Ligand source activities (1 row/activity)



Get vendors


Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type

 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
10210629 8762 None 0 Human Functional pIC50 = 9.9 9.9 2 4
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL109644 8762 None 0 Human Functional pIC50 = 9.9 9.9 2 4
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
9870830 206712 None 38 Human Functional pIC50 = 9.5 9.5 -1 5
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm00008a002
CHEMBL8981 206712 None 38 Human Functional pIC50 = 9.5 9.5 -1 5
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm00008a002
23670447 3027 None 2 Human Functional pIC50 = 9.5 9.5 1 4
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm00008a002
999 3027 None 2 Human Functional pIC50 = 9.5 9.5 1 4
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm00008a002
CHEMBL1204799 3027 None 2 Human Functional pIC50 = 9.5 9.5 1 4
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm00008a002
CHEMBL25438 3027 None 2 Human Functional pIC50 = 9.5 9.5 1 4
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm00008a002
10187997 109970 None 0 Human Functional pIC50 = 9.4 9.4 1 4
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL323464 109970 None 0 Human Functional pIC50 = 9.4 9.4 1 4
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
9916235 9351 None 1 Human Functional pIC50 = 9.3 9.3 1 4
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL111277 9351 None 1 Human Functional pIC50 = 9.3 9.3 1 4
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
10603409 110602 None 0 Human Functional pIC50 = 9.3 9.3 1 4
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
CHEMBL325581 110602 None 0 Human Functional pIC50 = 9.3 9.3 1 4
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
443289 710 None 47 Human Functional pIC50 = 9.2 9.2 1 4
Antagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric methodAntagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric method
ChEMBL None None None None 10.1016/j.ejmech.2016.06.006
997 710 None 47 Human Functional pIC50 = 9.2 9.2 1 4
Antagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric methodAntagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric method
ChEMBL None None None None 10.1016/j.ejmech.2016.06.006
CHEMBL314691 710 None 47 Human Functional pIC50 = 9.2 9.2 1 4
Antagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric methodAntagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric method
ChEMBL None None None None 10.1016/j.ejmech.2016.06.006
DB12054 710 None 47 Human Functional pIC50 = 9.2 9.2 1 4
Antagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric methodAntagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric method
ChEMBL None None None None 10.1016/j.ejmech.2016.06.006
CHEMBL3980643 212512 None 0 Human Functional pIC50 = 9.2 9.2 -6 2
Agonist activity at ETA receptor in human SKNMC cells assessed as induction of Ca2+ mobilization by fluorimetric methodAgonist activity at ETA receptor in human SKNMC cells assessed as induction of Ca2+ mobilization by fluorimetric method
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)[C@@H](C)CC 10.1016/j.ejmech.2016.06.006
10230737 112318 None 0 Human Functional pIC50 = 9.0 9.0 16 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL329251 112318 None 0 Human Functional pIC50 = 9.0 9.0 16 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3F)c3ccccc32)n1 10.1021/jm031115r
11318978 167901 None 0 Human Functional pIC50 = 8.9 8.9 7 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)n1 10.1021/jm031115r
CHEMBL431286 167901 None 0 Human Functional pIC50 = 8.9 8.9 7 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)n1 10.1021/jm031115r
10651488 163377 None 0 Human Functional pIC50 = 8.8 8.8 1 4
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
CHEMBL419367 163377 None 0 Human Functional pIC50 = 8.8 8.8 1 4
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
CHEMBL412706 213017 None 0 Pig Functional pIC50 = 8.8 8.8 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
9894443 112571 None 0 Human Functional pIC50 = 8.7 8.7 3 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 10.1021/jm031115r
CHEMBL330104 112571 None 0 Human Functional pIC50 = 8.7 8.7 3 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 10.1021/jm031115r
9955200 9330 None 0 Human Functional pIC50 = 8.7 8.7 53 3
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 446 6 1 7 3.8 COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL11115 9330 None 0 Human Functional pIC50 = 8.7 8.7 53 3
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 446 6 1 7 3.8 COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
70690542 76219 None 0 Human Functional pIC50 = 8 8.0 1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 532 9 1 6 6.6 CCCCc1nc2ccc(F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058375 76219 None 0 Human Functional pIC50 = 8 8.0 1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 532 9 1 6 6.6 CCCCc1nc2ccc(F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
70696781 76220 None 0 Human Functional pIC50 = 8 8.0 1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 582 9 1 6 7.5 CCCCc1nc2ccc(C(F)(F)F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058376 76220 None 0 Human Functional pIC50 = 8 8.0 1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 582 9 1 6 7.5 CCCCc1nc2ccc(C(F)(F)F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
11342089 107206 None 0 Human Functional pIC50 = 8.0 8.0 9 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 568 9 2 8 4.0 COc1ccc(CN2C(=O)CN[C@](c3cccc(OC)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL316629 107206 None 0 Human Functional pIC50 = 8.0 8.0 9 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 568 9 2 8 4.0 COc1ccc(CN2C(=O)CN[C@](c3cccc(OC)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
10230703 207857 None 0 Human Functional pIC50 = 8.0 8.0 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 542 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3Cl)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96472 207857 None 0 Human Functional pIC50 = 8.0 8.0 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 542 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3Cl)c3ccccc32)n1 10.1021/jm031115r
9957883 98655 None 0 Human Functional pIC50 = 7 7.0 25 2
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 507 7 1 9 5.0 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
CHEMBL27732 98655 None 0 Human Functional pIC50 = 7 7.0 25 2
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 507 7 1 9 5.0 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
44213651 4296 None 0 Human Functional pIC50 = 5 5.0 - 1
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 343 3 1 4 4.2 OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100795 4296 None 0 Human Functional pIC50 = 5 5.0 - 1
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 343 3 1 4 4.2 OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
11455999 207827 None 0 Human Functional pIC50 = 7 7.0 31 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 580 7 2 4 6.6 O=C(O)[C@@H](Oc1cccc(Cl)c1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 10.1021/jm031115r
CHEMBL96325 207827 None 0 Human Functional pIC50 = 7 7.0 31 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 580 7 2 4 6.6 O=C(O)[C@@H](Oc1cccc(Cl)c1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 10.1021/jm031115r
11490160 207499 None 0 Human Functional pIC50 = 7.0 7.0 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 584 8 2 6 5.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(-c4ccccc4)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL94446 207499 None 0 Human Functional pIC50 = 7.0 7.0 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 584 8 2 6 5.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(-c4ccccc4)cc3)c3ccccc32)n1 10.1021/jm031115r
11273181 207864 None 0 Human Functional pIC50 = 7.0 7.0 -4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C(F)(F)F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96506 207864 None 0 Human Functional pIC50 = 7.0 7.0 -4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C(F)(F)F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL386778 212388 None 0 Pig Functional pIC50 = 8.0 8.0 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL405337 212555 None 0 Pig Functional pIC50 = 8.0 8.0 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL405916 212583 None 0 Pig Functional pIC50 = 8.0 8.0 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL409180 212748 None 0 Pig Functional pIC50 = 8.0 8.0 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
6450144 122559 None 8 Rat Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at endothelin A receptor in rat A7r5 cells assessed as inhibition of ET-1-induced increase in cytosolic free Ca2+ level treated 1 min prior to ET-1 addition by fura-2 dye-based spectrofluorometric analysisAntagonist activity at endothelin A receptor in rat A7r5 cells assessed as inhibition of ET-1-induced increase in cytosolic free Ca2+ level treated 1 min prior to ET-1 addition by fura-2 dye-based spectrofluorometric analysis
ChEMBL 632 5 3 6 8.1 CC1(C)CC[C@]2(C(=O)O)CC[C@]3(COC(=O)/C=C/c4ccc(O)c(O)c4)C(=CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 10.1016/j.bmc.2015.06.055
CHEMBL3601500 122559 None 8 Rat Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at endothelin A receptor in rat A7r5 cells assessed as inhibition of ET-1-induced increase in cytosolic free Ca2+ level treated 1 min prior to ET-1 addition by fura-2 dye-based spectrofluorometric analysisAntagonist activity at endothelin A receptor in rat A7r5 cells assessed as inhibition of ET-1-induced increase in cytosolic free Ca2+ level treated 1 min prior to ET-1 addition by fura-2 dye-based spectrofluorometric analysis
ChEMBL 632 5 3 6 8.1 CC1(C)CC[C@]2(C(=O)O)CC[C@]3(COC(=O)/C=C/c4ccc(O)c(O)c4)C(=CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 10.1016/j.bmc.2015.06.055
70684240 76221 None 0 Human Functional pIC50 = 8.0 8.0 1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 559 10 1 8 6.4 CCCCc1nc2ccc([N+](=O)[O-])cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058377 76221 None 0 Human Functional pIC50 = 8.0 8.0 1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 559 10 1 8 6.4 CCCCc1nc2ccc([N+](=O)[O-])cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
11421972 207843 None 0 Human Functional pIC50 = 8.0 8.0 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 592 8 2 7 4.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(OC(F)(F)F)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96422 207843 None 0 Human Functional pIC50 = 8.0 8.0 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 592 8 2 7 4.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(OC(F)(F)F)c3)c3ccccc32)n1 10.1021/jm031115r
11342005 207547 None 0 Human Functional pIC50 = 7.9 7.9 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)c(F)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL94766 207547 None 0 Human Functional pIC50 = 7.9 7.9 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)c(F)c3)c3ccccc32)n1 10.1021/jm031115r
11744509 5428 None 0 Human Functional pIC50 = 7.0 7.0 5 2
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 450 5 1 6 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 10.1021/jm00008a002
CHEMBL10733 5428 None 0 Human Functional pIC50 = 7.0 7.0 5 2
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 450 5 1 6 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 10.1021/jm00008a002
122194935 124092 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assayAntagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assay
ChEMBL 619 11 2 8 6.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(S(F)(F)(F)(F)F)cc2)cc(-c2ncccn2)cc1OCCO 10.1021/acs.jmedchem.5b00258
CHEMBL3633040 124092 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assayAntagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assay
ChEMBL 619 11 2 8 6.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(S(F)(F)(F)(F)F)cc2)cc(-c2ncccn2)cc1OCCO 10.1021/acs.jmedchem.5b00258
11387205 111559 None 0 Human Functional pIC50 = 7.0 7.0 -1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 8 2 7 4.5 COc1ccc(CN2C(=O)CN[C@](C3CCCCC3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL328073 111559 None 0 Human Functional pIC50 = 7.0 7.0 -1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 8 2 7 4.5 COc1ccc(CN2C(=O)CN[C@](C3CCCCC3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL62302 215841 None 0 Pig Functional pIC50 = 7.9 7.9 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
10342643 5155 None 0 Human Functional pIC50 = 7.9 7.9 144 2
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm00008a002
CHEMBL10588 5155 None 0 Human Functional pIC50 = 7.9 7.9 144 2
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm00008a002
10342643 5155 None 0 Human Functional pIC50 = 7.9 7.9 144 2
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm00008a002
CHEMBL10588 5155 None 0 Human Functional pIC50 = 7.9 7.9 144 2
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm00008a002
10224745 112688 None 0 Human Functional pIC50 = 7.9 7.9 15 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 432 5 2 6 2.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1021/jm031115r
CHEMBL330425 112688 None 0 Human Functional pIC50 = 7.9 7.9 15 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 432 5 2 6 2.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1021/jm031115r
9865706 98132 None 0 Human Functional pIC50 = 5.9 5.9 1 2
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 400 4 1 5 4.1 Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
CHEMBL273613 98132 None 0 Human Functional pIC50 = 5.9 5.9 1 2
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 400 4 1 5 4.1 Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
10452089 4563 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 375 3 0 5 4.1 COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 10.1016/S0960-894X(96)00551-3
CHEMBL102494 4563 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 375 3 0 5 4.1 COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 10.1016/S0960-894X(96)00551-3
11432855 207852 None 0 Human Functional pIC50 = 6.9 6.9 28 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 552 8 3 7 3.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(=O)O)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96463 207852 None 0 Human Functional pIC50 = 6.9 6.9 28 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 552 8 3 7 3.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(=O)O)cc3)c3ccccc32)n1 10.1021/jm031115r
11318559 207800 None 0 Human Functional pIC50 = 6.9 6.9 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 531 8 2 8 2.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN3CCOCC3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96193 207800 None 0 Human Functional pIC50 = 6.9 6.9 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 531 8 2 8 2.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN3CCOCC3)c3ccccc32)n1 10.1021/jm031115r
11238540 207523 None 0 Human Functional pIC50 = 6.9 6.9 11 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 8 2 5 5.9 COc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL94602 207523 None 0 Human Functional pIC50 = 6.9 6.9 11 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 8 2 5 5.9 COc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
10140418 106199 None 0 Human Functional pIC50 = 7.9 7.9 43 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 476 7 3 7 1.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC(=O)O)c3ccccc32)n1 10.1021/jm031115r
CHEMBL313867 106199 None 0 Human Functional pIC50 = 7.9 7.9 43 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 476 7 3 7 1.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC(=O)O)c3ccccc32)n1 10.1021/jm031115r
11308052 112663 None 0 Human Functional pIC50 = 7.9 7.9 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 618 10 2 6 5.8 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 10.1021/jm031115r
CHEMBL330354 112663 None 0 Human Functional pIC50 = 7.9 7.9 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 618 10 2 6 5.8 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 10.1021/jm031115r
122194934 124091 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assayAntagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assay
ChEMBL 561 10 2 8 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(F)(F)F)cc2)cc(-c2ncccn2)cc1OCCO 10.1021/acs.jmedchem.5b00258
CHEMBL3633039 124091 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assayAntagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assay
ChEMBL 561 10 2 8 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(F)(F)F)cc2)cc(-c2ncccn2)cc1OCCO 10.1021/acs.jmedchem.5b00258
CHEMBL97470 215923 None 0 Human Functional pIC50 = 6.9 6.9 -1 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL3143473 211332 None 0 Human Functional pIC50 = 5.9 5.9 -1071 2
Antagonistic activity against endothelin A (ETA) receptor using human neuroblastoma cell line.Antagonistic activity against endothelin A (ETA) receptor using human neuroblastoma cell line.
ChEMBL None None None CCCC[C@@H](NC(=O)[C@@H](Cc1cn(COC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00084-7
CHEMBL3305972 211332 None 0 Human Functional pIC50 = 5.9 5.9 -1071 2
Antagonistic activity against endothelin A (ETA) receptor using human neuroblastoma cell line.Antagonistic activity against endothelin A (ETA) receptor using human neuroblastoma cell line.
ChEMBL None None None CCCC[C@@H](NC(=O)[C@@H](Cc1cn(COC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00084-7
345351 9357 None 4 Human Functional pIC50 = 5.9 5.9 24 3
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 386 4 1 5 3.8 O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL11131 9357 None 4 Human Functional pIC50 = 5.9 5.9 24 3
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 386 4 1 5 3.8 O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
44332623 4764 None 1 Human Functional pIC50 = 4.9 4.9 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 320 3 1 4 2.9 Cc1cc(C(C(N)=O)c2ccc3c(c2)OCO3)c2ccccc2n1 10.1016/S0960-894X(96)00551-3
CHEMBL103886 4764 None 1 Human Functional pIC50 = 4.9 4.9 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 320 3 1 4 2.9 Cc1cc(C(C(N)=O)c2ccc3c(c2)OCO3)c2ccccc2n1 10.1016/S0960-894X(96)00551-3
CHEMBL405599 212566 None 0 Human Functional pIC50 = 7.9 7.9 1 3
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
11744509 5428 None 0 Human Functional pIC50 = 6.9 6.9 5 2
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 450 5 1 6 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 10.1021/jm00008a002
CHEMBL10733 5428 None 0 Human Functional pIC50 = 6.9 6.9 5 2
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 450 5 1 6 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 10.1021/jm00008a002
11386977 207545 None 0 Human Functional pIC50 = 6.8 6.8 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 528 8 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCC3CCCCC3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL94752 207545 None 0 Human Functional pIC50 = 6.8 6.8 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 528 8 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCC3CCCCC3)c3ccccc32)n1 10.1021/jm031115r
11226767 207524 None 0 Human Functional pIC50 = 6.8 6.8 6 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 4 6.2 Cc1ccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL94606 207524 None 0 Human Functional pIC50 = 6.8 6.8 6 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 4 6.2 Cc1ccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)cc1 10.1021/jm031115r
11452452 207200 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 404 5 2 6 1.8 CN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2ncccn2)C(=O)O)c2ccccc21 10.1021/jm031115r
CHEMBL92612 207200 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 404 5 2 6 1.8 CN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2ncccn2)C(=O)O)c2ccccc21 10.1021/jm031115r
CHEMBL284250 210858 None 0 Human Functional pIC50 = 7.8 7.8 -19 4
Functional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptorFunctional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptor
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1016/0960-894X(95)00237-N
11331242 107418 None 0 Human Functional pIC50 = 7.8 7.8 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 652 8 2 6 7.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 10.1021/jm031115r
CHEMBL318086 107418 None 0 Human Functional pIC50 = 7.8 7.8 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 652 8 2 6 7.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 10.1021/jm031115r
CHEMBL265116 210633 None 0 Human Functional pIC50 = 6.8 6.8 -3 3
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
CHEMBL4533479 213984 None 1 Human Functional pIC50 = 5.8 5.8 -1 2
Eurofins cellular functional assay - Antagonist (EDNRA)Eurofins cellular functional assay - Antagonist (EDNRA)
ChEMBL None None None CCCOc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 10.6019/CHEMBL4507261
10166981 207086 None 0 Human Functional pIC50 = 7.8 7.8 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(F)(F)F)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL91926 207086 None 0 Human Functional pIC50 = 7.8 7.8 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(F)(F)F)cc3)c3ccccc32)n1 10.1021/jm031115r
11410074 207788 None 0 Human Functional pIC50 = 7.8 7.8 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 536 9 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCc3ccccc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96114 207788 None 0 Human Functional pIC50 = 7.8 7.8 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 536 9 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCc3ccccc3)c3ccccc32)n1 10.1021/jm031115r
11365059 207793 None 0 Human Functional pIC50 = 7.8 7.8 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 564 7 2 6 5.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(C)(C)C)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96154 207793 None 0 Human Functional pIC50 = 7.8 7.8 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 564 7 2 6 5.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(C)(C)C)cc3)c3ccccc32)n1 10.1021/jm031115r
10347783 207832 None 0 Human Functional pIC50 = 7.8 7.8 32 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 4 5.6 Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 10.1021/jm031115r
CHEMBL96347 207832 None 0 Human Functional pIC50 = 7.8 7.8 32 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 4 5.6 Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 10.1021/jm031115r
11753090 106201 None 0 Human Functional pIC50 = 7.8 7.8 7 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 542 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Cl)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL313870 106201 None 0 Human Functional pIC50 = 7.8 7.8 7 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 542 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Cl)cc3)c3ccccc32)n1 10.1021/jm031115r
10412464 9135 None 0 Human Functional pIC50 = 6.8 6.8 11 2
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 470 6 1 5 5.4 COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10996 9135 None 0 Human Functional pIC50 = 6.8 6.8 11 2
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 470 6 1 5 5.4 COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
44327656 141787 None 0 Human Functional pIC50 = 5.8 5.8 -1 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 977 25 9 8 4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(F)(F)F)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL386181 141787 None 0 Human Functional pIC50 = 5.8 5.8 -1 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 977 25 9 8 4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(F)(F)F)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
11330923 207820 None 0 Human Functional pIC50 = 7.7 7.7 -1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 606 10 2 6 6.3 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(C)cc(C)cc3C)c3ccccc32)c1 10.1021/jm031115r
CHEMBL96303 207820 None 0 Human Functional pIC50 = 7.7 7.7 -1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 606 10 2 6 6.3 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(C)cc(C)cc3C)c3ccccc32)c1 10.1021/jm031115r
11226740 207900 None 0 Human Functional pIC50 = 7.7 7.7 9 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 558 7 2 4 6.0 Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL96704 207900 None 0 Human Functional pIC50 = 7.7 7.7 9 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 558 7 2 4 6.0 Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL408574 212720 None 0 Pig Functional pIC50 = 7.7 7.7 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
10410546 9410 None 0 Human Functional pIC50 = 6.7 6.7 37 2
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 432 7 1 6 4.1 COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL11162 9410 None 0 Human Functional pIC50 = 6.7 6.7 37 2
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 432 7 1 6 4.1 COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL319537 211217 None 0 Human Functional pIC50 = 5.7 5.7 2 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL409808 212784 None 0 Pig Functional pIC50 = 8.7 8.7 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
10120430 207518 None 0 Human Functional pIC50 = 8.6 8.6 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)ccc(F)c3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL94580 207518 None 0 Human Functional pIC50 = 8.6 8.6 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)ccc(F)c3F)c3ccccc32)n1 10.1021/jm031115r
9890440 8252 None 0 Human Functional pIC50 = 8.6 8.6 301 2
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 10.1021/jm00008a002
CHEMBL10924 8252 None 0 Human Functional pIC50 = 8.6 8.6 301 2
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 10.1021/jm00008a002
10166543 112360 None 0 Human Functional pIC50 = 8.6 8.6 33 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL329477 112360 None 0 Human Functional pIC50 = 8.6 8.6 33 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
10282008 207079 None 0 Human Functional pIC50 = 8.6 8.6 12 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 592 8 2 7 4.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(OC(F)(F)F)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL91873 207079 None 0 Human Functional pIC50 = 8.6 8.6 12 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 592 8 2 7 4.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(OC(F)(F)F)cc3)c3ccccc32)n1 10.1021/jm031115r
11224973 107448 None 0 Human Functional pIC50 = 7.7 7.7 32 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 460 7 2 6 2.9 CCc1cc(CC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1021/jm031115r
CHEMBL318270 107448 None 0 Human Functional pIC50 = 7.7 7.7 32 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 460 7 2 6 2.9 CCc1cc(CC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1021/jm031115r
11169125 207557 None 0 Human Functional pIC50 = 7.7 7.7 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 574 7 2 4 6.5 Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL94802 207557 None 0 Human Functional pIC50 = 7.7 7.7 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 574 7 2 4 6.5 Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL263295 210563 None 0 Human Functional pIC50 = 6.7 6.7 -1 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
10024044 7837 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 402 6 1 5 4.1 COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10897 7837 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 402 6 1 5 4.1 COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
44332577 4704 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 341 3 0 4 4.4 O=CC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL103484 4704 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 341 3 0 4 4.4 O=CC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL2373086 210370 None 0 Pig Functional pIC50 = 7.7 7.7 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)[C@@H](C)CC)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
3951 391 None 86 Human Functional pIC50 = 7.7 7.7 47 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm031115r
4337 391 None 86 Human Functional pIC50 = 7.7 7.7 47 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm031115r
6918493 391 None 86 Human Functional pIC50 = 7.7 7.7 47 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm031115r
CHEMBL1111 391 None 86 Human Functional pIC50 = 7.7 7.7 47 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm031115r
DB06403 391 None 86 Human Functional pIC50 = 7.7 7.7 47 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm031115r
CHEMBL317099 211196 None 0 Human Functional pIC50 = 5.7 5.7 -69 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL96822 215918 None 0 Human Functional pIC50 = 5.7 5.7 -1 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NS(C)(=O)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
11786120 169166 None 0 Human Functional pIC50 = 6.7 6.7 17 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 546 7 2 4 5.9 O=C(O)[C@@H](Oc1ccccc1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 10.1021/jm031115r
CHEMBL440507 169166 None 0 Human Functional pIC50 = 6.7 6.7 17 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 546 7 2 4 5.9 O=C(O)[C@@H](Oc1ccccc1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 10.1021/jm031115r
70692693 76213 None 0 Human Functional pIC50 = 7.7 7.7 -1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 500 8 1 6 6.1 CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058369 76213 None 0 Human Functional pIC50 = 7.7 7.7 -1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 500 8 1 6 6.1 CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
10385531 112680 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 387 4 0 6 4.4 COC(=O)C(Oc1c2ccccc2nc2ccccc12)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00551-3
CHEMBL330414 112680 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 387 4 0 6 4.4 COC(=O)C(Oc1c2ccccc2nc2ccccc12)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00551-3
10024044 7837 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 402 6 1 5 4.1 COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10897 7837 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 402 6 1 5 4.1 COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
10070783 97054 None 0 Human Functional pIC50 = 5.7 5.7 3 3
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL267094 97054 None 0 Human Functional pIC50 = 5.7 5.7 3 3
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
11387315 207432 None 0 Human Functional pIC50 = 6.7 6.7 -1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 552 8 2 7 4.3 COc1ccc(CN2C(=O)CN[C@](c3ccc(C)cc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL94091 207432 None 0 Human Functional pIC50 = 6.7 6.7 -1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 552 8 2 7 4.3 COc1ccc(CN2C(=O)CN[C@](c3ccc(C)cc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11408654 207934 None 0 Human Functional pIC50 = 7.6 7.6 19 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 464 7 2 8 1.8 COc1cc(OC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96906 207934 None 0 Human Functional pIC50 = 7.6 7.6 19 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 464 7 2 8 1.8 COc1cc(OC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1021/jm031115r
11409474 207558 None 0 Human Functional pIC50 = 7.6 7.6 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 502 10 2 6 4.4 CCCCCCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 10.1021/jm031115r
CHEMBL94810 207558 None 0 Human Functional pIC50 = 7.6 7.6 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 502 10 2 6 4.4 CCCCCCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 10.1021/jm031115r
44327659 109820 None 0 Human Functional pIC50 = 6.6 6.6 -1 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 8 4.6 CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 10.1021/jm00015a003
CHEMBL323331 109820 None 0 Human Functional pIC50 = 6.6 6.6 -1 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 8 4.6 CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 10.1021/jm00015a003
CHEMBL263186 210560 None 0 Pig Functional pIC50 = 7.6 7.6 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
9896251 98771 None 0 Human Functional pIC50 = 7.6 7.6 -1 3
Antagonist activity at endothelin receptor subtype AAntagonist activity at endothelin receptor subtype A
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/j.bmc.2012.06.011
CHEMBL278176 98771 None 0 Human Functional pIC50 = 7.6 7.6 -1 3
Antagonist activity at endothelin receptor subtype AAntagonist activity at endothelin receptor subtype A
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/j.bmc.2012.06.011
11467573 107238 None 0 Human Functional pIC50 = 7.6 7.6 9 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 606 8 2 7 5.0 COc1ccc(CN2C(=O)CN[C@](c3cccc(C(F)(F)F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL316851 107238 None 0 Human Functional pIC50 = 7.6 7.6 9 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 606 8 2 7 5.0 COc1ccc(CN2C(=O)CN[C@](c3cccc(C(F)(F)F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11238500 207822 None 0 Human Functional pIC50 = 7.6 7.6 3 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 572 8 2 7 4.7 COc1ccc(CN2C(=O)CN[C@](c3cccc(Cl)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL96313 207822 None 0 Human Functional pIC50 = 7.6 7.6 3 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 572 8 2 7 4.7 COc1ccc(CN2C(=O)CN[C@](c3cccc(Cl)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11753582 207586 None 0 Human Functional pIC50 = 7.6 7.6 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 586 7 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Br)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL94962 207586 None 0 Human Functional pIC50 = 7.6 7.6 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 586 7 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Br)cc3)c3ccccc32)n1 10.1021/jm031115r
11397857 207789 None 0 Human Functional pIC50 = 6.6 6.6 6 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 496 7 2 6 3.7 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccc(Cl)cc32)c1 10.1021/jm031115r
CHEMBL96125 207789 None 0 Human Functional pIC50 = 6.6 6.6 6 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 496 7 2 6 3.7 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccc(Cl)cc32)c1 10.1021/jm031115r
11489946 207345 None 0 Human Functional pIC50 = 6.6 6.6 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 566 8 2 7 4.6 COc1ccc(CN2C(=O)CN[C@](c3cc(C)cc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL93612 207345 None 0 Human Functional pIC50 = 6.6 6.6 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 566 8 2 7 4.6 COc1ccc(CN2C(=O)CN[C@](c3cc(C)cc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL433406 213638 None 0 Human Functional pIC50 = 6.6 6.6 -9 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)NC)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44332803 4705 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 335 3 0 5 3.6 COC(=O)C(c1ccc2c(c1)OCO2)c1cc(C)nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL103497 4705 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 335 3 0 5 3.6 COC(=O)C(c1ccc2c(c1)OCO2)c1cc(C)nc2ccccc12 10.1016/S0960-894X(96)00551-3
9820754 108560 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 371 3 0 5 4.4 COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL320236 108560 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 371 3 0 5 4.4 COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
11410410 207548 None 0 Human Functional pIC50 = 7.5 7.5 25 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 4 6.2 Cc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL94769 207548 None 0 Human Functional pIC50 = 7.5 7.5 25 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 4 6.2 Cc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL319660 211218 None 0 Human Functional pIC50 = 7.5 7.5 2 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
CHEMBL410694 212832 None 0 Pig Functional pIC50 = 8.5 8.5 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL411965 212964 None 0 Pig Functional pIC50 = 8.5 8.5 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
11387934 107175 None 0 Human Functional pIC50 = 8.5 8.5 28 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 614 9 2 7 5.7 COc1ccc(CN2C(=O)CN[C@](c3cccc(-c4ccccc4)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL316453 107175 None 0 Human Functional pIC50 = 8.5 8.5 28 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 614 9 2 7 5.7 COc1ccc(CN2C(=O)CN[C@](c3cccc(-c4ccccc4)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11353580 207936 None 0 Human Functional pIC50 = 8.5 8.5 21 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 566 9 2 7 4.6 CCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 10.1021/jm031115r
CHEMBL96932 207936 None 0 Human Functional pIC50 = 8.5 8.5 21 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 566 9 2 7 4.6 CCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 10.1021/jm031115r
10303258 161873 None 0 Human Functional pIC50 = 8.5 8.5 3 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 564 10 2 6 5.3 CCCCc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL415010 161873 None 0 Human Functional pIC50 = 8.5 8.5 3 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 564 10 2 6 5.3 CCCCc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11168474 207903 None 0 Human Functional pIC50 = 8.5 8.5 9 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 526 7 2 6 4.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96723 207903 None 0 Human Functional pIC50 = 8.5 8.5 9 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 526 7 2 6 4.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3F)c3ccccc32)n1 10.1021/jm031115r
11421392 207383 None 0 Human Functional pIC50 = 8.4 8.4 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL93820 207383 None 0 Human Functional pIC50 = 8.4 8.4 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3F)c3ccccc32)n1 10.1021/jm031115r
11489318 207797 None 0 Human Functional pIC50 = 8.4 8.4 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 8 2 6 4.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCc3ccccc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96171 207797 None 0 Human Functional pIC50 = 8.4 8.4 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 8 2 6 4.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCc3ccccc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL94983 215914 None 0 Human Functional pIC50 = 7.5 7.5 7 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
11398818 167929 None 0 Human Functional pIC50 = 7.5 7.5 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 556 8 2 7 4.2 COc1ccc(CN2C(=O)CN[C@](c3ccccc3F)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL431460 167929 None 0 Human Functional pIC50 = 7.5 7.5 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 556 8 2 7 4.2 COc1ccc(CN2C(=O)CN[C@](c3ccccc3F)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11156692 167874 None 0 Human Functional pIC50 = 7.5 7.5 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 7 2 6 4.3 Cc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL431087 167874 None 0 Human Functional pIC50 = 7.5 7.5 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 7 2 6 4.3 Cc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
10412464 9135 None 0 Human Functional pIC50 = 6.5 6.5 11 2
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 470 6 1 5 5.4 COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10996 9135 None 0 Human Functional pIC50 = 6.5 6.5 11 2
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 470 6 1 5 5.4 COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
10410546 9410 None 0 Human Functional pIC50 = 6.5 6.5 37 2
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 432 7 1 6 4.1 COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL11162 9410 None 0 Human Functional pIC50 = 6.5 6.5 37 2
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 432 7 1 6 4.1 COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
15289330 99800 None 0 Human Functional pIC50 = 7.5 7.5 18 2
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 493 8 1 8 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL285368 99800 None 0 Human Functional pIC50 = 7.5 7.5 18 2
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 493 8 1 8 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL97431 215922 None 0 Human Functional pIC50 = 6.5 6.5 2 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
18995989 100553 None 0 Human Functional pIC50 = 5.5 5.5 -2 2
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 583 9 1 9 6.6 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 10.1016/0960-894X(96)00232-6
CHEMBL29147 100553 None 0 Human Functional pIC50 = 5.5 5.5 -2 2
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 583 9 1 9 6.6 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 10.1016/0960-894X(96)00232-6
11307120 112402 None 0 Human Functional pIC50 = 6.5 6.5 -4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 532 11 2 7 4.5 CCCCC[C@]1([C@H](Oc2nc(C)cc(C)n2)C(=O)O)NCC(=O)N(Cc2ccc(OC)cc2)c2ccccc21 10.1021/jm031115r
CHEMBL329744 112402 None 0 Human Functional pIC50 = 6.5 6.5 -4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 532 11 2 7 4.5 CCCCC[C@]1([C@H](Oc2nc(C)cc(C)n2)C(=O)O)NCC(=O)N(Cc2ccc(OC)cc2)c2ccccc21 10.1021/jm031115r
1009 194 None 25 Human Functional pIC50 = 5.4 5.4 -1621 2
Eurofins cellular functional assay - Antagonist (EDNRA)Eurofins cellular functional assay - Antagonist (EDNRA)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.6019/CHEMBL4507261
5310991 194 None 25 Human Functional pIC50 = 5.4 5.4 -1621 2
Eurofins cellular functional assay - Antagonist (EDNRA)Eurofins cellular functional assay - Antagonist (EDNRA)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.6019/CHEMBL4507261
CHEMBL332794 194 None 25 Human Functional pIC50 = 5.4 5.4 -1621 2
Eurofins cellular functional assay - Antagonist (EDNRA)Eurofins cellular functional assay - Antagonist (EDNRA)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.6019/CHEMBL4507261
11362537 107519 None 0 Human Functional pIC50 = 6.4 6.4 24 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 434 6 2 7 1.8 COc1cnc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)nc1 10.1021/jm031115r
CHEMBL318683 107519 None 0 Human Functional pIC50 = 6.4 6.4 24 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 434 6 2 7 1.8 COc1cnc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)nc1 10.1021/jm031115r
11167889 207833 None 0 Human Functional pIC50 = 5.4 5.4 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 496 7 2 6 3.7 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(Cl)ccc32)c1 10.1021/jm031115r
CHEMBL96351 207833 None 0 Human Functional pIC50 = 5.4 5.4 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 496 7 2 6 3.7 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(Cl)ccc32)c1 10.1021/jm031115r
11752174 172723 None 0 Human Functional pIC50 = 6.4 6.4 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 489 8 2 7 2.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN(C)C)c3ccccc32)n1 10.1021/jm031115r
CHEMBL450628 172723 None 0 Human Functional pIC50 = 6.4 6.4 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 489 8 2 7 2.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN(C)C)c3ccccc32)n1 10.1021/jm031115r
70686381 76212 None 0 Human Functional pIC50 = 7.4 7.4 -1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 486 7 1 6 5.7 CCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058368 76212 None 0 Human Functional pIC50 = 7.4 7.4 -1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 486 7 1 6 5.7 CCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
11785180 111506 None 0 Human Functional pIC50 = 5.4 5.4 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 492 8 2 7 3.1 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)ccc32)c1 10.1021/jm031115r
CHEMBL327823 111506 None 0 Human Functional pIC50 = 5.4 5.4 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 492 8 2 7 3.1 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)ccc32)c1 10.1021/jm031115r
CHEMBL1790448 208886 None 0 Pig Functional pIC50 = 8.4 8.4 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)[C@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL293029 210886 None 0 Pig Functional pIC50 = 8.4 8.4 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
CHEMBL410869 212845 None 0 Pig Functional pIC50 = 8.4 8.4 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
10230546 107245 None 0 Human Functional pIC50 = 8.3 8.3 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 538 8 2 7 4.0 COc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL316878 107245 None 0 Human Functional pIC50 = 8.3 8.3 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 538 8 2 7 4.0 COc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
9807691 100062 None 0 Human Functional pIC50 = 8.3 8.3 134 2
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 553 10 1 10 5.3 COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
CHEMBL287169 100062 None 0 Human Functional pIC50 = 8.3 8.3 134 2
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 553 10 1 10 5.3 COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
44304492 96558 None 0 Human Functional pIC50 = 8.3 8.3 1 4
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL262993 96558 None 0 Human Functional pIC50 = 8.3 8.3 1 4
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10027018 98487 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 454 4 1 5 5.1 O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL275991 98487 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 454 4 1 5 5.1 O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL94907 215912 None 0 Human Functional pIC50 = 6.4 6.4 1 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
10070783 97054 None 0 Human Functional pIC50 = 6.4 6.4 3 3
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL267094 97054 None 0 Human Functional pIC50 = 6.4 6.4 3 3
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL2370255 209817 None 0 Human Functional pIC50 = 6.4 6.4 -13 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL433349 213635 None 0 Human Functional pIC50 = 6.4 6.4 -1 3
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL2370254 209816 None 0 Human Functional pIC50 = 5.4 5.4 2 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
11168401 112302 None 0 Human Functional pIC50 = 6.4 6.4 18 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 9 2 8 3.1 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)c(OC)cc32)c1 10.1021/jm031115r
CHEMBL329132 112302 None 0 Human Functional pIC50 = 6.4 6.4 18 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 9 2 8 3.1 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)c(OC)cc32)c1 10.1021/jm031115r
11156376 112664 None 0 Human Functional pIC50 = 7.3 7.3 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 504 9 3 7 2.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCC(=O)O)c3ccccc32)n1 10.1021/jm031115r
CHEMBL330359 112664 None 0 Human Functional pIC50 = 7.3 7.3 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 504 9 3 7 2.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCC(=O)O)c3ccccc32)n1 10.1021/jm031115r
CHEMBL318020 211207 None 0 Human Functional pIC50 = 6.4 6.4 8 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
11330927 207505 None 0 Human Functional pIC50 = 7.3 7.3 8 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 606 9 2 6 5.9 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL94488 207505 None 0 Human Functional pIC50 = 7.3 7.3 8 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 606 9 2 6 5.9 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
10385531 112680 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 387 4 0 6 4.4 COC(=O)C(Oc1c2ccccc2nc2ccccc12)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00551-3
CHEMBL330414 112680 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 387 4 0 6 4.4 COC(=O)C(Oc1c2ccccc2nc2ccccc12)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00551-3
9865706 98132 None 0 Human Functional pIC50 = 5.3 5.3 1 2
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 400 4 1 5 4.1 Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
CHEMBL273613 98132 None 0 Human Functional pIC50 = 5.3 5.3 1 2
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 400 4 1 5 4.1 Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
CHEMBL264330 210610 None 0 Pig Functional pIC50 = 8.3 8.3 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
CHEMBL386850 212395 None 0 Pig Functional pIC50 = 8.3 8.3 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
11318409 207453 None 0 Human Functional pIC50 = 8.3 8.3 3 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 7 2 6 4.3 Cc1cccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c1 10.1021/jm031115r
CHEMBL94212 207453 None 0 Human Functional pIC50 = 8.3 8.3 3 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 7 2 6 4.3 Cc1cccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c1 10.1021/jm031115r
10187261 111538 None 0 Human Functional pIC50 = 8.2 8.2 3 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 542 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Cl)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL327976 111538 None 0 Human Functional pIC50 = 8.2 8.2 3 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 542 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Cl)c3)c3ccccc32)n1 10.1021/jm031115r
11785813 106920 None 0 Human Functional pIC50 = 8.2 8.2 8 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 526 7 2 6 4.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL314755 106920 None 0 Human Functional pIC50 = 8.2 8.2 8 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 526 7 2 6 4.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL408616 212722 None 0 Pig Functional pIC50 = 7.3 7.3 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
9845562 4739 None 0 Human Functional pIC50 = 7.3 7.3 7 3
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 10.1021/jm00008a002
CHEMBL10374 4739 None 0 Human Functional pIC50 = 7.3 7.3 7 3
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 10.1021/jm00008a002
11742628 98233 None 0 Human Functional pIC50 = 7.3 7.3 25 3
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 416 5 1 6 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
CHEMBL274383 98233 None 0 Human Functional pIC50 = 7.3 7.3 25 3
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 416 5 1 6 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
9845562 4739 None 0 Human Functional pIC50 = 7.3 7.3 7 3
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 10.1021/jm00008a002
CHEMBL10374 4739 None 0 Human Functional pIC50 = 7.3 7.3 7 3
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 10.1021/jm00008a002
CHEMBL411797 212955 None 0 Human Functional pIC50 = 6.3 6.3 1 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10226239 207886 None 0 Human Functional pIC50 = 7.3 7.3 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 456 5 2 8 2.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(C)n3-c3ccccc32)n1 10.1021/jm031115r
CHEMBL96614 207886 None 0 Human Functional pIC50 = 7.3 7.3 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 456 5 2 8 2.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(C)n3-c3ccccc32)n1 10.1021/jm031115r
10027018 98487 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 454 4 1 5 5.1 O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL275991 98487 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 454 4 1 5 5.1 O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
44332578 4313 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 413 3 0 5 5.6 CC(C)(C)OC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100874 4313 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 413 3 0 5 5.6 CC(C)(C)OC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
122272 97095 None 31 Human Functional pIC50 = 6.2 6.2 -4 4
Antagonism of ET-1 induced increase in intracellular Ca+2 in vsm-A10 cellsAntagonism of ET-1 induced increase in intracellular Ca+2 in vsm-A10 cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00029a001
CHEMBL267458 97095 None 31 Human Functional pIC50 = 6.2 6.2 -4 4
Antagonism of ET-1 induced increase in intracellular Ca+2 in vsm-A10 cellsAntagonism of ET-1 induced increase in intracellular Ca+2 in vsm-A10 cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00029a001
10047521 8628 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 416 6 1 5 4.4 COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10951 8628 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 416 6 1 5 4.4 COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
11156301 78662 None 0 Human Functional pIC50 = 7.2 7.2 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 500 7 3 9 2.2 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(CC(=O)O)n3-c3ccccc32)n1 10.1021/jm031115r
CHEMBL2112377 78662 None 0 Human Functional pIC50 = 7.2 7.2 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 500 7 3 9 2.2 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(CC(=O)O)n3-c3ccccc32)n1 10.1021/jm031115r
9820754 108560 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Compound was tested for inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsCompound was tested for inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 371 3 0 5 4.4 COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL320236 108560 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Compound was tested for inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsCompound was tested for inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 371 3 0 5 4.4 COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
11203972 106875 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 8 2 5 5.9 COc1ccccc1O[C@H](C(=O)O)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 10.1021/jm031115r
CHEMBL314511 106875 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 8 2 5 5.9 COc1ccccc1O[C@H](C(=O)O)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 10.1021/jm031115r
CHEMBL2373085 210369 None 0 Pig Functional pIC50 = 8.2 8.2 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL433837 213643 None 0 Pig Functional pIC50 = 8.2 8.2 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL62641 215844 None 0 Pig Functional pIC50 = 8.2 8.2 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
10187313 107442 None 0 Human Functional pIC50 = 8.2 8.2 18 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL318247 107442 None 0 Human Functional pIC50 = 8.2 8.2 18 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
9890440 8252 None 0 Human Functional pIC50 = 8.2 8.2 301 2
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 10.1021/jm00008a002
CHEMBL10924 8252 None 0 Human Functional pIC50 = 8.2 8.2 301 2
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 10.1021/jm00008a002
11284285 107327 None 0 Human Functional pIC50 = 8.2 8.2 8 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 552 8 2 7 4.3 COc1ccc(CN2C(=O)CN[C@](c3cccc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL317510 107327 None 0 Human Functional pIC50 = 8.2 8.2 8 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 552 8 2 7 4.3 COc1ccc(CN2C(=O)CN[C@](c3cccc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11307805 107339 None 0 Human Functional pIC50 = 8.2 8.2 3 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 586 7 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Br)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL317589 107339 None 0 Human Functional pIC50 = 8.2 8.2 3 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 586 7 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Br)c3)c3ccccc32)n1 10.1021/jm031115r
11283571 207596 None 0 Human Functional pIC50 = 8.2 8.2 7 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 508 7 2 6 4.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL95013 207596 None 0 Human Functional pIC50 = 8.2 8.2 7 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 508 7 2 6 4.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3)c3ccccc32)n1 10.1021/jm031115r
11364770 163654 None 0 Human Functional pIC50 = 8.2 8.2 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL420435 163654 None 0 Human Functional pIC50 = 8.2 8.2 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3)c3ccccc32)n1 10.1021/jm031115r
10209814 207269 None 0 Human Functional pIC50 = 8.2 8.2 7 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL93084 207269 None 0 Human Functional pIC50 = 8.2 8.2 7 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3F)c3ccccc32)n1 10.1021/jm031115r
10163956 207587 None 0 Human Functional pIC50 = 8.2 8.2 10 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 500 7 3 9 1.5 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3nn[nH]n3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL94964 207587 None 0 Human Functional pIC50 = 8.2 8.2 10 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 500 7 3 9 1.5 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3nn[nH]n3)c3ccccc32)n1 10.1021/jm031115r
10166139 163342 None 0 Human Functional pIC50 = 8.2 8.2 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 550 7 2 6 4.9 Cc1cc(C)c(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c(C)c1 10.1021/jm031115r
CHEMBL419136 163342 None 0 Human Functional pIC50 = 8.2 8.2 2 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 550 7 2 6 4.9 Cc1cc(C)c(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c(C)c1 10.1021/jm031115r
11191999 207497 None 0 Human Functional pIC50 = 8.2 8.2 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)ccc3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL94438 207497 None 0 Human Functional pIC50 = 8.2 8.2 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)ccc3F)c3ccccc32)n1 10.1021/jm031115r
11375934 207911 None 0 Human Functional pIC50 = 8.2 8.2 3 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 526 7 2 6 4.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96746 207911 None 0 Human Functional pIC50 = 8.2 8.2 3 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 526 7 2 6 4.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3)c3ccccc32)n1 10.1021/jm031115r
11478911 156308 None 0 Human Functional pIC50 = 8.2 8.2 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 598 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)c(F)c(F)c(F)c3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL406551 156308 None 0 Human Functional pIC50 = 8.2 8.2 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 598 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)c(F)c(F)c(F)c3F)c3ccccc32)n1 10.1021/jm031115r
10298354 112004 None 0 Human Functional pIC50 = 8.2 8.2 15 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 462 7 3 7 1.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCO)c3ccccc32)n1 10.1021/jm031115r
CHEMBL328878 112004 None 0 Human Functional pIC50 = 8.2 8.2 15 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 462 7 3 7 1.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCO)c3ccccc32)n1 10.1021/jm031115r
345351 9357 None 4 Human Functional pIC50 = 6.2 6.2 24 3
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 386 4 1 5 3.8 O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL11131 9357 None 4 Human Functional pIC50 = 6.2 6.2 24 3
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 386 4 1 5 3.8 O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL329609 211316 None 0 Human Functional pIC50 = 5.2 5.2 3 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)[C@@H](C)CC 10.1021/jm00015a003
11202819 112562 None 0 Human Functional pIC50 = 6.2 6.2 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 499 6 3 8 3.2 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3c(C(=O)O)nc(C)n3-c3ccccc32)n1 10.1021/jm031115r
CHEMBL330045 112562 None 0 Human Functional pIC50 = 6.2 6.2 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 499 6 3 8 3.2 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3c(C(=O)O)nc(C)n3-c3ccccc32)n1 10.1021/jm031115r
11385689 112794 None 0 Human Functional pIC50 = 6.2 6.2 10 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 462 7 2 6 3.0 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)c1 10.1021/jm031115r
CHEMBL330629 112794 None 0 Human Functional pIC50 = 6.2 6.2 10 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 462 7 2 6 3.0 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)c1 10.1021/jm031115r
44283270 167879 None 0 Human Functional pIC50 = 5.2 5.2 -2691 4
Functional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptorFunctional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptor
ChEMBL 580 12 5 5 3.8 CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL431124 167879 None 0 Human Functional pIC50 = 5.2 5.2 -2691 4
Functional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptorFunctional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptor
ChEMBL 580 12 5 5 3.8 CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1016/0960-894X(95)00237-N
18995991 100298 None 0 Human Functional pIC50 = 7.2 7.2 9 2
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 537 8 1 10 5.0 COc1cc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc(OC)c1OC 10.1016/0960-894X(96)00232-6
CHEMBL28920 100298 None 0 Human Functional pIC50 = 7.2 7.2 9 2
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 537 8 1 10 5.0 COc1cc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc(OC)c1OC 10.1016/0960-894X(96)00232-6
18995992 99836 None 0 Human Functional pIC50 = 7.2 7.2 3 2
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 507 7 1 9 5.0 COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC 10.1016/0960-894X(96)00232-6
CHEMBL28563 99836 None 0 Human Functional pIC50 = 7.2 7.2 3 2
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 507 7 1 9 5.0 COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC 10.1016/0960-894X(96)00232-6
11465096 96763 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 450 6 2 7 2.5 CSc1cnc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)nc1 10.1021/jm031115r
CHEMBL264625 96763 None 0 Human Functional pIC50 = 5.2 5.2 - 1
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 450 6 2 7 2.5 CSc1cnc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)nc1 10.1021/jm031115r
11235126 207925 None 0 Human Functional pIC50 = 7.2 7.2 52 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 405 5 2 6 2.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCOc3ccccc32)n1 10.1021/jm031115r
CHEMBL96831 207925 None 0 Human Functional pIC50 = 7.2 7.2 52 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 405 5 2 6 2.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCOc3ccccc32)n1 10.1021/jm031115r
11478553 163448 None 0 Human Functional pIC50 = 8.1 8.1 10 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL419879 163448 None 0 Human Functional pIC50 = 8.1 8.1 10 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
11330570 207582 None 0 Human Functional pIC50 = 8.1 8.1 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 570 8 2 7 4.5 COc1ccc(CN2C(=O)CN[C@](c3ccc(F)c(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL94934 207582 None 0 Human Functional pIC50 = 8.1 8.1 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 570 8 2 7 4.5 COc1ccc(CN2C(=O)CN[C@](c3ccc(F)c(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11155687 207825 None 0 Human Functional pIC50 = 8.1 8.1 12 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 472 7 2 6 3.2 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CC3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96318 207825 None 0 Human Functional pIC50 = 8.1 8.1 12 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 472 7 2 6 3.2 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CC3)c3ccccc32)n1 10.1021/jm031115r
10303311 107160 None 0 Human Functional pIC50 = 8.1 8.1 9 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 566 8 2 8 3.8 COC(=O)c1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL316301 107160 None 0 Human Functional pIC50 = 8.1 8.1 9 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 566 8 2 8 3.8 COC(=O)c1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11742628 98233 None 0 Human Functional pIC50 = 8.1 8.1 25 3
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 416 5 1 6 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
CHEMBL274383 98233 None 0 Human Functional pIC50 = 8.1 8.1 25 3
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 416 5 1 6 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
11477664 168165 None 0 Human Functional pIC50 = 8.1 8.1 6 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 506 10 2 8 2.4 COCCOCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 10.1021/jm031115r
CHEMBL433173 168165 None 0 Human Functional pIC50 = 8.1 8.1 6 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 506 10 2 8 2.4 COCCOCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 10.1021/jm031115r
11204331 112577 None 0 Human Functional pIC50 = 8.1 8.1 -1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 616 10 2 6 6.1 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL330135 112577 None 0 Human Functional pIC50 = 8.1 8.1 -1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 616 10 2 6 6.1 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
11377200 108296 None 0 Human Functional pIC50 = 8.1 8.1 11 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 638 8 2 6 6.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL319754 108296 None 0 Human Functional pIC50 = 8.1 8.1 11 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 638 8 2 6 6.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
11444738 164877 None 0 Human Functional pIC50 = 8.1 8.1 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 594 11 2 7 5.4 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 10.1021/jm031115r
CHEMBL422068 164877 None 0 Human Functional pIC50 = 8.1 8.1 4 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 594 11 2 7 5.4 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 10.1021/jm031115r
11398658 207597 None 0 Human Functional pIC50 = 8.1 8.1 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)cc(F)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL95017 207597 None 0 Human Functional pIC50 = 8.1 8.1 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)cc(F)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL319719 211219 None 0 Human Functional pIC50 = 7.2 7.2 -3 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL328942 211314 None 0 Human Functional pIC50 = 7.2 7.2 1 4
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
9980487 5268 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 436 6 1 5 4.8 COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10648 5268 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 436 6 1 5 4.8 COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
10452089 4563 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 375 3 0 5 4.1 COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 10.1016/S0960-894X(96)00551-3
CHEMBL102494 4563 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 375 3 0 5 4.1 COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 10.1016/S0960-894X(96)00551-3
70694736 76211 None 0 Human Functional pIC50 = 7.1 7.1 -1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 472 6 1 6 5.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(C)nc4ccccc43)cc2)c1C 10.1016/j.bmc.2012.06.011
CHEMBL2058367 76211 None 0 Human Functional pIC50 = 7.1 7.1 -1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 472 6 1 6 5.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(C)nc4ccccc43)cc2)c1C 10.1016/j.bmc.2012.06.011
134136255 142592 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Agonist activity at ETA receptor in human SKNMC cells assessed as induction of Ca2+ mobilization by fluorimetric methodAgonist activity at ETA receptor in human SKNMC cells assessed as induction of Ca2+ mobilization by fluorimetric method
ChEMBL 663 11 2 10 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.ejmech.2016.06.006
CHEMBL3891334 142592 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Agonist activity at ETA receptor in human SKNMC cells assessed as induction of Ca2+ mobilization by fluorimetric methodAgonist activity at ETA receptor in human SKNMC cells assessed as induction of Ca2+ mobilization by fluorimetric method
ChEMBL 663 11 2 10 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.ejmech.2016.06.006
10047521 8628 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 416 6 1 5 4.4 COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10951 8628 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 416 6 1 5 4.4 COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
44332807 107233 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 447 5 0 5 6.0 O=C(OCc1ccccc1)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL316792 107233 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 447 5 0 5 6.0 O=C(OCc1ccccc1)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
44332624 4179 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 356 3 1 4 3.7 NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100120 4179 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 356 3 1 4 3.7 NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
10336018 102106 None 0 Human Functional pIC50 = 5.1 5.1 -10 2
Antagonism of ET1 induced increase in intracellular Ca+2 in rabbit carotid artery ringsAntagonism of ET1 induced increase in intracellular Ca+2 in rabbit carotid artery rings
ChEMBL 318 3 2 5 3.0 Cc1noc(NS(=O)(=O)c2cccc3c(O)cccc23)c1C 10.1021/jm00029a001
CHEMBL30228 102106 None 0 Human Functional pIC50 = 5.1 5.1 -10 2
Antagonism of ET1 induced increase in intracellular Ca+2 in rabbit carotid artery ringsAntagonism of ET1 induced increase in intracellular Ca+2 in rabbit carotid artery rings
ChEMBL 318 3 2 5 3.0 Cc1noc(NS(=O)(=O)c2cccc3c(O)cccc23)c1C 10.1021/jm00029a001
CHEMBL265614 210654 None 19 Pig Functional pIC50 = 8.1 8.1 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL269189 210780 None 0 Pig Functional pIC50 = 8.1 8.1 - 1
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
104865 705 None 99 Human Functional pIC50 = 8.1 8.1 -3 5
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2012.06.011
3494 705 None 99 Human Functional pIC50 = 8.1 8.1 -3 5
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2012.06.011
392 705 None 99 Human Functional pIC50 = 8.1 8.1 -3 5
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2012.06.011
CHEMBL957 705 None 99 Human Functional pIC50 = 8.1 8.1 -3 5
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2012.06.011
DB00559 705 None 99 Human Functional pIC50 = 8.1 8.1 -3 5
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2012.06.011
70694737 76216 None 0 Human Functional pIC50 = 8.1 8.1 -1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 544 10 1 7 6.5 CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058372 76216 None 0 Human Functional pIC50 = 8.1 8.1 -1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 544 10 1 7 6.5 CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
11432418 106946 None 0 Human Functional pIC50 = 8.1 8.1 6 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C)c3ccccc32)n1 10.1021/jm031115r
CHEMBL314946 106946 None 0 Human Functional pIC50 = 8.1 8.1 6 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C)c3ccccc32)n1 10.1021/jm031115r
44332638 4374 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 477 6 0 6 6.0 COc1ccc(COC(=O)C(c2ccc3c(c2)OCO3)c2c3ccccc3nc3ccccc23)cc1 10.1016/S0960-894X(96)00551-3
CHEMBL101239 4374 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 477 6 0 6 6.0 COc1ccc(COC(=O)C(c2ccc3c(c2)OCO3)c2c3ccccc3nc3ccccc23)cc1 10.1016/S0960-894X(96)00551-3
11489174 112546 None 0 Human Functional pIC50 = 7.1 7.1 -1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 514 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CCCCC3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL329943 112546 None 0 Human Functional pIC50 = 7.1 7.1 -1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 514 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CCCCC3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL216082 209315 None 0 Human Functional pIC50 = 6.1 6.1 -20 2
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44332624 4179 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 356 3 1 4 3.7 NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100120 4179 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 356 3 1 4 3.7 NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
44332546 107211 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 491 5 0 7 5.7 O=C(OCc1ccc2c(c1)OCO2)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL316648 107211 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 491 5 0 7 5.7 O=C(OCc1ccc2c(c1)OCO2)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
9955200 9330 None 0 Human Functional pIC50 = 8.1 8.1 53 3
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 446 6 1 7 3.8 COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL11115 9330 None 0 Human Functional pIC50 = 8.1 8.1 53 3
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 446 6 1 7 3.8 COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
11376627 107630 None 0 Human Functional pIC50 = 8.0 8.0 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(C(F)(F)F)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL319007 107630 None 0 Human Functional pIC50 = 8.0 8.0 1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(C(F)(F)F)c3)c3ccccc32)n1 10.1021/jm031115r
11307457 207609 None 0 Human Functional pIC50 = 8.0 8.0 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 556 8 2 7 4.2 COc1ccc(CN2C(=O)CN[C@](c3cccc(F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL95095 207609 None 0 Human Functional pIC50 = 8.0 8.0 5 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 556 8 2 7 4.2 COc1ccc(CN2C(=O)CN[C@](c3cccc(F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
70684239 76215 None 0 Human Functional pIC50 = 8.0 8.0 -1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 528 9 1 6 6.8 CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058371 76215 None 0 Human Functional pIC50 = 8.0 8.0 -1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 528 9 1 6 6.8 CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
70694738 76217 None 0 Human Functional pIC50 = 8.0 8.0 1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 548 9 1 6 7.2 CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058373 76217 None 0 Human Functional pIC50 = 8.0 8.0 1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 548 9 1 6 7.2 CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
70686382 76214 None 0 Human Functional pIC50 = 8.0 8.0 1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 514 9 1 6 6.5 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058370 76214 None 0 Human Functional pIC50 = 8.0 8.0 1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 514 9 1 6 6.5 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
70696780 76218 None 0 Human Functional pIC50 = 8.0 8.0 1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 592 9 1 6 7.3 CCCCc1nc2ccc(Br)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058374 76218 None 0 Human Functional pIC50 = 8.0 8.0 1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 592 9 1 6 7.3 CCCCc1nc2ccc(Br)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
44213651 4296 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 343 3 1 4 4.2 OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100795 4296 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 343 3 1 4 4.2 OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
11441050 207829 None 0 Human Functional pIC50 = 7.0 7.0 85 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 403 5 2 5 3.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCCc3ccccc32)n1 10.1021/jm031115r
CHEMBL96331 207829 None 0 Human Functional pIC50 = 7.0 7.0 85 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 403 5 2 5 3.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCCc3ccccc32)n1 10.1021/jm031115r
11488556 207867 None 0 Human Functional pIC50 = 6.0 6.0 10 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 482 5 2 6 2.6 CN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2ncc(Br)cn2)C(=O)O)c2ccccc21 10.1021/jm031115r
CHEMBL96520 207867 None 0 Human Functional pIC50 = 6.0 6.0 10 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 482 5 2 6 2.6 CN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2ncc(Br)cn2)C(=O)O)c2ccccc21 10.1021/jm031115r
9980487 5268 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 436 6 1 5 4.8 COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10648 5268 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 436 6 1 5 4.8 COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
11456110 207837 None 0 Human Functional pIC50 = 7.0 7.0 -1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 592 8 2 7 4.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3OC(F)(F)F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96387 207837 None 0 Human Functional pIC50 = 7.0 7.0 -1 2
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 592 8 2 7 4.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3OC(F)(F)F)c3ccccc32)n1 10.1021/jm031115r
70686380 76210 None 0 Human Functional pIC50 = 7 7.0 -1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 458 6 1 6 5.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3cnc4ccccc43)cc2)c1C 10.1016/j.bmc.2012.06.011
CHEMBL2058366 76210 None 0 Human Functional pIC50 = 7 7.0 -1 2
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 458 6 1 6 5.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3cnc4ccccc43)cc2)c1C 10.1016/j.bmc.2012.06.011
44311232 204105 None 0 Rat Functional pKd = 10 10.0 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 658 13 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70293 204105 None 0 Rat Functional pKd = 10 10.0 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 658 13 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
9939238 204126 None 0 Rat Functional pKd = 9.7 9.7 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 637 12 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70385 204126 None 0 Rat Functional pKd = 9.7 9.7 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 637 12 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
9809919 204407 None 0 Rat Functional pKd = 9.3 9.3 - 2
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 665 13 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL72037 204407 None 0 Rat Functional pKd = 9.3 9.3 - 2
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 665 13 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44212539 204091 None 0 Rat Functional pKd = 9 9.0 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 671 12 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70203 204091 None 0 Rat Functional pKd = 9 9.0 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 671 12 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44311233 204107 None 0 Rat Functional pKd = 9 9.0 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 630 12 2 13 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70303 204107 None 0 Rat Functional pKd = 9 9.0 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 630 12 2 13 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44311516 204116 None 0 Rat Functional pKd = 8 8.0 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 678 12 2 12 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70339 204116 None 0 Rat Functional pKd = 8 8.0 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 678 12 2 12 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44311527 204121 None 0 Rat Functional pKd = 8 8.0 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 675 12 2 11 7.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2cccs2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70365 204121 None 0 Rat Functional pKd = 8 8.0 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 675 12 2 11 7.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2cccs2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
18184234 62207 None 0 Rat Functional pKd = 7.0 7.0 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 605 15 2 10 4.2 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL177802 62207 None 0 Rat Functional pKd = 7.0 7.0 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 605 15 2 10 4.2 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9807456 60471 None 0 Rat Functional pKd = 7.0 7.0 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 545 9 1 9 4.8 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL175435 60471 None 0 Rat Functional pKd = 7.0 7.0 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 545 9 1 9 4.8 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
44311285 102297 None 0 Rat Functional pKd = 7.9 7.9 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 635 13 2 10 6.4 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOC(=O)Nc2ccccn2)n1 10.1016/S0960-894X(97)00400-9
CHEMBL303428 102297 None 0 Rat Functional pKd = 7.9 7.9 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 635 13 2 10 6.4 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOC(=O)Nc2ccccn2)n1 10.1016/S0960-894X(97)00400-9
9917706 129737 None 0 Rat Functional pKd = 6.9 6.9 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 659 15 2 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL367444 129737 None 0 Rat Functional pKd = 6.9 6.9 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 659 15 2 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
9869444 97244 None 0 Human Functional pKd = 6.9 6.9 120 2
Inhibition of contraction of ET-1 induced rabbit femoral artery, which are known to express predominantly ETA receptorsInhibition of contraction of ET-1 induced rabbit femoral artery, which are known to express predominantly ETA receptors
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 10.1016/0960-894X(96)00170-9
CHEMBL268751 97244 None 0 Human Functional pKd = 6.9 6.9 120 2
Inhibition of contraction of ET-1 induced rabbit femoral artery, which are known to express predominantly ETA receptorsInhibition of contraction of ET-1 induced rabbit femoral artery, which are known to express predominantly ETA receptors
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 10.1016/0960-894X(96)00170-9
9848132 207575 None 0 Rat Functional pKd = 5.9 5.9 120 2
Compound was evaluated for the antagonism at the Endothelin A receptor in isolated rat aortic ringsCompound was evaluated for the antagonism at the Endothelin A receptor in isolated rat aortic rings
ChEMBL 483 6 1 8 2.8 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL94918 207575 None 0 Rat Functional pKd = 5.9 5.9 120 2
Compound was evaluated for the antagonism at the Endothelin A receptor in isolated rat aortic ringsCompound was evaluated for the antagonism at the Endothelin A receptor in isolated rat aortic rings
ChEMBL 483 6 1 8 2.8 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
10281606 129670 None 0 Rat Functional pKd = 6.8 6.8 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 575 9 2 10 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL367382 129670 None 0 Rat Functional pKd = 6.8 6.8 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 575 9 2 10 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
44311284 204243 None 0 Rat Functional pKd = 7.8 7.8 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 635 12 2 10 6.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL71070 204243 None 0 Rat Functional pKd = 7.8 7.8 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 635 12 2 10 6.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44311346 103161 None 0 Rat Functional pKd = 6.8 6.8 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 681 13 2 13 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCSCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL308088 103161 None 0 Rat Functional pKd = 6.8 6.8 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 681 13 2 13 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCSCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL1790962 208908 None 0 Pig Functional pKd = 7.7 7.7 -2 2
ETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary arteryETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary artery
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
CHEMBL2373291 210372 None 0 Pig Functional pKd = 7.7 7.7 -1 2
ETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary arteryETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary artery
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
44311528 204140 None 0 Rat Functional pKd = 7.7 7.7 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 633 12 2 10 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70487 204140 None 0 Rat Functional pKd = 7.7 7.7 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 633 12 2 10 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
10122675 98470 None 0 Rat Functional pKd = 7.7 7.7 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 682 12 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL275897 98470 None 0 Rat Functional pKd = 7.7 7.7 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 682 12 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
10146640 207552 None 0 Rat Functional pKd = 7.7 7.7 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 689 12 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL94786 207552 None 0 Rat Functional pKd = 7.7 7.7 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 689 12 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
10212088 96694 None 0 Rat Functional pKd = 6.7 6.7 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 688 12 2 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL264035 96694 None 0 Rat Functional pKd = 6.7 6.7 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 688 12 2 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
10211772 56521 None 0 Rat Functional pKd = 6.6 6.6 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 660 11 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL163638 56521 None 0 Rat Functional pKd = 6.6 6.6 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 660 11 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
9917072 62101 None 0 Rat Functional pKd = 6.6 6.6 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 619 16 2 10 4.6 CCCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL177538 62101 None 0 Rat Functional pKd = 6.6 6.6 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 619 16 2 10 4.6 CCCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9809270 131338 None 0 Rat Functional pKd = 6.6 6.6 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 622 14 2 12 2.3 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL368738 131338 None 0 Rat Functional pKd = 6.6 6.6 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 622 14 2 12 2.3 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9870830 206712 None 38 Human Functional pKd = 7.6 7.6 -1 5
Antagonism of ET-1 induced contraction of rabbit femoral artery rings (Endothelin A receptor mediated)Antagonism of ET-1 induced contraction of rabbit femoral artery rings (Endothelin A receptor mediated)
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
CHEMBL8981 206712 None 38 Human Functional pKd = 7.6 7.6 -1 5
Antagonism of ET-1 induced contraction of rabbit femoral artery rings (Endothelin A receptor mediated)Antagonism of ET-1 induced contraction of rabbit femoral artery rings (Endothelin A receptor mediated)
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
44311283 102331 None 0 Rat Functional pKd = 7.6 7.6 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 649 11 2 10 6.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL303649 102331 None 0 Rat Functional pKd = 7.6 7.6 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 649 11 2 10 6.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
23670447 3027 None 2 Human Functional pKd = 7.6 7.6 1 4
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(97)10151-2
999 3027 None 2 Human Functional pKd = 7.6 7.6 1 4
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(97)10151-2
CHEMBL1204799 3027 None 2 Human Functional pKd = 7.6 7.6 1 4
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(97)10151-2
CHEMBL25438 3027 None 2 Human Functional pKd = 7.6 7.6 1 4
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(97)10151-2
44386169 131387 None 0 Rat Functional pKd = 7.6 7.6 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 690 12 2 14 3.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL368996 131387 None 0 Rat Functional pKd = 7.6 7.6 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 690 12 2 14 3.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
10190108 130696 None 0 Rat Functional pKd = 7.6 7.6 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 681 12 2 12 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL368386 130696 None 0 Rat Functional pKd = 7.6 7.6 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 681 12 2 12 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
10211781 129739 None 0 Rat Functional pKd = 7.6 7.6 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL367453 129739 None 0 Rat Functional pKd = 7.6 7.6 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
18184229 59606 None 0 Rat Functional pKd = 6.5 6.5 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 605 15 2 10 4.2 CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL171950 59606 None 0 Rat Functional pKd = 6.5 6.5 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 605 15 2 10 4.2 CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9894460 206707 None 9 Rat Functional pKd = 8.5 8.5 -158 4
Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00617-8
CHEMBL313871 206707 None 9 Rat Functional pKd = 8.5 8.5 -158 4
Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00617-8
CHEMBL8978 206707 None 9 Rat Functional pKd = 8.5 8.5 -158 4
Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00617-8
10311570 14628 None 0 Human Functional pKd = 8.5 8.5 - 2
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 520 10 1 9 4.7 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(97)10151-2
CHEMBL1205068 14628 None 0 Human Functional pKd = 8.5 8.5 - 2
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 520 10 1 9 4.7 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(97)10151-2
CHEMBL48907 14628 None 0 Human Functional pKd = 8.5 8.5 - 2
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 520 10 1 9 4.7 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(97)10151-2
9830495 131147 None 0 Rat Functional pKd = 6.5 6.5 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 618 14 2 9 5.0 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL368617 131147 None 0 Rat Functional pKd = 6.5 6.5 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 618 14 2 9 5.0 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9874557 129736 None 0 Rat Functional pKd = 6.5 6.5 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 667 15 2 10 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL367443 129736 None 0 Rat Functional pKd = 6.5 6.5 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 667 15 2 10 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
9864880 102386 None 0 Human Functional pKd = 7.5 7.5 - 1
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 384 4 1 6 3.7 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc4nsnc4c3)cccc12 10.1016/s0960-894x(97)10151-2
CHEMBL303902 102386 None 0 Human Functional pKd = 7.5 7.5 - 1
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 384 4 1 6 3.7 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc4nsnc4c3)cccc12 10.1016/s0960-894x(97)10151-2
9810571 61384 None 0 Rat Functional pKd = 5.5 5.5 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 731 18 2 13 5.0 CCCS(=O)(=O)NCCOc1nc(-c2cc(OC)c(OC)c(OC)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL176997 61384 None 0 Rat Functional pKd = 5.5 5.5 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 731 18 2 13 5.0 CCCS(=O)(=O)NCCOc1nc(-c2cc(OC)c(OC)c(OC)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9873255 59632 None 0 Rat Functional pKd = 6.5 6.5 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 591 14 2 10 3.8 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL172071 59632 None 0 Rat Functional pKd = 6.5 6.5 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 591 14 2 10 3.8 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL2373292 210373 None 0 Pig Functional pKd = 7.4 7.4 -2 2
ETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary arteryETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary artery
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
44298982 195618 None 0 Rat Functional pKd = 6.4 6.4 - 0
Functional antagonism against ETA receptor in rat aortic rings expressed as pA2 valueFunctional antagonism against ETA receptor in rat aortic rings expressed as pA2 value
ChEMBL 445 7 1 6 5.2 CCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc(OC)cc1 10.1016/S0960-894X(97)00319-3
CHEMBL55621 195618 None 0 Rat Functional pKd = 6.4 6.4 - 0
Functional antagonism against ETA receptor in rat aortic rings expressed as pA2 valueFunctional antagonism against ETA receptor in rat aortic rings expressed as pA2 value
ChEMBL 445 7 1 6 5.2 CCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc(OC)cc1 10.1016/S0960-894X(97)00319-3
10122442 130695 None 0 Rat Functional pKd = 6.4 6.4 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 660 14 2 11 5.6 CCCCNC(=O)OCC#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL368383 130695 None 0 Rat Functional pKd = 6.4 6.4 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 660 14 2 11 5.6 CCCCNC(=O)OCC#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
18184194 130560 None 0 Rat Functional pKd = 5.3 5.3 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 712 15 2 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL368107 130560 None 0 Rat Functional pKd = 5.3 5.3 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 712 15 2 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
44311345 204215 None 0 Rat Functional pKd = 8.3 8.3 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 663 13 3 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CCNCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70895 204215 None 0 Rat Functional pKd = 8.3 8.3 - 2
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 663 13 3 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CCNCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
104865 705 None 99 Rat Functional pKd = 7.3 7.3 1 5
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
3494 705 None 99 Rat Functional pKd = 7.3 7.3 1 5
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
392 705 None 99 Rat Functional pKd = 7.3 7.3 1 5
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
CHEMBL957 705 None 99 Rat Functional pKd = 7.3 7.3 1 5
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
DB00559 705 None 99 Rat Functional pKd = 7.3 7.3 1 5
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
10005597 119816 None 0 Rat Functional pKd = 6.3 6.3 1 2
In vitro antagonistic activity against endothelin A receptor in isolated rat aortic ringsIn vitro antagonistic activity against endothelin A receptor in isolated rat aortic rings
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL348407 119816 None 0 Rat Functional pKd = 6.3 6.3 1 2
In vitro antagonistic activity against endothelin A receptor in isolated rat aortic ringsIn vitro antagonistic activity against endothelin A receptor in isolated rat aortic rings
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
10168597 61335 None 0 Rat Functional pKd = 6.3 6.3 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cccnc1 10.1016/s0960-894x(02)01084-3
CHEMBL176741 61335 None 0 Rat Functional pKd = 6.3 6.3 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cccnc1 10.1016/s0960-894x(02)01084-3
CHEMBL411171 212865 None 0 Pig Functional pKd = 5.3 5.3 -19 2
ETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary arteryETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary artery
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00077a013
10233400 128683 None 0 Rat Functional pKd = 7.3 7.3 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccncc1 10.1016/s0960-894x(02)01084-3
CHEMBL366885 128683 None 0 Rat Functional pKd = 7.3 7.3 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccncc1 10.1016/s0960-894x(02)01084-3
10305334 129045 None 0 Rat Functional pKd = 6.3 6.3 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 680 12 2 11 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL367036 129045 None 0 Rat Functional pKd = 6.3 6.3 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 680 12 2 11 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
192311 107272 None 4 Pig Functional pKd = 7.2 7.2 - 1
Antagonistic activity towards ET- l-induced contraction in porcine coronary arteriesAntagonistic activity towards ET- l-induced contraction in porcine coronary arteries
ChEMBL 513 11 5 4 2.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31702 107272 None 4 Pig Functional pKd = 7.2 7.2 - 1
Antagonistic activity towards ET- l-induced contraction in porcine coronary arteriesAntagonistic activity towards ET- l-induced contraction in porcine coronary arteries
ChEMBL 513 11 5 4 2.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
10457385 112686 None 0 Rat Functional pKd = 6.2 6.2 85 2
Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL330424 112686 None 0 Rat Functional pKd = 6.2 6.2 85 2
Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
11755275 200007 None 0 Rat Functional pKd = 5.2 5.2 -1 2
Functional antagonism against ETA receptor in rat aortic rings expressed as pA2 valueFunctional antagonism against ETA receptor in rat aortic rings expressed as pA2 value
ChEMBL 489 9 1 7 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1cc(OC)ccc1OC 10.1016/S0960-894X(97)00319-3
CHEMBL59537 200007 None 0 Rat Functional pKd = 5.2 5.2 -1 2
Functional antagonism against ETA receptor in rat aortic rings expressed as pA2 valueFunctional antagonism against ETA receptor in rat aortic rings expressed as pA2 value
ChEMBL 489 9 1 7 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1cc(OC)ccc1OC 10.1016/S0960-894X(97)00319-3
9831249 59695 None 0 Rat Functional pKd = 6.2 6.2 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 672 14 2 10 6.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL172297 59695 None 0 Rat Functional pKd = 6.2 6.2 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 672 14 2 10 6.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
10146377 60412 None 0 Rat Functional pKd = 8.1 8.1 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 662 11 2 14 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL175058 60412 None 0 Rat Functional pKd = 8.1 8.1 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 662 11 2 14 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
44384715 60360 None 0 Rat Functional pKd = 7.2 7.2 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 559 9 1 9 5.2 CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL174607 60360 None 0 Rat Functional pKd = 7.2 7.2 - 2
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 559 9 1 9 5.2 CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
104865 705 None 99 Rat Functional pKd = 7.1 7.1 1 5
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
3494 705 None 99 Rat Functional pKd = 7.1 7.1 1 5
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
392 705 None 99 Rat Functional pKd = 7.1 7.1 1 5
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
CHEMBL957 705 None 99 Rat Functional pKd = 7.1 7.1 1 5
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
DB00559 705 None 99 Rat Functional pKd = 7.1 7.1 1 5
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
9853077 59625 None 0 Rat Functional pKd = 6.1 6.1 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 696 13 2 12 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL172030 59625 None 0 Rat Functional pKd = 6.1 6.1 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 696 13 2 12 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
9961131 132155 None 0 Rat Functional pKd = 6.1 6.1 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 650 15 2 12 3.1 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL369676 132155 None 0 Rat Functional pKd = 6.1 6.1 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 650 15 2 12 3.1 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9830773 130224 None 0 Rat Functional pKd = 7.0 7.0 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 636 14 2 12 2.8 CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL367958 130224 None 0 Rat Functional pKd = 7.0 7.0 - 2
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 636 14 2 12 2.8 CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
10096179 177018 None 0 Human Functional pKi = 8.7 8.7 - 0
Antagonist activity against human ETA receptor using CHO cellsAntagonist activity against human ETA receptor using CHO cells
ChEMBL 468 9 1 5 5.7 CCOc1ccc(-c2cc(C)nc(OC(C(=O)O)C(C)(c3ccccc3)c3ccccc3)n2)cc1 10.1016/s0960-894x(03)00236-1
CHEMBL46311 177018 None 0 Human Functional pKi = 8.7 8.7 - 0
Antagonist activity against human ETA receptor using CHO cellsAntagonist activity against human ETA receptor using CHO cells
ChEMBL 468 9 1 5 5.7 CCOc1ccc(-c2cc(C)nc(OC(C(=O)O)C(C)(c3ccccc3)c3ccccc3)n2)cc1 10.1016/s0960-894x(03)00236-1
10070 449 None 47 Human Functional pA2 = 6.7 6.7 109 2
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
25099191 449 None 47 Human Functional pA2 = 6.7 6.7 109 2
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
CHEMBL2165326 449 None 47 Human Functional pA2 = 6.7 6.7 109 2
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
DB15059 449 None 47 Human Functional pA2 = 6.7 6.7 109 2
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
3951 391 None 86 Human Functional pA2 = 7.1 7.1 47 2
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
4337 391 None 86 Human Functional pA2 = 7.1 7.1 47 2
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
6918493 391 None 86 Human Functional pA2 = 7.1 7.1 47 2
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
CHEMBL1111 391 None 86 Human Functional pA2 = 7.1 7.1 47 2
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
DB06403 391 None 86 Human Functional pA2 = 7.1 7.1 47 2
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
443289 710 None 47 Human Functional pA2 = 7.2 7.2 1 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
997 710 None 47 Human Functional pA2 = 7.2 7.2 1 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
CHEMBL314691 710 None 47 Human Functional pA2 = 7.2 7.2 1 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
DB12054 710 None 47 Human Functional pA2 = 7.2 7.2 1 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
104865 705 None 99 Rat Functional pA2 = 7.2 7.2 1 5
UnclassifiedUnclassified
Guide to Pharmacology 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 8035319
3494 705 None 99 Rat Functional pA2 = 7.2 7.2 1 5
UnclassifiedUnclassified
Guide to Pharmacology 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 8035319
392 705 None 99 Rat Functional pA2 = 7.2 7.2 1 5
UnclassifiedUnclassified
Guide to Pharmacology 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 8035319
CHEMBL957 705 None 99 Rat Functional pA2 = 7.2 7.2 1 5
UnclassifiedUnclassified
Guide to Pharmacology 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 8035319
DB00559 705 None 99 Rat Functional pA2 = 7.2 7.2 1 5
UnclassifiedUnclassified
Guide to Pharmacology 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 8035319
11477084 3608 None 53 Human Functional pA2 = 8 8.0 58 2
UnclassifiedUnclassified
Guide to Pharmacology 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 9171878
216235 3608 None 53 Human Functional pA2 = 8 8.0 58 2
UnclassifiedUnclassified
Guide to Pharmacology 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 9171878
3548 3608 None 53 Human Functional pA2 = 8 8.0 58 2
UnclassifiedUnclassified
Guide to Pharmacology 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 9171878
3950 3608 None 53 Human Functional pA2 = 8 8.0 58 2
UnclassifiedUnclassified
Guide to Pharmacology 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 9171878
CHEMBL282724 3608 None 53 Human Functional pA2 = 8 8.0 58 2
UnclassifiedUnclassified
Guide to Pharmacology 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 9171878
DB06268 3608 None 53 Human Functional pA2 = 8 8.0 58 2
UnclassifiedUnclassified
Guide to Pharmacology 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 9171878
3913 3735 None 0 Rat Functional pA2 = 8.4 8.4 -1 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7780649
5311469 3735 None 0 Rat Functional pA2 = 8.4 8.4 -1 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7780649
23670447 3027 None 2 Human Functional pA2 = 8.7 8.7 1 4
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10066864
23670447 3027 None 2 Human Functional pA2 = 8.7 8.7 1 4
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
999 3027 None 2 Human Functional pA2 = 8.7 8.7 1 4
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10066864
999 3027 None 2 Human Functional pA2 = 8.7 8.7 1 4
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
CHEMBL1204799 3027 None 2 Human Functional pA2 = 8.7 8.7 1 4
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10066864
CHEMBL1204799 3027 None 2 Human Functional pA2 = 8.7 8.7 1 4
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
CHEMBL25438 3027 None 2 Human Functional pA2 = 8.7 8.7 1 4
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10066864
CHEMBL25438 3027 None 2 Human Functional pA2 = 8.7 8.7 1 4
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
159594 522 None 45 Human Functional pA2 = 9.2 9.2 2 4
UnclassifiedUnclassified
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
3487 522 None 45 Human Functional pA2 = 9.2 9.2 2 4
UnclassifiedUnclassified
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
CHEMBL9194 522 None 45 Human Functional pA2 = 9.2 9.2 2 4
UnclassifiedUnclassified
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
DB06199 522 None 45 Human Functional pA2 = 9.2 9.2 2 4
UnclassifiedUnclassified
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
12286 947 None 36 Human Functional pA2 = 9.5 9.5 234 2
UnclassifiedUnclassified
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9399983
6433095 947 None 36 Human Functional pA2 = 9.5 9.5 234 2
UnclassifiedUnclassified
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9399983
CHEMBL109648 947 None 36 Human Functional pA2 = 9.5 9.5 234 2
UnclassifiedUnclassified
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9399983
DB06677 947 None 36 Human Functional pA2 = 9.5 9.5 234 2
UnclassifiedUnclassified
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9399983
5340 168728 None 106 Human Functional pIC50 = 8.4 8.4 1 3
NoneNone
Drug Central 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 None
CHEMBL437 168728 None 106 Human Functional pIC50 = 8.4 8.4 1 3
NoneNone
Drug Central 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 None
5344 173471 None 101 Human Functional pIC50 = 8.2 8.2 -100 6
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
Drug Central 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C None
CHEMBL453 173471 None 101 Human Functional pIC50 = 8.2 8.2 -100 6
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
Drug Central 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C None
6662 217737 None 0 Human Functional pIC50 = 8.2 8.2 -1 3
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
Drug Central 309 3 1 6 1.6 CC(=O)N(C1=C(C)C(C)=NO1)S(=O)(=O)C1=CC=C(N)C=C1 None
8260 531 None 54 Human Functional pIC50 = 7.3 7.3 141 2
UnclassifiedUnclassified
Guide to Pharmacology 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 None
9912992 531 None 54 Human Functional pIC50 = 7.3 7.3 141 2
UnclassifiedUnclassified
Guide to Pharmacology 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 None
CHEMBL3989834 531 None 54 Human Functional pIC50 = 7.3 7.3 141 2
UnclassifiedUnclassified
Guide to Pharmacology 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 None
107810 1682 None 30 Human Functional pIC50 = 7.6 7.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 7647976
998 1682 None 30 Human Functional pIC50 = 7.6 7.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 7647976
CHEMBL352396 1682 None 30 Human Functional pIC50 = 7.6 7.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 7647976
3951 391 None 86 Human Functional pIC50 = 7.7 7.7 47 2
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
4337 391 None 86 Human Functional pIC50 = 7.7 7.7 47 2
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
6918493 391 None 86 Human Functional pIC50 = 7.7 7.7 47 2
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
CHEMBL1111 391 None 86 Human Functional pIC50 = 7.7 7.7 47 2
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
DB06403 391 None 86 Human Functional pIC50 = 7.7 7.7 47 2
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
3539 4139 None 83 Human Functional pIC50 = 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 15956965
9910224 4139 None 83 Human Functional pIC50 = 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 15956965
CHEMBL1628688 4139 None 83 Human Functional pIC50 = 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 15956965
DB06629 4139 None 83 Human Functional pIC50 = 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 15956965
10070 449 None 47 Human Functional pIC50 = 8.5 8.5 109 2
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
25099191 449 None 47 Human Functional pIC50 = 8.5 8.5 109 2
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
CHEMBL2165326 449 None 47 Human Functional pIC50 = 8.5 8.5 109 2
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
DB15059 449 None 47 Human Functional pIC50 = 8.5 8.5 109 2
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
1000 3501 None 0 Human Functional pIC50 = 8.9 8.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 614 14 2 9 6.1 CCCCn1ncc(c1c1ccc(cc1OCc1ccccc1C(=O)O)OC)/C=C(/C(=O)O)\Cc1cc2OCOc2cc1OC 9694916
5311425 3501 None 0 Human Functional pIC50 = 8.9 8.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 614 14 2 9 6.1 CCCCn1ncc(c1c1ccc(cc1OCc1ccccc1C(=O)O)OC)/C=C(/C(=O)O)\Cc1cc2OCOc2cc1OC 9694916
CHEMBL1628624 3501 None 0 Human Functional pIC50 = 8.9 8.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 614 14 2 9 6.1 CCCCn1ncc(c1c1ccc(cc1OCc1ccccc1C(=O)O)OC)/C=C(/C(=O)O)\Cc1cc2OCOc2cc1OC 9694916
16004692 2452 None 91 Human Functional pIC50 = 9.3 9.3 107 2
UnclassifiedUnclassified
Guide to Pharmacology 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 22862294
4809 2452 None 91 Human Functional pIC50 = 9.3 9.3 107 2
UnclassifiedUnclassified
Guide to Pharmacology 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 22862294
7352 2452 None 91 Human Functional pIC50 = 9.3 9.3 107 2
UnclassifiedUnclassified
Guide to Pharmacology 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 22862294
CHEMBL2103873 2452 None 91 Human Functional pIC50 = 9.3 9.3 107 2
UnclassifiedUnclassified
Guide to Pharmacology 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 22862294
DB08932 2452 None 91 Human Functional pIC50 = 9.3 9.3 107 2
UnclassifiedUnclassified
Guide to Pharmacology 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 22862294
131845706 3470 None 6 Human Functional pIC50 None 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
71308726 3470 None 6 Human Functional pIC50 None 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
995 3470 None 6 Human Functional pIC50 None 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
CHEMBL1222310 3470 None 6 Human Functional pIC50 None 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
CHEMBL4524099 3470 None 6 Human Functional pIC50 None 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
101598716 1560 None 30 Human Functional pIC50 None 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
16133807 1560 None 30 Human Functional pIC50 None 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
16212950 1560 None 30 Human Functional pIC50 None 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
989 1560 None 30 Human Functional pIC50 None 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
CHEMBL3775234 1560 None 30 Human Functional pIC50 None 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
16133808 1561 None 0 Human Functional pIC50 None 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
16219332 1561 None 0 Human Functional pIC50 None 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
56947103 1561 None 0 Human Functional pIC50 None 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
990 1561 None 0 Human Functional pIC50 None 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
CHEMBL3774897 1561 None 0 Human Functional pIC50 None 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7647976
108002 3492 None 23 Rat Functional pKB = 9.4 9.4 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 8201588
3528 3492 None 23 Rat Functional pKB = 9.4 9.4 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 8201588
CHEMBL8823 3492 None 23 Rat Functional pKB = 9.4 9.4 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 8201588


Get vendors


Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
28230148 205729 None 97 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 320 3 2 6 0.7 CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)nc21 10.1038/s41467-023-40064-9
3229 205729 None 97 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 320 3 2 6 0.7 CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)nc21 10.1038/s41467-023-40064-9
CHEMBL826 205729 None 97 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 320 3 2 6 0.7 CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)nc21 10.1038/s41467-023-40064-9
41684 31219 None 105 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
CHEMBL1401 31219 None 105 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
54677470 200549 None 115 Human Binding pAC50 = 4.9 4.9 - 30
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 10.1038/s41467-023-40064-9
CHEMBL1256873 200549 None 115 Human Binding pAC50 = 4.9 4.9 - 30
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 10.1038/s41467-023-40064-9
CHEMBL599 200549 None 115 Human Binding pAC50 = 4.9 4.9 - 30
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 10.1038/s41467-023-40064-9
4829 199954 None 108 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 356 7 1 5 3.2 CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1 10.1038/s41467-023-40064-9
CHEMBL595 199954 None 108 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 356 7 1 5 3.2 CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1 10.1038/s41467-023-40064-9
104865 705 None 99 Human Binding pAC50 = 7.5 7.5 1 4
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1038/s41467-023-40064-9
3494 705 None 99 Human Binding pAC50 = 7.5 7.5 1 4
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1038/s41467-023-40064-9
392 705 None 99 Human Binding pAC50 = 7.5 7.5 1 4
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1038/s41467-023-40064-9
CHEMBL957 705 None 99 Human Binding pAC50 = 7.5 7.5 1 4
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1038/s41467-023-40064-9
DB00559 705 None 99 Human Binding pAC50 = 7.5 7.5 1 4
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1038/s41467-023-40064-9
1209 1656 None 75 Human Binding pAC50 = 5.1 5.1 - 32
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
203 1656 None 75 Human Binding pAC50 = 5.1 5.1 - 32
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
3386 1656 None 75 Human Binding pAC50 = 5.1 5.1 - 32
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL41 1656 None 75 Human Binding pAC50 = 5.1 5.1 - 32
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
DB00472 1656 None 75 Human Binding pAC50 = 5.1 5.1 - 32
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
5329102 194724 None 86 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
CHEMBL535 194724 None 86 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
135398513 66117 None 133 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 225 4 3 8 -0.9 Nc1nc(O)c2ncn(COCCO)c2n1 10.1038/s41467-023-40064-9
CHEMBL184 66117 None 133 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 225 4 3 8 -0.9 Nc1nc(O)c2ncn(COCCO)c2n1 10.1038/s41467-023-40064-9
CHEMBL2370066 209775 None 0 Human Binding pEC50 = 7.9 7.9 - 0
Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cellsEffective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL315841 211191 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cellsEffective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00070a001
CHEMBL2370067 209776 None 0 Human Binding pEC50 = 5.7 5.7 - 0
Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cellsEffective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](N)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@H](C=O)Cc1c[nH]c2ccccc12)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL407269 212649 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cellsEffective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL313344 211110 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cellsEffective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL387200 212406 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cellsEffective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL86703 215887 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cellsEffective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C 10.1021/jm00070a001
44284437 99982 None 0 Human Binding pIC50 = 11.0 11.0 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 4 8 3.5 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL286621 99982 None 0 Human Binding pIC50 = 11.0 11.0 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 4 8 3.5 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 10.1016/j.bmcl.2004.01.008
44284405 100354 None 0 Human Binding pIC50 = 11.0 11.0 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 2 7 5.4 COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
CHEMBL289634 100354 None 0 Human Binding pIC50 = 11.0 11.0 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 2 7 5.4 COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
