 receptor (unknown origin) by functional assay | ChEMBL | 408.3 | 13 | 2 | 5 | 4.34 | CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 | https://dx.doi.org/10.1021/jm401431x | |
BUTAPROST | 97856 | None | 23 | Human | Binding | Ki | = | 110.00 | 6.96 | -4 | 9 | Displacement of [3H]PGE2 from human EP2 receptor | ChEMBL | 408.3 | 13 | 2 | 5 | 4.34 | CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 | https://dx.doi.org/10.1016/j.bmcl.2007.11.020 | |
BUTAPROST | 97856 | 3H-PGE2 | 23 | Mouse | Binding | pKi | = | 110.00 | 6.96 | 4 | 9 | - | PDSP KiDatabase | 408.3 | 13 | 2 | 5 | 4.34 | CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 | - |
Showing 1 to 20 of 793 entries
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
AH6809 | 320 | None | 49 | Human | Functional | Ki | = | 1150.00 | 5.94 | - | 10 | Antagonist activity at EP2 receptor (unknown origin) by functional cAMP assay | ChEMBL | 298.1 | 3 | 1 | 4 | 3.43 | CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 | https://dx.doi.org/10.1021/jm401431x | |
CHEMBL148449 | 40709 | None | 0 | Human | Functional | Kd | = | 251.19 | 6.60 | - | 1 | Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM | ChEMBL | 489.1 | 5 | 2 | 6 | 3.79 | O=C(CCS(=O)(=O)Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21 | https://dx.doi.org/10.1016/0960-894X(94)80027-8 | |
CHEMBL165010 | 57243 | None | 0 | Human | Functional | Ki | = | 43000.00 | 4.37 | - | 4 | Antagonistic activity at Prostanoid EP2 receptor in human was determined | ChEMBL | 284.1 | 5 | 1 | 2 | 4.10 | CSc1ccc(Cc2ccccc2/C=C/C(=O)O)cc1 | https://dx.doi.org/10.1016/s0960-894x(01)00056-7 | |
CHEMBL166351 | 57560 | None | 0 | Human | Functional | Ki | = | 13000.00 | 4.89 | - | 8 | Antagonistic activity at Prostanoid EP2 receptor in human was determined | ChEMBL | 306.0 | 4 | 1 | 1 | 4.68 | O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1 | https://dx.doi.org/10.1016/s0960-894x(01)00056-7 | |
CHEMBL1722929 | 59715 | None | 17 | Human | Functional | EC50 | = | 284.00 | 6.55 | -3 | 3 | Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay | ChEMBL | 388.3 | 13 | 2 | 3 | 5.79 | CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1 | - | |
CHEMBL1933722 | 69493 | None | 0 | Rat | Functional | EC50 | = | 90.00 | 7.05 | -112 | 5 | Agonist activity at rat EP2 receptor | ChEMBL | 432.1 | 9 | 2 | 6 | 3.39 | Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1 | https://dx.doi.org/10.1016/j.bmc.2012.02.018 | |
CHEMBL1933722 | 69493 | None | 0 | Rat | Functional | EC50 | = | 90.00 | 7.05 | -112 | 5 | Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay | ChEMBL | 432.1 | 9 | 2 | 6 | 3.39 | Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1 | https://dx.doi.org/10.1016/j.bmc.2012.04.008 | |
CHEMBL1933725 | 69496 | None | 0 | Human | Functional | EC50 | = | 5.60 | 8.25 | -11 | 6 | Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method | ChEMBL | 418.1 | 9 | 2 | 6 | 3.08 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1 | https://dx.doi.org/10.1021/acsmedchemlett.5b00455 | |
CHEMBL1957435 | 71330 | None | 0 | Rat | Functional | EC50 | = | 1800.00 | 5.75 | -223 | 6 | Agonist activity at rat EP2 receptor | ChEMBL | 494.1 | 10 | 2 | 6 | 4.75 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1 | https://dx.doi.org/10.1016/j.bmc.2012.02.018 | |
CHEMBL1957435 | 71330 | None | 0 | Rat | Functional | EC50 | = | 1800.00 | 5.75 | -223 | 6 | Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay | ChEMBL | 494.1 | 10 | 2 | 6 | 4.75 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1 | https://dx.doi.org/10.1016/j.bmc.2012.04.008 | |
CHEMBL1957436 | 71331 | None | 0 | Rat | Functional | EC50 | = | 260.00 | 6.58 | -9 | 5 | Agonist activity at rat EP2 receptor | ChEMBL | 528.1 | 10 | 2 | 6 | 5.41 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1 | https://dx.doi.org/10.1016/j.bmc.2012.02.018 | |
CHEMBL1957436 | 71331 | None | 0 | Rat | Functional | EC50 | = | 260.00 | 6.58 | -9 | 5 | Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay | ChEMBL | 528.1 | 10 | 2 | 6 | 5.41 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1 | https://dx.doi.org/10.1016/j.bmc.2012.04.008 | |
CHEMBL2036318 | 75190 | None | 0 | Rat | Functional | EC50 | = | 380.00 | 6.42 | -25 | 5 | Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay | ChEMBL | 508.1 | 10 | 2 | 6 | 5.06 | Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1 | https://dx.doi.org/10.1016/j.bmc.2012.04.008 | |
CHEMBL2036319 | 75191 | None | 0 | Rat | Functional | EC50 | = | 4600.00 | 5.34 | -301 | 5 | Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay | ChEMBL | 524.1 | 11 | 2 | 7 | 4.76 | COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1 | https://dx.doi.org/10.1016/j.bmc.2012.04.008 | |
CHEMBL2036321 | 75193 | None | 0 | Rat | Functional | EC50 | = | 1400.00 | 5.85 | -67 | 5 | Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay | ChEMBL | 522.2 | 10 | 2 | 6 | 5.37 | Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C | https://dx.doi.org/10.1016/j.bmc.2012.04.008 | |
CHEMBL2036322 | 75194 | None | 0 | Rat | Functional | EC50 | = | 1500.00 | 5.82 | -288 | 6 | Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay | ChEMBL | 534.1 | 10 | 2 | 7 | 5.50 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1 | https://dx.doi.org/10.1016/j.bmc.2012.04.008 | |
CHEMBL2036323 | 75195 | None | 0 | Rat | Functional | EC50 | = | 1600.00 | 5.80 | -724 | 4 | Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay | ChEMBL | 535.1 | 10 | 2 | 8 | 4.89 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1 | https://dx.doi.org/10.1016/j.bmc.2012.04.008 | |
CHEMBL2036324 | 75196 | None | 0 | Rat | Functional | EC50 | = | 2700.00 | 5.57 | -208 | 5 | Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay | ChEMBL | 551.1 | 10 | 2 | 8 | 5.36 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1 | https://dx.doi.org/10.1016/j.bmc.2012.04.008 | |
CHEMBL2037289 | 75313 | None | 0 | Rat | Functional | EC50 | = | 3200.00 | 5.50 | -1995 | 5 | Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay | ChEMBL | 549.1 | 10 | 2 | 8 | 5.20 | Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1 | https://dx.doi.org/10.1016/j.bmc.2012.04.008 | |
CHEMBL2037290 | 75314 | None | 0 | Rat | Functional | EC50 | = | 8500.00 | 5.07 | -301 | 5 | Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay | ChEMBL | 549.1 | 10 | 2 | 8 | 5.20 | Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12 | https://dx.doi.org/10.1016/j.bmc.2012.04.008 |
Showing 1 to 20 of 418 entries