44284287 161245 None 0 Human Binding pIC50 = 11.0 11.0 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 3 7 5.2 CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
CHEMBL411925 161245 None 0 Human Binding pIC50 = 11.0 11.0 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 3 7 5.2 CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
11017304 114138 None 0 Pig Binding pIC50 = 10.9 10.9 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 579 11 1 9 5.8 CCc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(SC)cn2)cc1 10.1021/jm0102304
CHEMBL332922 114138 None 0 Pig Binding pIC50 = 10.9 10.9 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 579 11 1 9 5.8 CCc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(SC)cn2)cc1 10.1021/jm0102304
44284288 100133 None 0 Human Binding pIC50 = 10.9 10.9 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 559 9 2 7 4.9 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 10.1016/j.bmcl.2004.01.008
CHEMBL287683 100133 None 0 Human Binding pIC50 = 10.9 10.9 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 559 9 2 7 4.9 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 10.1016/j.bmcl.2004.01.008
44284292 168110 None 0 Human Binding pIC50 = 10.9 10.9 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 8 3 7 4.9 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)(C)O)c1 10.1016/j.bmcl.2004.01.008
CHEMBL432856 168110 None 0 Human Binding pIC50 = 10.9 10.9 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 8 3 7 4.9 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)(C)O)c1 10.1016/j.bmcl.2004.01.008
9852318 9612 None 8 Rat Binding pIC50 = 10.8 10.8 - 2
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL112624 9612 None 8 Rat Binding pIC50 = 10.8 10.8 - 2
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL1627022 9612 None 8 Rat Binding pIC50 = 10.8 10.8 - 2
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1016/j.bmcl.2016.06.014
11082446 9909 None 0 Pig Binding pIC50 = 10.8 10.8 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 581 12 1 11 4.6 COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2Oc2cccc(OC)c2)nc1 10.1021/jm0102304
CHEMBL114380 9909 None 0 Pig Binding pIC50 = 10.8 10.8 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 581 12 1 11 4.6 COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2Oc2cccc(OC)c2)nc1 10.1021/jm0102304
10897569 10138 None 0 Pig Binding pIC50 = 10.7 10.7 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 645 11 1 10 5.7 COc1ccccc1Sc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCOc1ncc(Br)cn1 10.1021/jm0102304
CHEMBL115724 10138 None 0 Pig Binding pIC50 = 10.7 10.7 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 645 11 1 10 5.7 COc1ccccc1Sc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCOc1ncc(Br)cn1 10.1021/jm0102304
10227760 100985 None 0 Human Binding pIC50 = 10.7 10.7 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 481 6 2 7 4.9 CC(=O)c1c(C)c(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL294291 100985 None 0 Human Binding pIC50 = 10.7 10.7 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 481 6 2 7 4.9 CC(=O)c1c(C)c(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
10163017 200779 None 0 Human Binding pIC50 = 10.7 10.7 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 482 6 3 8 4.6 C/C(=N\O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL60058 200779 None 0 Human Binding pIC50 = 10.7 10.7 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 482 6 3 8 4.6 C/C(=N\O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
44284236 122321 None 0 Human Binding pIC50 = 10.7 10.7 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 504 9 3 7 4.5 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCCO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL35984 122321 None 0 Human Binding pIC50 = 10.7 10.7 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 504 9 3 7 4.5 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCCO)c1 10.1016/j.bmcl.2004.01.008
72548703 161565 None 0 Human Binding pIC50 = 10.6 10.6 - 0
Displacement of [125I]-endothelin-1 from human recombinant ETA receptor after 120 mins by scintillation counting analysisDisplacement of [125I]-endothelin-1 from human recombinant ETA receptor after 120 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
CHEMBL4128926 161565 None 0 Human Binding pIC50 = 10.6 10.6 - 0
Displacement of [125I]-endothelin-1 from human recombinant ETA receptor after 120 mins by scintillation counting analysisDisplacement of [125I]-endothelin-1 from human recombinant ETA receptor after 120 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
101598716 1560 None 30 Human Binding pIC50 = 10.6 10.6 - 0
Displacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cellsDisplacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
16133807 1560 None 30 Human Binding pIC50 = 10.6 10.6 - 0
Displacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cellsDisplacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
16212950 1560 None 30 Human Binding pIC50 = 10.6 10.6 - 0
Displacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cellsDisplacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
989 1560 None 30 Human Binding pIC50 = 10.6 10.6 - 0
Displacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cellsDisplacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
CHEMBL3775234 1560 None 30 Human Binding pIC50 = 10.6 10.6 - 0
Displacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cellsDisplacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
101598716 1560 None 30 Human Binding pIC50 = 10.6 10.6 - 0
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
16133807 1560 None 30 Human Binding pIC50 = 10.6 10.6 - 0
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
16212950 1560 None 30 Human Binding pIC50 = 10.6 10.6 - 0
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
989 1560 None 30 Human Binding pIC50 = 10.6 10.6 - 0
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
CHEMBL3775234 1560 None 30 Human Binding pIC50 = 10.6 10.6 - 0
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
44284288 100133 None 0 Human Binding pIC50 = 10.6 10.6 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 559 9 2 7 4.9 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 10.1016/j.bmcl.2004.01.008
CHEMBL287683 100133 None 0 Human Binding pIC50 = 10.6 10.6 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 559 9 2 7 4.9 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 10.1016/j.bmcl.2004.01.008
44284405 100354 None 0 Human Binding pIC50 = 10.6 10.6 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 2 7 5.4 COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
CHEMBL289634 100354 None 0 Human Binding pIC50 = 10.6 10.6 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 2 7 5.4 COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
9873636 173822 None 0 Rat Binding pIC50 = 10.6 10.6 - 0
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 607 10 1 10 6.4 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2cc3ccccc3s2)nc1 10.1016/j.bmcl.2016.06.014
CHEMBL4538570 173822 None 0 Rat Binding pIC50 = 10.6 10.6 - 0
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 607 10 1 10 6.4 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2cc3ccccc3s2)nc1 10.1016/j.bmcl.2016.06.014
44381151 59387 None 0 Pig Binding pIC50 = 10.6 10.6 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 671 13 1 10 6.3 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 10.1016/s0960-894x(01)00682-5
CHEMBL170908 59387 None 0 Pig Binding pIC50 = 10.6 10.6 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 671 13 1 10 6.3 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 10.1016/s0960-894x(01)00682-5
44284266 136930 None 0 Human Binding pIC50 = 10.6 10.6 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 531 8 2 7 4.6 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CN(C)C(C)=O)c1 10.1016/j.bmcl.2004.01.008
CHEMBL37427 136930 None 0 Human Binding pIC50 = 10.6 10.6 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 531 8 2 7 4.6 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CN(C)C(C)=O)c1 10.1016/j.bmcl.2004.01.008
11039156 10068 None 0 Pig Binding pIC50 = 10.6 10.6 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 581 11 1 10 5.2 COc1cccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(SC)cn2)c1 10.1021/jm0102304
CHEMBL115333 10068 None 0 Pig Binding pIC50 = 10.6 10.6 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 581 11 1 10 5.2 COc1cccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(SC)cn2)c1 10.1021/jm0102304
10206855 100900 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 493 7 2 7 5.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C2CC2)c1 10.1021/jm030528p
CHEMBL293830 100900 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 493 7 2 7 5.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C2CC2)c1 10.1021/jm030528p
10185556 102654 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 503 6 2 8 3.8 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(S(C)(=O)=O)c1 10.1021/jm030528p
CHEMBL304460 102654 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 503 6 2 8 3.8 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(S(C)(=O)=O)c1 10.1021/jm030528p
10228523 201228 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 495 7 2 7 5.3 CCC(=O)c1c(C)c(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL60367 201228 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 495 7 2 7 5.3 CCC(=O)c1c(C)c(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
44284238 100125 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 490 8 3 7 4.2 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL287622 100125 None 0 Human Binding pIC50 = 10.5 10.5 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 490 8 3 7 4.2 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCO)c1 10.1016/j.bmcl.2004.01.008
10152810 14784 None 2 Rat Binding pIC50 = 10.5 10.5 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 538 10 1 9 4.8 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1F 10.1016/s0960-894x(98)00301-1
CHEMBL1206706 14784 None 2 Rat Binding pIC50 = 10.5 10.5 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 538 10 1 9 4.8 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1F 10.1016/s0960-894x(98)00301-1
CHEMBL298725 14784 None 2 Rat Binding pIC50 = 10.5 10.5 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 538 10 1 9 4.8 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1F 10.1016/s0960-894x(98)00301-1
159594 522 None 45 Human Binding pIC50 = 10.5 10.5 1 3
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm970101g
3487 522 None 45 Human Binding pIC50 = 10.5 10.5 1 3
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm970101g
CHEMBL9194 522 None 45 Human Binding pIC50 = 10.5 10.5 1 3
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm970101g
DB06199 522 None 45 Human Binding pIC50 = 10.5 10.5 1 3
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm970101g
10962637 10077 None 0 Rat Binding pIC50 = 10.5 10.5 - 0
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 549 10 2 9 4.3 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(CO)cn2)cc1 10.1021/jm000538f
CHEMBL115372 10077 None 0 Rat Binding pIC50 = 10.5 10.5 - 0
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 549 10 2 9 4.3 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(CO)cn2)cc1 10.1021/jm000538f
CHEMBL1627023 10077 None 0 Rat Binding pIC50 = 10.5 10.5 - 0
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 549 10 2 9 4.3 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(CO)cn2)cc1 10.1021/jm000538f
159594 522 None 45 Human Binding pIC50 = 10.5 10.5 1 3
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990171i
3487 522 None 45 Human Binding pIC50 = 10.5 10.5 1 3
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990171i
CHEMBL9194 522 None 45 Human Binding pIC50 = 10.5 10.5 1 3
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990171i
DB06199 522 None 45 Human Binding pIC50 = 10.5 10.5 1 3
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990171i
11767155 11739 None 0 Pig Binding pIC50 = 10.4 10.4 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 596 10 1 9 5.9 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccccn3)cn2)cc1 10.1021/jm0102304
CHEMBL1181545 11739 None 0 Pig Binding pIC50 = 10.4 10.4 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 596 10 1 9 5.9 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccccn3)cn2)cc1 10.1021/jm0102304
CHEMBL177173 11739 None 0 Pig Binding pIC50 = 10.4 10.4 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 596 10 1 9 5.9 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccccn3)cn2)cc1 10.1021/jm0102304
44284041 100301 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 3 8 4.4 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL289216 100301 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 3 8 4.4 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 10.1016/j.bmcl.2004.01.008
9938571 9595 None 0 Rat Binding pIC50 = 10.4 10.4 - 1
Ability to inhibit specific binding of [125I]- -ET-1 to rat A 10 cells which express endothelin A receptorAbility to inhibit specific binding of [125I]- -ET-1 to rat A 10 cells which express endothelin A receptor
ChEMBL 597 9 1 8 5.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
CHEMBL112531 9595 None 0 Rat Binding pIC50 = 10.4 10.4 - 1
Ability to inhibit specific binding of [125I]- -ET-1 to rat A 10 cells which express endothelin A receptorAbility to inhibit specific binding of [125I]- -ET-1 to rat A 10 cells which express endothelin A receptor
ChEMBL 597 9 1 8 5.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
CHEMBL369489 9595 None 0 Rat Binding pIC50 = 10.4 10.4 - 1
Ability to inhibit specific binding of [125I]- -ET-1 to rat A 10 cells which express endothelin A receptorAbility to inhibit specific binding of [125I]- -ET-1 to rat A 10 cells which express endothelin A receptor
ChEMBL 597 9 1 8 5.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
9938571 9595 None 0 Rat Binding pIC50 = 10.4 10.4 - 1
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 597 9 1 8 5.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL112531 9595 None 0 Rat Binding pIC50 = 10.4 10.4 - 1
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 597 9 1 8 5.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL369489 9595 None 0 Rat Binding pIC50 = 10.4 10.4 - 1
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 597 9 1 8 5.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
10187997 109970 None 0 Rat Binding pIC50 = 10.4 10.4 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm031041j
CHEMBL323464 109970 None 0 Rat Binding pIC50 = 10.4 10.4 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm031041j
11828009 9889 None 0 Pig Binding pIC50 = 10.4 10.4 - 0
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 581 11 2 10 4.7 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(CO)cc2)nc1 10.1021/jm000538f
CHEMBL114298 9889 None 0 Pig Binding pIC50 = 10.4 10.4 - 0
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 581 11 2 10 4.7 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(CO)cc2)nc1 10.1021/jm000538f
11966523 110368 None 0 Pig Binding pIC50 = 10.4 10.4 - 0
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 613 10 2 9 4.7 CC(C)(C)c1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(CO)cc2)cc1 10.1021/jm000538f
CHEMBL324184 110368 None 0 Pig Binding pIC50 = 10.4 10.4 - 0
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 613 10 2 9 4.7 CC(C)(C)c1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(CO)cc2)cc1 10.1021/jm000538f
9934302 72642 None 1 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 467 6 2 7 4.6 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL19950 72642 None 1 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 467 6 2 7 4.6 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
11752337 162226 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 496 7 2 8 4.7 CO/N=C(\C)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL416324 162226 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 496 7 2 8 4.7 CO/N=C(\C)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
23445355 200900 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 469 6 2 8 3.8 COC(=O)c1cc(C)ccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL60149 200900 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 469 6 2 8 3.8 COC(=O)c1cc(C)ccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
9934302 72642 None 1 Human Binding pIC50 = 10.4 10.4 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 467 6 2 7 4.6 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm000349x
CHEMBL19950 72642 None 1 Human Binding pIC50 = 10.4 10.4 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 467 6 2 7 4.6 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm000349x
44284115 100193 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 9 3 7 4.8 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL288247 100193 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 9 3 7 4.8 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 10.1016/j.bmcl.2004.01.008
44381125 59287 None 0 Pig Binding pIC50 = 10.4 10.4 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 674 10 1 9 6.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(-c3ccccn3)nc2OCCOc2ncc(Br)cn2)cc1 10.1016/s0960-894x(01)00682-5
CHEMBL170493 59287 None 0 Pig Binding pIC50 = 10.4 10.4 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 674 10 1 9 6.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(-c3ccccn3)nc2OCCOc2ncc(Br)cn2)cc1 10.1016/s0960-894x(01)00682-5
10187997 109970 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL323464 109970 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
44284287 161245 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 3 7 5.2 CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
CHEMBL411925 161245 None 0 Human Binding pIC50 = 10.4 10.4 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 3 7 5.2 CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
44284481 213723 None 0 Human Binding pIC50 = 10.3 10.3 -4 5
Inhibition of ETA receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of ETA receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/np900287e
CHEMBL437472 213723 None 0 Human Binding pIC50 = 10.3 10.3 -4 5
Inhibition of ETA receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of ETA receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/np900287e
44284328 127539 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 476 7 2 7 4.6 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC)c1 10.1016/j.bmcl.2004.01.008
CHEMBL36627 127539 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 476 7 2 7 4.6 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC)c1 10.1016/j.bmcl.2004.01.008
44284437 99982 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 4 8 3.5 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL286621 99982 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 4 8 3.5 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 10.1016/j.bmcl.2004.01.008
44386450 62396 None 0 Rat Binding pIC50 = 10.3 10.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 606 15 1 10 5.1 COC(=O)CCCCOc1cc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc(OC)c1OC 10.1021/jm031041j
CHEMBL177973 62396 None 0 Rat Binding pIC50 = 10.3 10.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 606 15 1 10 5.1 COC(=O)CCCCOc1cc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc(OC)c1OC 10.1021/jm031041j
44284481 213723 None 0 Human Binding pIC50 = 10.3 10.3 -4 5
Binding affinity to human ETA receptor by radioligand displacement assayBinding affinity to human ETA receptor by radioligand displacement assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/j.ejmech.2013.01.044
CHEMBL437472 213723 None 0 Human Binding pIC50 = 10.3 10.3 -4 5
Binding affinity to human ETA receptor by radioligand displacement assayBinding affinity to human ETA receptor by radioligand displacement assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/j.ejmech.2013.01.044
10143256 100572 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 531 7 2 8 4.6 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(S(=O)(=O)C(C)C)c1 10.1021/jm030528p
CHEMBL291592 100572 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 531 7 2 8 4.6 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(S(=O)(=O)C(C)C)c1 10.1021/jm030528p
10183338 202784 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 464 5 2 7 4.5 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C#N)c1C 10.1021/jm030528p
CHEMBL62159 202784 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 464 5 2 7 4.5 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C#N)c1C 10.1021/jm030528p
10722385 100497 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 606 13 1 11 4.6 COC(=O)CCCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC 10.1021/jm980504w
CHEMBL291058 100497 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 606 13 1 11 4.6 COC(=O)CCCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC 10.1021/jm980504w
11006709 9955 None 0 Pig Binding pIC50 = 10.3 10.3 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membraneIn vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane
ChEMBL 629 11 1 10 5.4 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1016/s0960-894x(01)00682-5
CHEMBL114700 9955 None 0 Pig Binding pIC50 = 10.3 10.3 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membraneIn vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane
ChEMBL 629 11 1 10 5.4 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1016/s0960-894x(01)00682-5
11006709 9955 None 0 Pig Binding pIC50 = 10.3 10.3 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 629 11 1 10 5.4 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1021/jm0102304
CHEMBL114700 9955 None 0 Pig Binding pIC50 = 10.3 10.3 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 629 11 1 10 5.4 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1021/jm0102304
10651488 163377 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
CHEMBL419367 163377 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
159594 522 None 45 Human Binding pIC50 = 10.3 10.3 1 3
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
3487 522 None 45 Human Binding pIC50 = 10.3 10.3 1 3
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
CHEMBL9194 522 None 45 Human Binding pIC50 = 10.3 10.3 1 3
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
DB06199 522 None 45 Human Binding pIC50 = 10.3 10.3 1 3
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
44284041 100301 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 3 8 4.4 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL289216 100301 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 3 8 4.4 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 10.1016/j.bmcl.2004.01.008
11734600 10008 None 0 Pig Binding pIC50 = 10.2 10.2 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 585 11 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)c1 10.1021/jm0102304
CHEMBL114964 10008 None 0 Pig Binding pIC50 = 10.2 10.2 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 585 11 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)c1 10.1021/jm0102304
44284115 100193 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 9 3 7 4.8 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL288247 100193 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 9 3 7 4.8 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 10.1016/j.bmcl.2004.01.008
10119327 202754 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 531 8 2 8 4.6 CCCS(=O)(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL62019 202754 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 531 8 2 8 4.6 CCCS(=O)(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
10206155 202774 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 481 7 2 7 5.0 CCC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL62112 202774 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 481 7 2 7 5.0 CCC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
10344914 100135 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 476 7 3 7 4.1 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL287711 100135 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 476 7 3 7 4.1 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CO)c1 10.1016/j.bmcl.2004.01.008
44284391 139299 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 9 3 7 5.3 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCC(C)(C)O)c1 10.1016/j.bmcl.2004.01.008
CHEMBL37920 139299 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 9 3 7 5.3 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCC(C)(C)O)c1 10.1016/j.bmcl.2004.01.008
10119177 117463 None 0 Rat Binding pIC50 = 10.2 10.2 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 528 12 1 6 4.8 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm010237l
CHEMBL339904 117463 None 0 Rat Binding pIC50 = 10.2 10.2 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 528 12 1 6 4.8 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm010237l
10603409 110602 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
CHEMBL325581 110602 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
10228588 101856 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 496 6 2 7 4.1 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)N(C)C)c1 10.1021/jm030528p
CHEMBL300577 101856 None 0 Human Binding pIC50 = 10.2 10.2 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 496 6 2 7 4.1 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)N(C)C)c1 10.1021/jm030528p
10210629 8762 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL109644 8762 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
9916235 9351 None 1 Human Binding pIC50 = 10.1 10.1 - 0
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL111277 9351 None 1 Human Binding pIC50 = 10.1 10.1 - 0
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
159594 522 None 45 Human Binding pIC50 = 10.1 10.1 1 3
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990170q
3487 522 None 45 Human Binding pIC50 = 10.1 10.1 1 3
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990170q
CHEMBL9194 522 None 45 Human Binding pIC50 = 10.1 10.1 1 3
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990170q
DB06199 522 None 45 Human Binding pIC50 = 10.1 10.1 1 3
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990170q
9916235 9351 None 1 Human Binding pIC50 = 10.1 10.1 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm990170q
CHEMBL111277 9351 None 1 Human Binding pIC50 = 10.1 10.1 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm990170q
10278217 101768 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 492 6 2 8 5.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(-c2ncco2)c1 10.1021/jm030528p
CHEMBL299921 101768 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 492 6 2 8 5.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(-c2ncco2)c1 10.1021/jm030528p
9911482 168071 None 20 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 447 6 2 7 4.2 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm030528p
CHEMBL432521 168071 None 20 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 447 6 2 7 4.2 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm030528p
10114414 198820 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 444 5 2 7 4.2 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C#N)c1C 10.1021/jm030528p
CHEMBL58359 198820 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 444 5 2 7 4.2 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C#N)c1C 10.1021/jm030528p
11766844 109779 None 0 Rat Binding pIC50 = 10.1 10.1 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 553 9 1 8 5.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)cc1 10.1021/jm0102304
CHEMBL176272 109779 None 0 Rat Binding pIC50 = 10.1 10.1 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 553 9 1 8 5.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)cc1 10.1021/jm0102304
CHEMBL323243 109779 None 0 Rat Binding pIC50 = 10.1 10.1 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 553 9 1 8 5.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)cc1 10.1021/jm0102304
159594 522 None 45 Rat Binding pIC50 = 10.1 10.1 -1 3
Inhibitory activity against human Endothelin A receptorInhibitory activity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
3487 522 None 45 Rat Binding pIC50 = 10.1 10.1 -1 3
Inhibitory activity against human Endothelin A receptorInhibitory activity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
CHEMBL9194 522 None 45 Rat Binding pIC50 = 10.1 10.1 -1 3
Inhibitory activity against human Endothelin A receptorInhibitory activity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
DB06199 522 None 45 Rat Binding pIC50 = 10.1 10.1 -1 3
Inhibitory activity against human Endothelin A receptorInhibitory activity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
10115469 100836 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 459 5 2 6 5.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(Cl)c1 10.1021/jm030528p
CHEMBL293398 100836 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 459 5 2 6 5.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(Cl)c1 10.1021/jm030528p
10627272 204054 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 592 12 1 11 4.2 COC(=O)CCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC 10.1021/jm980504w
CHEMBL69986 204054 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 592 12 1 11 4.2 COC(=O)CCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC 10.1021/jm980504w
10603409 110602 None 0 Rat Binding pIC50 = 10.0 10.0 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
CHEMBL325581 110602 None 0 Rat Binding pIC50 = 10.0 10.0 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
10187997 109970 None 0 Rat Binding pIC50 = 10 10.0 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL323464 109970 None 0 Rat Binding pIC50 = 10 10.0 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
21041278 171775 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 554 12 2 9 3.5 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4467748 171775 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 554 12 2 9 3.5 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
10165963 102847 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 545 8 2 9 3.6 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)CS(C)(=O)=O)c1 10.1021/jm030528p
CHEMBL305602 102847 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 545 8 2 9 3.6 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)CS(C)(=O)=O)c1 10.1021/jm030528p
10366278 172462 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 446 6 2 6 4.6 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL448165 172462 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 446 6 2 6 4.6 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
10624511 71736 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 478 6 2 7 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2noc(C)c2Cl)c(C)c1CC#N 10.1021/jm000349x
CHEMBL19661 71736 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 478 6 2 7 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2noc(C)c2Cl)c(C)c1CC#N 10.1021/jm000349x
10210629 8762 None 0 Rat Binding pIC50 = 10.0 10.0 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL109644 8762 None 0 Rat Binding pIC50 = 10.0 10.0 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
11827657 19379 None 1 Rat Binding pIC50 = 10.0 10.0 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 540 13 1 7 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 10.1021/jm010237l
CHEMBL129220 19379 None 1 Rat Binding pIC50 = 10.0 10.0 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 540 13 1 7 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 10.1021/jm010237l
44284481 213723 None 0 Human Binding pIC50 = 10.0 10.0 -4 5
Binding affinity to human ETA receptor by radioligand displacement assayBinding affinity to human ETA receptor by radioligand displacement assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/j.bmc.2013.03.016
CHEMBL437472 213723 None 0 Human Binding pIC50 = 10.0 10.0 -4 5
Binding affinity to human ETA receptor by radioligand displacement assayBinding affinity to human ETA receptor by radioligand displacement assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/j.bmc.2013.03.016
44302615 200422 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 497 7 2 8 4.6 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)OC(C)C)c1 10.1021/jm030528p
CHEMBL59819 200422 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 497 7 2 8 4.6 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)OC(C)C)c1 10.1021/jm030528p
25211074 18483 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 543 10 2 7 5.1 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1272244 18483 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 543 10 2 7 5.1 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
11016761 109021 None 0 Pig Binding pIC50 = 10.0 10.0 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 519 9 1 8 4.8 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncccn2)cc1 10.1021/jm0102304
CHEMBL321242 109021 None 0 Pig Binding pIC50 = 10.0 10.0 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 519 9 1 8 4.8 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncccn2)cc1 10.1021/jm0102304
44284329 100410 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 504 8 2 7 5.4 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)C)c1 10.1016/j.bmcl.2004.01.008
CHEMBL290181 100410 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 504 8 2 7 5.4 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)C)c1 10.1016/j.bmcl.2004.01.008
9914310 206641 None 8 Human Binding pIC50 = 10.0 10.0 1995 2
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL8923 206641 None 8 Human Binding pIC50 = 10.0 10.0 1995 2
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
10768977 61846 None 0 Rat Binding pIC50 = 9.9 9.9 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 548 13 1 8 5.6 CCOc1cc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc(OCC)c1OCC 10.1021/jm031041j
CHEMBL177378 61846 None 0 Rat Binding pIC50 = 9.9 9.9 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 548 13 1 8 5.6 CCOc1cc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc(OCC)c1OCC 10.1021/jm031041j
44352079 116539 None 0 Rat Binding pIC50 = 9.9 9.9 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 494 11 1 5 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 10.1021/jm010237l
CHEMBL336272 116539 None 0 Rat Binding pIC50 = 9.9 9.9 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 494 11 1 5 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 10.1021/jm010237l
10674176 162698 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 548 11 1 9 5.0 CCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OCC)c1OCC 10.1021/jm9606507
CHEMBL417067 162698 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 548 11 1 9 5.0 CCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OCC)c1OCC 10.1021/jm9606507
44334146 167998 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 446 7 2 6 4.6 CCCNc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL432012 167998 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 446 7 2 6 4.6 CCCNc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
10163744 98712 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 495 7 2 7 5.2 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C(C)C)c1 10.1021/jm000349x
CHEMBL277706 98712 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 495 7 2 7 5.2 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C(C)C)c1 10.1021/jm000349x
9916235 9351 None 1 Rat Binding pIC50 = 9.9 9.9 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL111277 9351 None 1 Rat Binding pIC50 = 9.9 9.9 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
11465535 201069 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 468 6 3 7 3.5 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(N)=O)c1 10.1021/jm030528p
CHEMBL60276 201069 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 468 6 3 7 3.5 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(N)=O)c1 10.1021/jm030528p
10277399 66864 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 478 6 2 7 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1CC#N 10.1021/jm000349x
CHEMBL18626 66864 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 478 6 2 7 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1CC#N 10.1021/jm000349x
10139080 72565 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 454 6 2 7 4.6 Cc1cc(C)c(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1O 10.1021/jm000349x
CHEMBL19921 72565 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 454 6 2 7 4.6 Cc1cc(C)c(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1O 10.1021/jm000349x
10717923 98691 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 439 5 2 6 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm030528p
CHEMBL277595 98691 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 439 5 2 6 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm030528p
9810351 58079 None 0 Pig Binding pIC50 = 9.8 9.8 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 705 14 2 12 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(SCCO)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
CHEMBL167314 58079 None 0 Pig Binding pIC50 = 9.8 9.8 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 705 14 2 12 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(SCCO)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
44284481 213723 None 0 Pig Binding pIC50 = 9.8 9.8 -3 5
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00077a013
CHEMBL437472 213723 None 0 Pig Binding pIC50 = 9.8 9.8 -3 5
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00077a013
9936145 19025 None 2 Human Binding pIC50 = 9.8 9.8 - 1
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 510 11 1 4 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 10.1021/jm010237l
CHEMBL128818 19025 None 2 Human Binding pIC50 = 9.8 9.8 - 1
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 510 11 1 4 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 10.1021/jm010237l
44284481 213723 None 0 Human Binding pIC50 = 9.8 9.8 -4 5
Displacement of radiolabeled endothelin-1 from human endothelin ETA receptorDisplacement of radiolabeled endothelin-1 from human endothelin ETA receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm8007618
CHEMBL437472 213723 None 0 Human Binding pIC50 = 9.8 9.8 -4 5
Displacement of radiolabeled endothelin-1 from human endothelin ETA receptorDisplacement of radiolabeled endothelin-1 from human endothelin ETA receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm8007618
11731472 9510 None 0 Pig Binding pIC50 = 9.8 9.8 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 571 10 1 10 5.6 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)s2)nc1 10.1021/jm0102304
CHEMBL112141 9510 None 0 Pig Binding pIC50 = 9.8 9.8 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 571 10 1 10 5.6 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)s2)nc1 10.1021/jm0102304
11050163 11742 None 0 Pig Binding pIC50 = 9.8 9.8 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 583 10 1 8 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL1181553 11742 None 0 Pig Binding pIC50 = 9.8 9.8 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 583 10 1 8 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL177924 11742 None 0 Pig Binding pIC50 = 9.8 9.8 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 583 10 1 8 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
44351968 118078 None 0 Rat Binding pIC50 = 9.8 9.8 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 508 12 1 5 5.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 10.1021/jm010237l
CHEMBL340575 118078 None 0 Rat Binding pIC50 = 9.8 9.8 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 508 12 1 5 5.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 10.1021/jm010237l
10717923 98691 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 439 5 2 6 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm000349x
CHEMBL277595 98691 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 439 5 2 6 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm000349x
10623757 98929 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 458 6 2 7 4.4 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1CC#N 10.1021/jm000349x
CHEMBL279471 98929 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 458 6 2 7 4.4 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1CC#N 10.1021/jm000349x
9806559 9148 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 515 13 1 6 3.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O 10.1021/jm980217s
CHEMBL110053 9148 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 515 13 1 6 3.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O 10.1021/jm980217s
9936145 19025 None 2 Human Binding pIC50 = 9.7 9.7 - 1
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 510 11 1 4 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 10.1021/jm010237l
CHEMBL128818 19025 None 2 Human Binding pIC50 = 9.7 9.7 - 1
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 510 11 1 4 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 10.1021/jm010237l
CHEMBL1790959 208906 None 0 Pig Binding pIC50 = 9.7 9.7 - 0
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
9825494 202608 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
CHEMBL61211 202608 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
9825494 202608 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL61211 202608 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
9825494 202608 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]ET-1 from ET-A receptor in RASMC incubated for 60 minsDisplacement of [125I]ET-1 from ET-A receptor in RASMC incubated for 60 mins
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/acs.jmedchem.5b01781
CHEMBL61211 202608 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]ET-1 from ET-A receptor in RASMC incubated for 60 minsDisplacement of [125I]ET-1 from ET-A receptor in RASMC incubated for 60 mins
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/acs.jmedchem.5b01781
9868637 99086 None 1 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 455 5 3 7 4.4 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1O 10.1021/jm000349x
CHEMBL280659 99086 None 1 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 455 5 3 7 4.4 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1O 10.1021/jm000349x
CHEMBL1790963 208909 None 0 Pig Binding pIC50 = 9.7 9.7 - 0
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
11757759 174444 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 570 13 2 10 2.8 COCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4553625 174444 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 570 13 2 10 2.8 COCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
18931096 58745 None 0 Pig Binding pIC50 = 9.7 9.7 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 689 14 2 12 4.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(OCCO)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
CHEMBL168604 58745 None 0 Pig Binding pIC50 = 9.7 9.7 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 689 14 2 12 4.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(OCCO)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
44284481 213723 None 0 Human Binding pIC50 = 9.7 9.7 -4 5
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
CHEMBL437472 213723 None 0 Human Binding pIC50 = 9.7 9.7 -4 5
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
10722371 102226 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 605 11 1 11 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCN3CCOCC3)c2)cc1 10.1021/jm980504w
CHEMBL302974 102226 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 605 11 1 11 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCN3CCOCC3)c2)cc1 10.1021/jm980504w
10578853 103590 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 564 10 1 11 3.4 COC(=O)COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC 10.1021/jm980504w
CHEMBL308646 103590 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 564 10 1 11 3.4 COC(=O)COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC 10.1021/jm980504w
44334128 4404 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 443 7 1 5 4.9 C=CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL101424 4404 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 443 7 1 5 4.9 C=CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
9939238 204126 None 0 Human Binding pIC50 = 9.7 9.7 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 637 12 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70385 204126 None 0 Human Binding pIC50 = 9.7 9.7 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 637 12 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44284481 213723 None 0 Human Binding pIC50 = 9.7 9.7 -4 5
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(97)00400-9
CHEMBL437472 213723 None 0 Human Binding pIC50 = 9.7 9.7 -4 5
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(97)00400-9
CHEMBL1790960 208907 None 0 Pig Binding pIC50 = 9.7 9.7 - 0
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL None None None CCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00077a013
10120499 109754 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 564 12 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CC(C)C 10.1021/jm970101g
CHEMBL323055 109754 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 564 12 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CC(C)C 10.1021/jm970101g
11113541 203266 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 7 1 7 5.2 COc1ccc(OC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL64632 203266 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 7 1 7 5.2 COc1ccc(OC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
10299555 101031 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 481 6 2 7 4.9 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sc(C)cc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL294563 101031 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 481 6 2 7 4.9 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sc(C)cc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
10321290 4634 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 445 7 1 5 5.1 CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL102969 4634 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 445 7 1 5 5.1 CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
10651488 163377 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
CHEMBL419367 163377 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
44284381 128507 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 462 6 3 7 4.3 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(O)c1 10.1016/j.bmcl.2004.01.008
CHEMBL36671 128507 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 462 6 3 7 4.3 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(O)c1 10.1016/j.bmcl.2004.01.008
10648937 207304 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 11 1 6 4.3 CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9334 207304 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 11 1 6 4.3 CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
44284481 213723 None 0 Human Binding pIC50 = 9.6 9.6 -4 5
Displacement of [125I]Endothelin-1 from human recombinant ETA receptor expressed in CHOK1 cells after 2 hrsDisplacement of [125I]Endothelin-1 from human recombinant ETA receptor expressed in CHOK1 cells after 2 hrs
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/j.bmcl.2013.01.025
CHEMBL437472 213723 None 0 Human Binding pIC50 = 9.6 9.6 -4 5
Displacement of [125I]Endothelin-1 from human recombinant ETA receptor expressed in CHOK1 cells after 2 hrsDisplacement of [125I]Endothelin-1 from human recombinant ETA receptor expressed in CHOK1 cells after 2 hrs
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/j.bmcl.2013.01.025
123883 14642 None 1 Human Binding pIC50 = 9.6 9.6 - 0
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm970101g
CHEMBL1205177 14642 None 1 Human Binding pIC50 = 9.6 9.6 - 0
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm970101g
CHEMBL61425 14642 None 1 Human Binding pIC50 = 9.6 9.6 - 0
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm970101g
123883 14642 None 1 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm030528p
CHEMBL1205177 14642 None 1 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm030528p
CHEMBL61425 14642 None 1 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm030528p
11006532 12241 None 0 Rat Binding pIC50 = 9.6 9.6 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 10 1 9 6.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3cccs3)cn2)cc1 10.1021/jm0102304
CHEMBL1184515 12241 None 0 Rat Binding pIC50 = 9.6 9.6 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 10 1 9 6.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3cccs3)cn2)cc1 10.1021/jm0102304
CHEMBL367445 12241 None 0 Rat Binding pIC50 = 9.6 9.6 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 10 1 9 6.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3cccs3)cn2)cc1 10.1021/jm0102304
9894460 206707 None 9 Human Binding pIC50 = 9.6 9.6 24 3
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm970101g
CHEMBL313871 206707 None 9 Human Binding pIC50 = 9.6 9.6 24 3
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm970101g
CHEMBL8978 206707 None 9 Human Binding pIC50 = 9.6 9.6 24 3
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm970101g
22004774 100807 None 0 Rat Binding pIC50 = 9.6 9.6 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 442 8 1 6 5.7 CCCCSC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL293192 100807 None 0 Rat Binding pIC50 = 9.6 9.6 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 442 8 1 6 5.7 CCCCSC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL2304284 209486 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of ETA receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of ETA receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/np900287e
44387242 120401 None 0 Rat Binding pIC50 = 9.5 9.5 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 502 15 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCCC(C)C 10.1021/jm031041j
CHEMBL353560 120401 None 0 Rat Binding pIC50 = 9.5 9.5 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 502 15 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCCC(C)C 10.1021/jm031041j
11093237 10405 None 0 Pig Binding pIC50 = 9.5 9.5 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 10 1 9 6.4 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc3ccccc3c2)nc1 10.1021/jm0102304
CHEMBL116281 10405 None 0 Pig Binding pIC50 = 9.5 9.5 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 10 1 9 6.4 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc3ccccc3c2)nc1 10.1021/jm0102304
10769526 102698 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 578 12 2 10 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCC(=O)O)c2)cc1 10.1021/jm980504w
CHEMBL304762 102698 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 578 12 2 10 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCC(=O)O)c2)cc1 10.1021/jm980504w
9870959 8915 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 509 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 10.1021/jm980217s
CHEMBL109778 8915 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 509 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 10.1021/jm980217s
44339655 9104 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 530 14 1 6 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL109926 9104 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 530 14 1 6 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
10278777 168130 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 502 14 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
CHEMBL432974 168130 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 502 14 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
9870830 206712 None 38 Human Binding pIC50 = 9.5 9.5 66 2
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
CHEMBL8981 206712 None 38 Human Binding pIC50 = 9.5 9.5 66 2
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
9939238 204126 None 0 Human Binding pIC50 = 9.5 9.5 - 1
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 637 12 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
CHEMBL70385 204126 None 0 Human Binding pIC50 = 9.5 9.5 - 1
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 637 12 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
21041284 170935 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 568 13 2 9 3.9 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4455360 170935 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 568 13 2 9 3.9 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
58688006 171114 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 524 13 2 9 3.8 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4458005 171114 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 524 13 2 9 3.8 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
9870830 206712 None 38 Mouse Binding pIC50 = 9.5 9.5 - 2
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/j.bmc.2009.08.058
CHEMBL8981 206712 None 38 Mouse Binding pIC50 = 9.5 9.5 - 2
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/j.bmc.2009.08.058
21041264 82009 None 1 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 600 12 2 8 4.0 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
CHEMBL2165339 82009 None 1 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 600 12 2 8 4.0 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
10311570 14628 None 0 Rat Binding pIC50 = 9.5 9.5 - 1
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 520 10 1 9 4.7 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1205068 14628 None 0 Rat Binding pIC50 = 9.5 9.5 - 1
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 520 10 1 9 4.7 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL48907 14628 None 0 Rat Binding pIC50 = 9.5 9.5 - 1
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 520 10 1 9 4.7 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
10555424 204034 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 592 13 2 10 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCCC(=O)O)c2)cc1 10.1021/jm980504w
CHEMBL69832 204034 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 592 13 2 10 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCCC(=O)O)c2)cc1 10.1021/jm980504w
9870830 206712 None 38 Human Binding pIC50 = 9.5 9.5 66 2
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm980504w
CHEMBL8981 206712 None 38 Human Binding pIC50 = 9.5 9.5 66 2
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm980504w
9871348 204025 None 0 Rat Binding pIC50 = 9.5 9.5 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 520 8 1 10 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4nsnc4c3)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/s0960-894x(97)10151-2
CHEMBL69741 204025 None 0 Rat Binding pIC50 = 9.5 9.5 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 520 8 1 10 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4nsnc4c3)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/s0960-894x(97)10151-2
9809919 204407 None 0 Human Binding pIC50 = 9.5 9.5 - 2
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 665 13 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL72037 204407 None 0 Human Binding pIC50 = 9.5 9.5 - 2
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 665 13 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44284481 213723 None 0 Human Binding pIC50 = 9.5 9.5 -4 5
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(97)00400-9
CHEMBL437472 213723 None 0 Human Binding pIC50 = 9.5 9.5 -4 5
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(97)00400-9
159594 522 None 45 Rat Binding pIC50 = 9.5 9.5 -1 3
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm031041j
3487 522 None 45 Rat Binding pIC50 = 9.5 9.5 -1 3
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm031041j
CHEMBL9194 522 None 45 Rat Binding pIC50 = 9.5 9.5 -1 3
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm031041j
DB06199 522 None 45 Rat Binding pIC50 = 9.5 9.5 -1 3
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm031041j
159594 522 None 45 Human Binding pIC50 = 9.5 9.5 1 3
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
3487 522 None 45 Human Binding pIC50 = 9.5 9.5 1 3
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
CHEMBL9194 522 None 45 Human Binding pIC50 = 9.5 9.5 1 3
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
DB06199 522 None 45 Human Binding pIC50 = 9.5 9.5 1 3
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
159594 522 None 45 Rat Binding pIC50 = 9.5 9.5 -1 3
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
3487 522 None 45 Rat Binding pIC50 = 9.5 9.5 -1 3
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
CHEMBL9194 522 None 45 Rat Binding pIC50 = 9.5 9.5 -1 3
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
DB06199 522 None 45 Rat Binding pIC50 = 9.5 9.5 -1 3
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
11144344 203010 None 0 Rat Binding pIC50 = 9.5 9.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 424 8 1 5 5.8 CCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL63267 203010 None 0 Rat Binding pIC50 = 9.5 9.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 424 8 1 5 5.8 CCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
44334150 4532 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 445 6 1 5 5.0 COc1ccc([C@@H]2c3nc(CC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL102314 4532 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 445 6 1 5 5.0 COc1ccc([C@@H]2c3nc(CC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
9852318 9612 None 8 Rat Binding pIC50 = 9.5 9.5 - 2
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
CHEMBL112624 9612 None 8 Rat Binding pIC50 = 9.5 9.5 - 2
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
CHEMBL1627022 9612 None 8 Rat Binding pIC50 = 9.5 9.5 - 2
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
11102201 203221 None 0 Rat Binding pIC50 = 9.5 9.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 438 9 1 6 5.1 C=CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL64447 203221 None 0 Rat Binding pIC50 = 9.5 9.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 438 9 1 6 5.1 C=CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
44266903 14584 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 536 11 1 9 4.4 COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL10862 14584 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 536 11 1 9 4.4 COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL1204672 14584 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 536 11 1 9 4.4 COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm9606507
9960931 108019 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 635 12 1 12 4.1 CCOC(=O)CNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
CHEMBL319452 108019 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 635 12 1 12 4.1 CCOC(=O)CNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
159594 522 None 45 Rat Binding pIC50 = 9.4 9.4 -1 3
Binding affinity against Endothelin A receptor in MMQ cells in ratBinding affinity against Endothelin A receptor in MMQ cells in rat
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
3487 522 None 45 Rat Binding pIC50 = 9.4 9.4 -1 3
Binding affinity against Endothelin A receptor in MMQ cells in ratBinding affinity against Endothelin A receptor in MMQ cells in rat
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
CHEMBL9194 522 None 45 Rat Binding pIC50 = 9.4 9.4 -1 3
Binding affinity against Endothelin A receptor in MMQ cells in ratBinding affinity against Endothelin A receptor in MMQ cells in rat
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
DB06199 522 None 45 Rat Binding pIC50 = 9.4 9.4 -1 3
Binding affinity against Endothelin A receptor in MMQ cells in ratBinding affinity against Endothelin A receptor in MMQ cells in rat
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
9914310 206641 None 8 Rat Binding pIC50 = 9.4 9.4 - 2
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL8923 206641 None 8 Rat Binding pIC50 = 9.4 9.4 - 2
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
9870830 206712 None 38 Human Binding pIC50 = 9.4 9.4 66 2
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL8981 206712 None 38 Human Binding pIC50 = 9.4 9.4 66 2
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/S0960-894X(97)00002-4
11017436 9948 None 0 Pig Binding pIC50 = 9.4 9.4 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 597 12 1 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCOc1ncc(SC)cn1 10.1021/jm0102304
CHEMBL114660 9948 None 0 Pig Binding pIC50 = 9.4 9.4 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 597 12 1 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCOc1ncc(SC)cn1 10.1021/jm0102304
44333913 5099 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 431 6 1 5 4.8 CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL105591 5099 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 431 6 1 5 4.8 CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
9870959 8915 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 509 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 10.1021/jm980217s
CHEMBL109778 8915 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 509 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 10.1021/jm980217s
9809526 14857 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 614 12 2 11 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCS(=O)(=O)O)c2)cc1 10.1021/jm980504w
CHEMBL1207463 14857 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 614 12 2 11 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCS(=O)(=O)O)c2)cc1 10.1021/jm980504w
CHEMBL408055 14857 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 614 12 2 11 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCS(=O)(=O)O)c2)cc1 10.1021/jm980504w
44284481 213723 None 0 Human Binding pIC50 = 9.4 9.4 -4 5
Inhibition of human ETA receptorInhibition of human ETA receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm701575k
CHEMBL437472 213723 None 0 Human Binding pIC50 = 9.4 9.4 -4 5
Inhibition of human ETA receptorInhibition of human ETA receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm701575k
10208674 101851 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 529 7 2 7 5.6 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)c2ccccc2)c1 10.1021/jm030528p
CHEMBL300547 101851 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 529 7 2 7 5.6 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)c2ccccc2)c1 10.1021/jm030528p
10603409 110602 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
CHEMBL325581 110602 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
9852318 9612 None 8 Human Binding pIC50 = 9.4 9.4 2691 2
Antagonist activity at ET-A receptor (unknown origin)Antagonist activity at ET-A receptor (unknown origin)
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/acs.jmedchem.5b01781
CHEMBL112624 9612 None 8 Human Binding pIC50 = 9.4 9.4 2691 2
Antagonist activity at ET-A receptor (unknown origin)Antagonist activity at ET-A receptor (unknown origin)
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/acs.jmedchem.5b01781
CHEMBL1627022 9612 None 8 Human Binding pIC50 = 9.4 9.4 2691 2
Antagonist activity at ET-A receptor (unknown origin)Antagonist activity at ET-A receptor (unknown origin)
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/acs.jmedchem.5b01781
44332735 172700 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 649 13 1 12 4.5 CCOC(=O)CCNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
CHEMBL450337 172700 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 649 13 1 12 4.5 CCOC(=O)CCNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
159594 522 None 45 Rat Binding pIC50 = 9.4 9.4 -1 3
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm960077r
3487 522 None 45 Rat Binding pIC50 = 9.4 9.4 -1 3
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm960077r
CHEMBL9194 522 None 45 Rat Binding pIC50 = 9.4 9.4 -1 3
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm960077r
DB06199 522 None 45 Rat Binding pIC50 = 9.4 9.4 -1 3
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm960077r
9852318 9612 None 8 Human Binding pIC50 = 9.4 9.4 2691 2
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
CHEMBL112624 9612 None 8 Human Binding pIC50 = 9.4 9.4 2691 2
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
CHEMBL1627022 9612 None 8 Human Binding pIC50 = 9.4 9.4 2691 2
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
71462245 81664 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 588 13 2 10 3.6 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cc(OC)ccc1Cl 10.1021/jm3009103
CHEMBL2163692 81664 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 588 13 2 10 3.6 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cc(OC)ccc1Cl 10.1021/jm3009103
44386169 131387 None 0 Human Binding pIC50 = 9.4 9.4 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 690 12 2 14 3.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL368996 131387 None 0 Human Binding pIC50 = 9.4 9.4 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 690 12 2 14 3.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
11122784 162920 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 8 1 6 4.9 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL417413 162920 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 8 1 6 4.9 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
44339655 9104 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 530 14 1 6 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL109926 9104 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 530 14 1 6 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
44284196 100521 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 504 9 2 7 5.4 CCCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
CHEMBL291247 100521 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 504 9 2 7 5.4 CCCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
10364227 202797 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm031041j
CHEMBL62264 202797 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm031041j
10364227 202797 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL62264 202797 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
9806559 9148 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 515 13 1 6 3.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O 10.1021/jm980217s
CHEMBL110053 9148 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 515 13 1 6 3.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O 10.1021/jm980217s
11827880 10224 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 565 10 1 9 5.5 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 10.1021/jm0102304
CHEMBL116046 10224 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 565 10 1 9 5.5 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 10.1021/jm0102304
CHEMBL177979 10224 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 565 10 1 9 5.5 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 10.1021/jm0102304
CHEMBL1790962 208908 None 0 Pig Binding pIC50 = 9.4 9.4 - 1
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
10303555 163379 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 574 15 1 7 4.9 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
CHEMBL419383 163379 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 574 15 1 7 4.9 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
10578320 97308 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 538 12 1 6 5.2 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CCC(C)C)CCC(C)C)cc1 10.1021/jm9505369
CHEMBL269141 97308 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 538 12 1 6 5.2 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CCC(C)C)CCC(C)C)cc1 10.1021/jm9505369
10182624 99551 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 453 6 2 6 4.9 CCc1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm000349x
CHEMBL283582 99551 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 453 6 2 6 4.9 CCc1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm000349x
9870830 206712 None 38 Rat Binding pIC50 = 9.4 9.4 - 2
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/s0960-894x(97)10151-2
CHEMBL8981 206712 None 38 Rat Binding pIC50 = 9.4 9.4 - 2
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/s0960-894x(97)10151-2
9825494 202608 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity at human Endothelin A receptorBinding affinity at human Endothelin A receptor
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL61211 202608 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity at human Endothelin A receptorBinding affinity at human Endothelin A receptor
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
44380648 120511 None 0 Pig Binding pIC50 = 9.4 9.4 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 727 12 1 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCN(C)CC2)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
CHEMBL354528 120511 None 0 Pig Binding pIC50 = 9.4 9.4 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 727 12 1 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCN(C)CC2)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
10210629 8762 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL109644 8762 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
10167052 109637 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 578 13 1 7 4.5 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCC(C)C 10.1021/jm970101g
CHEMBL322297 109637 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 578 13 1 7 4.5 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCC(C)C 10.1021/jm970101g
44265870 207569 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 524 12 1 6 5.1 CCCCN(CCCC)C(=O)C(C)N1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9488 207569 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 524 12 1 6 5.1 CCCCN(CCCC)C(=O)C(C)N1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
10391487 9659 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
CHEMBL112832 9659 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
10983045 202904 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 440 9 1 6 5.3 CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL62762 202904 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 440 9 1 6 5.3 CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
11050177 10257 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 585 10 1 9 6.1 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccco3)cn2)cc1 10.1021/jm0102304
CHEMBL116108 10257 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 585 10 1 9 6.1 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccco3)cn2)cc1 10.1021/jm0102304
CHEMBL175501 10257 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 585 10 1 9 6.1 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccco3)cn2)cc1 10.1021/jm0102304
9915028 9409 None 18 Human Binding pIC50 = 9.3 9.3 28183 2
Inhibitory activity against human endothelin A receptorInhibitory activity against human endothelin A receptor
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm010237l
CHEMBL111612 9409 None 18 Human Binding pIC50 = 9.3 9.3 28183 2
Inhibitory activity against human endothelin A receptorInhibitory activity against human endothelin A receptor
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm010237l
CHEMBL4761843 9409 None 18 Human Binding pIC50 = 9.3 9.3 28183 2
Inhibitory activity against human endothelin A receptorInhibitory activity against human endothelin A receptor
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm010237l
10391487 9659 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm031041j
CHEMBL112832 9659 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm031041j
10840068 60355 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 536 11 1 9 4.4 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL174573 60355 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 536 11 1 9 4.4 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm031041j
44387124 130889 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 524 13 1 6 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](CC(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm031041j
CHEMBL368558 130889 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 524 13 1 6 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](CC(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm031041j
10530409 5704 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 536 9 1 10 3.9 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
CHEMBL10781 5704 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 536 9 1 10 3.9 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
10815823 9795 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 520 8 1 9 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C 10.1021/jm9606507
CHEMBL11369 9795 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 520 8 1 9 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C 10.1021/jm9606507
15411009 107188 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 691 14 1 12 5.6 CCOC(=O)C(CC(C)C)NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
CHEMBL316523 107188 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 691 14 1 12 5.6 CCOC(=O)C(CC(C)C)NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
10391487 9659 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL112832 9659 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
16004692 2452 None 91 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
4809 2452 None 91 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
7352 2452 None 91 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
CHEMBL2103873 2452 None 91 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
DB08932 2452 None 91 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
157574 78388 None 11 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 517 4 1 5 5.0 CCc1cc(C2=C(C(=O)O)N(c3ccccc3C(F)(F)F)S(=O)(=O)c3ccccc32)cc2c1OCO2 10.1016/j.bmcl.2016.06.014
CHEMBL2110610 78388 None 11 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 517 4 1 5 5.0 CCc1cc(C2=C(C(=O)O)N(c3ccccc3C(F)(F)F)S(=O)(=O)c3ccccc32)cc2c1OCO2 10.1016/j.bmcl.2016.06.014
21041283 173145 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 552 13 2 9 3.2 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4521348 173145 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 552 13 2 9 3.2 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
155544917 173412 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 540 13 2 10 3.4 CCCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 10.1016/j.bmcl.2016.06.014
CHEMBL4528516 173412 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 540 13 2 10 3.4 CCCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 10.1016/j.bmcl.2016.06.014
16004692 2452 None 91 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1021/jm3009103
4809 2452 None 91 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1021/jm3009103
7352 2452 None 91 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1021/jm3009103
CHEMBL2103873 2452 None 91 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1021/jm3009103
DB08932 2452 None 91 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1021/jm3009103
44279554 99324 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 512 11 2 7 3.8 COCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(C)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL282187 99324 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 512 11 2 7 3.8 COCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(C)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
11754394 108626 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 468 8 2 6 3.8 CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(C)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL32066 108626 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 468 8 2 6 3.8 CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(C)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
9933950 202824 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL62395 202824 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
10553384 109666 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 498 13 1 7 3.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 10.1021/jm980217s
CHEMBL322537 109666 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 498 13 1 7 3.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 10.1021/jm980217s
44333721 167791 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 447 7 1 6 4.3 CCOCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL430506 167791 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 447 7 1 6 4.3 CCOCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
9916235 9351 None 1 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL111277 9351 None 1 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
10994374 203414 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 7 1 6 5.4 COc1ccc(CC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL65619 203414 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 7 1 6 5.4 COc1ccc(CC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
10651146 108862 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 596 12 1 8 4.4 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(OC)cc1 10.1021/jm970101g
CHEMBL321035 108862 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 596 12 1 8 4.4 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(OC)cc1 10.1021/jm970101g
10982740 203381 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 422 5 1 5 5.4 CC(C)Oc1ccc2c(c1)C(C1CCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL65353 203381 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 422 5 1 5 5.4 CC(C)Oc1ccc2c(c1)C(C1CCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10187997 109970 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL323464 109970 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
10651488 163377 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
CHEMBL419367 163377 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
9915510 85153 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 549 8 2 8 3.4 CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
CHEMBL22513 85153 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 549 8 2 8 3.4 CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
9915510 85153 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 549 8 2 8 3.4 CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1007/s00044-004-0021-y
CHEMBL22513 85153 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 549 8 2 8 3.4 CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1007/s00044-004-0021-y
44334097 110067 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 447 7 2 6 3.7 COc1ccc([C@@H]2c3nc(CCCO)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL323561 110067 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 447 7 2 6 3.7 COc1ccc([C@@H]2c3nc(CCCO)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
10719598 206988 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 482 10 1 6 3.9 CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9139 206988 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 482 10 1 6 3.9 CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
9915028 9409 None 18 Rat Binding pIC50 = 9.3 9.3 - 2
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
CHEMBL111612 9409 None 18 Rat Binding pIC50 = 9.3 9.3 - 2
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
CHEMBL4761843 9409 None 18 Rat Binding pIC50 = 9.3 9.3 - 2
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
10886132 9807 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 549 10 1 9 4.8 COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 10.1021/jm0102304
CHEMBL113757 9807 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 549 10 1 9 4.8 COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 10.1021/jm0102304
CHEMBL368796 9807 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 549 10 1 9 4.8 COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 10.1021/jm0102304
10744973 207274 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 538 14 1 6 5.5 CCCCCN(CCCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9313 207274 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 538 14 1 6 5.5 CCCCCN(CCCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10209779 163429 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 560 14 1 7 4.5 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
CHEMBL419749 163429 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 560 14 1 7 4.5 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
11015826 203529 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 450 6 1 5 6.1 CC(C)Oc1ccc2c(c1)C(CC1CCCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL66426 203529 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 450 6 1 5 6.1 CC(C)Oc1ccc2c(c1)C(CC1CCCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
9915028 9409 None 18 Human Binding pIC50 = 9.2 9.2 28183 2
Affinity On-target Cellular interaction (Endothelin-1-evoked phosphatidylinositol hydrolysis in MMQ cells) EUB0000348aPTSA EDNRAAffinity On-target Cellular interaction (Endothelin-1-evoked phosphatidylinositol hydrolysis in MMQ cells) EUB0000348aPTSA EDNRA
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL5210121
CHEMBL111612 9409 None 18 Human Binding pIC50 = 9.2 9.2 28183 2
Affinity On-target Cellular interaction (Endothelin-1-evoked phosphatidylinositol hydrolysis in MMQ cells) EUB0000348aPTSA EDNRAAffinity On-target Cellular interaction (Endothelin-1-evoked phosphatidylinositol hydrolysis in MMQ cells) EUB0000348aPTSA EDNRA
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL5210121
CHEMBL4761843 9409 None 18 Human Binding pIC50 = 9.2 9.2 28183 2
Affinity On-target Cellular interaction (Endothelin-1-evoked phosphatidylinositol hydrolysis in MMQ cells) EUB0000348aPTSA EDNRAAffinity On-target Cellular interaction (Endothelin-1-evoked phosphatidylinositol hydrolysis in MMQ cells) EUB0000348aPTSA EDNRA
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL5210121
10346184 9194 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
CHEMBL110366 9194 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
15411005 4758 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 677 13 1 12 5.2 CCOC(=O)C(NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1)C(C)C 10.1016/S0960-894X(97)00002-4
CHEMBL103846 4758 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 677 13 1 12 5.2 CCOC(=O)C(NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1)C(C)C 10.1016/S0960-894X(97)00002-4
10346184 9194 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL110366 9194 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL2373291 210372 None 0 Pig Binding pIC50 = 9.2 9.2 - 1
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
10579303 9429 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 590 16 1 8 4.5 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCOC)cc1 10.1021/jm970101g
CHEMBL111712 9429 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 590 16 1 8 4.5 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCOC)cc1 10.1021/jm970101g
11015645 203185 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 438 9 1 5 6.1 CCCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL64282 203185 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 438 9 1 5 6.1 CCCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10938122 163004 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 396 5 1 5 4.8 CC(C)Oc1ccc2c(c1)C(C(C)C)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL417555 163004 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 396 5 1 5 4.8 CC(C)Oc1ccc2c(c1)C(C(C)C)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10503921 101474 None 0 Human Binding pIC50 = 9.2 9.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 8 4.0 Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1noc(C)c1Cl)OCO2 10.1021/jm9700068
CHEMBL297783 101474 None 0 Human Binding pIC50 = 9.2 9.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 8 4.0 Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1noc(C)c1Cl)OCO2 10.1021/jm9700068
44279141 107021 None 0 Human Binding pIC50 = 9.2 9.2 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 498 10 3 7 3.2 COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(=O)NCCO)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL31544 107021 None 0 Human Binding pIC50 = 9.2 9.2 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 498 10 3 7 3.2 COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(=O)NCCO)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
10552883 110002 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 484 13 1 5 4.8 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C1CC1 10.1021/jm980217s
CHEMBL323485 110002 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 484 13 1 5 4.8 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C1CC1 10.1021/jm980217s
10974047 9515 None 0 Pig Binding pIC50 = 9.2 9.2 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 11 1 10 4.3 COc1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(C)cc2)cc1OC 10.1021/jm0102304
CHEMBL112162 9515 None 0 Pig Binding pIC50 = 9.2 9.2 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 11 1 10 4.3 COc1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(C)cc2)cc1OC 10.1021/jm0102304
10745942 9309 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 588 13 1 8 4.3 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc2c(c1)OCCO2 10.1021/jm970101g
CHEMBL111010 9309 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 588 13 1 8 4.3 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc2c(c1)OCCO2 10.1021/jm970101g
11080933 203410 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 454 10 1 6 5.7 CCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL65599 203410 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 454 10 1 6 5.7 CCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10166223 202709 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 552 7 2 7 5.5 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)N(C)CC(C)(C)C)c1 10.1021/jm030528p
CHEMBL61711 202709 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 552 7 2 7 5.5 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)N(C)CC(C)(C)C)c1 10.1021/jm030528p
10076527 14613 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 485 7 2 6 4.3 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3ccccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1204990 14613 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 485 7 2 6 4.3 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3ccccc31)OCO2 10.1016/j.bmcl.2010.08.074
10720982 127815 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 530 9 2 6 4.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 10.1021/jm031041j
CHEMBL121647 127815 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 530 9 2 6 4.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 10.1021/jm031041j
CHEMBL366441 127815 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 530 9 2 6 4.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 10.1021/jm031041j
71462320 82002 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 570 11 2 8 3.9 Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL2165332 82002 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 570 11 2 8 3.9 Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1016/j.bmcl.2016.06.014
10720982 127815 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 530 9 2 6 4.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 10.1021/jm990171i
CHEMBL121647 127815 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 530 9 2 6 4.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 10.1021/jm990171i
CHEMBL366441 127815 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 530 9 2 6 4.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 10.1021/jm990171i
10649266 9630 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3ccoc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL112685 9630 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3ccoc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
11505449 171482 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 616 12 3 9 2.6 O=C(O)CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4463633 171482 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 616 12 3 9 2.6 O=C(O)CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
58688005 174958 None 1 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 540 11 2 9 3.1 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4565926 174958 None 1 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 540 11 2 9 3.1 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
71462320 82002 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 570 11 2 8 3.9 Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
CHEMBL2165332 82002 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 570 11 2 8 3.9 Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
10746431 102304 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 619 12 1 11 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN3CCOCC3)c2)cc1 10.1021/jm980504w
CHEMBL303484 102304 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 619 12 1 11 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN3CCOCC3)c2)cc1 10.1021/jm980504w
9809919 204407 None 0 Human Binding pIC50 = 9.2 9.2 - 2
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL 665 13 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL72037 204407 None 0 Human Binding pIC50 = 9.2 9.2 - 2
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL 665 13 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL2373292 210373 None 0 Pig Binding pIC50 = 9.2 9.2 - 1
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
9870959 8915 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 509 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 10.1021/jm980217s
CHEMBL109778 8915 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 509 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 10.1021/jm980217s
10916597 203313 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL64832 203313 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
44284184 139998 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 490 8 2 7 5.0 CCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
CHEMBL38000 139998 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 490 8 2 7 5.0 CCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
CHEMBL427748 213370 None 0 Pig Binding pIC50 = 9.1 9.1 - 0
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
11827489 116984 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 524 12 1 4 5.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 10.1021/jm010237l
CHEMBL338754 116984 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 524 12 1 4 5.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 10.1021/jm010237l
10984671 9471 None 0 Pig Binding pIC50 = 9.1 9.1 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 571 10 1 9 4.3 COc1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(C)cc2)cc1 10.1021/jm0102304
CHEMBL111934 9471 None 0 Pig Binding pIC50 = 9.1 9.1 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 571 10 1 9 4.3 COc1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(C)cc2)cc1 10.1021/jm0102304
10648006 161664 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 468 6 1 6 4.7 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1021/jm9700068
CHEMBL413093 161664 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 468 6 1 6 4.7 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1021/jm9700068
10648135 9340 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 472 13 1 5 4.7 C/C=C/CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm031041j
CHEMBL111218 9340 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 472 13 1 5 4.7 C/C=C/CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm031041j
10209320 9283 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 12 1 7 4.0 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC(C)C 10.1021/jm970101g
CHEMBL110899 9283 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 12 1 7 4.0 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC(C)C 10.1021/jm970101g
11038320 18871 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 492 11 1 4 5.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 10.1021/jm010237l
CHEMBL128240 18871 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 492 11 1 4 5.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 10.1021/jm010237l
44340049 110329 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 500 13 1 5 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL323951 110329 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 500 13 1 5 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
10552413 110666 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 472 13 1 5 4.7 C/C=C\CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL325935 110666 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 472 13 1 5 4.7 C/C=C\CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
44266851 14583 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 550 11 1 9 4.7 COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1C 10.1021/jm9606507
CHEMBL10847 14583 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 550 11 1 9 4.7 COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1C 10.1021/jm9606507
CHEMBL1204671 14583 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 550 11 1 9 4.7 COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1C 10.1021/jm9606507
44279316 107344 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 518 8 2 6 4.0 COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL31763 107344 None 0 Human Binding pIC50 = 9.1 9.1 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 518 8 2 6 4.0 COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
137649592 157408 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 567 10 2 9 4.6 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4078537 157408 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 567 10 2 9 4.6 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
15411003 108718 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 589 11 1 10 4.8 C=CCNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
CHEMBL320839 108718 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 589 11 1 10 4.8 C=CCNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
10673644 9780 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 524 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL113611 9780 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 524 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
177236 1324 None 45 Human Binding pIC50 = 9.1 9.1 2 3
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00660-6
3508 1324 None 45 Human Binding pIC50 = 9.1 9.1 2 3
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00660-6
CHEMBL23261 1324 None 45 Human Binding pIC50 = 9.1 9.1 2 3
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00660-6
DB04883 1324 None 45 Human Binding pIC50 = 9.1 9.1 2 3
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00660-6
71462322 82008 None 11 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 572 10 2 8 3.2 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
CHEMBL2165338 82008 None 11 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 572 10 2 8 3.2 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
44284199 100108 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 552 9 2 7 6.2 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCc2ccccc2)c1 10.1016/j.bmcl.2004.01.008
CHEMBL287517 100108 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 552 9 2 7 6.2 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCc2ccccc2)c1 10.1016/j.bmcl.2004.01.008
10993320 202978 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 6 1 6 4.6 CC(C)OC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL63067 202978 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 6 1 6 4.6 CC(C)OC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10097589 206279 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 502 7 2 7 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCC(C(=O)O)CC1 10.1016/s0960-894x(00)00513-8
CHEMBL86965 206279 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 502 7 2 7 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCC(C(=O)O)CC1 10.1016/s0960-894x(00)00513-8
10792319 207232 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 530 10 1 6 5.1 CCCCN(C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm9505369
CHEMBL9283 207232 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 530 10 1 6 5.1 CCCCN(C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm9505369
10648937 207304 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 496 11 1 6 4.3 CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9334 207304 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 496 11 1 6 4.3 CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10673644 9780 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 524 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
CHEMBL113611 9780 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 524 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
10814655 207598 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 10 1 6 3.9 CCCCN(CC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9502 207598 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 10 1 6 3.9 CCCCN(CC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
44339714 111306 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 500 14 1 5 5.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC/C=C(/C)CC 10.1021/jm980217s
CHEMBL326685 111306 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 500 14 1 5 5.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC/C=C(/C)CC 10.1021/jm980217s
10984617 10006 None 0 Pig Binding pIC50 = 9.1 9.1 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 565 11 1 10 4.9 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(C)cn2)c1 10.1021/jm0102304
CHEMBL114933 10006 None 0 Pig Binding pIC50 = 9.1 9.1 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 565 11 1 10 4.9 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(C)cn2)c1 10.1021/jm0102304
44284183 139573 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 9 2 7 5.7 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCC(C)C)c1 10.1016/j.bmcl.2004.01.008
CHEMBL37973 139573 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 9 2 7 5.7 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCC(C)C)c1 10.1016/j.bmcl.2004.01.008
11027946 18911 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 540 12 1 5 5.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 10.1021/jm010237l
CHEMBL128479 18911 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 540 12 1 5 5.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 10.1021/jm010237l
11006213 169267 None 0 Pig Binding pIC50 = 9.1 9.1 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 557 10 1 10 5.3 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2cccs2)nc1 10.1021/jm0102304
CHEMBL441277 169267 None 0 Pig Binding pIC50 = 9.1 9.1 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 557 10 1 10 5.3 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2cccs2)nc1 10.1021/jm0102304
10602743 7155 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 550 9 1 10 4.2 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C 10.1021/jm9606507
CHEMBL10854 7155 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 550 9 1 10 4.2 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C 10.1021/jm9606507
10983992 19459 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 506 12 1 4 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 10.1021/jm010237l
CHEMBL129740 19459 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 506 12 1 4 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 10.1021/jm010237l
44333598 109188 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 447 7 1 6 4.6 CCCOc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL321520 109188 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 447 7 1 6 4.6 CCCOc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
11037806 202822 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 456 10 2 7 4.3 CC(C)Oc1ccc2c(c1)C(OCCCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL62376 202822 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 456 10 2 7 4.3 CC(C)Oc1ccc2c(c1)C(OCCCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10788494 170621 None 0 Human Binding pIC50 = 9.0 9.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 424 6 1 6 4.5 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm9700068
CHEMBL445101 170621 None 0 Human Binding pIC50 = 9.0 9.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 424 6 1 6 4.5 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm9700068
10768294 14586 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 520 10 1 8 4.7 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1C 10.1021/jm9606507
CHEMBL10922 14586 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 520 10 1 8 4.7 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1C 10.1021/jm9606507
CHEMBL1204674 14586 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 520 10 1 8 4.7 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1C 10.1021/jm9606507
10625694 11444 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 516 9 2 6 4.5 CCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
CHEMBL1180344 11444 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 516 9 2 6 4.5 CCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
CHEMBL123107 11444 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 516 9 2 6 4.5 CCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
9868379 100781 None 0 Rat Binding pIC50 = 9 9.0 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 450 5 1 6 5.6 Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 10.1021/jm010382z
CHEMBL293012 100781 None 0 Rat Binding pIC50 = 9 9.0 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 450 5 1 6 5.6 Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 10.1021/jm010382z
44332842 109719 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 703 11 1 10 7.5 COc1ccc(C2(OC(=O)N[C@@H](C)c3cccc4ccccc34)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL322920 109719 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 703 11 1 10 7.5 COc1ccc(C2(OC(=O)N[C@@H](C)c3cccc4ccccc34)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/S0960-894X(97)00002-4
44314904 103145 None 0 Pig Binding pIC50 = 9 9.0 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 585 12 5 5 3.6 CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
CHEMBL307936 103145 None 0 Pig Binding pIC50 = 9 9.0 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 585 12 5 5 3.6 CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
10649321 110944 None 0 Rat Binding pIC50 = 9 9.0 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL326191 110944 None 0 Rat Binding pIC50 = 9 9.0 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
3951 391 None 86 Human Binding pIC50 = 9 9.0 -1 2
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
4337 391 None 86 Human Binding pIC50 = 9 9.0 -1 2
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
6918493 391 None 86 Human Binding pIC50 = 9 9.0 -1 2
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
CHEMBL1111 391 None 86 Human Binding pIC50 = 9 9.0 -1 2
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
DB06403 391 None 86 Human Binding pIC50 = 9 9.0 -1 2
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
9868379 100781 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 450 5 1 6 5.6 Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 10.1016/j.bmcl.2016.06.014
CHEMBL293012 100781 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 450 5 1 6 5.6 Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 10.1016/j.bmcl.2016.06.014
155519384 170416 None 0 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 674 12 1 13 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)c1ccccn1 10.1016/j.bmcl.2016.06.014
CHEMBL4448273 170416 None 0 Human Binding pIC50 = 9 9.0 - 1
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 674 12 1 13 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)c1ccccn1 10.1016/j.bmcl.2016.06.014
155551580 173991 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 526 12 2 10 3.0 CCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 10.1016/j.bmcl.2016.06.014
CHEMBL4542394 173991 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 526 12 2 10 3.0 CCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 10.1016/j.bmcl.2016.06.014
10146305 174269 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 656 14 2 13 4.2 COc1ccccc1Oc1c(NS(=O)(=O)CCc2cccs2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
CHEMBL4549357 174269 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 656 14 2 13 4.2 COc1ccccc1Oc1c(NS(=O)(=O)CCc2cccs2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
44439102 90297 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 508 8 1 7 5.2 CN(Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1ccno1)C(=O)CC(C)(C)C 10.1016/j.bmcl.2006.10.009
CHEMBL238539 90297 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 508 8 1 7 5.2 CN(Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1ccno1)C(=O)CC(C)(C)C 10.1016/j.bmcl.2006.10.009
71460621 81999 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 602 13 2 10 3.7 COc1cccc(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1021/jm3009103
CHEMBL2165329 81999 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 602 13 2 10 3.7 COc1cccc(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1021/jm3009103
44295173 14631 None 0 Rat Binding pIC50 = 9 9.0 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 554 10 1 9 5.3 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1Cl 10.1016/s0960-894x(98)00301-1
CHEMBL1205090 14631 None 0 Rat Binding pIC50 = 9 9.0 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 554 10 1 9 5.3 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1Cl 10.1016/s0960-894x(98)00301-1
CHEMBL51234 14631 None 0 Rat Binding pIC50 = 9 9.0 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 554 10 1 9 5.3 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1Cl 10.1016/s0960-894x(98)00301-1
44279398 99887 None 0 Human Binding pIC50 = 9 9.0 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 454 8 2 6 3.6 COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL285976 99887 None 0 Human Binding pIC50 = 9 9.0 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 454 8 2 6 3.6 COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
44279294 99894 None 0 Human Binding pIC50 = 9 9.0 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 546 8 1 6 4.6 COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(=O)N(C)C)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL286014 99894 None 0 Human Binding pIC50 = 9 9.0 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 546 8 1 6 4.6 COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(=O)N(C)C)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
10897248 9507 None 0 Pig Binding pIC50 = 9 9.0 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 591 9 1 8 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3ccc4ccccc4c3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL112134 9507 None 0 Pig Binding pIC50 = 9 9.0 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 591 9 1 8 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3ccc4ccccc4c3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
11136124 10368 None 0 Pig Binding pIC50 = 9 9.0 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 667 9 1 8 4.9 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(I)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL116220 10368 None 0 Pig Binding pIC50 = 9 9.0 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 667 9 1 8 4.9 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(I)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
10211781 129739 None 0 Human Binding pIC50 = 9 9.0 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL367453 129739 None 0 Human Binding pIC50 = 9 9.0 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
10146640 207552 None 0 Human Binding pIC50 = 9 9.0 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 689 12 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL94786 207552 None 0 Human Binding pIC50 = 9 9.0 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 689 12 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
10555191 203790 None 0 Human Binding pIC50 = 9 9.0 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 577 12 1 10 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN(C)C)c2)cc1 10.1021/jm980504w
CHEMBL68269 203790 None 0 Human Binding pIC50 = 9 9.0 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 577 12 1 10 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN(C)C)c2)cc1 10.1021/jm980504w
CHEMBL1790519 208891 None 0 Human Binding pIC50 = 9 9.0 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N(C)[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1021/jm970161m
44311346 103161 None 0 Human Binding pIC50 = 9 9.0 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 681 13 2 13 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCSCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL308088 103161 None 0 Human Binding pIC50 = 9 9.0 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 681 13 2 13 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCSCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44340049 110329 None 0 Human Binding pIC50 = 9 9.0 - 0
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 500 13 1 5 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL323951 110329 None 0 Human Binding pIC50 = 9 9.0 - 0
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 500 13 1 5 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
44339662 9850 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 527 13 1 7 4.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1nc(C)c(C)o1 10.1021/jm980217s
CHEMBL114074 9850 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 527 13 1 7 4.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1nc(C)c(C)o1 10.1021/jm980217s
44351961 18834 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 522 13 1 5 5.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCC)cc1 10.1021/jm010237l
CHEMBL128061 18834 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 522 13 1 5 5.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCC)cc1 10.1021/jm010237l
10553384 109666 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 498 13 1 7 3.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 10.1021/jm980217s
CHEMBL322537 109666 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 498 13 1 7 3.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 10.1021/jm980217s
9909467 205509 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 409 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80782 205509 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 409 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1Br 10.1016/0960-894X(96)00441-6
9827093 173422 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 494 9 2 7 5.1 CCCc1nc(SC2CCC(CC(=O)O)CC2)c(C(=O)O)n1Cc1cc2c(cc1Cl)OCO2 10.1016/j.bmcl.2016.06.014
CHEMBL4528664 173422 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 494 9 2 7 5.1 CCCc1nc(SC2CCC(CC(=O)O)CC2)c(C(=O)O)n1Cc1cc2c(cc1Cl)OCO2 10.1016/j.bmcl.2016.06.014
10347080 85225 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 535 7 2 8 3.0 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
CHEMBL22562 85225 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 535 7 2 8 3.0 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
10347080 85225 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 535 7 2 8 3.0 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1007/s00044-004-0021-y
CHEMBL22562 85225 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 535 7 2 8 3.0 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1007/s00044-004-0021-y
71449713 81666 None 27 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 585 11 1 8 4.5 CCCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
CHEMBL2163694 81666 None 27 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 585 11 1 8 4.5 CCCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
71458719 81676 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 647 15 1 13 4.7 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(SC)cn1 10.1021/jm3009103
CHEMBL2163704 81676 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 647 15 1 13 4.7 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(SC)cn1 10.1021/jm3009103
17885918 105971 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 458 6 1 6 5.9 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccsc2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
CHEMBL313044 105971 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 458 6 1 6 5.9 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccsc2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
9846994 105987 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 458 6 1 6 5.9 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
CHEMBL313153 105987 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 458 6 1 6 5.9 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
44380976 165624 None 0 Pig Binding pIC50 = 9.0 9.0 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 639 10 1 8 6.7 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(C(C)C)nc2OCCOc2ncc(Br)cn2)cc1 10.1016/s0960-894x(01)00682-5
CHEMBL424358 165624 None 0 Pig Binding pIC50 = 9.0 9.0 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 639 10 1 8 6.7 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(C(C)C)nc2OCCOc2ncc(Br)cn2)cc1 10.1016/s0960-894x(01)00682-5
10505755 14582 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 506 10 1 8 4.4 COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL10832 14582 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 506 10 1 8 4.4 COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL1204670 14582 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 506 10 1 8 4.4 COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
9870830 206712 None 38 Human Binding pIC50 = 9.0 9.0 66 2
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
CHEMBL8981 206712 None 38 Human Binding pIC50 = 9.0 9.0 66 2
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
10142669 9442 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 518 11 1 7 3.3 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC 10.1021/jm970101g
CHEMBL111769 9442 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 518 11 1 7 3.3 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC 10.1021/jm970101g
137637038 155939 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 581 11 2 9 5.0 CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4061110 155939 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 581 11 2 9 5.0 CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
10649321 110944 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
CHEMBL326191 110944 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
10576427 5368 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 473 6 2 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(NC(C)=O)cc2)cc1 10.1021/jm9606507
CHEMBL10697 5368 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 473 6 2 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(NC(C)=O)cc2)cc1 10.1021/jm9606507
21041324 81662 None 5 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 542 11 2 8 3.5 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 10.1021/jm3009103
CHEMBL2163690 81662 None 5 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 542 11 2 8 3.5 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 10.1021/jm3009103
11093167 10051 None 0 Pig Binding pIC50 = 8.9 8.9 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 593 11 1 9 6.3 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C(C)C)cc2)nc1 10.1021/jm0102304
CHEMBL115230 10051 None 0 Pig Binding pIC50 = 8.9 8.9 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 593 11 1 9 6.3 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C(C)C)cc2)nc1 10.1021/jm0102304
11813644 110375 None 0 Pig Binding pIC50 = 8.9 8.9 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccncn2)c1 10.1021/jm0102304
CHEMBL324246 110375 None 0 Pig Binding pIC50 = 8.9 8.9 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccncn2)c1 10.1021/jm0102304
CHEMBL414165 213113 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibitory effect against Human ET-A receptorInhibitory effect against Human ET-A receptor
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](c2cccs2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10719598 206988 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 10 1 6 3.9 CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9139 206988 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 10 1 6 3.9 CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
44279296 110628 None 0 Human Binding pIC50 = 8.9 8.9 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 532 8 2 6 4.3 CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL32572 110628 None 0 Human Binding pIC50 = 8.9 8.9 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 532 8 2 6 4.3 CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
10206812 199633 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 492 6 2 8 5.0 Cc1cc(-c2ncco2)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL59288 199633 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 492 6 2 8 5.0 Cc1cc(-c2ncco2)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
11102609 168568 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 462 6 1 6 5.2 COc1ccc([C@@H]2c3cc(OC(C)C)ccc3O[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1021/jm031041j
CHEMBL435773 168568 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 462 6 1 6 5.2 COc1ccc([C@@H]2c3cc(OC(C)C)ccc3O[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1021/jm031041j
10603546 110445 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 592 15 1 7 5.0 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCC)c(F)c1 10.1021/jm970101g
CHEMBL324639 110445 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 592 15 1 7 5.0 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCC)c(F)c1 10.1021/jm970101g
11102609 168568 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 462 6 1 6 5.2 COc1ccc([C@@H]2c3cc(OC(C)C)ccc3O[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1021/jm010382z
CHEMBL435773 168568 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 462 6 1 6 5.2 COc1ccc([C@@H]2c3cc(OC(C)C)ccc3O[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1021/jm010382z
10576910 108537 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 486 13 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C(C)C 10.1021/jm980217s
CHEMBL320124 108537 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 486 13 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C(C)C 10.1021/jm980217s
10278777 168130 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 14 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
CHEMBL432974 168130 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 14 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
10767586 9767 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 496 13 1 5 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL113529 9767 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 496 13 1 5 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
58688008 175300 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 496 11 2 9 3.0 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4573273 175300 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 496 11 2 9 3.0 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
23670447 3027 None 2 Rat Binding pIC50 = 8.9 8.9 - 2
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(98)00301-1
999 3027 None 2 Rat Binding pIC50 = 8.9 8.9 - 2
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(98)00301-1
CHEMBL1204799 3027 None 2 Rat Binding pIC50 = 8.9 8.9 - 2
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(98)00301-1
CHEMBL25438 3027 None 2 Rat Binding pIC50 = 8.9 8.9 - 2
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(98)00301-1
44320480 105956 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 442 6 1 6 5.4 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccco2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
CHEMBL312979 105956 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 442 6 1 6 5.4 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccco2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
17885920 206439 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 502 7 2 7 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCC(C(=O)O)C1 10.1016/s0960-894x(00)00513-8
CHEMBL88011 206439 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 502 7 2 7 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCC(C(=O)O)C1 10.1016/s0960-894x(00)00513-8
44291775 101165 None 0 Human Binding pIC50 = 8.9 8.9 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 506 6 1 10 4.1 CC#N.Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2cc3c(cc2C#N)OCO3)c1Cl 10.1021/jm9700068
CHEMBL295557 101165 None 0 Human Binding pIC50 = 8.9 8.9 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 506 6 1 10 4.1 CC#N.Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2cc3c(cc2C#N)OCO3)c1Cl 10.1021/jm9700068
10280278 100841 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 535 7 2 7 6.1 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C2CCCCC2)c1 10.1021/jm030528p
CHEMBL293421 100841 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 535 7 2 7 6.1 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C2CCCCC2)c1 10.1021/jm030528p
11071347 117804 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 516 11 1 5 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 10.1021/jm010237l
CHEMBL340190 117804 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 516 11 1 5 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 10.1021/jm010237l
10745564 6223 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 566 11 1 7 4.4 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccccc1 10.1021/jm970101g
CHEMBL108142 6223 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 566 11 1 7 4.4 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccccc1 10.1021/jm970101g
11125029 10037 None 0 Pig Binding pIC50 = 8.9 8.9 - 0
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 627 11 2 9 4.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C(=O)O)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
CHEMBL115147 10037 None 0 Pig Binding pIC50 = 8.9 8.9 - 0
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 627 11 2 9 4.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C(=O)O)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
15453177 205519 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80857 205519 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Br 10.1016/0960-894X(96)00441-6
10790757 97211 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2)cc1 10.1021/jm9606507
CHEMBL268480 97211 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2)cc1 10.1021/jm9606507
10554273 9408 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 532 13 1 7 4.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)C1OCCO1 10.1021/jm980217s
CHEMBL111611 9408 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 532 13 1 7 4.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)C1OCCO1 10.1021/jm980217s
8260 531 None 54 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 10.1016/j.bmcl.2016.06.014
9912992 531 None 54 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 10.1016/j.bmcl.2016.06.014
CHEMBL3989834 531 None 54 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 10.1016/j.bmcl.2016.06.014
18630945 170990 None 1 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 507 9 1 9 4.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OC 10.1016/j.bmcl.2016.06.014
CHEMBL4456288 170990 None 1 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 507 9 1 9 4.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OC 10.1016/j.bmcl.2016.06.014
155542285 173075 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 522 14 2 11 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1Oc1cccc(OC)c1 10.1016/j.bmcl.2016.06.014
CHEMBL4519822 173075 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 522 14 2 11 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1Oc1cccc(OC)c1 10.1016/j.bmcl.2016.06.014
11477084 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
216235 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
3548 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
3950 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
CHEMBL282724 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
DB06268 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
22467234 85351 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 534 7 1 8 4.1 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(C)=O)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261599 85351 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 534 7 1 8 4.1 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(C)=O)ccc12 10.1007/s00044-004-0021-y
21041372 81698 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 687 14 2 12 3.6 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(N2CCOCC2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163725 81698 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 687 14 2 12 3.6 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(N2CCOCC2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
21041370 82000 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 636 13 2 10 4.4 COc1ccc(Cl)c(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1021/jm3009103
CHEMBL2165330 82000 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 636 13 2 10 4.4 COc1ccc(Cl)c(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1021/jm3009103
21979593 82003 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 590 11 2 8 4.3 O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 10.1021/jm3009103
CHEMBL2165333 82003 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 590 11 2 8 4.3 O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 10.1021/jm3009103
44295177 14779 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 534 10 1 9 5.0 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1C 10.1016/s0960-894x(98)00301-1
CHEMBL1206680 14779 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 534 10 1 9 5.0 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1C 10.1016/s0960-894x(98)00301-1
CHEMBL295483 14779 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 534 10 1 9 5.0 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1C 10.1016/s0960-894x(98)00301-1
104865 705 None 99 Rat Binding pIC50 = 8.9 8.9 -1 4
In vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptorIn vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
3494 705 None 99 Rat Binding pIC50 = 8.9 8.9 -1 4
In vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptorIn vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
392 705 None 99 Rat Binding pIC50 = 8.9 8.9 -1 4
In vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptorIn vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
CHEMBL957 705 None 99 Rat Binding pIC50 = 8.9 8.9 -1 4
In vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptorIn vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
DB00559 705 None 99 Rat Binding pIC50 = 8.9 8.9 -1 4
In vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptorIn vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
10952199 10021 None 0 Pig Binding pIC50 = 8.9 8.9 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 609 9 1 8 5.3 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(F)(F)F)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL115017 10021 None 0 Pig Binding pIC50 = 8.9 8.9 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 609 9 1 8 5.3 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(F)(F)F)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
11477084 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
216235 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
3548 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
3950 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
CHEMBL282724 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
DB06268 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
11477084 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Inhibitory concentration towards Endothelin A receptor in humanInhibitory concentration towards Endothelin A receptor in human
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
216235 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Inhibitory concentration towards Endothelin A receptor in humanInhibitory concentration towards Endothelin A receptor in human
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
3548 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Inhibitory concentration towards Endothelin A receptor in humanInhibitory concentration towards Endothelin A receptor in human
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
3950 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Inhibitory concentration towards Endothelin A receptor in humanInhibitory concentration towards Endothelin A receptor in human
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
CHEMBL282724 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Inhibitory concentration towards Endothelin A receptor in humanInhibitory concentration towards Endothelin A receptor in human
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
DB06268 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Inhibitory concentration towards Endothelin A receptor in humanInhibitory concentration towards Endothelin A receptor in human
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
11477084 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm000349x
216235 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm000349x
3548 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm000349x
3950 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm000349x
CHEMBL282724 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm000349x
DB06268 3608 None 53 Human Binding pIC50 = 8.9 8.9 1 2
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm000349x
42630655 18405 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 557 11 2 7 5.5 CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271586 18405 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 557 11 2 7 5.5 CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
11409462 198686 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 501 6 2 6 6.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(-c2ccccc2)c1 10.1021/jm030528p
CHEMBL58058 198686 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 501 6 2 6 6.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(-c2ccccc2)c1 10.1021/jm030528p
10505771 163354 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 506 12 1 4 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
CHEMBL419211 163354 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 506 12 1 4 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
11026025 202883 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 7 1 6 4.6 CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL62669 202883 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 7 1 6 4.6 CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10649122 9737 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 502 12 1 4 5.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)c(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL113400 9737 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 502 12 1 4 5.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)c(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10505771 163354 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 4 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL419211 163354 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 4 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
21041297 169605 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 510 12 2 9 3.4 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4436531 169605 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 510 12 2 9 3.4 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
71453357 81680 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 707 12 1 12 5.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163708 81680 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 707 12 1 12 5.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
159594 522 None 45 Rat Binding pIC50 = 8.8 8.8 -1 3
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1016/s0960-894x(98)00301-1
3487 522 None 45 Rat Binding pIC50 = 8.8 8.8 -1 3
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1016/s0960-894x(98)00301-1
CHEMBL9194 522 None 45 Rat Binding pIC50 = 8.8 8.8 -1 3
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1016/s0960-894x(98)00301-1
DB06199 522 None 45 Rat Binding pIC50 = 8.8 8.8 -1 3
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1016/s0960-894x(98)00301-1
44279303 107094 None 0 Human Binding pIC50 = 8.8 8.8 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 576 11 2 7 4.3 COCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL31592 107094 None 0 Human Binding pIC50 = 8.8 8.8 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 576 11 2 7 4.3 COCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
10302092 111335 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 532 12 1 7 3.7 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC 10.1021/jm970101g
CHEMBL326861 111335 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 532 12 1 7 3.7 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC 10.1021/jm970101g
10768903 12132 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 544 11 2 6 5.3 CCCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
CHEMBL1184133 12132 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 544 11 2 6 5.3 CCCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
CHEMBL334076 12132 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 544 11 2 6 5.3 CCCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
11733231 202842 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1cccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)c1 10.1021/jm010382z
CHEMBL62465 202842 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1cccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)c1 10.1021/jm010382z
9872534 176021 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 521 11 2 10 3.5 COc1ccccc1Oc1c(NS(=O)(=O)/C=C/c2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4590018 176021 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 521 11 2 10 3.5 COc1ccccc1Oc1c(NS(=O)(=O)/C=C/c2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.bmcl.2016.06.014
44439103 91949 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 859 27 2 14 5.3 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 10.1016/j.bmcl.2006.10.009
CHEMBL241460 91949 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 859 27 2 14 5.3 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 10.1016/j.bmcl.2006.10.009
67952994 82004 None 14 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 634 11 2 8 4.4 O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
CHEMBL2165334 82004 None 14 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 634 11 2 8 4.4 O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
19689505 58912 None 0 Pig Binding pIC50 = 8.8 8.8 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 639 11 1 8 6.5 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(-c2ccc(C)cc2)c(OCCOc2ncc(Br)cn2)n1 10.1016/s0960-894x(01)00682-5
CHEMBL168904 58912 None 0 Pig Binding pIC50 = 8.8 8.8 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 639 11 1 8 6.5 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(-c2ccc(C)cc2)c(OCCOc2ncc(Br)cn2)n1 10.1016/s0960-894x(01)00682-5
44334065 167820 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 429 5 1 5 4.7 COc1ccc([C@@H]2c3nc(C4CC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL430695 167820 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 429 5 1 5 4.7 COc1ccc([C@@H]2c3nc(C4CC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
10719367 98228 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)cc(OC)c2)cc1 10.1021/jm9606507
CHEMBL274359 98228 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)cc(OC)c2)cc1 10.1021/jm9606507
12286 947 None 36 Human Binding pIC50 = 8.8 8.8 1348 2
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
6433095 947 None 36 Human Binding pIC50 = 8.8 8.8 1348 2
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
CHEMBL109648 947 None 36 Human Binding pIC50 = 8.8 8.8 1348 2
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
DB06677 947 None 36 Human Binding pIC50 = 8.8 8.8 1348 2
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
22467237 85341 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 549 8 3 8 2.3 Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(CC(=O)O)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1007/s00044-004-0021-y
CHEMBL2261357 85341 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 549 8 3 8 2.3 Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(CC(=O)O)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1007/s00044-004-0021-y
71455063 81693 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 646 15 2 12 3.8 CCCCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
CHEMBL2163720 81693 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 646 15 2 12 3.8 CCCCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
21041267 82007 None 13 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 558 9 2 8 2.8 CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
CHEMBL2165337 82007 None 13 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 558 9 2 8 2.8 CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
10813261 60425 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL175129 60425 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
9955200 9330 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
CHEMBL11115 9330 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
10601668 98444 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)cc2OC)cc1 10.1021/jm9606507
CHEMBL275701 98444 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)cc2OC)cc1 10.1021/jm9606507
10973523 202859 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 537 7 1 8 4.2 COc1ccc(C2=C(C(=O)NS(C)(=O)=O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL62578 202859 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 537 7 1 8 4.2 COc1ccc(C2=C(C(=O)NS(C)(=O)=O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
11122785 202973 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 8 1 6 4.6 COCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL63057 202973 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 8 1 6 4.6 COCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10649546 108612 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 516 13 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCCCO1 10.1021/jm980217s
CHEMBL320569 108612 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 516 13 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCCCO1 10.1021/jm980217s
CHEMBL2304015 209469 None 0 Pig Binding pIC50 = 8.7 8.7 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O 10.1021/jm9600914
10029171 98763 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 505 6 2 7 3.0 Cc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL278109 98763 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 505 6 2 7 3.0 Cc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
11800804 161834 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 550 10 4 5 4.7 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N(C)C2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL414605 161834 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 550 10 4 5 4.7 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N(C)C2CCCCC2)nc1C(=O)O 10.1021/jm9505932
42630655 18405 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 557 11 2 7 5.5 CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1271586 18405 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 557 11 2 7 5.5 CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
10504475 206950 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 468 8 1 6 3.4 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)C)cc1 10.1021/jm9505369
CHEMBL9119 206950 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 468 8 1 6 3.4 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)C)cc1 10.1021/jm9505369
71456863 81688 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 680 14 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1016/j.bmcl.2016.06.014
CHEMBL2163716 81688 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 680 14 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1016/j.bmcl.2016.06.014
10971938 202974 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 424 7 1 5 5.6 CC(C)CCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL63058 202974 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 424 7 1 5 5.6 CC(C)CCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
44315008 102829 None 0 Pig Binding pIC50 = 8.7 8.7 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 665 13 5 5 4.7 CCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL305524 102829 None 0 Pig Binding pIC50 = 8.7 8.7 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 665 13 5 5 4.7 CCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
71453356 81663 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 554 13 2 10 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cccc(OC)c1 10.1021/jm3009103
CHEMBL2163691 81663 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 554 13 2 10 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cccc(OC)c1 10.1021/jm3009103
71456863 81688 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 680 14 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163716 81688 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 680 14 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
11827768 9873 None 0 Pig Binding pIC50 = 8.7 8.7 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncccn2)c1 10.1021/jm0102304
CHEMBL114201 9873 None 0 Pig Binding pIC50 = 8.7 8.7 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncccn2)c1 10.1021/jm0102304
44387543 60560 None 0 Pig Binding pIC50 = 8.7 8.7 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 759 9 1 9 8.1 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(Cl)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1.O=C1C2=C(CCCC2)c2ccccc21 10.1021/jm0102304
CHEMBL175931 60560 None 0 Pig Binding pIC50 = 8.7 8.7 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 759 9 1 9 8.1 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(Cl)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1.O=C1C2=C(CCCC2)c2ccccc21 10.1021/jm0102304
44334129 108552 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 459 8 1 5 5.5 CCCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL320208 108552 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 459 8 1 5 5.5 CCCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
10507467 8498 None 0 Rat Binding pIC50 = 8 8.0 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 580 12 1 7 4.5 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)Cc1ccccc1 10.1021/jm970101g
CHEMBL109408 8498 None 0 Rat Binding pIC50 = 8 8.0 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 580 12 1 7 4.5 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)Cc1ccccc1 10.1021/jm970101g
10118046 9434 None 0 Rat Binding pIC50 = 8 8.0 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 504 10 1 7 2.9 CCCS(=O)(=O)N(C)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
CHEMBL111728 9434 None 0 Rat Binding pIC50 = 8 8.0 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 504 10 1 7 2.9 CCCS(=O)(=O)N(C)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
10597575 6894 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 408 5 1 6 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCC2)cc1 10.1021/jm9606507
CHEMBL10843 6894 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 408 5 1 6 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCC2)cc1 10.1021/jm9606507
10671928 7274 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 467 5 1 7 4.4 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2nccc3ccccc23)cc1 10.1021/jm9606507
CHEMBL10860 7274 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 467 5 1 7 4.4 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2nccc3ccccc23)cc1 10.1021/jm9606507
10791988 8581 None 0 Rat Binding pIC50 = 8 8.0 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 516 13 1 6 4.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCOCC1 10.1021/jm980217s
CHEMBL109474 8581 None 0 Rat Binding pIC50 = 8 8.0 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 516 13 1 6 4.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCOCC1 10.1021/jm980217s
10792934 163911 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 10 2 6 5.6 CCc1cc(CC)c(NC(=O)CN2C[C@H](c3ccc4c(c3)OCO4)[C@@H](C(=O)O)[C@@H]2c2ccc(OC)cc2)c(CC)c1 10.1021/jm990170q
CHEMBL420729 163911 None 0 Human Binding pIC50 = 8 8.0 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 10 2 6 5.6 CCc1cc(CC)c(NC(=O)CN2C[C@H](c3ccc4c(c3)OCO4)[C@@H](C(=O)O)[C@@H]2c2ccc(OC)cc2)c(CC)c1 10.1021/jm990170q
9939960 175573 None 0 Human Binding pIC50 = 8 8.0 - 0
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 704 13 2 11 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)cc(C(=O)N2CCN(C)CC2)cc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
CHEMBL4579445 175573 None 0 Human Binding pIC50 = 8 8.0 - 0
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 704 13 2 11 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)cc(C(=O)N2CCN(C)CC2)cc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
127035070 136470 None 0 Human Binding pIC50 = 8 8.0 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 647 11 2 7 7.3 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735931 136470 None 0 Human Binding pIC50 = 8 8.0 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 647 11 2 7 7.3 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
127036865 137422 None 0 Human Binding pIC50 = 8 8.0 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 584 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753406 137422 None 0 Human Binding pIC50 = 8 8.0 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 584 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
9875246 120307 None 0 Pig Binding pIC50 = 8 8.0 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 733 15 2 12 6.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(SCCC(=O)O)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
CHEMBL352775 120307 None 0 Pig Binding pIC50 = 8 8.0 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 733 15 2 12 6.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(SCCC(=O)O)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
10696210 99546 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 483 6 2 9 3.7 CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
CHEMBL283535 99546 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 483 6 2 9 3.7 CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
44291884 172896 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 483 6 2 9 3.7 CC(=O)c1c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)ccc2c1OCO2 10.1021/jm9700068
CHEMBL45160 172896 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 483 6 2 9 3.7 CC(=O)c1c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)ccc2c1OCO2 10.1021/jm9700068
10671037 131442 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL273660 131442 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL369085 131442 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm9606507
10673756 203460 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 529 9 1 8 4.3 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN3CCCC3)c2)cc1 10.1021/jm980504w
CHEMBL65939 203460 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 529 9 1 8 4.3 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN3CCCC3)c2)cc1 10.1021/jm980504w
10475644 203130 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 392 5 1 6 3.2 COc1nc(Cl)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL6412 203130 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 392 5 1 6 3.2 COc1nc(Cl)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
10696210 99546 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 483 6 2 9 3.7 CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm000349x
CHEMBL283535 99546 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 483 6 2 9 3.7 CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm000349x
71456862 81681 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 651 12 1 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163709 81681 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 651 12 1 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
44291583 101388 None 0 Human Binding pIC50 = 8.0 8.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 500 8 3 9 2.9 COc1cc(OC)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(N)=O)c1 10.1021/jm9608366
CHEMBL297215 101388 None 0 Human Binding pIC50 = 8.0 8.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 500 8 3 9 2.9 COc1cc(OC)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(N)=O)c1 10.1021/jm9608366
44278215 99556 None 0 Human Binding pIC50 = 7 7.0 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 491 5 1 9 4.7 O=C(O)c1c(Sc2ccc3c(c2)OCO3)c2cc3c(cc2n1Cc1ccc2c(c1)OCO2)OCO3 10.1016/0960-894X(96)00232-6
CHEMBL283598 99556 None 0 Human Binding pIC50 = 7 7.0 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 491 5 1 9 4.7 O=C(O)c1c(Sc2ccc3c(c2)OCO3)c2cc3c(cc2n1Cc1ccc2c(c1)OCO2)OCO3 10.1016/0960-894X(96)00232-6
10841576 11441 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 620 11 2 6 6.3 CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1CC 10.1021/jm990171i
CHEMBL1180336 11441 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 620 11 2 6 6.3 CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1CC 10.1021/jm990171i
CHEMBL122673 11441 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 620 11 2 6 6.3 CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1CC 10.1021/jm990171i
CHEMBL94907 215912 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
CHEMBL2304010 209464 None 0 Pig Binding pIC50 = 7 7.0 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None CSC(C)(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Cl)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O 10.1021/jm9600914
10792316 168480 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 530 8 2 6 5.3 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C)cccc2C(C)C)cc1 10.1021/jm990170q
CHEMBL435185 168480 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 530 8 2 6 5.3 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C)cccc2C(C)C)cc1 10.1021/jm990170q
18738890 99145 None 0 Human Binding pIC50 = 7 7.0 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 548 7 1 8 4.5 COC(=O)c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)cn(C)c2c1 10.1016/s0960-894x(01)00660-6
CHEMBL281121 99145 None 0 Human Binding pIC50 = 7 7.0 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 548 7 1 8 4.5 COC(=O)c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)cn(C)c2c1 10.1016/s0960-894x(01)00660-6
23445498 206698 None 0 Human Binding pIC50 = 7 7.0 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 426 4 1 5 4.9 Cc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(96)00496-9
CHEMBL89688 206698 None 0 Human Binding pIC50 = 7 7.0 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 426 4 1 5 4.9 Cc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(96)00496-9
10265127 96834 None 2 Rat Binding pIC50 = 6 6.0 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1C 10.1021/jm00008a013
CHEMBL26522 96834 None 2 Rat Binding pIC50 = 6 6.0 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1C 10.1021/jm00008a013
CHEMBL315047 211184 None 0 Human Binding pIC50 = 6 6.0 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
44327659 109820 None 0 Human Binding pIC50 = 6 6.0 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 937 26 9 8 4.6 CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 10.1021/jm00015a003
CHEMBL323331 109820 None 0 Human Binding pIC50 = 6 6.0 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 937 26 9 8 4.6 CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 10.1021/jm00015a003
CHEMBL318020 211207 None 0 Human Binding pIC50 = 6 6.0 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
44316685 205046 None 1 Human Binding pIC50 = 6 6.0 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 266 3 1 4 2.4 Cc1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
CHEMBL77090 205046 None 1 Human Binding pIC50 = 6 6.0 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 266 3 1 4 2.4 Cc1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
10022291 112026 None 0 Rat Binding pIC50 = 6 6.0 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 374 9 1 3 5.1 O=C(O)CCC(C(=O)c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
CHEMBL328964 112026 None 0 Rat Binding pIC50 = 6 6.0 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 374 9 1 3 5.1 O=C(O)CCC(C(=O)c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
12060119 110389 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 441 7 2 6 3.9 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL324304 110389 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 441 7 2 6 3.9 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)cc1 10.1016/j.bmcl.2016.06.014
4568158 111405 None 1 Rat Binding pIC50 = 6 6.0 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 400 8 2 4 4.9 O=C(O)c1cc(-c2ccc(OCc3ccccc3)cc2OCc2ccccc2)[nH]n1 10.1021/jm9707131
CHEMBL327247 111405 None 1 Rat Binding pIC50 = 6 6.0 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 400 8 2 4 4.9 O=C(O)c1cc(-c2ccc(OCc3ccccc3)cc2OCc2ccccc2)[nH]n1 10.1021/jm9707131
CHEMBL315047 211184 None 0 Human Binding pIC50 = 6 6.0 - 0
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
10568280 203101 None 0 Human Binding pIC50 = 6 6.0 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 328 4 1 5 2.5 CN(C)c1cccc2c(S(=O)(=O)Nc3cnccn3)cccc12 10.1021/jm9604585
CHEMBL6399 203101 None 0 Human Binding pIC50 = 6 6.0 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 328 4 1 5 2.5 CN(C)c1cccc2c(S(=O)(=O)Nc3cnccn3)cccc12 10.1021/jm9604585
10553319 61066 None 0 Rat Binding pIC50 = 6 6.0 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 496 11 5 4 3.8 CCN(CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C)[nH]1 10.1021/jm950592+
CHEMBL176430 61066 None 0 Rat Binding pIC50 = 6 6.0 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 496 11 5 4 3.8 CCN(CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C)[nH]1 10.1021/jm950592+
10006086 121060 None 0 Pig Binding pIC50 = 5 5.0 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 498 9 2 5 4.6 COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
CHEMBL356916 121060 None 0 Pig Binding pIC50 = 5 5.0 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 498 9 2 5 4.6 COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
10381122 99195 None 0 Rat Binding pIC50 = 5 5.0 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3ccc(N)cc3c2)c1C 10.1021/jm00008a013
CHEMBL281427 99195 None 0 Rat Binding pIC50 = 5 5.0 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3ccc(N)cc3c2)c1C 10.1021/jm00008a013
44327466 96449 None 0 Human Binding pIC50 = 5 5.0 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 966 25 9 8 5.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(C)(C)C)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL262229 96449 None 0 Human Binding pIC50 = 5 5.0 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 966 25 9 8 5.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(C)(C)C)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
18617385 205210 None 0 Human Binding pIC50 = 5 5.0 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 286 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL78601 205210 None 0 Human Binding pIC50 = 5 5.0 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 286 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1C 10.1016/0960-894X(96)00441-6
127029201 137256 None 0 Human Binding pIC50 = 5 5.0 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 644 12 3 9 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3751994 137256 None 0 Human Binding pIC50 = 5 5.0 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 644 12 3 9 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
3080568 178843 None 33 Rat Binding pIC50 = 5 5.0 - 0
Displacement of endothelin-1 from ETA receptor in rat A10 cellsDisplacement of endothelin-1 from ETA receptor in rat A10 cells
ChEMBL 348 5 3 7 2.7 COC(=O)c1cc(O)cc(OC)c1Oc1cc(C)cc(O)c1C(=O)O 10.1021/np0102758
CHEMBL469424 178843 None 33 Rat Binding pIC50 = 5 5.0 - 0
Displacement of endothelin-1 from ETA receptor in rat A10 cellsDisplacement of endothelin-1 from ETA receptor in rat A10 cells
ChEMBL 348 5 3 7 2.7 COC(=O)c1cc(O)cc(OC)c1Oc1cc(C)cc(O)c1C(=O)O 10.1021/np0102758
9846065 170917 None 0 Human Binding pIC50 = 5 5.0 - 0
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 439 7 2 6 3.6 O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4455096 170917 None 0 Human Binding pIC50 = 5 5.0 - 0
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 439 7 2 6 3.6 O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
44276947 106849 None 0 Rat Binding pIC50 = 5 5.0 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 430 5 1 3 5.2 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(Cl)c(Cl)c3)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144803 106849 None 0 Rat Binding pIC50 = 5 5.0 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 430 5 1 3 5.2 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(Cl)c(Cl)c3)c2=O)c1 10.1016/s0960-894x(00)00232-8
44276907 106853 None 0 Rat Binding pIC50 = 5 5.0 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 376 4 1 4 3.6 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccccc1 10.1016/s0960-894x(00)00232-8
CHEMBL3144845 106853 None 0 Rat Binding pIC50 = 5 5.0 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 376 4 1 4 3.6 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccccc1 10.1016/s0960-894x(00)00232-8
10381122 99195 None 0 Rat Binding pIC50 = 5 5.0 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3ccc(N)cc3c2)c1C 10.1021/jm00004a012
CHEMBL281427 99195 None 0 Rat Binding pIC50 = 5 5.0 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3ccc(N)cc3c2)c1C 10.1021/jm00004a012
3765218 203419 None 1 Human Binding pIC50 = 5 5.0 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 419 4 1 4 4.2 Cc1nc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)ccc1Br 10.1021/jm9604585
CHEMBL6566 203419 None 1 Human Binding pIC50 = 5 5.0 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 419 4 1 4 4.2 Cc1nc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)ccc1Br 10.1021/jm9604585
44266649 98108 None 0 Human Binding pIC50 = 5 5.0 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 391 3 1 4 5.4 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(Cl)ccc2n1-c1ccccc1 10.1016/0960-894X(96)00170-9
CHEMBL273488 98108 None 0 Human Binding pIC50 = 5 5.0 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 391 3 1 4 5.4 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(Cl)ccc2n1-c1ccccc1 10.1016/0960-894X(96)00170-9
23445421 59928 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 454 6 1 5 5.0 Cc1ccc(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL173189 59928 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 454 6 1 5 5.0 Cc1ccc(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
10832763 168437 None 0 Human Binding pIC50 = 5.0 5.0 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 366 4 2 6 2.3 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1Br 10.1016/S0960-894X(97)00367-3
CHEMBL434983 168437 None 0 Human Binding pIC50 = 5.0 5.0 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 366 4 2 6 2.3 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1Br 10.1016/S0960-894X(97)00367-3
137649809 157385 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 583 10 2 7 5.9 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CCCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4078297 157385 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 583 10 2 7 5.9 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CCCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
10527774 183686 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 6 4.2 Cc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1021/jm9608366
CHEMBL48031 183686 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 6 4.2 Cc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1021/jm9608366
22998456 59792 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 514 8 1 8 4.9 CCCc1cc2c(cc1OCc1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00132-7
CHEMBL172666 59792 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 514 8 1 8 4.9 CCCc1cc2c(cc1OCc1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00132-7
9874379 60444 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 653 14 2 10 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL175268 60444 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 653 14 2 10 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
10718385 206809 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 450 7 1 6 2.4 C#CCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9040 206809 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 450 7 1 6 2.4 C#CCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
23445593 60233 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 440 6 1 5 4.7 Cc1ccc(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
CHEMBL174086 60233 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 440 6 1 5 4.7 Cc1ccc(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
10805820 203715 None 60 Human Binding pIC50 = 6.0 6.0 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 322 4 2 6 2.2 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1Cl 10.1016/S0960-894X(97)00367-3
CHEMBL67664 203715 None 60 Human Binding pIC50 = 6.0 6.0 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 322 4 2 6 2.2 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1Cl 10.1016/S0960-894X(97)00367-3
10812400 98377 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 427 9 1 6 3.7 CCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL275306 98377 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 427 9 1 6 3.7 CCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
44265853 206400 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 4 1 6 2.7 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)N2CCOCC2)cc1 10.1021/jm9505369
CHEMBL8776 206400 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 4 1 6 2.7 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)N2CCOCC2)cc1 10.1021/jm9505369
10854399 202998 None 41 Human Binding pIC50 = 6.0 6.0 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 336 4 1 7 2.3 COC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1016/S0960-894X(97)00367-3
CHEMBL63169 202998 None 41 Human Binding pIC50 = 6.0 6.0 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 336 4 1 7 2.3 COC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1016/S0960-894X(97)00367-3
10647020 61293 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1OC 10.1021/jm031041j
CHEMBL176696 61293 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1OC 10.1021/jm031041j
10647021 6972 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1OC 10.1021/jm9606507
CHEMBL10846 6972 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1OC 10.1021/jm9606507
10552548 98520 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OC)c2OC)cc1 10.1021/jm9606507
CHEMBL276252 98520 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OC)c2OC)cc1 10.1021/jm9606507
9934580 162928 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 474 6 1 8 3.6 COC(=O)c1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
CHEMBL417428 162928 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 474 6 1 8 3.6 COC(=O)c1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
127035757 136503 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 591 10 1 8 6.2 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736242 136503 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 591 10 1 8 6.2 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
76308472 85352 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 517 6 1 8 3.7 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C#N)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261600 85352 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 517 6 1 8 3.7 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C#N)ccc12 10.1007/s00044-004-0021-y
44320338 106972 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 490 7 2 6 5.0 O=C(O)c1ccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)cc1 10.1016/s0960-894x(00)00513-8
CHEMBL315087 106972 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 490 7 2 6 5.0 O=C(O)c1ccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)cc1 10.1016/s0960-894x(00)00513-8
44385162 61379 None 0 Human Binding pIC50 = 8.0 8.0 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 533 10 2 10 3.3 C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL176963 61379 None 0 Human Binding pIC50 = 8.0 8.0 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 533 10 2 10 3.3 C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10697633 60332 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 10 5 5 4.4 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL174448 60332 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 10 5 5 4.4 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
10697633 60332 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 536 10 5 5 4.4 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL174448 60332 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 536 10 5 5 4.4 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
10551548 127816 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 450 7 1 5 5.0 COc1ccc(C(=O)/C(Cc2ccc(Cl)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL366442 127816 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 450 7 1 5 5.0 COc1ccc(C(=O)/C(Cc2ccc(Cl)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
11732966 203169 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 444 5 1 5 5.6 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(C(C)C)cc32)cc1 10.1021/jm031041j
CHEMBL64244 203169 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 444 5 1 5 5.6 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(C(C)C)cc32)cc1 10.1021/jm031041j
CHEMBL302776 210913 None 0 Pig Binding pIC50 = 7.0 7.0 - 0
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00089a028
22616262 205537 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 366 3 1 4 3.7 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80980 205537 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 366 3 1 4 3.7 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1Br 10.1016/0960-894X(96)00441-6
18617351 104107 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL309397 104107 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1Br 10.1016/0960-894X(96)00441-6
10433234 205445 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 436 5 1 4 4.3 CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80342 205445 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 436 5 1 4 4.3 CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
11744509 5428 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 450 5 1 6 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 10.1021/jm9606507
CHEMBL10733 5428 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 450 5 1 6 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 10.1021/jm9606507
11732966 203169 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 444 5 1 5 5.6 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(C(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL64244 203169 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 444 5 1 5 5.6 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(C(C)C)cc32)cc1 10.1021/jm010382z
54587165 60307 None 0 Pig Binding pIC50 = 7.0 7.0 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 675 15 5 4 5.9 CCCCCC[C@@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL1744023 60307 None 0 Pig Binding pIC50 = 7.0 7.0 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 675 15 5 4 5.9 CCCCCC[C@@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
44293932 163144 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@H](c1cccc(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL417903 163144 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@H](c1cccc(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
15304942 164428 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 394 9 1 4 5.5 Cc1ccccc1C(CCC(=O)O)C(=O)c1cccc(OCc2ccsc2)c1 10.1021/jm9707131
CHEMBL421365 164428 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 394 9 1 4 5.5 Cc1ccccc1C(CCC(=O)O)C(=O)c1cccc(OCc2ccsc2)c1 10.1021/jm9707131
44213279 106846 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 456 6 1 5 4.2 COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144737 106846 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 456 6 1 5 4.2 COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
10554748 60072 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 552 10 6 6 3.3 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(O)CC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL173826 60072 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 552 10 6 6 3.3 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(O)CC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL335143 211544 None 0 Pig Binding pIC50 = 7.0 7.0 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44382975 120331 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 596 11 4 7 3.7 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCc1nc(C(=O)O)cs1 10.1016/0960-894X(95)00144-I
CHEMBL352929 120331 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 596 11 4 7 3.7 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCc1nc(C(=O)O)cs1 10.1016/0960-894X(95)00144-I
10440821 207536 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 918 24 9 8 4.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c(C)c(C)c(C)c(C)c1C)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL94689 207536 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 918 24 9 8 4.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c(C)c(C)c(C)c(C)c1C)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10620470 111517 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 391 7 1 5 4.8 COc1cccc(/C(=C\c2cc(OCc3ccsc3)ccc2C#N)C(=O)O)c1 10.1021/jm970847e
CHEMBL327861 111517 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 391 7 1 5 4.8 COc1cccc(/C(=C\c2cc(OCc3ccsc3)ccc2C#N)C(=O)O)c1 10.1021/jm970847e
44293915 192544 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 507 9 1 8 4.4 CCOc1ccc2c(c1)[C@H](c1cc(OC)c(OC)c(OC)c1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL52110 192544 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 507 9 1 8 4.4 CCOc1ccc2c(c1)[C@H](c1cc(OC)c(OC)c(OC)c1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
44291495 11231 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 6 2 9 3.6 Cc1noc(NS(=O)(=O)c2ccsc2/C(Cc2ccc3c(c2)OCO3)=N\O)c1Cl 10.1021/jm9700068
CHEMBL1178832 11231 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 6 2 9 3.6 Cc1noc(NS(=O)(=O)c2ccsc2/C(Cc2ccc3c(c2)OCO3)=N\O)c1Cl 10.1021/jm9700068
CHEMBL45351 11231 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 6 2 9 3.6 Cc1noc(NS(=O)(=O)c2ccsc2/C(Cc2ccc3c(c2)OCO3)=N\O)c1Cl 10.1021/jm9700068
44266565 98232 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 417 5 1 6 4.7 COc1ccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OC)cc23)cc1 10.1016/0960-894X(96)00170-9
CHEMBL274370 98232 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 417 5 1 6 4.7 COc1ccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OC)cc23)cc1 10.1016/0960-894X(96)00170-9
44311225 204705 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 581 11 1 10 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)c1ccoc1 10.1016/S0960-894X(97)00400-9
CHEMBL74118 204705 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 581 11 1 10 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)c1ccoc1 10.1016/S0960-894X(97)00400-9
13044638 85836 None 22 Human Binding pIC50 = 5.0 5.0 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 206 2 1 3 2.4 COc1cccc2oc(C(=O)O)c(C)c12 10.1007/s00044-013-0542-3
CHEMBL2296888 85836 None 22 Human Binding pIC50 = 5.0 5.0 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 206 2 1 3 2.4 COc1cccc2oc(C(=O)O)c(C)c12 10.1007/s00044-013-0542-3
CHEMBL269428 210785 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10769177 112910 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.2 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCOC)cc1 10.1021/jm990170q
CHEMBL331066 112910 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.2 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCOC)cc1 10.1021/jm990170q
127026338 137402 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 616 11 3 7 5.9 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753277 137402 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 616 11 3 7 5.9 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
120533 101628 None 9 Rat Binding pIC50 = 5.0 5.0 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 379 3 2 5 2.0 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1I 10.1016/s0960-894x(00)00366-8
CHEMBL298976 101628 None 9 Rat Binding pIC50 = 5.0 5.0 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 379 3 2 5 2.0 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1I 10.1016/s0960-894x(00)00366-8
10674532 168586 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 567 10 4 5 5.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C(C)C)s1 10.1021/jm950591h
CHEMBL435894 168586 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 567 10 4 5 5.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C(C)C)s1 10.1021/jm950591h
10452089 4563 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 375 3 0 5 4.1 COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 10.1016/S0960-894X(96)00551-3
CHEMBL102494 4563 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 375 3 0 5 4.1 COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 10.1016/S0960-894X(96)00551-3
10095637 49965 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 457 9 1 5 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00186-W
CHEMBL15689 49965 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 457 9 1 5 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00186-W
19385674 98587 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 715 13 1 7 8.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br 10.1016/0960-894X(95)00186-W
CHEMBL276819 98587 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 715 13 1 7 8.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br 10.1016/0960-894X(95)00186-W
19385674 98587 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 715 13 1 7 8.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br 10.1021/jm058225d
CHEMBL276819 98587 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 715 13 1 7 8.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br 10.1021/jm058225d
44266538 5463 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 371 4 1 4 4.8 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccccc1 10.1016/0960-894X(96)00170-9
CHEMBL10750 5463 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 371 4 1 4 4.8 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccccc1 10.1016/0960-894X(96)00170-9
11798999 207583 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 7 1 6 3.8 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)(C)C)cc1 10.1021/jm9505369
CHEMBL9495 207583 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 7 1 6 3.8 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)(C)C)cc1 10.1021/jm9505369
71460536 81684 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 589 11 1 12 3.1 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163712 81684 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 589 11 1 12 3.1 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
10669120 207443 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1[C@H](CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm9707131
CHEMBL94141 207443 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1[C@H](CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm9707131
CHEMBL444274 213929 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/S0960-894X(01)81219-1
23445366 106181 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 482 7 1 5 6.2 Cc1cc(CCC(C)C)ccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL313801 106181 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 482 7 1 5 6.2 Cc1cc(CCC(C)C)ccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
52949197 18422 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 555 10 2 7 5.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271746 18422 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 555 10 2 7 5.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
10694591 9224 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 444 6 1 6 4.6 CC(C)Oc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL11064 9224 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 444 6 1 6 4.6 CC(C)Oc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
18184194 130560 None 0 Human Binding pIC50 = 6.9 6.9 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 712 15 2 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL368107 130560 None 0 Human Binding pIC50 = 6.9 6.9 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 712 15 2 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
9998577 98100 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 1 5 3.6 CCc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL27344 98100 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 1 5 3.6 CCc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL327350 211288 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
18184228 61351 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 604 13 2 9 4.6 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL176749 61351 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 604 13 2 9 4.6 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
10342643 5155 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm9606507
CHEMBL10588 5155 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm9606507
10791694 98198 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2OC)cc1 10.1021/jm9606507
CHEMBL274175 98198 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2OC)cc1 10.1021/jm9606507
11058202 202821 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 388 4 1 5 4.4 CC(C)Oc1ccc2c(c1)C(Cl)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL62374 202821 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 388 4 1 5 4.4 CC(C)Oc1ccc2c(c1)C(Cl)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
11799636 109262 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCCO1 10.1021/jm980217s
CHEMBL321831 109262 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCCO1 10.1021/jm980217s
10626646 16444 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCc1cccc(CCC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL123305 16444 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCc1cccc(CCC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
10224745 112688 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 432 5 2 6 2.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1016/j.bmcl.2016.06.014
CHEMBL330425 112688 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 432 5 2 6 2.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1016/j.bmcl.2016.06.014
44459272 91238 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 491 6 2 7 2.6 Cn1cc(C(C(=O)NS(=O)(=O)c2ccccc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL24015 91238 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 491 6 2 7 2.6 Cn1cc(C(C(=O)NS(=O)(=O)c2ccccc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
22010352 117624 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 404 10 1 4 5.5 CC(=O)c1ccc(OCc2ccccc2)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
CHEMBL3400984 117624 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 404 10 1 4 5.5 CC(=O)c1ccc(OCc2ccccc2)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
10693270 60067 None 1 Rat Binding pIC50 = 7.9 7.9 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL172144 60067 None 1 Rat Binding pIC50 = 7.9 7.9 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL173792 60067 None 1 Rat Binding pIC50 = 7.9 7.9 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
44295257 14626 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 538 10 1 9 4.8 COc1cc(F)ccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 10.1016/s0960-894x(98)00301-1
CHEMBL1205063 14626 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 538 10 1 9 4.8 COc1cc(F)ccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 10.1016/s0960-894x(98)00301-1
CHEMBL48458 14626 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 538 10 1 9 4.8 COc1cc(F)ccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 10.1016/s0960-894x(98)00301-1
9915095 101528 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 535 8 2 8 3.4 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(C(=O)C(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL298212 101528 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 535 8 2 8 3.4 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(C(=O)C(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10864618 113320 None 0 Pig Binding pIC50 = 7.9 7.9 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 556 11 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2nccs2)c1 10.1021/jm0102304
CHEMBL331580 113320 None 0 Pig Binding pIC50 = 7.9 7.9 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 556 11 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2nccs2)c1 10.1021/jm0102304
10599879 101274 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 6 4.2 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
CHEMBL296326 101274 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 6 4.2 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
10233400 128683 None 0 Human Binding pIC50 = 7.9 7.9 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccncc1 10.1016/s0960-894x(02)01084-3
CHEMBL366885 128683 None 0 Human Binding pIC50 = 7.9 7.9 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccncc1 10.1016/s0960-894x(02)01084-3
10304227 130006 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 603 10 2 13 4.2 C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL367686 130006 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 603 10 2 13 4.2 C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10745668 204375 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 572 10 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN3CCN(C)CC3)c2)cc1 10.1021/jm980504w
CHEMBL71787 204375 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 572 10 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN3CCN(C)CC3)c2)cc1 10.1021/jm980504w
CHEMBL148751 208782 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
CHEMBL137659 208744 None 0 Pig Binding pIC50 = 7.9 7.9 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
44302513 102716 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 553 9 3 9 5.1 CCCc1c(O)c(C(C)=O)cc(C(C)=O)c1NC(=O)c1sc(C)cc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL304860 102716 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 553 9 3 9 5.1 CCCc1c(O)c(C(C)=O)cc(C(C)=O)c1NC(=O)c1sc(C)cc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
10623465 203745 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of specific binding of [125-I] ET-1 to human Endothelin A receptorInhibition of specific binding of [125-I] ET-1 to human Endothelin A receptor
ChEMBL 450 6 1 6 3.7 CCN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 10.1021/jm9604585
CHEMBL6785 203745 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of specific binding of [125-I] ET-1 to human Endothelin A receptorInhibition of specific binding of [125-I] ET-1 to human Endothelin A receptor
ChEMBL 450 6 1 6 3.7 CCN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 10.1021/jm9604585
18617303 105793 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1cccc(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
CHEMBL312685 105793 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1cccc(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
15453179 205479 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80538 205479 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Br 10.1016/0960-894X(96)00441-6
44293866 101620 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 461 8 1 6 4.8 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL298922 101620 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 461 8 1 6 4.8 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL292901 210885 None 0 Pig Binding pIC50 = 6.9 6.9 - 0
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
10627333 60381 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 595 11 4 8 4.2 COC(=O)C1(NC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc2cn(C)c3ccccc23)c2nc(C(=O)O)c(C)o2)CCCCC1 10.1021/jm950592+
CHEMBL174818 60381 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 595 11 4 8 4.2 COC(=O)C1(NC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc2cn(C)c3ccccc23)c2nc(C(=O)O)c(C)o2)CCCCC1 10.1021/jm950592+
CHEMBL335416 211545 None 0 Pig Binding pIC50 = 6.9 6.9 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CCCC[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
10961510 202833 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 458 7 1 4 6.6 COc1ccc(C2=C(C(=O)O)C(c3ccc(C(C)C)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
CHEMBL62425 202833 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 458 7 1 4 6.6 COc1ccc(C2=C(C(=O)O)C(c3ccc(C(C)C)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
44371449 49376 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c(OC)c1 10.1016/s0960-894x(99)00040-2
CHEMBL156404 49376 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c(OC)c1 10.1016/s0960-894x(99)00040-2
44371460 49528 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 469 5 1 7 4.9 COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2oc3ccccc3c21 10.1016/s0960-894x(99)00040-2
CHEMBL156539 49528 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 469 5 1 7 4.9 COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2oc3ccccc3c21 10.1016/s0960-894x(99)00040-2
10961510 202833 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 458 7 1 4 6.6 COc1ccc(C2=C(C(=O)O)C(c3ccc(C(C)C)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL62425 202833 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 458 7 1 4 6.6 COc1ccc(C2=C(C(=O)O)C(c3ccc(C(C)C)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
11733232 202862 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1cccc2c1C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL62586 202862 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1cccc2c1C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL412460 212989 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
23445317 100544 None 0 Human Binding pIC50 = 5.9 5.9 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 456 5 1 7 4.1 Cc1cccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/S0960-894X(97)00367-3
CHEMBL291404 100544 None 0 Human Binding pIC50 = 5.9 5.9 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 456 5 1 7 4.1 Cc1cccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/S0960-894X(97)00367-3
23445507 59758 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 442 6 1 6 4.5 Cc1ccc(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00132-7
CHEMBL172538 59758 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 442 6 1 6 4.5 Cc1ccc(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00132-7
44298956 195678 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 489 9 1 7 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1OC)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
CHEMBL55666 195678 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 489 9 1 7 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1OC)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
10041979 99370 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 325 6 3 6 1.6 Cc1noc(NS(=O)(=O)c2ccc(NCC(=O)O)cc2)c1C 10.1021/jm00008a013
CHEMBL282557 99370 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 325 6 3 6 1.6 Cc1noc(NS(=O)(=O)c2ccc(NCC(=O)O)cc2)c1C 10.1021/jm00008a013
44266654 98070 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 387 4 1 5 4.7 COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccccc1 10.1016/0960-894X(96)00170-9
CHEMBL273258 98070 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 387 4 1 5 4.7 COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccccc1 10.1016/0960-894X(96)00170-9
44385576 131375 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 539 10 1 10 3.4 C#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL368929 131375 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 539 10 1 10 3.4 C#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
11799440 206974 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 11 1 6 4.3 CCCN(CCC)C(=O)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9132 206974 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 11 1 6 4.3 CCCN(CCC)C(=O)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
52949197 18422 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 555 10 2 7 5.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1271746 18422 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 555 10 2 7 5.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
10531506 12114 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 592 9 2 6 5.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2cc(C)ccc2C)cc1 10.1021/jm990171i
CHEMBL1184076 12114 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 592 9 2 6 5.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2cc(C)ccc2C)cc1 10.1021/jm990171i
CHEMBL331548 12114 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 592 9 2 6 5.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2cc(C)ccc2C)cc1 10.1021/jm990171i
10650546 12118 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 562 7 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2c3ccccc3-c3ccccc32)cc1 10.1021/jm990171i
CHEMBL1184091 12118 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 562 7 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2c3ccccc3-c3ccccc32)cc1 10.1021/jm990171i
CHEMBL332144 12118 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 562 7 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2c3ccccc3-c3ccccc32)cc1 10.1021/jm990171i
10814743 179369 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 484 6 1 9 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C2(Cc3ccc4c(c3)OCO4)OCCO2)c1Cl 10.1021/jm9700068
CHEMBL47383 179369 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 484 6 1 9 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C2(Cc3ccc4c(c3)OCO4)OCCO2)c1Cl 10.1021/jm9700068
10623888 163156 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 461 8 1 6 3.4 CCCCS(=O)(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL417971 163156 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 461 8 1 6 3.4 CCCCS(=O)(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10281573 59973 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 574 9 2 9 4.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccncc2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL173358 59973 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 574 9 2 9 4.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccncc2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
44385586 61660 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 531 10 1 9 4.7 C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL177143 61660 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 531 10 1 9 4.7 C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10645066 97192 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Br)cn3)cccc12 10.1021/jm9604585
CHEMBL268339 97192 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Br)cn3)cccc12 10.1021/jm9604585
11792960 161913 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 361 4 1 4 3.8 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)nc3)cccc12 10.1021/jm9604585
CHEMBL415292 161913 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 361 4 1 4 3.8 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)nc3)cccc12 10.1021/jm9604585
10593411 203445 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 342 4 1 5 2.8 Cc1cnc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)cn1 10.1021/jm9604585
CHEMBL6583 203445 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 342 4 1 5 2.8 Cc1cnc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)cn1 10.1021/jm9604585
127029202 137326 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 598 11 3 7 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752680 137326 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 598 11 3 7 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
10122495 30869 None 0 Human Binding pIC50 = 5.9 5.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 665 12 1 10 6.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOCc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL139734 30869 None 0 Human Binding pIC50 = 5.9 5.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 665 12 1 10 6.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOCc1ccccc1 10.1016/s0960-894x(02)01084-3
44384177 120291 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 506 6 1 8 4.6 Cc1noc(NS(=O)(=O)c2ccsc2COc2cc3c(cc2Cl)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
CHEMBL352657 120291 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 506 6 1 8 4.6 Cc1noc(NS(=O)(=O)c2ccsc2COc2cc3c(cc2Cl)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
10550033 101365 None 0 Human Binding pIC50 = 5.9 5.9 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 419 5 2 9 2.9 Cc1nnc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)s1 10.1021/jm9608366
CHEMBL297048 101365 None 0 Human Binding pIC50 = 5.9 5.9 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 419 5 2 9 2.9 Cc1nnc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)s1 10.1021/jm9608366
10626521 60073 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 11 4 6 5.1 CCn1cc(C[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)c2nc(C(=O)O)c(C)o2)c2ccccc21 10.1021/jm950592+
CHEMBL173833 60073 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 11 4 6 5.1 CCn1cc(C[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)c2nc(C(=O)O)c(C)o2)c2ccccc21 10.1021/jm950592+
CHEMBL94983 215914 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10671036 6655 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)c(OC)c1 10.1021/jm9606507
CHEMBL10834 6655 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)c(OC)c1 10.1021/jm9606507
9932004 98175 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 422 5 1 6 4.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCCC2)cc1 10.1021/jm9606507
CHEMBL273948 98175 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 422 5 1 6 4.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCCC2)cc1 10.1021/jm9606507
10816110 108564 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 532 13 1 7 4.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OC(C)C(C)O1 10.1021/jm980217s
CHEMBL320254 108564 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 532 13 1 7 4.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OC(C)C(C)O1 10.1021/jm980217s
44314619 204684 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 631 12 5 4 4.5 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
CHEMBL73925 204684 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 631 12 5 4 4.5 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
10209324 14488 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 546 8 1 7 6.2 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 10.1039/C4MD00499J
CHEMBL12013 14488 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 546 8 1 7 6.2 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 10.1039/C4MD00499J
10740439 172746 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 412 5 2 7 3.5 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)nc1 10.1021/jm9608366
CHEMBL45087 172746 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 412 5 2 7 3.5 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)nc1 10.1021/jm9608366
135415889 59267 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 587 10 2 13 3.6 C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL170401 59267 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 587 10 2 13 3.6 C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10281943 60062 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 589 10 1 10 4.9 COCC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL173743 60062 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 589 10 1 10 4.9 COCC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10212088 96694 None 0 Human Binding pIC50 = 7.9 7.9 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 688 12 2 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL264035 96694 None 0 Human Binding pIC50 = 7.9 7.9 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 688 12 2 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL2370830 209927 None 0 Pig Binding pIC50 = 7.9 7.9 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
42630531 18486 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 543 9 2 7 5.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OC(C)C)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1272299 18486 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 543 9 2 7 5.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OC(C)C)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
10768904 12128 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 544 10 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)C)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL1184117 12128 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 544 10 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)C)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL333034 12128 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 544 10 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)C)c2ccccc2)cc1 10.1021/jm990171i
10385400 96205 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 385 4 1 5 3.4 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCC4=O)cccc23)c1C 10.1021/jm00008a013
CHEMBL26079 96205 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 385 4 1 5 3.4 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCC4=O)cccc23)c1C 10.1021/jm00008a013
10426828 98143 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 331 4 2 5 3.3 CNc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL27370 98143 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 331 4 2 5 3.3 CNc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
10361993 99564 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 373 5 1 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL283652 99564 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 373 5 1 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C(C)C)cccc23)c1C 10.1021/jm00008a013
11103224 202651 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 510 14 1 6 7.3 CCCCCCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL61406 202651 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 510 14 1 6 7.3 CCCCCCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
11826847 202917 None 1 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccccc1OC)O2 10.1021/jm010382z
CHEMBL62814 202917 None 1 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccccc1OC)O2 10.1021/jm010382z
10837347 8867 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 452 8 1 5 3.3 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL109736 8867 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 452 8 1 5 3.3 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10298764 9852 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 468 8 1 6 3.2 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL114084 9852 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 468 8 1 6 3.2 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL317064 211195 None 15 Human Binding pIC50 = 6.9 6.9 - 1
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
44266552 4511 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10218 4511 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL337567 211596 None 0 Pig Binding pIC50 = 6.9 6.9 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CSCC[C@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C(C)C)NC1=O 10.1021/jm00021a021
CHEMBL150719 208789 None 0 Human Binding pIC50 = 6.9 6.9 - 0
The inhibitory constant was evaluated against Endothelin A receptor in rabbit renal artery tissueThe inhibitory constant was evaluated against Endothelin A receptor in rabbit renal artery tissue
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
44371421 51433 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 459 5 1 5 5.8 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3Cl)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL158204 51433 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 459 5 1 5 5.8 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3Cl)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
10067008 97798 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc2c1 10.1021/jm00008a013
CHEMBL27187 97798 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc2c1 10.1021/jm00008a013
10423091 99969 None 3 Rat Binding pIC50 = 5.9 5.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2cccc(N)c2)c1C 10.1021/jm00008a013
CHEMBL286521 99969 None 3 Rat Binding pIC50 = 5.9 5.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2cccc(N)c2)c1C 10.1021/jm00008a013
10552007 6321 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 462 8 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c(OC)c(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL10819 6321 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 462 8 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c(OC)c(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
10961720 203482 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 472 6 1 5 6.3 CC(C)Oc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(C(C)C)cc1)O2 10.1021/jm010382z
CHEMBL66094 203482 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 472 6 1 5 6.3 CC(C)Oc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(C(C)C)cc1)O2 10.1021/jm010382z
10577405 9650 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 14 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1C(C)(C)CCCC 10.1021/jm980217s
CHEMBL112777 9650 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 14 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1C(C)(C)CCCC 10.1021/jm980217s
10573912 111620 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 415 7 1 5 5.5 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1ccccc1Cl 10.1021/jm970847e
CHEMBL328444 111620 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 415 7 1 5 5.5 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1ccccc1Cl 10.1021/jm970847e
10524954 207058 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 399 6 1 5 4.5 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1/C=C(/C(=O)O)c1ccccc1 10.1021/jm970847e
CHEMBL91741 207058 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 399 6 1 5 4.5 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1/C=C(/C(=O)O)c1ccccc1 10.1021/jm970847e
44298343 101791 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 485 9 1 7 5.8 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC#N)c1 10.1016/s0960-894x(00)00366-8
CHEMBL300066 101791 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 485 9 1 7 5.8 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC#N)c1 10.1016/s0960-894x(00)00366-8
44298279 194949 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 502 10 1 7 5.8 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(C)=O)c1 10.1016/s0960-894x(00)00366-8
CHEMBL54274 194949 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 502 10 1 7 5.8 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(C)=O)c1 10.1016/s0960-894x(00)00366-8
155560344 176501 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting methodDisplacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting method
ChEMBL 641 12 4 7 4.8 CCCC[C@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/acs.jmedchem.5b01781
CHEMBL4568795 176501 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting methodDisplacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting method
ChEMBL 641 12 4 7 4.8 CCCC[C@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/acs.jmedchem.5b01781
CHEMBL4596821 176501 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting methodDisplacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting method
ChEMBL 641 12 4 7 4.8 CCCC[C@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/acs.jmedchem.5b01781
155535325 172007 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)cc(-c2ncccn2)cc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4471434 172007 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)cc(-c2ncccn2)cc1OCCO 10.1016/j.bmcl.2016.06.014
44276946 106844 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 440 5 1 5 4.2 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3cc(Cl)c4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144735 106844 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 440 5 1 5 4.2 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3cc(Cl)c4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
44309897 204629 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 469 5 1 7 4.9 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccc4c(c3)OCO4)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(97)10151-2
CHEMBL73506 204629 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 469 5 1 7 4.9 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccc4c(c3)OCO4)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(97)10151-2
44298988 100717 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 459 8 1 6 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
CHEMBL292580 100717 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 459 8 1 6 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
10067008 97798 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc2c1 10.1021/jm00004a012
CHEMBL27187 97798 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc2c1 10.1021/jm00004a012
10423091 99969 None 3 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2cccc(N)c2)c1C 10.1021/jm00004a012
CHEMBL286521 99969 None 3 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2cccc(N)c2)c1C 10.1021/jm00004a012
44266595 4391 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 507 6 1 7 6.0 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(OCc3ccccc3)ccc2n1-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10136 4391 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 507 6 1 7 6.0 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(OCc3ccccc3)ccc2n1-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
10337668 102135 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 346 4 2 5 2.9 Cc1noc(NS(=O)(=O)c2cccc3c(C(=O)O)cccc23)c1C 10.1021/jm00029a001
CHEMBL30246 102135 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 346 4 2 5 2.9 Cc1noc(NS(=O)(=O)c2cccc3c(C(=O)O)cccc23)c1C 10.1021/jm00029a001
10337668 102135 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 346 4 2 5 2.9 Cc1noc(NS(=O)(=O)c2cccc3c(C(=O)O)cccc23)c1C 10.1021/jm00008a013
CHEMBL30246 102135 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 346 4 2 5 2.9 Cc1noc(NS(=O)(=O)c2cccc3c(C(=O)O)cccc23)c1C 10.1021/jm00008a013
160743 204488 None 23 Rat Binding pIC50 = 4.9 4.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 309 4 2 5 2.1 CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00008a013
CHEMBL725 204488 None 23 Rat Binding pIC50 = 4.9 4.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 309 4 2 5 2.1 CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00008a013
18617314 205230 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 334 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL78734 205230 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 334 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL38071 212270 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
44213959 170366 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 592 11 3 9 5.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(=O)Nc2ccccc2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4447655 170366 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 592 11 3 9 5.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(=O)Nc2ccccc2)nc1OCCO 10.1016/j.bmcl.2016.06.014
127026027 137271 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 628 12 3 8 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752145 137271 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 628 12 3 8 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL1791280 208918 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00152-J
10816667 11442 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 558 9 2 6 5.6 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)(C)C)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL1180341 11442 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 558 9 2 6 5.6 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)(C)C)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL122933 11442 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 558 9 2 6 5.6 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)(C)C)c2ccccc2)cc1 10.1021/jm990171i
9853680 98646 None 0 Human Binding pIC50 = 5.9 5.9 - 1
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 771 17 2 14 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL277275 98646 None 0 Human Binding pIC50 = 5.9 5.9 - 1
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 771 17 2 14 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
10576378 101121 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 471 6 2 7 3.9 COc1ccccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1021/jm9608366
CHEMBL295207 101121 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 471 6 2 7 3.9 COc1ccccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1021/jm9608366
CHEMBL170229 208840 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)N1CCCCCC1)C(=O)O 10.1016/0960-894X(95)00144-I
23445219 112473 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 428 5 1 6 4.3 COc1cccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/S0960-894X(96)00496-9
CHEMBL329861 112473 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 428 5 1 6 4.3 COc1cccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/S0960-894X(96)00496-9
44386163 60378 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 577 14 2 10 3.4 CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL174781 60378 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 577 14 2 10 3.4 CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
23445537 61143 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 514 8 1 8 4.9 CCCc1cc2c(cc1OCc1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00132-7
CHEMBL176538 61143 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 514 8 1 8 4.9 CCCc1cc2c(cc1OCc1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00132-7
10766067 9736 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 452 8 1 5 3.3 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL113379 9736 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 452 8 1 5 3.3 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
127035069 136397 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 663 11 2 8 7.7 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735300 136397 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 663 11 2 8 7.7 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10792785 166721 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 3 6 5.0 CCOC(=O)c1nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)oc1C 10.1021/jm950592+
CHEMBL428298 166721 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 3 6 5.0 CCOC(=O)c1nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)oc1C 10.1021/jm950592+
9831527 129480 None 0 Human Binding pIC50 = 5.9 5.9 - 1
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 698 14 2 12 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL367274 129480 None 0 Human Binding pIC50 = 5.9 5.9 - 1
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 698 14 2 12 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
10189776 60055 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 651 11 1 10 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL173689 60055 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 651 11 1 10 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOc1ccccc1 10.1016/s0960-894x(02)01084-3
10743478 109266 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 484 12 1 4 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm031041j
CHEMBL321852 109266 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 484 12 1 4 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm031041j
10504389 130672 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 466 7 1 5 5.5 COc1ccc(C(=O)/C(Cc2cccc3ccccc23)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL368270 130672 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 466 7 1 5 5.5 COc1ccc(C(=O)/C(Cc2cccc3ccccc23)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
10505209 9315 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 490 6 1 9 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL11106 9315 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 490 6 1 9 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm9606507
10742841 97347 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 466 5 1 6 5.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3ccccc3c2)cc1 10.1021/jm9606507
CHEMBL269453 97347 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 466 5 1 6 5.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3ccccc3c2)cc1 10.1021/jm9606507
44314645 172670 None 0 Pig Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 601 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC1CC1)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL449962 172670 None 0 Pig Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 601 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC1CC1)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
10743478 109266 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 484 12 1 4 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL321852 109266 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 484 12 1 4 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10166561 10062 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 562 9 2 8 5.4 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 10.1039/C4MD00499J
CHEMBL11528 10062 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 562 9 2 8 5.4 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 10.1039/C4MD00499J
44214320 85348 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 510 6 1 7 4.0 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(F)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261364 85348 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 510 6 1 7 4.0 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(F)ccc12 10.1007/s00044-004-0021-y
10240093 81685 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 603 12 1 12 3.5 CCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
CHEMBL2163713 81685 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 603 12 1 12 3.5 CCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
71458721 81699 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 642 14 2 10 4.6 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(C2CC2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163726 81699 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 642 14 2 10 4.6 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(C2CC2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
10812894 120274 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 437 7 1 6 4.7 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
CHEMBL352536 120274 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 437 7 1 6 4.7 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
17869371 14787 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 478 8 1 7 4.8 COc1ccc(C(=O)/C(Cc2ccc(OC)c(F)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1206716 14787 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 478 8 1 7 4.8 COc1ccc(C(=O)/C(Cc2ccc(OC)c(F)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL299521 14787 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 478 8 1 7 4.8 COc1ccc(C(=O)/C(Cc2ccc(OC)c(F)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
44293417 187334 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 563 11 2 8 4.9 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(C)(C)C(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL49312 187334 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 563 11 2 8 4.9 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(C)(C)C(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
443289 710 None 47 Rat Binding pIC50 = 7.9 7.9 -2 3
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL None None None None 10.1021/jm9707131
997 710 None 47 Rat Binding pIC50 = 7.9 7.9 -2 3
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL None None None None 10.1021/jm9707131
CHEMBL314691 710 None 47 Rat Binding pIC50 = 7.9 7.9 -2 3
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL None None None None 10.1021/jm9707131
DB12054 710 None 47 Rat Binding pIC50 = 7.9 7.9 -2 3
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL None None None None 10.1021/jm9707131
10814746 181592 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 484 6 1 8 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
CHEMBL47706 181592 None 0 Human Binding pIC50 = 7.9 7.9 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 484 6 1 8 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
10122675 98470 None 0 Human Binding pIC50 = 7.9 7.9 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 682 12 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL275897 98470 None 0 Human Binding pIC50 = 7.9 7.9 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 682 12 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL1791271 208914 None 2 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00152-J
9831249 59695 None 0 Human Binding pIC50 = 7.9 7.9 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 672 14 2 10 6.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL172297 59695 None 0 Human Binding pIC50 = 7.9 7.9 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 672 14 2 10 6.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
44311283 102331 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 649 11 2 10 6.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL303649 102331 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 649 11 2 10 6.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44320590 106559 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 556 10 2 9 4.8 COc1ccc(Cn2nc(-c3cccs3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c(OCC(=O)O)c1 10.1016/s0960-894x(00)00513-8
CHEMBL314206 106559 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 556 10 2 9 4.8 COc1ccc(Cn2nc(-c3cccs3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c(OCC(=O)O)c1 10.1016/s0960-894x(00)00513-8
CHEMBL1788127 211114 None 8 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL313760 211114 None 8 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
44382933 165097 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 541 12 4 5 3.2 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCCCC(=O)O 10.1016/0960-894X(95)00144-I
CHEMBL422720 165097 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 541 12 4 5 3.2 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCCCC(=O)O 10.1016/0960-894X(95)00144-I
CHEMBL330144 211325 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C 10.1021/jm00015a003
22616257 205012 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 272 3 1 4 2.4 Cc1noc(NS(=O)(=O)c2ccccc2)c1Cl 10.1016/0960-894X(96)00441-6
CHEMBL76860 205012 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 272 3 1 4 2.4 Cc1noc(NS(=O)(=O)c2ccccc2)c1Cl 10.1016/0960-894X(96)00441-6
44317109 104890 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 472 3 1 4 4.1 Cc1noc(NS(=O)(=O)c2cc(Br)ccc2Br)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL311216 104890 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 472 3 1 4 4.1 Cc1noc(NS(=O)(=O)c2cc(Br)ccc2Br)c1Br 10.1016/0960-894X(96)00441-6
18617327 205254 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1ccccc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL78929 205254 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1ccccc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
44276969 106837 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 506 7 1 5 4.8 COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144607 106837 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 506 7 1 5 4.8 COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
9961131 132155 None 0 Human Binding pIC50 = 6.9 6.9 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 650 15 2 12 3.1 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL369676 132155 None 0 Human Binding pIC50 = 6.9 6.9 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 650 15 2 12 3.1 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL342617 211674 None 0 Pig Binding pIC50 = 6.9 6.9 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL407639 212670 None 0 Pig Binding pIC50 = 6.9 6.9 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CS(=O)(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10381121 96231 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3ccc(N)cc23)c1C 10.1021/jm00008a013
CHEMBL26090 96231 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3ccc(N)cc23)c1C 10.1021/jm00008a013
9974856 99351 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3ccc(N(C)C)cc3c2)c1C 10.1021/jm00008a013
CHEMBL282401 99351 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3ccc(N(C)C)cc3c2)c1C 10.1021/jm00008a013
CHEMBL1790499 208890 None 0 Pig Binding pIC50 = 5.9 5.9 - 0
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL None None None CC[C@@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC1=O 10.1021/jm00089a028
CHEMBL327350 211288 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
18617355 204952 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1ccc(S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/0960-894X(96)00441-6
CHEMBL76438 204952 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1ccc(S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/0960-894X(96)00441-6
CHEMBL432683 213632 None 0 Pig Binding pIC50 = 5.9 5.9 - 0
Compound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscleCompound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscle
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00087a001
10618969 207340 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 367 7 1 5 4.8 O=[N+]([O-])c1ccc(OCc2ccsc2)cc1/C=C(/CO)c1ccccc1 10.1021/jm970847e
CHEMBL93596 207340 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 367 7 1 5 4.8 O=[N+]([O-])c1ccc(OCc2ccsc2)cc1/C=C(/CO)c1ccccc1 10.1021/jm970847e
127034901 136476 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 670 12 2 9 5.5 CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736037 136476 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 670 12 2 9 5.5 CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44298382 195110 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 502 11 1 7 5.8 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCCC=O)c1 10.1016/s0960-894x(00)00366-8
CHEMBL54998 195110 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 502 11 1 7 5.8 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCCC=O)c1 10.1016/s0960-894x(00)00366-8
9974856 99351 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3ccc(N(C)C)cc3c2)c1C 10.1021/jm00004a012
CHEMBL282401 99351 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3ccc(N(C)C)cc3c2)c1C 10.1021/jm00004a012
CHEMBL343379 211697 None 0 Pig Binding pIC50 = 5.9 5.9 - 0
Inhibitory effect against porcine Endothelin A receptorInhibitory effect against porcine Endothelin A receptor
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
CHEMBL343379 211697 None 0 Pig Binding pIC50 = 5.9 5.9 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
CHEMBL315780 211190 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c1csc2ccccc12)[C@@H](C)CC 10.1021/jm00070a001
10334781 96008 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL25970 96008 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1C 10.1016/0960-894X(96)00441-6
18617299 205272 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1C 10.1016/0960-894X(96)00441-6
CHEMBL79054 205272 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1C 10.1016/0960-894X(96)00441-6
127028930 137302 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 570 9 3 7 6.0 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752444 137302 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 570 9 3 7 6.0 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
10769025 60268 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.6 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(C)CC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL174171 60268 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.6 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(C)CC2)nc1C(=O)O 10.1021/jm950592+
44384656 130093 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 5 1 7 4.5 Cc1noc(NS(=O)(=O)c2ccsc2/C=C/c2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
CHEMBL367763 130093 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 5 1 7 4.5 Cc1noc(NS(=O)(=O)c2ccsc2/C=C/c2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
10577111 206895 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 493 7 1 6 4.0 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)COc2ccc(F)cc2)cc1 10.1021/jm9505369
CHEMBL9084 206895 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 493 7 1 6 4.0 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)COc2ccc(F)cc2)cc1 10.1021/jm9505369
10723203 11448 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 678 14 2 7 6.8 CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C 10.1021/jm990171i
CHEMBL1180350 11448 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 678 14 2 7 6.8 CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C 10.1021/jm990171i
CHEMBL123206 11448 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 678 14 2 7 6.8 CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C 10.1021/jm990171i
44291584 101232 None 0 Human Binding pIC50 = 5.8 5.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 501 8 3 9 3.5 COc1cc(OC)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)O)c1 10.1021/jm9608366
CHEMBL296074 101232 None 0 Human Binding pIC50 = 5.8 5.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 501 8 3 9 3.5 COc1cc(OC)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)O)c1 10.1021/jm9608366
10625875 129646 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 523 9 4 5 4.6 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL367313 129646 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 523 9 4 5 4.6 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
10625875 129646 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 523 9 4 5 4.6 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL367313 129646 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 523 9 4 5 4.6 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
22998447 206673 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 414 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2sccc2Oc2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL89457 206673 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 414 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2sccc2Oc2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
10381121 96231 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3ccc(N)cc23)c1C 10.1021/jm00004a012
CHEMBL26090 96231 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3ccc(N)cc23)c1C 10.1021/jm00004a012
10718688 183624 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 457 5 3 7 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cccc(O)c2)c1Br 10.1021/jm9608366
CHEMBL48024 183624 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 457 5 3 7 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cccc(O)c2)c1Br 10.1021/jm9608366
23445325 203385 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 397 5 2 6 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Cl 10.1016/S0960-894X(97)00367-3
CHEMBL65407 203385 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 397 5 2 6 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Cl 10.1016/S0960-894X(97)00367-3
10961546 96757 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
CHEMBL264543 96757 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
122272 97095 None 31 Rat Binding pIC50 = 7.8 7.8 -1 2
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL267458 97095 None 31 Rat Binding pIC50 = 7.8 7.8 -1 2
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00008a013
10961546 96757 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL264543 96757 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
44314751 161353 None 0 Pig Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL412602 161353 None 0 Pig Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
10602620 16589 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 10 2 6 5.4 CCCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL123997 16589 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 10 2 6 5.4 CCCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
10529868 164189 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 516 8 2 6 4.8 CCc1cccc(C)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL421073 164189 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 516 8 2 6 4.8 CCc1cccc(C)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
127035410 136383 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 557 8 1 8 5.7 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C#N)c1)C(=O)CCCC2 10.1039/C4MD00499J
CHEMBL3735155 136383 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 557 8 1 8 5.7 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C#N)c1)C(=O)CCCC2 10.1039/C4MD00499J
44320474 107066 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 440 8 1 5 5.7 CCC(CC)Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
CHEMBL315752 107066 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 440 8 1 5 5.7 CCC(CC)Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
10575845 11227 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 457 7 2 8 3.8 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 10.1021/jm9608366
CHEMBL1178807 11227 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 457 7 2 8 3.8 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 10.1021/jm9608366
CHEMBL43788 11227 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 457 7 2 8 3.8 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 10.1021/jm9608366
10811595 98765 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 411 5 2 6 4.1 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm9608366
10811595 98765 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 411 5 2 6 4.1 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm9700068
CHEMBL278114 98765 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 411 5 2 6 4.1 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm9608366
CHEMBL278114 98765 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 411 5 2 6 4.1 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm9700068
CHEMBL328942 211314 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
CHEMBL150719 208789 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
10360201 95684 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1onc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00004a012
CHEMBL25816 95684 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1onc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00004a012
122272 97095 None 31 Rat Binding pIC50 = 7.8 7.8 -1 2
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00004a012
CHEMBL267458 97095 None 31 Rat Binding pIC50 = 7.8 7.8 -1 2
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00004a012
44283349 100324 None 0 Pig Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCC[C@H](NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL289410 100324 None 0 Pig Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCC[C@H](NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
44334053 4549 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 465 5 1 5 5.5 COc1ccc([C@@H]2c3nc(-c4ccccc4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL102411 4549 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 465 5 1 5 5.5 COc1ccc([C@@H]2c3nc(-c4ccccc4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
10811595 98765 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 411 5 2 6 4.1 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm000349x
CHEMBL278114 98765 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 411 5 2 6 4.1 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm000349x
CHEMBL336563 211582 None 0 Pig Binding pIC50 = 7.8 7.8 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL347948 211712 None 0 Human Binding pIC50 = 7.8 7.8 - 0
The inhibitory constant was evaluated against Endothelin A receptorThe inhibitory constant was evaluated against Endothelin A receptor
ChEMBL None None None CC[C@H](C)[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81219-1
11072080 12102 None 0 Pig Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 600 11 1 9 6.4 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccc3ccccc3n2)c1 10.1021/jm0102304
CHEMBL1183970 12102 None 0 Pig Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 600 11 1 9 6.4 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccc3ccccc3n2)c1 10.1021/jm0102304
CHEMBL326160 12102 None 0 Pig Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 600 11 1 9 6.4 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccc3ccccc3n2)c1 10.1021/jm0102304
155562688 175178 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 554 13 2 10 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
CHEMBL4570529 175178 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 554 13 2 10 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
22616258 105404 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 372 5 1 4 3.8 CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
CHEMBL311781 105404 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 372 5 1 4 3.8 CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
10740943 203404 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 422 5 2 6 3.2 CNc1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 10.1021/jm9604585
CHEMBL6555 203404 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 422 5 2 6 3.2 CNc1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 10.1021/jm9604585
CHEMBL67074 203612 None 0 Pig Binding pIC50 = 7.8 7.8 - 0
Tested for its ability to inhibit the binding of [125I]ET1 to the Endothelin A receptor in porcine thoracic aorta membranes.Tested for its ability to inhibit the binding of [125I]ET1 to the Endothelin A receptor in porcine thoracic aorta membranes.
ChEMBL 646 8 2 13 5.8 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC(=O)C2=C(C)N=C(C)/C(=C(/O)OC)[C@@H]2c2cccc([N+](=O)[O-])c2)[C@@H]1c1cccc([N+](=O)[O-])c1 10.1016/S0960-894X(01)81025-8
122272 97095 None 31 Human Binding pIC50 = 6.8 6.8 1 2
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00029a001
CHEMBL267458 97095 None 31 Human Binding pIC50 = 6.8 6.8 1 2
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00029a001
10095393 97556 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 452 5 3 5 5.3 Cc1noc(NS(=O)(=O)c2cccc3c(N/C(S)=N/c4ccccc4)cccc23)c1C 10.1021/jm00008a013
CHEMBL27063 97556 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 452 5 3 5 5.3 Cc1noc(NS(=O)(=O)c2cccc3c(N/C(S)=N/c4ccccc4)cccc23)c1C 10.1021/jm00008a013
10576863 8286 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 484 5 1 6 5.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)c(Cl)c2)cc1 10.1021/jm9606507
CHEMBL10926 8286 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 484 5 1 6 5.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)c(Cl)c2)cc1 10.1021/jm9606507
44279338 106692 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 487 11 6 4 2.3 CC(C)C[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31436 106692 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 487 11 6 4 2.3 CC(C)C[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44279309 161815 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 412 3 2 3 4.5 Cc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 10.1016/0960-894X(95)00230-Q
CHEMBL414408 161815 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 412 3 2 3 4.5 Cc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 10.1016/0960-894X(95)00230-Q
10641986 207233 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 356 6 1 4 4.2 N#Cc1ccc(OCc2cccnc2)cc1/C=C(/C(=O)O)c1ccccc1 10.1021/jm970847e
CHEMBL92842 207233 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 356 6 1 4 4.2 N#Cc1ccc(OCc2cccnc2)cc1/C=C(/C(=O)O)c1ccccc1 10.1021/jm970847e
44266646 98563 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 475 6 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/s0960-894x(97)10151-2
CHEMBL276638 98563 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 475 6 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/s0960-894x(97)10151-2
10087191 101835 None 1 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3c(N)cccc23)c1C 10.1021/jm00004a012
CHEMBL30039 101835 None 1 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3c(N)cccc23)c1C 10.1021/jm00004a012
CHEMBL424227 213320 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
44334084 109651 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 461 7 2 6 3.8 COc1ccc([C@@H]2c3nc(CCC(=O)O)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL322434 109651 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 461 7 2 6 3.8 COc1ccc([C@@H]2c3nc(CCC(=O)O)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
122272 97095 None 31 Human Binding pIC50 = 6.8 6.8 1 2
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm030480f
CHEMBL267458 97095 None 31 Human Binding pIC50 = 6.8 6.8 1 2
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm030480f
44266646 98563 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 475 6 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1021/jm0300429
CHEMBL276638 98563 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 475 6 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1021/jm0300429
CHEMBL137671 208745 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL335128 211543 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44371429 48898 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 455 6 1 6 5.2 COc1cccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c1 10.1016/s0960-894x(99)00040-2
CHEMBL155973 48898 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 455 6 1 6 5.2 COc1cccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c1 10.1016/s0960-894x(99)00040-2
44316993 204937 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 286 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL76360 204937 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 286 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2)c1C 10.1016/0960-894X(96)00441-6
10983585 173272 None 0 Human Binding pIC50 = 5.8 5.8 - 1
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 473 9 2 8 3.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1021/acs.jmedchem.0c01093
CHEMBL4525321 173272 None 0 Human Binding pIC50 = 5.8 5.8 - 1
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 473 9 2 8 3.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1021/acs.jmedchem.0c01093
10650477 114247 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 10 2 6 5.8 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC(C)C)cc1 10.1021/jm990170q
CHEMBL333009 114247 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 10 2 6 5.8 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC(C)C)cc1 10.1021/jm990170q
44298356 194983 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 503 10 2 8 5.7 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCC/C=N/O)c1 10.1016/s0960-894x(00)00366-8
CHEMBL54703 194983 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 503 10 2 8 5.7 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCC/C=N/O)c1 10.1016/s0960-894x(00)00366-8
10983585 173272 None 0 Human Binding pIC50 = 5.8 5.8 - 1
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 473 9 2 8 3.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4525321 173272 None 0 Human Binding pIC50 = 5.8 5.8 - 1
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 473 9 2 8 3.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1016/j.bmcl.2016.06.014
66875612 175270 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 495 10 2 10 2.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4572634 175270 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 495 10 2 10 2.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.bmcl.2016.06.014
10693981 59548 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 431 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL171702 59548 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 431 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
15340612 106830 None 1 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 406 5 1 5 3.6 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144599 106830 None 1 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 406 5 1 5 3.6 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
10744921 60051 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 536 10 5 4 4.6 CCc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL173666 60051 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 536 10 5 4 4.6 CCc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
44299023 196496 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 457 6 1 6 4.7 CCc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
CHEMBL56343 196496 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 457 6 1 6 4.7 CCc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
44332577 4704 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 341 3 0 4 4.4 O=CC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL103484 4704 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 341 3 0 4 4.4 O=CC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
44266540 4903 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 447 6 1 7 4.8 COc1ccc2c(c1)c(-c1ccc(OC)c(OC)c1)c(C(=O)O)n2-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10457 4903 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 447 6 1 7 4.8 COc1ccc2c(c1)c(-c1ccc(OC)c(OC)c1)c(C(=O)O)n2-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
44266549 162365 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 415 4 1 6 4.5 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL416518 162365 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 415 4 1 6 4.5 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
19432649 204486 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 487 9 2 8 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCO 10.1016/S0960-894X(97)00400-9
CHEMBL72473 204486 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 487 9 2 8 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCO 10.1016/S0960-894X(97)00400-9
CHEMBL342215 211661 None 0 Pig Binding pIC50 = 5.8 5.8 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2cn(C(=O)OC(C)(C)C)c3ccccc23)NC1=O 10.1021/jm00021a021
44279349 168145 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 448 3 2 3 5.3 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3cccc4ccccc34)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL433039 168145 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 448 3 2 3 5.3 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3cccc4ccccc34)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL336087 211575 None 0 Pig Binding pIC50 = 4.8 4.8 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00021a021
44386537 127808 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 532 10 4 7 4.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2cccnc2)nc1C(=O)O 10.1021/jm950592+
CHEMBL366391 127808 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 532 10 4 7 4.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2cccnc2)nc1C(=O)O 10.1021/jm950592+
10188517 61764 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 582 9 2 10 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL177203 61764 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 582 9 2 10 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
10122442 130695 None 0 Human Binding pIC50 = 6.8 6.8 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 660 14 2 11 5.6 CCCCNC(=O)OCC#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL368383 130695 None 0 Human Binding pIC50 = 6.8 6.8 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 660 14 2 11 5.6 CCCCNC(=O)OCC#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10832511 203402 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 362 4 1 5 3.2 CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Cl)cn3)cccc12 10.1021/jm9604585
CHEMBL6553 203402 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 362 4 1 5 3.2 CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Cl)cn3)cccc12 10.1021/jm9604585
104865 705 None 99 Human Binding pIC50 = 5.8 5.8 1 4
Antagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstrictionAntagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstriction
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.8b00435
3494 705 None 99 Human Binding pIC50 = 5.8 5.8 1 4
Antagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstrictionAntagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstriction
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.8b00435
392 705 None 99 Human Binding pIC50 = 5.8 5.8 1 4
Antagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstrictionAntagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstriction
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.8b00435
CHEMBL957 705 None 99 Human Binding pIC50 = 5.8 5.8 1 4
Antagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstrictionAntagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstriction
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.8b00435
DB00559 705 None 99 Human Binding pIC50 = 5.8 5.8 1 4
Antagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstrictionAntagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstriction
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.8b00435
10569313 97201 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 342 4 1 5 2.8 Cc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nn1 10.1021/jm9604585
CHEMBL268387 97201 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 342 4 1 5 2.8 Cc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nn1 10.1021/jm9604585
5018984 203128 None 2 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 405 4 1 4 3.9 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)cn3)cccc12 10.1021/jm9604585
CHEMBL6411 203128 None 2 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 405 4 1 4 3.9 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)cn3)cccc12 10.1021/jm9604585
10690058 203195 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 362 4 1 5 3.2 CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Cl)cn3)cccc12 10.1021/jm9604585
CHEMBL6433 203195 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 362 4 1 5 3.2 CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Cl)cn3)cccc12 10.1021/jm9604585
5017966 203264 None 2 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 341 4 1 4 3.4 Cc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nc1 10.1021/jm9604585
CHEMBL6463 203264 None 2 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 341 4 1 4 3.4 Cc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nc1 10.1021/jm9604585
23445285 112375 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 454 7 1 5 5.6 CCCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
CHEMBL329560 112375 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 454 7 1 5 5.6 CCCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
10250826 99103 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 407 5 1 5 4.7 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1-c1ccccc1 10.1021/jm00008a013
CHEMBL280823 99103 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 407 5 1 5 4.7 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1-c1ccccc1 10.1021/jm00008a013
9980084 102131 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 429 10 1 5 5.7 CCCCN(CCCC)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL30245 102131 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 429 10 1 5 5.7 CCCCN(CCCC)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
9852624 128679 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 656 14 2 11 4.5 CCS(=O)(=O)NCCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL366872 128679 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 656 14 2 11 4.5 CCS(=O)(=O)NCCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
10744040 113567 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cccc(C)c2C)cc1 10.1021/jm031041j
CHEMBL332231 113567 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cccc(C)c2C)cc1 10.1021/jm031041j
10815726 11446 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 516 8 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2C)cc1 10.1021/jm990171i
CHEMBL1180348 11446 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 516 8 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2C)cc1 10.1021/jm990171i
CHEMBL123146 11446 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 516 8 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2C)cc1 10.1021/jm990171i
10671649 98564 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 5 1 8 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL276639 98564 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 5 1 8 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
10299975 110252 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 488 14 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC(C)CC 10.1021/jm980217s
CHEMBL323791 110252 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 488 14 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC(C)CC 10.1021/jm980217s
10816152 16331 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 534 9 2 8 3.9 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(OC)cccc2OC)cc1 10.1021/jm990170q
CHEMBL122832 16331 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 534 9 2 8 3.9 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(OC)cccc2OC)cc1 10.1021/jm990170q
10744040 113567 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cccc(C)c2C)cc1 10.1021/jm990170q
CHEMBL332231 113567 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cccc(C)c2C)cc1 10.1021/jm990170q
10552344 59213 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 471 7 1 6 5.1 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1C(F)(F)F 10.1021/jm990378b
CHEMBL170202 59213 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 471 7 1 6 5.1 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1C(F)(F)F 10.1021/jm990378b
44295156 14625 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 520 10 1 9 4.7 COc1ccccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 10.1016/s0960-894x(98)00301-1
CHEMBL1205062 14625 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 520 10 1 9 4.7 COc1ccccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 10.1016/s0960-894x(98)00301-1
CHEMBL48411 14625 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 520 10 1 9 4.7 COc1ccccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 10.1016/s0960-894x(98)00301-1
10231591 131358 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 569 10 2 11 2.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL368828 131358 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 569 10 2 11 2.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
10338502 119473 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3noc(C)c3C)cccc12 10.1021/jm00004a012
CHEMBL345247 119473 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3noc(C)c3C)cccc12 10.1021/jm00004a012
44386370 60413 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 531 10 4 6 4.8 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2)nc1C(=O)O 10.1021/jm950592+
CHEMBL175066 60413 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 531 10 4 6 4.8 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2)nc1C(=O)O 10.1021/jm950592+
15453177 205519 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL80857 205519 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
10601795 96970 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 10 1 6 4.4 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CC(C)C)CC(C)C)cc1 10.1021/jm9505369
CHEMBL266354 96970 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 10 1 6 4.4 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CC(C)C)CC(C)C)cc1 10.1021/jm9505369
44265869 97260 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 466 7 2 6 3.3 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2CCCC2)cc1 10.1021/jm9505369
CHEMBL268864 97260 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 466 7 2 6 3.3 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2CCCC2)cc1 10.1021/jm9505369
44278003 99266 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 449 8 1 6 5.6 COc1cccc(Sc2c(C(=O)O)n(Cc3ccccc3)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL28188 99266 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 449 8 1 6 5.6 COc1cccc(Sc2c(C(=O)O)n(Cc3ccccc3)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
18617302 104414 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 334 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccccc2F)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL310361 104414 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 334 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccccc2F)c1Br 10.1016/0960-894X(96)00441-6
15453180 105223 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 348 4 1 4 4.1 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Cl 10.1016/0960-894X(96)00441-6
CHEMBL311510 105223 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 348 4 1 4 4.1 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Cl 10.1016/0960-894X(96)00441-6
10951244 202951 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1cc(OC)ccc1OC)O2 10.1021/jm010382z
CHEMBL62962 202951 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1cc(OC)ccc1OC)O2 10.1021/jm010382z
11100307 203199 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 5 1 5 3.8 CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
CHEMBL64340 203199 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 5 1 5 3.8 CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
44314461 204777 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 605 13 5 4 3.9 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCC1)C(=O)O 10.1021/jm9600914
CHEMBL74837 204777 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 605 13 5 4 3.9 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCC1)C(=O)O 10.1021/jm9600914
10767778 16400 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cc(C)cc(C)c2)cc1 10.1021/jm990170q
CHEMBL123077 16400 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cc(C)cc(C)c2)cc1 10.1021/jm990170q
44295114 14878 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 556 11 1 9 5.3 COc1cc(C/C(C(=O)c2ccc(OC(F)F)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL1207717 14878 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 556 11 1 9 5.3 COc1cc(C/C(C(=O)c2ccc(OC(F)F)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL433090 14878 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 556 11 1 9 5.3 COc1cc(C/C(C(=O)c2ccc(OC(F)F)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
122044 10171 None 51 Pig Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 473 9 2 8 3.7 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 10.1021/jm0102304
CHEMBL115951 10171 None 51 Pig Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 473 9 2 8 3.7 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 10.1021/jm0102304
44309814 103004 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 487 8 1 7 6.2 CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1cc2nsnc2cc1C 10.1016/s0960-894x(97)10151-2
CHEMBL306863 103004 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 487 8 1 7 6.2 CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1cc2nsnc2cc1C 10.1016/s0960-894x(97)10151-2
44327380 111602 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 457 6 1 9 1.4 COc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C)ccc2=O)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL328311 111602 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 457 6 1 9 1.4 COc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C)ccc2=O)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL136634 208738 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C(C)C)NC1=O 10.1021/jm00021a021
CHEMBL337031 211588 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL342840 211692 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10926281 102756 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@H](c1ccc3c(c1)OCO3)O2 10.1021/jm031041j
CHEMBL305117 102756 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@H](c1ccc3c(c1)OCO3)O2 10.1021/jm031041j
10926281 102756 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@H](c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL305117 102756 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@H](c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
11026419 203180 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 432 5 1 6 4.5 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3c(OC)cccc32)cc1 10.1021/jm010382z
CHEMBL64266 203180 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 432 5 1 6 4.5 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3c(OC)cccc32)cc1 10.1021/jm010382z
44368819 168890 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1637 31 19 20 1.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
77282140 168890 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1637 31 19 20 1.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL438380 168890 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1637 31 19 20 1.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
44270524 98205 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 682 13 1 9 6.9 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccccc1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL274243 98205 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 682 13 1 9 6.9 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccccc1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
44267002 98557 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 546 5 1 7 5.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc3c2CCc2ccccc2C3=O)cc1 10.1021/jm9606507
CHEMBL276601 98557 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 546 5 1 7 5.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc3c2CCc2ccccc2C3=O)cc1 10.1021/jm9606507
10627398 130685 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 599 11 4 5 5.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)o1 10.1021/jm950591h
CHEMBL368339 130685 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 599 11 4 5 5.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)o1 10.1021/jm950591h
10841170 12117 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 592 9 2 6 5.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 10.1021/jm990171i
CHEMBL1184090 12117 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 592 9 2 6 5.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 10.1021/jm990171i
CHEMBL332109 12117 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 592 9 2 6 5.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 10.1021/jm990171i
10579647 168476 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 612 11 4 5 5.8 Cc1c(C(=O)O)nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)n1Cc1ccccc1 10.1021/jm950592+
CHEMBL435156 168476 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 612 11 4 5 5.8 Cc1c(C(=O)O)nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)n1Cc1ccccc1 10.1021/jm950592+
10575061 206891 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 439 9 1 6 4.0 CCCCC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9082 206891 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 439 9 1 6 4.0 CCCCC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10646637 207046 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 437 8 1 5 4.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C/C=C/CC(C)C)cc1 10.1021/jm9505369
CHEMBL9168 207046 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 437 8 1 5 4.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C/C=C/CC(C)C)cc1 10.1021/jm9505369
44368416 44690 None 0 Pig Binding pIC50 = 4.8 4.8 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 540 8 2 6 5.6 O=C(O)C(Cc1c[nH]c2ccccc12)N(Cc1cc2c(cc1Cl)OCO2)Cc1cc2c(cc1Cl)OCO2 10.1016/s0960-894x(01)00009-9
CHEMBL152098 44690 None 0 Pig Binding pIC50 = 4.8 4.8 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 540 8 2 6 5.6 O=C(O)C(Cc1c[nH]c2ccccc12)N(Cc1cc2c(cc1Cl)OCO2)Cc1cc2c(cc1Cl)OCO2 10.1016/s0960-894x(01)00009-9
10478562 131796 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 442 6 1 6 4.5 Cc1ccc(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00132-7
CHEMBL369359 131796 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 442 6 1 6 4.5 Cc1ccc(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00132-7
127026043 137351 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 607 11 3 9 3.8 CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752947 137351 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 607 11 3 9 3.8 CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
44386162 60407 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 575 11 1 9 6.2 CC/C=C/COc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL175005 60407 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 575 11 1 9 6.2 CC/C=C/COc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10503334 173342 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 441 5 2 6 3.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br 10.1016/S0960-894X(97)00367-3
CHEMBL45269 173342 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 441 5 2 6 3.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br 10.1016/S0960-894X(97)00367-3
10503334 173342 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 441 5 2 6 3.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br 10.1021/jm9608366
CHEMBL45269 173342 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 441 5 2 6 3.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br 10.1021/jm9608366
10140871 59249 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 484 9 2 9 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)ncnc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL170342 59249 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 484 9 2 9 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)ncnc1OCC#CCO 10.1016/s0960-894x(02)01084-3
44383754 59881 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 452 5 1 5 5.4 Cc1ccc(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL172987 59881 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 452 5 1 5 5.4 Cc1ccc(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL319660 211218 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
11005243 203379 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL65337 203379 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
9801093 59234 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 399 7 1 5 5.1 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
CHEMBL170296 59234 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 399 7 1 5 5.1 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
44295089 14630 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 476 8 1 7 5.4 COc1ccc(C(=O)/C(Cc2ccc(SC)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1205088 14630 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 476 8 1 7 5.4 COc1ccc(C(=O)/C(Cc2ccc(SC)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL51030 14630 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 476 8 1 7 5.4 COc1ccc(C(=O)/C(Cc2ccc(SC)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
44320192 107054 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 480 6 1 5 5.9 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1Cc1cccc(Cl)c1 10.1016/s0960-894x(00)00513-8
CHEMBL315622 107054 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 480 6 1 5 5.9 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1Cc1cccc(Cl)c1 10.1016/s0960-894x(00)00513-8
10504542 179561 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 469 6 2 6 4.4 CCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
CHEMBL47418 179561 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 469 6 2 6 4.4 CCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
44386536 130711 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2F)nc1C(=O)O 10.1021/jm950592+
CHEMBL368461 130711 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2F)nc1C(=O)O 10.1021/jm950592+
10626245 131160 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 539 10 2 8 5.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)OC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL368629 131160 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 539 10 2 8 5.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)OC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
44311516 204116 None 0 Human Binding pIC50 = 7.8 7.8 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 678 12 2 12 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70339 204116 None 0 Human Binding pIC50 = 7.8 7.8 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 678 12 2 12 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
137633242 156478 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 569 10 2 10 3.8 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCOC)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4067475 156478 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 569 10 2 10 3.8 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCOC)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
10599230 206993 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 440 8 2 6 2.8 CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9141 206993 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 440 8 2 6 2.8 CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
71458718 81672 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 615 14 1 12 4.3 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C)cn1 10.1021/jm3009103
CHEMBL2163700 81672 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 615 14 1 12 4.3 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C)cn1 10.1021/jm3009103
44320783 106691 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 453 6 1 6 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccnc2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
CHEMBL314357 106691 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 453 6 1 6 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccnc2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
18995986 99579 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 537 8 1 10 5.0 COc1ccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC 10.1016/0960-894X(96)00232-6
CHEMBL283858 99579 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 537 8 1 10 5.0 COc1ccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC 10.1016/0960-894X(96)00232-6
18617379 205222 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 364 3 1 4 3.5 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2C)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL78669 205222 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 364 3 1 4 3.5 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2C)c1Br 10.1016/0960-894X(96)00441-6
10622616 8056 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 5 1 6 4.5 CSc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL10911 8056 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 5 1 6 4.5 CSc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
10412464 9135 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 470 6 1 5 5.4 COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
CHEMBL10996 9135 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 470 6 1 5 5.4 COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
11826883 200149 None 1 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 8 1 6 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)c(OC)c3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL59635 200149 None 1 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 8 1 6 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)c(OC)c3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
11017198 109011 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 563 12 1 8 6.0 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOCc2ccccc2)c1 10.1021/jm0102304
CHEMBL321226 109011 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 563 12 1 8 6.0 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOCc2ccccc2)c1 10.1021/jm0102304
10765567 111352 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 440 9 1 5 3.4 CCCN(C)C(=O)CN1C[C@H](c2cccc(OC)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL326951 111352 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 440 9 1 5 3.4 CCCN(C)C(=O)CN1C[C@H](c2cccc(OC)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
9870117 194884 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 488 10 1 7 5.5 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 10.1016/j.bmcl.2016.06.014
CHEMBL54057 194884 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 488 10 1 7 5.5 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 10.1016/j.bmcl.2016.06.014
9870117 194884 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 488 10 1 7 5.5 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 10.1016/s0960-894x(00)00366-8
CHEMBL54057 194884 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 488 10 1 7 5.5 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 10.1016/s0960-894x(00)00366-8
44277367 106836 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 392 4 2 5 3.3 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144606 106836 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 392 4 2 5 3.3 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(O)c1 10.1016/s0960-894x(00)00232-8
44387128 168587 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 558 12 2 10 3.8 CNCC(=O)OCCOc1nc(C)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/S0960-894X(97)00400-9
CHEMBL435895 168587 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 558 12 2 10 3.8 CNCC(=O)OCCOc1nc(C)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/S0960-894X(97)00400-9
CHEMBL422464 213285 None 0 Pig Binding pIC50 = 5.8 5.8 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
5310990 166828 None 11 Rat Binding pIC50 = 6.8 6.8 - 1
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL428504 166828 None 11 Rat Binding pIC50 = 6.8 6.8 - 1
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
23445506 112556 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 428 5 1 6 4.3 COc1ccccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL330003 112556 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 428 5 1 6 4.3 COc1ccccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
10452145 98202 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 376 5 1 7 2.9 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1[N+](=O)[O-] 10.1021/jm00008a013
CHEMBL27420 98202 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 376 5 1 7 2.9 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1[N+](=O)[O-] 10.1021/jm00008a013
10813007 113318 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 440 9 1 5 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL331577 113318 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 440 9 1 5 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
44384852 60238 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 544 9 1 8 5.5 C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL174094 60238 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 544 9 1 8 5.5 C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10362674 97780 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 385 4 1 5 4.2 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCCC4)cccc23)c1C 10.1021/jm00008a013
CHEMBL27178 97780 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 385 4 1 5 4.2 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCCC4)cccc23)c1C 10.1021/jm00008a013
10742446 207010 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 456 9 2 7 2.0 COCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9147 207010 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 456 9 2 7 2.0 COCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10650638 9182 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 566 13 1 6 4.8 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 10.1021/jm970101g
CHEMBL110305 9182 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 566 13 1 6 4.8 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 10.1021/jm970101g
10647898 97344 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 466 5 1 6 5.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc3ccccc23)cc1 10.1021/jm9606507
CHEMBL269409 97344 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 466 5 1 6 5.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc3ccccc23)cc1 10.1021/jm9606507
10993781 201347 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 434 7 1 7 5.0 CCCCC1=C(c2nnn[nH]2)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL60440 201347 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 434 7 1 7 5.0 CCCCC1=C(c2nnn[nH]2)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10896412 202802 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1OC)O2 10.1021/jm010382z
CHEMBL62277 202802 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1OC)O2 10.1021/jm010382z
15410997 4706 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 563 8 1 7 6.3 COc1ccc(C2(OC(=O)N[C@@H](C)c3ccccc3)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL103501 4706 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 563 8 1 7 6.3 COc1ccc(C2(OC(=O)N[C@@H](C)c3ccccc3)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL2370534 209867 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@H](CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](N)Cc2ccccc2)C(C)C)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC 10.1021/jm990170q
151174 202718 None 45 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 605 12 3 13 3.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL61780 202718 None 45 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 605 12 3 13 3.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO 10.1016/j.bmcl.2016.06.014
76319370 85354 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 564 8 1 9 4.0 CCOC(=O)c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C)cc3OC)c3ccc4c(c3)OCO4)cn(C)c2c1 10.1007/s00044-004-0021-y
CHEMBL2261602 85354 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 564 8 1 9 4.0 CCOC(=O)c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C)cc3OC)c3ccc4c(c3)OCO4)cn(C)c2c1 10.1007/s00044-004-0021-y
10050696 96776 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 476 7 1 6 5.3 COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00513-8
CHEMBL26474 96776 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 476 7 1 6 5.3 COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00513-8
10050696 96776 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 476 7 1 6 5.3 COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL26474 96776 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 476 7 1 6 5.3 COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00232-8
10138169 99359 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 440 6 1 8 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
CHEMBL282470 99359 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 440 6 1 8 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
10211772 56521 None 0 Human Binding pIC50 = 7.8 7.8 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 660 11 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL163638 56521 None 0 Human Binding pIC50 = 7.8 7.8 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 660 11 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
10165809 131797 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 541 9 2 11 2.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL369362 131797 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 541 9 2 11 2.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL61900 215839 None 0 Pig Binding pIC50 = 7.8 7.8 - 0
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
44327412 207579 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 5 1 8 3.0 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL94929 207579 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 5 1 8 3.0 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
44385621 128194 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.6 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2C)nc1C(=O)O 10.1021/jm950592+
CHEMBL366544 128194 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.6 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2C)nc1C(=O)O 10.1021/jm950592+
44356917 119239 None 0 Pig Binding pIC50 = 7.8 7.8 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 638 8 5 8 0.3 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2cn(C=O)c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL343516 119239 None 0 Pig Binding pIC50 = 7.8 7.8 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 638 8 5 8 0.3 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2cn(C=O)c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL2370825 209926 None 0 Pig Binding pIC50 = 7.8 7.8 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2C[C@@H](O)CN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
11091217 101065 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 9 1 6 5.0 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2cc(OCCC)ccc21 10.1021/jm010382z
CHEMBL294787 101065 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 9 1 6 5.0 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2cc(OCCC)ccc21 10.1021/jm010382z
44314722 155749 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 597 14 5 4 4.9 CCCCC(NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL405724 155749 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 597 14 5 4 4.9 CCCCC(NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL293216 210887 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
44283421 100155 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 597 14 5 4 4.9 CCCC[C@H](NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL287888 100155 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 597 14 5 4 4.9 CCCC[C@H](NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
44383742 168503 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 452 5 1 5 5.4 Cc1ccc(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL435346 168503 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 452 5 1 5 5.4 Cc1ccc(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL137361 208742 None 0 Pig Binding pIC50 = 6.8 6.8 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL313382 211111 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL86814 215890 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
44368819 168890 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1637 31 19 20 1.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
77282140 168890 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1637 31 19 20 1.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL438380 168890 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1637 31 19 20 1.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
44316973 205603 None 2 Human Binding pIC50 = 5.8 5.8 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2cccc(Br)c2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL81593 205603 None 2 Human Binding pIC50 = 5.8 5.8 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2cccc(Br)c2)c1C 10.1016/0960-894X(96)00441-6
127035067 136390 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 683 12 2 9 5.4 CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735236 136390 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 683 12 2 9 5.4 CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44368824 96825 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1595 31 19 20 0.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
77282142 96825 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1595 31 19 20 0.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL265164 96825 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1595 31 19 20 0.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL436899 213692 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
44277034 106841 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 406 5 1 5 3.6 COc1ccccc1Cn1[nH]c(C(F)(F)F)c(Cc2ccc3c(c2)OCO3)c1=O 10.1016/s0960-894x(00)00232-8
CHEMBL3144729 106841 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 406 5 1 5 3.6 COc1ccccc1Cn1[nH]c(C(F)(F)F)c(Cc2ccc3c(c2)OCO3)c1=O 10.1016/s0960-894x(00)00232-8
CHEMBL1791279 208917 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)[C@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00152-J
CHEMBL5272983 193741 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 439 7 2 6 3.3 O=S(=O)(Nc1ncnc(OCCO)c1-c1ccccc1)c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.0c01093
19735343 176049 None 0 Human Binding pIC50 = 4.8 4.8 - 1
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 473 7 2 6 4.0 O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4590568 176049 None 0 Human Binding pIC50 = 4.8 4.8 - 1
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 473 7 2 6 4.0 O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2016.06.014
23445516 106626 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 468 7 1 5 5.9 Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(CCC(C)C)cc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL314307 106626 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 468 7 1 5 5.9 Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(CCC(C)C)cc2)c1Br 10.1016/S0960-894X(96)00496-9
23445354 206633 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 426 5 1 5 4.8 CCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
CHEMBL89203 206633 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 426 5 1 5 4.8 CCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
CHEMBL273391 210807 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL273391 210807 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
18184206 60330 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 600 13 2 11 3.2 CCS(=O)(=O)NCCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL174413 60330 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 600 13 2 11 3.2 CCS(=O)(=O)NCCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
44385792 60349 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 617 13 2 11 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL174547 60349 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 617 13 2 11 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
44384966 59995 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 545 9 1 9 4.8 C#CCOc1nc(-c2cnccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL173465 59995 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 545 9 1 9 4.8 C#CCOc1nc(-c2cnccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
71460537 81695 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 660 12 1 13 2.7 COc1ccccc1Oc1c(NS(=O)(=O)N2CCOCC2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163722 81695 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 660 12 1 13 2.7 COc1ccccc1Oc1c(NS(=O)(=O)N2CCOCC2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
10765057 163158 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 4 1 7 3.5 O=C1OC(O)(c2ccc3c(c2)OCO3)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL417978 163158 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 4 1 7 3.5 O=C1OC(O)(c2ccc3c(c2)OCO3)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL2304012 209466 None 0 Pig Binding pIC50 = 7.7 7.7 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)[C@H]1NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC1=O 10.1021/jm9600914
44458399 98990 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 520 7 2 7 4.2 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CO)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL279947 98990 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 520 7 2 7 4.2 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CO)ccc23)cc1 10.1016/s0960-894x(01)00660-6
73669992 117629 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 387 9 1 4 5.4 N#CCCC(Oc1cc(OCc2ccccc2)ccc1C(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
CHEMBL3400998 117629 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 387 9 1 4 5.4 N#CCCC(Oc1cc(OCc2ccccc2)ccc1C(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
10814776 99471 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 5 2 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm9608366
10814776 99471 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 5 2 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
CHEMBL283136 99471 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 5 2 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm9608366
CHEMBL283136 99471 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 5 2 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
44387111 166180 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 548 10 5 5 4.2 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
CHEMBL426413 166180 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 548 10 5 5 4.2 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
9830773 130224 None 0 Human Binding pIC50 = 7.7 7.7 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 636 14 2 12 2.8 CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL367958 130224 None 0 Human Binding pIC50 = 7.7 7.7 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 636 14 2 12 2.8 CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
10814776 99471 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 485 5 2 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm000349x
CHEMBL283136 99471 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 485 5 2 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm000349x
CHEMBL341994 211659 None 0 Pig Binding pIC50 = 7.7 7.7 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C2=CCC=CC2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10410546 9410 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
CHEMBL11162 9410 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
44279481 112381 None 0 Pig Binding pIC50 = 6.7 6.7 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 555 11 5 4 4.0 CC(C)C[C@H](NC(=O)N1C(C)(C)CCCC1(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL32959 112381 None 0 Pig Binding pIC50 = 6.7 6.7 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 555 11 5 4 4.0 CC(C)C[C@H](NC(=O)N1C(C)(C)CCCC1(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
10674095 113511 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 9 1 6 5.1 CCc1cccc(CC)c1N(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL332093 113511 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 9 1 6 5.1 CCc1cccc(CC)c1N(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL135906 208732 None 0 Pig Binding pIC50 = 6.7 6.7 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44316983 104794 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 312 5 1 6 2.1 COc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1OC 10.1016/0960-894X(96)00441-6
CHEMBL310944 104794 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 312 5 1 6 2.1 COc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1OC 10.1016/0960-894X(96)00441-6
44371670 141661 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptorBinding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor
ChEMBL 1082 23 11 10 3.7 CC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C1c2ccccc2CCc2ccccc21 10.1016/0960-894X(95)00084-7
CHEMBL385405 141661 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptorBinding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor
ChEMBL 1082 23 11 10 3.7 CC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C1c2ccccc2CCc2ccccc21 10.1016/0960-894X(95)00084-7
44277035 106850 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 410 4 1 4 4.2 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(Cl)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144806 106850 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 410 4 1 4 4.2 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(Cl)c1 10.1016/s0960-894x(00)00232-8
10554385 60213 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 537 10 4 5 4.8 CCc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL174000 60213 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 537 10 4 5 4.8 CCc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
10721963 60557 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 580 11 5 6 3.7 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)NCC(=O)O 10.1021/jm950592+
CHEMBL175924 60557 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 580 11 5 6 3.7 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)NCC(=O)O 10.1021/jm950592+
44386620 170603 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccc(F)cc2)nc1C(=O)O 10.1021/jm950592+
CHEMBL445076 170603 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccc(F)cc2)nc1C(=O)O 10.1021/jm950592+
44311218 103125 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 607 11 2 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1ccncc1 10.1016/S0960-894X(97)00400-9
CHEMBL307803 103125 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 607 11 2 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1ccncc1 10.1016/S0960-894X(97)00400-9
18617344 205276 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 361 4 1 6 2.5 Cc1noc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL79080 205276 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 361 4 1 6 2.5 Cc1noc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1Br 10.1016/0960-894X(96)00441-6
15342056 207011 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 322 3 1 5 2.6 Cc1noc(NS(=O)(=O)c2cccs2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL91470 207011 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 322 3 1 5 2.6 Cc1noc(NS(=O)(=O)c2cccs2)c1Br 10.1016/S0960-894X(96)00496-9
10503976 11236 None 0 Human Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 1 6 3.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)N(C)c2ccccc2)c1Br 10.1021/jm9608366
CHEMBL1178874 11236 None 0 Human Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 1 6 3.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)N(C)c2ccccc2)c1Br 10.1021/jm9608366
CHEMBL47536 11236 None 0 Human Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 1 6 3.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)N(C)c2ccccc2)c1Br 10.1021/jm9608366
10211543 131383 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 640 13 2 12 3.5 CCCCNC(=O)OCC#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL368989 131383 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 640 13 2 12 3.5 CCCCNC(=O)OCC#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10341117 163195 None 1 Rat Binding pIC50 = 5.7 5.7 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 403 8 3 6 3.5 Cc1noc(NS(=O)(=O)c2cccc3c(NCCCC(=O)O)cccc23)c1C 10.1021/jm00008a013
CHEMBL418202 163195 None 1 Rat Binding pIC50 = 5.7 5.7 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 403 8 3 6 3.5 Cc1noc(NS(=O)(=O)c2cccc3c(NCCCC(=O)O)cccc23)c1C 10.1021/jm00008a013
10554085 101285 None 0 Human Binding pIC50 = 4.7 4.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 524 6 1 9 3.2 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)N2CCN(Cc3ccc4c(c3)OCO4)CC2)c1Cl 10.1021/jm9700068
CHEMBL296427 101285 None 0 Human Binding pIC50 = 4.7 4.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 524 6 1 9 3.2 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)N2CCN(Cc3ccc4c(c3)OCO4)CC2)c1Cl 10.1021/jm9700068
10817024 12126 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 578 10 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(c2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL1184112 12126 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 578 10 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(c2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL332808 12126 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 578 10 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(c2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
44279140 110630 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 588 12 2 6 5.8 CCCCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL32574 110630 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 588 12 2 6 5.8 CCCCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
11793037 203705 None 3 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 362 4 1 5 3.2 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)nn3)cccc12 10.1021/jm9604585
CHEMBL6761 203705 None 3 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 362 4 1 5 3.2 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)nn3)cccc12 10.1021/jm9604585
9885296 96967 None 1 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 361 4 1 4 3.8 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)cn3)cccc12 10.1021/jm9604585
CHEMBL266315 96967 None 1 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 361 4 1 4 3.8 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)cn3)cccc12 10.1021/jm9604585
10786783 203433 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 393 4 1 5 3.2 COc1nc(Br)cnc1NS(=O)(=O)c1cccc2ccccc12 10.1021/jm9604585
CHEMBL6576 203433 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 393 4 1 5 3.2 COc1nc(Br)cnc1NS(=O)(=O)c1cccc2ccccc12 10.1021/jm9604585
10740137 203511 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)cn3)cccc12 10.1021/jm9604585
CHEMBL6630 203511 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)cn3)cccc12 10.1021/jm9604585
10230836 8907 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 13 1 7 4.1 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
CHEMBL109765 8907 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 13 1 7 4.1 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
10209319 9368 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 13 1 7 4.1 CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC 10.1021/jm970101g
CHEMBL111355 9368 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 13 1 7 4.1 CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC 10.1021/jm970101g
10507211 110369 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 566 13 1 7 3.9 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCCCl 10.1021/jm970101g
CHEMBL324214 110369 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 566 13 1 7 3.9 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCCCl 10.1021/jm970101g
9807691 100062 None 0 Human Binding pIC50 = 8.7 8.7 - 1
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 553 10 1 10 5.3 COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
CHEMBL287169 100062 None 0 Human Binding pIC50 = 8.7 8.7 - 1
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 553 10 1 10 5.3 COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
11732669 203115 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 9 1 6 5.0 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCCC)cc21 10.1021/jm010382z
CHEMBL64039 203115 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 9 1 6 5.0 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCCC)cc21 10.1021/jm010382z
10602267 8585 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 529 13 1 6 3.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCCC1=O 10.1021/jm980217s
CHEMBL109478 8585 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 529 13 1 6 3.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCCC1=O 10.1021/jm980217s
44332842 109719 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 703 11 1 10 7.5 COc1ccc(C2(OC(=O)N[C@@H](C)c3cccc4ccccc34)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL322920 109719 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 703 11 1 10 7.5 COc1ccc(C2(OC(=O)N[C@@H](C)c3cccc4ccccc34)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/S0960-894X(97)00002-4
44315009 103204 None 0 Pig Binding pIC50 = 8.7 8.7 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 665 13 5 5 4.7 CSCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL308403 103204 None 0 Pig Binding pIC50 = 8.7 8.7 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 665 13 5 5 4.7 CSCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
10791702 195814 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2cccc3occc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL558148 195814 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2cccc3occc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
9895957 10671 None 18 Human Binding pIC50 = 8.7 8.7 3 3
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1039/C4MD00499J
CHEMBL11706 10671 None 18 Human Binding pIC50 = 8.7 8.7 3 3
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1039/C4MD00499J
21041288 173924 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 526 10 2 9 2.8 CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4540866 173924 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 526 10 2 9 2.8 CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
155563100 175274 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 619 13 2 10 4.6 COc1cnc(OCCOc2nc(-c3ccncc3)nc(NS(=O)(=O)NCc3ccccc3)c2-c2ccc(Cl)cc2)nc1 10.1016/j.bmcl.2016.06.014
CHEMBL4572734 175274 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 619 13 2 10 4.6 COc1cnc(OCCOc2nc(-c3ccncc3)nc(NS(=O)(=O)NCc3ccccc3)c2-c2ccc(Cl)cc2)nc1 10.1016/j.bmcl.2016.06.014
9829478 175323 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 567 10 1 8 4.9 Cc1ccc(-c2c(NS(=O)(=O)/C=C/c3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4573806 175323 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 567 10 1 8 4.9 Cc1ccc(-c2c(NS(=O)(=O)/C=C/c3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1016/j.bmcl.2016.06.014
10146377 60412 None 0 Human Binding pIC50 = 8.7 8.7 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 662 11 2 14 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL175058 60412 None 0 Human Binding pIC50 = 8.7 8.7 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 662 11 2 14 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
10816682 102139 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 559 10 1 9 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN3CCOCC3)c2)cc1 10.1021/jm980504w
CHEMBL302493 102139 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 559 10 1 9 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN3CCOCC3)c2)cc1 10.1021/jm980504w
10579885 102705 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 632 12 1 11 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN3CCN(C)CC3)c2)cc1 10.1021/jm980504w
CHEMBL304802 102705 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 632 12 1 11 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN3CCN(C)CC3)c2)cc1 10.1021/jm980504w
10814440 98145 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)ccc2OC)cc1 10.1021/jm9606507
CHEMBL273723 98145 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)ccc2OC)cc1 10.1021/jm9606507
71462247 81696 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 680 14 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2cnccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163723 81696 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 680 14 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2cnccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
23548253 81674 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 679 14 1 12 4.7 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1016/j.bmcl.2016.06.014
CHEMBL2163702 81674 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 679 14 1 12 4.7 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1016/j.bmcl.2016.06.014
11014820 202910 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 398 6 1 6 4.2 CCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL62780 202910 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 398 6 1 6 4.2 CCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10602183 9237 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 525 13 1 7 3.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1ccccc1=O 10.1021/jm980217s
CHEMBL110695 9237 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 525 13 1 7 3.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1ccccc1=O 10.1021/jm980217s
10625152 110457 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 498 13 1 6 4.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccoc1 10.1021/jm980217s
CHEMBL324685 110457 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 498 13 1 6 4.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccoc1 10.1021/jm980217s
90766557 170526 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 528 10 2 8 3.1 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4449731 170526 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 528 10 2 8 3.1 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
76312118 85345 None 0 Human Binding pIC50 = 8.7 8.7 691 2
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261361 85345 None 0 Human Binding pIC50 = 8.7 8.7 691 2
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
9916121 81665 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 571 10 1 8 4.1 CCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
CHEMBL2163693 81665 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 571 10 1 8 4.1 CCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
23548253 81674 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 679 14 1 12 4.7 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163702 81674 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 679 14 1 12 4.7 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
44334130 4507 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 458 5 1 6 4.4 COc1ccc([C@@H]2c3nc(N4CCCC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL102173 4507 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 458 5 1 6 4.4 COc1ccc([C@@H]2c3nc(N4CCCC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
9808602 109207 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 590 15 1 8 4.5 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 10.1021/jm970101g
CHEMBL321673 109207 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 590 15 1 8 4.5 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 10.1021/jm970101g
11826062 202987 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 8 2 6 4.3 CC(C)Oc1ccc2c(c1)C(CCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL63113 202987 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 8 2 6 4.3 CC(C)Oc1ccc2c(c1)C(CCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10696876 110334 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 504 13 1 7 3.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OCCO1 10.1021/jm980217s
CHEMBL323989 110334 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 504 13 1 7 3.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OCCO1 10.1021/jm980217s
22467235 96523 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 533 7 2 7 3.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL262784 96523 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 533 7 2 7 3.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
22467235 96523 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 533 7 2 7 3.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1007/s00044-004-0021-y
CHEMBL262784 96523 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 533 7 2 7 3.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1007/s00044-004-0021-y
71462321 82005 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 584 12 2 8 4.2 CCc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
CHEMBL2165335 82005 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 584 12 2 8 4.2 CCc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
9890440 8252 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 10.1021/jm9606507
CHEMBL10924 8252 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 10.1021/jm9606507
10577306 109686 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 499 13 1 7 3.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ncco1 10.1021/jm980217s
CHEMBL322732 109686 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 499 13 1 7 3.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ncco1 10.1021/jm980217s
44315007 204546 None 0 Pig Binding pIC50 = 8.6 8.6 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 679 14 5 5 5.1 CCCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL72891 204546 None 0 Pig Binding pIC50 = 8.6 8.6 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 679 14 5 5 5.1 CCCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
21041273 173746 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 538 12 2 9 2.8 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4536769 173746 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 538 12 2 9 2.8 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
9821701 4610 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 389 4 1 5 3.8 COc1ccc([C@@H]2c3ncccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL102825 4610 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 389 4 1 5 3.8 COc1ccc([C@@H]2c3ncccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
10698065 12111 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 558 11 2 6 5.6 CCC(CC)C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
CHEMBL1184065 12111 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 558 11 2 6 5.6 CCC(CC)C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
CHEMBL330895 12111 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 558 11 2 6 5.6 CCC(CC)C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
CHEMBL171198 208844 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL None None None CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)O 10.1016/0960-894X(95)00144-I
10529742 8190 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 511 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1cccn1C 10.1021/jm980217s
CHEMBL109206 8190 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 511 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1cccn1C 10.1021/jm980217s
10116355 8264 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 474 14 1 5 4.9 CCCCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL109248 8264 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 474 14 1 5 4.9 CCCCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
10648715 109667 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 488 14 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCC(C)C 10.1021/jm980217s
CHEMBL322547 109667 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 488 14 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCC(C)C 10.1021/jm980217s
44320291 105936 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 548 7 2 8 4.8 O=C(O)c1cc2c(c(Cn3nc(-c4ccccc4)c(Cc4cc5c(cc4Cl)OCO5)c3C(=O)O)c1)OCOC2 10.1016/s0960-894x(00)00513-8
CHEMBL312854 105936 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 548 7 2 8 4.8 O=C(O)c1cc2c(c(Cn3nc(-c4ccccc4)c(Cc4cc5c(cc4Cl)OCO5)c3C(=O)O)c1)OCOC2 10.1016/s0960-894x(00)00513-8
17885912 107097 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 496 7 2 6 5.1 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCCC(C(=O)O)C1 10.1016/s0960-894x(00)00513-8
CHEMBL315936 107097 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 496 7 2 6 5.1 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCCC(C(=O)O)C1 10.1016/s0960-894x(00)00513-8
44279295 106000 None 0 Human Binding pIC50 = 8.6 8.6 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 482 8 1 6 4.2 COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(=O)N(C)C)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL31324 106000 None 0 Human Binding pIC50 = 8.6 8.6 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 482 8 1 6 4.2 COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(=O)N(C)C)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
10670600 96574 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 436 6 2 6 3.6 CCNc1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 10.1021/jm9604585
CHEMBL263079 96574 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 436 6 2 6 3.6 CCNc1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 10.1021/jm9604585
10646831 183918 None 0 Human Binding pIC50 = 8.6 8.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 441 6 2 7 4.1 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm9608366
10646831 183918 None 0 Human Binding pIC50 = 8.6 8.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 441 6 2 7 4.1 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm9700068
CHEMBL48134 183918 None 0 Human Binding pIC50 = 8.6 8.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 441 6 2 7 4.1 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm9608366
CHEMBL48134 183918 None 0 Human Binding pIC50 = 8.6 8.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 441 6 2 7 4.1 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm9700068
11751754 102359 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 469 6 3 7 4.1 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)O)c1 10.1021/jm030528p
CHEMBL303806 102359 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 469 6 3 7 4.1 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)O)c1 10.1021/jm030528p
10555516 9239 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 598 12 1 7 4.6 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)Cc1ccccc1 10.1021/jm970101g
CHEMBL110700 9239 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 598 12 1 7 4.6 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)Cc1ccccc1 10.1021/jm970101g
11799503 9751 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 498 13 1 6 4.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccco1 10.1021/jm980217s
CHEMBL113472 9751 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 498 13 1 6 4.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccco1 10.1021/jm980217s
10289311 110433 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 514 13 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)C=C(C)C 10.1021/jm980217s
CHEMBL324586 110433 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 514 13 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)C=C(C)C 10.1021/jm980217s
CHEMBL2304007 209461 None 0 Pig Binding pIC50 = 8.6 8.6 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O 10.1021/jm9600914
44380954 57675 None 0 Pig Binding pIC50 = 8.6 8.6 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 643 11 1 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
CHEMBL166875 57675 None 0 Pig Binding pIC50 = 8.6 8.6 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 643 11 1 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
10525281 182848 None 0 Human Binding pIC50 = 8.6 8.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 404 6 1 6 4.2 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1021/jm9700068
CHEMBL47915 182848 None 0 Human Binding pIC50 = 8.6 8.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 404 6 1 6 4.2 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1021/jm9700068
9888574 104174 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 422 4 1 4 3.9 CCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL309692 104174 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 422 4 1 4 3.9 CCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
11102844 203239 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 7 2 7 4.2 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)CO)cc32)cc1 10.1021/jm010382z
CHEMBL64536 203239 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 7 2 7 4.2 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)CO)cc32)cc1 10.1021/jm010382z
44314906 103576 None 0 Pig Binding pIC50 = 8.6 8.6 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 607 12 6 5 3.4 Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)NC(Cc1c[nH]cn1)C(=O)O 10.1021/jm9600914
CHEMBL308621 103576 None 0 Pig Binding pIC50 = 8.6 8.6 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 607 12 6 5 3.4 Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)NC(Cc1c[nH]cn1)C(=O)O 10.1021/jm9600914
44458670 99050 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 521 7 2 8 2.7 COc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL280379 99050 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 521 7 2 8 2.7 COc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
71455060 81661 None 1 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 614 9 1 9 2.9 O=S(=O)(Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1)N1CCOCC1 10.1021/jm3009103
CHEMBL2163689 81661 None 1 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 614 9 1 9 2.9 O=S(=O)(Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1)N1CCOCC1 10.1021/jm3009103
71451526 81673 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 635 14 1 12 4.6 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Cl)cn1 10.1021/jm3009103
CHEMBL2163701 81673 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 635 14 1 12 4.6 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Cl)cn1 10.1021/jm3009103
10875868 114959 None 0 Pig Binding pIC50 = 8.6 8.6 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 619 9 1 8 5.0 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(Br)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL334263 114959 None 0 Pig Binding pIC50 = 8.6 8.6 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 619 9 1 8 5.0 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(Br)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
9810190 103064 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 563 11 1 10 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCN(C)C)c2)cc1 10.1021/jm980504w
CHEMBL307330 103064 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 563 11 1 10 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCN(C)C)c2)cc1 10.1021/jm980504w
CHEMBL2304015 209469 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL None None None Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O 10.1021/jm9600914
10875239 9585 None 0 Pig Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 541 10 1 10 4.8 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccco2)nc1 10.1021/jm0102304
CHEMBL112502 9585 None 0 Pig Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 541 10 1 10 4.8 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccco2)nc1 10.1021/jm0102304
10791823 9447 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 510 12 1 6 4.7 CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)C(=O)CCC 10.1021/jm970101g
CHEMBL111783 9447 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 510 12 1 6 4.7 CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)C(=O)CCC 10.1021/jm970101g
15289330 99800 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 493 8 1 8 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL285368 99800 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 493 8 1 8 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
10361107 162046 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 2 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(NC(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL416026 162046 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 2 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(NC(C)C)cccc23)c1C 10.1021/jm00008a013
44314658 205166 None 0 Pig Binding pIC50 = 7.7 7.7 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 589 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CCC)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL78230 205166 None 0 Pig Binding pIC50 = 7.7 7.7 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 589 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CCC)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
9951753 166335 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 379 7 1 5 4.7 Cc1ccccc1C(Oc1cc(OCc2ccsc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL427294 166335 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 379 7 1 5 4.7 Cc1ccccc1C(Oc1cc(OCc2ccsc2)ccc1C#N)C(=O)O 10.1021/jm990378b
11797717 207059 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 448 10 2 5 6.0 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1cc[nH]n1 10.1021/jm9707131
CHEMBL91753 207059 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 448 10 2 5 6.0 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1cc[nH]n1 10.1021/jm9707131
10668808 207159 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 402 9 1 5 4.8 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccncc2)ccc1C#N 10.1021/jm9707131
CHEMBL92353 207159 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 402 9 1 5 4.8 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccncc2)ccc1C#N 10.1021/jm9707131
10694804 207818 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 449 10 1 6 6.3 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1ncco1 10.1021/jm9707131
CHEMBL96301 207818 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 449 10 1 6 6.3 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1ncco1 10.1021/jm9707131
10695071 101156 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 6 4.3 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9700068
CHEMBL295477 101156 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 6 4.3 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9700068
10672494 179551 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 483 6 2 6 5.0 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(C(C)C)cc2)c1Br 10.1021/jm9608366
CHEMBL47417 179551 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 483 6 2 6 5.0 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(C(C)C)cc2)c1Br 10.1021/jm9608366
44327412 207579 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 5 1 8 3.0 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL94929 207579 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 5 1 8 3.0 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL343062 211694 None 0 Pig Binding pIC50 = 7.7 7.7 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
443289 710 None 47 Human Binding pIC50 = 7.7 7.7 2 3
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL None None None None 10.1021/jm3009103
997 710 None 47 Human Binding pIC50 = 7.7 7.7 2 3
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL None None None None 10.1021/jm3009103
CHEMBL314691 710 None 47 Human Binding pIC50 = 7.7 7.7 2 3
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL None None None None 10.1021/jm3009103
DB12054 710 None 47 Human Binding pIC50 = 7.7 7.7 2 3
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL None None None None 10.1021/jm3009103
44320431 106954 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 526 9 2 7 4.9 O=C(O)COC1CCCCC1Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
CHEMBL314973 106954 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 526 9 2 7 4.9 O=C(O)COC1CCCCC1Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
10767442 131221 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 492 8 1 5 6.1 COc1ccc(C(=O)/C(Cc2ccc(-c3ccccc3)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL368668 131221 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 492 8 1 5 6.1 COc1ccc(C(=O)/C(Cc2ccc(-c3ccccc3)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL313984 211121 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL265116 210633 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
10815005 9746 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 492 6 1 6 5.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(-c3ccccc3)cc2)cc1 10.1021/jm9606507
CHEMBL11345 9746 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 492 6 1 6 5.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(-c3ccccc3)cc2)cc1 10.1021/jm9606507
10506430 113788 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 532 9 2 7 4.5 CCc1cccc(OC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL332387 113788 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 532 9 2 7 4.5 CCc1cccc(OC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
10669001 112620 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 405 6 1 6 4.6 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm970847e
CHEMBL330255 112620 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 405 6 1 6 4.6 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm970847e
10692108 168168 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 395 6 1 4 5.5 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccccc1Cl 10.1021/jm970847e
CHEMBL433201 168168 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 395 6 1 4 5.5 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccccc1Cl 10.1021/jm970847e
CHEMBL313984 211121 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
10577255 175417 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 497 8 2 6 5.2 CCCCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
CHEMBL45760 175417 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 497 8 2 6 5.2 CCCCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
CHEMBL1793926 208928 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
10769045 131215 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2(C)CCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL368641 131215 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2(C)CCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL134562 208728 None 0 Pig Binding pIC50 = 6.7 6.7 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL436899 213692 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL407933 212692 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)NC1CCCCC1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
18617284 205206 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 350 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL78552 205206 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 350 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1Br 10.1016/0960-894X(96)00441-6
44314579 102915 None 0 Pig Binding pIC50 = 5.7 5.7 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
CHEMBL306123 102915 None 0 Pig Binding pIC50 = 5.7 5.7 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
10549516 110388 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 410 8 1 4 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccccc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL324301 110388 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 410 8 1 4 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccccc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
22010208 207093 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 362 9 1 3 5.3 O=C(O)CCC(Oc1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
CHEMBL91965 207093 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 362 9 1 3 5.3 O=C(O)CCC(Oc1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
10717670 207193 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 433 7 1 5 5.7 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1c(F)cccc1Cl 10.1021/jm970847e
CHEMBL92570 207193 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 433 7 1 5 5.7 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1c(F)cccc1Cl 10.1021/jm970847e
19735404 175819 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 471 9 2 7 3.5 COc1ccccc1Cc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4584753 175819 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 471 9 2 7 3.5 COc1ccccc1Cc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1016/j.bmcl.2016.06.014
10528383 11233 None 0 Human Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 470 5 1 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)c2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
CHEMBL1178854 11233 None 0 Human Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 470 5 1 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)c2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
CHEMBL46357 11233 None 0 Human Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 470 5 1 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)c2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
10604797 102342 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 704 14 1 13 3.3 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OCCN3CCOCC3)c(OC)c(OCCN3CCOCC3)c2)cc1 10.1021/jm980504w
CHEMBL303712 102342 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 704 14 1 13 3.3 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OCCN3CCOCC3)c(OC)c(OCCN3CCOCC3)c2)cc1 10.1021/jm980504w
10238141 195849 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 429 5 1 6 4.2 COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2ccccc21 10.1016/S0960-894X(97)00319-3
CHEMBL55853 195849 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 429 5 1 6 4.2 COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2ccccc21 10.1016/S0960-894X(97)00319-3
44283270 167879 None 0 Pig Binding pIC50 = 5.7 5.7 - 0
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 580 12 5 5 3.8 CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL431124 167879 None 0 Pig Binding pIC50 = 5.7 5.7 - 0
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 580 12 5 5 3.8 CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1016/0960-894X(95)00237-N
10357554 97562 None 1 Human Binding pIC50 = 4.7 4.7 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1021/jm00029a001
CHEMBL27065 97562 None 1 Human Binding pIC50 = 4.7 4.7 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1021/jm00029a001
44278161 99802 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 569 10 1 8 6.9 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OCc4ccccc4)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL285380 99802 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 569 10 1 8 6.9 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OCc4ccccc4)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
10357554 97562 None 1 Rat Binding pIC50 = 4.7 4.7 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1021/jm00008a013
CHEMBL27065 97562 None 1 Rat Binding pIC50 = 4.7 4.7 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1021/jm00008a013
10495634 207926 None 0 Rat Binding pIC50 = 4.7 4.7 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 316 6 1 2 4.8 OC/C(=C/c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
CHEMBL96836 207926 None 0 Rat Binding pIC50 = 4.7 4.7 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 316 6 1 2 4.8 OC/C(=C/c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
44276966 106854 None 0 Rat Binding pIC50 = 4.7 4.7 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 352 5 1 5 2.9 COc1cccc(Cn2[nH]c(C)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144846 106854 None 0 Rat Binding pIC50 = 4.7 4.7 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 352 5 1 5 2.9 COc1cccc(Cn2[nH]c(C)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
44386894 62479 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 412 7 2 6 2.1 COc1ccc([C@@H]2[C@@H](CC(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(N)=O)cc1 10.1021/jm031041j
CHEMBL177999 62479 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 412 7 2 6 2.1 COc1ccc([C@@H]2[C@@H](CC(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(N)=O)cc1 10.1021/jm031041j
11795139 166535 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 398 6 2 6 1.8 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(N)=O)cc1 10.1021/jm9505369
CHEMBL427935 166535 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 398 6 2 6 1.8 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(N)=O)cc1 10.1021/jm9505369
10212163 130094 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 696 11 2 13 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL367767 130094 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 696 11 2 13 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
23445256 60187 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 470 6 1 7 4.1 Cc1noc(NS(=O)(=O)c2ccsc2CCc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
CHEMBL173982 60187 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 470 6 1 7 4.1 Cc1noc(NS(=O)(=O)c2ccsc2CCc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
10604119 11455 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 636 12 2 7 5.8 COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 10.1021/jm990171i
CHEMBL1180361 11455 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 636 12 2 7 5.8 COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 10.1021/jm990171i
CHEMBL123654 11455 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 636 12 2 7 5.8 COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 10.1021/jm990171i
44325305 207465 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 426 10 2 5 5.3 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C(=O)O 10.1021/jm9707131
CHEMBL94279 207465 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 426 10 2 5 5.3 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C(=O)O 10.1021/jm9707131
10005597 119816 None 0 Rat Binding pIC50 = 7.7 7.7 - 1
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 10.1021/jm031041j
CHEMBL348407 119816 None 0 Rat Binding pIC50 = 7.7 7.7 - 1
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 10.1021/jm031041j
10005597 119816 None 0 Rat Binding pIC50 = 7.7 7.7 - 1
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL348407 119816 None 0 Rat Binding pIC50 = 7.7 7.7 - 1
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL433349 213635 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44314890 105074 None 0 Pig Binding pIC50 = 7.7 7.7 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 12 5 4 5.0 CC(C)CC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL311384 105074 None 0 Pig Binding pIC50 = 7.7 7.7 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 12 5 4 5.0 CC(C)CC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
3539 4139 None 83 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 10.1016/j.bmcl.2016.06.014
9910224 4139 None 83 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 10.1016/j.bmcl.2016.06.014
CHEMBL1628688 4139 None 83 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 10.1016/j.bmcl.2016.06.014
DB06629 4139 None 83 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 10.1016/j.bmcl.2016.06.014
10168597 61335 None 0 Human Binding pIC50 = 7.7 7.7 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cccnc1 10.1016/s0960-894x(02)01084-3
CHEMBL176741 61335 None 0 Human Binding pIC50 = 7.7 7.7 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cccnc1 10.1016/s0960-894x(02)01084-3
10673969 62103 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 538 10 3 7 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL177546 62103 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 538 10 3 7 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
10138169 99359 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 440 6 1 8 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm000349x
CHEMBL282470 99359 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 440 6 1 8 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm000349x
CHEMBL342615 211673 None 0 Pig Binding pIC50 = 7.7 7.7 - 0
Inhibitory effect against porcine Endothelin A receptorInhibitory effect against porcine Endothelin A receptor
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL342615 211673 None 0 Pig Binding pIC50 = 7.7 7.7 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10527706 96999 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 454 8 1 6 3.1 CCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL266594 96999 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 454 8 1 6 3.1 CCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
44439114 161628 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 993 32 2 15 7.3 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOc2ccc(CCC(=O)N(C)Cc3cc(-c4ncco4)ccc3-c3ccccc3S(=O)(=O)Nc3ccno3)cc2)cc1 10.1016/j.bmcl.2006.10.009
CHEMBL413001 161628 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 993 32 2 15 7.3 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOc2ccc(CCC(=O)N(C)Cc3cc(-c4ncco4)ccc3-c3ccccc3S(=O)(=O)Nc3ccno3)cc2)cc1 10.1016/j.bmcl.2006.10.009
18738889 87964 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 562 8 1 8 4.9 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)OC)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL23418 87964 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 562 8 1 8 4.9 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)OC)cc21 10.1016/s0960-894x(01)00660-6
10310877 203887 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 473 8 1 7 5.9 CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1ccc2nsnc2c1 10.1016/s0960-894x(97)10151-2
CHEMBL68896 203887 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 473 8 1 7 5.9 CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1ccc2nsnc2c1 10.1016/s0960-894x(97)10151-2
CHEMBL136210 208735 None 0 Pig Binding pIC50 = 6.7 6.7 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
21462927 120240 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 500 7 1 8 5.1 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc([N+](=O)[O-])ccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL352241 120240 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 500 7 1 8 5.1 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc([N+](=O)[O-])ccc23)cc1 10.1016/s0960-894x(99)00040-2
10086660 99158 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 309 6 2 5 2.9 CCCNc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1 10.1021/jm00008a013
CHEMBL281199 99158 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 309 6 2 5 2.9 CCCNc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1 10.1021/jm00008a013
44279308 100131 None 0 Pig Binding pIC50 = 5.7 5.7 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 521 12 6 4 3.3 Cc1cccc(NC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCC(=O)O)c1 10.1016/0960-894X(95)00221-E
CHEMBL287676 100131 None 0 Pig Binding pIC50 = 5.7 5.7 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 521 12 6 4 3.3 Cc1cccc(NC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCC(=O)O)c1 10.1016/0960-894X(95)00221-E
44279307 108012 None 0 Pig Binding pIC50 = 5.7 5.7 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 541 12 6 4 3.7 CC(C)C[C@H](NC(=O)Nc1cccc(Cl)c1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31944 108012 None 0 Pig Binding pIC50 = 5.7 5.7 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 541 12 6 4 3.7 CC(C)C[C@H](NC(=O)Nc1cccc(Cl)c1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL319537 211217 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10621049 207241 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 400 6 1 3 5.6 OC/C(=C/c1cc(OCc2ccsc2)ccc1Br)c1ccccc1 10.1021/jm970847e
CHEMBL92876 207241 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 400 6 1 3 5.6 OC/C(=C/c1cc(OCc2ccsc2)ccc1Br)c1ccccc1 10.1021/jm970847e
44213278 106847 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 406 5 1 5 3.6 COc1ccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)cc1 10.1016/s0960-894x(00)00232-8
CHEMBL3144799 106847 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 406 5 1 5 3.6 COc1ccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)cc1 10.1016/s0960-894x(00)00232-8
10719007 11239 None 0 Human Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 465 6 1 9 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)C(C#N)c2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
CHEMBL1178895 11239 None 0 Human Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 465 6 1 9 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)C(C#N)c2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
CHEMBL48448 11239 None 0 Human Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 465 6 1 9 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)C(C#N)c2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
10626054 131346 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 530 11 6 4 4.2 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NCc2ccccc2)nc1C(=O)O 10.1021/jm950592+
CHEMBL368788 131346 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 530 11 6 4 4.2 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NCc2ccccc2)nc1C(=O)O 10.1021/jm950592+
CHEMBL1206645 208606 None 0 Pig Binding pIC50 = 4.7 4.7 - 0
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL None None None CC(C)C[C@@H](NC(=O)N1CCCCCC1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00087a001
CHEMBL290454 208606 None 0 Pig Binding pIC50 = 4.7 4.7 - 0
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL None None None CC(C)C[C@@H](NC(=O)N1CCCCCC1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00087a001
10742968 12359 None 0 Human Binding pIC50 = 4.7 4.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 469 7 1 8 4.1 Cc1noc(NS(=O)(=O)c2ccsc2C(Cc2ccc3c(c2)OCO3)N(C)C)c1Cl 10.1021/jm9700068
CHEMBL1185472 12359 None 0 Human Binding pIC50 = 4.7 4.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 469 7 1 8 4.1 Cc1noc(NS(=O)(=O)c2ccsc2C(Cc2ccc3c(c2)OCO3)N(C)C)c1Cl 10.1021/jm9700068
CHEMBL416453 12359 None 0 Human Binding pIC50 = 4.7 4.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 469 7 1 8 4.1 Cc1noc(NS(=O)(=O)c2ccsc2C(Cc2ccc3c(c2)OCO3)N(C)C)c1Cl 10.1021/jm9700068
44368481 121518 None 0 Pig Binding pIC50 = 4.7 4.7 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 435 9 2 7 2.8 CCOC(=O)CN(Cc1cc2c(cc1Cl)OCO2)C(Cc1ccc(O)cc1)C(=O)O 10.1016/s0960-894x(01)00009-9
CHEMBL358444 121518 None 0 Pig Binding pIC50 = 4.7 4.7 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 435 9 2 7 2.8 CCOC(=O)CN(Cc1cc2c(cc1Cl)OCO2)C(Cc1ccc(O)cc1)C(=O)O 10.1016/s0960-894x(01)00009-9
10576888 170843 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 6 3 7 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2C(=O)O)c1Br 10.1021/jm9608366
CHEMBL44539 170843 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 6 3 7 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2C(=O)O)c1Br 10.1021/jm9608366
23445284 112800 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 440 5 1 5 5.4 Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(C(C)C)cc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL330674 112800 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 440 5 1 5 5.4 Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(C(C)C)cc2)c1Br 10.1016/S0960-894X(96)00496-9
23445458 60298 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 5 1 7 4.5 Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
CHEMBL174363 60298 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 5 1 7 4.5 Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
5344 173471 None 101 Human Binding pIC50 = 4.7 4.7 - 1
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C nan
CHEMBL453 173471 None 101 Human Binding pIC50 = 4.7 4.7 - 1
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C nan
44385412 131376 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 711 14 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(Cc2ccc3c(c2)OCO3)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL368945 131376 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 711 14 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(Cc2ccc3c(c2)OCO3)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
18184249 128470 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 662 13 2 11 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL366628 128470 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 662 13 2 11 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL303185 210915 None 0 Pig Binding pIC50 = 7.7 7.7 - 0
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00089a028
10696818 9648 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 15 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC(CC)CC 10.1021/jm980217s
CHEMBL112770 9648 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 15 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC(CC)CC 10.1021/jm980217s
CHEMBL303185 210915 None 0 Pig Binding pIC50 = 7.7 7.7 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm9600914
10792711 114789 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 548 9 2 6 5.2 CCc1cc(F)cc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL333972 114789 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 548 9 2 6 5.2 CCc1cc(F)cc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
9917706 129737 None 0 Human Binding pIC50 = 7.7 7.7 - 2
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 659 15 2 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/j.bmcl.2016.06.014
CHEMBL367444 129737 None 0 Human Binding pIC50 = 7.7 7.7 - 2
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 659 15 2 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/j.bmcl.2016.06.014
18738881 79581 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 534 7 2 7 4.4 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(=O)O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL2114305 79581 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 534 7 2 7 4.4 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(=O)O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
443289 710 None 47 Human Binding pIC50 = 7.7 7.7 2 3
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL None None None None 10.1021/jm030528p
997 710 None 47 Human Binding pIC50 = 7.7 7.7 2 3
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL None None None None 10.1021/jm030528p
CHEMBL314691 710 None 47 Human Binding pIC50 = 7.7 7.7 2 3
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL None None None None 10.1021/jm030528p
DB12054 710 None 47 Human Binding pIC50 = 7.7 7.7 2 3
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL None None None None 10.1021/jm030528p
9886303 59535 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 383 7 1 5 4.5 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1F 10.1021/jm990378b
CHEMBL171638 59535 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 383 7 1 5 4.5 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1F 10.1021/jm990378b
44293761 169212 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 549 12 2 8 4.6 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL440853 169212 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 549 12 2 8 4.6 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10908075 11741 None 0 Pig Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 591 9 1 8 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3cccc4ccccc34)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL1181549 11741 None 0 Pig Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 591 9 1 8 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3cccc4ccccc34)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL177373 11741 None 0 Pig Binding pIC50 = 7.7 7.7 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 591 9 1 8 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3cccc4ccccc34)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
10302118 60422 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 533 9 2 10 3.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL175111 60422 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 533 9 2 10 3.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
135512539 128472 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 615 11 2 13 4.4 C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL366652 128472 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 615 11 2 13 4.4 C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
9864880 102386 None 0 Rat Binding pIC50 = 7.7 7.7 - 1
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 384 4 1 6 3.7 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc4nsnc4c3)cccc12 10.1016/s0960-894x(97)10151-2
CHEMBL303902 102386 None 0 Rat Binding pIC50 = 7.7 7.7 - 1
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 384 4 1 6 3.7 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc4nsnc4c3)cccc12 10.1016/s0960-894x(97)10151-2
443289 710 None 47 Pig Binding pIC50 = 7.7 7.7 - 3
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None None 10.1016/0960-894X(95)00237-N
997 710 None 47 Pig Binding pIC50 = 7.7 7.7 - 3
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None None 10.1016/0960-894X(95)00237-N
CHEMBL314691 710 None 47 Pig Binding pIC50 = 7.7 7.7 - 3
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None None 10.1016/0960-894X(95)00237-N
DB12054 710 None 47 Pig Binding pIC50 = 7.7 7.7 - 3
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None None 10.1016/0960-894X(95)00237-N
10578601 129043 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 550 10 4 5 4.7 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)N(C)C(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL367033 129043 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 550 10 4 5 4.7 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)N(C)C(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
9917706 129737 None 0 Human Binding pIC50 = 7.7 7.7 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 659 15 2 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL367444 129737 None 0 Human Binding pIC50 = 7.7 7.7 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 659 15 2 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL336033 211572 None 1 Pig Binding pIC50 = 7.7 7.7 - 0
Inhibitory effect against porcine Endothelin A receptorInhibitory effect against porcine Endothelin A receptor
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL336033 211572 None 1 Pig Binding pIC50 = 7.7 7.7 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL170121 208839 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL None None None CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCC(=O)O 10.1016/0960-894X(95)00144-I
11070564 203398 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1)O2 10.1021/jm010382z
CHEMBL65494 203398 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1)O2 10.1021/jm010382z
122044 10171 None 51 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of 125I-ET1 from human smooth muscle ETA receptor expressed in fall armyworm sf9 cell membranesDisplacement of 125I-ET1 from human smooth muscle ETA receptor expressed in fall armyworm sf9 cell membranes
ChEMBL 473 9 2 8 3.7 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 10.1016/j.bmcl.2016.06.014
CHEMBL115951 10171 None 51 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of 125I-ET1 from human smooth muscle ETA receptor expressed in fall armyworm sf9 cell membranesDisplacement of 125I-ET1 from human smooth muscle ETA receptor expressed in fall armyworm sf9 cell membranes
ChEMBL 473 9 2 8 3.7 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 10.1016/j.bmcl.2016.06.014
10571812 128646 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 380 7 1 6 4.1 Cc1ccccc1C(Oc1cc(OCc2ccsn2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL366788 128646 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 380 7 1 6 4.1 Cc1ccccc1C(Oc1cc(OCc2ccsn2)ccc1C#N)C(=O)O 10.1021/jm990378b
2802888 60555 None 10 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cellsInhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cells
ChEMBL 414 9 4 5 2.5 CC(C)C(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccc(O)cc1)C(=O)O 10.1021/jm031041j
CHEMBL175916 60555 None 10 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cellsInhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cells
ChEMBL 414 9 4 5 2.5 CC(C)C(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccc(O)cc1)C(=O)O 10.1021/jm031041j
10789279 206563 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 441 10 1 6 4.1 CCCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL8878 206563 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 441 10 1 6 4.1 CCCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10554384 169243 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 537 10 4 6 4.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL441112 169243 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 537 10 4 6 4.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
10554384 169243 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 537 10 4 6 4.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL441112 169243 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 537 10 4 6 4.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL2370254 209816 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10024044 7837 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 402 6 1 5 4.1 COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
CHEMBL10897 7837 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 402 6 1 5 4.1 COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
11732155 202664 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 402 4 1 5 4.4 COc1ccccc1C1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
CHEMBL61460 202664 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 402 4 1 5 4.4 COc1ccccc1C1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
CHEMBL2304014 209468 None 0 Pig Binding pIC50 = 5.7 5.7 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(C#N)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O 10.1021/jm9600914
443289 710 None 47 Pig Binding pIC50 = 4.7 4.7 - 3
Compound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscleCompound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscle
ChEMBL None None None None 10.1021/jm00087a001
997 710 None 47 Pig Binding pIC50 = 4.7 4.7 - 3
Compound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscleCompound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscle
ChEMBL None None None None 10.1021/jm00087a001
CHEMBL314691 710 None 47 Pig Binding pIC50 = 4.7 4.7 - 3
Compound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscleCompound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscle
ChEMBL None None None None 10.1021/jm00087a001
DB12054 710 None 47 Pig Binding pIC50 = 4.7 4.7 - 3
Compound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscleCompound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscle
ChEMBL None None None None 10.1021/jm00087a001
10647488 176920 None 0 Human Binding pIC50 = 4.7 4.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 456 6 2 8 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(C)(O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
CHEMBL46195 176920 None 0 Human Binding pIC50 = 4.7 4.7 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 456 6 2 8 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(C)(O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
44320488 106983 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 438 5 1 5 5.7 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1C1CCCCC1 10.1016/s0960-894x(00)00513-8
CHEMBL315175 106983 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 438 5 1 5 5.7 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1C1CCCCC1 10.1016/s0960-894x(00)00513-8
10766198 162883 None 0 Human Binding pIC50 = 6.6 6.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 6 2 6 3.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)NCc2ccccc2)c1Br 10.1021/jm9608366
CHEMBL417358 162883 None 0 Human Binding pIC50 = 6.6 6.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 6 2 6 3.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)NCc2ccccc2)c1Br 10.1021/jm9608366
76324075 85838 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL 340 4 1 6 4.0 Cc1c(C(=O)O)oc2cccc(OCc3ccc4nsnc4c3)c12 10.1007/s00044-013-0542-3
CHEMBL2296899 85838 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL 340 4 1 6 4.0 Cc1c(C(=O)O)oc2cccc(OCc3ccc4nsnc4c3)c12 10.1007/s00044-013-0542-3
151174 202718 None 45 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 605 12 3 13 3.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO 10.1021/jm030528p
CHEMBL61780 202718 None 45 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 605 12 3 13 3.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO 10.1021/jm030528p
10810505 59509 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 392 7 1 5 4.2 Cc1ccccc1C(Oc1cc(OCc2ccnc(F)c2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL171513 59509 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 392 7 1 5 4.2 Cc1ccccc1C(Oc1cc(OCc2ccnc(F)c2)ccc1C#N)C(=O)O 10.1021/jm990378b
10282163 60411 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 599 11 2 12 3.9 C#CCOc1nc(-c2ccnc(-c3nn[nH]n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL175057 60411 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 599 11 2 12 3.9 C#CCOc1nc(-c2ccnc(-c3nn[nH]n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10838921 206344 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 494 7 1 6 4.1 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)C2CCCCC2)cc1 10.1021/jm9505369
CHEMBL8736 206344 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 494 7 1 6 4.1 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)C2CCCCC2)cc1 10.1021/jm9505369
44279338 106692 None 0 Pig Binding pIC50 = 6.6 6.6 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 487 11 6 4 2.3 CC(C)C[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31436 106692 None 0 Pig Binding pIC50 = 6.6 6.6 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 487 11 6 4 2.3 CC(C)C[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL97431 215922 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
18617403 205271 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 394 3 1 4 3.3 Cc1noc(NS(=O)(=O)c2cccc(Br)c2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL79031 205271 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 394 3 1 4 3.3 Cc1noc(NS(=O)(=O)c2cccc(Br)c2)c1Br 10.1016/0960-894X(96)00441-6
18617374 205514 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 350 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80808 205514 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 350 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL262782 210548 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Binding affinity for Endothelin A receptor was determined in murine 3T3 cellsBinding affinity for Endothelin A receptor was determined in murine 3T3 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCNC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(00)80326-1
122044 10171 None 51 Rat Binding pIC50 = 6.6 6.6 - 0
In vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptorIn vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptor
ChEMBL 473 9 2 8 3.7 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 10.1021/jm0102304
CHEMBL115951 10171 None 51 Rat Binding pIC50 = 6.6 6.6 - 0
In vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptorIn vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptor
ChEMBL 473 9 2 8 3.7 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 10.1021/jm0102304
44327728 207893 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 505 5 1 8 2.1 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(Br)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL96662 207893 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 505 5 1 8 2.1 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(Br)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
44327354 208054 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 427 5 1 8 1.4 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccccc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL97595 208054 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 427 5 1 8 1.4 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccccc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
10579210 168589 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 585 10 4 6 5.4 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCc3ccccc32)nc1C(=O)O 10.1021/jm950592+
CHEMBL435901 168589 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 585 10 4 6 5.4 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCc3ccccc32)nc1C(=O)O 10.1021/jm950592+
CHEMBL1791007 208911 None 0 Pig Binding pIC50 = 6.6 6.6 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC[C@@H](C)[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL423941 213319 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
The compound was tested for the binding affinity against eEndothelin A receptor in murine 3T3 cells using [125I]ET1 as a radioligandThe compound was tested for the binding affinity against eEndothelin A receptor in murine 3T3 cells using [125I]ET1 as a radioligand
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
21462925 119937 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 470 6 2 7 4.8 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc(N)ccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL349556 119937 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 470 6 2 7 4.8 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc(N)ccc23)cc1 10.1016/s0960-894x(99)00040-2
10766396 110577 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 460 8 1 4 4.6 CCCN(C)C(=O)CN1C[C@H](c2ccc3ccccc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL325418 110577 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 460 8 1 4 4.6 CCCN(C)C(=O)CN1C[C@H](c2ccc3ccccc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10837666 169886 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 460 8 1 4 4.6 CCCN(C)C(=O)CN1C[C@H](c2cccc3ccccc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL444061 169886 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 460 8 1 4 4.6 CCCN(C)C(=O)CN1C[C@H](c2cccc3ccccc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
44284290 12945 None 0 Pig Binding pIC50 = 5.6 5.6 - 0
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 589 13 4 5 3.9 CC(C)C[C@@H](NC(=O)C1CCCCC1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccn1)C(=O)O 10.1021/jm00087a001
CHEMBL1189291 12945 None 0 Pig Binding pIC50 = 5.6 5.6 - 0
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 589 13 4 5 3.9 CC(C)C[C@@H](NC(=O)C1CCCCC1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccn1)C(=O)O 10.1021/jm00087a001
CHEMBL538475 12945 None 0 Pig Binding pIC50 = 5.6 5.6 - 0
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 589 13 4 5 3.9 CC(C)C[C@@H](NC(=O)C1CCCCC1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccn1)C(=O)O 10.1021/jm00087a001
44320782 107070 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 482 7 1 6 5.8 COc1ccc(-c2nn(CC3CCCCC3)c(C(=O)O)c2Cc2cc3c(cc2Cl)OCO3)cc1 10.1016/s0960-894x(00)00513-8
CHEMBL315788 107070 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 482 7 1 6 5.8 COc1ccc(-c2nn(CC3CCCCC3)c(C(=O)O)c2Cc2cc3c(cc2Cl)OCO3)cc1 10.1016/s0960-894x(00)00513-8
44266629 4417 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 387 4 1 5 4.7 COc1ccc(-n2c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3ccccc32)cc1 10.1016/0960-894X(96)00170-9
CHEMBL10151 4417 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 387 4 1 5 4.7 COc1ccc(-n2c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3ccccc32)cc1 10.1016/0960-894X(96)00170-9
CHEMBL2304017 209471 None 0 Pig Binding pIC50 = 4.6 4.6 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None CSC(C)(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(C#N)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O 10.1021/jm9600914
44278270 162041 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Compound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptorCompound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptor
ChEMBL 300 4 1 4 4.3 COc1cccc(Sc2c(C(=O)O)oc3ccccc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL416019 162041 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Compound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptorCompound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptor
ChEMBL 300 4 1 4 4.3 COc1cccc(Sc2c(C(=O)O)oc3ccccc23)c1 10.1016/0960-894X(96)00232-6
23445430 61064 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 438 5 1 5 5.1 Cc1ccc(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
CHEMBL176422 61064 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 438 5 1 5 5.1 Cc1ccc(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
10530424 62088 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 9 4 5 4.3 Cc1c(C(=O)O)nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)n1C 10.1021/jm950592+
CHEMBL177502 62088 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 9 4 5 4.3 Cc1c(C(=O)O)nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)n1C 10.1021/jm950592+
23445438 61497 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 470 6 1 7 4.1 Cc1noc(NS(=O)(=O)c2sccc2CCc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
CHEMBL177070 61497 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 470 6 1 7 4.1 Cc1noc(NS(=O)(=O)c2sccc2CCc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
44384826 59974 None 0 Human Binding pIC50 = 6.6 6.6 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 561 10 1 9 5.8 C/C=C/COc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL173366 59974 None 0 Human Binding pIC50 = 6.6 6.6 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 561 10 1 9 5.8 C/C=C/COc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
9896251 98771 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Compound was evaluated for inhibitory activity against human Endothelin A receptor (ETA)Compound was evaluated for inhibitory activity against human Endothelin A receptor (ETA)
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm020138n
CHEMBL278176 98771 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Compound was evaluated for inhibitory activity against human Endothelin A receptor (ETA)Compound was evaluated for inhibitory activity against human Endothelin A receptor (ETA)
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm020138n
127034758 136368 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 681 12 1 8 7.7 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)cc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1039/C4MD00499J
CHEMBL3734968 136368 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 681 12 1 8 7.7 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)cc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1039/C4MD00499J
10576379 101269 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 471 6 2 7 3.9 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
CHEMBL296291 101269 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 471 6 2 7 3.9 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
10281192 61075 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 561 11 2 10 4.2 C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL176482 61075 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 561 11 2 10 4.2 C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
9896251 98771 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL278176 98771 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
44404967 135416 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 680 12 1 8 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 10.1021/jm058225d
CHEMBL372814 135416 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 680 12 1 8 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 10.1021/jm058225d
CHEMBL343582 211699 None 0 Pig Binding pIC50 = 7.6 7.6 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](c2ccccc2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
42630654 18402 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 545 10 2 8 4.3 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCOC)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1271531 18402 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 545 10 2 8 4.3 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCOC)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
42630654 18402 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 545 10 2 8 4.3 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCOC)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271531 18402 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 545 10 2 8 4.3 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCOC)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
11763363 110505 None 0 Pig Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2cnccn2)c1 10.1021/jm0102304
CHEMBL324943 110505 None 0 Pig Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2cnccn2)c1 10.1021/jm0102304
443289 710 None 47 Human Binding pIC50 = 7.6 7.6 2 3
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL None None None None 10.1016/j.bmcl.2010.08.074
997 710 None 47 Human Binding pIC50 = 7.6 7.6 2 3
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL None None None None 10.1016/j.bmcl.2010.08.074
CHEMBL314691 710 None 47 Human Binding pIC50 = 7.6 7.6 2 3
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL None None None None 10.1016/j.bmcl.2010.08.074
DB12054 710 None 47 Human Binding pIC50 = 7.6 7.6 2 3
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL None None None None 10.1016/j.bmcl.2010.08.074
10915215 100801 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@@H](c1ccc3c(c1)OCO3)O2 10.1021/jm031041j
CHEMBL293161 100801 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@@H](c1ccc3c(c1)OCO3)O2 10.1021/jm031041j
18617389 163476 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 408 3 1 4 3.6 Cc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL420029 163476 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 408 3 1 4 3.6 Cc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
10646375 97055 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)ccc3OC)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL267096 97055 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)ccc3OC)=C2Cc2ccccc2)cc1 10.1021/jm9606507
10915215 100801 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@@H](c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL293161 100801 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@@H](c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
44327727 168195 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 503 6 1 8 3.0 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL433373 168195 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 503 6 1 8 3.0 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
44266640 98115 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 459 4 1 8 4.2 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc3c(cc2n1Cc1ccc2c(c1)OCO2)OCO3 10.1016/0960-894X(96)00170-9
CHEMBL273529 98115 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 459 4 1 8 4.2 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc3c(cc2n1Cc1ccc2c(c1)OCO2)OCO3 10.1016/0960-894X(96)00170-9
CHEMBL335780 211560 None 0 Pig Binding pIC50 = 6.6 6.6 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL343768 211700 None 0 Pig Binding pIC50 = 6.6 6.6 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10448516 99210 None 1 Rat Binding pIC50 = 5.6 5.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3cc(N)ccc23)c1C 10.1021/jm00008a013
CHEMBL281511 99210 None 1 Rat Binding pIC50 = 5.6 5.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3cc(N)ccc23)c1C 10.1021/jm00008a013
CHEMBL413880 213092 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptorBinding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor
ChEMBL None None None NC(=O)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00084-7
44314579 102915 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
CHEMBL306123 102915 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
10618166 59849 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 355 7 1 6 4.0 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccco1 10.1021/jm990378b
CHEMBL172880 59849 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 355 7 1 6 4.0 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccco1 10.1021/jm990378b
10151203 100798 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 429 5 1 6 4.2 COc1ccc(Cn2c(=O)c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3ccccc32)cc1 10.1016/S0960-894X(97)00319-3
CHEMBL293151 100798 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 429 5 1 6 4.2 COc1ccc(Cn2c(=O)c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3ccccc32)cc1 10.1016/S0960-894X(97)00319-3
10448516 99210 None 1 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3cc(N)ccc23)c1C 10.1021/jm00004a012
CHEMBL281511 99210 None 1 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3cc(N)ccc23)c1C 10.1021/jm00004a012
44266568 98095 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 493 7 1 6 6.3 COc1ccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OCc4ccccc4)cc23)cc1 10.1016/0960-894X(96)00170-9
CHEMBL273410 98095 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 493 7 1 6 6.3 COc1ccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OCc4ccccc4)cc23)cc1 10.1016/0960-894X(96)00170-9
10313743 95544 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3c(N)cccc3c2)c1C 10.1021/jm00008a013
CHEMBL25756 95544 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3c(N)cccc3c2)c1C 10.1021/jm00008a013
10314989 99859 None 1 Rat Binding pIC50 = 4.6 4.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 336 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2cccc3c(Cl)cccc23)c1C 10.1021/jm00008a013
CHEMBL285814 99859 None 1 Rat Binding pIC50 = 4.6 4.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 336 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2cccc3c(Cl)cccc23)c1C 10.1021/jm00008a013
127035379 136505 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 691 13 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736248 136505 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 691 13 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10507191 128790 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 565 10 4 5 5.6 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C2CC2)s1 10.1021/jm950591h
CHEMBL366911 128790 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 565 10 4 5 5.6 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C2CC2)s1 10.1021/jm950591h
CHEMBL2369710 209651 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00152-J
10313743 95544 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3c(N)cccc3c2)c1C 10.1021/jm00004a012
CHEMBL25756 95544 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3c(N)cccc3c2)c1C 10.1021/jm00004a012
10813822 96968 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 460 5 2 5 4.5 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)Nc2ccccc2)cc1 10.1021/jm9505369
CHEMBL266336 96968 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 460 5 2 5 4.5 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)Nc2ccccc2)cc1 10.1021/jm9505369
9915028 9409 None 18 Human Binding pIC50 = 4.6 4.6 28183 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
CHEMBL111612 9409 None 18 Human Binding pIC50 = 4.6 4.6 28183 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
CHEMBL4761843 9409 None 18 Human Binding pIC50 = 4.6 4.6 28183 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
10218058 81667 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 523 12 2 10 3.1 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL2163695 81667 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 523 12 2 10 3.1 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL97470 215923 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10600668 5156 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1cc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc(OC)c1OC 10.1021/jm9606507
CHEMBL10589 5156 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1cc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc(OC)c1OC 10.1021/jm9606507
10625269 14454 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2ccc(C)cc2C)cc1 10.1021/jm990170q
CHEMBL120106 14454 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2ccc(C)cc2C)cc1 10.1021/jm990170q
10792783 60374 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 551 10 3 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N(C)C2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL174699 60374 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 551 10 3 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N(C)C2CCCCC2)nc1C(=O)O 10.1021/jm9505932
10218058 81667 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 523 12 2 10 3.1 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1021/jm3009103
CHEMBL2163695 81667 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 523 12 2 10 3.1 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1021/jm3009103
10951918 110871 None 0 Pig Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 567 11 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2SCCOc2ncccn2)c1 10.1021/jm0102304
CHEMBL326105 110871 None 0 Pig Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 567 11 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2SCCOc2ncccn2)c1 10.1021/jm0102304
44327656 141787 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 977 25 9 8 4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(F)(F)F)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL386181 141787 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 977 25 9 8 4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(F)(F)F)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL21253 209273 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Binding affinity for Endothelin A receptor was determined in murine 3T3 cellsBinding affinity for Endothelin A receptor was determined in murine 3T3 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](N)CCCNC(=O)[C@H](Cc1ccccc1)NC(C)=O)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/S0960-894X(00)80326-1
10862228 202959 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 398 7 1 6 4.2 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC)cc21 10.1021/jm010382z
CHEMBL63000 202959 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 398 7 1 6 4.2 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC)cc21 10.1021/jm010382z
CHEMBL405677 212572 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptorBinding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor
ChEMBL None None None CC(=O)[C@@H](Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00084-7
44266552 4511 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/s0960-894x(97)10151-2
CHEMBL10218 4511 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/s0960-894x(97)10151-2
56671734 63327 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)NCC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC 10.1021/jm970161m
CHEMBL1793932 63327 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)NCC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC 10.1021/jm970161m
44266552 4511 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1021/jm0300429
CHEMBL10218 4511 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1021/jm0300429
CHEMBL341443 211638 None 0 Pig Binding pIC50 = 6.6 6.6 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44368824 96825 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1595 31 19 20 0.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
77282142 96825 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1595 31 19 20 0.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL265164 96825 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1595 31 19 20 0.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL412460 212989 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
18617363 164558 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL421523 164558 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL37860 212260 None 0 Pig Binding pIC50 = 5.6 5.6 - 0
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL None None None CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccn1)C(=O)O 10.1021/jm00087a001
44368905 161820 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1623 31 19 20 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
77282145 161820 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1623 31 19 20 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL414448 161820 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1623 31 19 20 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
10792784 59593 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 551 10 4 5 5.4 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C(C)C)o1 10.1021/jm950591h
CHEMBL171910 59593 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 551 10 4 5 5.4 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C(C)C)o1 10.1021/jm950591h
44309488 204007 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 471 7 1 8 5.1 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nonc2c1 10.1016/s0960-894x(97)10151-2
CHEMBL69664 204007 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 471 7 1 8 5.1 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nonc2c1 10.1016/s0960-894x(97)10151-2
44327726 207890 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 495 6 1 8 2.7 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc3c(cc2=O)CCC3)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL96644 207890 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 495 6 1 8 2.7 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc3c(cc2=O)CCC3)cc1 10.1016/S0960-894X(96)00617-8
44309488 204007 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 471 7 1 8 5.1 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nonc2c1 10.1021/jm0300429
CHEMBL69664 204007 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 471 7 1 8 5.1 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nonc2c1 10.1021/jm0300429
10038537 59971 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 266 3 2 5 0.8 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)CC1 10.1016/s0960-894x(00)00136-0
CHEMBL173336 59971 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 266 3 2 5 0.8 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)CC1 10.1016/s0960-894x(00)00136-0
44279479 99285 None 1 Pig Binding pIC50 = 4.6 4.6 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membrane was determinedBinding affinity against ETA receptor in porcine aortic smooth muscle membrane was determined
ChEMBL 516 14 6 5 1.8 CC(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(=O)O)C(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL281963 99285 None 1 Pig Binding pIC50 = 4.6 4.6 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membrane was determinedBinding affinity against ETA receptor in porcine aortic smooth muscle membrane was determined
ChEMBL 516 14 6 5 1.8 CC(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(=O)O)C(=O)O 10.1016/0960-894X(95)00221-E
44279439 107376 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 534 3 2 3 6.2 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(C(F)(F)F)cc3C(F)(F)F)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL31781 107376 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 534 3 2 3 6.2 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(C(F)(F)F)cc3C(F)(F)F)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL137569 208743 None 0 Pig Binding pIC50 = 4.6 4.6 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10787482 96959 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 405 4 1 4 3.9 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)nc3)cccc12 10.1021/jm9604585
CHEMBL266277 96959 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 405 4 1 4 3.9 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)nc3)cccc12 10.1021/jm9604585
10740139 202953 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)nn3)cccc12 10.1021/jm9604585
CHEMBL6297 202953 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)nn3)cccc12 10.1021/jm9604585
18617288 205144 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 316 3 1 4 2.5 Cc1noc(NS(=O)(=O)c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL78080 205144 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 316 3 1 4 2.5 Cc1noc(NS(=O)(=O)c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
10646522 203390 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 434 5 1 5 3.8 CCc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL6543 203390 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 434 5 1 5 3.8 CCc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
22998439 203094 None 0 Human Binding pIC50 = 5.6 5.6 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 392 5 1 7 3.7 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/S0960-894X(97)00367-3
CHEMBL63938 203094 None 0 Human Binding pIC50 = 5.6 5.6 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 392 5 1 7 3.7 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/S0960-894X(97)00367-3
10650368 60365 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 553 10 5 7 3.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(O)CC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL174635 60365 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 553 10 5 7 3.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(O)CC2)nc1C(=O)O 10.1021/jm950592+
10789715 113096 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 450 8 1 5 4.2 CCCN(C)C(=O)CN1C[C@H](c2cccc3occc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL331375 113096 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 450 8 1 5 4.2 CCCN(C)C(=O)CN1C[C@H](c2cccc3occc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10575552 111307 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 450 8 1 5 4.2 CCCN(C)C(=O)CN1C[C@H](c2ccc3ccoc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL326690 111307 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 450 8 1 5 4.2 CCCN(C)C(=O)CN1C[C@H](c2ccc3ccoc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
9871561 174798 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 527 10 2 8 4.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cc2)nc(C(F)(F)F)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4562189 174798 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 527 10 2 8 4.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cc2)nc(C(F)(F)F)nc1OCCO 10.1016/j.bmcl.2016.06.014
44314657 103201 None 0 Pig Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 619 13 5 4 4.3 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCC1)C(=O)O 10.1021/jm9600914
CHEMBL308383 103201 None 0 Pig Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 619 13 5 4 4.3 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCC1)C(=O)O 10.1021/jm9600914
10288020 14627 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 430 7 1 6 4.7 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1205067 14627 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 430 7 1 6 4.7 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL48881 14627 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 430 7 1 6 4.7 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
11796594 207376 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 424 10 1 5 5.8 CC(=O)c1ccc(OCc2ccsc2)cc1OC(CCC(=O)O)c1ccccc1C 10.1021/jm9707131
CHEMBL93776 207376 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 424 10 1 5 5.8 CC(=O)c1ccc(OCc2ccsc2)cc1OC(CCC(=O)O)c1ccccc1C 10.1021/jm9707131
10144334 130662 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 561 10 2 10 4.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL368211 130662 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 561 10 2 10 4.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL147510 208776 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
44385941 130674 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.6 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC(C)C2)nc1C(=O)O 10.1021/jm950592+
CHEMBL368286 130674 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.6 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC(C)C2)nc1C(=O)O 10.1021/jm950592+
31771 96964 None 37 Rat Binding pIC50 = 6.6 6.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 267 3 2 5 1.7 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00008a013
CHEMBL26630 96964 None 37 Rat Binding pIC50 = 6.6 6.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 267 3 2 5 1.7 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00008a013
11755275 200007 None 0 Rat Binding pIC50 = 6.6 6.6 - 1
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 489 9 1 7 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1cc(OC)ccc1OC 10.1016/S0960-894X(97)00319-3
CHEMBL59537 200007 None 0 Rat Binding pIC50 = 6.6 6.6 - 1
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 489 9 1 7 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1cc(OC)ccc1OC 10.1016/S0960-894X(97)00319-3
31771 96964 None 37 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 267 3 2 5 1.7 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00004a012
CHEMBL26630 96964 None 37 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 267 3 2 5 1.7 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00004a012
56657875 63323 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC 10.1021/jm970161m
CHEMBL1793925 63323 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC 10.1021/jm970161m
56681798 63326 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@@H](C)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)CNC(=O)[C@H](NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)[C@H](C)CC 10.1021/jm970161m
CHEMBL1793929 63326 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@@H](C)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)CNC(=O)[C@H](NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)[C@H](C)CC 10.1021/jm970161m
44327252 207531 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 495 7 1 8 3.1 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C3CC3)ccc2=O)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL94654 207531 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 495 7 1 8 3.1 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C3CC3)ccc2=O)cc1 10.1016/S0960-894X(96)00617-8
44266592 5373 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 431 4 1 7 4.5 COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10699 5373 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 431 4 1 7 4.5 COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL137754 208747 None 0 Pig Binding pIC50 = 6.6 6.6 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL436884 213688 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
44328019 155702 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1000 26 9 8 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL405178 155702 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1000 26 9 8 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44327348 161905 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1076 28 9 8 7.0 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL415238 161905 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1076 28 9 8 7.0 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10216862 196410 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 443 4 1 7 3.9 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n(Cc2ccc3c(c2)OCO3)c1=O 10.1016/S0960-894X(97)00319-3
CHEMBL56286 196410 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 443 4 1 7 3.9 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n(Cc2ccc3c(c2)OCO3)c1=O 10.1016/S0960-894X(97)00319-3
44327412 207579 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 5 1 8 3.0 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL94929 207579 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 5 1 8 3.0 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
44327114 207806 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 533 7 1 7 4.1 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)N2N=C(c3ccccc3)CCC2=O)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL96234 207806 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 533 7 1 7 4.1 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)N2N=C(c3ccccc3)CCC2=O)cc1 10.1016/S0960-894X(96)00617-8
10244529 59280 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 264 3 1 5 1.0 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(=O)[C@]2(O)CC1 10.1016/s0960-894x(00)00136-0
CHEMBL170450 59280 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 264 3 1 5 1.0 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(=O)[C@]2(O)CC1 10.1016/s0960-894x(00)00136-0
44279371 99922 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 466 3 2 3 5.5 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3cc(Cl)cc(Cl)c3)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL286214 99922 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 466 3 2 3 5.5 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3cc(Cl)cc(Cl)c3)cc21 10.1016/0960-894X(95)00230-Q
6426756 150707 None 40 Human Binding pIC50 = 4.6 4.6 - 0
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 537 9 3 10 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2nc(-c3ncccn3)nc(OCCO)c2Oc2ccccc2O)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL3956076 150707 None 40 Human Binding pIC50 = 4.6 4.6 - 0
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 537 9 3 10 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2nc(-c3ncccn3)nc(OCCO)c2Oc2ccccc2O)cc1 10.1016/j.bmcl.2016.06.014
23445254 207153 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 5 1 5 4.2 Cc1noc(NS(=O)(=O)c2sccc2Cc2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL92318 207153 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 5 1 5 4.2 Cc1noc(NS(=O)(=O)c2sccc2Cc2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
9810571 61384 None 0 Human Binding pIC50 = 6.6 6.6 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 731 18 2 13 5.0 CCCS(=O)(=O)NCCOc1nc(-c2cc(OC)c(OC)c(OC)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL176997 61384 None 0 Human Binding pIC50 = 6.6 6.6 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 731 18 2 13 5.0 CCCS(=O)(=O)NCCOc1nc(-c2cc(OC)c(OC)c(OC)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
127034756 136351 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 679 12 2 7 7.5 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3734829 136351 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 679 12 2 7 7.5 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
176 398 None 66 Human Binding pIC50 = 4.6 4.6 -7 31
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2157 398 None 66 Human Binding pIC50 = 4.6 4.6 -7 31
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2566 398 None 66 Human Binding pIC50 = 4.6 4.6 -7 31
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
CHEMBL633 398 None 66 Human Binding pIC50 = 4.6 4.6 -7 31
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
DB01118 398 None 66 Human Binding pIC50 = 4.6 4.6 -7 31
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
18617393 205275 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 308 5 1 4 3.2 CCc1ccc(CC)c(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
CHEMBL79066 205275 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 308 5 1 4 3.2 CCc1ccc(CC)c(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
44314647 205083 None 0 Pig Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCCCC1)C(=O)O 10.1021/jm9600914
CHEMBL77468 205083 None 0 Pig Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCCCC1)C(=O)O 10.1021/jm9600914
CHEMBL2304016 209470 None 0 Pig Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)[C@H]1NC(=O)[C@H](C(C)(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Cl)[nH]c3ccccc23)NC1=O 10.1021/jm9600914
10502226 101526 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 420 6 1 8 3.3 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1C 10.1021/jm9700068
CHEMBL298203 101526 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 420 6 1 8 3.3 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1C 10.1021/jm9700068
10715441 175924 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 390 6 1 6 3.9 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm9700068
CHEMBL45875 175924 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 390 6 1 6 3.9 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm9700068
10575755 179815 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 6 4.2 Cc1ccccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1021/jm9608366
CHEMBL47450 179815 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 6 4.2 Cc1ccccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1021/jm9608366
10168195 61385 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 631 11 2 13 5.0 C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL176999 61385 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 631 11 2 13 5.0 C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10744085 102868 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 503 9 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN(C)C)c2)cc1 10.1021/jm980504w
CHEMBL305777 102868 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 503 9 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN(C)C)c2)cc1 10.1021/jm980504w
10318748 99629 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 399 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCCC4=O)cccc23)c1C 10.1021/jm00008a013
CHEMBL284177 99629 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 399 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCCC4=O)cccc23)c1C 10.1021/jm00008a013
44316527 205478 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 280 3 1 4 2.7 Cc1ccc(C)c(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
CHEMBL80532 205478 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 280 3 1 4 2.7 Cc1ccc(C)c(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
44316831 205513 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 358 4 1 4 3.4 CCc1ccc(Br)c(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
CHEMBL80807 205513 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 358 4 1 4 3.4 CCc1ccc(Br)c(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
15296635 99553 None 0 Pig Binding pIC50 = 6.6 6.6 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 488 11 5 5 2.7 CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL283591 99553 None 0 Pig Binding pIC50 = 6.6 6.6 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 488 11 5 5 2.7 CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
23445224 203396 None 0 Human Binding pIC50 = 6.6 6.6 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 406 5 1 7 4.0 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/S0960-894X(97)00367-3
CHEMBL65488 203396 None 0 Human Binding pIC50 = 6.6 6.6 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 406 5 1 7 4.0 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/S0960-894X(97)00367-3
CHEMBL356864 211740 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
CHEMBL1791006 208910 None 0 Pig Binding pIC50 = 6.6 6.6 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H]([C@H](C)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44371396 49516 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 471 6 1 6 5.9 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3SC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL156532 49516 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 471 6 1 6 5.9 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3SC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
44371532 51473 None 1 Rat Binding pIC50 = 5.6 5.6 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 455 6 1 6 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cccc(OC)c3)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL158239 51473 None 1 Rat Binding pIC50 = 5.6 5.6 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 455 6 1 6 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cccc(OC)c3)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
44371571 119487 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 425 5 1 5 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL345380 119487 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 425 5 1 5 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
10473627 101887 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc12 10.1021/jm00008a013
CHEMBL30077 101887 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc12 10.1021/jm00008a013
18617395 205270 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 361 4 1 6 2.5 Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL79030 205270 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 361 4 1 6 2.5 Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1Br 10.1016/0960-894X(96)00441-6
10473627 101887 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc12 10.1021/jm00004a012
CHEMBL30077 101887 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc12 10.1021/jm00004a012
56681797 63322 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@H](C)CC 10.1021/jm970161m
CHEMBL1793924 63322 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@H](C)CC 10.1021/jm970161m
44213924 207494 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 567 7 1 7 4.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)N2N=C(c3ccc(Cl)cc3)CCC2=O)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL94426 207494 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 567 7 1 7 4.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)N2N=C(c3ccc(Cl)cc3)CCC2=O)cc1 10.1016/S0960-894X(96)00617-8
44266537 4326 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 507 8 1 6 6.4 COc1ccc(Cn2c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3cc(OCc4ccccc4)ccc32)cc1 10.1016/0960-894X(96)00170-9
CHEMBL10092 4326 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 507 8 1 6 6.4 COc1ccc(Cn2c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3cc(OCc4ccccc4)ccc32)cc1 10.1016/0960-894X(96)00170-9
44368414 121285 None 0 Pig Binding pIC50 = 4.6 4.6 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 459 9 1 5 4.2 COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccccc2)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
CHEMBL357978 121285 None 0 Pig Binding pIC50 = 4.6 4.6 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 459 9 1 5 4.2 COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccccc2)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
10470588 99990 None 2 Human Binding pIC50 = 4.6 4.6 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 309 6 2 5 2.9 CCCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00029a001
CHEMBL286682 99990 None 2 Human Binding pIC50 = 4.6 4.6 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 309 6 2 5 2.9 CCCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00029a001
10470588 99990 None 2 Rat Binding pIC50 = 4.6 4.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 309 6 2 5 2.9 CCCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00008a013
CHEMBL286682 99990 None 2 Rat Binding pIC50 = 4.6 4.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 309 6 2 5 2.9 CCCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00008a013
127035068 136371 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 633 10 2 7 7.7 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735036 136371 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 633 10 2 7 7.7 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10604119 11455 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 636 12 2 7 5.8 COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 10.1021/jm990171i
CHEMBL1180361 11455 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 636 12 2 7 5.8 COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 10.1021/jm990171i
CHEMBL123654 11455 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 636 12 2 7 5.8 COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 10.1021/jm990171i
23445241 102646 None 0 Human Binding pIC50 = 5.6 5.6 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 442 5 1 7 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccccc2)c1Br 10.1016/S0960-894X(97)00367-3
CHEMBL304406 102646 None 0 Human Binding pIC50 = 5.6 5.6 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 442 5 1 7 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccccc2)c1Br 10.1016/S0960-894X(97)00367-3
10554724 61763 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(C)CC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL177195 61763 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(C)CC2)nc1C(=O)O 10.1021/jm950592+
12146375 96847 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 322 3 1 5 2.6 Cc1noc(NS(=O)(=O)c2ccsc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL265290 96847 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 322 3 1 5 2.6 Cc1noc(NS(=O)(=O)c2ccsc2)c1Br 10.1016/S0960-894X(96)00496-9
9975719 96023 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc12 10.1021/jm00008a013
CHEMBL25977 96023 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc12 10.1021/jm00008a013
9975719 96023 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc12 10.1021/jm00004a012
CHEMBL25977 96023 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc12 10.1021/jm00004a012
127034919 136513 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 599 10 2 7 6.6 CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736310 136513 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 599 10 2 7 6.6 CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44384610 128469 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 743 16 2 14 4.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL366627 128469 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 743 16 2 14 4.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
137633653 156595 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 593 10 2 9 5.0 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4068786 156595 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 593 10 2 9 5.0 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
9868822 8589 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 459 6 1 7 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(N(C)C)cc2)cc1 10.1021/jm9606507
CHEMBL10948 8589 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 459 6 1 7 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(N(C)C)cc2)cc1 10.1021/jm9606507
CHEMBL2304013 209467 None 0 Pig Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)[C@H]1NC(=O)[C@H](C(C)(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC1=O 10.1021/jm9600914
443289 710 None 47 Rat Binding pIC50 = 7.6 7.6 -2 3
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL None None None None 10.1007/s00044-013-0542-3
997 710 None 47 Rat Binding pIC50 = 7.6 7.6 -2 3
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL None None None None 10.1007/s00044-013-0542-3
CHEMBL314691 710 None 47 Rat Binding pIC50 = 7.6 7.6 -2 3
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL None None None None 10.1007/s00044-013-0542-3
DB12054 710 None 47 Rat Binding pIC50 = 7.6 7.6 -2 3
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL None None None None 10.1007/s00044-013-0542-3
CHEMBL336033 211572 None 1 Rat Binding pIC50 = 7.6 7.6 - 0
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1016/j.bmc.2015.01.003
44295224 14629 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 532 9 1 9 4.6 COc1cc(C/C(C(=O)c2ccc3c(c2)CCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL1205077 14629 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 532 9 1 9 4.6 COc1cc(C/C(C(=O)c2ccc3c(c2)CCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL49675 14629 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 532 9 1 9 4.6 COc1cc(C/C(C(=O)c2ccc3c(c2)CCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
44294929 14792 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 460 8 1 7 4.7 COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1206731 14792 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 460 8 1 7 4.7 COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL301971 14792 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 460 8 1 7 4.7 COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
44320375 107143 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 506 8 1 7 5.3 COc1cc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)cc(OC)c1 10.1016/s0960-894x(00)00513-8
CHEMBL316187 107143 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 506 8 1 7 5.3 COc1cc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)cc(OC)c1 10.1016/s0960-894x(00)00513-8
10252787 99264 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 442 7 1 6 4.6 COc1cccc(Cn2nc(-c3ccccc3)c(Cc3ccc4c(c3)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL281865 99264 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 442 7 1 6 4.6 COc1cccc(Cn2nc(-c3ccccc3)c(Cc3ccc4c(c3)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00232-8
10839618 203572 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 517 10 1 8 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN(C)C)c2)cc1 10.1021/jm980504w
CHEMBL66762 203572 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 517 10 1 8 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN(C)C)c2)cc1 10.1021/jm980504w
17885919 206408 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 526 9 2 8 4.8 O=C(O)COc1ccccc1Cn1nc(-c2cccs2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
CHEMBL87801 206408 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 526 9 2 8 4.8 O=C(O)COc1ccccc1Cn1nc(-c2cccs2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
3795752 105200 None 1 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1C 10.1016/0960-894X(96)00441-6
CHEMBL311455 105200 None 1 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1C 10.1016/0960-894X(96)00441-6
44283453 138775 None 0 Pig Binding pIC50 = 6.6 6.6 - 0
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 641 12 4 7 4.8 CCCC[C@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)C(CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL37807 138775 None 0 Pig Binding pIC50 = 6.6 6.6 - 0
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 641 12 4 7 4.8 CCCC[C@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)C(CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
10721106 61404 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 9 4 5 4.3 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL177023 61404 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 9 4 5 4.3 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
10247887 98361 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 359 5 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(CN(C)C)cccc23)c1C 10.1021/jm00029a001
CHEMBL27525 98361 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 359 5 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(CN(C)C)cccc23)c1C 10.1021/jm00029a001
10247887 98361 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(CN(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL27525 98361 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(CN(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL86814 215890 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
CHEMBL408141 212701 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL86814 215890 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
CHEMBL344473 211704 None 0 Pig Binding pIC50 = 5.6 5.6 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](C)NC1=O 10.1021/jm00021a021
10444974 99597 None 24 Human Binding pIC50 = 4.6 4.6 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)on1 10.1021/jm00029a001
CHEMBL283941 99597 None 24 Human Binding pIC50 = 4.6 4.6 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)on1 10.1021/jm00029a001
10444974 99597 None 24 Rat Binding pIC50 = 4.6 4.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)on1 10.1021/jm00008a013
CHEMBL283941 99597 None 24 Rat Binding pIC50 = 4.6 4.6 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)on1 10.1021/jm00008a013
127035084 136381 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 707 13 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735151 136381 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 707 13 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44298395 100684 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 308 3 1 4 3.4 Cc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1C 10.1016/s0960-894x(00)00366-8
CHEMBL292355 100684 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 308 3 1 4 3.4 Cc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1C 10.1016/s0960-894x(00)00366-8
44298342 101755 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 283 3 2 5 2.1 Cc1snc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/s0960-894x(00)00366-8
CHEMBL299831 101755 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 283 3 2 5 2.1 Cc1snc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/s0960-894x(00)00366-8
18184179 129020 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 654 13 2 12 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL367017 129020 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 654 13 2 12 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
52950137 18432 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 559 10 3 8 3.8 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(=O)O)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271863 18432 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 559 10 3 8 3.8 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(=O)O)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
10760657 60021 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 355 7 1 6 4.0 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccoc1 10.1021/jm990378b
CHEMBL173565 60021 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 355 7 1 6 4.0 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccoc1 10.1021/jm990378b
10717279 97045 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 425 9 1 5 4.8 CCCCCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL266996 97045 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 425 9 1 5 4.8 CCCCCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
18948954 167904 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 360 4 2 5 3.5 Cc1noc(NS(=O)(=O)c2cccc3c(C(C)(C)O)cccc23)c1C 10.1021/jm00008a013
CHEMBL431300 167904 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 360 4 2 5 3.5 Cc1noc(NS(=O)(=O)c2cccc3c(C(C)(C)O)cccc23)c1C 10.1021/jm00008a013
11783885 100885 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 382 7 1 5 4.6 CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm031041j
CHEMBL293702 100885 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 382 7 1 5 4.6 CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm031041j
18617340 105401 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 422 4 1 4 3.9 CCc1ccc(Br)c(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
CHEMBL311742 105401 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 422 4 1 4 3.9 CCc1ccc(Br)c(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
11783885 100885 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 382 7 1 5 4.6 CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
CHEMBL293702 100885 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 382 7 1 5 4.6 CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
155511294 169567 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n([C@@H](C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/j.bmcl.2016.06.014
CHEMBL4435789 169567 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n([C@@H](C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/j.bmcl.2016.06.014
44293805 101112 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 545 10 2 10 3.5 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCc1nn[nH]n1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL295140 101112 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 545 10 2 10 3.5 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCc1nn[nH]n1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10693679 207371 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 425 10 2 5 4.7 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C(N)=O 10.1021/jm9707131
CHEMBL93749 207371 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 425 10 2 5 4.7 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C(N)=O 10.1021/jm9707131
9848132 207575 None 0 Rat Binding pIC50 = 7.5 7.5 1 2
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 483 6 1 8 2.8 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL94918 207575 None 0 Rat Binding pIC50 = 7.5 7.5 1 2
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 483 6 1 8 2.8 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
44387111 166180 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 548 10 5 5 4.2 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
CHEMBL426413 166180 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 548 10 5 5 4.2 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
10506505 128667 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 535 11 4 5 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H](CC(=O)NC2CCCCC2)CC(C)C)nc1C(=O)O 10.1021/jm9505932
CHEMBL366805 128667 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 535 11 4 5 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H](CC(=O)NC2CCCCC2)CC(C)C)nc1C(=O)O 10.1021/jm9505932
CHEMBL137716 208746 None 0 Pig Binding pIC50 = 7.5 7.5 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None COC(=O)n1cc(C[C@@H]2NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H]3CCCN3C(=O)[C@H](CC(=O)O)NC2=O)c2ccccc21 10.1021/jm00021a021
137655525 158989 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 525 7 3 9 3.5 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(O)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4096346 158989 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 525 7 3 9 3.5 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(O)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
10383850 99767 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 1 5 3.6 CCc1c(C)noc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm00008a013
CHEMBL285122 99767 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 1 5 3.6 CCc1c(C)noc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm00008a013
10882352 202981 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 340 4 1 5 3.4 CCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
CHEMBL63099 202981 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 340 4 1 5 3.4 CCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
44279383 99992 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 398 3 2 3 4.2 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccccc3)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL286687 99992 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 398 3 2 3 4.2 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccccc3)cc21 10.1016/0960-894X(95)00230-Q
23445221 203093 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 470 5 1 7 4.4 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00367-3
CHEMBL63937 203093 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 470 5 1 7 4.4 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00367-3
44327237 207927 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 511 8 1 8 3.5 CCCc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL96847 207927 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 511 8 1 8 3.5 CCCc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
15453172 204983 None 4 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL76623 204983 None 4 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c1Br 10.1016/0960-894X(96)00441-6
44213923 108279 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 563 8 1 8 4.1 COc1ccc(C2=NN(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)C(=O)CC2)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL319743 108279 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 563 8 1 8 4.1 COc1ccc(C2=NN(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)C(=O)CC2)cc1 10.1016/S0960-894X(96)00617-8
10530457 62110 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 538 9 5 6 4.0 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)NO 10.1021/jm950592+
CHEMBL177602 62110 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 538 9 5 6 4.0 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)NO 10.1021/jm950592+
10168939 131366 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 695 11 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL368860 131366 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 695 11 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL170600 208843 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL None None None CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)N[C@H](CC(=O)O)C(=O)O 10.1016/0960-894X(95)00144-I
CHEMBL1201469 14505 None 0 Human Binding pIC50 = 5.5 5.5 -1 4
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL None None None None nan
23445227 120823 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 472 6 1 8 3.9 Cc1noc(NS(=O)(=O)c2ccsc2COc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
CHEMBL355800 120823 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 472 6 1 8 3.9 Cc1noc(NS(=O)(=O)c2ccsc2COc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
10789525 61768 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2cccc(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL177221 61768 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2cccc(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
10789524 5190 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OC)c2)cc1 10.1021/jm9606507
CHEMBL10607 5190 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OC)c2)cc1 10.1021/jm9606507
10896413 100605 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.4 COc1ccc(CCOC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL291841 100605 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.4 COc1ccc(CCOC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
11762291 100634 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccccc1C1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL292041 100634 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccccc1C1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
11059249 102616 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 440 10 1 6 5.3 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCCCC)cc21 10.1021/jm010382z
CHEMBL304202 102616 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 440 10 1 6 5.3 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCCCC)cc21 10.1021/jm010382z
11144468 203459 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 430 5 1 5 5.2 CC(C)Oc1ccc2c(c1)C(c1ccccc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL65925 203459 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 430 5 1 5 5.2 CC(C)Oc1ccc2c(c1)C(c1ccccc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10184817 9572 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 488 14 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)CCC 10.1021/jm980217s
CHEMBL112417 9572 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 488 14 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)CCC 10.1021/jm980217s
44314904 103145 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 585 12 5 5 3.6 CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
CHEMBL307936 103145 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 585 12 5 5 3.6 CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
155564169 175331 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 545 11 1 12 2.0 COc1ccc(Cl)c(Oc2c(NS(C)(=O)=O)ncnc2OCCOc2ncc(S(C)(=O)=O)cn2)c1 10.1016/j.bmcl.2016.06.014
CHEMBL4574034 175331 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 545 11 1 12 2.0 COc1ccc(Cl)c(Oc2c(NS(C)(=O)=O)ncnc2OCCOc2ncc(S(C)(=O)=O)cn2)c1 10.1016/j.bmcl.2016.06.014
71455062 81677 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 669 14 1 12 5.0 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C(F)(F)F)cn1 10.1021/jm3009103
CHEMBL2163705 81677 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 669 14 1 12 5.0 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C(F)(F)F)cn1 10.1021/jm3009103
44295005 10218 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 538 10 1 9 4.8 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)c(F)c1 10.1016/s0960-894x(98)00301-1
CHEMBL1160205 10218 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 538 10 1 9 4.8 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)c(F)c1 10.1016/s0960-894x(98)00301-1
10226215 101430 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 8 3.8 Cc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
CHEMBL297473 101430 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 8 3.8 Cc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
44291255 173457 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 8 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2C)OCO3)c1Cl 10.1021/jm9700068
CHEMBL45296 173457 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 8 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2C)OCO3)c1Cl 10.1021/jm9700068
CHEMBL414165 213113 None 0 Pig Binding pIC50 = 8.5 8.5 - 0
Inhibitory effect against porcine ET-A receptorInhibitory effect against porcine ET-A receptor
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](c2cccs2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44311345 204215 None 0 Human Binding pIC50 = 8.5 8.5 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 663 13 3 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CCNCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70895 204215 None 0 Human Binding pIC50 = 8.5 8.5 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 663 13 3 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CCNCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL414165 213113 None 0 Pig Binding pIC50 = 8.5 8.5 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](c2cccs2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
8260 531 None 54 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at ETA receptor (unknown origin) in presence of ET1Antagonist activity at ETA receptor (unknown origin) in presence of ET1
ChEMBL 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 10.1016/j.bmcl.2016.06.014
9912992 531 None 54 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at ETA receptor (unknown origin) in presence of ET1Antagonist activity at ETA receptor (unknown origin) in presence of ET1
ChEMBL 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 10.1016/j.bmcl.2016.06.014
CHEMBL3989834 531 None 54 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at ETA receptor (unknown origin) in presence of ET1Antagonist activity at ETA receptor (unknown origin) in presence of ET1
ChEMBL 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 10.1016/j.bmcl.2016.06.014
44458597 98789 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 535 7 3 8 2.3 Cn1cc(C(C(=O)NS(=O)(=O)c2ccccc2C(=O)O)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL278349 98789 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 535 7 3 8 2.3 Cn1cc(C(C(=O)NS(=O)(=O)c2ccccc2C(=O)O)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
11017071 9953 None 0 Pig Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 547 9 1 9 4.3 Cc1ccc(-c2c(NS(=O)(=O)c3cccs3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL114683 9953 None 0 Pig Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 547 9 1 9 4.3 Cc1ccc(-c2c(NS(=O)(=O)c3cccs3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
10994373 162452 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 5 1 7 5.0 CC(C)Oc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL416675 162452 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 5 1 7 5.0 CC(C)Oc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10122033 81675 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 631 15 1 13 4.0 COc1cnc(OCCOc2nc(-c3ncccn3)nc(NS(=O)(=O)CCc3ccccc3)c2Oc2ccccc2OC)nc1 10.1021/jm3009103
CHEMBL2163703 81675 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 631 15 1 13 4.0 COc1cnc(OCCOc2nc(-c3ncccn3)nc(NS(=O)(=O)CCc3ccccc3)c2Oc2ccccc2OC)nc1 10.1021/jm3009103
44334145 4650 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 460 6 1 6 4.6 COc1ccc([C@@H]2c3nc(N(C)C(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL103090 4650 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 460 6 1 6 4.6 COc1ccc([C@@H]2c3nc(N(C)C(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
44352026 117483 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 548 11 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C(F)(F)F)cc1 10.1021/jm010237l
CHEMBL339969 117483 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 548 11 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C(F)(F)F)cc1 10.1021/jm010237l
44339840 9286 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 486 13 1 5 5.1 C/C=C(\C)CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL110904 9286 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 486 13 1 5 5.1 C/C=C(\C)CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
10577829 9665 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 518 13 1 7 3.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OCCCO1 10.1021/jm980217s
CHEMBL112877 9665 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 518 13 1 7 3.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OCCCO1 10.1021/jm980217s
73669821 117625 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Displacement of PD156707 from rat ETA receptor after 1 hr by Lowry methodDisplacement of PD156707 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 448 10 1 6 5.2 CC(=O)c1ccc(OCc2ccc3c(c2)OCO3)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
CHEMBL3400988 117625 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Displacement of PD156707 from rat ETA receptor after 1 hr by Lowry methodDisplacement of PD156707 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 448 10 1 6 5.2 CC(=O)c1ccc(OCc2ccc3c(c2)OCO3)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
21041307 174967 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 482 10 2 9 2.6 CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4566095 174967 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 482 10 2 9 2.6 CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
10274552 73511 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 434 6 1 8 3.6 Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C)OCO2 10.1021/jm9700068
CHEMBL20168 73511 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 434 6 1 8 3.6 Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C)OCO2 10.1021/jm9700068
10274552 73511 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 434 6 1 8 3.6 Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C)OCO2 10.1021/jm000349x
CHEMBL20168 73511 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 434 6 1 8 3.6 Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C)OCO2 10.1021/jm000349x
16004692 2452 None 91 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
4809 2452 None 91 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
7352 2452 None 91 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
CHEMBL2103873 2452 None 91 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
DB08932 2452 None 91 Human Binding pIC50 = 8.5 8.5 - 0
Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
10070 449 None 47 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1016/j.bmcl.2016.06.014
25099191 449 None 47 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1016/j.bmcl.2016.06.014
CHEMBL2165326 449 None 47 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1016/j.bmcl.2016.06.014
DB15059 449 None 47 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1016/j.bmcl.2016.06.014
10070 449 None 47 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1021/jm3009103
25099191 449 None 47 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1021/jm3009103
CHEMBL2165326 449 None 47 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1021/jm3009103
DB15059 449 None 47 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1021/jm3009103
71455065 81697 None 1 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 679 14 2 11 4.8 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ccncc2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163724 81697 None 1 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 679 14 2 11 4.8 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ccncc2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
17869373 14632 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 460 8 1 7 4.7 COc1ccc(C(=O)/C(Cc2cccc(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1205094 14632 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 460 8 1 7 4.7 COc1ccc(C(=O)/C(Cc2cccc(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL51890 14632 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 460 8 1 7 4.7 COc1ccc(C(=O)/C(Cc2cccc(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
44295106 14740 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 472 7 1 7 4.6 COc1ccc(C(=O)/C(Cc2ccc3c(c2)CCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1206319 14740 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 472 7 1 7 4.6 COc1ccc(C(=O)/C(Cc2ccc3c(c2)CCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL262000 14740 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 472 7 1 7 4.6 COc1ccc(C(=O)/C(Cc2ccc3c(c2)CCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
17869279 14877 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 460 8 1 7 4.7 COc1ccc(C(=O)/C(Cc2ccccc2OC)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1207701 14877 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 460 8 1 7 4.7 COc1ccc(C(=O)/C(Cc2ccccc2OC)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL431160 14877 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 460 8 1 7 4.7 COc1ccc(C(=O)/C(Cc2ccccc2OC)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
44320171 106955 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 504 6 1 5 6.4 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC12CC3CC(CC(C3)C1)C2 10.1016/s0960-894x(00)00513-8
CHEMBL314974 106955 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 504 6 1 5 6.4 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC12CC3CC(CC(C3)C1)C2 10.1016/s0960-894x(00)00513-8
11135910 10209 None 0 Pig Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 624 10 1 10 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL116002 10209 None 0 Pig Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 624 10 1 10 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
10205245 72207 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 466 5 2 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2C#N)OCO3)c1Cl 10.1021/jm9608366
CHEMBL19808 72207 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 466 5 2 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2C#N)OCO3)c1Cl 10.1021/jm9608366
44291575 179433 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 466 5 2 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2C#N)OCO3)c1Cl 10.1021/jm9700068
CHEMBL47404 179433 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 466 5 2 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2C#N)OCO3)c1Cl 10.1021/jm9700068
10205245 72207 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 466 5 2 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2C#N)OCO3)c1Cl 10.1021/jm000349x
CHEMBL19808 72207 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 466 5 2 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2C#N)OCO3)c1Cl 10.1021/jm000349x
CHEMBL133257 208713 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibitory effect against Human ET-A receptorInhibitory effect against Human ET-A receptor
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C2CCCC2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
11634755 62305 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 480 7 1 7 4.9 COc1cc(/C(C(=O)O)=C(\CC2CCCCC2)C(=O)c2ccc3c(c2)OCCO3)cc2c1OCO2 10.1021/jm031041j
CHEMBL177886 62305 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 480 7 1 7 4.9 COc1cc(/C(C(=O)O)=C(\CC2CCCCC2)C(=O)c2ccc3c(c2)OCCO3)cc2c1OCO2 10.1021/jm031041j
44304492 96558 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL262993 96558 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
18738878 194830 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 547 8 2 7 4.2 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL539420 194830 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 547 8 2 7 4.2 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
9958846 170175 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 537 13 1 10 3.7 COCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)CCc2ccccc2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
CHEMBL4444693 170175 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 537 13 1 10 3.7 COCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)CCc2ccccc2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
71455140 82006 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 598 12 2 8 4.7 CC(C)c1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
CHEMBL2165336 82006 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 598 12 2 8 4.7 CC(C)c1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
11123269 206298 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 452 6 1 5 5.8 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
CHEMBL87070 206298 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 452 6 1 5 5.8 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
10697520 12115 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 530 10 2 6 4.9 CCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
CHEMBL1184086 12115 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 530 10 2 6 4.9 CCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
CHEMBL331936 12115 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 530 10 2 6 4.9 CCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
10530156 9555 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 526 14 1 6 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(OC)cc2OC)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL112347 9555 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 526 14 1 6 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(OC)cc2OC)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
44295206 14791 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 580 12 1 11 4.7 COc1cc(C/C(C(=O)c2cc(OC)c(OC)c(OC)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL1206728 14791 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 580 12 1 11 4.7 COc1cc(C/C(C(=O)c2cc(OC)c(OC)c(OC)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL301577 14791 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 580 12 1 11 4.7 COc1cc(C/C(C(=O)c2cc(OC)c(OC)c(OC)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
11059349 203507 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 6 1 6 4.8 CCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm031041j
CHEMBL66264 203507 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 6 1 6 4.8 CCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm031041j
15453178 104751 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 348 4 1 4 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Cl 10.1016/0960-894X(96)00441-6
CHEMBL310739 104751 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 348 4 1 4 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Cl 10.1016/0960-894X(96)00441-6
11059349 203507 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 446 6 1 6 4.8 CCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL66264 203507 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 446 6 1 6 4.8 CCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
44314610 102854 None 0 Pig Binding pIC50 = 8.4 8.4 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 671 12 6 5 3.9 CC(C)CC(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)N[C@H](Cc1c(Br)[nH]c2ccccc12)C(=O)NC(Cc1c[nH]cn1)C(=O)O 10.1021/jm9600914
CHEMBL305650 102854 None 0 Pig Binding pIC50 = 8.4 8.4 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 671 12 6 5 3.9 CC(C)CC(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)N[C@H](Cc1c(Br)[nH]c2ccccc12)C(=O)NC(Cc1c[nH]cn1)C(=O)O 10.1021/jm9600914
44314619 204684 None 0 Pig Binding pIC50 = 8.4 8.4 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 631 12 5 4 4.5 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
CHEMBL73925 204684 None 0 Pig Binding pIC50 = 8.4 8.4 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 631 12 5 4 4.5 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
71451529 81691 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 632 14 2 12 3.4 CCCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
CHEMBL2163719 81691 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 632 14 2 12 3.4 CCCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
10504920 163108 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 480 6 2 9 3.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CC#N)OCO3)c1Cl 10.1021/jm9608366
CHEMBL417719 163108 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 480 6 2 9 3.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CC#N)OCO3)c1Cl 10.1021/jm9608366
CHEMBL284250 210858 None 0 Pig Binding pIC50 = 8.4 8.4 - 0
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1016/0960-894X(95)00237-N
10579100 166339 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 578 10 2 6 5.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(Cc2ccccc2)c2ccccc2)cc1 10.1021/jm031041j
CHEMBL122614 166339 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 578 10 2 6 5.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(Cc2ccccc2)c2ccccc2)cc1 10.1021/jm031041j
CHEMBL427303 166339 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 578 10 2 6 5.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(Cc2ccccc2)c2ccccc2)cc1 10.1021/jm031041j
10579100 166339 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 578 10 2 6 5.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(Cc2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL122614 166339 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 578 10 2 6 5.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(Cc2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL427303 166339 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 578 10 2 6 5.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(Cc2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
10695363 5252 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 462 6 1 7 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(SC)cc2)cc1 10.1021/jm9606507
CHEMBL10636 5252 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 462 6 1 7 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(SC)cc2)cc1 10.1021/jm9606507
73669820 117626 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 462 10 1 7 5.5 CC(=O)c1ccc(OCc2ccc3nsnc3c2)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
CHEMBL3400989 117626 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 462 10 1 7 5.5 CC(=O)c1ccc(OCc2ccc3nsnc3c2)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
44380952 27486 None 0 Pig Binding pIC50 = 8.4 8.4 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 679 10 1 9 7.3 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(-c3cccs3)nc2OCCOc2ncc(Br)cn2)cc1 10.1016/s0960-894x(01)00682-5
CHEMBL136871 27486 None 0 Pig Binding pIC50 = 8.4 8.4 - 0
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 679 10 1 9 7.3 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(-c3cccs3)nc2OCCOc2ncc(Br)cn2)cc1 10.1016/s0960-894x(01)00682-5
44291897 101291 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 482 7 2 9 3.6 COc1cc(C#N)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 10.1021/jm9608366
CHEMBL296456 101291 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 482 7 2 9 3.6 COc1cc(C#N)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 10.1021/jm9608366
9956918 170881 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 482 7 2 9 3.6 COc1cc(C#N)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1OC 10.1021/jm9700068
CHEMBL44544 170881 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 482 7 2 9 3.6 COc1cc(C#N)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1OC 10.1021/jm9700068
44279172 108650 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 532 10 2 6 4.6 CCCCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccccc1 10.1016/S0960-894X(97)00228-X
CHEMBL32075 108650 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 532 10 2 6 4.6 CCCCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccccc1 10.1016/S0960-894X(97)00228-X
10022121 101827 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 371 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCC4)cccc23)c1C 10.1021/jm00008a013
CHEMBL30032 101827 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 371 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCC4)cccc23)c1C 10.1021/jm00008a013
9957225 5263 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 490 8 0 8 4.7 COc1ccc(C2OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
CHEMBL10644 5263 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 490 8 0 8 4.7 COc1ccc(C2OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
18738880 168172 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 561 8 2 7 4.5 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)NC)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL433221 168172 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 561 8 2 7 4.5 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)NC)cc21 10.1016/s0960-894x(01)00660-6
10738157 59250 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2cccnc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL170348 59250 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2cccnc2)ccc1C#N)C(=O)O 10.1021/jm990378b
10714797 120715 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 380 7 1 6 4.1 Cc1ccccc1C(Oc1cc(OCc2cncs2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL354740 120715 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 380 7 1 6 4.1 Cc1ccccc1C(Oc1cc(OCc2cncs2)ccc1C#N)C(=O)O 10.1021/jm990378b
10622380 101453 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 426 7 1 7 3.9 COc1cccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 10.1021/jm9700068
CHEMBL297679 101453 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 426 7 1 7 3.9 COc1cccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 10.1021/jm9700068
CHEMBL2369736 209662 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N(C)[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
CHEMBL65559 215859 None 0 Pig Binding pIC50 = 7.5 7.5 - 0
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
9850566 4192 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 551 8 1 8 6.1 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 10.1016/0960-894X(96)00170-9
CHEMBL10016 4192 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 551 8 1 8 6.1 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 10.1016/0960-894X(96)00170-9
CHEMBL342615 211673 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibitory effect against Human Endothelin A receptorInhibitory effect against Human Endothelin A receptor
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44311527 204121 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 675 12 2 11 7.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2cccs2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70365 204121 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 675 12 2 11 7.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2cccs2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL148751 208782 None 0 Human Binding pIC50 = 7.5 7.5 - 0
The inhibitory constant was evaluated against Endothelin A receptorThe inhibitory constant was evaluated against Endothelin A receptor
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
10836474 61778 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 432 9 1 5 4.7 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc(OC)cc2OC)cc1 10.1021/jm031041j
CHEMBL177287 61778 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 432 9 1 5 4.7 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc(OC)cc2OC)cc1 10.1021/jm031041j
10788853 6108 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc(OC)cc3OC)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL10808 6108 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc(OC)cc3OC)=C2Cc2ccccc2)cc1 10.1021/jm9606507
10717504 98511 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 6 0 6 4.5 COc1ccc(C2(OC)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL276173 98511 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 6 0 6 4.5 COc1ccc(C2(OC)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
10717504 98511 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 430 6 0 6 4.5 COc1ccc(C2(OC)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL276173 98511 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 430 6 0 6 4.5 COc1ccc(C2(OC)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1016/S0960-894X(97)00002-4
10522605 206776 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 361 6 1 4 5.0 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1C#N)CO 10.1021/jm970847e
CHEMBL90191 206776 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 361 6 1 4 5.0 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1C#N)CO 10.1021/jm970847e
10595639 207069 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 375 6 1 4 5.1 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1C#N)C(=O)O 10.1021/jm970847e
CHEMBL91810 207069 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 375 6 1 4 5.1 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1C#N)C(=O)O 10.1021/jm970847e
10697377 61085 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 523 10 4 6 4.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL176513 61085 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 523 10 4 6 4.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL3349461 211407 None 0 Pig Binding pIC50 = 5.5 5.5 - 0
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00089a028
18617366 167834 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 394 3 1 4 3.3 Cc1noc(NS(=O)(=O)c2ccc(Br)cc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL430822 167834 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 394 3 1 4 3.3 Cc1noc(NS(=O)(=O)c2ccc(Br)cc2)c1Br 10.1016/0960-894X(96)00441-6
44314864 103034 None 0 Pig Binding pIC50 = 5.5 5.5 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 566 11 5 5 3.4 CCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
CHEMBL307077 103034 None 0 Pig Binding pIC50 = 5.5 5.5 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 566 11 5 5 3.4 CCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
10788691 206761 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 428 6 1 3 6.0 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1Br)C(=O)O 10.1021/jm970847e
CHEMBL90094 206761 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 428 6 1 3 6.0 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1Br)C(=O)O 10.1021/jm970847e
127035544 136358 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 721 14 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3734870 136358 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 721 14 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10549875 59798 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2cccc3c2OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL172691 59798 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2cccc3c2OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL2367550 209582 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
10506524 61178 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 9 4 5 4.2 CNC(=O)c1nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)oc1C 10.1021/jm950592+
CHEMBL176565 61178 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 9 4 5 4.2 CNC(=O)c1nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)oc1C 10.1021/jm950592+
10743900 127805 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 497 11 4 5 4.0 CCN(CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C)o1 10.1021/jm950592+
CHEMBL366387 127805 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 497 11 4 5 4.0 CCN(CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C)o1 10.1021/jm950592+
CHEMBL432683 213632 None 0 Pig Binding pIC50 = 5.5 5.5 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44368396 44590 None 0 Pig Binding pIC50 = 4.5 4.5 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 506 8 2 5 4.9 COc1ccc(C(=O)N(Cc2cc3c(cc2Cl)OCO3)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
CHEMBL152017 44590 None 0 Pig Binding pIC50 = 4.5 4.5 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 506 8 2 5 4.9 COc1ccc(C(=O)N(Cc2cc3c(cc2Cl)OCO3)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
95285 97271 None 37 Rat Binding pIC50 = 4.5 4.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 256 3 2 5 1.7 O=S(=O)(Nc1nccs1)c1ccc(O)cc1 10.1021/jm00008a013
CHEMBL26894 97271 None 37 Rat Binding pIC50 = 4.5 4.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 256 3 2 5 1.7 O=S(=O)(Nc1nccs1)c1ccc(O)cc1 10.1021/jm00008a013
CHEMBL1791272 208915 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)[C@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00152-J
10027408 97143 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 463 10 2 5 6.1 Cc1noc(NS(=O)(=O)c2cccc3c(NCCCCCc4ccccc4)cccc23)c1C 10.1021/jm00008a013
CHEMBL26786 97143 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 463 10 2 5 6.1 Cc1noc(NS(=O)(=O)c2cccc3c(NCCCCCc4ccccc4)cccc23)c1C 10.1021/jm00008a013
23445410 106142 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 4 1 5 4.6 Cc1ccccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL313551 106142 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 4 1 5 4.6 Cc1ccccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
23445379 130097 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 456 6 1 6 4.8 Cc1ccc(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
CHEMBL367776 130097 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 456 6 1 6 4.8 Cc1ccc(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
44459299 89605 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 520 7 3 6 4.4 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2c[nH]c3cc(C(=O)O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL23752 89605 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 520 7 3 6 4.4 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2c[nH]c3cc(C(=O)O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
44293754 101963 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 531 9 2 10 3.5 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(c1nn[nH]n1)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL301371 101963 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 531 9 2 10 3.5 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(c1nn[nH]n1)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10552051 101169 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 463 6 2 9 3.3 CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C)OCO2 10.1021/jm9608366
CHEMBL295583 101169 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 463 6 2 9 3.3 CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C)OCO2 10.1021/jm9608366
18704821 99819 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 419 5 1 5 3.7 COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1-c1ccccc1 10.1016/S0960-894X(97)00228-X
CHEMBL285512 99819 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 419 5 1 5 3.7 COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1-c1ccccc1 10.1016/S0960-894X(97)00228-X
44279367 99752 None 0 Pig Binding pIC50 = 6.5 6.5 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 485 11 5 4 2.0 CC(C)C[C@H](NC(=O)N1CCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL285031 99752 None 0 Pig Binding pIC50 = 6.5 6.5 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 485 11 5 4 2.0 CC(C)C[C@H](NC(=O)N1CCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
10575356 9707 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 446 8 1 4 3.7 CCCN(C)C(=O)CN1C[C@H](c2ccc(F)c(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL113184 9707 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 446 8 1 4 3.7 CCCN(C)C(=O)CN1C[C@H](c2ccc(F)c(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10551532 110582 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 450 8 1 4 3.9 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL325444 110582 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 450 8 1 4 3.9 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
127035219 136356 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3734849 136356 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44293719 96654 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 581 12 2 10 3.9 CCOc1ccc2c(c1)[C@@H](c1cc(OC)c(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL263723 96654 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 581 12 2 10 3.9 CCOc1ccc2c(c1)[C@@H](c1cc(OC)c(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
11800505 62233 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 536 11 3 6 5.1 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H](CC(=O)NC2CCCCC2)CC(C)C)nc1C(=O)O 10.1021/jm9505932
CHEMBL177839 62233 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 536 11 3 6 5.1 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H](CC(=O)NC2CCCCC2)CC(C)C)nc1C(=O)O 10.1021/jm9505932
10570511 207107 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 360 6 1 4 4.2 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(N)=O)c1ccccc1 10.1021/jm970847e
CHEMBL92092 207107 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 360 6 1 4 4.2 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(N)=O)c1ccccc1 10.1021/jm970847e
44276577 106855 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 459 7 1 7 4.1 COc1cccc(Cn2[nH]c(-c3ccc([N+](=O)[O-])cc3)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144850 106855 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 459 7 1 7 4.1 COc1cccc(Cn2[nH]c(-c3ccc([N+](=O)[O-])cc3)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
10357554 97562 None 1 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1021/jm00004a012
CHEMBL27065 97562 None 1 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1021/jm00004a012
44368539 45172 None 0 Pig Binding pIC50 = 4.5 4.5 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 475 9 2 6 3.9 COc1cccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccc(O)cc2)C(=O)O)c1 10.1016/s0960-894x(01)00009-9
CHEMBL152552 45172 None 0 Pig Binding pIC50 = 4.5 4.5 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 475 9 2 6 3.9 COc1cccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccc(O)cc2)C(=O)O)c1 10.1016/s0960-894x(01)00009-9
10476286 96426 None 0 Rat Binding pIC50 = 4.5 4.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 403 6 1 7 3.2 CCOC(=O)c1c(C)noc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm00008a013
CHEMBL26206 96426 None 0 Rat Binding pIC50 = 4.5 4.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 403 6 1 7 3.2 CCOC(=O)c1c(C)noc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm00008a013
127037496 136401 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 613 12 2 7 6.9 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 10.1039/C4MD00499J
CHEMBL3735311 136401 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 613 12 2 7 6.9 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 10.1039/C4MD00499J
22998508 206930 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 4 1 5 4.6 Cc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
CHEMBL91073 206930 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 4 1 5 4.6 Cc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
10020445 101366 None 0 Rat Binding pIC50 = 4.5 4.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3cccc(N(C)C)c3c2)c1C 10.1021/jm00008a013
CHEMBL29705 101366 None 0 Rat Binding pIC50 = 4.5 4.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3cccc(N(C)C)c3c2)c1C 10.1021/jm00008a013
10020445 101366 None 0 Rat Binding pIC50 = 4.5 4.5 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3cccc(N(C)C)c3c2)c1C 10.1021/jm00004a012
CHEMBL29705 101366 None 0 Rat Binding pIC50 = 4.5 4.5 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3cccc(N(C)C)c3c2)c1C 10.1021/jm00004a012
10645779 97167 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 419 4 1 4 4.2 Cc1cc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL268116 97167 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 419 4 1 4 4.2 Cc1cc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
10832243 203501 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 358 5 1 6 2.5 COc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nn1 10.1021/jm9604585
CHEMBL6624 203501 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 358 5 1 6 2.5 COc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nn1 10.1021/jm9604585
10692649 203104 None 1 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 404 4 1 3 4.5 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)cc3)cccc12 10.1021/jm9604585
CHEMBL6400 203104 None 1 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 404 4 1 3 4.5 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)cc3)cccc12 10.1021/jm9604585
CHEMBL293874 210890 None 0 Pig Binding pIC50 = 7.5 7.5 - 0
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)CN(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00089a028
18738879 90231 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 548 8 2 7 4.8 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)O)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL23833 90231 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 548 8 2 7 4.8 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)O)cc21 10.1016/s0960-894x(01)00660-6
18738879 90231 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 548 8 2 7 4.8 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)O)cc21 10.1007/s00044-004-0021-y
CHEMBL23833 90231 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 548 8 2 7 4.8 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)O)cc21 10.1007/s00044-004-0021-y
10548486 174114 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 391 5 2 6 3.7 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm9608366
CHEMBL45456 174114 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 391 5 2 6 3.7 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm9608366
44327661 164588 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 483 5 1 8 2.7 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL421563 164588 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 483 5 1 8 2.7 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
44327226 207913 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 7 1 8 3.1 CCc1cc(C)nn(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c1=O 10.1016/S0960-894X(96)00617-8
CHEMBL96762 207913 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 7 1 8 3.1 CCc1cc(C)nn(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c1=O 10.1016/S0960-894X(96)00617-8
CHEMBL132542 208701 None 0 Pig Binding pIC50 = 7.5 7.5 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)CN(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10647372 207115 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 8 1 6 3.1 CCN(CC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9212 207115 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 8 1 6 3.1 CCN(CC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL329609 211316 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)[C@@H](C)CC 10.1021/jm00015a003
10665805 98176 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 354 4 1 6 3.0 CCC1=C(c2ccc3c(c2)OCO3)C(=O)OC1(O)c1ccc(OC)cc1 10.1021/jm9606507
CHEMBL273951 98176 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 354 4 1 6 3.0 CCC1=C(c2ccc3c(c2)OCO3)C(=O)OC1(O)c1ccc(OC)cc1 10.1021/jm9606507
44298381 195902 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 476 9 2 7 4.9 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCO)c1 10.1016/s0960-894x(00)00366-8
CHEMBL55909 195902 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 476 9 2 7 4.9 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCO)c1 10.1016/s0960-894x(00)00366-8
44279408 104659 None 0 Pig Binding pIC50 = 5.5 5.5 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 521 13 6 4 2.7 CC(C)C[C@H](NC(=O)NCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31051 104659 None 0 Pig Binding pIC50 = 5.5 5.5 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 521 13 6 4 2.7 CC(C)C[C@H](NC(=O)NCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44327868 111442 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 906 24 9 8 3.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC12CC3CC(CC(C3)C1)C2)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL327523 111442 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 906 24 9 8 3.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC12CC3CC(CC(C3)C1)C2)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL2369713 209653 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00152-J
CHEMBL1793934 208930 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm970161m
44327399 161541 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 539 7 1 8 4.2 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)N2N=C(c3cccs3)CCC2=O)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL412865 161541 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 539 7 1 8 4.2 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)N2N=C(c3cccs3)CCC2=O)cc1 10.1016/S0960-894X(96)00617-8
44327734 208098 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 561 8 1 9 3.9 COc1ccc(-c2ccc(=O)n(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)n2)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL97851 208098 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 561 8 1 9 3.9 COc1ccc(-c2ccc(=O)n(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)n2)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL282340 210849 None 0 Pig Binding pIC50 = 4.5 4.5 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membrane was determinedBinding affinity against ETA receptor in porcine aortic smooth muscle membrane was determined
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](N)C(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(=O)O)C(=O)O 10.1016/0960-894X(95)00221-E
44284506 167957 None 0 Pig Binding pIC50 = 4.5 4.5 - 0
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 596 14 4 4 4.6 CC(C)C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)N(C)C(=O)[C@@H](CC(C)C)NC(=O)Cc1ccccc1Cl)C(=O)O 10.1021/jm00087a001
CHEMBL431699 167957 None 0 Pig Binding pIC50 = 4.5 4.5 - 0
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 596 14 4 4 4.6 CC(C)C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)N(C)C(=O)[C@@H](CC(C)C)NC(=O)Cc1ccccc1Cl)C(=O)O 10.1021/jm00087a001
10555806 12120 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 616 12 2 7 6.0 CC(C)OCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 10.1021/jm990171i
CHEMBL1184095 12120 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 616 12 2 7 6.0 CC(C)OCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 10.1021/jm990171i
CHEMBL332289 12120 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 616 12 2 7 6.0 CC(C)OCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 10.1021/jm990171i
23445505 203555 None 0 Human Binding pIC50 = 5.5 5.5 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 412 5 1 7 4.0 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1016/S0960-894X(97)00367-3
CHEMBL66641 203555 None 0 Human Binding pIC50 = 5.5 5.5 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 412 5 1 7 4.0 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1016/S0960-894X(97)00367-3
44314676 102922 None 0 Pig Binding pIC50 = 7.5 7.5 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 589 12 5 4 4.6 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
CHEMBL306171 102922 None 0 Pig Binding pIC50 = 7.5 7.5 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 589 12 5 4 4.6 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
10577388 15577 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cc(C)ccc2C)cc1 10.1021/jm990170q
CHEMBL122111 15577 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cc(C)ccc2C)cc1 10.1021/jm990170q
10625270 113373 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C)cccc2C)cc1 10.1021/jm990170q
CHEMBL331767 113373 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C)cccc2C)cc1 10.1021/jm990170q
70240112 171601 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 626 10 2 11 5.0 CC#CCOc1nc(-c2ccnc(-c3nnn[nH]3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
CHEMBL4465332 171601 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 626 10 2 11 5.0 CC#CCOc1nc(-c2ccnc(-c3nnn[nH]3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
44310016 203837 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 489 6 1 9 4.8 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4nsnc4c3)c2cc1OC 10.1016/s0960-894x(97)10151-2
CHEMBL68557 203837 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 489 6 1 9 4.8 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4nsnc4c3)c2cc1OC 10.1016/s0960-894x(97)10151-2
44386143 130690 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 571 9 3 6 5.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCc3ccccc32)nc1C(=O)O 10.1021/jm950592+
CHEMBL368360 130690 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 571 9 3 6 5.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCc3ccccc32)nc1C(=O)O 10.1021/jm950592+
44310016 203837 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 489 6 1 9 4.8 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4nsnc4c3)c2cc1OC 10.1021/jm0300429
CHEMBL68557 203837 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 489 6 1 9 4.8 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4nsnc4c3)c2cc1OC 10.1021/jm0300429
CHEMBL422285 213283 None 0 Pig Binding pIC50 = 7.5 7.5 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CCC[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44279312 107323 None 0 Pig Binding pIC50 = 6.5 6.5 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 565 12 6 4 3.5 CC(C)C[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31746 107323 None 0 Pig Binding pIC50 = 6.5 6.5 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 565 12 6 4 3.5 CC(C)C[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44305079 102089 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL302189 102089 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
44293813 184107 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 581 12 2 10 3.9 CCOc1ccc2c(c1)[C@H](c1cc(OC)c(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL48261 184107 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 581 12 2 10 3.9 CCOc1ccc2c(c1)[C@H](c1cc(OC)c(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
44270523 48614 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 724 14 1 9 8.0 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL15573 48614 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 724 14 1 9 8.0 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL404763 212530 None 0 Pig Binding pIC50 = 6.5 6.5 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)C(C)(C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44293716 101414 None 0 Human Binding pIC50 = 5.5 5.5 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 433 6 1 6 4.0 COc1ccc([C@@H]2c3cc(OC)ccc3[C@@H](c3ccc4c(c3)OCO4)N2CC(=O)O)cc1 10.1016/s0960-894x(01)00273-6
CHEMBL297353 101414 None 0 Human Binding pIC50 = 5.5 5.5 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 433 6 1 6 4.0 COc1ccc([C@@H]2c3cc(OC)ccc3[C@@H](c3ccc4c(c3)OCO4)N2CC(=O)O)cc1 10.1016/s0960-894x(01)00273-6
18936171 196504 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 489 7 1 8 4.2 COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2c(OC)c(OC)ccc21 10.1016/S0960-894X(97)00319-3
CHEMBL56348 196504 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 489 7 1 8 4.2 COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2c(OC)c(OC)ccc21 10.1016/S0960-894X(97)00319-3
44332546 107211 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 491 5 0 7 5.7 O=C(OCc1ccc2c(c1)OCO2)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL316648 107211 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 491 5 0 7 5.7 O=C(OCc1ccc2c(c1)OCO2)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
44322947 206699 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 428 5 1 6 4.3 COc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
CHEMBL89689 206699 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 428 5 1 6 4.3 COc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
10067069 99484 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 360 4 1 6 3.0 COC(=O)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL283195 99484 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 360 4 1 6 3.0 COC(=O)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
44385805 61294 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 532 10 1 10 4.1 C#CCOc1nc(-c2cnccn2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL176698 61294 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 532 10 1 10 4.1 C#CCOc1nc(-c2cnccn2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10230375 129647 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 534 9 2 11 2.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL367317 129647 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 534 9 2 11 2.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
44384557 131388 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 504 9 1 10 3.3 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL369003 131388 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 504 9 1 10 3.3 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
23445547 112340 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2cc(-c3ccccc3)cs2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL329375 112340 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2cc(-c3ccccc3)cs2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL303204 210916 None 0 Pig Binding pIC50 = 7.5 7.5 - 0
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00089a028
22467219 85346 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 492 6 2 7 3.3 Cc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CO)ccc23)cc1 10.1007/s00044-004-0021-y
CHEMBL2261362 85346 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 492 6 2 7 3.3 Cc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CO)ccc23)cc1 10.1007/s00044-004-0021-y
44320461 106347 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 514 6 1 5 6.6 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00513-8
CHEMBL313920 106347 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 514 6 1 5 6.6 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00513-8
10457385 112686 None 0 Rat Binding pIC50 = 7.5 7.5 - 1
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL330424 112686 None 0 Rat Binding pIC50 = 7.5 7.5 - 1
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL263537 210571 None 0 Pig Binding pIC50 = 7.5 7.5 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10670664 207315 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 438 8 2 6 2.6 C=CCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9342 207315 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 438 8 2 6 2.6 C=CCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10792636 168513 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 10 2 6 5.4 CCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 10.1021/jm990170q
CHEMBL435385 168513 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 10 2 6 5.4 CCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 10.1021/jm990170q
44327423 207539 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 483 6 1 8 2.8 Cc1cc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)nc1C 10.1016/S0960-894X(96)00617-8
CHEMBL94720 207539 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 483 6 1 8 2.8 Cc1cc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)nc1C 10.1016/S0960-894X(96)00617-8
9998563 96843 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)c2ccccc12 10.1021/jm00008a013
CHEMBL26527 96843 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)c2ccccc12 10.1021/jm00008a013
10895198 100952 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 9 1 6 5.0 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2cccc(OCCC)c21 10.1021/jm010382z
CHEMBL294123 100952 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 9 1 6 5.0 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2cccc(OCCC)c21 10.1021/jm010382z
44298612 195523 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 281 4 2 5 1.9 CCc1c(NS(=O)(=O)c2ccc(N)cc2)noc1C 10.1016/s0960-894x(00)00366-8
CHEMBL55405 195523 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 281 4 2 5 1.9 CCc1c(NS(=O)(=O)c2ccc(N)cc2)noc1C 10.1016/s0960-894x(00)00366-8
9998563 96843 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)c2ccccc12 10.1021/jm00004a012
CHEMBL26527 96843 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)c2ccccc12 10.1021/jm00004a012
44332638 4374 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 477 6 0 6 6.0 COc1ccc(COC(=O)C(c2ccc3c(c2)OCO3)c2c3ccccc3nc3ccccc23)cc1 10.1016/S0960-894X(96)00551-3
CHEMBL101239 4374 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 477 6 0 6 6.0 COc1ccc(COC(=O)C(c2ccc3c(c2)OCO3)c2c3ccccc3nc3ccccc23)cc1 10.1016/S0960-894X(96)00551-3
137643691 158256 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 569 10 2 7 5.5 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4088634 158256 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 569 10 2 7 5.5 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
23445538 60069 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 456 6 1 6 4.8 Cc1ccc(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
CHEMBL173805 60069 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 456 6 1 6 4.8 Cc1ccc(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
23445272 127748 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 440 6 1 5 4.7 Cc1ccc(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
CHEMBL366364 127748 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 440 6 1 5 4.7 Cc1ccc(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
10615322 203416 None 0 Human Binding pIC50 = 5.5 5.5 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 316 4 1 7 1.9 COC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C 10.1016/S0960-894X(97)00367-3
CHEMBL65639 203416 None 0 Human Binding pIC50 = 5.5 5.5 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 316 4 1 7 1.9 COC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C 10.1016/S0960-894X(97)00367-3
11762081 203317 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 7 1 5 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
CHEMBL64851 203317 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 7 1 5 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
CHEMBL307324 210977 None 0 Pig Binding pIC50 = 7.5 7.5 - 0
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL None None None CC(C)C[C@H]1C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CC(=O)O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N1C 10.1021/jm00089a028
CHEMBL319719 211219 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10503067 8168 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 436 5 1 6 4.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCCCC2)cc1 10.1021/jm9606507
CHEMBL10919 8168 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 436 5 1 6 4.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCCCC2)cc1 10.1021/jm9606507
11762081 203317 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 446 7 1 5 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL64851 203317 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 446 7 1 5 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
155519245 170342 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 592 10 2 10 4.2 COc1ccc(Cl)c(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(N3CCOCC3)nc2OCCO)c1 10.1016/j.bmcl.2016.06.014
CHEMBL4447261 170342 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 592 10 2 10 4.2 COc1ccc(Cl)c(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(N3CCOCC3)nc2OCCO)c1 10.1016/j.bmcl.2016.06.014
22467240 99185 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 558 7 2 9 3.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(-c4nn[nH]n4)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL281378 99185 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 558 7 2 9 3.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(-c4nn[nH]n4)ccc23)cc1 10.1016/s0960-894x(01)00660-6
10305334 129045 None 0 Human Binding pIC50 = 7.5 7.5 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 680 12 2 11 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL367036 129045 None 0 Human Binding pIC50 = 7.5 7.5 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 680 12 2 11 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL138120 208749 None 0 Pig Binding pIC50 = 7.5 7.5 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@@H]1C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CC(=O)O)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](C(C)C)C(=O)N1C 10.1021/jm00021a021
11133491 102167 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 416 3 1 6 4.2 O=C(O)C1=C(c2ccc3c(c2)OCO3)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
CHEMBL302659 102167 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 416 3 1 6 4.2 O=C(O)C1=C(c2ccc3c(c2)OCO3)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
10950843 202950 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1cccc(OC)c1)O2 10.1021/jm010382z
CHEMBL62951 202950 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1cccc(OC)c1)O2 10.1021/jm010382z
44279370 107204 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 426 4 2 3 4.7 CCc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 10.1016/0960-894X(95)00230-Q
CHEMBL31662 107204 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 426 4 2 3 4.7 CCc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 10.1016/0960-894X(95)00230-Q
CHEMBL1790451 208887 None 0 Pig Binding pIC50 = 6.5 6.5 - 0
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL None None None CC(=O)N[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C)[C@H](C)O)C1c2ccccc2CCc2ccccc21 10.1016/0960-894X(95)00349-X
10790376 166907 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 466 6 1 6 3.3 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N2CCCCC2)cc1 10.1021/jm9505369
CHEMBL428644 166907 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 466 6 1 6 3.3 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N2CCCCC2)cc1 10.1021/jm9505369
44266655 5041 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 445 5 1 7 4.5 COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10523 5041 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 445 5 1 7 4.5 COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
44371420 50908 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cccc(OC)c3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL157763 50908 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cccc(OC)c3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
10425958 99951 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc(N)c3ccccc23)c1C 10.1021/jm00008a013
CHEMBL286406 99951 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc(N)c3ccccc23)c1C 10.1021/jm00008a013
CHEMBL438194 213751 None 14 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
44327881 161673 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1044 26 9 8 6.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL413179 161673 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1044 26 9 8 6.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44298613 195525 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 287 3 2 5 2.0 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1Cl 10.1016/s0960-894x(00)00366-8
CHEMBL55406 195525 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 287 3 2 5 2.0 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1Cl 10.1016/s0960-894x(00)00366-8
CHEMBL438768 213794 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
44277387 106848 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 450 7 2 6 3.0 O=C(O)COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144800 106848 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 450 7 2 6 3.0 O=C(O)COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
10425958 99951 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc(N)c3ccccc23)c1C 10.1021/jm00004a012
CHEMBL286406 99951 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc(N)c3ccccc23)c1C 10.1021/jm00004a012
44266645 207755 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 417 5 1 6 4.7 COc1ccc(-n2c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3cc(OC)ccc32)cc1 10.1016/0960-894X(96)00170-9
CHEMBL9588 207755 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 417 5 1 6 4.7 COc1ccc(-n2c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3cc(OC)ccc32)cc1 10.1016/0960-894X(96)00170-9
127034918 136456 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 599 11 2 7 6.6 CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 10.1039/C4MD00499J
CHEMBL3735797 136456 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 599 11 2 7 6.6 CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 10.1039/C4MD00499J
CHEMBL263025 210556 None 0 Pig Binding pIC50 = 4.5 4.5 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)CNC(=O)[C@@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44386523 132580 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 621 10 4 6 5.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2c(F)c(F)c(F)c(F)c2F)nc1C(=O)O 10.1021/jm950592+
CHEMBL369874 132580 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 621 10 4 6 5.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2c(F)c(F)c(F)c(F)c2F)nc1C(=O)O 10.1021/jm950592+
CHEMBL421190 213267 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL2304009 209463 None 0 Pig Binding pIC50 = 7.4 7.4 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O 10.1021/jm9600914
CHEMBL87243 215891 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00070a001
44327347 96761 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1102 26 9 8 7.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1c2ccccc2CCc2ccccc21)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL264579 96761 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1102 26 9 8 7.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1c2ccccc2CCc2ccccc21)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44368516 44809 None 0 Pig Binding pIC50 = 4.4 4.4 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 451 11 2 6 4.1 COc1ccc(CN(Cc2cc(OC)cc(OC)c2)C(Cc2ccc(O)cc2)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
CHEMBL152203 44809 None 0 Pig Binding pIC50 = 4.4 4.4 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 451 11 2 6 4.1 COc1ccc(CN(Cc2cc(OC)cc(OC)c2)C(Cc2ccc(O)cc2)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
10816835 61383 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 567 11 4 5 5.7 CCCc1sc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL176992 61383 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 567 11 4 5 5.7 CCCc1sc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
137652304 157224 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 544 10 3 8 3.7 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCCN)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4076290 157224 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 544 10 3 8 3.7 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCCN)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
22998446 106630 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL314320 106630 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)c1Br 10.1016/S0960-894X(96)00496-9
443289 710 None 47 Human Binding pIC50 = 7.4 7.4 2 3
Antagonist activity at Homo sapiens (human) ETA receptorAntagonist activity at Homo sapiens (human) ETA receptor
ChEMBL None None None None 10.1007/s00044-013-0542-3
997 710 None 47 Human Binding pIC50 = 7.4 7.4 2 3
Antagonist activity at Homo sapiens (human) ETA receptorAntagonist activity at Homo sapiens (human) ETA receptor
ChEMBL None None None None 10.1007/s00044-013-0542-3
CHEMBL314691 710 None 47 Human Binding pIC50 = 7.4 7.4 2 3
Antagonist activity at Homo sapiens (human) ETA receptorAntagonist activity at Homo sapiens (human) ETA receptor
ChEMBL None None None None 10.1007/s00044-013-0542-3
DB12054 710 None 47 Human Binding pIC50 = 7.4 7.4 2 3
Antagonist activity at Homo sapiens (human) ETA receptorAntagonist activity at Homo sapiens (human) ETA receptor
ChEMBL None None None None 10.1007/s00044-013-0542-3
11798762 206621 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 475 9 1 7 3.1 CCCS(=O)(=O)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL8911 206621 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 475 9 1 7 3.1 CCCS(=O)(=O)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10768346 131541 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 522 10 5 5 4.0 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL369202 131541 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 522 10 5 5 4.0 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC2)nc1C(=O)O 10.1021/jm950592+
24997097 18471 None 3 Human Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 501 7 3 7 4.0 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(O)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1272137 18471 None 3 Human Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 501 7 3 7 4.0 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(O)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
44309445 102697 None 4 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 370 4 1 5 3.4 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc4c(c3)OCO4)cccc12 10.1016/s0960-894x(97)10151-2
CHEMBL304761 102697 None 4 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 370 4 1 5 3.4 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc4c(c3)OCO4)cccc12 10.1016/s0960-894x(97)10151-2
10816963 113327 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 574 12 2 7 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC)cc1 10.1021/jm990170q
CHEMBL331625 113327 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 574 12 2 7 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC)cc1 10.1021/jm990170q
CHEMBL289687 210873 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
10602726 165784 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 549 10 4 5 5.1 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C2CC2)o1 10.1021/jm950591h
CHEMBL424764 165784 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 549 10 4 5 5.1 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C2CC2)o1 10.1021/jm950591h
44332623 4764 None 1 Human Binding pIC50 = 4.4 4.4 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 320 3 1 4 2.9 Cc1cc(C(C(N)=O)c2ccc3c(c2)OCO3)c2ccccc2n1 10.1016/S0960-894X(96)00551-3
CHEMBL103886 4764 None 1 Human Binding pIC50 = 4.4 4.4 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 320 3 1 4 2.9 Cc1cc(C(C(N)=O)c2ccc3c(c2)OCO3)c2ccccc2n1 10.1016/S0960-894X(96)00551-3
137655285 158975 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 568 10 3 10 3.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCCN)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4096211 158975 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 568 10 3 10 3.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCCN)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
44177614 129649 None 0 Human Binding pIC50 = 6.4 6.4 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 547 10 1 9 5.4 C=CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL367339 129649 None 0 Human Binding pIC50 = 6.4 6.4 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 547 10 1 9 5.4 C=CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
22467229 98955 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 519 7 2 7 4.1 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CN)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL279703 98955 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 519 7 2 7 4.1 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CN)ccc23)cc1 10.1016/s0960-894x(01)00660-6
44385008 131359 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 574 10 2 9 4.9 C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL368829 131359 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 574 10 2 9 4.9 C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
19010493 98354 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 543 11 1 7 6.5 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL275179 98354 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 543 11 1 7 6.5 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
42630532 18397 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 541 10 2 7 4.9 C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1271479 18397 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 541 10 2 7 4.9 C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
42630532 18397 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 541 10 2 7 4.9 C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271479 18397 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 541 10 2 7 4.9 C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
24997097 18471 None 3 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 501 7 3 7 4.0 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(O)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1272137 18471 None 3 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 501 7 3 7 4.0 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(O)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
10173807 50880 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 455 6 1 6 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL157742 50880 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 455 6 1 6 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
18995990 99354 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 507 7 1 9 5.0 COc1cccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc4c(cc23)OCO4)c1 10.1016/0960-894X(96)00232-6
CHEMBL282426 99354 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 507 7 1 9 5.0 COc1cccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc4c(cc23)OCO4)c1 10.1016/0960-894X(96)00232-6
10160887 100146 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 447 5 1 7 5.0 O=C(O)c1c(Sc2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00232-6
CHEMBL28779 100146 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 447 5 1 7 5.0 O=C(O)c1c(Sc2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00232-6
CHEMBL411797 212955 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44298277 194997 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 474 9 1 7 5.1 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCC=O)c1 10.1016/s0960-894x(00)00366-8
CHEMBL54773 194997 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 474 9 1 7 5.1 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCC=O)c1 10.1016/s0960-894x(00)00366-8
10288713 102041 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 473 7 1 7 4.6 CCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
CHEMBL301840 102041 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 473 7 1 7 4.6 CCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
CHEMBL62514 215842 None 0 Pig Binding pIC50 = 6.4 6.4 - 0
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL None None None CC(=O)N[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C)C1c2ccccc2CCc2ccccc21 10.1016/0960-894X(95)00349-X
10383832 168177 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc2c1 10.1021/jm00008a013
CHEMBL433234 168177 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc2c1 10.1021/jm00008a013
10540843 85837 None 9 Human Binding pIC50 = 5.4 5.4 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 282 4 1 3 4.0 Cc1c(C(=O)O)oc2cccc(OCc3ccccc3)c12 10.1007/s00044-013-0542-3
CHEMBL2296889 85837 None 9 Human Binding pIC50 = 5.4 5.4 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 282 4 1 3 4.0 Cc1c(C(=O)O)oc2cccc(OCc3ccccc3)c12 10.1007/s00044-013-0542-3
CHEMBL408141 212701 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
18617407 204978 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL76576 204978 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1C 10.1016/0960-894X(96)00441-6
44276886 106831 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 410 4 1 4 4.2 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccccc1Cl 10.1016/s0960-894x(00)00232-8
CHEMBL3144600 106831 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 410 4 1 4 4.2 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccccc1Cl 10.1016/s0960-894x(00)00232-8
44277368 106843 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 480 8 2 7 3.0 COc1ccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c(OCC(=O)O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144733 106843 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 480 8 2 7 3.0 COc1ccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c(OCC(=O)O)c1 10.1016/s0960-894x(00)00232-8
10070783 97054 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL267094 97054 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
10383832 168177 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc2c1 10.1021/jm00004a012
CHEMBL433234 168177 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc2c1 10.1021/jm00004a012
44368482 44682 None 0 Pig Binding pIC50 = 4.4 4.4 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 523 8 2 7 4.2 O=C(O)C(Cc1ccc(O)cc1)N(Cc1cc2c(cc1Cl)OCO2)C(=O)/C=C/c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00009-9
CHEMBL152091 44682 None 0 Pig Binding pIC50 = 4.4 4.4 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 523 8 2 7 4.2 O=C(O)C(Cc1ccc(O)cc1)N(Cc1cc2c(cc1Cl)OCO2)C(=O)/C=C/c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00009-9
4550514 97203 None 6 Rat Binding pIC50 = 4.4 4.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 386 5 3 5 3.7 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)c1C 10.1021/jm00008a013
CHEMBL26842 97203 None 6 Rat Binding pIC50 = 4.4 4.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 386 5 3 5 3.7 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)c1C 10.1021/jm00008a013
127035083 136354 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3734835 136354 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
76320429 85839 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL 324 4 1 6 3.6 Cc1c(C(=O)O)oc2cccc(OCc3ccc4nonc4c3)c12 10.1007/s00044-013-0542-3
CHEMBL2296900 85839 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL 324 4 1 6 3.6 Cc1c(C(=O)O)oc2cccc(OCc3ccc4nonc4c3)c12 10.1007/s00044-013-0542-3
10875450 9822 None 0 Pig Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 565 11 1 10 4.9 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2nccc(C)n2)c1 10.1021/jm0102304
CHEMBL113927 9822 None 0 Pig Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 565 11 1 10 4.9 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2nccc(C)n2)c1 10.1021/jm0102304
18704814 100120 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 475 7 1 5 4.9 COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL287581 100120 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 475 7 1 5 4.9 COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
44279173 107261 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 476 6 2 6 3.1 CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccccc1 10.1016/S0960-894X(97)00228-X
CHEMBL31696 107261 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 476 6 2 6 3.1 CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccccc1 10.1016/S0960-894X(97)00228-X
44279237 110530 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 462 6 2 6 2.8 COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccccc1 10.1016/S0960-894X(97)00228-X
CHEMBL32512 110530 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 462 6 2 6 2.8 COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccccc1 10.1016/S0960-894X(97)00228-X
44309996 203757 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 483 5 1 8 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccc4nsnc4c3)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(97)10151-2
CHEMBL67971 203757 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 483 5 1 8 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccc4nsnc4c3)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(97)10151-2
CHEMBL342913 211693 None 0 Pig Binding pIC50 = 6.4 6.4 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None COC(=O)C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C1=O 10.1021/jm00021a021
44279300 106531 None 0 Pig Binding pIC50 = 5.4 5.4 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membrane was determinedBinding affinity against ETA receptor in porcine aortic smooth muscle membrane was determined
ChEMBL 472 13 5 4 2.4 CC(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31405 106531 None 0 Pig Binding pIC50 = 5.4 5.4 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membrane was determinedBinding affinity against ETA receptor in porcine aortic smooth muscle membrane was determined
ChEMBL 472 13 5 4 2.4 CC(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44279350 168174 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 428 4 2 4 4.2 COc1cccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)c1 10.1016/0960-894X(95)00230-Q
CHEMBL433229 168174 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 428 4 2 4 4.2 COc1cccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)c1 10.1016/0960-894X(95)00230-Q
10390467 97126 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 481 6 1 5 6.4 Cc1noc(NS(=O)(=O)c2cccc3c(N=C(c4ccccc4)c4ccccc4)cccc23)c1C 10.1021/jm00008a013
CHEMBL26776 97126 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 481 6 1 5 6.4 Cc1noc(NS(=O)(=O)c2cccc3c(N=C(c4ccccc4)c4ccccc4)cccc23)c1C 10.1021/jm00008a013
10373814 14897 None 0 Pig Binding pIC50 = 4.4 4.4 - 0
Displacement of [125]ET1 from ETA receptor in pig thoracic aortaDisplacement of [125]ET1 from ETA receptor in pig thoracic aorta
ChEMBL 1016 2 6 12 7.0 O=C1NCCc2ccc(c(Br)c2)Oc2cc(ccc2O)CCNC(=O)/C(=N/O)Cc2cc(Br)c(OS(=O)(=O)O)c(c2)Oc2c(Br)cc(cc2Br)C/C1=N\O 10.1021/np50099a026
CHEMBL1207961 14897 None 0 Pig Binding pIC50 = 4.4 4.4 - 0
Displacement of [125]ET1 from ETA receptor in pig thoracic aortaDisplacement of [125]ET1 from ETA receptor in pig thoracic aorta
ChEMBL 1016 2 6 12 7.0 O=C1NCCc2ccc(c(Br)c2)Oc2cc(ccc2O)CCNC(=O)/C(=N/O)Cc2cc(Br)c(OS(=O)(=O)O)c(c2)Oc2c(Br)cc(cc2Br)C/C1=N\O 10.1021/np50099a026
CHEMBL465400 14897 None 0 Pig Binding pIC50 = 4.4 4.4 - 0
Displacement of [125]ET1 from ETA receptor in pig thoracic aortaDisplacement of [125]ET1 from ETA receptor in pig thoracic aorta
ChEMBL 1016 2 6 12 7.0 O=C1NCCc2ccc(c(Br)c2)Oc2cc(ccc2O)CCNC(=O)/C(=N/O)Cc2cc(Br)c(OS(=O)(=O)O)c(c2)Oc2c(Br)cc(cc2Br)C/C1=N\O 10.1021/np50099a026
10793886 59816 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 615 11 4 5 6.3 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)s1 10.1021/jm950591h
CHEMBL172760 59816 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 615 11 4 5 6.3 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)s1 10.1021/jm950591h
10625083 206644 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 10 1 5 5.3 CCCCN(CCCC)C(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL8925 206644 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 10 1 5 5.3 CCCCN(CCCC)C(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10833400 161892 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 376 4 1 5 3.5 Cc1cc(Cl)nnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL415106 161892 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 376 4 1 5 3.5 Cc1cc(Cl)nnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
11793650 97322 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 372 6 1 6 2.9 CCOc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nn1 10.1021/jm9604585
CHEMBL269237 97322 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 372 6 1 6 2.9 CCOc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nn1 10.1021/jm9604585
25211074 18483 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in membranes by radioligand assayAntagonist activity at ETA receptor (unknown origin) expressed in membranes by radioligand assay
ChEMBL 543 10 2 7 5.1 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1272244 18483 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in membranes by radioligand assayAntagonist activity at ETA receptor (unknown origin) expressed in membranes by radioligand assay
ChEMBL 543 10 2 7 5.1 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL405599 212566 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10767505 5298 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 494 6 1 8 3.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(S(C)(=O)=O)cc2)cc1 10.1021/jm9606507
CHEMBL10661 5298 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 494 6 1 8 3.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(S(C)(=O)=O)cc2)cc1 10.1021/jm9606507
10673715 9549 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 528 14 1 5 5.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCCC(F)(F)F 10.1021/jm980217s
CHEMBL112314 9549 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 528 14 1 5 5.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCCC(F)(F)F 10.1021/jm980217s
10650210 102784 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 545 9 1 9 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN3CCOCC3)c2)cc1 10.1021/jm980504w
CHEMBL305267 102784 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 545 9 1 9 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN3CCOCC3)c2)cc1 10.1021/jm980504w
10361993 99564 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 373 5 1 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C(C)C)cccc23)c1C 10.1021/jm00004a012
CHEMBL283652 99564 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 373 5 1 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C(C)C)cccc23)c1C 10.1021/jm00004a012
44304492 96558 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
CHEMBL262993 96558 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
CHEMBL133257 208713 None 0 Pig Binding pIC50 = 8.4 8.4 - 0
Inhibitory effect against porcine ET-A receptorInhibitory effect against porcine ET-A receptor
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C2CCCC2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44311232 204105 None 0 Human Binding pIC50 = 8.4 8.4 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 658 13 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70293 204105 None 0 Human Binding pIC50 = 8.4 8.4 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 658 13 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44311233 204107 None 0 Human Binding pIC50 = 8.4 8.4 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 630 12 2 13 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70303 204107 None 0 Human Binding pIC50 = 8.4 8.4 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 630 12 2 13 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL133257 208713 None 0 Pig Binding pIC50 = 8.4 8.4 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C2CCCC2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10961277 101015 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 446 5 2 6 4.9 CC(C)Oc1ccc2c(c1)C(c1ccc(O)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL294496 101015 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 446 5 2 6 4.9 CC(C)Oc1ccc2c(c1)C(c1ccc(O)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10391968 188432 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL50232 188432 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
25211074 18483 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 543 10 2 7 5.1 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1272244 18483 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 543 10 2 7 5.1 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
11058717 202814 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 8 1 6 4.6 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCC)cc21 10.1021/jm010382z
CHEMBL62348 202814 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 8 1 6 4.6 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCC)cc21 10.1021/jm010382z
9807200 85343 None 0 Human Binding pIC50 = 8.4 8.4 346 2
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261359 85343 None 0 Human Binding pIC50 = 8.4 8.4 346 2
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
71451528 81687 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 631 14 1 12 4.3 CCCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
CHEMBL2163715 81687 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 631 14 1 12 4.3 CCCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
21041249 81660 None 1 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 648 11 1 8 4.7 CN(Cc1ccccc1)S(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
CHEMBL2163688 81660 None 1 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 648 11 1 8 4.7 CN(Cc1ccccc1)S(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
71451525 81669 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 629 12 1 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1021/jm3009103
CHEMBL2163697 81669 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 629 12 1 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1021/jm3009103
71451528 81687 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 631 14 1 12 4.3 CCCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
CHEMBL2163715 81687 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 631 14 1 12 4.3 CCCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
11059576 203291 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL64726 203291 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
21041266 82010 None 1 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 584 10 2 8 3.3 O=S(=O)(Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1)NC1CC1 10.1021/jm3009103
CHEMBL2165340 82010 None 1 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 584 10 2 8 3.3 O=S(=O)(Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1)NC1CC1 10.1021/jm3009103
10625633 207137 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 514 12 1 8 2.4 COCCN(CCOC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9223 207137 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 514 12 1 8 2.4 COCCN(CCOC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10697636 167818 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 536 13 1 7 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1SCCS1 10.1021/jm980217s
CHEMBL430683 167818 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 536 13 1 7 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1SCCS1 10.1021/jm980217s
10279940 101349 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 527 8 2 10 3.6 CC(=O)OCCc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
CHEMBL296927 101349 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 527 8 2 10 3.6 CC(=O)OCCc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
44333578 4603 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 417 5 1 5 4.4 CCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL102773 4603 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 417 5 1 5 4.4 CCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
44439111 97174 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 979 31 2 15 7.0 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOc2ccc(CC(=O)N(C)Cc3cc(-c4ncco4)ccc3-c3ccccc3S(=O)(=O)Nc3ccno3)cc2)cc1 10.1016/j.bmcl.2006.10.009
CHEMBL268201 97174 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 979 31 2 15 7.0 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOc2ccc(CC(=O)N(C)Cc3cc(-c4ncco4)ccc3-c3ccccc3S(=O)(=O)Nc3ccno3)cc2)cc1 10.1016/j.bmcl.2006.10.009
44295032 14788 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 520 10 1 9 4.7 COc1cccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)c1 10.1016/s0960-894x(98)00301-1
CHEMBL1206717 14788 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 520 10 1 9 4.7 COc1cccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)c1 10.1016/s0960-894x(98)00301-1
CHEMBL299572 14788 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 520 10 1 9 4.7 COc1cccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)c1 10.1016/s0960-894x(98)00301-1
9959298 60513 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 552 10 2 7 5.4 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)N(C)C2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL175698 60513 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 552 10 2 7 5.4 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)N(C)C2CCCCC2)nc1C(=O)O 10.1021/jm9505932
10625530 207038 None 3 Rat Binding pIC50 = 8.3 8.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm031041j
CHEMBL9162 207038 None 3 Rat Binding pIC50 = 8.3 8.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm031041j
10625530 207038 None 3 Rat Binding pIC50 = 8.3 8.3 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9162 207038 None 3 Rat Binding pIC50 = 8.3 8.3 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10917653 203375 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 468 11 1 6 6.1 CCCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL65292 203375 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 468 11 1 6 6.1 CCCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
104865 705 None 99 Human Binding pIC50 = 8.3 8.3 1 4
Binding affinity to human ETA receptorBinding affinity to human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.ejmech.2016.06.006
3494 705 None 99 Human Binding pIC50 = 8.3 8.3 1 4
Binding affinity to human ETA receptorBinding affinity to human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.ejmech.2016.06.006
392 705 None 99 Human Binding pIC50 = 8.3 8.3 1 4
Binding affinity to human ETA receptorBinding affinity to human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.ejmech.2016.06.006
CHEMBL957 705 None 99 Human Binding pIC50 = 8.3 8.3 1 4
Binding affinity to human ETA receptorBinding affinity to human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.ejmech.2016.06.006
DB00559 705 None 99 Human Binding pIC50 = 8.3 8.3 1 4
Binding affinity to human ETA receptorBinding affinity to human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.ejmech.2016.06.006
104865 705 None 99 Rat Binding pIC50 = 8.3 8.3 -1 4
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2015.01.003
3494 705 None 99 Rat Binding pIC50 = 8.3 8.3 -1 4
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2015.01.003
392 705 None 99 Rat Binding pIC50 = 8.3 8.3 -1 4
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2015.01.003
CHEMBL957 705 None 99 Rat Binding pIC50 = 8.3 8.3 -1 4
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2015.01.003
DB00559 705 None 99 Rat Binding pIC50 = 8.3 8.3 -1 4
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2015.01.003
17885921 106799 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 453 6 1 6 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccn2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
CHEMBL314454 106799 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 453 6 1 6 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccn2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
11798504 97121 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 468 9 1 6 3.5 CCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL267695 97121 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 468 9 1 6 3.5 CCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10648135 9340 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 472 13 1 5 4.7 C/C=C/CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL111218 9340 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 472 13 1 5 4.7 C/C=C/CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
44314581 104875 None 0 Pig Binding pIC50 = 8.3 8.3 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 591 11 6 5 2.8 Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)NC(Cc1c[nH]cn1)C(=O)O 10.1021/jm9600914
CHEMBL311134 104875 None 0 Pig Binding pIC50 = 8.3 8.3 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 591 11 6 5 2.8 Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)NC(Cc1c[nH]cn1)C(=O)O 10.1021/jm9600914
11798504 97121 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 468 9 1 6 3.5 CCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL267695 97121 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 468 9 1 6 3.5 CCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
11113473 203367 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 472 6 1 5 6.3 CC(C)Oc1ccc2c(c1)C(c1ccc(C(C)C)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL65201 203367 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 472 6 1 5 6.3 CC(C)Oc1ccc2c(c1)C(c1ccc(C(C)C)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL2304006 209460 None 0 Pig Binding pIC50 = 8.3 8.3 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None O=C(O)C[C@H]1NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm9600914
44320419 107072 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 496 7 2 6 5.1 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCC(C(=O)O)CC1 10.1016/s0960-894x(00)00513-8
CHEMBL315805 107072 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 496 7 2 6 5.1 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCC(C(=O)O)CC1 10.1016/s0960-894x(00)00513-8
10576428 14585 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 473 8 2 6 4.3 COc1ccc(C(=O)/C(Cc2ccc(NC(C)=O)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL10905 14585 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 473 8 2 6 4.3 COc1ccc(C(=O)/C(Cc2ccc(NC(C)=O)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL1204673 14585 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 473 8 2 6 4.3 COc1ccc(C(=O)/C(Cc2ccc(NC(C)=O)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL328942 211314 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
18617318 105611 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 394 3 1 4 3.3 Cc1noc(NS(=O)(=O)c2ccccc2Br)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL312266 105611 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 394 3 1 4 3.3 Cc1noc(NS(=O)(=O)c2ccccc2Br)c1Br 10.1016/0960-894X(96)00441-6
10526002 8049 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 417 5 1 7 3.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccnc2)cc1 10.1021/jm9606507
CHEMBL10910 8049 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 417 5 1 7 3.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccnc2)cc1 10.1021/jm9606507
CHEMBL2304018 209472 None 0 Pig Binding pIC50 = 7.4 7.4 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Cl)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O 10.1021/jm9600914
18004820 16451 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 527 9 2 7 4.7 CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL12333 16451 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 527 9 2 7 4.7 CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
71456865 81700 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 632 14 2 11 3.7 COc1nc(NS(=O)(=O)NCc2ccccc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 10.1021/jm3009103
CHEMBL2163727 81700 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 632 14 2 11 3.7 COc1nc(NS(=O)(=O)NCc2ccccc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 10.1021/jm3009103
10504148 207257 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 459 10 1 5 6.7 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1ccccn1 10.1021/jm9707131
CHEMBL92965 207257 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 459 10 1 5 6.7 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1ccccn1 10.1021/jm9707131
104865 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
3494 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
392 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
CHEMBL957 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
DB00559 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
CHEMBL2369709 209650 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00152-J
CHEMBL405100 212541 None 0 Pig Binding pIC50 = 7.4 7.4 - 0
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
CHEMBL438820 213798 None 0 Pig Binding pIC50 = 7.4 7.4 - 0
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
10002033 101010 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 417 7 2 7 3.6 CCOC(=O)C(C)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL29448 101010 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 417 7 2 7 3.6 CCOC(=O)C(C)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
10718141 5221 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 444 5 1 7 3.6 COC(=O)c1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL10622 5221 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 444 5 1 7 3.6 COC(=O)c1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
10027018 98487 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 454 4 1 5 5.1 O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL275991 98487 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 454 4 1 5 5.1 O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
44279413 99950 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 400 2 2 3 3.3 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(Br)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL286395 99950 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 400 2 2 3 3.3 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(Br)cc21 10.1016/0960-894X(95)00230-Q
10716071 207314 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 401 7 1 5 5.4 O=[N+]([O-])c1ccc(OCc2ccsc2)cc1/C=C(/CO)c1ccccc1Cl 10.1021/jm970847e
CHEMBL93411 207314 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 401 7 1 5 5.4 O=[N+]([O-])c1ccc(OCc2ccsc2)cc1/C=C(/CO)c1ccccc1Cl 10.1021/jm970847e
44298330 101546 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 518 10 1 8 5.4 COC(=O)CCCc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Sc1cccc(OC)c1 10.1016/s0960-894x(00)00366-8
CHEMBL298340 101546 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 518 10 1 8 5.4 COC(=O)CCCc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Sc1cccc(OC)c1 10.1016/s0960-894x(00)00366-8
CHEMBL85341 215886 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
10792782 131362 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL368847 131362 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL147510 208776 None 0 Human Binding pIC50 = 6.4 6.4 - 0
The inhibitory constant was evaluated against Endothelin A receptorThe inhibitory constant was evaluated against Endothelin A receptor
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
10087191 101835 None 1 Human Binding pIC50 = 5.4 5.4 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3c(N)cccc23)c1C 10.1021/jm00029a001
CHEMBL30039 101835 None 1 Human Binding pIC50 = 5.4 5.4 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3c(N)cccc23)c1C 10.1021/jm00029a001
10087191 101835 None 1 Rat Binding pIC50 = 5.4 5.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3c(N)cccc23)c1C 10.1021/jm00008a013
CHEMBL30039 101835 None 1 Rat Binding pIC50 = 5.4 5.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3c(N)cccc23)c1C 10.1021/jm00008a013
5329 169474 None 119 Rat Binding pIC50 = 5.4 5.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 10.1021/jm00008a013
CHEMBL443 169474 None 119 Rat Binding pIC50 = 5.4 5.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 10.1021/jm00008a013
CHEMBL405709 212574 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
5329 169474 None 119 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 10.1021/jm00004a012
CHEMBL443 169474 None 119 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 10.1021/jm00004a012
44327619 207436 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 511 6 1 8 3.5 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C(C)(C)C)ccc2=O)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL94102 207436 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 511 6 1 8 3.5 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C(C)(C)C)ccc2=O)cc1 10.1016/S0960-894X(96)00617-8
44327714 207937 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 575 8 1 9 4.2 COc1ccc(-c2cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)n2)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL96935 207937 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 575 8 1 9 4.2 COc1ccc(-c2cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)n2)cc1 10.1016/S0960-894X(96)00617-8
182140 189095 None 32 Human Binding pIC50 = 4.4 4.4 - 0
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cellsDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells
ChEMBL 430 8 0 7 3.7 COC[C@@H]1Cc2cc(OC)c3c(c2[C@H](c2ccc(OC)c(OC)c2)[C@H]1COC)OCO3 10.1021/np50124a006
CHEMBL510130 189095 None 32 Human Binding pIC50 = 4.4 4.4 - 0
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cellsDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells
ChEMBL 430 8 0 7 3.7 COC[C@@H]1Cc2cc(OC)c3c(c2[C@H](c2ccc(OC)c(OC)c2)[C@H]1COC)OCO3 10.1021/np50124a006
44277130 99452 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 450 8 1 7 3.6 COc1cccc(Cn2nc(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2OCCO)c1 10.1016/s0960-894x(00)00232-8
CHEMBL283037 99452 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 450 8 1 7 3.6 COc1cccc(Cn2nc(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2OCCO)c1 10.1016/s0960-894x(00)00232-8
44277131 106833 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 380 5 1 3 4.0 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(F)cc3)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144603 106833 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 380 5 1 3 4.0 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(F)cc3)c2=O)c1 10.1016/s0960-894x(00)00232-8
44357135 116245 None 0 Pig Binding pIC50 = 4.4 4.4 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 642 10 6 8 -0.1 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)c2ccccc2NC=O)NC1=O 10.1021/jm00021a021
CHEMBL335863 116245 None 0 Pig Binding pIC50 = 4.4 4.4 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 642 10 6 8 -0.1 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)c2ccccc2NC=O)NC1=O 10.1021/jm00021a021
10814222 9550 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 470 10 1 6 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)cc2OC)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL112325 9550 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 470 10 1 6 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)cc2OC)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
18995992 99836 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 507 7 1 9 5.0 COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC 10.1016/0960-894X(96)00232-6
CHEMBL28563 99836 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 507 7 1 9 5.0 COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC 10.1016/0960-894X(96)00232-6
44339755 9777 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 551 12 1 7 2.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CN1CCCCS1(=O)=O 10.1021/jm980217s
CHEMBL113589 9777 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 551 12 1 7 2.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CN1CCCCS1(=O)=O 10.1021/jm980217s
10763680 120780 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 403 7 1 6 4.1 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1 10.1021/jm990378b
CHEMBL355413 120780 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 403 7 1 6 4.1 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1 10.1021/jm990378b
9894460 206707 None 9 Rat Binding pIC50 = 7.4 7.4 -24 3
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00617-8
CHEMBL313871 206707 None 9 Rat Binding pIC50 = 7.4 7.4 -24 3
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00617-8
CHEMBL8978 206707 None 9 Rat Binding pIC50 = 7.4 7.4 -24 3
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00617-8
10554410 120380 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 538 10 3 7 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)OC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL353320 120380 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 538 10 3 7 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)OC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
10916597 203313 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm031041j
CHEMBL64832 203313 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm031041j
CHEMBL304756 210973 None 0 Pig Binding pIC50 = 6.4 6.4 - 0
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00089a028
11058658 203246 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 409 7 1 5 4.8 CCCCC1=C(C(N)=O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL64558 203246 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 409 7 1 5 4.8 CCCCC1=C(C(N)=O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL337897 211598 None 0 Pig Binding pIC50 = 6.4 6.4 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
4642915 97935 None 1 Rat Binding pIC50 = 5.4 5.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 402 5 3 5 4.1 Cc1noc(NS(=O)(=O)c2ccc(N/C(S)=N/c3ccccc3)cc2)c1C 10.1021/jm00008a013
CHEMBL27256 97935 None 1 Rat Binding pIC50 = 5.4 5.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 402 5 3 5 4.1 Cc1noc(NS(=O)(=O)c2ccc(N/C(S)=N/c3ccccc3)cc2)c1C 10.1021/jm00008a013
44213925 111702 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 593 9 1 9 4.1 COc1ccc(C2=NN(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)C(=O)CC2)cc1OC 10.1016/S0960-894X(96)00617-8
CHEMBL328683 111702 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 593 9 1 9 4.1 COc1ccc(C2=NN(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)C(=O)CC2)cc1OC 10.1016/S0960-894X(96)00617-8
44266532 4499 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 401 3 1 6 4.5 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10211 4499 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 401 3 1 6 4.5 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
10816264 59927 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 539 9 4 5 5.0 Cc1sc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL173181 59927 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 539 9 4 5 5.0 Cc1sc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
10840476 131839 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 553 10 4 5 5.3 CCc1sc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL369420 131839 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 553 10 4 5 5.3 CCc1sc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
23445345 203058 None 0 Human Binding pIC50 = 5.4 5.4 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 378 5 1 7 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccccc2)c1C 10.1016/S0960-894X(97)00367-3
CHEMBL63611 203058 None 0 Human Binding pIC50 = 5.4 5.4 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 378 5 1 7 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccccc2)c1C 10.1016/S0960-894X(97)00367-3
10280531 162929 None 0 Human Binding pIC50 = 6.4 6.4 - 1
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 541 10 2 7 5.1 CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL417429 162929 None 0 Human Binding pIC50 = 6.4 6.4 - 1
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 541 10 2 7 5.1 CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10366742 107106 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 454 6 1 5 5.5 CCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(96)00496-9
CHEMBL316012 107106 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 454 6 1 5 5.5 CCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(96)00496-9
44371410 49419 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 439 5 1 5 5.5 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3C)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL156453 49419 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 439 5 1 5 5.5 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3C)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL406279 212600 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
44383187 60163 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 617 13 4 5 4.5 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCc1cccc(CCC(=O)O)c1 10.1016/0960-894X(95)00144-I
CHEMBL173974 60163 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 617 13 4 5 4.5 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCc1cccc(CCC(=O)O)c1 10.1016/0960-894X(95)00144-I
15296635 99553 None 0 Pig Binding pIC50 = 6.4 6.4 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 488 11 5 5 2.7 CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL283591 99553 None 0 Pig Binding pIC50 = 6.4 6.4 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 488 11 5 5 2.7 CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44279516 99849 None 0 Pig Binding pIC50 = 6.4 6.4 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 512 13 5 5 2.6 CC(C)C[C@H](NC(=O)Cc1cccs1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL285729 99849 None 0 Pig Binding pIC50 = 6.4 6.4 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 512 13 5 5 2.6 CC(C)C[C@H](NC(=O)Cc1cccs1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
15340613 106842 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 414 6 1 5 4.2 COc1cccc(Cn2[nH]c(-c3ccccc3)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144732 106842 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 414 6 1 5 4.2 COc1cccc(Cn2[nH]c(-c3ccccc3)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
44317215 205261 None 2 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 266 3 1 4 2.4 Cc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/0960-894X(96)00441-6
CHEMBL78952 205261 None 2 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 266 3 1 4 2.4 Cc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/0960-894X(96)00441-6
10816963 113327 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 574 12 2 7 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC)cc1 10.1021/jm990170q
CHEMBL331625 113327 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 574 12 2 7 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC)cc1 10.1021/jm990170q
CHEMBL1791015 208913 None 0 Pig Binding pIC50 = 5.4 5.4 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44368417 44647 None 0 Pig Binding pIC50 = 4.4 4.4 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 504 12 2 6 4.9 COc1ccc(CN(Cc2cc(OC)c(OC)c(OC)c2)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
CHEMBL152065 44647 None 0 Pig Binding pIC50 = 4.4 4.4 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 504 12 2 6 4.9 COc1ccc(CN(Cc2cc(OC)c(OC)c(OC)c2)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
10383833 100106 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc2c1 10.1021/jm00008a013
CHEMBL28751 100106 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc2c1 10.1021/jm00008a013
10383833 100106 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc2c1 10.1021/jm00004a012
CHEMBL28751 100106 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc2c1 10.1021/jm00004a012
CHEMBL265066 96813 None 0 Pig Binding pIC50 = 6.4 6.4 - 0
Tested for its inhibitory activity against Endothelin A receptorTested for its inhibitory activity against Endothelin A receptor
ChEMBL 646 8 2 13 5.8 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC(=O)C2=C(C)N=C(C)/C(=C(/O)OC)[C@@H]2c2cccc([N+](=O)[O-])c2)[C@H]1c1cccc([N+](=O)[O-])c1 10.1016/S0960-894X(01)81025-8
9913198 5318 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 484 5 1 6 4.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(C(F)(F)F)c2)cc1 10.1021/jm9606507
CHEMBL10676 5318 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 484 5 1 6 4.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(C(F)(F)F)c2)cc1 10.1021/jm9606507
11733450 203418 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 6 1 7 5.0 CCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL65658 203418 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 6 1 7 5.0 CCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10502577 12402 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 426 7 1 7 3.9 COc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm9700068
CHEMBL1185771 12402 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 426 7 1 7 3.9 COc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm9700068
CHEMBL432109 12402 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 426 7 1 7 3.9 COc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm9700068
10599829 97127 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 9 2 6 3.2 CCCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL267761 97127 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 9 2 6 3.2 CCCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
44266575 4641 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 459 6 1 7 5.2 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10302 4641 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 459 6 1 7 5.2 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
44317005 205024 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL76949 205024 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)c1C 10.1016/0960-894X(96)00441-6
10070783 97054 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL267094 97054 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
44298305 194586 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 504 10 2 7 5.3 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(=O)O)c1 10.1016/s0960-894x(00)00366-8
CHEMBL53097 194586 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 504 10 2 7 5.3 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(=O)O)c1 10.1016/s0960-894x(00)00366-8
44276948 106834 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 396 5 1 3 4.5 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(Cl)cc3)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144604 106834 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 396 5 1 3 4.5 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(Cl)cc3)c2=O)c1 10.1016/s0960-894x(00)00232-8
9820754 108560 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 371 3 0 5 4.4 COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL320236 108560 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 371 3 0 5 4.4 COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
10604167 12415 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 640 10 2 6 6.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL1185826 12415 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 640 10 2 6 6.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL434986 12415 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 640 10 2 6 6.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
10647172 206764 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 449 6 1 5 4.6 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2Cc2ccc(F)cc2)cc1 10.1021/jm9505369
CHEMBL9012 206764 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 449 6 1 5 4.6 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2Cc2ccc(F)cc2)cc1 10.1021/jm9505369
44265906 97267 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 441 9 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCOCC(C)C)cc1 10.1021/jm9505369
CHEMBL268902 97267 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 441 9 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCOCC(C)C)cc1 10.1021/jm9505369
18617377 205472 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 344 3 1 4 3.2 Cc1ccc(C)c(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
CHEMBL80484 205472 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 344 3 1 4 3.2 Cc1ccc(C)c(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
10668427 165342 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 395 7 1 6 3.8 N#Cc1ccc(OCc2ccnnc2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
CHEMBL423608 165342 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 395 7 1 6 3.8 N#Cc1ccc(OCc2ccnnc2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
10765750 163157 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 445 8 1 6 3.0 CC[S+]([O-])CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL417972 163157 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 445 8 1 6 3.0 CC[S+]([O-])CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
44383753 60064 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 466 5 1 5 5.7 Cc1cc(C)c(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL173761 60064 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 466 5 1 5 5.7 Cc1cc(C)c(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
44439105 168708 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 848 26 2 12 6.5 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOc2ccc(-c3ccccc3S(=O)(=O)Nc3ccno3)c(CN(C)C(=O)CC(C)(C)C)c2)cc1 10.1016/j.bmcl.2006.10.009
CHEMBL436821 168708 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 848 26 2 12 6.5 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOc2ccc(-c3ccccc3S(=O)(=O)Nc3ccno3)c(CN(C)C(=O)CC(C)(C)C)c2)cc1 10.1016/j.bmcl.2006.10.009
10357554 97562 None 1 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1016/0960-894X(96)00441-6
CHEMBL27065 97562 None 1 Human Binding pIC50 = 6.4 6.4 - 0
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1016/0960-894X(96)00441-6
10972369 168066 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 448 6 3 6 4.9 COc1ccc(C2=C(C(=O)O)C(c3ccc(O)c(O)c3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL432489 168066 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 448 6 3 6 4.9 COc1ccc(C2=C(C(=O)O)C(c3ccc(O)c(O)c3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
11801544 61775 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 589 10 4 6 5.1 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2C3CC4CC(C3)CC2C4)nc1C(=O)O 10.1021/jm950592+
CHEMBL177261 61775 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 589 10 4 6 5.1 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2C3CC4CC(C3)CC2C4)nc1C(=O)O 10.1021/jm950592+
CHEMBL135907 208733 None 0 Pig Binding pIC50 = 6.4 6.4 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
23445562 100614 None 0 Human Binding pIC50 = 5.4 5.4 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 398 5 1 7 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccccc2)c1Cl 10.1016/S0960-894X(97)00367-3
CHEMBL291891 100614 None 0 Human Binding pIC50 = 5.4 5.4 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 398 5 1 7 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccccc2)c1Cl 10.1016/S0960-894X(97)00367-3
CHEMBL438194 213751 None 14 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
CHEMBL34540 211706 None 14 Rat Binding pIC50 = 4.4 4.4 - 0
Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.
ChEMBL None None None None 10.1021/jm00087a001
104865 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
Antagonist activity at ET-A receptor (unknown origin)Antagonist activity at ET-A receptor (unknown origin)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.5b01781
3494 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
Antagonist activity at ET-A receptor (unknown origin)Antagonist activity at ET-A receptor (unknown origin)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.5b01781
392 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
Antagonist activity at ET-A receptor (unknown origin)Antagonist activity at ET-A receptor (unknown origin)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.5b01781
CHEMBL957 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
Antagonist activity at ET-A receptor (unknown origin)Antagonist activity at ET-A receptor (unknown origin)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.5b01781
DB00559 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
Antagonist activity at ET-A receptor (unknown origin)Antagonist activity at ET-A receptor (unknown origin)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.5b01781
10839947 117300 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 530 9 2 6 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL339657 117300 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 530 9 2 6 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
104865 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
Displacement of 125I-ET1 from human smooth muscle ETA receptorDisplacement of 125I-ET1 from human smooth muscle ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
3494 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
Displacement of 125I-ET1 from human smooth muscle ETA receptorDisplacement of 125I-ET1 from human smooth muscle ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
392 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
Displacement of 125I-ET1 from human smooth muscle ETA receptorDisplacement of 125I-ET1 from human smooth muscle ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
CHEMBL957 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
Displacement of 125I-ET1 from human smooth muscle ETA receptorDisplacement of 125I-ET1 from human smooth muscle ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
DB00559 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
Displacement of 125I-ET1 from human smooth muscle ETA receptorDisplacement of 125I-ET1 from human smooth muscle ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
104865 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm3009103
3494 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm3009103
392 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm3009103
CHEMBL957 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm3009103
DB00559 705 None 99 Human Binding pIC50 = 7.4 7.4 1 4
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm3009103
10741025 181679 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 424 6 1 6 4.5 Cc1cc(C)cc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 10.1021/jm9700068
CHEMBL47765 181679 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 424 6 1 6 4.5 Cc1cc(C)cc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 10.1021/jm9700068
CHEMBL347948 211712 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL None None None CC[C@H](C)[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81219-1
18184234 62207 None 0 Human Binding pIC50 = 7.4 7.4 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 605 15 2 10 4.2 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL177802 62207 None 0 Human Binding pIC50 = 7.4 7.4 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 605 15 2 10 4.2 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
10599230 206993 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 440 8 2 6 2.8 CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm031041j
CHEMBL9141 206993 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 440 8 2 6 2.8 CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm031041j
10599230 206993 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 440 8 2 6 2.8 CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9141 206993 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 440 8 2 6 2.8 CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
11767189 9956 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 11 1 10 5.8 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2cnc3ccccc3n2)c1 10.1021/jm0102304
CHEMBL114704 9956 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 11 1 10 5.8 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2cnc3ccccc3n2)c1 10.1021/jm0102304
10793053 11456 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 564 9 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL1180363 11456 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 564 9 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL123994 11456 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 564 9 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
15340617 99235 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 464 8 1 7 3.7 COc1cccc(Cn2nc(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2OCC(=O)O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL281677 99235 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 464 8 1 7 3.7 COc1cccc(Cn2nc(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2OCC(=O)O)c1 10.1016/s0960-894x(00)00232-8
44386621 61275 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
CHEMBL176653 61275 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
10650331 132570 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 551 10 3 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)N(C)C(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL369821 132570 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 551 10 3 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)N(C)C(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
56678451 63324 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 25 8 8 4.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(c1ccccc1)c1ccccc1)N(C)C(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
CHEMBL1793927 63324 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 25 8 8 4.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(c1ccccc1)c1ccccc1)N(C)C(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
10205429 61604 None 0 Human Binding pIC50 = 6.3 6.3 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 470 8 2 9 2.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL177111 61604 None 0 Human Binding pIC50 = 6.3 6.3 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 470 8 2 9 2.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
71458717 81668 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 433 9 2 10 1.5 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCO 10.1021/jm3009103
CHEMBL2163696 81668 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 433 9 2 10 1.5 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCO 10.1021/jm3009103
10598840 60492 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 432 9 1 5 4.7 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)cc(OC)c2)cc1 10.1021/jm031041j
CHEMBL175545 60492 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 432 9 1 5 4.7 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)cc(OC)c2)cc1 10.1021/jm031041j
10670372 97245 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)cc(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL268754 97245 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)cc(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
44314664 204694 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 615 12 5 4 5.1 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CCCC1)C(=O)O 10.1021/jm9600914
CHEMBL74000 204694 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 615 12 5 4 5.1 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CCCC1)C(=O)O 10.1021/jm9600914
76330201 85347 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 526 6 1 7 4.5 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(Cl)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261363 85347 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 526 6 1 7 4.5 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(Cl)ccc12 10.1007/s00044-004-0021-y
10479787 59613 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 6 1 5 5.3 Cc1cc(C)c(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL171972 59613 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 6 1 5 5.3 Cc1cc(C)c(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
18995988 100335 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 389 6 1 4 5.5 COc1cccc(Sc2c(C(=O)O)n(Cc3ccccc3)c3ccccc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL28948 100335 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 389 6 1 4 5.5 COc1cccc(Sc2c(C(=O)O)n(Cc3ccccc3)c3ccccc23)c1 10.1016/0960-894X(96)00232-6
10029811 97954 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 525 8 2 5 6.4 Cc1noc(NS(=O)(=O)c2cccc3c(NC(=O)CC(c4ccccc4)c4ccccc4)cccc23)c1C 10.1021/jm00008a013
CHEMBL27262 97954 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 525 8 2 5 6.4 Cc1noc(NS(=O)(=O)c2cccc3c(NC(=O)CC(c4ccccc4)c4ccccc4)cccc23)c1C 10.1021/jm00008a013
44279127 99486 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 432 3 2 3 4.8 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(Cl)cc3)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL283200 99486 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 432 3 2 3 4.8 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(Cl)cc3)cc21 10.1016/0960-894X(95)00230-Q
10815168 168149 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 497 5 2 6 5.2 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(C(C)(C)C)cc2)c1Br 10.1021/jm9608366
CHEMBL433074 168149 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 497 5 2 6 5.2 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(C(C)(C)C)cc2)c1Br 10.1021/jm9608366
9869444 97244 None 0 Human Binding pIC50 = 7.3 7.3 - 1
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 10.1016/0960-894X(96)00170-9
CHEMBL268751 97244 None 0 Human Binding pIC50 = 7.3 7.3 - 1
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 10.1016/0960-894X(96)00170-9
CHEMBL342440 211672 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CCC[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
23445250 168104 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 468 6 1 5 5.8 Cc1cc(CC(C)C)ccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL432815 168104 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 468 6 1 5 5.8 Cc1cc(CC(C)C)ccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
44316515 205002 None 2 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 360 4 1 5 2.9 COc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
CHEMBL76779 205002 None 2 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 360 4 1 5 2.9 COc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
44314472 103796 None 0 Pig Binding pIC50 = 6.3 6.3 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 594 13 5 5 4.2 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL309003 103796 None 0 Pig Binding pIC50 = 6.3 6.3 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 594 13 5 5 4.2 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
10626177 60389 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 535 11 4 5 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)CC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL174871 60389 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 535 11 4 5 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)CC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
44283420 161790 None 0 Pig Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 594 13 5 5 4.2 CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL414175 161790 None 0 Pig Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 594 13 5 5 4.2 CCCC[C@H](NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
23548251 81679 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 661 16 1 14 4.0 COc1cc(OC)nc(OCCOc2nc(-c3ncccn3)nc(NS(=O)(=O)CCc3ccccc3)c2Oc2ccccc2OC)n1 10.1021/jm3009103
CHEMBL2163707 81679 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 661 16 1 14 4.0 COc1cc(OC)nc(OCCOc2nc(-c3ncccn3)nc(NS(=O)(=O)CCc3ccccc3)c2Oc2ccccc2OC)n1 10.1021/jm3009103
11801523 8254 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 588 16 1 7 5.3 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCC)cc1 10.1021/jm970101g
CHEMBL109242 8254 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 588 16 1 7 5.3 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCC)cc1 10.1021/jm970101g
10961960 202874 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 487 8 1 7 4.4 CCCCC1=C(C(=O)NS(C)(=O)=O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL62633 202874 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 487 8 1 7 4.4 CCCCC1=C(C(=O)NS(C)(=O)=O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL304260 210971 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
9830495 131147 None 0 Human Binding pIC50 = 7.3 7.3 - 1
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 618 14 2 9 5.0 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL368617 131147 None 0 Human Binding pIC50 = 7.3 7.3 - 1
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 618 14 2 9 5.0 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
137661460 159373 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 565 10 2 9 4.4 C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4100579 159373 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 565 10 2 9 4.4 C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL2370255 209817 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10645550 97350 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 5 1 6 3.8 COc1ccccc1C1(O)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1ccccc1 10.1021/jm9606507
CHEMBL269461 97350 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 5 1 6 3.8 COc1ccccc1C1(O)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1ccccc1 10.1021/jm9606507
11145841 100953 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 528 9 1 6 6.9 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC3CCCC3)cc1)O2 10.1021/jm010382z
CHEMBL294127 100953 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 528 9 1 6 6.9 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC3CCCC3)cc1)O2 10.1021/jm010382z
44279129 106993 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 428 4 2 4 4.2 COc1ccccc1-c1ccc2c(c1)C(=O)c1ccccc1[C@@H]1[C@H](C(=O)O)[C@H](C(=O)O)[C@H]21 10.1016/0960-894X(95)00230-Q
CHEMBL31524 106993 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 428 4 2 4 4.2 COc1ccccc1-c1ccc2c(c1)C(=O)c1ccccc1[C@@H]1[C@H](C(=O)O)[C@H](C(=O)O)[C@H]21 10.1016/0960-894X(95)00230-Q
44277245 106845 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 392 6 1 4 3.9 COc1ccc(Cc2c(C(F)(F)F)[nH]n(Cc3cccc(OC)c3)c2=O)cc1 10.1016/s0960-894x(00)00232-8
CHEMBL3144736 106845 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 392 6 1 4 3.9 COc1ccc(Cc2c(C(F)(F)F)[nH]n(Cc3cccc(OC)c3)c2=O)cc1 10.1016/s0960-894x(00)00232-8
44385522 59624 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 642 13 2 11 4.2 CCS(=O)(=O)NCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL172029 59624 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 642 13 2 11 4.2 CCS(=O)(=O)NCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9808545 11450 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 588 11 2 7 5.2 COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 10.1021/jm990171i
CHEMBL1180353 11450 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 588 11 2 7 5.2 COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 10.1021/jm990171i
CHEMBL123408 11450 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 588 11 2 7 5.2 COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 10.1021/jm990171i
10571380 60074 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 373 7 1 4 4.7 Cc1ccccc1C(Oc1cc(OCc2ccccc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL173838 60074 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 373 7 1 4 4.7 Cc1ccccc1C(Oc1cc(OCc2ccccc2)ccc1C#N)C(=O)O 10.1021/jm990378b
9845967 11091 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL10801 11091 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL1178000 11091 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL51530 11091 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL433853 213645 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)(C)S)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44371450 48862 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(OC)c(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c1 10.1016/s0960-894x(99)00040-2
CHEMBL155937 48862 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(OC)c(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c1 10.1016/s0960-894x(99)00040-2
15453210 205244 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 376 5 1 6 2.6 COc1ccc(S(=O)(=O)Nc2onc(C)c2Br)cc1OC 10.1016/0960-894X(96)00441-6
CHEMBL78853 205244 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 376 5 1 6 2.6 COc1ccc(S(=O)(=O)Nc2onc(C)c2Br)cc1OC 10.1016/0960-894X(96)00441-6
44316458 205439 None 2 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 408 3 1 4 3.6 Cc1noc(NS(=O)(=O)c2cc(Br)ccc2Br)c1C 10.1016/0960-894X(96)00441-6
CHEMBL80317 205439 None 2 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 408 3 1 4 3.6 Cc1noc(NS(=O)(=O)c2cc(Br)ccc2Br)c1C 10.1016/0960-894X(96)00441-6
10404449 99502 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 331 4 1 5 3.0 Cc1cnoc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm00008a013
CHEMBL283300 99502 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 331 4 1 5 3.0 Cc1cnoc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm00008a013
9865706 98132 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 400 4 1 5 4.1 Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL273613 98132 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 400 4 1 5 4.1 Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
44385523 61062 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 666 13 2 9 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL176418 61062 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 666 13 2 9 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL409777 212782 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
9957883 98655 None 0 Human Binding pIC50 = 8.3 8.3 - 1
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 507 7 1 9 5.0 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
CHEMBL27732 98655 None 0 Human Binding pIC50 = 8.3 8.3 - 1
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 507 7 1 9 5.0 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
10626031 109696 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 529 13 1 7 2.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1C(=O)CCC1=O 10.1021/jm980217s
CHEMBL322799 109696 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 529 13 1 7 2.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1C(=O)CCC1=O 10.1021/jm980217s
10767210 111313 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 484 12 1 4 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2cccc(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL326719 111313 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 484 12 1 4 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2cccc(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
9871837 15201 None 0 Human Binding pIC50 = 8.3 8.3 - 1
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 535 10 2 7 4.9 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1039/C4MD00499J
CHEMBL12106 15201 None 0 Human Binding pIC50 = 8.3 8.3 - 1
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 535 10 2 7 4.9 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1039/C4MD00499J
44458650 84901 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 521 7 2 8 2.7 COc1ccccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
CHEMBL22367 84901 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 521 7 2 8 2.7 COc1ccccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
10619391 60236 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL173251 60236 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL174092 60236 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
10547407 78363 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1[C@H](Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL2110232 78363 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1[C@H](Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
10453733 112309 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 402 9 1 5 4.8 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2cccnc2)ccc1C#N 10.1021/jm9707131
CHEMBL329181 112309 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 402 9 1 5 4.8 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2cccnc2)ccc1C#N 10.1021/jm9707131
9953204 207430 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm9707131
CHEMBL94071 207430 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm9707131
10210086 61279 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 571 10 2 12 3.0 C#CCOc1nc(-c2ccnc(-c3nn[nH]n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL176664 61279 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 571 10 2 12 3.0 C#CCOc1nc(-c2ccnc(-c3nn[nH]n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10361107 162046 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 5 2 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(NC(C)C)cccc23)c1C 10.1021/jm00004a012
CHEMBL416026 162046 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 5 2 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(NC(C)C)cccc23)c1C 10.1021/jm00004a012
CHEMBL64271 215851 None 0 Pig Binding pIC50 = 8.3 8.3 - 0
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
10281929 9391 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 588 16 1 7 5.3 CCCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
CHEMBL111517 9391 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 588 16 1 7 5.3 CCCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
10553490 181114 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 501 8 3 10 2.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2OCCO)OCO3)c1Cl 10.1021/jm9608366
CHEMBL47604 181114 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 501 8 3 10 2.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2OCCO)OCO3)c1Cl 10.1021/jm9608366
44386921 61278 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 384 5 1 6 3.8 COC1=C(C(=O)O)[C@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm031041j
CHEMBL176661 61278 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 384 5 1 6 3.8 COC1=C(C(=O)O)[C@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm031041j
10721344 7538 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 548 13 1 8 3.0 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCOC 10.1021/jm970101g
CHEMBL108748 7538 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 548 13 1 8 3.0 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCOC 10.1021/jm970101g
10918390 19319 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 522 12 1 5 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 10.1021/jm010237l
CHEMBL129060 19319 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 522 12 1 5 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 10.1021/jm010237l
9807178 202989 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 384 5 1 6 3.8 COC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL63121 202989 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 384 5 1 6 3.8 COC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10767280 108666 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 486 14 1 5 5.1 C=C(C)CCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL320763 108666 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 486 14 1 5 5.1 C=C(C)CCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
44458669 84671 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 505 6 2 7 3.0 Cc1ccccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
CHEMBL22249 84671 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 505 6 2 7 3.0 Cc1ccccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
107810 1682 None 30 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 10.1016/0960-894X(95)00144-I
998 1682 None 30 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 10.1016/0960-894X(95)00144-I
CHEMBL352396 1682 None 30 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 10.1016/0960-894X(95)00144-I
22009947 85342 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261358 85342 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
9984193 101155 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1021/jm031041j
CHEMBL295440 101155 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1021/jm031041j
9984193 101155 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL295440 101155 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10649119 11436 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 502 8 2 6 4.1 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL1180318 11436 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 502 8 2 6 4.1 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL121761 11436 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 502 8 2 6 4.1 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2)cc1 10.1021/jm990171i
73669994 117628 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 429 9 1 7 4.7 N#Cc1ccc(OCc2ccc3nonc3c2)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
CHEMBL3400996 117628 None 0 Rat Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 429 9 1 7 4.7 N#Cc1ccc(OCc2ccc3nonc3c2)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
44314750 165650 None 0 Pig Binding pIC50 = 8.3 8.3 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL424422 165650 None 0 Pig Binding pIC50 = 8.3 8.3 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
10140965 101170 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 7 3 9 3.0 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CCO)OCO3)c1Cl 10.1021/jm9608366
CHEMBL295588 101170 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 7 3 9 3.0 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CCO)OCO3)c1Cl 10.1021/jm9608366
44283419 100315 None 0 Pig Binding pIC50 = 8.3 8.3 - 0
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL289349 100315 None 0 Pig Binding pIC50 = 8.3 8.3 - 0
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
44314905 205045 None 0 Pig Binding pIC50 = 8.2 8.2 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 567 12 5 4 4.0 CCCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
CHEMBL77083 205045 None 0 Pig Binding pIC50 = 8.2 8.2 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 567 12 5 4 4.0 CCCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
44333867 4640 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 403 4 1 5 4.1 COc1ccc([C@@H]2c3nc(C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL103001 4640 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 403 4 1 5 4.1 COc1ccc([C@@H]2c3nc(C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
10415822 129817 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 579 9 3 7 4.7 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCOC23CCCCC3)nc1C(=O)O 10.1021/jm950592+
CHEMBL367551 129817 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 579 9 3 7 4.7 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCOC23CCCCC3)nc1C(=O)O 10.1021/jm950592+
11798998 206833 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 10 1 6 3.9 CCCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9050 206833 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 10 1 6 3.9 CCCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
122272 97095 None 31 Human Binding pIC50 = 8.2 8.2 1 2
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1016/0960-894X(96)00441-6
CHEMBL267458 97095 None 31 Human Binding pIC50 = 8.2 8.2 1 2
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1016/0960-894X(96)00441-6
10415348 61086 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 557 9 3 6 4.8 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCc3ccccc32)nc1C(=O)O 10.1021/jm950592+
CHEMBL176514 61086 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 557 9 3 6 4.8 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCc3ccccc32)nc1C(=O)O 10.1021/jm950592+
CHEMBL438733 213789 None 0 Pig Binding pIC50 = 8.2 8.2 - 0
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]2CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N2)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00077a013
10647642 8098 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 6 2 7 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(C(=O)O)c2)cc1 10.1021/jm9606507
CHEMBL10915 8098 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 6 2 7 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(C(=O)O)c2)cc1 10.1021/jm9606507
11799625 113796 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2ccc(C)c(C)c2)cc1 10.1021/jm990170q
CHEMBL332431 113796 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2ccc(C)c(C)c2)cc1 10.1021/jm990170q
9871561 174798 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 527 10 2 8 4.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cc2)nc(C(F)(F)F)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4562189 174798 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 527 10 2 8 4.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cc2)nc(C(F)(F)F)nc1OCCO 10.1016/j.bmcl.2016.06.014
9873255 59632 None 0 Human Binding pIC50 = 7.3 7.3 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 591 14 2 10 3.8 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL172071 59632 None 0 Human Binding pIC50 = 7.3 7.3 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 591 14 2 10 3.8 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
122272 97095 None 31 Human Binding pIC50 = 7.3 7.3 1 2
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm9604585
CHEMBL267458 97095 None 31 Human Binding pIC50 = 7.3 7.3 1 2
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm9604585
10553017 98105 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 488 7 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)c2ccccc2)cc1 10.1021/jm9505369
CHEMBL273476 98105 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 488 7 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)c2ccccc2)cc1 10.1021/jm9505369
10502023 122390 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 416 7 1 5 4.4 COc1cccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)c1 10.1021/jm031041j
CHEMBL360066 122390 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 416 7 1 5 4.4 COc1cccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)c1 10.1021/jm031041j
CHEMBL384728 212332 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
3370402 105789 None 5 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 252 3 1 4 2.1 Cc1noc(NS(=O)(=O)c2ccccc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL312670 105789 None 5 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 252 3 1 4 2.1 Cc1noc(NS(=O)(=O)c2ccccc2)c1C 10.1016/0960-894X(96)00441-6
10740614 98306 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 5 1 6 3.8 COc1cccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)c1 10.1021/jm9606507
CHEMBL274857 98306 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 5 1 6 3.8 COc1cccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)c1 10.1021/jm9606507
10714851 111923 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 381 7 1 5 4.9 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1ccccc1 10.1021/jm970847e
CHEMBL328786 111923 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 381 7 1 5 4.9 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1ccccc1 10.1021/jm970847e
44211959 55434 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 620 12 1 9 5.5 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(C)(=O)=O)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL16197 55434 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 620 12 1 9 5.5 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(C)(=O)=O)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
44368480 44606 None 0 Pig Binding pIC50 = 5.3 5.3 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 495 13 1 7 4.4 COc1ccc(CC(C(=O)O)N(Cc2ccc(OC)cc2)Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/s0960-894x(01)00009-9
CHEMBL152034 44606 None 0 Pig Binding pIC50 = 5.3 5.3 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 495 13 1 7 4.4 COc1ccc(CC(C(=O)O)N(Cc2ccc(OC)cc2)Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/s0960-894x(01)00009-9
10017402 101890 None 2 Rat Binding pIC50 = 5.3 5.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 295 5 2 5 2.5 CCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00008a013
CHEMBL30078 101890 None 2 Rat Binding pIC50 = 5.3 5.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 295 5 2 5 2.5 CCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00008a013
44328057 96892 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 986 26 9 9 4.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1cccnc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL265734 96892 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 986 26 9 9 4.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1cccnc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL2370253 209815 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44279351 99942 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 412 3 2 3 4.5 Cc1ccccc1-c1ccc2c(c1)C(=O)c1ccccc1[C@@H]1[C@H](C(=O)O)[C@H](C(=O)O)[C@H]21 10.1016/0960-894X(95)00230-Q
CHEMBL286333 99942 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 412 3 2 3 4.5 Cc1ccccc1-c1ccc2c(c1)C(=O)c1ccccc1[C@@H]1[C@H](C(=O)O)[C@H](C(=O)O)[C@H]21 10.1016/0960-894X(95)00230-Q
31771 96964 None 37 Rat Binding pIC50 = 5.3 5.3 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/s0960-894x(00)00366-8
CHEMBL26630 96964 None 37 Rat Binding pIC50 = 5.3 5.3 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/s0960-894x(00)00366-8
10017402 101890 None 2 Rat Binding pIC50 = 5.3 5.3 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 295 5 2 5 2.5 CCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00004a012
CHEMBL30078 101890 None 2 Rat Binding pIC50 = 5.3 5.3 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 295 5 2 5 2.5 CCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00004a012
10454873 96420 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 421 6 1 5 4.6 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1Cc1ccccc1 10.1021/jm00008a013
CHEMBL26203 96420 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 421 6 1 5 4.6 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1Cc1ccccc1 10.1021/jm00008a013
44383536 120395 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Tested for binding affinity towards rabbit Endothelin A receptorTested for binding affinity towards rabbit Endothelin A receptor
ChEMBL 362 3 2 5 2.9 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 10.1016/s0960-894x(00)00136-0
CHEMBL353502 120395 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Tested for binding affinity towards rabbit Endothelin A receptorTested for binding affinity towards rabbit Endothelin A receptor
ChEMBL 362 3 2 5 2.9 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 10.1016/s0960-894x(00)00136-0
10671298 203450 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 450 6 1 6 3.7 CCOc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL6588 203450 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 450 6 1 6 3.7 CCOc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
10789830 97016 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 453 4 1 4 3.7 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(I)cn3)cccc12 10.1021/jm9604585
CHEMBL266684 97016 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 453 4 1 4 3.7 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(I)cn3)cccc12 10.1021/jm9604585
10740942 203539 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 422 4 2 6 3.0 CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3O)cccc12 10.1021/jm9604585
CHEMBL6647 203539 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 422 4 2 6 3.0 CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3O)cccc12 10.1021/jm9604585
10595728 203548 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 376 4 1 5 3.5 Cc1cc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nnc1Cl 10.1021/jm9604585
CHEMBL6660 203548 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 376 4 1 5 3.5 Cc1cc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nnc1Cl 10.1021/jm9604585
10644647 120498 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 399 7 1 5 5.1 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccc(Cl)cc1 10.1021/jm990378b
CHEMBL354428 120498 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 399 7 1 5 5.1 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccc(Cl)cc1 10.1021/jm990378b
9845562 4739 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 10.1021/jm9606507
CHEMBL10374 4739 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 10.1021/jm9606507
44279535 104134 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 527 11 5 4 3.2 CC(C)C[C@H](NC(=O)N1C(C)CCCC1C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL30944 104134 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 527 11 5 4 3.2 CC(C)C[C@H](NC(=O)N1C(C)CCCC1C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44314675 98126 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)CC)C(=O)O 10.1021/jm9600914
CHEMBL273583 98126 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)CC)C(=O)O 10.1021/jm9600914
CHEMBL2304005 209459 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O 10.1021/jm9600914
9955093 166294 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 443 7 1 5 5.2 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1Br 10.1021/jm990378b
CHEMBL427117 166294 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 443 7 1 5 5.2 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1Br 10.1021/jm990378b
10281606 129670 None 0 Human Binding pIC50 = 7.3 7.3 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 575 9 2 10 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL367382 129670 None 0 Human Binding pIC50 = 7.3 7.3 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 575 9 2 10 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
9809270 131338 None 0 Human Binding pIC50 = 7.3 7.3 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 622 14 2 12 2.3 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL368738 131338 None 0 Human Binding pIC50 = 7.3 7.3 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 622 14 2 12 2.3 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
10896930 9820 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2cccnn2)c1 10.1021/jm0102304
CHEMBL113888 9820 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2cccnn2)c1 10.1021/jm0102304
44373550 119848 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 331 3 2 5 2.1 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1Br 10.1021/jm00004a012
CHEMBL348641 119848 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 331 3 2 5 2.1 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1Br 10.1021/jm00004a012
10647182 109720 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 449 8 2 4 3.9 CCCN(C)C(=O)CN1C[C@H](c2ccc3cc[nH]c3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL322935 109720 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 449 8 2 4 3.9 CCCN(C)C(=O)CN1C[C@H](c2ccc3cc[nH]c3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10579195 131337 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 584 10 5 4 5.7 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(-c2ccccc2)[nH]1 10.1021/jm950591h
CHEMBL368711 131337 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 584 10 5 4 5.7 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(-c2ccccc2)[nH]1 10.1021/jm950591h
10531664 168540 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 601 10 4 5 6.4 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(-c2ccccc2)s1 10.1021/jm950591h
CHEMBL435537 168540 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 601 10 4 5 6.4 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(-c2ccccc2)s1 10.1021/jm950591h
9897092 59934 None 0 Human Binding pIC50 = 5.3 5.3 - 1
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 779 17 2 13 6.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL173201 59934 None 0 Human Binding pIC50 = 5.3 5.3 - 1
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 779 17 2 13 6.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
23445523 60019 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 472 6 1 8 3.9 Cc1noc(NS(=O)(=O)c2sccc2COc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
CHEMBL173557 60019 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 472 6 1 8 3.9 Cc1noc(NS(=O)(=O)c2sccc2COc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
9961347 11960 None 1 Human Binding pIC50 = 4.3 4.3 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 664 13 2 7 6.6 Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C 10.1021/jm990171i
CHEMBL1182945 11960 None 1 Human Binding pIC50 = 4.3 4.3 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 664 13 2 7 6.6 Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C 10.1021/jm990171i
CHEMBL273642 11960 None 1 Human Binding pIC50 = 4.3 4.3 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 664 13 2 7 6.6 Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C 10.1021/jm990171i
10764220 207082 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 413 8 1 6 3.3 CCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9189 207082 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 413 8 1 6 3.3 CCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10907399 202954 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 516 11 1 6 6.8 CCCCOc1ccc(C2Oc3ccc(OCCCC)cc3C(c3ccc4c(c3)OCO4)=C2C(=O)O)cc1 10.1021/jm010382z
CHEMBL62976 202954 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 516 11 1 6 6.8 CCCCOc1ccc(C2Oc3ccc(OCCCC)cc3C(c3ccc4c(c3)OCO4)=C2C(=O)O)cc1 10.1021/jm010382z
10745212 131545 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 548 10 5 4 4.9 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C2CC2)[nH]1 10.1021/jm950591h
CHEMBL369257 131545 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 548 10 5 4 4.9 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C2CC2)[nH]1 10.1021/jm950591h
10550844 97307 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 435 5 1 6 3.7 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)c2ccco2)cc1 10.1021/jm9505369
CHEMBL269140 97307 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 435 5 1 6 3.7 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)c2ccco2)cc1 10.1021/jm9505369
10548721 59656 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 395 8 1 6 4.4 COc1ccccc1C(Oc1cc(OCc2ccsc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL172164 59656 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 395 8 1 6 4.4 COc1ccccc1C(Oc1cc(OCc2ccsc2)ccc1C#N)C(=O)O 10.1021/jm990378b
44316768 205241 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 358 4 1 4 3.4 CCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
CHEMBL78830 205241 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 358 4 1 4 3.4 CCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
44279458 99716 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 531 13 6 5 2.0 CC(C)C[C@H](NC(=O)N(CCO)C(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL284785 99716 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 531 13 6 5 2.0 CC(C)C[C@H](NC(=O)N(CCO)C(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
9910709 59346 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 433 7 1 5 5.4 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1C(F)(F)F 10.1021/jm990378b
CHEMBL170715 59346 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 433 7 1 5 5.4 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1C(F)(F)F 10.1021/jm990378b
10144372 166052 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 562 10 2 11 3.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL425682 166052 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 562 10 2 11 3.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
10344511 59681 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 466 5 1 5 5.7 Cc1cc(C)c(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL172248 59681 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 466 5 1 5 5.7 Cc1cc(C)c(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
44279290 107026 None 0 Pig Binding pIC50 = 6.3 6.3 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 547 11 5 4 3.0 CC(C)C[C@H](NC(=O)N1CCc2ccccc2C1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31546 107026 None 0 Pig Binding pIC50 = 6.3 6.3 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 547 11 5 4 3.0 CC(C)C[C@H](NC(=O)N1CCc2ccccc2C1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
10971076 202861 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 386 3 1 4 4.7 Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm010382z
CHEMBL62585 202861 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 386 3 1 4 4.7 Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm010382z
44279128 106910 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 428 4 2 4 4.2 COc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 10.1016/0960-894X(95)00230-Q
CHEMBL31469 106910 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 428 4 2 4 4.2 COc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 10.1016/0960-894X(95)00230-Q
44298393 199829 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 432 6 1 6 5.2 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2C)c1 10.1016/s0960-894x(00)00366-8
CHEMBL59425 199829 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 432 6 1 6 5.2 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2C)c1 10.1016/s0960-894x(00)00366-8
CHEMBL136583 208737 None 0 Pig Binding pIC50 = 6.3 6.3 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10546317 207164 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 358 8 1 2 5.7 O=C(O)CC/C(=C/c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
CHEMBL92402 207164 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 358 8 1 2 5.7 O=C(O)CC/C(=C/c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
10106336 97904 None 8 Rat Binding pIC50 = 4.3 4.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 254 3 2 5 1.5 Cc1cc(NS(=O)(=O)c2ccc(O)cc2)no1 10.1021/jm00008a013
CHEMBL27248 97904 None 8 Rat Binding pIC50 = 4.3 4.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 254 3 2 5 1.5 Cc1cc(NS(=O)(=O)c2ccc(O)cc2)no1 10.1021/jm00008a013
18617394 105627 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 294 3 1 4 3.0 Cc1cc(C)c(S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/0960-894X(96)00441-6
CHEMBL312372 105627 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 294 3 1 4 3.0 Cc1cc(C)c(S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/0960-894X(96)00441-6
10106336 97904 None 8 Rat Binding pIC50 = 4.3 4.3 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 254 3 2 5 1.5 Cc1cc(NS(=O)(=O)c2ccc(O)cc2)no1 10.1021/jm00004a012
CHEMBL27248 97904 None 8 Rat Binding pIC50 = 4.3 4.3 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 254 3 2 5 1.5 Cc1cc(NS(=O)(=O)c2ccc(O)cc2)no1 10.1021/jm00004a012
10815167 101191 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 497 7 2 6 5.4 CCC(C)c1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
CHEMBL295697 101191 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 497 7 2 6 5.4 CCC(C)c1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
23445313 165635 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 470 6 1 6 5.1 Cc1cc(C)c(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
CHEMBL424371 165635 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 470 6 1 6 5.1 Cc1cc(C)c(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
44279516 99849 None 0 Pig Binding pIC50 = 6.3 6.3 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 512 13 5 5 2.6 CC(C)C[C@H](NC(=O)Cc1cccs1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL285729 99849 None 0 Pig Binding pIC50 = 6.3 6.3 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 512 13 5 5 2.6 CC(C)C[C@H](NC(=O)Cc1cccs1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL96822 215918 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NS(C)(=O)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10426645 163073 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1C 10.1021/jm00008a013
CHEMBL417651 163073 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1C 10.1021/jm00008a013
44291602 101178 None 0 Human Binding pIC50 = 6.3 6.3 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 515 8 2 10 3.6 COC(=O)c1cc(OC)cc(OC)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm9608366
CHEMBL295632 101178 None 0 Human Binding pIC50 = 6.3 6.3 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 515 8 2 10 3.6 COC(=O)c1cc(OC)cc(OC)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm9608366
44279409 99857 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 555 11 5 4 4.0 CC(C)C[C@H](NC(=O)N1CCCCCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL285782 99857 None 0 Pig Binding pIC50 = 7.3 7.3 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 555 11 5 4 4.0 CC(C)C[C@H](NC(=O)N1CCCCCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
23445533 60410 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 454 6 1 5 5.0 Cc1ccc(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL175045 60410 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 454 6 1 5 5.0 Cc1ccc(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
18617354 205475 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80507 205475 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1Br 10.1016/0960-894X(96)00441-6
23445445 102658 None 0 Human Binding pIC50 = 6.3 6.3 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 377 5 2 6 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1C 10.1016/S0960-894X(97)00367-3
CHEMBL304481 102658 None 0 Human Binding pIC50 = 6.3 6.3 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 377 5 2 6 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1C 10.1016/S0960-894X(97)00367-3
127034917 136533 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 654 12 2 8 6.2 CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736507 136533 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 654 12 2 8 6.2 CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44266628 4763 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 417 5 1 6 4.7 COc1cccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OC)cc23)c1 10.1016/0960-894X(96)00170-9
CHEMBL10388 4763 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 417 5 1 6 4.7 COc1cccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OC)cc23)c1 10.1016/0960-894X(96)00170-9
127035545 136367 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 721 14 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3734955 136367 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 721 14 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
11797486 12041 None 1 Human Binding pIC50 = 7.3 7.3 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 442 6 2 8 3.5 Cc1noc(NS(=O)(=O)c2ccsc2C(O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
CHEMBL1183448 12041 None 1 Human Binding pIC50 = 7.3 7.3 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 442 6 2 8 3.5 Cc1noc(NS(=O)(=O)c2ccsc2C(O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
CHEMBL297557 12041 None 1 Human Binding pIC50 = 7.3 7.3 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 442 6 2 8 3.5 Cc1noc(NS(=O)(=O)c2ccsc2C(O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
44279325 111623 None 0 Pig Binding pIC50 = 6.3 6.3 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 501 12 6 4 2.5 CC(C)C[C@H](NC(=O)NCC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL32845 111623 None 0 Pig Binding pIC50 = 6.3 6.3 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 501 12 6 4 2.5 CC(C)C[C@H](NC(=O)NCC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
76326542 85340 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 504 7 1 6 5.2 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccccc21 10.1007/s00044-004-0021-y
CHEMBL2261356 85340 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 504 7 1 6 5.2 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccccc21 10.1007/s00044-004-0021-y
10337624 100096 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3ccc(N(C)C)cc23)c1C 10.1021/jm00008a013
CHEMBL287451 100096 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3ccc(N(C)C)cc23)c1C 10.1021/jm00008a013
15340616 106832 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 420 4 1 6 3.3 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccc2c(c1)OCO2 10.1016/s0960-894x(00)00232-8
CHEMBL3144602 106832 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 420 4 1 6 3.3 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccc2c(c1)OCO2 10.1016/s0960-894x(00)00232-8
10337624 100096 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3ccc(N(C)C)cc23)c1C 10.1021/jm00004a012
CHEMBL287451 100096 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3ccc(N(C)C)cc23)c1C 10.1021/jm00004a012
CHEMBL137011 208741 None 0 Pig Binding pIC50 = 5.3 5.3 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC2CCCCC2)NC1=O 10.1021/jm00021a021
127034757 136393 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 679 12 2 7 7.5 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735265 136393 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 679 12 2 7 7.5 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10185233 60060 None 0 Human Binding pIC50 = 6.3 6.3 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 497 8 2 8 3.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL173721 60060 None 0 Human Binding pIC50 = 6.3 6.3 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 497 8 2 8 3.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCC#CCO 10.1016/s0960-894x(02)01084-3
44279145 110542 None 0 Pig Binding pIC50 = 7.2 7.2 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 515 13 5 4 3.0 CC(C)C[C@H](NC(=O)N(C(C)C)C(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL32518 110542 None 0 Pig Binding pIC50 = 7.2 7.2 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 515 13 5 4 3.0 CC(C)C[C@H](NC(=O)N(C(C)C)C(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44295097 14761 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 604 13 1 9 7.0 COc1ccc(C(=O)/C(Cc2cc(OC(C)C)c(OC(C)C)c(OC(C)C)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1206461 14761 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 604 13 1 9 7.0 COc1ccc(C(=O)/C(Cc2cc(OC(C)C)c(OC(C)C)c(OC(C)C)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL276362 14761 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 604 13 1 9 7.0 COc1ccc(C(=O)/C(Cc2cc(OC(C)C)c(OC(C)C)c(OC(C)C)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
10621170 11238 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 402 5 2 8 3.0 Cc1cc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)no1 10.1021/jm9608366
CHEMBL1178890 11238 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 402 5 2 8 3.0 Cc1cc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)no1 10.1021/jm9608366
CHEMBL48120 11238 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 402 5 2 8 3.0 Cc1cc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)no1 10.1021/jm9608366
CHEMBL149091 208784 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
10549815 61612 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 416 8 1 4 5.0 COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc(C)cc2)cc1 10.1021/jm031041j
CHEMBL177123 61612 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 416 8 1 4 5.0 COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc(C)cc2)cc1 10.1021/jm031041j
10047521 8628 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 6 1 5 4.4 COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
CHEMBL10951 8628 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 6 1 5 4.4 COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
10815883 59582 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 522 9 5 4 4.3 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL171855 59582 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 522 9 5 4 4.3 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
10815883 59582 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 522 9 5 4 4.3 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL171855 59582 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 522 9 5 4 4.3 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
10043017 99279 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 342 4 1 4 4.3 C=C(C)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00029a001
CHEMBL281942 99279 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 342 4 1 4 4.3 C=C(C)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00029a001
10043017 99279 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 342 4 1 4 4.3 C=C(C)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL281942 99279 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 342 4 1 4 4.3 C=C(C)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
234762 100001 None 31 Rat Binding pIC50 = 4.2 4.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 256 3 2 6 0.9 Nc1ccc(S(=O)(=O)Nc2nncs2)cc1 10.1021/jm00008a013
CHEMBL286737 100001 None 31 Rat Binding pIC50 = 4.2 4.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 256 3 2 6 0.9 Nc1ccc(S(=O)(=O)Nc2nncs2)cc1 10.1021/jm00008a013
44332807 107233 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 447 5 0 5 6.0 O=C(OCc1ccccc1)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL316792 107233 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 447 5 0 5 6.0 O=C(OCc1ccccc1)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
10649086 175251 None 0 Human Binding pIC50 = 6.2 6.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 500 5 3 8 4.0 Cc1noc(NS(=O)(=O)c2ccsc2NC(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
CHEMBL45723 175251 None 0 Human Binding pIC50 = 6.2 6.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 500 5 3 8 4.0 Cc1noc(NS(=O)(=O)c2ccsc2NC(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
18995998 162389 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 523 9 1 9 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL416570 162389 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 523 9 1 9 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
44293631 167801 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 463 7 2 7 4.1 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL430572 167801 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 463 7 2 7 4.1 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL328942 211314 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
44265858 167590 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 509 12 1 6 4.1 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(N)=O)C1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL430084 167590 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 509 12 1 6 4.1 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(N)=O)C1c1ccc(OC)cc1 10.1021/jm9505369
44386144 61982 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 555 9 3 7 5.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)n2ccc3ccccc32)nc1C(=O)O 10.1021/jm950592+
CHEMBL177431 61982 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 555 9 3 7 5.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)n2ccc3ccccc32)nc1C(=O)O 10.1021/jm950592+
23445336 60174 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 6 1 5 5.3 Cc1cc(C)c(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL173977 60174 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 6 1 5 5.3 Cc1cc(C)c(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL2370070 209777 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL216082 209315 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10426645 163073 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL417651 163073 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1C 10.1016/0960-894X(96)00441-6
44279333 106218 None 0 Pig Binding pIC50 = 6.2 6.2 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 513 11 5 4 2.6 CC(C)C[C@H](NC(=O)N1CCC(C)CC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31388 106218 None 0 Pig Binding pIC50 = 6.2 6.2 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 513 11 5 4 2.6 CC(C)C[C@H](NC(=O)N1CCC(C)CC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44294580 14633 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 502 8 1 7 5.8 COc1ccc(C(=O)/C(Cc2ccc(OC(C)(C)C)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1205104 14633 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 502 8 1 7 5.8 COc1ccc(C(=O)/C(Cc2ccc(OC(C)(C)C)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL52338 14633 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 502 8 1 7 5.8 COc1ccc(C(=O)/C(Cc2ccc(OC(C)(C)C)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
127034916 136398 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 668 12 2 8 6.6 CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735302 136398 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 668 12 2 8 6.6 CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL432091 213630 None 0 Rat Binding pIC50 = 4.2 4.2 - 0
Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
44384723 130885 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 563 13 2 10 3.0 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL368528 130885 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 563 13 2 10 3.0 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9853025 59815 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 690 14 2 13 3.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL172759 59815 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 690 14 2 13 3.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
44320212 106998 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 520 9 2 7 4.7 O=C(O)COc1ccccc1Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
CHEMBL315280 106998 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 520 9 2 7 4.7 O=C(O)COc1ccccc1Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
44386161 61274 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 573 9 1 9 5.6 CCC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL176650 61274 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 573 9 1 9 5.6 CCC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
18996000 99350 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 491 9 1 7 6.1 CCCOc1ccc2c(Sc3cccc(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 10.1016/0960-894X(96)00232-6
CHEMBL282398 99350 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 491 9 1 7 6.1 CCCOc1ccc2c(Sc3cccc(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 10.1016/0960-894X(96)00232-6
10476492 169190 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 407 6 2 5 4.9 Cc1noc(NS(=O)(=O)c2cccc3c(NCc4ccccc4)cccc23)c1C 10.1021/jm00008a013
CHEMBL440653 169190 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 407 6 2 5 4.9 Cc1noc(NS(=O)(=O)c2cccc3c(NCc4ccccc4)cccc23)c1C 10.1021/jm00008a013
CHEMBL343379 211697 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibitory effect against Human Endothelin A receptorInhibitory effect against Human Endothelin A receptor
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
15453209 205129 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 358 3 1 4 3.5 Cc1cc(C)c(S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/0960-894X(96)00441-6
CHEMBL77962 205129 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 358 3 1 4 3.5 Cc1cc(C)c(S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/0960-894X(96)00441-6
19347988 98882 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Compound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptorCompound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptor
ChEMBL 316 4 1 4 4.8 COc1cccc(Sc2c(C(=O)O)sc3ccccc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL27911 98882 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Compound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptorCompound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptor
ChEMBL 316 4 1 4 4.8 COc1cccc(Sc2c(C(=O)O)sc3ccccc23)c1 10.1016/0960-894X(96)00232-6
10289348 9311 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 516 16 1 5 5.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(CCC)CCC 10.1021/jm980217s
CHEMBL111023 9311 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 516 16 1 5 5.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(CCC)CCC 10.1021/jm980217s
44215416 175078 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 649 11 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccnc(-c3noc(=S)[nH]3)c2)nc1OCC1CCCO1 10.1016/j.bmcl.2016.06.014
CHEMBL4568468 175078 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 649 11 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccnc(-c3noc(=S)[nH]3)c2)nc1OCC1CCCO1 10.1016/j.bmcl.2016.06.014
44212539 204091 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 671 12 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
CHEMBL70203 204091 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 671 12 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
10739431 59578 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 394 7 1 5 4.4 N#Cc1ccc(OCc2ccncc2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
CHEMBL171844 59578 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 394 7 1 5 4.4 N#Cc1ccc(OCc2ccncc2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
10740501 60280 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 414 7 1 6 4.8 Cc1ccccc1C(Oc1cc(OCc2ccc3ncoc3c2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL174235 60280 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 414 7 1 6 4.8 Cc1ccccc1C(Oc1cc(OCc2ccc3ncoc3c2)ccc1C#N)C(=O)O 10.1021/jm990378b
11799541 181267 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 499 8 3 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CCCO)OCO3)c1Cl 10.1021/jm9608366
CHEMBL47620 181267 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 499 8 3 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CCCO)OCO3)c1Cl 10.1021/jm9608366
44212539 204091 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 671 12 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70203 204091 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 671 12 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44311135 204188 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 607 11 2 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70800 204188 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 607 11 2 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44293720 182484 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 551 11 2 9 3.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL47868 182484 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 551 11 2 9 3.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10554539 101241 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 543 9 2 11 3.4 CC(=O)OCCOc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
CHEMBL296129 101241 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 543 9 2 11 3.4 CC(=O)OCCOc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
137647152 157648 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 581 10 2 9 4.8 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4081426 157648 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 581 10 2 9 4.8 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
10429404 104876 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 372 5 1 4 3.7 CCc1ccc(CC)c(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
CHEMBL311138 104876 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 372 5 1 4 3.7 CCc1ccc(CC)c(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
44320315 107055 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 496 7 2 7 5.0 O=C(O)c1cccc(Cn2nc(-c3cccs3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00513-8
CHEMBL315638 107055 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 496 7 2 7 5.0 O=C(O)c1cccc(Cn2nc(-c3cccs3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00513-8
11006147 12426 None 0 Pig Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 550 11 2 10 4.7 COc1cccc(Oc2c(NCCOc3ncccn3)ncnc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1 10.1021/jm0102304
CHEMBL1185931 12426 None 0 Pig Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 550 11 2 10 4.7 COc1cccc(Oc2c(NCCOc3ncccn3)ncnc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1 10.1021/jm0102304
CHEMBL442031 12426 None 0 Pig Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 550 11 2 10 4.7 COc1cccc(Oc2c(NCCOc3ncccn3)ncnc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1 10.1021/jm0102304
2809510 129304 None 5 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cellsInhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cells
ChEMBL 362 5 1 7 2.8 COC(=O)c1cc(S(=O)(=O)Nc2cccc(-c3cnco3)c2)oc1C 10.1021/jm031041j
CHEMBL367093 129304 None 5 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cellsInhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cells
ChEMBL 362 5 1 7 2.8 COC(=O)c1cc(S(=O)(=O)Nc2cccc(-c3cnco3)c2)oc1C 10.1021/jm031041j
10531650 168259 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 600 11 1 7 5.0 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(Cl)cc1 10.1021/jm970101g
CHEMBL433842 168259 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 600 11 1 7 5.0 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(Cl)cc1 10.1021/jm970101g
10918533 102841 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 536 8 1 6 6.8 CC(C)Oc1ccc2c(c1)C(c1ccc(OCc3ccccc3)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL305577 102841 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 536 8 1 6 6.8 CC(C)Oc1ccc2c(c1)C(c1ccc(OCc3ccccc3)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
52949155 18409 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 557 10 2 7 5.4 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271640 18409 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 557 10 2 7 5.4 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
44315008 102829 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 665 13 5 5 4.7 CCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL305524 102829 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 665 13 5 5 4.7 CCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
44458604 98611 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 559 6 2 7 3.7 Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL276982 98611 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 559 6 2 7 3.7 Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
10239569 14786 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 534 9 1 10 4.4 COc1cc(C/C(C(=O)c2ccc3c(c2)OCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL1206715 14786 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 534 9 1 10 4.4 COc1cc(C/C(C(=O)c2ccc3c(c2)OCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL299328 14786 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 534 9 1 10 4.4 COc1cc(C/C(C(=O)c2ccc3c(c2)OCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
52943105 18477 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 529 9 2 7 4.7 CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1272190 18477 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 529 9 2 7 4.7 CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
52943105 18477 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 529 9 2 7 4.7 CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1272190 18477 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 529 9 2 7 4.7 CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
10137382 182182 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 427 5 3 7 3.8 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(O)c1 10.1021/jm9608366
CHEMBL47827 182182 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 427 5 3 7 3.8 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(O)c1 10.1021/jm9608366
10527706 96999 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 8 1 6 3.1 CCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL266594 96999 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 8 1 6 3.1 CCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10671037 131442 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL273660 131442 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL369085 131442 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm031041j
10503525 5865 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL10794 5865 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
44314609 204746 None 0 Pig Binding pIC50 = 8.2 8.2 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 720 12 6 4 5.6 CC(C)CC(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)N[C@H](Cc1c(Br)[nH]c2ccccc12)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm9600914
CHEMBL74471 204746 None 0 Pig Binding pIC50 = 8.2 8.2 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 720 12 6 4 5.6 CC(C)CC(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)N[C@H](Cc1c(Br)[nH]c2ccccc12)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm9600914
71460535 81683 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 693 15 1 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)CCCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163711 81683 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 693 15 1 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)CCCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
11826259 202903 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 437 8 1 7 4.5 CC(C)Oc1ccc2c(c1)C(OCCCC#N)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL62759 202903 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 437 8 1 7 4.5 CC(C)Oc1ccc2c(c1)C(OCCCC#N)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
71455139 82001 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 556 11 2 8 3.6 O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccccc1 10.1021/jm3009103
CHEMBL2165331 82001 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 556 11 2 8 3.6 O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccccc1 10.1021/jm3009103
10697883 11237 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 548 8 3 10 2.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CNS(C)(=O)=O)OCO3)c1Cl 10.1021/jm9608366
CHEMBL1178885 11237 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 548 8 3 10 2.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CNS(C)(=O)=O)OCO3)c1Cl 10.1021/jm9608366
CHEMBL47828 11237 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 548 8 3 10 2.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CNS(C)(=O)=O)OCO3)c1Cl 10.1021/jm9608366
21979601 81998 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 602 13 2 10 3.7 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)ncnc1OCCOc1ncc(Br)cn1 10.1016/j.bmcl.2016.06.014
CHEMBL2165328 81998 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 602 13 2 10 3.7 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)ncnc1OCCOc1ncc(Br)cn1 10.1016/j.bmcl.2016.06.014
71462248 81701 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 676 17 2 12 3.8 COCCOc1nc(NS(=O)(=O)NCc2ccccc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 10.1021/jm3009103
CHEMBL2163728 81701 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 676 17 2 12 3.8 COCCOc1nc(NS(=O)(=O)NCc2ccccc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 10.1021/jm3009103
21979601 81998 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 602 13 2 10 3.7 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)ncnc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2165328 81998 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 602 13 2 10 3.7 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)ncnc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
10360201 95684 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1onc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL25816 95684 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1onc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00008a013
9974857 97392 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 5 2 5 3.7 CCNc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL26978 97392 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 5 2 5 3.7 CCNc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL1788127 211114 None 8 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL313760 211114 None 8 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
10506868 63255 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.7 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL179138 63255 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.7 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
44266594 4199 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 491 8 1 8 4.8 COc1ccc(-c2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)cc1OC 10.1016/0960-894X(96)00170-9
CHEMBL10019 4199 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 491 8 1 8 4.8 COc1ccc(-c2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)cc1OC 10.1016/0960-894X(96)00170-9
44266646 98563 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 475 6 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00170-9
CHEMBL276638 98563 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 475 6 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00170-9
10577879 9267 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 520 9 0 9 4.5 COc1ccc(C2(OC)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
CHEMBL11082 9267 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 520 9 0 9 4.5 COc1ccc(C2(OC)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
345351 9357 None 4 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 386 4 1 5 3.8 O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL11131 9357 None 4 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 386 4 1 5 3.8 O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
10763444 111645 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 399 7 1 5 5.0 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1ccccc1F 10.1021/jm970847e
CHEMBL328580 111645 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 399 7 1 5 5.0 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1ccccc1F 10.1021/jm970847e
10597928 112763 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 414 6 1 3 5.9 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1Br)CO 10.1021/jm970847e
CHEMBL330543 112763 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 414 6 1 3 5.9 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1Br)CO 10.1021/jm970847e
10690863 206861 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 375 7 1 4 4.8 O=C(O)/C(=C/c1cc(OCc2ccccc2)ccc1[N+](=O)[O-])c1ccccc1 10.1021/jm970847e
CHEMBL90666 206861 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 375 7 1 4 4.8 O=C(O)/C(=C/c1cc(OCc2ccccc2)ccc1[N+](=O)[O-])c1ccccc1 10.1021/jm970847e
44277263 106835 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 440 5 1 5 4.2 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3cc4c(cc3Cl)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144605 106835 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 440 5 1 5 4.2 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3cc4c(cc3Cl)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
10403526 101883 None 1 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cc(N)ccc3c2)c1C 10.1021/jm00004a012
CHEMBL30075 101883 None 1 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cc(N)ccc3c2)c1C 10.1021/jm00004a012
44270522 45804 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 744 15 1 10 8.2 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccc(CC(C)C)s1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL15310 45804 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 744 15 1 10 8.2 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccc(CC(C)C)s1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
44368390 45304 None 0 Pig Binding pIC50 = 5.2 5.2 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 475 9 2 6 3.9 COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccc(O)cc2)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
CHEMBL152654 45304 None 0 Pig Binding pIC50 = 5.2 5.2 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 475 9 2 6 3.9 COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccc(O)cc2)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
14673588 4405 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Compound was evaluated for binding affinity against rabbit Endothelin A receptorCompound was evaluated for binding affinity against rabbit Endothelin A receptor
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00170-9
CHEMBL10143 4405 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Compound was evaluated for binding affinity against rabbit Endothelin A receptorCompound was evaluated for binding affinity against rabbit Endothelin A receptor
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00170-9
14673588 4405 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Compound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptorCompound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptor
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00232-6
CHEMBL10143 4405 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Compound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptorCompound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptor
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00232-6
10735178 207199 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 330 6 1 2 4.9 O=C(O)/C(=C/c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
CHEMBL92607 207199 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 330 6 1 2 4.9 O=C(O)/C(=C/c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
22998396 100812 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2ccsc2-c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL293232 100812 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2ccsc2-c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
22998396 100812 None 0 Human Binding pIC50 = 6.2 6.2 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2ccsc2-c2ccccc2)c1Br 10.1016/S0960-894X(97)00367-3
CHEMBL293232 100812 None 0 Human Binding pIC50 = 6.2 6.2 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2ccsc2-c2ccccc2)c1Br 10.1016/S0960-894X(97)00367-3
10685758 203108 None 2 Human Binding pIC50 = 5.2 5.2 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 302 4 2 6 1.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1C 10.1016/S0960-894X(97)00367-3
CHEMBL64006 203108 None 2 Human Binding pIC50 = 5.2 5.2 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 302 4 2 6 1.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1C 10.1016/S0960-894X(97)00367-3
192311 107272 None 4 Pig Binding pIC50 = 7.2 7.2 - 1
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 513 11 5 4 2.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31702 107272 None 4 Pig Binding pIC50 = 7.2 7.2 - 1
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 513 11 5 4 2.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
10627805 16577 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 630 7 2 6 5.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(Br)cccc2Br)cc1 10.1021/jm990170q
CHEMBL123926 16577 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 630 7 2 6 5.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(Br)cccc2Br)cc1 10.1021/jm990170q
22467231 98289 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 515 6 1 7 4.5 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C#N)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL274758 98289 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 515 6 1 7 4.5 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C#N)ccc23)cc1 10.1016/s0960-894x(01)00660-6
52943235 18115 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 571 12 2 7 5.9 CCCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1269101 18115 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 571 12 2 7 5.9 CCCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
44332803 4705 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 335 3 0 5 3.6 COC(=O)C(c1ccc2c(c1)OCO2)c1cc(C)nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL103497 4705 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 335 3 0 5 3.6 COC(=O)C(c1ccc2c(c1)OCO2)c1cc(C)nc2ccccc12 10.1016/S0960-894X(96)00551-3
22998414 203014 None 0 Human Binding pIC50 = 5.2 5.2 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 422 5 1 9 3.1 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1C 10.1016/S0960-894X(97)00367-3
CHEMBL63290 203014 None 0 Human Binding pIC50 = 5.2 5.2 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 422 5 1 9 3.1 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1C 10.1016/S0960-894X(97)00367-3
9984393 60070 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 527 11 4 5 2.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00144-I
CHEMBL173808 60070 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 527 11 4 5 2.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00144-I
18617345 105202 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL311461 105202 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)c1Br 10.1016/0960-894X(96)00441-6
10918216 202840 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 508 7 1 6 6.0 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OCc4ccccc4)cc32)cc1 10.1021/jm010382z
CHEMBL62450 202840 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 508 7 1 6 6.0 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OCc4ccccc4)cc32)cc1 10.1021/jm010382z
10576889 11234 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 6 3 7 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cccc(C(=O)O)c2)c1Br 10.1021/jm9608366
CHEMBL1178864 11234 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 6 3 7 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cccc(C(=O)O)c2)c1Br 10.1021/jm9608366
CHEMBL47008 11234 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 6 3 7 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cccc(C(=O)O)c2)c1Br 10.1021/jm9608366
23445457 129022 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 470 6 1 6 5.1 Cc1cc(C)c(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
CHEMBL367024 129022 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 470 6 1 6 5.1 Cc1cc(C)c(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
23445304 131344 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 484 6 1 7 4.4 Cc1cc2c(cc1CCc1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
CHEMBL368780 131344 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 484 6 1 7 4.4 Cc1cc2c(cc1CCc1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
CHEMBL407771 212680 None 0 Pig Binding pIC50 = 7.2 7.2 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CCCC[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
18995989 100553 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 583 9 1 9 6.6 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 10.1016/0960-894X(96)00232-6
CHEMBL29147 100553 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 583 9 1 9 6.6 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 10.1016/0960-894X(96)00232-6
10711546 205474 None 7 Human Binding pIC50 = 6.2 6.2 - 1
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2ccccc2Br)c1C 10.1016/0960-894X(96)00441-6
CHEMBL80506 205474 None 7 Human Binding pIC50 = 6.2 6.2 - 1
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2ccccc2Br)c1C 10.1016/0960-894X(96)00441-6
44279360 106588 None 0 Pig Binding pIC50 = 6.2 6.2 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 498 13 5 4 2.9 CC(C)C[C@H](NC(=O)CC1CCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31426 106588 None 0 Pig Binding pIC50 = 6.2 6.2 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 498 13 5 4 2.9 CC(C)C[C@H](NC(=O)CC1CCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
10602475 60368 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 537 9 3 6 4.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL174658 60368 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 537 9 3 6 4.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
44327585 161781 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 992 26 9 8 5.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1CCCCC1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL414082 161781 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 992 26 9 8 5.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1CCCCC1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL2304017 209471 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL None None None CSC(C)(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(C#N)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O 10.1021/jm9600914
44298324 195867 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 448 7 2 7 4.4 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CO)c1 10.1016/s0960-894x(00)00366-8
CHEMBL55876 195867 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 448 7 2 7 4.4 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CO)c1 10.1016/s0960-894x(00)00366-8
23445457 129022 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 470 6 1 6 5.1 Cc1cc(C)c(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL367024 129022 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 470 6 1 6 5.1 Cc1cc(C)c(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
44383537 59247 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 388 4 2 5 3.4 C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 10.1016/s0960-894x(00)00136-0
CHEMBL170335 59247 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 388 4 2 5 3.4 C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 10.1016/s0960-894x(00)00136-0
127036867 137380 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 614 11 3 8 5.7 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753134 137380 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 614 11 3 8 5.7 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
9896468 170667 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 703 13 2 10 6.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCC(=O)Nc1ccccc1C(C)C 10.1016/j.bmcl.2016.06.014
CHEMBL4451582 170667 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 703 13 2 10 6.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCC(=O)Nc1ccccc1C(C)C 10.1016/j.bmcl.2016.06.014
10646616 203764 None 3 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 436 5 1 6 3.3 COc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL6800 203764 None 3 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 436 5 1 6 3.3 COc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
10555208 12403 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 578 9 2 6 5.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2C)cc1 10.1021/jm990171i
CHEMBL1185774 12403 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 578 9 2 6 5.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2C)cc1 10.1021/jm990171i
CHEMBL432227 12403 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 578 9 2 6 5.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2C)cc1 10.1021/jm990171i
10740507 129042 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 414 7 1 4 4.9 CCc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL367032 129042 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 414 7 1 4 4.9 CCc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
10693110 98296 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 414 5 1 5 4.4 CCc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL274805 98296 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 414 5 1 5 4.4 CCc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
11733215 203134 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 459 6 1 6 4.6 COc1ccc(C2=C(C(N)=O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL64127 203134 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 459 6 1 6 4.6 COc1ccc(C2=C(C(N)=O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
44298409 194996 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 490 10 2 7 5.2 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCCO)c1 10.1016/s0960-894x(00)00366-8
CHEMBL54770 194996 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 490 10 2 7 5.2 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCCO)c1 10.1016/s0960-894x(00)00366-8
44383771 59846 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 371 7 1 6 4.5 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccsc1 10.1021/jm990378b
CHEMBL172879 59846 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 371 7 1 6 4.5 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccsc1 10.1021/jm990378b
10717923 98691 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 439 5 2 6 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL277595 98691 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 439 5 2 6 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1016/S0960-894X(97)00133-9
10550094 203079 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 420 4 1 5 3.6 Cc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL6382 203079 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 420 4 1 5 3.6 Cc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
10740138 204088 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Br)nc3)cccc12 10.1021/jm9604585
CHEMBL7019 204088 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Br)nc3)cccc12 10.1021/jm9604585
44327890 141410 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 985 26 9 8 5.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL384052 141410 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 985 26 9 8 5.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44298304 101553 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 503 10 2 7 4.7 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(N)=O)c1 10.1016/s0960-894x(00)00366-8
CHEMBL298395 101553 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 503 10 2 7 4.7 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(N)=O)c1 10.1016/s0960-894x(00)00366-8
10496523 203279 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 328 4 1 5 2.5 CN(C)c1cccc2c(S(=O)(=O)Nc3ncccn3)cccc12 10.1021/jm9604585
CHEMBL6468 203279 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 328 4 1 5 2.5 CN(C)c1cccc2c(S(=O)(=O)Nc3ncccn3)cccc12 10.1021/jm9604585
17869231 14624 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 548 11 1 9 5.5 COc1cc(C/C(C(=O)c2ccc(OC(C)C)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL1205061 14624 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 548 11 1 9 5.5 COc1cc(C/C(C(=O)c2ccc(OC(C)C)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL48315 14624 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 548 11 1 9 5.5 COc1cc(C/C(C(=O)c2ccc(OC(C)C)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
9853077 59625 None 0 Human Binding pIC50 = 7.2 7.2 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 696 13 2 12 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL172030 59625 None 0 Human Binding pIC50 = 7.2 7.2 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 696 13 2 12 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL1791008 208912 None 0 Pig Binding pIC50 = 7.2 7.2 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC[C@@H](C)[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
44327238 107405 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 8 1 8 3.1 CCCc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL318017 107405 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 8 1 8 3.1 CCCc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
44277036 170215 None 0 Rat Binding pIC50 = 4.2 4.2 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 492 10 1 7 4.5 COc1cccc(Cn2nc(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2OCCCC(=O)O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL444545 170215 None 0 Rat Binding pIC50 = 4.2 4.2 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 492 10 1 7 4.5 COc1cccc(Cn2nc(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2OCCCC(=O)O)c1 10.1016/s0960-894x(00)00232-8
44294712 14790 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 566 11 1 9 5.6 COc1cc(C/C(C(=O)c2ccc(OC(C)C)c(F)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL1206722 14790 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 566 11 1 9 5.6 COc1cc(C/C(C(=O)c2ccc(OC(C)C)c(F)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL300201 14790 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 566 11 1 9 5.6 COc1cc(C/C(C(=O)c2ccc(OC(C)C)c(F)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
11071689 9459 None 0 Pig Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 549 11 1 8 5.8 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccccc2)c1 10.1021/jm0102304
CHEMBL111876 9459 None 0 Pig Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 549 11 1 8 5.8 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccccc2)c1 10.1021/jm0102304
23445468 11230 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 459 5 3 9 2.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(O)nn2)c1Br 10.1021/jm9608366
CHEMBL1178818 11230 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 459 5 3 9 2.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(O)nn2)c1Br 10.1021/jm9608366
CHEMBL44615 11230 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 459 5 3 9 2.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(O)nn2)c1Br 10.1021/jm9608366
CHEMBL263295 210563 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
44279677 102224 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 478 2 2 3 4.0 O=C1c2cc(Br)ccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(Br)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL30297 102224 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 478 2 2 3 4.0 O=C1c2cc(Br)ccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(Br)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL147908 208779 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
23445412 102260 None 0 Human Binding pIC50 = 6.2 6.2 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 426 5 1 7 4.3 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1016/S0960-894X(97)00367-3
CHEMBL303203 102260 None 0 Human Binding pIC50 = 6.2 6.2 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 426 5 1 7 4.3 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1016/S0960-894X(97)00367-3
44385942 61374 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2C)nc1C(=O)O 10.1021/jm950592+
CHEMBL176913 61374 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2C)nc1C(=O)O 10.1021/jm950592+
10449431 100032 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 332 4 1 5 3.3 COc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00029a001
CHEMBL28692 100032 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 332 4 1 5 3.3 COc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00029a001
44276828 96770 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 324 5 3 6 1.0 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)CN)cc2)c1C 10.1021/jm00008a013
CHEMBL26470 96770 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 324 5 3 6 1.0 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)CN)cc2)c1C 10.1021/jm00008a013
10449431 100032 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 332 4 1 5 3.3 COc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL28692 100032 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 332 4 1 5 3.3 COc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL436884 213688 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
44383537 59247 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Tested for binding affinity towards rabbit Endothelin A receptorTested for binding affinity towards rabbit Endothelin A receptor
ChEMBL 388 4 2 5 3.4 C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 10.1016/s0960-894x(00)00136-0
CHEMBL170335 59247 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Tested for binding affinity towards rabbit Endothelin A receptorTested for binding affinity towards rabbit Endothelin A receptor
ChEMBL 388 4 2 5 3.4 C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 10.1016/s0960-894x(00)00136-0
6450144 122559 None 8 Rat Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at endothelin A receptor in Wistar rat thoracic aorta strips assessed as inhibition of ET1-induced vasoconstriction preincubated for 5 mins followed by ET1 additionAntagonist activity at endothelin A receptor in Wistar rat thoracic aorta strips assessed as inhibition of ET1-induced vasoconstriction preincubated for 5 mins followed by ET1 addition
ChEMBL 632 5 3 6 8.1 CC1(C)CC[C@]2(C(=O)O)CC[C@]3(COC(=O)/C=C/c4ccc(O)c(O)c4)C(=CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 10.1016/j.bmc.2015.06.055
CHEMBL3601500 122559 None 8 Rat Binding pIC50 = 7.2 7.2 - 0
Antagonist activity at endothelin A receptor in Wistar rat thoracic aorta strips assessed as inhibition of ET1-induced vasoconstriction preincubated for 5 mins followed by ET1 additionAntagonist activity at endothelin A receptor in Wistar rat thoracic aorta strips assessed as inhibition of ET1-induced vasoconstriction preincubated for 5 mins followed by ET1 addition
ChEMBL 632 5 3 6 8.1 CC1(C)CC[C@]2(C(=O)O)CC[C@]3(COC(=O)/C=C/c4ccc(O)c(O)c4)C(=CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 10.1016/j.bmc.2015.06.055
11728313 163273 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 368 6 1 5 4.2 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
CHEMBL418667 163273 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 368 6 1 5 4.2 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
CHEMBL2304008 209462 None 0 Pig Binding pIC50 = 7.2 7.2 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None CSC(C)(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O 10.1021/jm9600914
19363918 14634 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 474 7 1 8 4.4 COc1ccc(C(=O)/C(Cc2ccc3c(c2)OCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1205106 14634 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 474 7 1 8 4.4 COc1ccc(C(=O)/C(Cc2ccc3c(c2)OCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL52535 14634 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 474 7 1 8 4.4 COc1ccc(C(=O)/C(Cc2ccc3c(c2)OCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
44293927 102016 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 507 9 1 8 4.4 CCOc1ccc2c(c1)[C@@H](c1cc(OC)c(OC)c(OC)c1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL301723 102016 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 507 9 1 8 4.4 CCOc1ccc2c(c1)[C@@H](c1cc(OC)c(OC)c(OC)c1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
135884434 130563 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 628 10 2 12 5.2 C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL368117 130563 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 628 10 2 12 5.2 C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
44386535 131363 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2cccc(F)c2)nc1C(=O)O 10.1021/jm950592+
CHEMBL368853 131363 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2cccc(F)c2)nc1C(=O)O 10.1021/jm950592+
10403526 101883 None 1 Rat Binding pIC50 = 6.2 6.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cc(N)ccc3c2)c1C 10.1021/jm00008a013
CHEMBL30075 101883 None 1 Rat Binding pIC50 = 6.2 6.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cc(N)ccc3c2)c1C 10.1021/jm00008a013
10815902 166209 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 523 10 5 5 4.6 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL426589 166209 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 523 10 5 5 4.6 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
44332578 4313 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 413 3 0 5 5.6 CC(C)(C)OC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100874 4313 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 413 3 0 5 5.6 CC(C)(C)OC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL431874 213626 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00070a001
44279251 100059 None 0 Pig Binding pIC50 = 5.2 5.2 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 486 12 5 4 2.8 CC(C)C[C@H](NC(=O)CC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL287141 100059 None 0 Pig Binding pIC50 = 5.2 5.2 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 486 12 5 4 2.8 CC(C)C[C@H](NC(=O)CC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
10265127 96834 None 2 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL26522 96834 None 2 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL3301647 211327 None 0 Pig Binding pIC50 = 5.2 5.2 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10880982 102764 None 0 Rat Binding pIC50 = 4.2 4.2 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 296 2 1 4 3.0 O=C(O)C1=Cc2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm031041j
CHEMBL305149 102764 None 0 Rat Binding pIC50 = 4.2 4.2 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 296 2 1 4 3.0 O=C(O)C1=Cc2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm031041j
10880982 102764 None 0 Rat Binding pIC50 = 4.2 4.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 296 2 1 4 3.0 O=C(O)C1=Cc2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
CHEMBL305149 102764 None 0 Rat Binding pIC50 = 4.2 4.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 296 2 1 4 3.0 O=C(O)C1=Cc2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
CHEMBL385492 212350 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
10737416 59722 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 363 7 1 5 4.2 Cc1ccccc1C(Oc1cc(OCc2ccoc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL172412 59722 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 363 7 1 5 4.2 Cc1ccccc1C(Oc1cc(OCc2ccoc2)ccc1C#N)C(=O)O 10.1021/jm990378b
44293526 101355 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 563 11 2 8 4.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(C)(C)C(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL296974 101355 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 563 11 2 8 4.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(C)(C)C(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10336018 102106 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 318 3 2 5 3.0 Cc1noc(NS(=O)(=O)c2cccc3c(O)cccc23)c1C 10.1021/jm00004a012
CHEMBL30228 102106 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 318 3 2 5 3.0 Cc1noc(NS(=O)(=O)c2cccc3c(O)cccc23)c1C 10.1021/jm00004a012
22998438 203077 None 0 Human Binding pIC50 = 6.2 6.2 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 456 5 1 7 4.1 Cc1ccccc1OC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(97)00367-3
CHEMBL63805 203077 None 0 Human Binding pIC50 = 6.2 6.2 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 456 5 1 7 4.1 Cc1ccccc1OC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(97)00367-3
10602451 61751 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 536 11 3 6 5.1 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)CC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL177179 61751 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 536 11 3 6 5.1 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)CC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
1011 3350 None 29 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 609 12 3 10 4.8 OC[C@H](COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)OC)O 10.1016/j.bmcl.2016.06.014
5312146 3350 None 29 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 609 12 3 10 4.8 OC[C@H](COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)OC)O 10.1016/j.bmcl.2016.06.014
CHEMBL1628620 3350 None 29 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 609 12 3 10 4.8 OC[C@H](COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)OC)O 10.1016/j.bmcl.2016.06.014
10531851 59750 None 0 Rat Binding pIC50 = 4.2 4.2 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 614 11 3 7 5.3 CC(C)C[C@H](NC(=O)N1CCCCCC1)c1nc(C(=O)N[C@H](Cc2ccccn2)C(=O)O)c(Cc2cn(C)c3ccccc23)o1 10.1021/jm950591h
CHEMBL172506 59750 None 0 Rat Binding pIC50 = 4.2 4.2 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 614 11 3 7 5.3 CC(C)C[C@H](NC(=O)N1CCCCCC1)c1nc(C(=O)N[C@H](Cc2ccccn2)C(=O)O)c(Cc2cn(C)c3ccccc23)o1 10.1021/jm950591h
10529715 207148 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)CC(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9228 207148 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)CC(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10694547 207073 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 443 10 1 7 2.9 COCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9183 207073 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 443 10 1 7 2.9 COCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10836835 97099 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 440 7 2 5 3.8 CCCCNC(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL267483 97099 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 440 7 2 5 3.8 CCCCNC(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10599453 207270 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 445 9 1 6 5.2 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N 10.1021/jm9707131
CHEMBL93097 207270 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 445 9 1 6 5.2 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N 10.1021/jm9707131
5340 168728 None 106 Rat Binding pIC50 = 4.2 4.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 10.1021/jm00008a013
CHEMBL437 168728 None 106 Rat Binding pIC50 = 4.2 4.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 10.1021/jm00008a013
5340 168728 None 106 Human Binding pIC50 = 4.2 4.2 - 0
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 10.1021/jm030480f
CHEMBL437 168728 None 106 Human Binding pIC50 = 4.2 4.2 - 0
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 10.1021/jm030480f
18995991 100298 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 537 8 1 10 5.0 COc1cc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc(OC)c1OC 10.1016/0960-894X(96)00232-6
CHEMBL28920 100298 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 537 8 1 10 5.0 COc1cc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc(OC)c1OC 10.1016/0960-894X(96)00232-6
10649585 109771 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 518 14 1 7 3.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCC1OCCO1 10.1021/jm980217s
CHEMBL323175 109771 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 518 14 1 7 3.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCC1OCCO1 10.1021/jm980217s
22574723 15936 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 549 11 2 7 5.2 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 10.1039/C4MD00499J
CHEMBL12233 15936 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 549 11 2 7 5.2 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 10.1039/C4MD00499J
20747575 98422 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 579 12 2 8 5.0 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 10.1039/C4MD00499J
CHEMBL275545 98422 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 579 12 2 8 5.0 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 10.1039/C4MD00499J
71455064 81694 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 694 14 1 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)N(C)Cc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163721 81694 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 694 14 1 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)N(C)Cc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
10693270 60067 None 1 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL172144 60067 None 1 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL173792 60067 None 1 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
10601191 112802 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 492 11 3 6 5.7 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1cc(C(=O)O)[nH]n1 10.1021/jm9707131
CHEMBL330679 112802 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 492 11 3 6 5.7 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1cc(C(=O)O)[nH]n1 10.1021/jm9707131
22010244 206799 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm9707131
CHEMBL90320 206799 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm9707131
10740214 207302 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 408 9 1 6 4.9 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2cnsc2)ccc1C#N 10.1021/jm9707131
CHEMBL93331 207302 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 408 9 1 6 4.9 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2cnsc2)ccc1C#N 10.1021/jm9707131
10190108 130696 None 0 Human Binding pIC50 = 8.2 8.2 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 681 12 2 12 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL368386 130696 None 0 Human Binding pIC50 = 8.2 8.2 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 681 12 2 12 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
44333887 108623 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 446 7 2 6 3.9 CCNCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL320631 108623 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 446 7 2 6 3.9 CCNCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
44311528 204140 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 633 12 2 10 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70487 204140 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 633 12 2 10 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44311284 204243 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 635 12 2 10 6.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL71070 204243 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 635 12 2 10 6.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
137642741 158237 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 553 9 2 9 4.2 CCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4088349 158237 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 553 9 2 9 4.2 CCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
10224228 179610 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 424 6 1 6 4.5 Cc1ccc(C)c(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 10.1021/jm9700068
CHEMBL47424 179610 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 424 6 1 6 4.5 Cc1ccc(C)c(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 10.1021/jm9700068
101039204 158925 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 610 7 6 6 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1016/j.bmcl.2017.04.049
CHEMBL4095638 158925 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 610 7 6 6 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1016/j.bmcl.2017.04.049
11742628 98233 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 5 1 6 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL274383 98233 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 5 1 6 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
9845967 11091 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL10801 11091 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL1178000 11091 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL51530 11091 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1016/S0960-894X(97)00002-4
52944276 18427 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 559 11 3 8 4.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCCCO)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271807 18427 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 559 11 3 8 4.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCCCO)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
9845967 11091 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL10801 11091 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1178000 11091 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL51530 11091 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1016/s0960-894x(98)00301-1
104865 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
3494 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
392 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
CHEMBL957 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
DB00559 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
10790686 5248 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 474 5 1 8 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3c(c2)OCCO3)cc1 10.1021/jm9606507
CHEMBL10635 5248 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 474 5 1 8 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3c(c2)OCCO3)cc1 10.1021/jm9606507
44458999 168226 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 525 6 2 7 3.3 Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL433619 168226 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 525 6 2 7 3.3 Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
104865 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(01)00682-5
3494 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(01)00682-5
392 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(01)00682-5
CHEMBL957 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(01)00682-5
DB00559 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(01)00682-5
104865 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
3494 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
392 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
CHEMBL957 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
DB00559 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
44385593 129472 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 530 10 5 5 4.5 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2)nc1C(=O)O 10.1021/jm950592+
CHEMBL367208 129472 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 530 10 5 5 4.5 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2)nc1C(=O)O 10.1021/jm950592+
10553316 97074 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 11 1 6 4.3 CCCCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL267279 97074 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 11 1 6 4.3 CCCCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
44439108 167112 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 1267 53 3 22 5.7 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 10.1016/j.bmcl.2006.10.009
CHEMBL429019 167112 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 1267 53 3 22 5.7 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 10.1016/j.bmcl.2006.10.009
71451527 81678 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 641 15 1 12 4.8 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C2CC2)cn1 10.1021/jm3009103
CHEMBL2163706 81678 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 641 15 1 12 4.8 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C2CC2)cn1 10.1021/jm3009103
71462246 81689 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 604 12 2 12 2.6 CNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
CHEMBL2163717 81689 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 604 12 2 12 2.6 CNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
10667000 97170 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 372 5 1 6 2.8 COc1nc(C)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL268174 97170 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 372 5 1 6 2.8 COc1nc(C)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
10765171 7893 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc(OC)c(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL10901 7893 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc(OC)c(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
11798228 98494 None 2 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 461 6 1 8 3.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc([N+](=O)[O-])c2)cc1 10.1021/jm9606507
CHEMBL276018 98494 None 2 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 461 6 1 8 3.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc([N+](=O)[O-])c2)cc1 10.1021/jm9606507
9863916 60279 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 365 7 1 5 4.4 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1 10.1021/jm990378b
CHEMBL174229 60279 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 365 7 1 5 4.4 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1 10.1021/jm990378b
44320432 206253 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 442 6 1 7 3.6 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1OCCO1 10.1016/s0960-894x(00)00513-8
CHEMBL86821 206253 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 442 6 1 7 3.6 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1OCCO1 10.1016/s0960-894x(00)00513-8
CHEMBL433893 213646 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
9980487 5268 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 436 6 1 5 4.8 COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
CHEMBL10648 5268 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 436 6 1 5 4.8 COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
10692351 9392 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 400 5 0 5 4.7 COc1ccc(C2OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL11152 9392 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 400 5 0 5 4.7 COc1ccc(C2OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
10894688 203504 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 402 4 1 5 4.4 COc1cccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)c1 10.1021/jm010382z
CHEMBL66246 203504 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 402 4 1 5 4.4 COc1cccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)c1 10.1021/jm010382z
10835638 111554 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 414 6 1 3 5.7 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1Br)c1ccccc1 10.1021/jm970847e
CHEMBL328057 111554 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 414 6 1 3 5.7 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1Br)c1ccccc1 10.1021/jm970847e
10739089 111626 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 389 8 1 4 5.6 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/CCC(=O)O)c1ccccc1 10.1021/jm970847e
CHEMBL328464 111626 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 389 8 1 4 5.6 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/CCC(=O)O)c1ccccc1 10.1021/jm970847e
CHEMBL1793933 208929 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm970161m
19010490 53533 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 648 13 1 9 6.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)C(C)C)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL16018 53533 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 648 13 1 9 6.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)C(C)C)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL85341 215886 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
127029203 137425 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 628 12 3 8 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753458 137425 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 628 12 3 8 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
18617322 205458 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 350 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2ccccc2Cl)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80438 205458 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 350 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2ccccc2Cl)c1Br 10.1016/0960-894X(96)00441-6
44371531 164863 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 467 6 1 5 6.3 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3C(C)C)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL422002 164863 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 467 6 1 5 6.3 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3C(C)C)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL438768 213794 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL2370247 209811 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]([C@@H](C)CC)NC1=O 10.1021/jm00015a003
127026040 137477 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 591 11 3 8 4.6 CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753888 137477 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 591 11 3 8 4.6 CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
44298597 100835 None 0 Rat Binding pIC50 = 4.2 4.2 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 343 5 2 5 3.0 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1Cc1ccccc1 10.1016/s0960-894x(00)00366-8
CHEMBL293376 100835 None 0 Rat Binding pIC50 = 4.2 4.2 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 343 5 2 5 3.0 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1Cc1ccccc1 10.1016/s0960-894x(00)00366-8
18617333 105525 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 424 4 1 5 3.3 COc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL312187 105525 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 424 4 1 5 3.3 COc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
44459247 88021 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 575 8 1 7 4.9 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)N(C)C)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL23444 88021 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 575 8 1 7 4.9 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)N(C)C)cc21 10.1016/s0960-894x(01)00660-6
44385127 61366 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Tested for the inhibitory activity of cloned human ETA receptor by using I-ET-1 as radioligand in a competitive radioligand assayTested for the inhibitory activity of cloned human ETA receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 482 5 1 7 4.8 Cc1cc2c(cc1/C=C/c1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
CHEMBL176854 61366 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Tested for the inhibitory activity of cloned human ETA receptor by using I-ET-1 as radioligand in a competitive radioligand assayTested for the inhibitory activity of cloned human ETA receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 482 5 1 7 4.8 Cc1cc2c(cc1/C=C/c1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
44316994 204948 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 266 3 1 4 2.4 Cc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
CHEMBL76420 204948 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 266 3 1 4 2.4 Cc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
127036866 137267 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 614 11 3 8 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752117 137267 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 614 11 3 8 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
18184256 129481 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 662 13 2 13 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL367275 129481 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 662 13 2 13 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
71458720 81682 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 665 13 1 12 4.7 COc1ccccc1Oc1c(NS(=O)(=O)Cc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163710 81682 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 665 13 1 12 4.7 COc1ccccc1Oc1c(NS(=O)(=O)Cc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
44384652 61283 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 582 8 1 9 5.2 Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2cc3c(cc2COC2CCOCC2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
CHEMBL176675 61283 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 582 8 1 9 5.2 Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2cc3c(cc2COC2CCOCC2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
CHEMBL353605 211725 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL None None None CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NC(C)(C)C(=O)O 10.1016/0960-894X(95)00144-I
10672060 9258 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 470 10 1 6 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)c(OC)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL110794 9258 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 470 10 1 6 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)c(OC)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10626501 128521 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 550 10 5 4 5.1 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C(C)C)[nH]1 10.1021/jm950591h
CHEMBL366745 128521 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 550 10 5 4 5.1 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C(C)C)[nH]1 10.1021/jm950591h
10721386 60373 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 11 5 5 4.8 CCn1cc(C[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)c2nc(C(=O)O)c(C)[nH]2)c2ccccc21 10.1021/jm950592+
CHEMBL174686 60373 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 11 5 5 4.8 CCn1cc(C[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)c2nc(C(=O)O)c(C)[nH]2)c2ccccc21 10.1021/jm950592+
10603414 61063 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 585 10 4 5 5.9 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(-c2ccccc2)o1 10.1021/jm950591h
CHEMBL176420 61063 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 585 10 4 5 5.9 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(-c2ccccc2)o1 10.1021/jm950591h
71455061 81671 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 511 11 1 12 2.4 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1021/jm3009103
CHEMBL2163699 81671 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 511 11 1 12 2.4 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1021/jm3009103
11826173 202818 None 1 Rat Binding pIC50 = 7.1 7.1 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 432 5 1 6 4.5 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC)cc32)cc1 10.1021/jm031041j
CHEMBL62363 202818 None 1 Rat Binding pIC50 = 7.1 7.1 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 432 5 1 6 4.5 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC)cc32)cc1 10.1021/jm031041j
11826173 202818 None 1 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 432 5 1 6 4.5 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC)cc32)cc1 10.1021/jm010382z
CHEMBL62363 202818 None 1 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 432 5 1 6 4.5 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC)cc32)cc1 10.1021/jm010382z
44385490 131806 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 532 10 4 7 4.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccn2)nc1C(=O)O 10.1021/jm950592+
CHEMBL369386 131806 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 532 10 4 7 4.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccn2)nc1C(=O)O 10.1021/jm950592+
10833686 203403 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 380 4 1 7 2.4 COC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(97)00367-3
CHEMBL65531 203403 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 380 4 1 7 2.4 COC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(97)00367-3
44266621 98560 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 387 4 1 5 4.7 COc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(-c3ccccc3)c2c1 10.1016/0960-894X(96)00170-9
CHEMBL276615 98560 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 387 4 1 5 4.7 COc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(-c3ccccc3)c2c1 10.1016/0960-894X(96)00170-9
10722389 12123 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 606 10 2 6 6.0 CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1C 10.1021/jm990171i
CHEMBL1184099 12123 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 606 10 2 6 6.0 CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1C 10.1021/jm990171i
CHEMBL332424 12123 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 606 10 2 6 6.0 CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1C 10.1021/jm990171i
10621704 59991 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 414 7 1 6 4.8 Cc1ccccc1C(Oc1cc(OCc2ccc3ocnc3c2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL173444 59991 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 414 7 1 6 4.8 Cc1ccccc1C(Oc1cc(OCc2ccc3ocnc3c2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL151361 208791 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
44270498 98922 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 702 13 1 10 7.2 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(CC(C)C)s1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL279419 98922 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 702 13 1 10 7.2 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(CC(C)C)s1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
10577941 61356 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 522 10 6 4 4.3 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL176794 61356 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 522 10 6 4 4.3 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL2370070 209777 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
44276596 106840 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 458 8 1 6 4.2 COc1ccc(Cc2[nH]n(Cc3cccc(OC)c3)c(=O)c2Cc2ccc3c(c2)OCO3)cc1 10.1016/s0960-894x(00)00232-8
CHEMBL3144728 106840 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 458 8 1 6 4.2 COc1ccc(Cc2[nH]n(Cc3cccc(OC)c3)c(=O)c2Cc2ccc3c(c2)OCO3)cc1 10.1016/s0960-894x(00)00232-8
10477792 173802 None 2 Human Binding pIC50 = 4.1 4.1 - 0
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cellsDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells
ChEMBL 430 8 0 7 3.7 COC[C@@H]1Cc2cc3c(c(OC)c2[C@H](c2ccc(OC)c(OC)c2)[C@H]1COC)OCO3 10.1021/np50124a006
CHEMBL453822 173802 None 2 Human Binding pIC50 = 4.1 4.1 - 0
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cellsDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells
ChEMBL 430 8 0 7 3.7 COC[C@@H]1Cc2cc3c(c(OC)c2[C@H](c2ccc(OC)c(OC)c2)[C@H]1COC)OCO3 10.1021/np50124a006
10305181 60447 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 666 11 2 12 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)NC1CCCCC1 10.1016/s0960-894x(02)01084-3
CHEMBL175278 60447 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 666 11 2 12 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)NC1CCCCC1 10.1016/s0960-894x(02)01084-3
10578300 129988 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 537 10 4 6 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)OC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL367645 129988 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 537 10 4 6 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)OC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
44279126 100725 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 466 3 2 3 5.5 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(Cl)cc3Cl)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL29265 100725 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 466 3 2 3 5.5 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(Cl)cc3Cl)cc21 10.1016/0960-894X(95)00230-Q
44284490 100224 None 0 Pig Binding pIC50 = 5.1 5.1 - 0
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 616 13 3 5 3.9 CNC(=O)[C@H](Cc1ccccn1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)N(C)C(=O)[C@@H](CC(=O)N1CCCCCC1)CC(C)C 10.1021/jm00087a001
CHEMBL288514 100224 None 0 Pig Binding pIC50 = 5.1 5.1 - 0
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 616 13 3 5 3.9 CNC(=O)[C@H](Cc1ccccn1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)N(C)C(=O)[C@@H](CC(=O)N1CCCCCC1)CC(C)C 10.1021/jm00087a001
CHEMBL1206620 208605 None 0 Pig Binding pIC50 = 5.1 5.1 - 0
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL None None None CC(C)C[C@@H](NC(=O)N1CCCCCC1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccn1)C(=O)N(C)CC(=O)O 10.1021/jm00087a001
CHEMBL287980 208605 None 0 Pig Binding pIC50 = 5.1 5.1 - 0
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL None None None CC(C)C[C@@H](NC(=O)N1CCCCCC1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccn1)C(=O)N(C)CC(=O)O 10.1021/jm00087a001
44332641 4738 None 0 Human Binding pIC50 = 4.1 4.1 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 384 4 0 4 5.2 COC(=O)C(Cc1c2ccccc2cc2ccccc12)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00551-3
CHEMBL103731 4738 None 0 Human Binding pIC50 = 4.1 4.1 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 384 4 0 4 5.2 COC(=O)C(Cc1c2ccccc2cc2ccccc12)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00551-3
10598270 96942 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 421 6 1 5 4.1 CCCC#CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL266144 96942 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 421 6 1 5 4.1 CCCC#CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10744041 97300 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 502 8 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)Cc2ccccc2)cc1 10.1021/jm9505369
CHEMBL269108 97300 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 502 8 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)Cc2ccccc2)cc1 10.1021/jm9505369
11101703 167916 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 412 7 1 5 5.3 CCCC[C@@H]1c2cc(OC(C)C)ccc2O[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1021/jm031041j
CHEMBL431372 167916 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 412 7 1 5 5.3 CCCC[C@@H]1c2cc(OC(C)C)ccc2O[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1021/jm031041j
11101703 167916 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 7 1 5 5.3 CCCC[C@@H]1c2cc(OC(C)C)ccc2O[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1021/jm010382z
CHEMBL431372 167916 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 7 1 5 5.3 CCCC[C@@H]1c2cc(OC(C)C)ccc2O[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1021/jm010382z
44293736 188149 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 463 7 2 7 4.1 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL49850 188149 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 463 7 2 7 4.1 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL147058 208775 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
9874557 129736 None 0 Human Binding pIC50 = 7.1 7.1 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 667 15 2 10 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL367443 129736 None 0 Human Binding pIC50 = 7.1 7.1 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 667 15 2 10 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
10516176 205198 None 3 Human Binding pIC50 = 6.1 6.1 - 1
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccccc2F)c1C 10.1016/0960-894X(96)00441-6
CHEMBL78499 205198 None 3 Human Binding pIC50 = 6.1 6.1 - 1
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccccc2F)c1C 10.1016/0960-894X(96)00441-6
44298278 194665 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 462 8 2 7 4.5 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCO)c1 10.1016/s0960-894x(00)00366-8
CHEMBL53168 194665 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 462 8 2 7 4.5 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCO)c1 10.1016/s0960-894x(00)00366-8
10626522 130281 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 551 11 4 5 5.2 CCCc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL367989 130281 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 551 11 4 5 5.2 CCCc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
9961347 11960 None 1 Human Binding pIC50 = 4.1 4.1 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 664 13 2 7 6.6 Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C 10.1021/jm990171i
CHEMBL1182945 11960 None 1 Human Binding pIC50 = 4.1 4.1 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 664 13 2 7 6.6 Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C 10.1021/jm990171i
CHEMBL273642 11960 None 1 Human Binding pIC50 = 4.1 4.1 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 664 13 2 7 6.6 Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C 10.1021/jm990171i
137638953 156845 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 579 10 2 9 4.6 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4071505 156845 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 579 10 2 9 4.6 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
11728411 202879 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 372 3 1 4 4.4 O=C(O)C1=C(c2ccccc2)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm031041j
CHEMBL62659 202879 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 372 3 1 4 4.4 O=C(O)C1=C(c2ccccc2)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm031041j
5344 173471 None 101 Human Binding pIC50 = 6.1 6.1 - 1
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00029a001
CHEMBL453 173471 None 101 Human Binding pIC50 = 6.1 6.1 - 1
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00029a001
5344 173471 None 101 Rat Binding pIC50 = 6.1 6.1 - 1
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00008a013
CHEMBL453 173471 None 101 Rat Binding pIC50 = 6.1 6.1 - 1
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00008a013
11728411 202879 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 372 3 1 4 4.4 O=C(O)C1=C(c2ccccc2)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
CHEMBL62659 202879 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 372 3 1 4 4.4 O=C(O)C1=C(c2ccccc2)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
5344 173471 None 101 Human Binding pIC50 = 6.1 6.1 - 1
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm030480f
CHEMBL453 173471 None 101 Human Binding pIC50 = 6.1 6.1 - 1
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm030480f
10334781 96008 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1C 10.1021/jm00008a013
CHEMBL25970 96008 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1C 10.1021/jm00008a013
9983872 101721 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 511 9 2 5 6.9 Cc1noc(NS(=O)(=O)c2cccc3c(NCCC(c4ccccc4)c4ccccc4)cccc23)c1C 10.1021/jm00008a013
CHEMBL29954 101721 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 511 9 2 5 6.9 Cc1noc(NS(=O)(=O)c2cccc3c(NCCC(c4ccccc4)c4ccccc4)cccc23)c1C 10.1021/jm00008a013
10336018 102106 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 318 3 2 5 3.0 Cc1noc(NS(=O)(=O)c2cccc3c(O)cccc23)c1C 10.1021/jm00008a013
CHEMBL30228 102106 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 318 3 2 5 3.0 Cc1noc(NS(=O)(=O)c2cccc3c(O)cccc23)c1C 10.1021/jm00008a013
CHEMBL413825 213085 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptorBinding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor
ChEMBL None None None C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)NC(=O)[C@H]2CCCN2C1=O 10.1016/0960-894X(95)00084-7
10840422 131364 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 550 11 5 4 4.9 CCCc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL368854 131364 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 550 11 5 4 4.9 CCCc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
10624915 206231 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 490 6 2 6 4.5 COc1ccc(NC(=O)N2C[C@@H](c3ccc4c(c3)OCO4)[C@H](C(=O)O)[C@H]2c2ccc(OC)cc2)cc1 10.1021/jm9505369
CHEMBL8671 206231 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 490 6 2 6 4.5 COc1ccc(NC(=O)N2C[C@@H](c3ccc4c(c3)OCO4)[C@H](C(=O)O)[C@H]2c2ccc(OC)cc2)cc1 10.1021/jm9505369
18617288 205144 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 316 3 1 4 2.5 Cc1noc(NS(=O)(=O)c2ccccc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL78080 205144 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 316 3 1 4 2.5 Cc1noc(NS(=O)(=O)c2ccccc2)c1Br 10.1016/0960-894X(96)00441-6
44320444 206441 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 481 7 2 8 4.0 O=C(O)c1cc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)on1 10.1016/s0960-894x(00)00513-8
CHEMBL88019 206441 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 481 7 2 8 4.0 O=C(O)c1cc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)on1 10.1016/s0960-894x(00)00513-8
CHEMBL146866 208774 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
44384651 128497 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 498 6 2 8 4.0 Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2cc3c(cc2CO)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
CHEMBL366680 128497 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 498 6 2 8 4.0 Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2cc3c(cc2CO)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
44332624 4179 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 356 3 1 4 3.7 NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100120 4179 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 356 3 1 4 3.7 NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
10743872 97205 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 13 1 6 5.2 CCCCN(CCCC)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL268432 97205 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 13 1 6 5.2 CCCCN(CCCC)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
3847484 203731 None 3 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 360 4 1 3 4.4 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)cc3)cccc12 10.1021/jm9604585
CHEMBL6778 203731 None 3 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 360 4 1 3 4.4 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)cc3)cccc12 10.1021/jm9604585
10145418 81670 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 601 14 1 12 4.0 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1016/j.bmcl.2016.06.014
CHEMBL2163698 81670 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 601 14 1 12 4.0 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1016/j.bmcl.2016.06.014
CHEMBL354082 211727 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL None None None CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)N[C@H](CO)C(=O)O 10.1016/0960-894X(95)00144-I
CHEMBL354152 211728 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL None None None CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)O 10.1016/0960-894X(95)00144-I
10646372 5450 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 5 2 7 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(O)cc2)cc1 10.1021/jm9606507
CHEMBL10744 5450 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 5 2 7 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(O)cc2)cc1 10.1021/jm9606507
10950392 202952 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 448 5 1 5 5.4 CC(C)Oc1ccc2c(c1)C(c1ccc(F)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL62966 202952 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 448 5 1 5 5.4 CC(C)Oc1ccc2c(c1)C(c1ccc(F)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
11113542 203208 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 8 1 6 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3OC)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL64398 203208 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 8 1 6 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3OC)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
44314575 103570 None 0 Pig Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 601 13 5 5 4.2 CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL308584 103570 None 0 Pig Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 601 13 5 5 4.2 CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
22010244 206799 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm970847e
CHEMBL90320 206799 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm970847e
44439106 153605 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 1005 37 2 17 5.8 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 10.1016/j.bmcl.2006.10.009
CHEMBL398070 153605 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 1005 37 2 17 5.8 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 10.1016/j.bmcl.2006.10.009
10145418 81670 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 601 14 1 12 4.0 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1021/jm3009103
CHEMBL2163698 81670 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 601 14 1 12 4.0 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1021/jm3009103
44304492 96558 None 0 Pig Binding pIC50 = 8.1 8.1 - 0
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL262993 96558 None 0 Pig Binding pIC50 = 8.1 8.1 - 0
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL265614 210654 None 19 Pig Binding pIC50 = 8.1 8.1 - 0
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
104865 705 None 99 Human Binding pIC50 = 8.1 8.1 1 4
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
3494 705 None 99 Human Binding pIC50 = 8.1 8.1 1 4
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
392 705 None 99 Human Binding pIC50 = 8.1 8.1 1 4
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
CHEMBL957 705 None 99 Human Binding pIC50 = 8.1 8.1 1 4
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
DB00559 705 None 99 Human Binding pIC50 = 8.1 8.1 1 4
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
10230835 110231 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 12 1 7 4.0 CCCS(=O)(=O)N(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)CC(C)C 10.1021/jm970101g
CHEMBL323789 110231 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 12 1 7 4.0 CCCS(=O)(=O)N(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)CC(C)C 10.1021/jm970101g
10383884 205207 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 359 4 2 5 2.9 CNc1ccc(C)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL78563 205207 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 359 4 2 5 2.9 CNc1ccc(C)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
44314660 104363 None 0 Pig Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 633 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCC1C)C(=O)O 10.1021/jm9600914
CHEMBL310111 104363 None 0 Pig Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 633 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCC1C)C(=O)O 10.1021/jm9600914
CHEMBL2304011 209465 None 0 Pig Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL None None None Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O 10.1021/jm9600914
10766385 98426 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm9606507
CHEMBL275559 98426 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm9606507
44333889 5081 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 463 7 1 6 5.3 CCCSc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL105494 5081 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 463 7 1 6 5.3 CCCSc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
10647373 96969 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 8 2 6 3.0 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(C)C)cc1 10.1021/jm9505369
CHEMBL266337 96969 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 8 2 6 3.0 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(C)C)cc1 10.1021/jm9505369
10817057 9692 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 580 11 1 7 4.7 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 10.1021/jm970101g
CHEMBL113087 9692 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 580 11 1 7 4.7 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 10.1021/jm970101g
9840391 104537 None 6 Human Binding pIC50 = 8.1 8.1 - 1
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL310427 104537 None 6 Human Binding pIC50 = 8.1 8.1 - 1
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1C 10.1016/0960-894X(96)00441-6
9803428 102202 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 442 5 1 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Cl 10.1016/S0960-894X(97)00367-3
CHEMBL302872 102202 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 442 5 1 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Cl 10.1016/S0960-894X(97)00367-3
CHEMBL336033 211572 None 1 Human Binding pIC50 = 8.1 8.1 - 0
Inhibitory effect against Human Endothelin A receptorInhibitory effect against Human Endothelin A receptor
ChEMBL None None None CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
104865 705 None 99 Human Binding pIC50 = 8.1 8.1 1 4
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1039/C5MD00169B
3494 705 None 99 Human Binding pIC50 = 8.1 8.1 1 4
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1039/C5MD00169B
392 705 None 99 Human Binding pIC50 = 8.1 8.1 1 4
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1039/C5MD00169B
CHEMBL957 705 None 99 Human Binding pIC50 = 8.1 8.1 1 4
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1039/C5MD00169B
DB00559 705 None 99 Human Binding pIC50 = 8.1 8.1 1 4
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1039/C5MD00169B
10504689 9439 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 474 6 1 8 3.6 COC(=O)c1cccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)c1 10.1021/jm9606507
CHEMBL11176 9439 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 474 6 1 8 3.6 COC(=O)c1cccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)c1 10.1021/jm9606507
10840410 204058 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 550 10 2 10 3.3 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCC(=O)O)c2)cc1 10.1021/jm980504w
CHEMBL70017 204058 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 550 10 2 10 3.3 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCC(=O)O)c2)cc1 10.1021/jm980504w
CHEMBL2304006 209460 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL None None None O=C(O)C[C@H]1NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm9600914
CHEMBL411171 212865 None 0 Pig Binding pIC50 = 8.1 8.1 - 1
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00077a013
22467266 85344 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261360 85344 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
10626362 11449 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 544 8 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 10.1021/jm990171i
CHEMBL1180351 11449 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 544 8 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 10.1021/jm990171i
CHEMBL123316 11449 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 544 8 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 10.1021/jm990171i
22467230 85353 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 8 1 8 4.0 COCc1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C)cc3OC)c3ccc4c(c3)OCO4)cn(C)c2c1 10.1007/s00044-004-0021-y
CHEMBL2261601 85353 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 8 1 8 4.0 COCc1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C)cc3OC)c3ccc4c(c3)OCO4)cn(C)c2c1 10.1007/s00044-004-0021-y
11038925 9856 None 0 Pig Binding pIC50 = 8.1 8.1 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 550 11 1 9 5.2 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccccn2)c1 10.1021/jm0102304
CHEMBL114105 9856 None 0 Pig Binding pIC50 = 8.1 8.1 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 550 11 1 9 5.2 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccccn2)c1 10.1021/jm0102304
9826741 100756 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 486 5 1 9 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00367-3
CHEMBL292802 100756 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 486 5 1 9 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00367-3
9826741 100756 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 486 5 1 9 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
CHEMBL292802 100756 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 486 5 1 9 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
10068813 98026 None 8 Rat Binding pIC50 = 7.1 7.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 387 8 2 5 4.8 CCCCCNc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL27299 98026 None 8 Rat Binding pIC50 = 7.1 7.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 387 8 2 5 4.8 CCCCCNc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
104865 705 None 99 Human Binding pIC50 = 7.1 7.1 1 4
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.0c01093
3494 705 None 99 Human Binding pIC50 = 7.1 7.1 1 4
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.0c01093
392 705 None 99 Human Binding pIC50 = 7.1 7.1 1 4
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.0c01093
CHEMBL957 705 None 99 Human Binding pIC50 = 7.1 7.1 1 4
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.0c01093
DB00559 705 None 99 Human Binding pIC50 = 7.1 7.1 1 4
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.0c01093
10406285 111650 None 1 Rat Binding pIC50 = 7.1 7.1 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 361 6 1 4 4.8 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccccc1 10.1021/jm970847e
CHEMBL328600 111650 None 1 Rat Binding pIC50 = 7.1 7.1 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 361 6 1 4 4.8 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccccc1 10.1021/jm970847e
104865 705 None 99 Human Binding pIC50 = 7.1 7.1 1 4
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
3494 705 None 99 Human Binding pIC50 = 7.1 7.1 1 4
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
392 705 None 99 Human Binding pIC50 = 7.1 7.1 1 4
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
CHEMBL957 705 None 99 Human Binding pIC50 = 7.1 7.1 1 4
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
DB00559 705 None 99 Human Binding pIC50 = 7.1 7.1 1 4
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
18184229 59606 None 0 Human Binding pIC50 = 7.1 7.1 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 605 15 2 10 4.2 CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL171950 59606 None 0 Human Binding pIC50 = 7.1 7.1 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 605 15 2 10 4.2 CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
44266552 4511 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10218 4511 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
44266567 98231 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 461 5 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(-c3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00170-9
CHEMBL274368 98231 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 461 5 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(-c3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00170-9
104865 705 None 99 Human Binding pIC50 = 7.1 7.1 1 4
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
3494 705 None 99 Human Binding pIC50 = 7.1 7.1 1 4
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
392 705 None 99 Human Binding pIC50 = 7.1 7.1 1 4
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
CHEMBL957 705 None 99 Human Binding pIC50 = 7.1 7.1 1 4
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
DB00559 705 None 99 Human Binding pIC50 = 7.1 7.1 1 4
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
19432672 204219 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 606 11 3 9 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCNC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70924 204219 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 606 11 3 9 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCNC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
10623877 8486 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 461 6 1 8 3.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc([N+](=O)[O-])cc2)cc1 10.1021/jm9606507
CHEMBL10940 8486 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 461 6 1 8 3.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc([N+](=O)[O-])cc2)cc1 10.1021/jm9606507
11015023 102718 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 406 3 1 4 5.1 O=C(O)C1=C(c2ccc(Cl)cc2)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
CHEMBL304875 102718 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 406 3 1 4 5.1 O=C(O)C1=C(c2ccc(Cl)cc2)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
19095644 169710 None 0 Human Binding pIC50 = 6.1 6.1 - 1
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccccc2)nc1OCCO 10.1021/acs.jmedchem.0c01093
CHEMBL4438132 169710 None 0 Human Binding pIC50 = 6.1 6.1 - 1
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccccc2)nc1OCCO 10.1021/acs.jmedchem.0c01093
14041110 100012 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 322 2 2 3 2.5 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccccc21 10.1016/0960-894X(95)00230-Q
CHEMBL286808 100012 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 322 2 2 3 2.5 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccccc21 10.1016/0960-894X(95)00230-Q
10497859 163424 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 347 6 1 4 4.7 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/CO)c1ccccc1 10.1021/jm970847e
CHEMBL419694 163424 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 347 6 1 4 4.7 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/CO)c1ccccc1 10.1021/jm970847e
44298325 195675 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 446 7 1 6 5.5 CCc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Sc1cccc(OC)c1 10.1016/s0960-894x(00)00366-8
CHEMBL55664 195675 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 446 7 1 6 5.5 CCc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Sc1cccc(OC)c1 10.1016/s0960-894x(00)00366-8
19095644 169710 None 0 Human Binding pIC50 = 6.1 6.1 - 1
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccccc2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4438132 169710 None 0 Human Binding pIC50 = 6.1 6.1 - 1
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccccc2)nc1OCCO 10.1016/j.bmcl.2016.06.014
5344 173471 None 101 Rat Binding pIC50 = 6.1 6.1 - 1
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00004a012
CHEMBL453 173471 None 101 Rat Binding pIC50 = 6.1 6.1 - 1
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00004a012
44386621 61275 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
CHEMBL176653 61275 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
44266542 162808 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 521 7 1 7 6.1 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(OCc3ccccc3)ccc2n1Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL417246 162808 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 521 7 1 7 6.1 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(OCc3ccccc3)ccc2n1Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
44368428 44574 None 0 Pig Binding pIC50 = 5.1 5.1 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 521 9 2 5 5.5 O=C(O)C(Cc1ccc(O)cc1)N(Cc1ccccc1-c1ccccc1)C(=O)/C=C/c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00009-9
CHEMBL152001 44574 None 0 Pig Binding pIC50 = 5.1 5.1 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 521 9 2 5 5.5 O=C(O)C(Cc1ccc(O)cc1)N(Cc1ccccc1-c1ccccc1)C(=O)/C=C/c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00009-9
CHEMBL330489 211330 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00070a001
CHEMBL86737 215888 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00070a001
CHEMBL330489 211330 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/S0960-894X(01)81215-4
10627378 60421 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 598 11 5 4 5.6 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)[nH]1 10.1021/jm950591h
CHEMBL175103 60421 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 598 11 5 4 5.6 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)[nH]1 10.1021/jm950591h
18995996 99200 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 569 10 1 8 6.9 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OCc4ccccc4)cc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL281451 99200 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 569 10 1 8 6.9 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OCc4ccccc4)cc23)c1 10.1016/0960-894X(96)00232-6
44279366 99659 None 0 Pig Binding pIC50 = 7.1 7.1 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 499 11 5 4 2.4 CC(C)C[C@H](NC(=O)N1CCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL284392 99659 None 0 Pig Binding pIC50 = 7.1 7.1 - 0
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 499 11 5 4 2.4 CC(C)C[C@H](NC(=O)N1CCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44384757 166146 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 482 5 1 7 4.8 Cc1cc2c(cc1/C=C/c1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
CHEMBL426218 166146 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 482 5 1 7 4.8 Cc1cc2c(cc1/C=C/c1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
11103152 163238 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)c(OC)c1)O2 10.1021/jm010382z
CHEMBL418473 163238 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)c(OC)c1)O2 10.1021/jm010382z
44314580 205135 None 0 Pig Binding pIC50 = 6.1 6.1 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 608 13 5 5 4.5 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C(C)C)C(=O)O 10.1021/jm9600914
CHEMBL78023 205135 None 0 Pig Binding pIC50 = 6.1 6.1 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 608 13 5 5 4.5 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C(C)C)C(=O)O 10.1021/jm9600914
CHEMBL441006 213873 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptorBinding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor
ChEMBL None None None CC(=O)[C@H](Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00084-7
23445388 206522 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2sccc2-c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL88506 206522 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2sccc2-c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
9917072 62101 None 0 Human Binding pIC50 = 7.1 7.1 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 619 16 2 10 4.6 CCCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL177538 62101 None 0 Human Binding pIC50 = 7.1 7.1 - 2
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 619 16 2 10 4.6 CCCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
23445408 111633 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 454 6 1 5 5.5 Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(CC(C)C)cc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL328517 111633 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 454 6 1 5 5.5 Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(CC(C)C)cc2)c1Br 10.1016/S0960-894X(96)00496-9
44270602 98856 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 688 13 1 10 7.0 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1cccs1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL278930 98856 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 688 13 1 10 7.0 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1cccs1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
1009 194 None 25 Human Binding pIC50 = 5.1 5.1 - 1
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm990170q
5310991 194 None 25 Human Binding pIC50 = 5.1 5.1 - 1
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm990170q
CHEMBL332794 194 None 25 Human Binding pIC50 = 5.1 5.1 - 1
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm990170q
44383535 59278 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 280 4 1 5 1.5 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(OC)[C@]2(O)CC1 10.1016/s0960-894x(00)00136-0
CHEMBL170446 59278 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 280 4 1 5 1.5 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(OC)[C@]2(O)CC1 10.1016/s0960-894x(00)00136-0
10960638 101066 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 414 4 1 4 5.6 CC(C)c1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm010382z
CHEMBL294793 101066 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 414 4 1 4 5.6 CC(C)c1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm010382z
23445358 111561 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 4 1 5 4.6 Cc1cccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/S0960-894X(96)00496-9
CHEMBL328089 111561 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 4 1 5 4.6 Cc1cccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/S0960-894X(96)00496-9
10546830 101373 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 365 4 2 6 1.7 Cc1noc(NS(=O)(=O)c2ccsc2C(N)=O)c1Br 10.1021/jm9608366
CHEMBL297107 101373 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 365 4 2 6 1.7 Cc1noc(NS(=O)(=O)c2ccsc2C(N)=O)c1Br 10.1021/jm9608366
44386069 59733 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 704 13 2 11 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL172441 59733 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 704 13 2 11 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
18995999 98510 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 477 6 1 8 5.0 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)c1 10.1016/0960-894X(96)00232-6
CHEMBL27617 98510 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 477 6 1 8 5.0 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)c1 10.1016/0960-894X(96)00232-6
44384611 128652 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 644 10 2 12 5.8 C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL366797 128652 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 644 10 2 12 5.8 C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10405292 97574 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3cc(N(C)C)ccc23)c1C 10.1021/jm00008a013
CHEMBL27073 97574 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3cc(N(C)C)ccc23)c1C 10.1021/jm00008a013
44316526 205419 None 2 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 344 3 1 4 3.2 Cc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
CHEMBL80180 205419 None 2 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 344 3 1 4 3.2 Cc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
10674642 113368 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 574 10 3 7 4.7 CCc1cc(C(=O)O)cc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL331758 113368 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 574 10 3 7 4.7 CCc1cc(C(=O)O)cc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
10405292 97574 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3cc(N(C)C)ccc23)c1C 10.1021/jm00004a012
CHEMBL27073 97574 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3cc(N(C)C)ccc23)c1C 10.1021/jm00004a012
19010508 56343 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 501 9 1 7 5.5 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL16306 56343 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 501 9 1 7 5.5 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
14973488 113805 None 0 Human Binding pIC50 = 4.1 4.1 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 295 4 1 5 2.2 Cc1noc(NS(=O)(=O)c2ccc(N(C)C)cc2)c1C 10.1021/jm00029a001
CHEMBL332471 113805 None 0 Human Binding pIC50 = 4.1 4.1 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 295 4 1 5 2.2 Cc1noc(NS(=O)(=O)c2ccc(N(C)C)cc2)c1C 10.1021/jm00029a001
14973488 113805 None 0 Rat Binding pIC50 = 4.1 4.1 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 295 4 1 5 2.2 Cc1noc(NS(=O)(=O)c2ccc(N(C)C)cc2)c1C 10.1021/jm00004a012
CHEMBL332471 113805 None 0 Rat Binding pIC50 = 4.1 4.1 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 295 4 1 5 2.2 Cc1noc(NS(=O)(=O)c2ccc(N(C)C)cc2)c1C 10.1021/jm00004a012
44293685 101778 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@@H](c1cccc(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL300000 101778 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@@H](c1cccc(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10576377 12005 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 471 6 2 7 3.9 COc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1021/jm9608366
CHEMBL1183291 12005 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 471 6 2 7 3.9 COc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1021/jm9608366
CHEMBL288967 12005 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 471 6 2 7 3.9 COc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1021/jm9608366
44384715 60360 None 0 Human Binding pIC50 = 7.1 7.1 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 559 9 1 9 5.2 CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL174607 60360 None 0 Human Binding pIC50 = 7.1 7.1 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 559 9 1 9 5.2 CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
44265861 97206 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 481 11 1 6 5.1 CCCC(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL268433 97206 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 481 11 1 6 5.1 CCCC(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL433406 213638 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)NC)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
5344 173471 None 101 Human Binding pIC50 = 6.1 6.1 - 1
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL453 173471 None 101 Human Binding pIC50 = 6.1 6.1 - 1
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL308208 210981 None 0 Pig Binding pIC50 = 5.1 5.1 - 0
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm00089a028
CHEMBL341751 211658 None 0 Pig Binding pIC50 = 5.1 5.1 - 0
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCN2C1=O 10.1021/jm00021a021
10763577 59897 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 401 7 1 4 5.3 Cc1ccccc1C(Oc1cc(OCc2c(C)cccc2C)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL173054 59897 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 401 7 1 4 5.3 Cc1ccccc1C(Oc1cc(OCc2c(C)cccc2C)ccc1C#N)C(=O)O 10.1021/jm990378b
10916428 162693 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 402 4 1 5 4.4 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm031041j
CHEMBL417050 162693 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 402 4 1 5 4.4 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm031041j
15289331 99562 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 433 6 1 6 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3ccccc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL283648 99562 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 433 6 1 6 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3ccccc23)c1 10.1016/0960-894X(96)00232-6
10916428 162693 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 402 4 1 5 4.4 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm010382z
CHEMBL417050 162693 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 402 4 1 5 4.4 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm010382z
9810400 98605 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 710 14 2 12 5.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL276949 98605 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 710 14 2 12 5.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
10338501 102053 None 1 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00004a012
CHEMBL30199 102053 None 1 Rat Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00004a012
10275056 112507 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 440 6 1 5 5.2 CCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
CHEMBL329890 112507 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 440 6 1 5 5.2 CCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
9998564 99479 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cccc(S(=O)(=O)Nc3onc(C)c3C)c2c1 10.1021/jm00008a013
CHEMBL283175 99479 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cccc(S(=O)(=O)Nc3onc(C)c3C)c2c1 10.1021/jm00008a013
9998564 99479 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cccc(S(=O)(=O)Nc3onc(C)c3C)c2c1 10.1021/jm00004a012
CHEMBL283175 99479 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cccc(S(=O)(=O)Nc3onc(C)c3C)c2c1 10.1021/jm00004a012
10602312 59661 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 531 11 5 5 4.5 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NCc2ccccc2)nc1C(=O)O 10.1021/jm950592+
CHEMBL172178 59661 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 531 11 5 5 4.5 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NCc2ccccc2)nc1C(=O)O 10.1021/jm950592+
10571971 168170 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 382 9 1 4 5.6 Cc1ccccc1C(CCC(=O)O)Oc1cccc(OCc2ccsc2)c1 10.1021/jm9707131
CHEMBL433209 168170 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 382 9 1 4 5.6 Cc1ccccc1C(CCC(=O)O)Oc1cccc(OCc2ccsc2)c1 10.1021/jm9707131
137639474 156895 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 607 10 2 9 5.4 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CCCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4072165 156895 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 607 10 2 9 5.4 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CCCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
10696788 175913 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro inhibitory activity against human Endothelin A receptor using radioligand binding assay.In vitro inhibitory activity against human Endothelin A receptor using radioligand binding assay.
ChEMBL 501 5 2 9 3.9 Cc1noc(NS(=O)(=O)c2ccsc2NC(=O)Oc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
CHEMBL45872 175913 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro inhibitory activity against human Endothelin A receptor using radioligand binding assay.In vitro inhibitory activity against human Endothelin A receptor using radioligand binding assay.
ChEMBL 501 5 2 9 3.9 Cc1noc(NS(=O)(=O)c2ccsc2NC(=O)Oc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
10338501 102053 None 1 Human Binding pIC50 = 6.1 6.1 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00029a001
CHEMBL30199 102053 None 1 Human Binding pIC50 = 6.1 6.1 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00029a001
10475320 96496 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 387 5 2 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(NC(=O)C(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL26252 96496 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 387 5 2 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(NC(=O)C(C)C)cccc23)c1C 10.1021/jm00008a013
10338501 102053 None 1 Rat Binding pIC50 = 6.1 6.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL30199 102053 None 1 Rat Binding pIC50 = 6.1 6.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
56678452 63325 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@H](C)CC)C(=O)CNC(=O)[C@H](N)Cc1c[nH]c2ccccc12 10.1021/jm970161m
CHEMBL1793928 63325 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@H](C)CC)C(=O)CNC(=O)[C@H](N)Cc1c[nH]c2ccccc12 10.1021/jm970161m
44311288 204182 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 592 11 1 10 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)c1cccnc1 10.1016/S0960-894X(97)00400-9
CHEMBL70781 204182 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 592 11 1 10 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)c1cccnc1 10.1016/S0960-894X(97)00400-9
14673588 4405 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00232-6
CHEMBL10143 4405 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00232-6
14673588 4405 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Compound was evaluated for binding affinity against human Endothelin A receptorCompound was evaluated for binding affinity against human Endothelin A receptor
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00170-9
CHEMBL10143 4405 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Compound was evaluated for binding affinity against human Endothelin A receptorCompound was evaluated for binding affinity against human Endothelin A receptor
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00170-9
10790183 206243 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 461 8 1 6 4.3 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCOc2ccccc2)cc1 10.1021/jm9505369
CHEMBL8677 206243 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 461 8 1 6 4.3 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCOc2ccccc2)cc1 10.1021/jm9505369
127026058 137244 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 600 10 3 8 6.0 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3751899 137244 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 600 10 3 8 6.0 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
10839533 101443 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 513 5 2 9 2.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)NC(=O)c2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
CHEMBL297599 101443 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 513 5 2 9 2.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)NC(=O)c2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
10839947 117300 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 530 9 2 6 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL339657 117300 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 530 9 2 6 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
44320777 206203 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 550 10 2 8 4.7 COc1ccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c(OCC(=O)O)c1 10.1016/s0960-894x(00)00513-8
CHEMBL86505 206203 None 0 Rat Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 550 10 2 8 4.7 COc1ccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c(OCC(=O)O)c1 10.1016/s0960-894x(00)00513-8
10415067 45363 None 0 Pig Binding pIC50 = 5.1 5.1 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 546 8 2 6 5.0 O=C(O)C(Cc1c[nH]c2ccccc12)N(Cc1cc2c(cc1Cl)OCO2)C(=O)/C=C/c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00009-9
CHEMBL152713 45363 None 0 Pig Binding pIC50 = 5.1 5.1 - 0
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 546 8 2 6 5.0 O=C(O)C(Cc1c[nH]c2ccccc12)N(Cc1cc2c(cc1Cl)OCO2)C(=O)/C=C/c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00009-9
10449375 95767 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 331 4 1 5 3.0 Cc1cc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)on1 10.1021/jm00008a013
CHEMBL25854 95767 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 331 4 1 5 3.0 Cc1cc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)on1 10.1021/jm00008a013
CHEMBL289687 210873 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
3811690 205408 None 3 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2ccc(Br)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL80129 205408 None 3 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2ccc(Br)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL289687 210873 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00152-J
127035082 136509 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736262 136509 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
15411002 108550 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 563 9 1 10 4.2 CNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
CHEMBL320183 108550 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 563 9 1 10 4.2 CNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
44314661 103023 None 0 Pig Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 14 5 4 5.1 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CCCC)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL306977 103023 None 0 Pig Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 14 5 4 5.1 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CCCC)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
10646514 59337 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 434 7 1 6 5.1 N#Cc1ccc(OCc2ccc3ncoc3c2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
CHEMBL170681 59337 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 434 7 1 6 5.1 N#Cc1ccc(OCc2ccc3ncoc3c2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
10619391 60236 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL173251 60236 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL174092 60236 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
9931773 78362 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1[C@H](Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL2110231 78362 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1[C@H](Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
44311285 102297 None 0 Human Binding pIC50 = 8.1 8.1 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 635 13 2 10 6.4 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOC(=O)Nc2ccccn2)n1 10.1016/S0960-894X(97)00400-9
CHEMBL303428 102297 None 0 Human Binding pIC50 = 8.1 8.1 - 1
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 635 13 2 10 6.4 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOC(=O)Nc2ccccn2)n1 10.1016/S0960-894X(97)00400-9
10992620 203348 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 384 5 1 6 3.8 COC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL65070 203348 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 384 5 1 6 3.8 COC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
44314646 205037 None 0 Pig Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 633 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCCC1)C(=O)O 10.1021/jm9600914
CHEMBL77033 205037 None 0 Pig Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 633 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCCC1)C(=O)O 10.1021/jm9600914
44314889 103740 None 0 Pig Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 633 12 5 4 4.7 CCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL308815 103740 None 0 Pig Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 633 12 5 4 4.7 CCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
44314620 103143 None 0 Pig Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 587 12 5 4 4.4 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
CHEMBL307903 103143 None 0 Pig Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 587 12 5 4 4.4 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
23445404 100909 None 0 Human Binding pIC50 = 8.0 8.0 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 456 5 1 7 4.1 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00367-3
CHEMBL293877 100909 None 0 Human Binding pIC50 = 8.0 8.0 - 0
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 456 5 1 7 4.1 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00367-3
10119105 101445 None 0 Human Binding pIC50 = 8.0 8.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 526 7 2 9 3.1 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CC(=O)N(C)C)OCO3)c1Cl 10.1021/jm9608366
CHEMBL297618 101445 None 0 Human Binding pIC50 = 8.0 8.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 526 7 2 9 3.1 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CC(=O)N(C)C)OCO3)c1Cl 10.1021/jm9608366
10650062 60442 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 537 10 4 6 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL175228 60442 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 537 10 4 6 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
155517241 170156 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 522 14 2 11 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
CHEMBL4444355 170156 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 522 14 2 11 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
10129267 81686 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 617 13 1 12 3.9 CCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
CHEMBL2163714 81686 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 617 13 1 12 3.9 CCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
44314723 204996 None 0 Pig Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 583 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL76735 204996 None 0 Pig Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 583 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
44314659 205118 None 0 Pig Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 631 12 5 4 4.5 C=CCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL77853 205118 None 0 Pig Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 631 12 5 4 4.5 C=CCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
52949155 18409 None 0 Human Binding pIC50 = 8 8.0 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 557 10 2 7 5.4 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1271640 18409 None 0 Human Binding pIC50 = 8 8.0 - 0
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 557 10 2 7 5.4 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
10814318 9150 None 0 Rat Binding pIC50 = 8 8.0 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 472 14 1 5 4.7 C=CCCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL110064 9150 None 0 Rat Binding pIC50 = 8 8.0 - 0
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 472 14 1 5 4.7 C=CCCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
52944083 18416 None 0 Human Binding pIC50 = 8 8.0 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 557 10 2 7 5.5 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OC(C)CC)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271691 18416 None 0 Human Binding pIC50 = 8 8.0 - 0
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 557 10 2 7 5.5 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OC(C)CC)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
71456864 81690 None 0 Human Binding pIC50 = 8 8.0 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 618 13 2 12 3.0 CCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
CHEMBL2163718 81690 None 0 Human Binding pIC50 = 8 8.0 - 0
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 618 13 2 12 3.0 CCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
11734340 163709 None 0 Pig Binding pIC50 = 8 8.0 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 552 10 1 10 4.6 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccncc2)nc1 10.1021/jm0102304
CHEMBL420501 163709 None 0 Pig Binding pIC50 = 8 8.0 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 552 10 1 10 4.6 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccncc2)nc1 10.1021/jm0102304
10501279 98216 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 402 6 1 5 4.1 COc1ccc(C2(O)OC(=O)C(c3cccc(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL274307 98216 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 402 6 1 5 4.1 COc1ccc(C2(O)OC(=O)C(c3cccc(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
44371516 50983 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 469 7 1 6 5.6 CCOc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc(OC)cc2)c2oc3ccccc3c21 10.1016/s0960-894x(99)00040-2
CHEMBL157827 50983 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 469 7 1 6 5.6 CCOc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc(OC)cc2)c2oc3ccccc3c21 10.1016/s0960-894x(99)00040-2
CHEMBL279259 210837 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Binding affinity for Endothelin A receptor was determined in murine 3T3 cellsBinding affinity for Endothelin A receptor was determined in murine 3T3 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](N)CCCNC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(00)80326-1
11794876 207174 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 393 7 1 4 4.9 O=C(O)/C(=C/c1cc(OCc2ccccc2)ccc1[N+](=O)[O-])c1ccccc1F 10.1021/jm970847e
CHEMBL92446 207174 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 393 7 1 4 4.9 O=C(O)/C(=C/c1cc(OCc2ccccc2)ccc1[N+](=O)[O-])c1ccccc1F 10.1021/jm970847e
44213651 4296 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 343 3 1 4 4.2 OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100795 4296 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 343 3 1 4 4.2 OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
10742024 96941 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 446 7 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCc2ccccn2)cc1 10.1021/jm9505369
CHEMBL266143 96941 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 446 7 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCc2ccccn2)cc1 10.1021/jm9505369
10841134 60446 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 589 10 4 6 5.3 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC23CC4CC(CC(C4)C2)C3)nc1C(=O)O 10.1021/jm950592+
CHEMBL175277 60446 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 589 10 4 6 5.3 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC23CC4CC(CC(C4)C2)C3)nc1C(=O)O 10.1021/jm950592+
44311321 204183 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 607 11 2 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1cccnc1 10.1016/S0960-894X(97)00400-9
CHEMBL70788 204183 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 607 11 2 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1cccnc1 10.1016/S0960-894X(97)00400-9
5344 173471 None 101 Rat Binding pIC50 = 5.1 5.1 - 1
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/s0960-894x(00)00366-8
CHEMBL453 173471 None 101 Rat Binding pIC50 = 5.1 5.1 - 1
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/s0960-894x(00)00366-8
10015852 99439 None 2 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 268 3 2 5 1.8 Cc1noc(NS(=O)(=O)c2ccc(O)cc2)c1C 10.1021/jm00004a012
CHEMBL282961 99439 None 2 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 268 3 2 5 1.8 Cc1noc(NS(=O)(=O)c2ccc(O)cc2)c1C 10.1021/jm00004a012
22616255 205531 None 11 Human Binding pIC50 = 4.1 4.1 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL80945 205531 None 11 Human Binding pIC50 = 4.1 4.1 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1C 10.1016/0960-894X(96)00441-6
23445333 127804 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 484 6 1 7 4.4 Cc1cc2c(cc1CCc1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
CHEMBL366378 127804 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 484 6 1 7 4.4 Cc1cc2c(cc1CCc1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
CHEMBL313984 211121 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL317099 211196 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10792636 168513 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 10 2 6 5.4 CCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 10.1021/jm990170q
CHEMBL435385 168513 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 10 2 6 5.4 CCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 10.1021/jm990170q
CHEMBL315658 211189 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
127026042 137255 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 620 11 3 9 3.8 CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3751986 137255 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 620 11 3 9 3.8 CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL315658 211189 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
11145367 10015 None 0 Pig Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 487 10 1 8 4.4 COCCOc1ncnc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1cccc(OC)c1 10.1021/jm0102304
CHEMBL114985 10015 None 0 Pig Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 487 10 1 8 4.4 COCCOc1ncnc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1cccc(OC)c1 10.1021/jm0102304
10745418 113990 None 1 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 9 2 6 6.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C(C)C)cccc2C(C)C)cc1 10.1021/jm990170q
CHEMBL332627 113990 None 1 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 9 2 6 6.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C(C)C)cccc2C(C)C)cc1 10.1021/jm990170q
10015852 99439 None 2 Human Binding pIC50 = 5.0 5.0 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 268 3 2 5 1.8 Cc1noc(NS(=O)(=O)c2ccc(O)cc2)c1C 10.1021/jm00029a001
CHEMBL282961 99439 None 2 Human Binding pIC50 = 5.0 5.0 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 268 3 2 5 1.8 Cc1noc(NS(=O)(=O)c2ccc(O)cc2)c1C 10.1021/jm00029a001
10015852 99439 None 2 Rat Binding pIC50 = 5.0 5.0 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 268 3 2 5 1.8 Cc1noc(NS(=O)(=O)c2ccc(O)cc2)c1C 10.1021/jm00008a013
CHEMBL282961 99439 None 2 Rat Binding pIC50 = 5.0 5.0 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 268 3 2 5 1.8 Cc1noc(NS(=O)(=O)c2ccc(O)cc2)c1C 10.1021/jm00008a013
11813885 167792 None 0 Pig Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 579 12 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCCOc2ncc(C)cn2)c1 10.1021/jm0102304
CHEMBL430515 167792 None 0 Pig Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 579 12 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCCOc2ncc(C)cn2)c1 10.1021/jm0102304
CHEMBL313056 211109 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00070a001
10576217 9759 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 467 12 1 5 4.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2cccnc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL113494 9759 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 467 12 1 5 4.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2cccnc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL146155 208773 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
11798109 12357 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 457 7 2 7 4.2 COc1cccc(NCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1021/jm9608366
CHEMBL1185459 12357 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 457 7 2 7 4.2 COc1cccc(NCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1021/jm9608366
CHEMBL416086 12357 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 457 7 2 7 4.2 COc1cccc(NCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1021/jm9608366
23445544 61373 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Tested for its activity in cloned human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayTested for its activity in cloned human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 438 5 1 5 5.1 Cc1ccc(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
CHEMBL176912 61373 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Tested for its activity in cloned human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayTested for its activity in cloned human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 438 5 1 5 5.1 Cc1ccc(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
3887 2070 None 45 Human Binding pIC50 = 7.0 7.0 -436 4
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 2 hrsDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 2 hrs
ChEMBL None None None None 10.1021/acs.jmedchem.5b01781
5311192 2070 None 45 Human Binding pIC50 = 7.0 7.0 -436 4
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 2 hrsDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 2 hrs
ChEMBL None None None None 10.1021/acs.jmedchem.5b01781
CHEMBL72410 2070 None 45 Human Binding pIC50 = 7.0 7.0 -436 4
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 2 hrsDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 2 hrs
ChEMBL None None None None 10.1021/acs.jmedchem.5b01781
44386002 60294 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 503 9 1 9 3.9 C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL174326 60294 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 503 9 1 9 3.9 C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
11005242 202893 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1)O2 10.1021/jm010382z
CHEMBL62719 202893 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1)O2 10.1021/jm010382z
44293682 185684 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 447 7 1 6 4.4 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL48652 185684 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 447 7 1 6 4.4 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10553165 9738 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 492 7 1 6 5.4 O=C1OC(O)(c2ccc(OCc3ccccc3)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL11341 9738 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 492 7 1 6 5.4 O=C1OC(O)(c2ccc(OCc3ccccc3)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL414917 213158 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptorBinding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor
ChEMBL None None None NC(=O)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00084-7
CHEMBL289687 210873 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
CHEMBL289687 210873 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
127035085 136430 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 661 12 2 7 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735574 136430 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 661 12 2 7 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44293741 186959 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 447 7 1 6 4.4 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1021/jm031041j
CHEMBL49040 186959 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 447 7 1 6 4.4 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1021/jm031041j
44293868 101588 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 551 11 2 9 3.9 CCOc1ccc2c(c1)[C@H](c1ccc(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL298664 101588 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 551 11 2 9 3.9 CCOc1ccc2c(c1)[C@H](c1ccc(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
44293741 186959 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 447 7 1 6 4.4 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL49040 186959 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 447 7 1 6 4.4 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
44384766 59663 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 532 10 1 10 4.1 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL172184 59663 None 0 Human Binding pIC50 = 7.0 7.0 - 0
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 532 10 1 10 4.1 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
44385940 130670 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC(C)C2)nc1C(=O)O 10.1021/jm950592+
CHEMBL368255 130670 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC(C)C2)nc1C(=O)O 10.1021/jm950592+
44386421 60735 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 537 10 4 5 4.5 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1CC(=O)O 10.1021/jm950592+
CHEMBL176093 60735 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 537 10 4 5 4.5 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1CC(=O)O 10.1021/jm950592+
9807456 60471 None 0 Human Binding pIC50 = 7.0 7.0 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 545 9 1 9 4.8 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL175435 60471 None 0 Human Binding pIC50 = 7.0 7.0 - 1
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 545 9 1 9 4.8 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10195727 203925 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 487 7 1 8 5.6 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nsnc2c1 10.1016/s0960-894x(97)10151-2
CHEMBL69150 203925 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 487 7 1 8 5.6 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nsnc2c1 10.1016/s0960-894x(97)10151-2
10195727 203925 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 487 7 1 8 5.6 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nsnc2c1 10.1021/jm0300429
CHEMBL69150 203925 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 487 7 1 8 5.6 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nsnc2c1 10.1021/jm0300429
44279360 106588 None 0 Pig Binding pIC50 = 6.0 6.0 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 498 13 5 4 2.9 CC(C)C[C@H](NC(=O)CC1CCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31426 106588 None 0 Pig Binding pIC50 = 6.0 6.0 - 0
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 498 13 5 4 2.9 CC(C)C[C@H](NC(=O)CC1CCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
11048815 102313 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1ccc2c(c1)OC(c1ccc3c(c1)OCO3)C(C(=O)O)=C2c1ccc(OC)cc1 10.1021/jm010382z
CHEMBL303531 102313 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1ccc2c(c1)OC(c1ccc3c(c1)OCO3)C(C(=O)O)=C2c1ccc(OC)cc1 10.1021/jm010382z
10625738 169491 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 517 6 2 6 5.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(-c3ccccc3)cc2)c1Br 10.1021/jm9608366
CHEMBL44321 169491 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 517 6 2 6 5.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(-c3ccccc3)cc2)c1Br 10.1021/jm9608366
9801094 59489 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 399 7 1 5 5.1 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1cccc(Cl)c1 10.1021/jm990378b
CHEMBL171446 59489 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 399 7 1 5 5.1 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1cccc(Cl)c1 10.1021/jm990378b
CHEMBL359235 211803 None 0 Mouse Binding pIC50 = 7.0 7.0 - 0
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
44316686 103515 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 286 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccccc2Cl)c1C 10.1016/0960-894X(96)00441-6
CHEMBL308521 103515 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 286 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccccc2Cl)c1C 10.1016/0960-894X(96)00441-6
10021240 95493 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 357 6 2 5 3.7 Cc1noc(NS(=O)(=O)c2ccc(NCc3ccccc3)cc2)c1C 10.1021/jm00029a001
CHEMBL25730 95493 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 357 6 2 5 3.7 Cc1noc(NS(=O)(=O)c2ccc(NCc3ccccc3)cc2)c1C 10.1021/jm00029a001
10021240 95493 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 357 6 2 5 3.7 Cc1noc(NS(=O)(=O)c2ccc(NCc3ccccc3)cc2)c1C 10.1021/jm00008a013
CHEMBL25730 95493 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 357 6 2 5 3.7 Cc1noc(NS(=O)(=O)c2ccc(NCc3ccccc3)cc2)c1C 10.1021/jm00008a013
10087192 99581 None 1 Rat Binding pIC50 = 5.0 5.0 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cccc(N)c3c2)c1C 10.1021/jm00008a013
CHEMBL283879 99581 None 1 Rat Binding pIC50 = 5.0 5.0 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cccc(N)c3c2)c1C 10.1021/jm00008a013
10087192 99581 None 1 Rat Binding pIC50 = 5.0 5.0 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cccc(N)c3c2)c1C 10.1021/jm00004a012
CHEMBL283879 99581 None 1 Rat Binding pIC50 = 5.0 5.0 - 0
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cccc(N)c3c2)c1C 10.1021/jm00004a012
44276993 106852 None 0 Rat Binding pIC50 = 4.0 4.0 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 362 5 1 3 3.8 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccccc3)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144831 106852 None 0 Rat Binding pIC50 = 4.0 4.0 - 0
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 362 5 1 3 3.8 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccccc3)c2=O)c1 10.1016/s0960-894x(00)00232-8
5472495 186631 None 47 Human Binding pIC50 = 5.0 5.0 - 1
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 nan
CHEMBL488025 186631 None 47 Human Binding pIC50 = 5.0 5.0 - 1
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 nan
18617381 105679 None 0 Human Binding pIC50 = 6 6.0 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 300 3 1 4 3.1 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2C)c1C 10.1016/0960-894X(96)00441-6
CHEMBL312551 105679 None 0 Human Binding pIC50 = 6 6.0 - 0
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 300 3 1 4 3.1 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2C)c1C 10.1016/0960-894X(96)00441-6
15453170 104899 None 4 Human Binding pIC50 = 5 5.0 - 0
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL311258 104899 None 4 Human Binding pIC50 = 5 5.0 - 0
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c1C 10.1016/0960-894X(96)00441-6
1009 194 None 25 Human Binding pIC50 = 5 5.0 - 1
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm990170q
5310991 194 None 25 Human Binding pIC50 = 5 5.0 - 1
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm990170q
CHEMBL332794 194 None 25 Human Binding pIC50 = 5 5.0 - 1
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm990170q
44284481 213723 None 0 Rat Binding pKd = 9.8 9.8 -6 5
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL437472 213723 None 0 Rat Binding pKd = 9.8 9.8 -6 5
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL409577 212767 None 0 Rat Binding pKd = 9.5 9.5 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)
ChEMBL None None None CCCC[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC1=O 10.1016/S0960-894X(01)81085-4
CHEMBL442316 213909 None 0 Rat Binding pKd = 9.2 9.2 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
19095644 169710 None 0 Rat Binding pKd = 6.9 6.9 - 1
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccccc2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4438132 169710 None 0 Rat Binding pKd = 6.9 6.9 - 1
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccccc2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL438470 213770 None 0 Rat Binding pKd = 6.9 6.9 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](C)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL412467 212991 None 0 Rat Binding pKd = 5.9 5.9 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
19735343 176049 None 0 Rat Binding pKd = 5.8 5.8 - 1
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 473 7 2 6 4.0 O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4590568 176049 None 0 Rat Binding pKd = 5.8 5.8 - 1
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 473 7 2 6 4.0 O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL409577 212767 None 0 Rat Binding pKd = 7.8 7.8 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)
ChEMBL None None None CCCC[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC1=O 10.1016/S0960-894X(01)81085-4
CHEMBL386629 212383 None 0 Rat Binding pKd = 6.7 6.7 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
155519384 170416 None 0 Rat Binding pKd = 7.7 7.7 - 1
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 674 12 1 13 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)c1ccccn1 10.1016/j.bmcl.2016.06.014
CHEMBL4448273 170416 None 0 Rat Binding pKd = 7.7 7.7 - 1
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 674 12 1 13 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)c1ccccn1 10.1016/j.bmcl.2016.06.014
CHEMBL438027 213741 None 0 Rat Binding pKd = 5.7 5.7 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL263581 210574 None 0 Rat Binding pKd = 8.7 8.7 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/S0960-894X(01)81085-4
CHEMBL410001 212792 None 0 Rat Binding pKd = 5.5 5.5 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL412467 212991 None 0 Rat Binding pKd = 7.5 7.5 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL409171 212747 None 0 Rat Binding pKd = 5.5 5.5 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/S0960-894X(01)81085-4
104865 705 None 99 Rat Binding pKd = 7.4 7.4 -1 4
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
3494 705 None 99 Rat Binding pKd = 7.4 7.4 -1 4
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
392 705 None 99 Rat Binding pKd = 7.4 7.4 -1 4
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
CHEMBL957 705 None 99 Rat Binding pKd = 7.4 7.4 -1 4
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
DB00559 705 None 99 Rat Binding pKd = 7.4 7.4 -1 4
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
10395582 16966 None 0 Rat Binding pKd = 5.4 5.4 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL 806 8 6 13 3.2 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)Nc4ccccc4)C(C)(C)C)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C 10.1016/S0960-894X(01)81085-4
CHEMBL125377 16966 None 0 Rat Binding pKd = 5.4 5.4 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL 806 8 6 13 3.2 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)Nc4ccccc4)C(C)(C)C)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C 10.1016/S0960-894X(01)81085-4
CHEMBL414286 213118 None 0 Rat Binding pKd = 6.4 6.4 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](C)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL409578 212768 None 0 Rat Binding pKd = 5.3 5.3 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](NC(C)=O)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL412346 212982 None 0 Rat Binding pKd = 7.3 7.3 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL438027 213741 None 0 Rat Binding pKd = 8.2 8.2 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL268318 210742 None 0 Rat Binding pKd = 6.2 6.2 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL442316 213909 None 0 Rat Binding pKd = 7.1 7.1 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL414286 213118 None 0 Rat Binding pKd = 8.0 8.0 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](C)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL407887 212690 None 0 Rat Binding pKd = 6.0 6.0 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC1=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)O)CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N2 10.1016/S0960-894X(01)81085-4
10983585 173272 None 0 Rat Binding pKd = 6.0 6.0 - 1
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 473 9 2 8 3.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4525321 173272 None 0 Rat Binding pKd = 6.0 6.0 - 1
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 473 9 2 8 3.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL409171 212747 None 0 Rat Binding pKd = 7.0 7.0 - 1
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/S0960-894X(01)81085-4
44277840 98252 None 0 Human Binding pKi = 11 11.0 81283 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 522 7 1 7 5.8 Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2N(C)C(=O)CC(C)(C)C)c1C 10.1021/jm020289q
CHEMBL274489 98252 None 0 Human Binding pKi = 11 11.0 81283 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 522 7 1 7 5.8 Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2N(C)C(=O)CC(C)(C)C)c1C 10.1021/jm020289q
11071765 169205 None 0 Human Binding pKi = 11 11.0 8709 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 556 9 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)Cc2ccccc2)c1C 10.1021/jm020289q
CHEMBL440780 169205 None 0 Human Binding pKi = 11 11.0 8709 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 556 9 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)Cc2ccccc2)c1C 10.1021/jm020289q
44275660 98674 None 0 Human Binding pKi = 11 11.0 - 1
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 522 8 2 7 5.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNC(=O)CC(C)(C)C)c1C 10.1021/jm030480f
CHEMBL277447 98674 None 0 Human Binding pKi = 11 11.0 - 1
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 522 8 2 7 5.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNC(=O)CC(C)(C)C)c1C 10.1021/jm030480f
9852318 9612 None 8 Human Binding pKi = 10.8 10.8 2691 2
Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsAbility to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cells
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
CHEMBL112624 9612 None 8 Human Binding pKi = 10.8 10.8 2691 2
Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsAbility to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cells
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
CHEMBL1627022 9612 None 8 Human Binding pKi = 10.8 10.8 2691 2
Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsAbility to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cells
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
10119517 99232 None 0 Human Binding pKi = 10.7 10.7 169824 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 536 8 1 7 5.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC(C)(C)C)c1C 10.1021/jm020289q
CHEMBL281659 99232 None 0 Human Binding pKi = 10.7 10.7 169824 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 536 8 1 7 5.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC(C)(C)C)c1C 10.1021/jm020289q
11124425 99862 None 0 Human Binding pKi = 10.7 10.7 75857 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 543 7 1 8 5.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2ccc(C(F)(F)F)n2)c1C 10.1021/jm020289q
CHEMBL285832 99862 None 0 Human Binding pKi = 10.7 10.7 75857 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 543 7 1 8 5.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2ccc(C(F)(F)F)n2)c1C 10.1021/jm020289q
10918301 101494 None 0 Human Binding pKi = 10.7 10.7 7585 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 514 8 1 7 6.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)c2ccccc2)c1C 10.1021/jm020289q
CHEMBL29793 101494 None 0 Human Binding pKi = 10.7 10.7 7585 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 514 8 1 7 6.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)c2ccccc2)c1C 10.1021/jm020289q
44284481 213723 None 0 Human Binding pKi = 10.6 10.6 -4 5
Binding affinity to human ETA receptor by radioligand displacement assayBinding affinity to human ETA receptor by radioligand displacement assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/j.ejmech.2013.01.044
CHEMBL437472 213723 None 0 Human Binding pKi = 10.6 10.6 -4 5
Binding affinity to human ETA receptor by radioligand displacement assayBinding affinity to human ETA receptor by radioligand displacement assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/j.ejmech.2013.01.044
11731054 98809 None 0 Human Binding pKi = 10.5 10.5 21379 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 522 7 1 7 5.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)C(C)(C)C)c1C 10.1021/jm020289q
CHEMBL27855 98809 None 0 Human Binding pKi = 10.5 10.5 21379 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 522 7 1 7 5.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)C(C)(C)C)c1C 10.1021/jm020289q
159594 522 None 45 Rat Binding pKi = 10.5 10.5 -1 3
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
3487 522 None 45 Rat Binding pKi = 10.5 10.5 -1 3
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
CHEMBL9194 522 None 45 Rat Binding pKi = 10.5 10.5 -1 3
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
DB06199 522 None 45 Rat Binding pKi = 10.5 10.5 -1 3
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
186002 102840 None 23 Rat Binding pKi = 10.5 10.5 -1 3
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 531 10 2 6 5.4 CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1C[C@H](C)C(=O)O)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm030528p
CHEMBL305576 102840 None 23 Rat Binding pKi = 10.5 10.5 -1 3
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 531 10 2 6 5.4 CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1C[C@H](C)C(=O)O)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm030528p
44284481 213723 None 0 Rat Binding pKi = 10.5 10.5 -6 5
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
CHEMBL437472 213723 None 0 Rat Binding pKi = 10.5 10.5 -6 5
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
159594 522 None 45 Human Binding pKi = 10.5 10.5 1 3
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
3487 522 None 45 Human Binding pKi = 10.5 10.5 1 3
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
CHEMBL9194 522 None 45 Human Binding pKi = 10.5 10.5 1 3
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
DB06199 522 None 45 Human Binding pKi = 10.5 10.5 1 3
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
159594 522 None 45 Human Binding pKi = 10.5 10.5 1 3
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
3487 522 None 45 Human Binding pKi = 10.5 10.5 1 3
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
CHEMBL9194 522 None 45 Human Binding pKi = 10.5 10.5 1 3
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
DB06199 522 None 45 Human Binding pKi = 10.5 10.5 1 3
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
9936145 19025 None 2 Human Binding pKi = 10.4 10.4 - 1
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 510 11 1 4 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 10.1021/jm010237l
CHEMBL128818 19025 None 2 Human Binding pKi = 10.4 10.4 - 1
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 510 11 1 4 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 10.1021/jm010237l
44284481 213723 None 0 Pig Binding pKi = 10.4 10.4 -3 5
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
CHEMBL437472 213723 None 0 Pig Binding pKi = 10.4 10.4 -3 5
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
9958321 79149 None 0 Human Binding pKi = 10.4 10.4 19498 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 520 7 1 7 5.2 Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCC(C)(C)C2=O)c1C 10.1021/jm020289q
CHEMBL2113316 79149 None 0 Human Binding pKi = 10.4 10.4 19498 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 520 7 1 7 5.2 Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCC(C)(C)C2=O)c1C 10.1021/jm020289q
11813553 99344 None 0 Human Binding pKi = 10.4 10.4 14454 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 542 8 1 7 5.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)c2ccccc2)c1C 10.1021/jm020289q
CHEMBL282359 99344 None 0 Human Binding pKi = 10.4 10.4 14454 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 542 8 1 7 5.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)c2ccccc2)c1C 10.1021/jm020289q
11027595 100239 None 0 Human Binding pKi = 10.4 10.4 19952 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 508 8 1 7 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)C(C)C)c1C 10.1021/jm020289q
CHEMBL28863 100239 None 0 Human Binding pKi = 10.4 10.4 19952 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 508 8 1 7 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)C(C)C)c1C 10.1021/jm020289q
10918368 102521 None 0 Human Binding pKi = 10.4 10.4 21379 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 520 7 1 7 5.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CC(C)(C)CC2=O)c1C 10.1021/jm020289q
CHEMBL30405 102521 None 0 Human Binding pKi = 10.4 10.4 21379 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 520 7 1 7 5.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CC(C)(C)CC2=O)c1C 10.1021/jm020289q
159594 522 None 45 Rat Binding pKi = 10.3 10.3 -1 3
binding affinity against human Endothelin A receptorbinding affinity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
3487 522 None 45 Rat Binding pKi = 10.3 10.3 -1 3
binding affinity against human Endothelin A receptorbinding affinity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
CHEMBL9194 522 None 45 Rat Binding pKi = 10.3 10.3 -1 3
binding affinity against human Endothelin A receptorbinding affinity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
DB06199 522 None 45 Rat Binding pKi = 10.3 10.3 -1 3
binding affinity against human Endothelin A receptorbinding affinity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
11082168 99213 None 0 Human Binding pKi = 10.3 10.3 7585 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 548 8 1 7 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC(F)(F)F)c1C 10.1021/jm020289q
CHEMBL281549 99213 None 0 Human Binding pKi = 10.3 10.3 7585 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 548 8 1 7 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC(F)(F)F)c1C 10.1021/jm020289q
10929533 100353 None 0 Human Binding pKi = 10.3 10.3 10964 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 534 9 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C(=O)C(C)C)C2CC2)c1C 10.1021/jm020289q
CHEMBL28963 100353 None 0 Human Binding pKi = 10.3 10.3 10964 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 534 9 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C(=O)C(C)C)C2CC2)c1C 10.1021/jm020289q
9914310 206641 None 8 Human Binding pKi = 10.2 10.2 1995 2
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL8923 206641 None 8 Human Binding pKi = 10.2 10.2 1995 2
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
11762890 100661 None 0 Human Binding pKi = 10.2 10.2 14791 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 505 8 2 9 5.3 Cc1cc(NCc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)no1 10.1021/jm020289q
CHEMBL29223 100661 None 0 Human Binding pKi = 10.2 10.2 14791 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 505 8 2 9 5.3 Cc1cc(NCc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)no1 10.1021/jm020289q
131845706 3470 None 6 Rat Binding pKi = 10.1 10.1 -11 2
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL None None None None 10.1021/jm00087a001
71308726 3470 None 6 Rat Binding pKi = 10.1 10.1 -11 2
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL None None None None 10.1021/jm00087a001
995 3470 None 6 Rat Binding pKi = 10.1 10.1 -11 2
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL None None None None 10.1021/jm00087a001
CHEMBL1222310 3470 None 6 Rat Binding pKi = 10.1 10.1 -11 2
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL None None None None 10.1021/jm00087a001
CHEMBL4524099 3470 None 6 Rat Binding pKi = 10.1 10.1 -11 2
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL None None None None 10.1021/jm00087a001
44284481 213723 None 0 Rat Binding pKi = 10.0 10.0 -6 5
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
CHEMBL437472 213723 None 0 Rat Binding pKi = 10.0 10.0 -6 5
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
9937336 174677 None 1 Human Binding pKi = 10.0 10.0 229 2
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 510 9 1 7 4.8 CCCc1nc(C)ccc1O[C@@H](C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/j.bmcl.2016.06.014
CHEMBL4559129 174677 None 1 Human Binding pKi = 10.0 10.0 229 2
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 510 9 1 7 4.8 CCCc1nc(C)ccc1O[C@@H](C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/j.bmcl.2016.06.014
9865409 102327 None 0 Human Binding pKi = 9.9 9.9 199 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 394 8 1 6 3.2 COc1cc(C)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
CHEMBL303631 102327 None 0 Human Binding pKi = 9.9 9.9 199 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 394 8 1 6 3.2 COc1cc(C)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
9894460 206707 None 9 Human Binding pKi = 9.9 9.9 24 3
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm9505369
CHEMBL313871 206707 None 9 Human Binding pKi = 9.9 9.9 24 3
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm9505369
CHEMBL8978 206707 None 9 Human Binding pKi = 9.9 9.9 24 3
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm9505369
12286 947 None 36 Human Binding pKi = 9.9 9.9 1348 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1021/jm980217s
6433095 947 None 36 Human Binding pKi = 9.9 9.9 1348 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1021/jm980217s
CHEMBL109648 947 None 36 Human Binding pKi = 9.9 9.9 1348 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1021/jm980217s
DB06677 947 None 36 Human Binding pKi = 9.9 9.9 1348 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1021/jm980217s
44284481 213723 None 0 Human Binding pKi = 9.9 9.9 -4 5
Displacement of [125I]Endothelin-1 from human recombinant ETA receptor expressed in CHOK1 cells after 2 hrsDisplacement of [125I]Endothelin-1 from human recombinant ETA receptor expressed in CHOK1 cells after 2 hrs
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/j.bmcl.2013.01.025
CHEMBL437472 213723 None 0 Human Binding pKi = 9.9 9.9 -4 5
Displacement of [125I]Endothelin-1 from human recombinant ETA receptor expressed in CHOK1 cells after 2 hrsDisplacement of [125I]Endothelin-1 from human recombinant ETA receptor expressed in CHOK1 cells after 2 hrs
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/j.bmcl.2013.01.025
44284481 213723 None 0 Human Binding pKi = 9.9 9.9 -4 5
Displacement of radiolabeled endothelin-1 from human endothelin ETA receptorDisplacement of radiolabeled endothelin-1 from human endothelin ETA receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm8007618
CHEMBL437472 213723 None 0 Human Binding pKi = 9.9 9.9 -4 5
Displacement of radiolabeled endothelin-1 from human endothelin ETA receptorDisplacement of radiolabeled endothelin-1 from human endothelin ETA receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm8007618
10973161 101042 None 0 Human Binding pKi = 9.8 9.8 6456 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 502 8 2 9 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNc2ccncn2)c1C 10.1021/jm020289q
CHEMBL29464 101042 None 0 Human Binding pKi = 9.8 9.8 6456 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 502 8 2 9 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNc2ccncn2)c1C 10.1021/jm020289q
11103326 167903 None 0 Human Binding pKi = 9.8 9.8 12589 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 520 8 1 7 5.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)CC(F)(F)F)c1C 10.1021/jm020289q
CHEMBL431296 167903 None 0 Human Binding pKi = 9.8 9.8 12589 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 520 8 1 7 5.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)CC(F)(F)F)c1C 10.1021/jm020289q
9870830 206712 None 38 Human Binding pKi = 9.8 9.8 66 2
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9505369
CHEMBL8981 206712 None 38 Human Binding pKi = 9.8 9.8 66 2
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9505369
23670447 3027 None 2 Human Binding pKi = 9.8 9.8 114 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm980217s
999 3027 None 2 Human Binding pKi = 9.8 9.8 114 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm980217s
CHEMBL1204799 3027 None 2 Human Binding pKi = 9.8 9.8 114 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm980217s
CHEMBL25438 3027 None 2 Human Binding pKi = 9.8 9.8 114 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm980217s
108002 3492 None 23 Human Binding pKi = 9.7 9.7 56 2
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm970101g
3528 3492 None 23 Human Binding pKi = 9.7 9.7 56 2
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm970101g
CHEMBL8823 3492 None 23 Human Binding pKi = 9.7 9.7 56 2
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm970101g
11754273 100971 None 0 Human Binding pKi = 9.7 9.7 21877 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 466 7 2 7 4.1 CC(=O)NCc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm000105c
CHEMBL29422 100971 None 0 Human Binding pKi = 9.7 9.7 21877 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 466 7 2 7 4.1 CC(=O)NCc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm000105c
11059912 99338 None 0 Human Binding pKi = 9.7 9.7 23988 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 481 9 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COCC(C)C)c1C 10.1021/jm020289q
CHEMBL282303 99338 None 0 Human Binding pKi = 9.7 9.7 23988 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 481 9 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COCC(C)C)c1C 10.1021/jm020289q
10972867 99701 None 0 Human Binding pKi = 9.7 9.7 19952 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 480 7 1 7 4.4 CC(=O)N(C)Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm020289q
CHEMBL284656 99701 None 0 Human Binding pKi = 9.7 9.7 19952 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 480 7 1 7 4.4 CC(=O)N(C)Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm020289q
11754273 100971 None 0 Human Binding pKi = 9.7 9.7 21877 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 466 7 2 7 4.1 CC(=O)NCc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm020289q
CHEMBL29422 100971 None 0 Human Binding pKi = 9.7 9.7 21877 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 466 7 2 7 4.1 CC(=O)NCc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm020289q
131845706 3470 None 6 Rat Binding pKi = 9.6 9.6 -11 2
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL None None None None 10.1021/jm00087a001
71308726 3470 None 6 Rat Binding pKi = 9.6 9.6 -11 2
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL None None None None 10.1021/jm00087a001
995 3470 None 6 Rat Binding pKi = 9.6 9.6 -11 2
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL None None None None 10.1021/jm00087a001
CHEMBL1222310 3470 None 6 Rat Binding pKi = 9.6 9.6 -11 2
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL None None None None 10.1021/jm00087a001
CHEMBL4524099 3470 None 6 Rat Binding pKi = 9.6 9.6 -11 2
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL None None None None 10.1021/jm00087a001
46228086 199832 None 0 Mouse Binding pKi = 9.6 9.6 707 2
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 598 10 1 9 4.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCBr)c2)cc1 10.1016/j.bmc.2009.08.058
CHEMBL594265 199832 None 0 Mouse Binding pKi = 9.6 9.6 707 2
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 598 10 1 9 4.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCBr)c2)cc1 10.1016/j.bmc.2009.08.058
11123603 101794 None 0 Human Binding pKi = 9.5 9.5 14125 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 475 7 1 8 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2ccnc2)c1C 10.1021/jm020289q
CHEMBL30009 101794 None 0 Human Binding pKi = 9.5 9.5 14125 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 475 7 1 8 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2ccnc2)c1C 10.1021/jm020289q
11730445 101906 None 0 Human Binding pKi = 9.5 9.5 4677 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 475 7 1 8 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2cccn2)c1C 10.1021/jm020289q
CHEMBL30092 101906 None 0 Human Binding pKi = 9.5 9.5 4677 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 475 7 1 8 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2cccn2)c1C 10.1021/jm020289q
46228118 202540 None 0 Mouse Binding pKi = 9.4 9.4 263 2
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 690 13 1 12 4.7 COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCOc3ccc(S(C)(=O)=O)cc3)cc2)cc(OC)c1OC 10.1016/j.bmc.2009.08.058
CHEMBL611626 202540 None 0 Mouse Binding pKi = 9.4 9.4 263 2
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 690 13 1 12 4.7 COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCOc3ccc(S(C)(=O)=O)cc3)cc2)cc(OC)c1OC 10.1016/j.bmc.2009.08.058
11082049 99558 None 0 Human Binding pKi = 9.4 9.4 933 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 534 7 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCCC(C)(C)C2=O)c1C 10.1021/jm020289q
CHEMBL283610 99558 None 0 Human Binding pKi = 9.4 9.4 933 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 534 7 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCCC(C)(C)C2=O)c1C 10.1021/jm020289q
10432263 102150 None 0 Human Binding pKi = 9.4 9.4 85 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 420 8 1 6 3.4 COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCC2 10.1021/jm960274q
CHEMBL302564 102150 None 0 Human Binding pKi = 9.4 9.4 85 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 420 8 1 6 3.4 COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCC2 10.1021/jm960274q
10864118 101466 None 0 Human Binding pKi = 9.4 9.4 4265 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 508 8 1 7 5.2 CC(=O)N(Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C)C(C)C 10.1021/jm020289q
CHEMBL29775 101466 None 0 Human Binding pKi = 9.4 9.4 4265 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 508 8 1 7 5.2 CC(=O)N(Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C)C(C)C 10.1021/jm020289q
11477084 3608 None 53 Human Binding pKi = 9.4 9.4 1 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
216235 3608 None 53 Human Binding pKi = 9.4 9.4 1 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
3548 3608 None 53 Human Binding pKi = 9.4 9.4 1 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
3950 3608 None 53 Human Binding pKi = 9.4 9.4 1 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
CHEMBL282724 3608 None 53 Human Binding pKi = 9.4 9.4 1 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
DB06268 3608 None 53 Human Binding pKi = 9.4 9.4 1 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
11477084 3608 None 53 Rat Binding pKi = 9.4 9.4 -1 2
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
216235 3608 None 53 Rat Binding pKi = 9.4 9.4 -1 2
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
3548 3608 None 53 Rat Binding pKi = 9.4 9.4 -1 2
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
3950 3608 None 53 Rat Binding pKi = 9.4 9.4 -1 2
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
CHEMBL282724 3608 None 53 Rat Binding pKi = 9.4 9.4 -1 2
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
DB06268 3608 None 53 Rat Binding pKi = 9.4 9.4 -1 2
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
108002 3492 None 23 Human Binding pKi = 9.4 9.4 56 2
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm00037a003
3528 3492 None 23 Human Binding pKi = 9.4 9.4 56 2
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm00037a003
CHEMBL8823 3492 None 23 Human Binding pKi = 9.4 9.4 56 2
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm00037a003
108002 3492 None 23 Human Binding pKi = 9.4 9.4 56 2
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm9505369
3528 3492 None 23 Human Binding pKi = 9.4 9.4 56 2
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm9505369
CHEMBL8823 3492 None 23 Human Binding pKi = 9.4 9.4 56 2
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm9505369
44339756 110770 None 0 Human Binding pKi = 9.4 9.4 - 1
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 454 6 1 8 4.0 Cc1cc2c(cc1CC(=O)c1ccsc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm980217s
CHEMBL326059 110770 None 0 Human Binding pKi = 9.4 9.4 - 1
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 454 6 1 8 4.0 Cc1cc2c(cc1CC(=O)c1ccsc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm980217s
9849547 184004 None 0 Human Binding pKi = 9.4 9.4 34 2
Tested for in vitro inhibition of [125I]ET1 binding to CHO cells expressing human Endothelin A receptorTested for in vitro inhibition of [125I]ET1 binding to CHO cells expressing human Endothelin A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(=O)O)[C@@H](C(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL48196 184004 None 0 Human Binding pKi = 9.4 9.4 34 2
Tested for in vitro inhibition of [125I]ET1 binding to CHO cells expressing human Endothelin A receptorTested for in vitro inhibition of [125I]ET1 binding to CHO cells expressing human Endothelin A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(=O)O)[C@@H](C(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
11734435 101300 None 0 Human Binding pKi = 9.4 9.4 6456 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 562 9 1 7 6.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC2CCCCC2)c1C 10.1021/jm020289q
CHEMBL29652 101300 None 0 Human Binding pKi = 9.4 9.4 6456 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 562 9 1 7 6.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC2CCCCC2)c1C 10.1021/jm020289q
9915028 9409 None 18 Human Binding pKi = 9.3 9.3 28183 2
Affinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000348aPTSA EDNRAAffinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000348aPTSA EDNRA
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL5210307
CHEMBL111612 9409 None 18 Human Binding pKi = 9.3 9.3 28183 2
Affinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000348aPTSA EDNRAAffinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000348aPTSA EDNRA
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL5210307
CHEMBL4761843 9409 None 18 Human Binding pKi = 9.3 9.3 28183 2
Affinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000348aPTSA EDNRAAffinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000348aPTSA EDNRA
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL5210307
9915028 9409 None 18 Human Binding pKi = 9.3 9.3 28183 2
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm010237l
CHEMBL111612 9409 None 18 Human Binding pKi = 9.3 9.3 28183 2
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm010237l
CHEMBL4761843 9409 None 18 Human Binding pKi = 9.3 9.3 28183 2
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm010237l
9915028 9409 None 18 Human Binding pKi = 9.3 9.3 28183 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
CHEMBL111612 9409 None 18 Human Binding pKi = 9.3 9.3 28183 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
CHEMBL4761843 9409 None 18 Human Binding pKi = 9.3 9.3 28183 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
10815239 108556 None 0 Human Binding pKi = 9.3 9.3 125 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 500 10 1 7 5.0 COc1ccc(OC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
CHEMBL320224 108556 None 0 Human Binding pKi = 9.3 9.3 125 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 500 10 1 7 5.0 COc1ccc(OC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
11794992 4970 None 0 Human Binding pKi = 9.3 9.3 39810 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 395 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cocn3)cc2)c1C 10.1021/jm000105c
CHEMBL104848 4970 None 0 Human Binding pKi = 9.3 9.3 39810 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 395 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cocn3)cc2)c1C 10.1021/jm000105c
11812665 99766 None 0 Human Binding pKi = 9.2 9.2 18197 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 467 8 1 7 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COC(C)C)c1C 10.1021/jm020289q
CHEMBL285118 99766 None 0 Human Binding pKi = 9.2 9.2 18197 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 467 8 1 7 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COC(C)C)c1C 10.1021/jm020289q
11124545 101371 None 0 Human Binding pKi = 9.2 9.2 4168 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 557 9 1 8 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)Cc2ccccn2)c1C 10.1021/jm020289q
CHEMBL29710 101371 None 0 Human Binding pKi = 9.2 9.2 4168 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 557 9 1 8 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)Cc2ccccn2)c1C 10.1021/jm020289q
10907333 102080 None 0 Human Binding pKi = 9.2 9.2 1819 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 508 7 2 7 4.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CC(=O)NC(C)(C)C)c1C 10.1021/jm020289q
CHEMBL30215 102080 None 0 Human Binding pKi = 9.2 9.2 1819 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 508 7 2 7 4.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CC(=O)NC(C)(C)C)c1C 10.1021/jm020289q
10786696 102785 None 0 Human Binding pKi = 9.2 9.2 223 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 392 8 1 5 3.8 CCc1cc(C)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
CHEMBL305270 102785 None 0 Human Binding pKi = 9.2 9.2 223 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 392 8 1 5 3.8 CCc1cc(C)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
11081276 101221 None 0 Human Binding pKi = 9.1 9.1 2238 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 476 7 1 8 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cc2ncco2)c1C 10.1021/jm020289q
CHEMBL29598 101221 None 0 Human Binding pKi = 9.1 9.1 2238 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 476 7 1 8 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cc2ncco2)c1C 10.1021/jm020289q
10973218 100967 None 0 Human Binding pKi = 9.1 9.1 3388 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 506 8 2 7 5.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNCC(F)(F)F)c1C 10.1021/jm020289q
CHEMBL29420 100967 None 0 Human Binding pKi = 9.1 9.1 3388 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 506 8 2 7 5.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNCC(F)(F)F)c1C 10.1021/jm020289q
44311692 103164 None 0 Human Binding pKi = 9.1 9.1 -3 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 667 13 3 7 4.5 C=CCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL308102 103164 None 0 Human Binding pKi = 9.1 9.1 -3 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 667 13 3 7 4.5 C=CCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
9822616 121990 None 0 Human Binding pKi = 9.1 9.1 17782 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL359273 121990 None 0 Human Binding pKi = 9.1 9.1 17782 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
9979632 102899 None 0 Human Binding pKi = 9.1 9.1 41 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 422 8 1 7 2.8 COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCO2 10.1021/jm960274q
CHEMBL305980 102899 None 0 Human Binding pKi = 9.1 9.1 41 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 422 8 1 7 2.8 COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCO2 10.1021/jm960274q
17979744 18252 None 0 Human Binding pKi = 9 9.0 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 657 10 1 8 6.6 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CN3CCC(C)(C)C3=O)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL12703 18252 None 0 Human Binding pKi = 9 9.0 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 657 10 1 8 6.6 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CN3CCC(C)(C)C3=O)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
197712 102178 None 57 Human Binding pKi = 9 9.0 194 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 378 7 1 5 3.5 COC(c1ccccc1)(c1ccccc1)C(Oc1nc(C)cc(C)n1)C(=O)O 10.1021/jm960274q
CHEMBL302753 102178 None 57 Human Binding pKi = 9 9.0 194 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 378 7 1 5 3.5 COC(c1ccccc1)(c1ccccc1)C(Oc1nc(C)cc(C)n1)C(=O)O 10.1021/jm960274q
10763862 163215 None 0 Human Binding pKi = 9 9.0 1096 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 406 9 1 5 4.0 CCc1cc(CC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
CHEMBL418326 163215 None 0 Human Binding pKi = 9 9.0 1096 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 406 9 1 5 4.0 CCc1cc(CC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
11733544 99233 None 0 Human Binding pKi = 9 9.0 7244 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 480 7 1 7 4.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CC(=O)N(C)C)c1C 10.1021/jm020289q
CHEMBL281668 99233 None 0 Human Binding pKi = 9 9.0 7244 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 480 7 1 7 4.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CC(=O)N(C)C)c1C 10.1021/jm020289q
11103112 99866 None 0 Human Binding pKi = 9 9.0 4570 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 501 8 1 7 6.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COc2ccccc2)c1C 10.1021/jm020289q
CHEMBL28586 99866 None 0 Human Binding pKi = 9 9.0 4570 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 501 8 1 7 6.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COc2ccccc2)c1C 10.1021/jm020289q
45257114 199861 None 0 Mouse Binding pKi = 9.0 9.0 218 2
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 538 10 1 9 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCF)c2)cc1 10.1016/j.bmc.2009.08.058
CHEMBL594482 199861 None 0 Mouse Binding pKi = 9.0 9.0 218 2
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 538 10 1 9 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCF)c2)cc1 10.1016/j.bmc.2009.08.058
178103 167949 None 14 Human Binding pKi = 9.0 9.0 100 2
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 506 10 2 7 4.6 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm970101g
CHEMBL431651 167949 None 14 Human Binding pKi = 9.0 9.0 100 2
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 506 10 2 7 4.6 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm970101g
45257114 199861 None 0 Mouse Binding pKi = 9.0 9.0 218 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 538 10 1 9 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCF)c2)cc1 10.1021/jm101110w
CHEMBL594482 199861 None 0 Mouse Binding pKi = 9.0 9.0 218 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 538 10 1 9 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCF)c2)cc1 10.1021/jm101110w
178103 167949 None 14 Human Binding pKi = 9.0 9.0 100 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 506 10 2 7 4.6 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm980217s
CHEMBL431651 167949 None 14 Human Binding pKi = 9.0 9.0 100 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 506 10 2 7 4.6 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm980217s
46228117 199782 None 0 Mouse Binding pKi = 8.9 8.9 1 2
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 690 13 1 12 4.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOc3ccc(S(C)(=O)=O)cc3)c2)cc1 10.1016/j.bmc.2009.08.058
CHEMBL593928 199782 None 0 Mouse Binding pKi = 8.9 8.9 1 2
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 690 13 1 12 4.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOc3ccc(S(C)(=O)=O)cc3)c2)cc1 10.1016/j.bmc.2009.08.058
10840560 4665 None 0 Human Binding pKi = 8.9 8.9 2 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 558 13 1 8 5.2 COc1cc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc(OC)c1OC 10.1021/jm9910425
CHEMBL103201 4665 None 0 Human Binding pKi = 8.9 8.9 2 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 558 13 1 8 5.2 COc1cc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc(OC)c1OC 10.1021/jm9910425
13016 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1016/s0960-894x(01)00791-0
9843631 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1016/s0960-894x(01)00791-0
CHEMBL24461 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1016/s0960-894x(01)00791-0
13016 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm300682j
9843631 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm300682j
CHEMBL24461 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm300682j
13016 669 None 13 Rat Binding pKi = 8.9 8.9 -1 4
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm030528p
9843631 669 None 13 Rat Binding pKi = 8.9 8.9 -1 4
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm030528p
CHEMBL24461 669 None 13 Rat Binding pKi = 8.9 8.9 -1 4
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm030528p
13016 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Compound was evaluated for its binding affinity towards human Endothelin A receptorCompound was evaluated for its binding affinity towards human Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm020138n
9843631 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Compound was evaluated for its binding affinity towards human Endothelin A receptorCompound was evaluated for its binding affinity towards human Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm020138n
CHEMBL24461 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Compound was evaluated for its binding affinity towards human Endothelin A receptorCompound was evaluated for its binding affinity towards human Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm020138n
13016 669 None 13 Rat Binding pKi = 8.9 8.9 -1 4
Displacement of [125I]-ET1 from ETA receptor in A10 rat thoracic aorta smooth muscle after 3 hrs by scintillation counting methodDisplacement of [125I]-ET1 from ETA receptor in A10 rat thoracic aorta smooth muscle after 3 hrs by scintillation counting method
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1016/j.bmcl.2016.06.014
9843631 669 None 13 Rat Binding pKi = 8.9 8.9 -1 4
Displacement of [125I]-ET1 from ETA receptor in A10 rat thoracic aorta smooth muscle after 3 hrs by scintillation counting methodDisplacement of [125I]-ET1 from ETA receptor in A10 rat thoracic aorta smooth muscle after 3 hrs by scintillation counting method
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1016/j.bmcl.2016.06.014
CHEMBL24461 669 None 13 Rat Binding pKi = 8.9 8.9 -1 4
Displacement of [125I]-ET1 from ETA receptor in A10 rat thoracic aorta smooth muscle after 3 hrs by scintillation counting methodDisplacement of [125I]-ET1 from ETA receptor in A10 rat thoracic aorta smooth muscle after 3 hrs by scintillation counting method
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1016/j.bmcl.2016.06.014
51003306 58061 None 0 Mouse Binding pKi = 8.9 8.9 295 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 670 19 1 12 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCF)c2)cc1 10.1021/jm101110w
CHEMBL1672880 58061 None 0 Mouse Binding pKi = 8.9 8.9 295 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 670 19 1 12 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCF)c2)cc1 10.1021/jm101110w
13016 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm000105c
9843631 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm000105c
CHEMBL24461 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm000105c
13016 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm020289q
9843631 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm020289q
CHEMBL24461 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm020289q
13016 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm030480f
9843631 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm030480f
CHEMBL24461 669 None 13 Human Binding pKi = 8.9 8.9 1 4
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm030480f
9938533 105411 None 4 Human Binding pKi = 8.8 8.8 -1 2
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL311854 105411 None 4 Human Binding pKi = 8.8 8.8 -1 2
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
10553793 4459 None 0 Human Binding pKi = 8.8 8.8 75 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 512 11 2 6 4.8 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(C(=O)O)cc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
CHEMBL101742 4459 None 0 Human Binding pKi = 8.8 8.8 75 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 512 11 2 6 4.8 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(C(=O)O)cc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
11113812 100794 None 0 Human Binding pKi = 8.8 8.8 1258 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 497 7 1 6 6.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2/C=C\c2ccccc2)c1C 10.1021/jm020289q
CHEMBL29313 100794 None 0 Human Binding pKi = 8.8 8.8 1258 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 497 7 1 6 6.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2/C=C\c2ccccc2)c1C 10.1021/jm020289q
CHEMBL1790180 208881 None 0 Rat Binding pKi = 8.8 8.8 -72 3
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCc3ccc(O)cc3)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
9938533 105411 None 4 Human Binding pKi = 8.7 8.7 -1 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00387-4
CHEMBL311854 105411 None 4 Human Binding pKi = 8.7 8.7 -1 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00387-4
9895957 10671 None 18 Human Binding pKi = 8.7 8.7 3 3
Binding affinity at endothelin receptor subtype ABinding affinity at endothelin receptor subtype A
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1016/j.bmc.2012.06.011
CHEMBL11706 10671 None 18 Human Binding pKi = 8.7 8.7 3 3
Binding affinity at endothelin receptor subtype ABinding affinity at endothelin receptor subtype A
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1016/j.bmc.2012.06.011
44311728 104351 None 0 Human Binding pKi = 8.7 8.7 -13 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 653 12 3 7 4.4 C=CS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL310039 104351 None 0 Human Binding pKi = 8.7 8.7 -13 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 653 12 3 7 4.4 C=CS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
9895957 10671 None 18 Human Binding pKi = 8.7 8.7 3 3
Compound was evaluated for its binding affinity towards human Endothelin A receptorCompound was evaluated for its binding affinity towards human Endothelin A receptor
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1021/jm020138n
CHEMBL11706 10671 None 18 Human Binding pKi = 8.7 8.7 3 3
Compound was evaluated for its binding affinity towards human Endothelin A receptorCompound was evaluated for its binding affinity towards human Endothelin A receptor
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1021/jm020138n
9895957 10671 None 18 Human Binding pKi = 8.7 8.7 3 3
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1021/jm058225d
CHEMBL11706 10671 None 18 Human Binding pKi = 8.7 8.7 3 3
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1021/jm058225d
10555112 4735 None 0 Human Binding pKi = 8.7 8.7 12 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 572 14 2 8 4.6 COc1cc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)ccc1OCC(=O)O 10.1021/jm9910425
CHEMBL103695 4735 None 0 Human Binding pKi = 8.7 8.7 12 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 572 14 2 8 4.6 COc1cc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)ccc1OCC(=O)O 10.1021/jm9910425
11799974 4529 None 0 Human Binding pKi = 8.7 8.7 12 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 514 12 1 7 4.8 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL102307 4529 None 0 Human Binding pKi = 8.7 8.7 12 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 514 12 1 7 4.8 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 10.1021/jm9910425
44311805 204564 None 0 Human Binding pKi = 8 8.0 -26 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 669 12 3 7 4.7 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)C(C)C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL73000 204564 None 0 Human Binding pKi = 8 8.0 -26 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 669 12 3 7 4.7 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)C(C)C)c1 10.1016/s0960-894x(98)00387-4
13015 1529 None 30 Human Binding pKi = 8 8.0 - 1
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 536 8 1 7 5.8 CC1=C(ON=C1NS(=O)(=O)C2=CC=CC=C2C3=C(C=C(C=C3)C4=NC=CO4)CN(C)C(=O)CC(C)(C)C)C 10.1021/jm058225d
156690 1529 None 30 Human Binding pKi = 8 8.0 - 1
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 536 8 1 7 5.8 CC1=C(ON=C1NS(=O)(=O)C2=CC=CC=C2C3=C(C=C(C=C3)C4=NC=CO4)CN(C)C(=O)CC(C)(C)C)C 10.1021/jm058225d
CHEMBL383581 1529 None 30 Human Binding pKi = 8 8.0 - 1
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 536 8 1 7 5.8 CC1=C(ON=C1NS(=O)(=O)C2=CC=CC=C2C3=C(C=C(C=C3)C4=NC=CO4)CN(C)C(=O)CC(C)(C)C)C 10.1021/jm058225d
10812403 39098 None 0 Rat Binding pKi = 7 7.0 120 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 7 2 5 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2C(N)=O)c1C 10.1021/jm970872k
CHEMBL146904 39098 None 0 Rat Binding pKi = 7 7.0 120 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 7 2 5 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2C(N)=O)c1C 10.1021/jm970872k
10573784 165335 None 0 Rat Binding pKi = 7 7.0 95 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 413 7 2 5 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CN)c1C 10.1021/jm970872k
CHEMBL423583 165335 None 0 Rat Binding pKi = 7 7.0 95 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 413 7 2 5 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CN)c1C 10.1021/jm970872k
1481 2064 None 116 Human Binding pKi = 5 5.0 -112 3
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
3749 2064 None 116 Human Binding pKi = 5 5.0 -112 3
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
589 2064 None 116 Human Binding pKi = 5 5.0 -112 3
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
6908 2064 None 116 Human Binding pKi = 5 5.0 -112 3
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
CHEMBL1513 2064 None 116 Human Binding pKi = 5 5.0 -112 3
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
DB01029 2064 None 116 Human Binding pKi = 5 5.0 -112 3
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
10619232 121993 None 0 Rat Binding pKi = 7.0 7.0 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 371 5 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2N(C)C)c1C 10.1021/jm970872k
CHEMBL359332 121993 None 0 Rat Binding pKi = 7.0 7.0 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 371 5 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2N(C)C)c1C 10.1021/jm970872k
44267891 18757 None 0 Human Binding pKi = 7.0 7.0 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 532 8 1 7 5.9 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL12779 18757 None 0 Human Binding pKi = 7.0 7.0 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 532 8 1 7 5.9 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
44333366 107424 None 0 Human Binding pKi = 7.0 7.0 -1 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 570 12 1 8 5.2 COc1ccc(CCOC(c2ccc(C)cc2)(c2ccc(C)cc2)C(Oc2nc3c(c(OC)n2)COC3)C(=O)O)cc1 10.1021/jm9910425
CHEMBL318146 107424 None 0 Human Binding pKi = 7.0 7.0 -1 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 570 12 1 8 5.2 COc1ccc(CCOC(c2ccc(C)cc2)(c2ccc(C)cc2)C(Oc2nc3c(c(OC)n2)COC3)C(=O)O)cc1 10.1021/jm9910425
10742005 203695 None 0 Human Binding pKi = 8.0 8.0 162 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 446 9 1 7 3.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2cccc(F)c2)c2cccc(F)c2)n1 10.1021/jm960274q
CHEMBL67536 203695 None 0 Human Binding pKi = 8.0 8.0 162 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 446 9 1 7 3.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2cccc(F)c2)c2cccc(F)c2)n1 10.1021/jm960274q
10740258 109676 None 0 Human Binding pKi = 8.0 8.0 1096 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)o1 10.1021/jm000105c
CHEMBL322674 109676 None 0 Human Binding pKi = 8.0 8.0 1096 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)o1 10.1021/jm000105c
10321341 145434 None 0 Human Binding pKi = 8.0 8.0 93 2
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 446 7 1 5 5.2 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm00037a003
CHEMBL39142 145434 None 0 Human Binding pKi = 8.0 8.0 93 2
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 446 7 1 5 5.2 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm00037a003
10598958 41432 None 0 Rat Binding pKi = 7.0 7.0 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 434 6 1 6 3.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(S(=O)(=O)C(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL149050 41432 None 0 Rat Binding pKi = 7.0 7.0 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 434 6 1 6 3.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(S(=O)(=O)C(C)C)cc2)c1C 10.1021/jm970872k
10715881 121539 None 0 Rat Binding pKi = 7.0 7.0 37 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 5 1 4 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL358545 121539 None 0 Rat Binding pKi = 7.0 7.0 37 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 5 1 4 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)(C)C)cc2)c1C 10.1021/jm970872k
9848710 169078 None 4 Pig Binding pKi = 5.0 5.0 -301 4
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 497 9 3 3 4.3 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/0960-894X(96)00421-0
CHEMBL439759 169078 None 4 Pig Binding pKi = 5.0 5.0 -301 4
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 497 9 3 3 4.3 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/0960-894X(96)00421-0
9848710 169078 None 4 Human Binding pKi = 5.0 5.0 -301 4
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 497 9 3 3 4.3 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
CHEMBL439759 169078 None 4 Human Binding pKi = 5.0 5.0 -301 4
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 497 9 3 3 4.3 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
10761748 121024 None 0 Rat Binding pKi = 7.0 7.0 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 371 5 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(N(C)C)c2)c1C 10.1021/jm970872k
CHEMBL356591 121024 None 0 Rat Binding pKi = 7.0 7.0 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 371 5 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(N(C)C)c2)c1C 10.1021/jm970872k
44286764 145819 None 0 Human Binding pKi = 5.0 5.0 - 1
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 314 3 1 1 4.7 O=C(O)[C@@H]1[C@@H](c2ccccc2)c2ccccc2[C@H]1c1ccccc1 10.1021/jm00037a003
CHEMBL39171 145819 None 0 Human Binding pKi = 5.0 5.0 - 1
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 314 3 1 1 4.7 O=C(O)[C@@H]1[C@@H](c2ccccc2)c2ccccc2[C@H]1c1ccccc1 10.1021/jm00037a003
10503999 41312 None 0 Rat Binding pKi = 5.9 5.9 6 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 456 8 3 6 3.9 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)CN)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL148953 41312 None 0 Rat Binding pKi = 5.9 5.9 6 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 456 8 3 6 3.9 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)CN)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
10762600 168300 None 0 Rat Binding pKi = 7.9 7.9 154 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 6 1 4 5.0 Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL434082 168300 None 0 Rat Binding pKi = 7.9 7.9 154 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 6 1 4 5.0 Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
10209324 14488 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 546 8 1 7 6.2 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL12013 14488 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 546 8 1 7 6.2 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
44311851 204661 None 0 Human Binding pKi = 6.9 6.9 -162 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 564 10 3 5 4.9 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccon3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
CHEMBL73697 204661 None 0 Human Binding pKi = 6.9 6.9 -162 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 564 10 3 5 4.9 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccon3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
10692125 203061 None 0 Human Binding pKi = 6.9 6.9 26 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 396 8 2 7 2.3 COc1cc(OC)nc(OC(C(=O)O)C(O)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
CHEMBL63648 203061 None 0 Human Binding pKi = 6.9 6.9 26 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 396 8 2 7 2.3 COc1cc(OC)nc(OC(C(=O)O)C(O)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
44314607 161259 None 0 Pig Binding pKi = 5.9 5.9 -1412 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1534 46 19 18 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
77282208 161259 None 0 Pig Binding pKi = 5.9 5.9 -1412 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1534 46 19 18 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
CHEMBL412003 161259 None 0 Pig Binding pKi = 5.9 5.9 -1412 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1534 46 19 18 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
10620897 41614 None 0 Rat Binding pKi = 5.9 5.9 14 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 6 1 4 5.3 Cc1cccc(-c2ccc(CC(C)C)cc2)c1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL149171 41614 None 0 Rat Binding pKi = 5.9 5.9 14 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 6 1 4 5.3 Cc1cccc(-c2ccc(CC(C)C)cc2)c1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL4513786 213965 None 7 Human Binding pKi = 4.9 4.9 -2344 8
Affinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000289bCl EDNRAAffinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000289bCl EDNRA
ChEMBL None None None CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC 10.6019/CHEMBL5210307
CHEMBL4796803 213965 None 7 Human Binding pKi = 4.9 4.9 -2344 8
Affinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000289bCl EDNRAAffinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000289bCl EDNRA
ChEMBL None None None CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC 10.6019/CHEMBL5210307
5344 173471 None 101 Human Binding pKi = 4.9 4.9 - 1
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C nan
CHEMBL453 173471 None 101 Human Binding pKi = 4.9 4.9 - 1
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C nan
10740469 39303 None 0 Rat Binding pKi = 7.9 7.9 154 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 413 7 2 5 5.0 CNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL147081 39303 None 0 Rat Binding pKi = 7.9 7.9 154 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 413 7 2 5 5.0 CNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
10668636 121970 None 0 Rat Binding pKi = 7.9 7.9 147 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 399 6 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccc(N)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL359167 121970 None 0 Rat Binding pKi = 7.9 7.9 147 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 399 6 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccc(N)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
10166561 10062 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 562 9 2 8 5.4 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL11528 10062 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 562 9 2 8 5.4 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
10809354 121133 None 1 Rat Binding pKi = 6.9 6.9 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 373 5 1 6 3.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2[N+](=O)[O-])c1C 10.1021/jm970872k
CHEMBL357580 121133 None 1 Rat Binding pKi = 6.9 6.9 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 373 5 1 6 3.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2[N+](=O)[O-])c1C 10.1021/jm970872k
19934544 206198 None 0 Human Binding pKi = 4.9 4.9 -2 2
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 482 7 3 4 4.9 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)Cc3c[nH]c4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
CHEMBL86489 206198 None 0 Human Binding pKi = 4.9 4.9 -2 2
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 482 7 3 4 4.9 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)Cc3c[nH]c4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
44267862 15360 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 571 9 1 8 5.9 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CC#N)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL12144 15360 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 571 9 1 8 5.9 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CC#N)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
10453858 160100 None 0 Human Binding pKi = 7.8 7.8 31 2
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 404 4 2 5 4.1 COc1ccc([C@@H]2c3cc(O)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1021/jm00037a003
CHEMBL41087 160100 None 0 Human Binding pKi = 7.8 7.8 31 2
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 404 4 2 5 4.1 COc1ccc([C@@H]2c3cc(O)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1021/jm00037a003
10837085 102307 None 0 Human Binding pKi = 6.8 6.8 39 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 446 9 1 7 3.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2F)c2ccccc2F)n1 10.1021/jm960274q
CHEMBL303501 102307 None 0 Human Binding pKi = 6.8 6.8 39 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 446 9 1 7 3.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2F)c2ccccc2F)n1 10.1021/jm960274q
10670204 41532 None 0 Rat Binding pKi = 5.8 5.8 17 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 428 7 2 5 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2C(=O)O)c1C 10.1021/jm970872k
CHEMBL149111 41532 None 0 Rat Binding pKi = 5.8 5.8 17 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 428 7 2 5 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2C(=O)O)c1C 10.1021/jm970872k
10603135 109742 None 0 Human Binding pKi = 6.8 6.8 1 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 570 14 1 7 6.0 CCc1ccc(C(OCCc2ccc(OC)cc2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL322996 109742 None 0 Human Binding pKi = 6.8 6.8 1 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 570 14 1 7 6.0 CCc1ccc(C(OCCc2ccc(OC)cc2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 10.1021/jm9910425
10521320 119763 None 0 Rat Binding pKi = 7.8 7.8 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 343 4 2 5 3.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2N)c1C 10.1021/jm970872k
CHEMBL347958 119763 None 0 Rat Binding pKi = 7.8 7.8 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 343 4 2 5 3.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2N)c1C 10.1021/jm970872k
10549727 164885 None 0 Rat Binding pKi = 7.8 7.8 125 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 1 5 5.0 COc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1-c1ccc(CC(C)C)cc1 10.1021/jm970872k
CHEMBL422128 164885 None 0 Rat Binding pKi = 7.8 7.8 125 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 1 5 5.0 COc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1-c1ccc(CC(C)C)cc1 10.1021/jm970872k
44267893 98415 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 535 10 2 7 4.9 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
CHEMBL275523 98415 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 535 10 2 7 4.9 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
10740953 5314 None 0 Human Binding pKi = 7.8 7.8 758 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 423 5 1 6 5.0 Cc1nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)oc1C 10.1021/jm000105c
CHEMBL106749 5314 None 0 Human Binding pKi = 7.8 7.8 758 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 423 5 1 6 5.0 Cc1nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)oc1C 10.1021/jm000105c
44274885 94084 None 0 Human Binding pKi = 6.8 6.8 29 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 454 10 1 7 4.5 COc1cc(OC)nc(CC(C(=O)O)C(C)(Oc2ccc(SC)cc2)c2ccccc2)n1 10.1021/jm030480f
CHEMBL24906 94084 None 0 Human Binding pKi = 6.8 6.8 29 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 454 10 1 7 4.5 COc1cc(OC)nc(CC(C(=O)O)C(C)(Oc2ccc(SC)cc2)c2ccccc2)n1 10.1021/jm030480f
44307287 203756 None 0 Human Binding pKi = 6.8 6.8 29 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 470 10 0 9 4.1 COC(=O)C(Oc1nc(OC)cc(OC)n1)C(C)(Oc1ccc(SC)cc1)c1ccccc1 10.1021/jm960274q
CHEMBL67957 203756 None 0 Human Binding pKi = 6.8 6.8 29 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 470 10 0 9 4.1 COC(=O)C(Oc1nc(OC)cc(OC)n1)C(C)(Oc1ccc(SC)cc1)c1ccccc1 10.1021/jm960274q
176 398 None 66 Human Binding pKi = 4.8 4.8 -7 31
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2157 398 None 66 Human Binding pKi = 4.8 4.8 -7 31
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2566 398 None 66 Human Binding pKi = 4.8 4.8 -7 31
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
CHEMBL633 398 None 66 Human Binding pKi = 4.8 4.8 -7 31
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
DB01118 398 None 66 Human Binding pKi = 4.8 4.8 -7 31
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
10620185 119649 None 0 Rat Binding pKi = 7.8 7.8 89 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 386 6 1 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL346853 119649 None 0 Rat Binding pKi = 7.8 7.8 89 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 386 6 1 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OC(C)C)cc2)c1C 10.1021/jm970872k
10741144 119767 None 0 Rat Binding pKi = 7.8 7.8 407 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 8 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NC=O)c1C 10.1021/jm970872k
CHEMBL347982 119767 None 0 Rat Binding pKi = 7.8 7.8 407 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 8 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NC=O)c1C 10.1021/jm970872k
17979733 97241 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 576 10 1 8 6.0 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(COC)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL268706 97241 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 576 10 1 8 6.0 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(COC)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
44303033 203216 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 472 6 1 5 5.4 COc1ccc(CC2C(c3ccc(Cl)c(Cl)c3)C(=O)O[C@@]2(O)c2ccc(OC)cc2)cc1 10.1021/jm990504b
CHEMBL64424 203216 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 472 6 1 5 5.4 COc1ccc(CC2C(c3ccc(Cl)c(Cl)c3)C(=O)O[C@@]2(O)c2ccc(OC)cc2)cc1 10.1021/jm990504b
9934204 106943 None 0 Human Binding pKi = 4.8 4.8 -1 2
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 465 7 2 4 6.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NCc3cccc4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
CHEMBL314915 106943 None 0 Human Binding pKi = 4.8 4.8 -1 2
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 465 7 2 4 6.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NCc3cccc4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
10836754 203588 None 0 Human Binding pKi = 6.8 6.8 14 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 11 1 7 3.7 CCOc1cc(OCC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
CHEMBL66893 203588 None 0 Human Binding pKi = 6.8 6.8 14 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 11 1 7 3.7 CCOc1cc(OCC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
10691437 5080 None 0 Rat Binding pKi = 7.8 7.8 -1 4
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 6 1 4 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL105490 5080 None 0 Rat Binding pKi = 7.8 7.8 -1 4
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 6 1 4 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
443289 710 None 47 Human Binding pKi = 7.8 7.8 2 3
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL None None None None 10.1016/0960-894X(95)00019-P
997 710 None 47 Human Binding pKi = 7.8 7.8 2 3
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL None None None None 10.1016/0960-894X(95)00019-P
CHEMBL314691 710 None 47 Human Binding pKi = 7.8 7.8 2 3
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL None None None None 10.1016/0960-894X(95)00019-P
DB12054 710 None 47 Human Binding pKi = 7.8 7.8 2 3
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL None None None None 10.1016/0960-894X(95)00019-P
10691437 5080 None 0 Human Binding pKi = 7.8 7.8 1 4
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 384 6 1 4 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm000105c
CHEMBL105490 5080 None 0 Human Binding pKi = 7.8 7.8 1 4
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 384 6 1 4 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm000105c
CHEMBL1201469 14505 None 0 Human Binding pKi = 5.7 5.7 -1 4
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL None None None None nan
22103797 41376 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 408 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nccn3C)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL149010 41376 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 408 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nccn3C)cc2)c1C 10.1016/s0960-894x(01)00791-0
5122650 102929 None 5 Human Binding pKi = 7.7 7.7 100 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 364 7 1 5 3.2 COC(c1ccccc1)(c1ccccc1)C(Oc1nccc(C)n1)C(=O)O 10.1021/jm960274q
CHEMBL306218 102929 None 5 Human Binding pKi = 7.7 7.7 100 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 364 7 1 5 3.2 COC(c1ccccc1)(c1ccccc1)C(Oc1nccc(C)n1)C(=O)O 10.1021/jm960274q
11797288 203614 None 0 Human Binding pKi = 7.7 7.7 89 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 11 1 7 3.7 CCCOC(c1ccccc1)(c1ccccc1)C(Oc1nc(OC)cc(OC)n1)C(=O)O 10.1021/jm960274q
CHEMBL67084 203614 None 0 Human Binding pKi = 7.7 7.7 89 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 11 1 7 3.7 CCCOC(c1ccccc1)(c1ccccc1)C(Oc1nc(OC)cc(OC)n1)C(=O)O 10.1021/jm960274q
10669224 108464 None 0 Human Binding pKi = 7.7 7.7 1778 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 6 1 6 4.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cc3ncco3)cc2)c1C 10.1021/jm000105c
CHEMBL319924 108464 None 0 Human Binding pKi = 7.7 7.7 1778 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 6 1 6 4.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cc3ncco3)cc2)c1C 10.1021/jm000105c
10673091 163323 None 0 Human Binding pKi = 7.7 7.7 4 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 502 10 1 5 5.8 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(Cl)cc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
CHEMBL418992 163323 None 0 Human Binding pKi = 7.7 7.7 4 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 502 10 1 5 5.8 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(Cl)cc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
10836583 39691 None 0 Rat Binding pKi = 6.7 6.7 43 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 434 7 1 5 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OCc3ccccc3)cc2)c1C 10.1021/jm970872k
CHEMBL147521 39691 None 0 Rat Binding pKi = 6.7 6.7 43 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 434 7 1 5 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OCc3ccccc3)cc2)c1C 10.1021/jm970872k
10643748 121435 None 0 Rat Binding pKi = 6.7 6.7 29 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 6 1 4 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(CC(C)C)c2)c1C 10.1021/jm970872k
CHEMBL358226 121435 None 0 Rat Binding pKi = 6.7 6.7 29 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 6 1 4 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(CC(C)C)c2)c1C 10.1021/jm970872k
10813050 44051 None 0 Rat Binding pKi = 8.7 8.7 602 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 9 2 5 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CNC=O)c1C 10.1021/jm970872k
CHEMBL151440 44051 None 0 Rat Binding pKi = 8.7 8.7 602 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 9 2 5 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CNC=O)c1C 10.1021/jm970872k
9895957 10671 None 18 Human Binding pKi = 8.7 8.7 3 3
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1016/s0960-894x(03)00018-0
CHEMBL11706 10671 None 18 Human Binding pKi = 8.7 8.7 3 3
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1016/s0960-894x(03)00018-0
10835335 4835 None 0 Human Binding pKi = 8.7 8.7 50118 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1coc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)n1 10.1021/jm000105c
CHEMBL104223 4835 None 0 Human Binding pKi = 8.7 8.7 50118 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1coc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)n1 10.1021/jm000105c
11799973 4430 None 0 Human Binding pKi = 8.7 8.7 31 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 514 11 1 7 5.1 COc1ccc(COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
CHEMBL101587 4430 None 0 Human Binding pKi = 8.7 8.7 31 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 514 11 1 7 5.1 COc1ccc(COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
9893800 107228 None 12 Human Binding pKi = 8.7 8.7 2 2
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counting method
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)[C@H](Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/acs.jmedchem.5b01781
CHEMBL316735 107228 None 12 Human Binding pKi = 8.7 8.7 2 2
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counting method
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)[C@H](Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/acs.jmedchem.5b01781
9893800 107228 None 12 Human Binding pKi = 8.7 8.7 2 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)[C@H](Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
CHEMBL316735 107228 None 12 Human Binding pKi = 8.7 8.7 2 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)[C@H](Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
44311727 204467 None 0 Human Binding pKi = 8.7 8.7 -9 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 669 13 3 7 4.7 CCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL72348 204467 None 0 Human Binding pKi = 8.7 8.7 -9 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 669 13 3 7 4.7 CCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
76312118 85345 None 0 Human Binding pKi = 8.7 8.7 691 2
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261361 85345 None 0 Human Binding pKi = 8.7 8.7 691 2
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
18660521 41695 None 0 Human Binding pKi = 8.6 8.6 2754 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 405 5 1 5 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL149232 41695 None 0 Human Binding pKi = 8.6 8.6 2754 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 405 5 1 5 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
44311915 104789 None 0 Human Binding pKi = 8.6 8.6 -6 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 703 12 3 7 5.4 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)c2ccccc2)c1 10.1016/s0960-894x(98)00387-4
CHEMBL310920 104789 None 0 Human Binding pKi = 8.6 8.6 -6 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 703 12 3 7 5.4 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)c2ccccc2)c1 10.1016/s0960-894x(98)00387-4
10768897 107655 None 1 Human Binding pKi = 8.6 8.6 6 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 544 13 1 8 4.8 COc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(OC)c(OC)c2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
CHEMBL319031 107655 None 1 Human Binding pKi = 8.6 8.6 6 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 544 13 1 8 4.8 COc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(OC)c(OC)c2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
51003307 58062 None 0 Mouse Binding pKi = 8.6 8.6 3548 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 751 21 1 15 4.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCc3cn(CCOCCOCCOCCF)nn3)c2)cc1 10.1021/jm101110w
CHEMBL1672881 58062 None 0 Mouse Binding pKi = 8.6 8.6 3548 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 751 21 1 15 4.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCc3cn(CCOCCOCCOCCF)nn3)c2)cc1 10.1021/jm101110w
45257115 201330 None 0 Mouse Binding pKi = 8.6 8.6 39 2
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 538 10 1 9 4.2 COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCF)cc2)cc(OC)c1OC 10.1016/j.bmc.2009.08.058
CHEMBL604286 201330 None 0 Mouse Binding pKi = 8.6 8.6 39 2
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 538 10 1 9 4.2 COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCF)cc2)cc(OC)c1OC 10.1016/j.bmc.2009.08.058
CHEMBL1790180 208881 None 0 Rat Binding pKi = 8.6 8.6 -72 3
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCc3ccc(O)cc3)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
11049336 99938 None 0 Human Binding pKi = 8.6 8.6 3630 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 497 7 1 6 6.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2/C=C/c2ccccc2)c1C 10.1021/jm020289q
CHEMBL286279 99938 None 0 Human Binding pKi = 8.6 8.6 3630 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 497 7 1 6 6.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2/C=C/c2ccccc2)c1C 10.1021/jm020289q
10670965 42324 None 0 Rat Binding pKi = 8.6 8.6 851 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 444 9 2 6 4.3 Cc1noc(NS(=O)(=O)c2cccc(OCCO)c2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL149819 42324 None 0 Rat Binding pKi = 8.6 8.6 851 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 444 9 2 6 4.3 Cc1noc(NS(=O)(=O)c2cccc(OCCO)c2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
44311804 103016 None 0 Human Binding pKi = 8.5 8.5 -12 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 683 14 3 7 5.1 CCCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL306950 103016 None 0 Human Binding pKi = 8.5 8.5 -12 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 683 14 3 7 5.1 CCCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
10501931 43871 None 0 Rat Binding pKi = 7.7 7.7 64 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CO)c1C 10.1021/jm970872k
CHEMBL151160 43871 None 0 Rat Binding pKi = 7.7 7.7 64 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CO)c1C 10.1021/jm970872k
10668819 121112 None 0 Rat Binding pKi = 7.7 7.7 602 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 402 6 1 4 5.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2F)c1C 10.1021/jm970872k
CHEMBL357395 121112 None 0 Rat Binding pKi = 7.7 7.7 602 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 402 6 1 4 5.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2F)c1C 10.1021/jm970872k
22574798 15518 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 579 13 2 8 5.2 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COCC)c1 10.1016/s0960-894x(03)00018-0
CHEMBL12175 15518 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 579 13 2 8 5.2 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COCC)c1 10.1016/s0960-894x(03)00018-0
17979749 17845 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 550 8 1 7 6.0 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(F)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL12590 17845 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 550 8 1 7 6.0 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(F)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
44267860 167123 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 590 11 1 8 6.4 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(COCC)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL429037 167123 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 590 11 1 8 6.4 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(COCC)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
10599129 102234 None 0 Human Binding pKi = 6.7 6.7 5 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 9 1 7 3.5 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(C)cc2)c2ccc(C)cc2)n1 10.1021/jm960274q
CHEMBL303034 102234 None 0 Human Binding pKi = 6.7 6.7 5 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 9 1 7 3.5 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(C)cc2)c2ccc(C)cc2)n1 10.1021/jm960274q
44314882 157174 None 0 Pig Binding pKi = 5.7 5.7 -380 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1562 47 19 18 0.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
77282212 157174 None 0 Pig Binding pKi = 5.7 5.7 -380 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1562 47 19 18 0.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
CHEMBL407559 157174 None 0 Pig Binding pKi = 5.7 5.7 -380 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1562 47 19 18 0.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
10813228 107658 None 0 Human Binding pKi = 5.7 5.7 46 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 445 5 1 6 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nc4ccccc4o3)cc2)c1C 10.1021/jm000105c
CHEMBL319036 107658 None 0 Human Binding pKi = 5.7 5.7 46 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 445 5 1 6 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nc4ccccc4o3)cc2)c1C 10.1021/jm000105c
10545378 39214 None 0 Rat Binding pKi = 5.7 5.7 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 344 5 1 5 3.9 Cc1noc(NS(=O)(=O)c2ccccc2Oc2ccccc2)c1C 10.1021/jm970872k
CHEMBL147007 39214 None 0 Rat Binding pKi = 5.7 5.7 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 344 5 1 5 3.9 Cc1noc(NS(=O)(=O)c2ccccc2Oc2ccccc2)c1C 10.1021/jm970872k
20747573 17148 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 593 13 2 8 5.4 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COCC)c1 10.1016/s0960-894x(03)00018-0
CHEMBL12557 17148 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 593 13 2 8 5.4 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COCC)c1 10.1016/s0960-894x(03)00018-0
10719157 102293 None 0 Human Binding pKi = 7.7 7.7 58 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 470 11 1 9 2.9 COc1cccc(C(OC)(c2cccc(OC)c2)C(Oc2nc(OC)cc(OC)n2)C(=O)O)c1 10.1021/jm960274q
CHEMBL303390 102293 None 0 Human Binding pKi = 7.7 7.7 58 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 470 11 1 9 2.9 COc1cccc(C(OC)(c2cccc(OC)c2)C(Oc2nc(OC)cc(OC)n2)C(=O)O)c1 10.1021/jm960274q
19085508 39584 None 0 Human Binding pKi = 6.7 6.7 218 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 466 7 1 8 4.2 COc1cc(OC)nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)n1 10.1016/s0960-894x(01)00791-0
CHEMBL147365 39584 None 0 Human Binding pKi = 6.7 6.7 218 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 466 7 1 8 4.2 COc1cc(OC)nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)n1 10.1016/s0960-894x(01)00791-0
CHEMBL315927 211192 None 0 Human Binding pKi = 6.7 6.7 - 1
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2cccc3ccccc23)NC1=O 10.1016/0960-894X(95)00019-P
10505434 4664 None 0 Human Binding pKi = 7.6 7.6 7 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 496 11 1 5 5.8 Cc1ccc(CCCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL103190 4664 None 0 Human Binding pKi = 7.6 7.6 7 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 496 11 1 5 5.8 Cc1ccc(CCCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
11801906 98526 None 0 Human Binding pKi = 6.6 6.6 -1 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 612 13 1 8 6.2 COc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(OC)c(OC)c2)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)n1 10.1021/jm9910425
CHEMBL276288 98526 None 0 Human Binding pKi = 6.6 6.6 -1 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 612 13 1 8 6.2 COc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(OC)c(OC)c2)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)n1 10.1021/jm9910425
44311698 204108 None 0 Human Binding pKi = 5.6 5.6 -524 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 574 10 3 4 5.3 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccccn3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
CHEMBL70310 204108 None 0 Human Binding pKi = 5.6 5.6 -524 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 574 10 3 4 5.3 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccccn3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
10670662 203446 None 0 Human Binding pKi = 7.6 7.6 53 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 9 1 7 3.5 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2cccc(C)c2)c2cccc(C)c2)n1 10.1021/jm960274q
CHEMBL65833 203446 None 0 Human Binding pKi = 7.6 7.6 53 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 9 1 7 3.5 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2cccc(C)c2)c2cccc(C)c2)n1 10.1021/jm960274q
CHEMBL87296 215893 None 0 Human Binding pKi = 5.6 5.6 - 1
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC1=O 10.1016/0960-894X(95)00019-P
10645256 41038 None 0 Rat Binding pKi = 4.6 4.6 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 410 6 1 4 5.2 CC(C)Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc3c2CCCC3)cc1 10.1021/jm970872k
CHEMBL148757 41038 None 0 Rat Binding pKi = 4.6 4.6 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 410 6 1 4 5.2 CC(C)Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc3c2CCCC3)cc1 10.1021/jm970872k
10552683 203109 None 0 Human Binding pKi = 6.6 6.6 5 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 478 9 1 7 4.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)n1 10.1021/jm960274q
CHEMBL64009 203109 None 0 Human Binding pKi = 6.6 6.6 5 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 478 9 1 7 4.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)n1 10.1021/jm960274q
18660522 119650 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccncn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL346862 119650 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccncn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
46228116 201220 None 0 Mouse Binding pKi = 7.6 7.6 2 2
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 598 10 1 9 4.6 COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCBr)cc2)cc(OC)c1OC 10.1016/j.bmc.2009.08.058
CHEMBL603635 201220 None 0 Mouse Binding pKi = 7.6 7.6 2 2
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 598 10 1 9 4.6 COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCBr)cc2)cc(OC)c1OC 10.1016/j.bmc.2009.08.058
3921421 107297 None 8 Human Binding pKi = 7.6 7.6 9 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 468 10 1 5 5.1 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccccc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
CHEMBL317233 107297 None 8 Human Binding pKi = 7.6 7.6 9 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 468 10 1 5 5.1 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccccc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
44314832 161271 None 0 Pig Binding pKi = 6.6 6.6 -251 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1496 45 18 17 0.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
CHEMBL412065 161271 None 0 Pig Binding pKi = 6.6 6.6 -251 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1496 45 18 17 0.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
44274960 99561 None 0 Human Binding pKi = 6.6 6.6 12 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 450 10 1 6 4.9 COc1cc(OC)nc(CC(C(=O)O)C(C)(Oc2ccc(C(C)C)cc2)c2ccccc2)n1 10.1021/jm030480f
CHEMBL283637 99561 None 0 Human Binding pKi = 6.6 6.6 12 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 450 10 1 6 4.9 COc1cc(OC)nc(CC(C(=O)O)C(C)(Oc2ccc(C(C)C)cc2)c2ccccc2)n1 10.1021/jm030480f
44311699 204167 None 0 Human Binding pKi = 6.6 6.6 -331 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 563 10 3 4 5.5 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccco3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
CHEMBL70686 204167 None 0 Human Binding pKi = 6.6 6.6 -331 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 563 10 3 4 5.5 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccco3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
44307412 203656 None 0 Human Binding pKi = 6.6 6.6 12 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 466 10 0 8 4.5 COC(=O)C(Oc1nc(OC)cc(OC)n1)C(C)(Oc1ccc(C(C)C)cc1)c1ccccc1 10.1021/jm960274q
CHEMBL67325 203656 None 0 Human Binding pKi = 6.6 6.6 12 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 466 10 0 8 4.5 COC(=O)C(Oc1nc(OC)cc(OC)n1)C(C)(Oc1ccc(C(C)C)cc1)c1ccccc1 10.1021/jm960274q
10721484 107359 None 0 Human Binding pKi = 6.6 6.6 -1 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 554 13 1 6 6.3 CCc1ccc(C(OCCc2ccc(OC)cc2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL317716 107359 None 0 Human Binding pKi = 6.6 6.6 -1 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 554 13 1 6 6.3 CCc1ccc(C(OCCc2ccc(OC)cc2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
10621777 43072 None 0 Rat Binding pKi = 5.6 5.6 12 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 415 7 1 6 4.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1[N+](=O)[O-] 10.1021/jm970872k
CHEMBL150481 43072 None 0 Rat Binding pKi = 5.6 5.6 12 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 415 7 1 6 4.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1[N+](=O)[O-] 10.1021/jm970872k
9797546 40890 None 0 Human Binding pKi = 6.6 6.6 - 1
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 329 4 1 5 3.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccnc2)c1C 10.1021/jm970872k
CHEMBL148637 40890 None 0 Human Binding pKi = 6.6 6.6 - 1
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 329 4 1 5 3.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccnc2)c1C 10.1021/jm970872k
22103537 42070 None 0 Human Binding pKi = 6.6 6.6 144 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 395 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccno3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL149592 42070 None 0 Human Binding pKi = 6.6 6.6 144 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 395 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccno3)cc2)c1C 10.1016/s0960-894x(01)00791-0
44312023 204462 None 0 Human Binding pKi = 4.6 4.6 -22 2
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL72295 204462 None 0 Human Binding pKi = 4.6 4.6 -22 2
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
10595347 42479 None 0 Rat Binding pKi = 7.6 7.6 537 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 370 6 1 4 4.7 CCCc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
CHEMBL149953 42479 None 0 Rat Binding pKi = 7.6 7.6 537 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 370 6 1 4 4.7 CCCc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
10741830 42841 None 0 Rat Binding pKi = 5.6 5.6 3 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 7 2 5 4.9 CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)c(-c2ccc(CC(C)C)cc2)c1 10.1021/jm970872k
CHEMBL150269 42841 None 0 Rat Binding pKi = 5.6 5.6 3 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 7 2 5 4.9 CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)c(-c2ccc(CC(C)C)cc2)c1 10.1021/jm970872k
15297287 164410 None 0 Human Binding pKi = 4.6 4.6 -3 2
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 424 5 2 4 5.2 O=C(O)CN1C(=O)c2ccccc2Nc2ccc(OCc3cccc4ccccc34)cc21 10.1016/0960-894X(95)00019-P
CHEMBL421349 164410 None 0 Human Binding pKi = 4.6 4.6 -3 2
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 424 5 2 4 5.2 O=C(O)CN1C(=O)c2ccccc2Nc2ccc(OCc3cccc4ccccc34)cc21 10.1016/0960-894X(95)00019-P
10599293 39023 None 0 Rat Binding pKi = 7.5 7.5 128 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 9 2 5 5.8 CCCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL146845 39023 None 0 Rat Binding pKi = 7.5 7.5 128 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 9 2 5 5.8 CCCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
10508342 4728 None 0 Human Binding pKi = 6.5 6.5 -1 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 638 13 1 8 6.3 COc1ccc(CCOC(c2ccc(Cl)cc2)(c2ccc(Cl)cc2)C(Oc2nc3c(c(OC)n2)CCC3)C(=O)O)cc1OC 10.1021/jm9910425
CHEMBL103605 4728 None 0 Human Binding pKi = 6.5 6.5 -1 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 638 13 1 8 6.3 COc1ccc(CCOC(c2ccc(Cl)cc2)(c2ccc(Cl)cc2)C(Oc2nc3c(c(OC)n2)CCC3)C(=O)O)cc1OC 10.1021/jm9910425
44311849 103071 None 0 Human Binding pKi = 8.5 8.5 -5 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 694 14 2 7 5.8 CCCCS(=O)(=O)NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL307384 103071 None 0 Human Binding pKi = 8.5 8.5 -5 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 694 14 2 7 5.8 CCCCS(=O)(=O)NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
11800649 4607 None 0 Human Binding pKi = 8.5 8.5 7 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 542 13 1 7 5.5 CCOc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
CHEMBL102797 4607 None 0 Human Binding pKi = 8.5 8.5 7 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 542 13 1 7 5.5 CCOc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
19085510 119553 None 0 Human Binding pKi = 8.5 8.5 6025 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 405 5 1 5 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cccnc3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL345951 119553 None 0 Human Binding pKi = 8.5 8.5 6025 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 405 5 1 5 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cccnc3)cc2)c1C 10.1016/s0960-894x(01)00791-0
10528863 4618 None 0 Human Binding pKi = 8.5 8.5 4 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 484 10 2 6 4.8 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(O)cc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
CHEMBL102868 4618 None 0 Human Binding pKi = 8.5 8.5 4 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 484 10 2 6 4.8 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(O)cc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
6433100 4547 None 7 Human Binding pKi = 8.5 8.5 2 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
CHEMBL102405 4547 None 7 Human Binding pKi = 8.5 8.5 2 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
51003353 58064 None 0 Mouse Binding pKi = 8.5 8.5 10 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 886 26 1 17 5.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CCCCOc4cccnc4F)nn3)c2)cc1 10.1021/jm101110w
CHEMBL1672883 58064 None 0 Mouse Binding pKi = 8.5 8.5 10 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 886 26 1 17 5.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CCCCOc4cccnc4F)nn3)c2)cc1 10.1021/jm101110w
10548722 5478 None 0 Human Binding pKi = 8.4 8.4 20892 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 395 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cnco3)cc2)c1C 10.1021/jm000105c
CHEMBL107574 5478 None 0 Human Binding pKi = 8.4 8.4 20892 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 395 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cnco3)cc2)c1C 10.1021/jm000105c
44311726 103083 None 0 Human Binding pKi = 8.4 8.4 -10 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 667 12 3 7 4.8 C/C=C/S(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL307471 103083 None 0 Human Binding pKi = 8.4 8.4 -10 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 667 12 3 7 4.8 C/C=C/S(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
51003354 58065 None 0 Mouse Binding pKi = 8.4 8.4 74 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 920 24 1 17 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CN(C)S(=O)(=O)c4ccc(F)cc4)nn3)c2)cc1 10.1021/jm101110w
CHEMBL1672884 58065 None 0 Mouse Binding pKi = 8.4 8.4 74 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 920 24 1 17 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CN(C)S(=O)(=O)c4ccc(F)cc4)nn3)c2)cc1 10.1021/jm101110w
18660523 41824 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cncnc3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL149340 41824 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cncnc3)cc2)c1C 10.1016/s0960-894x(01)00791-0
10525034 119672 None 0 Rat Binding pKi = 7.5 7.5 89 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 7 1 5 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OCC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL347125 119672 None 0 Rat Binding pKi = 7.5 7.5 89 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 7 1 5 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OCC(C)C)cc2)c1C 10.1021/jm970872k
10505357 109401 None 0 Human Binding pKi = 7.5 7.5 10 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 494 10 1 5 5.9 Cc1ccc(/C=C/COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL321984 109401 None 0 Human Binding pKi = 7.5 7.5 10 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 494 10 1 5 5.9 Cc1ccc(/C=C/COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
10624645 4331 None 0 Human Binding pKi = 7.5 7.5 1 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 482 10 1 5 5.4 Cc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL100954 4331 None 0 Human Binding pKi = 7.5 7.5 1 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 482 10 1 5 5.4 Cc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
10713411 164943 None 0 Rat Binding pKi = 7.5 7.5 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 358 5 1 5 3.8 COc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
CHEMBL422496 164943 None 0 Rat Binding pKi = 7.5 7.5 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 358 5 1 5 3.8 COc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
10671031 102692 None 0 Human Binding pKi = 7.5 7.5 29 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 446 9 1 7 3.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(F)cc2)c2ccc(F)cc2)n1 10.1021/jm960274q
CHEMBL304721 102692 None 0 Human Binding pKi = 7.5 7.5 29 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 446 9 1 7 3.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(F)cc2)c2ccc(F)cc2)n1 10.1021/jm960274q
10622410 44027 None 0 Rat Binding pKi = 6.5 6.5 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 7 1 5 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2N(C)C)c1C 10.1021/jm970872k
CHEMBL151395 44027 None 0 Rat Binding pKi = 6.5 6.5 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 7 1 5 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2N(C)C)c1C 10.1021/jm970872k
19934534 106693 None 0 Human Binding pKi = 4.5 4.5 -5 2
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 468 6 3 4 5.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3cc4ccccc4[nH]3)ccc21 10.1016/0960-894X(95)00019-P
CHEMBL314364 106693 None 0 Human Binding pKi = 4.5 4.5 -5 2
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 468 6 3 4 5.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3cc4ccccc4[nH]3)ccc21 10.1016/0960-894X(95)00019-P
10741834 44041 None 0 Rat Binding pKi = 7.5 7.5 85 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 8 2 5 5.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NC(C)C)c1C 10.1021/jm970872k
CHEMBL151422 44041 None 0 Rat Binding pKi = 7.5 7.5 85 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 8 2 5 5.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NC(C)C)c1C 10.1021/jm970872k
9864017 41326 None 0 Human Binding pKi = 6.5 6.5 194 2
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 367 4 2 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2cc3ccccc3[nH]2)c1C 10.1021/jm970872k
CHEMBL148967 41326 None 0 Human Binding pKi = 6.5 6.5 194 2
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 367 4 2 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2cc3ccccc3[nH]2)c1C 10.1021/jm970872k
10743346 102609 None 0 Human Binding pKi = 6.5 6.5 4 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 480 11 1 7 4.7 COc1cc(OC)nc(OC(C(=O)O)C(OCCC(C)(C)C)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
CHEMBL304173 102609 None 0 Human Binding pKi = 6.5 6.5 4 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 480 11 1 7 4.7 COc1cc(OC)nc(OC(C(=O)O)C(OCCC(C)(C)C)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
10709109 44128 None 0 Rat Binding pKi = 5.5 5.5 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2ccccc2[N+](=O)[O-])c1C 10.1021/jm970872k
CHEMBL151545 44128 None 0 Rat Binding pKi = 5.5 5.5 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2ccccc2[N+](=O)[O-])c1C 10.1021/jm970872k
10691438 44490 None 0 Rat Binding pKi = 7.4 7.4 51 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 7 1 4 5.1 CCCCc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
CHEMBL151926 44490 None 0 Rat Binding pKi = 7.4 7.4 51 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 7 1 4 5.1 CCCCc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
44213540 39479 None 0 Human Binding pKi = 7.4 7.4 831 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 421 5 1 5 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cccc[n+]3[O-])cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL147238 39479 None 0 Human Binding pKi = 7.4 7.4 831 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 421 5 1 5 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cccc[n+]3[O-])cc2)c1C 10.1016/s0960-894x(01)00791-0
10693130 121967 None 0 Rat Binding pKi = 6.4 6.4 16 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 1 5 5.0 COc1ccc(S(=O)(=O)Nc2onc(C)c2C)c(-c2ccc(CC(C)C)cc2)c1 10.1021/jm970872k
CHEMBL359152 121967 None 0 Rat Binding pKi = 6.4 6.4 16 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 1 5 5.0 COc1ccc(S(=O)(=O)Nc2onc(C)c2C)c(-c2ccc(CC(C)C)cc2)c1 10.1021/jm970872k
44365561 42268 None 0 Human Binding pKi = 7.4 7.4 524 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 404 5 1 4 5.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccccc3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL149763 42268 None 0 Human Binding pKi = 7.4 7.4 524 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 404 5 1 4 5.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccccc3)cc2)c1C 10.1016/s0960-894x(01)00791-0
44365878 42284 None 0 Human Binding pKi = 5.4 5.4 - 1
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 396 5 2 7 2.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nn[nH]n3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL149778 42284 None 0 Human Binding pKi = 5.4 5.4 - 1
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 396 5 2 7 2.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nn[nH]n3)cc2)c1C 10.1016/s0960-894x(01)00791-0
10501299 119852 None 0 Rat Binding pKi = 7.4 7.4 147 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 402 6 1 5 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(SC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL348685 119852 None 0 Rat Binding pKi = 7.4 7.4 147 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 402 6 1 5 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(SC(C)C)cc2)c1C 10.1021/jm970872k
11813485 18087 None 0 Human Binding pKi = 7.4 7.4 -8 2
Compound was evaluated for its binding affinity towards human Endothelin A receptorCompound was evaluated for its binding affinity towards human Endothelin A receptor
ChEMBL 534 9 1 6 6.0 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm020138n
CHEMBL126755 18087 None 0 Human Binding pKi = 7.4 7.4 -8 2
Compound was evaluated for its binding affinity towards human Endothelin A receptorCompound was evaluated for its binding affinity towards human Endothelin A receptor
ChEMBL 534 9 1 6 6.0 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm020138n
10769887 107490 None 0 Human Binding pKi = 7.4 7.4 1 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 600 15 1 8 6.0 CCc1ccc(C(OCCc2ccc(OC)c(OC)c2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL318535 107490 None 0 Human Binding pKi = 7.4 7.4 1 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 600 15 1 8 6.0 CCc1ccc(C(OCCc2ccc(OC)c(OC)c2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 10.1021/jm9910425
10526510 121066 None 0 Rat Binding pKi = 5.4 5.4 12 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 8 1 6 4.2 COc1cc(OC)nc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)n1 10.1021/jm970872k
CHEMBL356972 121066 None 0 Rat Binding pKi = 5.4 5.4 12 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 8 1 6 4.2 COc1cc(OC)nc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)n1 10.1021/jm970872k
22103385 121083 None 0 Human Binding pKi = 8.4 8.4 19054 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 396 5 1 7 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nnco3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL357077 121083 None 0 Human Binding pKi = 8.4 8.4 19054 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 396 5 1 7 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nnco3)cc2)c1C 10.1016/s0960-894x(01)00791-0
20747574 12105 None 0 Human Binding pKi = 8.4 8.4 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 565 12 2 8 4.8 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 10.1016/s0960-894x(03)00018-0
CHEMBL11840 12105 None 0 Human Binding pKi = 8.4 8.4 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 565 12 2 8 4.8 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 10.1016/s0960-894x(03)00018-0
9807200 85343 None 0 Human Binding pKi = 8.4 8.4 346 2
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261359 85343 None 0 Human Binding pKi = 8.4 8.4 346 2
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)[C@@H](c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
51003352 58063 None 0 Mouse Binding pKi = 8.4 8.4 1230 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 1020 35 1 21 4.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCOCc3cn(CCOCCOCCOCCOc4cccnc4F)nn3)c2)cc1 10.1021/jm101110w
CHEMBL1672882 58063 None 0 Mouse Binding pKi = 8.4 8.4 1230 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 1020 35 1 21 4.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCOCc3cn(CCOCCOCCOCCOc4cccnc4F)nn3)c2)cc1 10.1021/jm101110w
9908909 5307 None 11 Rat Binding pKi = 8.3 8.3 -1 3
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 399 6 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2N)c1C 10.1021/jm970872k
CHEMBL106684 5307 None 11 Rat Binding pKi = 8.3 8.3 -1 3
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 399 6 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2N)c1C 10.1021/jm970872k
10811477 4816 None 0 Human Binding pKi = 8.3 8.3 19952 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncoc3C)cc2)c1C 10.1021/jm000105c
CHEMBL104172 4816 None 0 Human Binding pKi = 8.3 8.3 19952 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncoc3C)cc2)c1C 10.1021/jm000105c
9908909 5307 None 11 Human Binding pKi = 8.3 8.3 1 3
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 399 6 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2N)c1C 10.1021/jm000105c
CHEMBL106684 5307 None 11 Human Binding pKi = 8.3 8.3 1 3
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 399 6 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2N)c1C 10.1021/jm000105c
443289 710 None 47 Rat Binding pKi = 7.4 7.4 -2 3
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL None None None None 10.1021/jm970872k
997 710 None 47 Rat Binding pKi = 7.4 7.4 -2 3
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL None None None None 10.1021/jm970872k
CHEMBL314691 710 None 47 Rat Binding pKi = 7.4 7.4 -2 3
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL None None None None 10.1021/jm970872k
DB12054 710 None 47 Rat Binding pKi = 7.4 7.4 -2 3
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL None None None None 10.1021/jm970872k
9950670 43554 None 0 Rat Binding pKi = 7.4 7.4 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 358 5 2 5 3.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2CO)c1C 10.1021/jm970872k
CHEMBL150891 43554 None 0 Rat Binding pKi = 7.4 7.4 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 358 5 2 5 3.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2CO)c1C 10.1021/jm970872k
18004820 16451 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 527 9 2 7 4.7 CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
CHEMBL12333 16451 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 527 9 2 7 4.7 CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
10208527 98194 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 526 9 1 7 5.8 CCCc1nc(Cl)c(C(C)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
CHEMBL274154 98194 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 526 9 1 7 5.8 CCCc1nc(Cl)c(C(C)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
11795351 42847 None 0 Rat Binding pKi = 6.4 6.4 109 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 401 6 1 4 4.8 CC(C)Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc(Cl)nn2)cc1 10.1021/jm970872k
CHEMBL150273 42847 None 0 Rat Binding pKi = 6.4 6.4 109 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 401 6 1 4 4.8 CC(C)Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc(Cl)nn2)cc1 10.1021/jm970872k
44303148 203155 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 456 4 1 5 5.1 O=C1O[C@@](O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)C1c1ccc2c(c1)OCO2 10.1021/jm990504b
CHEMBL64200 203155 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 456 4 1 5 5.1 O=C1O[C@@](O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)C1c1ccc2c(c1)OCO2 10.1021/jm990504b
19934549 105991 None 0 Human Binding pKi = 4.4 4.4 -3 2
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 439 6 2 3 5.4 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(Cc3c[nH]c4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
CHEMBL313184 105991 None 0 Human Binding pKi = 4.4 4.4 -3 2
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 439 6 2 3 5.4 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(Cc3c[nH]c4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
10280531 162929 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 541 10 2 7 5.1 CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
CHEMBL417429 162929 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 541 10 2 7 5.1 CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
10528341 14575 None 0 Rat Binding pKi = 7.4 7.4 95 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 458 9 2 6 4.4 Cc1noc(NS(=O)(=O)c2cccc(OCC(=O)O)c2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL1204523 14575 None 0 Rat Binding pKi = 7.4 7.4 95 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 458 9 2 6 4.4 Cc1noc(NS(=O)(=O)c2cccc(OCC(=O)O)c2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL149152 14575 None 0 Rat Binding pKi = 7.4 7.4 95 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 458 9 2 6 4.4 Cc1noc(NS(=O)(=O)c2cccc(OCC(=O)O)c2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
155543936 173233 None 0 Rat Binding pKi = 5.4 5.4 -218776 2
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL 2514 48 34 38 -9.8 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CC(N)=O)NC2=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00087a001
CHEMBL4524100 173233 None 0 Rat Binding pKi = 5.4 5.4 -218776 2
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL 2514 48 34 38 -9.8 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CC(N)=O)NC2=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00087a001
10407051 100391 None 0 Human Binding pKi = 6.4 6.4 5 2
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 374 5 1 3 4.7 COc1ccc([C@H]2c3ccccc3[C@@H](c3ccc(OC)cc3)[C@@H]2C(=O)O)cc1 10.1021/jm00037a003
CHEMBL290026 100391 None 0 Human Binding pKi = 6.4 6.4 5 2
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 374 5 1 3 4.7 COc1ccc([C@H]2c3ccccc3[C@@H](c3ccc(OC)cc3)[C@@H]2C(=O)O)cc1 10.1021/jm00037a003
10647471 42323 None 0 Rat Binding pKi = 7.4 7.4 125 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 456 7 3 5 4.7 CNC(=O)Nc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL149818 42323 None 0 Rat Binding pKi = 7.4 7.4 125 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 456 7 3 5 4.7 CNC(=O)Nc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
10045790 141650 None 0 Human Binding pKi = 7.4 7.4 17 2
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 388 4 1 4 4.4 COc1ccc([C@H]2c3ccccc3[C@@H](c3ccc4c(c3)OCO4)[C@@H]2C(=O)O)cc1 10.1021/jm00037a003
CHEMBL38537 141650 None 0 Human Binding pKi = 7.4 7.4 17 2
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 388 4 1 4 4.4 COc1ccc([C@H]2c3ccccc3[C@@H](c3ccc4c(c3)OCO4)[C@@H]2C(=O)O)cc1 10.1021/jm00037a003
22103589 41174 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 394 5 2 5 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncc[nH]3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL148855 41174 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 394 5 2 5 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncc[nH]3)cc2)c1C 10.1016/s0960-894x(01)00791-0
3887 2070 None 45 Pig Binding pKi = 6.4 6.4 -436 4
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL None None None None 10.1016/0960-894X(96)00421-0
5311192 2070 None 45 Pig Binding pKi = 6.4 6.4 -436 4
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL None None None None 10.1016/0960-894X(96)00421-0
CHEMBL72410 2070 None 45 Pig Binding pKi = 6.4 6.4 -436 4
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL None None None None 10.1016/0960-894X(96)00421-0
3887 2070 None 45 Human Binding pKi = 6.4 6.4 -436 4
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL None None None None 10.1016/s0960-894x(98)00387-4
5311192 2070 None 45 Human Binding pKi = 6.4 6.4 -436 4
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL None None None None 10.1016/s0960-894x(98)00387-4
CHEMBL72410 2070 None 45 Human Binding pKi = 6.4 6.4 -436 4
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL None None None None 10.1016/s0960-894x(98)00387-4
10499516 120976 None 0 Rat Binding pKi = 5.4 5.4 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 372 5 2 5 3.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(=O)O)cc2)c1C 10.1021/jm970872k
CHEMBL356220 120976 None 0 Rat Binding pKi = 5.4 5.4 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 372 5 2 5 3.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(=O)O)cc2)c1C 10.1021/jm970872k
44311701 168154 None 1 Human Binding pKi = 7.4 7.4 -213 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 564 10 3 5 4.9 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
CHEMBL433106 168154 None 1 Human Binding pKi = 7.4 7.4 -213 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 564 10 3 5 4.9 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
10280562 15513 None 0 Human Binding pKi = 6.3 6.3 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 542 9 1 8 5.4 CCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
CHEMBL12172 15513 None 0 Human Binding pKi = 6.3 6.3 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 542 9 1 8 5.4 CCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
10516176 205198 None 3 Rat Binding pKi = 5.3 5.3 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccccc2F)c1C 10.1021/jm970872k
CHEMBL78499 205198 None 3 Rat Binding pKi = 5.3 5.3 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccccc2F)c1C 10.1021/jm970872k
10793160 98404 None 0 Human Binding pKi = 7.3 7.3 -2 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 570 13 1 8 5.6 COc1cc(/C=C/COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc(OC)c1OC 10.1021/jm9910425
CHEMBL275471 98404 None 0 Human Binding pKi = 7.3 7.3 -2 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 570 13 1 8 5.6 COc1cc(/C=C/COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc(OC)c1OC 10.1021/jm9910425
122272 97095 None 31 Human Binding pKi = 7.3 7.3 1 2
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm9505369
CHEMBL267458 97095 None 31 Human Binding pKi = 7.3 7.3 1 2
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm9505369
122272 97095 None 31 Human Binding pKi = 7.3 7.3 1 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm980217s
CHEMBL267458 97095 None 31 Human Binding pKi = 7.3 7.3 1 2
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm980217s
10810897 121491 None 0 Rat Binding pKi = 8.3 8.3 3801 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 6 1 4 5.3 Cc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL358254 121491 None 0 Rat Binding pKi = 8.3 8.3 3801 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 6 1 4 5.3 Cc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
10621010 164860 None 0 Rat Binding pKi = 8.3 8.3 186 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 6 2 5 4.7 Cc1noc(NS(=O)(=O)c2cccc(O)c2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL421955 164860 None 0 Rat Binding pKi = 8.3 8.3 186 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 6 2 5 4.7 Cc1noc(NS(=O)(=O)c2cccc(O)c2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
9871837 15201 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 535 10 2 7 4.9 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/s0960-894x(03)00018-0
CHEMBL12106 15201 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 535 10 2 7 4.9 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/s0960-894x(03)00018-0
9985001 97007 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 549 10 2 7 5.2 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/s0960-894x(03)00018-0
CHEMBL266628 97007 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 549 10 2 7 5.2 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/s0960-894x(03)00018-0
44311772 103031 None 0 Human Binding pKi = 8.3 8.3 -10 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 628 15 2 8 4.1 CCCCS(=O)(=O)NC(=O)C(CCSC)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL307045 103031 None 0 Human Binding pKi = 8.3 8.3 -10 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 628 15 2 8 4.1 CCCCS(=O)(=O)NC(=O)C(CCSC)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
44311838 204616 None 0 Human Binding pKi = 8.3 8.3 -13 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 655 12 3 7 4.3 CCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL73373 204616 None 0 Human Binding pKi = 8.3 8.3 -13 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 655 12 3 7 4.3 CCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
44311850 103189 None 0 Human Binding pKi = 8.3 8.3 -10 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 717 13 3 7 5.5 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)Cc2ccccc2)c1 10.1016/s0960-894x(98)00387-4
CHEMBL308269 103189 None 0 Human Binding pKi = 8.3 8.3 -10 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 717 13 3 7 5.5 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)Cc2ccccc2)c1 10.1016/s0960-894x(98)00387-4
44311773 204676 None 0 Human Binding pKi = 8.3 8.3 -7 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 582 13 2 7 3.8 CCCCS(=O)(=O)NC(=O)C(CC)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL73835 204676 None 0 Human Binding pKi = 8.3 8.3 -7 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 582 13 2 7 3.8 CCCCS(=O)(=O)NC(=O)C(CC)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
22103743 42834 None 0 Human Binding pKi = 8.3 8.3 9332 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 411 5 1 6 4.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nccs3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL150260 42834 None 0 Human Binding pKi = 8.3 8.3 9332 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 411 5 1 6 4.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nccs3)cc2)c1C 10.1016/s0960-894x(01)00791-0
10667808 119289 None 0 Rat Binding pKi = 7.3 7.3 338 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 385 6 2 5 4.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(NC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL343867 119289 None 0 Rat Binding pKi = 7.3 7.3 338 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 385 6 2 5 4.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(NC(C)C)cc2)c1C 10.1021/jm970872k
10761688 119853 None 0 Rat Binding pKi = 7.3 7.3 380 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 370 5 1 4 4.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL348700 119853 None 0 Rat Binding pKi = 7.3 7.3 380 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 370 5 1 4 4.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(C)C)cc2)c1C 10.1021/jm970872k
10501166 41876 None 0 Rat Binding pKi = 6.3 6.3 47 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 6 2 5 4.7 Cc1noc(NS(=O)(=O)c2cc(O)ccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL149391 41876 None 0 Rat Binding pKi = 6.3 6.3 47 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 6 2 5 4.7 Cc1noc(NS(=O)(=O)c2cc(O)ccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
44314444 161720 None 0 Pig Binding pKi = 5.3 5.3 -457 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1470 45 18 17 -0.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
CHEMBL413604 161720 None 0 Pig Binding pKi = 5.3 5.3 -457 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1470 45 18 17 -0.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
9799352 121105 None 0 Human Binding pKi = 6.3 6.3 - 1
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 367 4 2 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2c[nH]c3ccccc23)c1C 10.1021/jm970872k
CHEMBL357331 121105 None 0 Human Binding pKi = 6.3 6.3 - 1
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 367 4 2 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2c[nH]c3ccccc23)c1C 10.1021/jm970872k
10690608 121057 None 0 Rat Binding pKi = 7.3 7.3 112 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 371 5 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(N(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL356901 121057 None 0 Rat Binding pKi = 7.3 7.3 112 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 371 5 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(N(C)C)cc2)c1C 10.1021/jm970872k
44311700 102820 None 0 Human Binding pKi = 7.3 7.3 -234 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 579 10 3 4 6.0 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccsc3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
CHEMBL305462 102820 None 0 Human Binding pKi = 7.3 7.3 -234 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 579 10 3 4 6.0 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccsc3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
122272 97095 None 31 Rat Binding pKi = 7.3 7.3 -1 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm970872k
CHEMBL267458 97095 None 31 Rat Binding pKi = 7.3 7.3 -1 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm970872k
10521258 121294 None 0 Rat Binding pKi = 7.3 7.3 416 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 342 4 1 4 4.1 Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
CHEMBL358020 121294 None 0 Rat Binding pKi = 7.3 7.3 416 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 342 4 1 4 4.1 Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
122272 97095 None 31 Human Binding pKi = 7.3 7.3 1 2
Binding affinity towards ET1 receptor was determined in A10 cellsBinding affinity towards ET1 receptor was determined in A10 cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00029a001
CHEMBL267458 97095 None 31 Human Binding pKi = 7.3 7.3 1 2
Binding affinity towards ET1 receptor was determined in A10 cellsBinding affinity towards ET1 receptor was determined in A10 cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00029a001
10166104 15175 None 0 Human Binding pKi = 7.3 7.3 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 549 10 1 7 5.2 CCCc1nc(CC)c(C(=O)N(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
CHEMBL12102 15175 None 0 Human Binding pKi = 7.3 7.3 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 549 10 1 7 5.2 CCCc1nc(CC)c(C(=O)N(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
17979745 17917 None 0 Human Binding pKi = 7.3 7.3 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 521 10 2 7 4.6 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
CHEMBL12592 17917 None 0 Human Binding pKi = 7.3 7.3 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 521 10 2 7 4.6 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
122272 97095 None 31 Human Binding pKi = 7.3 7.3 1 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm000105c
CHEMBL267458 97095 None 31 Human Binding pKi = 7.3 7.3 1 2
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm000105c
10718666 121519 None 0 Rat Binding pKi = 6.3 6.3 3 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 457 9 3 6 4.5 Cc1noc(NS(=O)(=O)c2ccc(NCC(=O)O)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL358461 121519 None 0 Rat Binding pKi = 6.3 6.3 3 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 457 9 3 6 4.5 Cc1noc(NS(=O)(=O)c2ccc(NCC(=O)O)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
10670536 121085 None 0 Rat Binding pKi = 6.3 6.3 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 435 6 1 6 3.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(S(=O)(=O)N(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL357099 121085 None 0 Rat Binding pKi = 6.3 6.3 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 435 6 1 6 3.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(S(=O)(=O)N(C)C)cc2)c1C 10.1021/jm970872k
10088869 144354 None 0 Human Binding pKi = 5.3 5.3 - 1
Inhibition of [125I]ET1 binding to cloned human Endothelin A receptorInhibition of [125I]ET1 binding to cloned human Endothelin A receptor
ChEMBL 344 4 1 2 4.7 COc1ccc([C@H]2c3ccccc3[C@@H](c3ccccc3)[C@@H]2C(=O)O)cc1 10.1021/jm00037a003
CHEMBL39057 144354 None 0 Human Binding pKi = 5.3 5.3 - 1
Inhibition of [125I]ET1 binding to cloned human Endothelin A receptorInhibition of [125I]ET1 binding to cloned human Endothelin A receptor
ChEMBL 344 4 1 2 4.7 COc1ccc([C@H]2c3ccccc3[C@@H](c3ccccc3)[C@@H]2C(=O)O)cc1 10.1021/jm00037a003
10839202 119234 None 0 Rat Binding pKi = 5.2 5.2 6 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 503 8 2 5 6.2 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL343477 119234 None 0 Rat Binding pKi = 5.2 5.2 6 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 503 8 2 5 6.2 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
10563752 40966 None 2 Rat Binding pKi = 5.2 5.2 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccccc2N)c1C 10.1021/jm970872k
CHEMBL148702 40966 None 2 Rat Binding pKi = 5.2 5.2 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccccc2N)c1C 10.1021/jm970872k
9953358 94798 None 13 Human Binding pKi = 8.2 8.2 102 2
Binding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, poBinding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, po
ChEMBL 410 9 1 7 2.9 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm030480f
CHEMBL25344 94798 None 13 Human Binding pKi = 8.2 8.2 102 2
Binding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, poBinding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, po
ChEMBL 410 9 1 7 2.9 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm030480f
44311803 204552 None 0 Human Binding pKi = 8.2 8.2 -26 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 699 15 3 8 4.3 CCOCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL72924 204552 None 0 Human Binding pKi = 8.2 8.2 -26 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 699 15 3 8 4.3 CCOCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
177236 1324 None 45 Rat Binding pKi = 8.2 8.2 -2 3
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030528p
3508 1324 None 45 Rat Binding pKi = 8.2 8.2 -2 3
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030528p
CHEMBL23261 1324 None 45 Rat Binding pKi = 8.2 8.2 -2 3
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030528p
DB04883 1324 None 45 Rat Binding pKi = 8.2 8.2 -2 3
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030528p
9953358 94798 None 13 Human Binding pKi = 8.2 8.2 102 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 410 9 1 7 2.9 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
CHEMBL25344 94798 None 13 Human Binding pKi = 8.2 8.2 102 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 410 9 1 7 2.9 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
177236 1324 None 45 Human Binding pKi = 8.2 8.2 2 3
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
3508 1324 None 45 Human Binding pKi = 8.2 8.2 2 3
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
CHEMBL23261 1324 None 45 Human Binding pKi = 8.2 8.2 2 3
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
DB04883 1324 None 45 Human Binding pKi = 8.2 8.2 2 3
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
11006149 101096 None 0 Human Binding pKi = 8.2 8.2 380 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 550 8 1 7 6.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C(=O)C(C)(C)C)C(C)C)c1C 10.1021/jm020289q
CHEMBL29502 101096 None 0 Human Binding pKi = 8.2 8.2 380 2
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 550 8 1 7 6.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C(=O)C(C)(C)C)C(C)C)c1C 10.1021/jm020289q
10648996 4352 None 0 Human Binding pKi = 8.2 8.2 3 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 498 11 1 6 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL101069 4352 None 0 Human Binding pKi = 8.2 8.2 3 2
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 498 11 1 6 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
18660520 39562 None 0 Human Binding pKi = 8.2 8.2 3548 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cnccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL147340 39562 None 0 Human Binding pKi = 8.2 8.2 3548 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cnccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
10741151 43065 None 0 Rat Binding pKi = 8.2 8.2 223 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 8 2 5 5.4 CCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL150474 43065 None 0 Rat Binding pKi = 8.2 8.2 223 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 8 2 5 5.4 CCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
10503421 119507 None 0 Rat Binding pKi = 8.2 8.2 245 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 443 9 3 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NCCO)c1C 10.1021/jm970872k
CHEMBL345542 119507 None 0 Rat Binding pKi = 8.2 8.2 245 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 443 9 3 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NCCO)c1C 10.1021/jm970872k
104865 705 None 99 Human Binding pKi = 8.2 8.2 1 4
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm970101g
3494 705 None 99 Human Binding pKi = 8.2 8.2 1 4
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm970101g
392 705 None 99 Human Binding pKi = 8.2 8.2 1 4
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm970101g
CHEMBL957 705 None 99 Human Binding pKi = 8.2 8.2 1 4
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm970101g
DB00559 705 None 99 Human Binding pKi = 8.2 8.2 1 4
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm970101g
104865 705 None 99 Rat Binding pKi = 8.2 8.2 -1 4
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm030528p
3494 705 None 99 Rat Binding pKi = 8.2 8.2 -1 4
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm030528p
392 705 None 99 Rat Binding pKi = 8.2 8.2 -1 4
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm030528p
CHEMBL957 705 None 99 Rat Binding pKi = 8.2 8.2 -1 4
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm030528p
DB00559 705 None 99 Rat Binding pKi = 8.2 8.2 -1 4
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm030528p
44265871 166916 None 0 Human Binding pKi = 8.2 8.2 53 2
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 547 10 2 8 4.6 COc1ccccc1Cc1c(CCCO)nc(-c2ncccn2)nc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1021/jm9505369
CHEMBL428661 166916 None 0 Human Binding pKi = 8.2 8.2 53 2
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 547 10 2 8 4.6 COc1ccccc1Cc1c(CCCO)nc(-c2ncccn2)nc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1021/jm9505369
22103787 40990 None 0 Human Binding pKi = 8.2 8.2 1380 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 394 5 1 6 3.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-n3cccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL148719 40990 None 0 Human Binding pKi = 8.2 8.2 1380 2
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 394 5 1 6 3.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-n3cccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
44311989 204569 None 0 Human Binding pKi = 8.2 8.2 -1 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 610 14 2 7 4.4 CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)CC 10.1016/s0960-894x(98)00387-4
CHEMBL73042 204569 None 0 Human Binding pKi = 8.2 8.2 -1 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 610 14 2 7 4.4 CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)CC 10.1016/s0960-894x(98)00387-4
10620958 41707 None 0 Rat Binding pKi = 7.2 7.2 331 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 399 6 1 5 4.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(N(C)C(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL149241 41707 None 0 Rat Binding pKi = 7.2 7.2 331 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 399 6 1 5 4.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(N(C)C(C)C)cc2)c1C 10.1021/jm970872k
10803738 118986 None 0 Rat Binding pKi = 6.2 6.2 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 294 4 1 4 3.2 Cc1noc(NS(=O)(=O)c2ccccc2C(C)C)c1C 10.1021/jm970872k
CHEMBL342498 118986 None 0 Rat Binding pKi = 6.2 6.2 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 294 4 1 4 3.2 Cc1noc(NS(=O)(=O)c2ccccc2C(C)C)c1C 10.1021/jm970872k
5472495 186631 None 47 Human Binding pKi = 5.2 5.2 - 1
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 nan
CHEMBL488025 186631 None 47 Human Binding pKi = 5.2 5.2 - 1
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 nan
10691439 44541 None 0 Rat Binding pKi = 7.2 7.2 245 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 4 1 4 5.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(C)(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL151971 44541 None 0 Rat Binding pKi = 7.2 7.2 245 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 4 1 4 5.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(C)(C)C)cc2)c1C 10.1021/jm970872k
10783588 165680 None 0 Rat Binding pKi = 7.2 7.2 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 343 4 2 5 3.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(N)c2)c1C 10.1021/jm970872k
CHEMBL424504 165680 None 0 Rat Binding pKi = 7.2 7.2 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 343 4 2 5 3.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(N)c2)c1C 10.1021/jm970872k
44314783 166447 None 0 Pig Binding pKi = 6.2 6.2 -7943 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1576 47 19 18 0.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
77282213 166447 None 0 Pig Binding pKi = 6.2 6.2 -7943 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1576 47 19 18 0.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
CHEMBL427778 166447 None 0 Pig Binding pKi = 6.2 6.2 -7943 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1576 47 19 18 0.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
5310990 166828 None 11 Human Binding pKi = 7.2 7.2 - 1
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL428504 166828 None 11 Human Binding pKi = 7.2 7.2 - 1
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10600059 44517 None 0 Rat Binding pKi = 5.2 5.2 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 460 8 1 4 6.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1Cc1ccccc1 10.1021/jm970872k
CHEMBL151954 44517 None 0 Rat Binding pKi = 5.2 5.2 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 460 8 1 4 6.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1Cc1ccccc1 10.1021/jm970872k
9830098 103028 None 0 Human Binding pKi = 5.2 5.2 -5 2
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL307033 103028 None 0 Human Binding pKi = 5.2 5.2 -5 2
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
22574723 15936 None 0 Human Binding pKi = 8.2 8.2 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 549 11 2 7 5.2 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 10.1016/s0960-894x(03)00018-0
CHEMBL12233 15936 None 0 Human Binding pKi = 8.2 8.2 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 549 11 2 7 5.2 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 10.1016/s0960-894x(03)00018-0
20747575 98422 None 0 Human Binding pKi = 8.2 8.2 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 579 12 2 8 5.0 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 10.1016/s0960-894x(03)00018-0
CHEMBL275545 98422 None 0 Human Binding pKi = 8.2 8.2 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 579 12 2 8 5.0 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 10.1016/s0960-894x(03)00018-0
10693607 102704 None 0 Human Binding pKi = 8.2 8.2 354 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 424 10 1 7 3.3 CCOC(c1ccccc1)(c1ccccc1)C(Oc1nc(OC)cc(OC)n1)C(=O)O 10.1021/jm960274q
CHEMBL304778 102704 None 0 Human Binding pKi = 8.2 8.2 354 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 424 10 1 7 3.3 CCOC(c1ccccc1)(c1ccccc1)C(Oc1nc(OC)cc(OC)n1)C(=O)O 10.1021/jm960274q
51002601 58066 None 0 Mouse Binding pKi = 8.1 8.1 123 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 906 24 2 17 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CNS(=O)(=O)c4ccc(F)cc4)nn3)c2)cc1 10.1021/jm101110w
CHEMBL1672885 58066 None 0 Mouse Binding pKi = 8.1 8.1 123 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 906 24 2 17 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CNS(=O)(=O)c4ccc(F)cc4)nn3)c2)cc1 10.1021/jm101110w
51002602 58067 None 0 Mouse Binding pKi = 8.1 8.1 812 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 751 21 1 15 4.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CF)nn3)c2)cc1 10.1021/jm101110w
CHEMBL1672886 58067 None 0 Mouse Binding pKi = 8.1 8.1 812 2
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 751 21 1 15 4.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CF)nn3)c2)cc1 10.1021/jm101110w
10549472 5335 None 0 Human Binding pKi = 7.2 7.2 - 1
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)co1 10.1021/jm000105c
CHEMBL106846 5335 None 0 Human Binding pKi = 7.2 7.2 - 1
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)co1 10.1021/jm000105c
10734431 43329 None 0 Rat Binding pKi = 6.2 6.2 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 320 3 1 4 3.1 Cc1noc(NS(=O)(=O)c2ccccc2C(F)(F)F)c1C 10.1021/jm970872k
CHEMBL150697 43329 None 0 Rat Binding pKi = 6.2 6.2 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 320 3 1 4 3.1 Cc1noc(NS(=O)(=O)c2ccccc2C(F)(F)F)c1C 10.1021/jm970872k
20747572 16475 None 0 Human Binding pKi = 6.2 6.2 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 555 10 2 7 5.3 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(Cl)c1 10.1016/s0960-894x(03)00018-0
CHEMBL12348 16475 None 0 Human Binding pKi = 6.2 6.2 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 555 10 2 7 5.3 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(Cl)c1 10.1016/s0960-894x(03)00018-0
19934546 206212 None 0 Human Binding pKi = 5.2 5.2 8 2
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 466 7 1 4 6.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(OCc3cccc4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
CHEMBL86581 206212 None 0 Human Binding pKi = 5.2 5.2 8 2
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 466 7 1 4 6.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(OCc3cccc4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
10718053 44111 None 0 Rat Binding pKi = 5.1 5.1 5 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 442 8 1 6 4.8 CCOC(=O)c1c(C)noc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 10.1021/jm970872k
CHEMBL151525 44111 None 0 Rat Binding pKi = 5.1 5.1 5 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 442 8 1 6 4.8 CCOC(=O)c1c(C)noc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 10.1021/jm970872k
10597897 41173 None 0 Rat Binding pKi = 7.1 7.1 724 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 1 5 5.0 COc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL148853 41173 None 0 Rat Binding pKi = 7.1 7.1 724 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 1 5 5.0 COc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
10668703 165181 None 0 Rat Binding pKi = 8.1 8.1 1230 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 6 2 5 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2O)c1C 10.1021/jm970872k
CHEMBL422851 165181 None 0 Rat Binding pKi = 8.1 8.1 1230 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 6 2 5 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2O)c1C 10.1021/jm970872k
44311763 204447 None 0 Human Binding pKi = 8.1 8.1 -6 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 610 14 2 7 4.4 CCCCS(=O)(=O)NC(=O)C(CC(C)C)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL72217 204447 None 0 Human Binding pKi = 8.1 8.1 -6 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 610 14 2 7 4.4 CCCCS(=O)(=O)NC(=O)C(CC(C)C)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
22574645 17791 None 0 Human Binding pKi = 8.1 8.1 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 597 14 2 8 5.1 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COCCF)c1 10.1016/s0960-894x(03)00018-0
CHEMBL12588 17791 None 0 Human Binding pKi = 8.1 8.1 - 1
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 597 14 2 8 5.1 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COCCF)c1 10.1016/s0960-894x(03)00018-0
104865 705 None 99 Human Binding pKi = 8.1 8.1 1 4
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm020289q
3494 705 None 99 Human Binding pKi = 8.1 8.1 1 4
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm020289q
392 705 None 99 Human Binding pKi = 8.1 8.1 1 4
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm020289q
CHEMBL957 705 None 99 Human Binding pKi = 8.1 8.1 1 4
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm020289q
DB00559 705 None 99 Human Binding pKi = 8.1 8.1 1 4
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm020289q
11071062 99265 None 0 Human Binding pKi = 8.1 8.1 - 1
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 494 9 1 7 5.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)CC(C)C)c1C 10.1021/jm020289q
CHEMBL281869 99265 None 0 Human Binding pKi = 8.1 8.1 - 1
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 494 9 1 7 5.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)CC(C)C)c1C 10.1021/jm020289q
44311873 204468 None 0 Human Binding pKi = 8.1 8.1 -2 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 636 13 2 7 5.0 CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C1CCCCC1 10.1016/s0960-894x(98)00387-4
CHEMBL72358 204468 None 0 Human Binding pKi = 8.1 8.1 -2 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 636 13 2 7 5.0 CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C1CCCCC1 10.1016/s0960-894x(98)00387-4
10548904 119508 None 0 Rat Binding pKi = 7.1 7.1 380 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 7 1 4 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CCC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL345551 119508 None 0 Rat Binding pKi = 7.1 7.1 380 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 7 1 4 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CCC(C)C)cc2)c1C 10.1021/jm970872k
10711546 205474 None 7 Rat Binding pKi = 5.1 5.1 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle (Endothelin A receptor) was determined by radioligand binding assayAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle (Endothelin A receptor) was determined by radioligand binding assay
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2ccccc2Br)c1C 10.1021/jm970872k
CHEMBL80506 205474 None 7 Rat Binding pKi = 5.1 5.1 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle (Endothelin A receptor) was determined by radioligand binding assayAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle (Endothelin A receptor) was determined by radioligand binding assay
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2ccccc2Br)c1C 10.1021/jm970872k
19934535 106973 None 0 Human Binding pKi = 4.1 4.1 -7 2
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 468 6 3 4 5.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3c[nH]c4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
CHEMBL315096 106973 None 0 Human Binding pKi = 4.1 4.1 -7 2
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 468 6 3 4 5.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3c[nH]c4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
104865 705 None 99 Human Binding pKi = 7.1 7.1 1 4
Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsAbility to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
3494 705 None 99 Human Binding pKi = 7.1 7.1 1 4
Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsAbility to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
392 705 None 99 Human Binding pKi = 7.1 7.1 1 4
Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsAbility to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
CHEMBL957 705 None 99 Human Binding pKi = 7.1 7.1 1 4
Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsAbility to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
DB00559 705 None 99 Human Binding pKi = 7.1 7.1 1 4
Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsAbility to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
9949368 41384 None 0 Human Binding pKi = 6.1 6.1 - 1
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 329 4 1 5 3.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccn2)c1C 10.1021/jm970872k
CHEMBL149018 41384 None 0 Human Binding pKi = 6.1 6.1 - 1
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 329 4 1 5 3.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccn2)c1C 10.1021/jm970872k
44320537 107149 None 0 Human Binding pKi = 4.1 4.1 - 1
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 479 6 2 4 5.7 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3cccc4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
CHEMBL316247 107149 None 0 Human Binding pKi = 4.1 4.1 - 1
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 479 6 2 4 5.7 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3cccc4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
44311810 104788 None 0 Human Binding pKi = 6.1 6.1 -35 2
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL310919 104788 None 0 Human Binding pKi = 6.1 6.1 -35 2
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
10814297 203527 None 0 Human Binding pKi = 7.1 7.1 17 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 472 10 1 7 4.3 COc1cc(OC)nc(OC(C(=O)O)C(Oc2ccccc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
CHEMBL66402 203527 None 0 Human Binding pKi = 7.1 7.1 17 2
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 472 10 1 7 4.3 COc1cc(OC)nc(OC(C(=O)O)C(Oc2ccccc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
44311852 103082 None 0 Human Binding pKi = 7.1 7.1 -144 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 579 10 3 4 6.0 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3cccs3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
CHEMBL307470 103082 None 0 Human Binding pKi = 7.1 7.1 -144 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 579 10 3 4 6.0 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3cccs3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
9818889 121142 None 0 Human Binding pKi = 5.1 5.1 - 1
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 330 4 1 6 2.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ncccn2)c1C 10.1021/jm970872k
CHEMBL357678 121142 None 0 Human Binding pKi = 5.1 5.1 - 1
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 330 4 1 6 2.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ncccn2)c1C 10.1021/jm970872k
10742502 121265 None 0 Rat Binding pKi = 7.1 7.1 134 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 457 9 3 6 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NCC(=O)O)c1C 10.1021/jm970872k
CHEMBL357823 121265 None 0 Rat Binding pKi = 7.1 7.1 134 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 457 9 3 6 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NCC(=O)O)c1C 10.1021/jm970872k
44311858 96601 None 0 Human Binding pKi = 8.0 8.0 -2 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 598 13 3 8 2.8 CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)O 10.1016/s0960-894x(98)00387-4
CHEMBL263301 96601 None 0 Human Binding pKi = 8.0 8.0 -2 2
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 598 13 3 8 2.8 CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)O 10.1016/s0960-894x(98)00387-4
10257882 3644 None 43 Human Binding pKi = 8.0 8.0 -11 2
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm300682j
8448 3644 None 43 Human Binding pKi = 8.0 8.0 -11 2
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm300682j
CHEMBL539423 3644 None 43 Human Binding pKi = 8.0 8.0 -11 2
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm300682j
DB12548 3644 None 43 Human Binding pKi = 8.0 8.0 -11 2
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm300682j
10257882 3644 None 43 Human Binding pKi = 8.0 8.0 -11 2
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm058225d
8448 3644 None 43 Human Binding pKi = 8.0 8.0 -11 2
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm058225d
CHEMBL539423 3644 None 43 Human Binding pKi = 8.0 8.0 -11 2
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm058225d
DB12548 3644 None 43 Human Binding pKi = 8.0 8.0 -11 2
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm058225d
9840391 104537 None 6 Rat Binding pKi = 7.1 7.1 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1C 10.1021/jm970872k
CHEMBL310427 104537 None 6 Rat Binding pKi = 7.1 7.1 - 1
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1C 10.1021/jm970872k
9840650 44368 None 0 Human Binding pKi = 6.1 6.1 - 1
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 334 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccsc2)c1C 10.1021/jm970872k
CHEMBL151819 44368 None 0 Human Binding pKi = 6.1 6.1 - 1
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 334 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccsc2)c1C 10.1021/jm970872k
9927658 121217 None 0 Human Binding pKi = 6.0 6.0 - 1
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 334 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccs2)c1C 10.1021/jm970872k
CHEMBL357789 121217 None 0 Human Binding pKi = 6.0 6.0 - 1
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 334 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccs2)c1C 10.1021/jm970872k
44314820 155719 None 0 Pig Binding pKi = 7.0 7.0 -380 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1518 45 18 17 1.0 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
77282210 155719 None 0 Pig Binding pKi = 7.0 7.0 -380 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1518 45 18 17 1.0 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
CHEMBL405377 155719 None 0 Pig Binding pKi = 7.0 7.0 -380 2
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1518 45 18 17 1.0 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
10737908 41449 None 0 Rat Binding pKi = 6.0 6.0 102 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 370 6 1 4 4.6 Cc1cnoc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 10.1021/jm970872k
CHEMBL149060 41449 None 0 Rat Binding pKi = 6.0 6.0 102 2
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 370 6 1 4 4.6 Cc1cnoc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 10.1021/jm970872k
5340 168728 None 106 Rat Binding pIC50 = 8.4 8.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 None
CHEMBL437 168728 None 106 Rat Binding pIC50 = 8.4 8.4 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 None
5329 169474 None 119 Rat Binding pIC50 = 8.3 8.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 None
CHEMBL443 169474 None 119 Rat Binding pIC50 = 8.3 8.3 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 None
5344 173471 None 101 Rat Binding pIC50 = 8.2 8.2 - 1
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C None
CHEMBL453 173471 None 101 Rat Binding pIC50 = 8.2 8.2 - 1
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C None
6662 217737 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 309 3 1 6 1.6 CC(=O)N(C1=C(C)C(C)=NO1)S(=O)(=O)C1=CC=C(N)C=C1 None
104865 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
3494 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
392 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
CHEMBL957 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
DB00559 705 None 99 Pig Binding pIC50 = 8.1 8.1 - 4
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
16004692 2452 None 91 Human Binding pIC50 = 8.0 8.0 - 0
IC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETAIC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETA
Drug Central 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br None
4809 2452 None 91 Human Binding pIC50 = 8.0 8.0 - 0
IC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETAIC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETA
Drug Central 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br None
7352 2452 None 91 Human Binding pIC50 = 8.0 8.0 - 0
IC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETAIC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETA
Drug Central 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br None
CHEMBL2103873 2452 None 91 Human Binding pIC50 = 8.0 8.0 - 0
IC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETAIC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETA
Drug Central 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br None
DB08932 2452 None 91 Human Binding pIC50 = 8.0 8.0 - 0
IC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETAIC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETA
Drug Central 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br None
10605470 3030 None 0 Human Binding pKd = 9 9.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 823 17 3 10 6.2 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)O)/Cc1cc(OCCCC(=O)NCCc2ccc(c(c2)I)O)c(c(c1)OC)OC 9489609
3519 3030 None 0 Human Binding pKd = 9 9.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 823 17 3 10 6.2 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)O)/Cc1cc(OCCCC(=O)NCCc2ccc(c(c2)I)O)c(c(c1)OC)OC 9489609
CHEMBL2068816 3030 None 0 Human Binding pKd = 9 9.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 823 17 3 10 6.2 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)O)/Cc1cc(OCCCC(=O)NCCc2ccc(c(c2)I)O)c(c(c1)OC)OC 9489609
23670447 3027 None 2 Human Binding pKd = 9.4 9.4 114 2
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
999 3027 None 2 Human Binding pKd = 9.4 9.4 114 2
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
CHEMBL1204799 3027 None 2 Human Binding pKd = 9.4 9.4 114 2
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
CHEMBL25438 3027 None 2 Human Binding pKd = 9.4 9.4 114 2
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
186002 102840 125I-ENDOTHELIN 23 Human Binding pKi = 10.5 10.5 1 3
NoneNone
PDSP KiDatabase 531 10 2 6 5.4 CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1C[C@H](C)C(=O)O)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 None
CHEMBL305576 102840 125I-ENDOTHELIN 23 Human Binding pKi = 10.5 10.5 1 3
NoneNone
PDSP KiDatabase 531 10 2 6 5.4 CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1C[C@H](C)C(=O)O)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 None
None 216074 125I-ENDOTHELIN 0 Human Binding pKi = 9.4 9.4 52 2
NoneNone
PDSP KiDatabase 520 10 2 7 4.7 CCCOC1=CC2=C(C=C1)C(C(C2C3=C(C=C(C=C3)OC)OCC(=O)O)C(=O)O)C4=CC5=C(C=C4)OCO5 None
3075702 217330 125I-Endothelin 1 0 Human Binding pKi = 6 6.0 -2 37
NoneNone
PDSP KiDatabase 198 3 1 3 1.5 C1CNC1COC2=CN=C(C=C2)Cl None
44208932 140705 UNDEFINED 7 Human Binding pKi = 5 5.0 -89125 37
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
CHEMBL381689 140705 UNDEFINED 7 Human Binding pKi = 5 5.0 -89125 37
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
1973 203481 125I-ENDOTHELIN 15 Rat Binding pKi = 5 5.0 -3 37
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 203481 125I-ENDOTHELIN 15 Rat Binding pKi = 5 5.0 -3 37
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 203481 125I-ENDOTHELIN 15 Rat Binding pKi = 5 5.0 -3 37
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
None 216491 125I-ENDOTHELIN 0 Rat Binding pKi = 5 5.0 -10471285 17
NoneNone
PDSP KiDatabase 372 2 1 3 4.4 CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl None
104865 705 125I-ENDOTHELIN 99 Human Binding pKi = 7.8 7.8 1 4
NoneNone
PDSP KiDatabase 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
3494 705 125I-ENDOTHELIN 99 Human Binding pKi = 7.8 7.8 1 4
NoneNone
PDSP KiDatabase 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
392 705 125I-ENDOTHELIN 99 Human Binding pKi = 7.8 7.8 1 4
NoneNone
PDSP KiDatabase 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
CHEMBL957 705 125I-ENDOTHELIN 99 Human Binding pKi = 7.8 7.8 1 4
NoneNone
PDSP KiDatabase 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
DB00559 705 125I-ENDOTHELIN 99 Human Binding pKi = 7.8 7.8 1 4
NoneNone
PDSP KiDatabase 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
176 398 None 66 Human Binding pKi = 8.3 8.3 -7 31
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
2157 398 None 66 Human Binding pKi = 8.3 8.3 -7 31
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
2566 398 None 66 Human Binding pKi = 8.3 8.3 -7 31
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
CHEMBL633 398 None 66 Human Binding pKi = 8.3 8.3 -7 31
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
DB01118 398 None 66 Human Binding pKi = 8.3 8.3 -7 31
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
1481 2064 None 116 Human Binding pKi = 8.3 8.3 -112 3
Binding affinity to ETA receptorBinding affinity to ETA receptor
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
3749 2064 None 116 Human Binding pKi = 8.3 8.3 -112 3
Binding affinity to ETA receptorBinding affinity to ETA receptor
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
589 2064 None 116 Human Binding pKi = 8.3 8.3 -112 3
Binding affinity to ETA receptorBinding affinity to ETA receptor
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
6908 2064 None 116 Human Binding pKi = 8.3 8.3 -112 3
Binding affinity to ETA receptorBinding affinity to ETA receptor
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
CHEMBL1513 2064 None 116 Human Binding pKi = 8.3 8.3 -112 3
Binding affinity to ETA receptorBinding affinity to ETA receptor
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
DB01029 2064 None 116 Human Binding pKi = 8.3 8.3 -112 3
Binding affinity to ETA receptorBinding affinity to ETA receptor
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
5472495 186631 None 47 Human Binding pKi = 8.3 8.3 - 1
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 None
CHEMBL488025 186631 None 47 Human Binding pKi = 8.3 8.3 - 1
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 None
104865 705 None 99 Human Binding pKi = 8.1 8.1 1 4
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
3494 705 None 99 Human Binding pKi = 8.1 8.1 1 4
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
392 705 None 99 Human Binding pKi = 8.1 8.1 1 4
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
CHEMBL957 705 None 99 Human Binding pKi = 8.1 8.1 1 4
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
DB00559 705 None 99 Human Binding pKi = 8.1 8.1 1 4
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
104865 705 None 99 Rat Binding pKi = 8.1 8.1 -1 4
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
3494 705 None 99 Rat Binding pKi = 8.1 8.1 -1 4
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
392 705 None 99 Rat Binding pKi = 8.1 8.1 -1 4
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
CHEMBL957 705 None 99 Rat Binding pKi = 8.1 8.1 -1 4
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
DB00559 705 None 99 Rat Binding pKi = 8.1 8.1 -1 4
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
104865 705 125I-ENDOTHELIN 99 Human Binding pKi = 8.1 8.1 1 4
NoneNone
PDSP KiDatabase 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
3494 705 125I-ENDOTHELIN 99 Human Binding pKi = 8.1 8.1 1 4
NoneNone
PDSP KiDatabase 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
392 705 125I-ENDOTHELIN 99 Human Binding pKi = 8.1 8.1 1 4
NoneNone
PDSP KiDatabase 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
CHEMBL957 705 125I-ENDOTHELIN 99 Human Binding pKi = 8.1 8.1 1 4
NoneNone
PDSP KiDatabase 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
DB00559 705 125I-ENDOTHELIN 99 Human Binding pKi = 8.1 8.1 1 4
NoneNone
PDSP KiDatabase 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
11477084 3608 None 53 Human Binding pKi = 8.0 8.0 1 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
216235 3608 None 53 Human Binding pKi = 8.0 8.0 1 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
3548 3608 None 53 Human Binding pKi = 8.0 8.0 1 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
3950 3608 None 53 Human Binding pKi = 8.0 8.0 1 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
CHEMBL282724 3608 None 53 Human Binding pKi = 8.0 8.0 1 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
DB06268 3608 None 53 Human Binding pKi = 8.0 8.0 1 2
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
11477084 3608 None 53 Rat Binding pKi = 8.0 8.0 -1 2
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
216235 3608 None 53 Rat Binding pKi = 8.0 8.0 -1 2
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
3548 3608 None 53 Rat Binding pKi = 8.0 8.0 -1 2
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
3950 3608 None 53 Rat Binding pKi = 8.0 8.0 -1 2
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
CHEMBL282724 3608 None 53 Rat Binding pKi = 8.0 8.0 -1 2
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
DB06268 3608 None 53 Rat Binding pKi = 8.0 8.0 -1 2
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
3951 391 None 86 Human Binding pKi = 8.0 8.0 -1 2
NoneNone
Drug Central 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 None
4337 391 None 86 Human Binding pKi = 8.0 8.0 -1 2
NoneNone
Drug Central 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 None
6918493 391 None 86 Human Binding pKi = 8.0 8.0 -1 2
NoneNone
Drug Central 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 None
CHEMBL1111 391 None 86 Human Binding pKi = 8.0 8.0 -1 2
NoneNone
Drug Central 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 None
DB06403 391 None 86 Human Binding pKi = 8.0 8.0 -1 2
NoneNone
Drug Central 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 None
12286 947 None 36 Human Binding pKi = 9.9 9.9 1348 2
Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9703472
6433095 947 None 36 Human Binding pKi = 9.9 9.9 1348 2
Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9703472
CHEMBL109648 947 None 36 Human Binding pKi = 9.9 9.9 1348 2
Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9703472
DB06677 947 None 36 Human Binding pKi = 9.9 9.9 1348 2
Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9703472
159594 522 None 45 Human Binding pKi = 10.5 10.5 1 3
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
159594 522 None 45 Human Binding pKi = 10.5 10.5 1 3
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8676339
3487 522 None 45 Human Binding pKi = 10.5 10.5 1 3
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
3487 522 None 45 Human Binding pKi = 10.5 10.5 1 3
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8676339
CHEMBL9194 522 None 45 Human Binding pKi = 10.5 10.5 1 3
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
CHEMBL9194 522 None 45 Human Binding pKi = 10.5 10.5 1 3
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8676339
DB06199 522 None 45 Human Binding pKi = 10.5 10.5 1 3
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
DB06199 522 None 45 Human Binding pKi = 10.5 10.5 1 3
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8676339
13015 1529 None 30 Human Binding pKi = 11 11.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 536 8 1 7 5.8 CC1=C(ON=C1NS(=O)(=O)C2=CC=CC=C2C3=C(C=C(C=C3)C4=NC=CO4)CN(C)C(=O)CC(C)(C)C)C 12502366
156690 1529 None 30 Human Binding pKi = 11 11.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 536 8 1 7 5.8 CC1=C(ON=C1NS(=O)(=O)C2=CC=CC=C2C3=C(C=C(C=C3)C4=NC=CO4)CN(C)C(=O)CC(C)(C)C)C 12502366
CHEMBL383581 1529 None 30 Human Binding pKi = 11 11.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 536 8 1 7 5.8 CC1=C(ON=C1NS(=O)(=O)C2=CC=CC=C2C3=C(C=C(C=C3)C4=NC=CO4)CN(C)C(=O)CC(C)(C)C)C 12502366
10257882 3644 None 43 Human Binding pKi = 8.0 8.0 -11 2
UnclassifiedUnclassified
Guide to Pharmacology 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 16220969
8448 3644 None 43 Human Binding pKi = 8.0 8.0 -11 2
UnclassifiedUnclassified
Guide to Pharmacology 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 16220969
CHEMBL539423 3644 None 43 Human Binding pKi = 8.0 8.0 -11 2
UnclassifiedUnclassified
Guide to Pharmacology 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 16220969
DB12548 3644 None 43 Human Binding pKi = 8.0 8.0 -11 2
UnclassifiedUnclassified
Guide to Pharmacology 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 16220969
13016 669 None 13 Human Binding pKi = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10956219
9843631 669 None 13 Human Binding pKi = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10956219
CHEMBL24461 669 None 13 Human Binding pKi = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10956219
177236 1324 None 45 Human Binding pKi = 8.9 8.9 2 3
UnclassifiedUnclassified
Guide to Pharmacology 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 8667356
3508 1324 None 45 Human Binding pKi = 8.9 8.9 2 3
UnclassifiedUnclassified
Guide to Pharmacology 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 8667356
CHEMBL23261 1324 None 45 Human Binding pKi = 8.9 8.9 2 3
UnclassifiedUnclassified
Guide to Pharmacology 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 8667356
DB04883 1324 None 45 Human Binding pKi = 8.9 8.9 2 3
UnclassifiedUnclassified
Guide to Pharmacology 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 8667356