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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

(+)-ADTN	297	None	18	Human	Binding	pKi	None	-	6.00	-588	7	Unclassified	Guide to Pharmacology	179.1	0	3	3	0.91	NC1CCc2cc(O)c(O)cc2C1	https://pubmed.ncbi.nlm.nih.gov/1826762
(+)-butaclamol	746	3H-SCH23390	9	Human	Binding	pKi	=	27.00	7.57	-61	25	-	PDSP KiDatabase	361.2	0	1	2	4.84	CC(C)(C)[C@]1(O)CCN2C[C@H]3c4ccccc4CCc4cccc(c43)[C@@H]2C1	-
(+)-butaclamol	746	None	9	Human	Binding	pKi	None	-	7.60	-61	25	Unclassified	Guide to Pharmacology	361.2	0	1	2	4.84	CC(C)(C)[C@]1(O)CCN2C[C@H]3c4ccccc4CCc4cccc(c43)[C@@H]2C1	https://pubmed.ncbi.nlm.nih.gov/1826762
(-)-stepholidine	3691	None	40	Human	Binding	Ki	=	4.40	8.36	1	35	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting	ChEMBL	327.1	2	2	5	2.77	COc1cc2c(cc1O)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	https://dx.doi.org/10.1016/j.bmc.2009.08.028
(-)-stepholidine	3691	3H-SCH23390	40	Human	Binding	pKi	=	4.40	8.36	1	35	-	PDSP KiDatabase	327.1	2	2	5	2.77	COc1cc2c(cc1O)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	-
(1R,2S)-PHENYLPROPANOLAMINE	27120	3H-SCH23390	13	Human	Binding	pKi	=	10000.00	5.00	-38	42	-	PDSP KiDatabase	151.1	2	2	2	1.07	C[C@H](N)[C@H](O)c1ccccc1	-
(R)-SKF-38393	91633	None	9	Human	Binding	Ki	=	245.47	6.61	3	6	Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)	ChEMBL	255.1	1	3	3	2.38	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	https://dx.doi.org/10.1016/j.bmcl.2013.12.024
(R)-SKF-38393	91633	None	9	Human	Binding	Ki	=	0.50	9.30	3	6	Agonist activity at dopamine D5 receptor (unknown origin)	ChEMBL	255.1	1	3	3	2.38	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	https://dx.doi.org/10.1016/j.bmcl.2020.127305
(R)-SKF-38393	91633	None	9	Human	Binding	Ki	=	247.00	6.61	3	6	Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)	ChEMBL	255.1	1	3	3	2.38	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	https://dx.doi.org/10.1016/j.bmcl.2013.12.024
2-(4'-Methylaminophenyl)Benzothiazole	220178	3H-SCH23390	0	Human	Binding	pKi	=	13.00	7.89	-6	7	-	PDSP KiDatabase	268.1	3	1	5	4.75	CNc1ccc(N=Nc2ccc3ncsc3c2)cc1	-
5-hydroxytryptamine	139	None	45	Human	Binding	pKi	None	-	5.50	-7244	61	Unclassified	Guide to Pharmacology	176.1	2	3	2	1.38	NCCc1c[nH]c2ccc(O)cc12	https://pubmed.ncbi.nlm.nih.gov/1826762
5-hydroxytryptamine	139	3H-SCH23390	45	Human	Binding	pKi	=	3000.00	5.52	-7244	61	-	PDSP KiDatabase	176.1	2	3	2	1.38	NCCc1c[nH]c2ccc(O)cc12	-
A77636	208	None	8	Human	Binding	Ki	=	3.02	8.52	1	27	PDSP Secondary Binding target: DRD5 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.	ChEMBL	329.2	2	3	4	3.25	NC[C@@H]1O[C@H](C23CC4CC(CC(C4)C2)C3)Cc2c1ccc(O)c2O	https://dx.doi.org/10.6019/CHEMBL5442175
ABT-594	219818	3H-SCH23390	0	Human	Binding	pKi	=	1000.00	6.00	-2	37	-	PDSP KiDatabase	198.1	3	1	3	1.48	Clc1ccc(OCC2CCN2)cn1	-
ADTN, (+)	218719	3H-SCH23390	0	Human	Binding	pKi	=	909.00	6.04	-2	4	-	PDSP KiDatabase	226.2	0	2	2	1.35	O=C1CCCCCNC(=O)CCCCCN1	-
AMENTOFLAVONE	205483	3H-SCH23390	63	Human	Binding	pKi	=	10000.00	5.00	-275	33	-	PDSP KiDatabase	538.1	3	6	10	5.13	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	-
amisulpride	400	3H-SCH23390	72	Human	Binding	pKi	=	10000.00	5.00	-4365	53	-	PDSP KiDatabase	369.2	7	2	6	1.28	CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)c(N)cc1OC	-
amitriptyline	401	UNDEFINED	38	Human	Binding	pKi	=	170.00	6.77	-112	51	-	PDSP KiDatabase	277.2	3	0	1	4.17	CN(C)CCC=C1c2ccccc2CCc2ccccc21	-
amitriptyline	401	None	38	Human	Binding	pKi	=	6.77	8.17	-112	51	None	Drug Central	277.2	3	0	1	4.17	CN(C)CCC=C1c2ccccc2CCc2ccccc21	-
amitriptyline	401	None	38	Human	Binding	Ki	=	170.00	6.77	-112	51	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	277.2	3	0	1	4.17	CN(C)CCC=C1c2ccccc2CCc2ccccc21	https://dx.doi.org/10.1016/j.bmcl.2008.09.012

Showing 1 to 20 of 717 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

A68930	205	None	17	Human	Functional	pEC50	=	-	6.60	-128	5	Unclassified	Guide to Pharmacology	271.1	2	3	4	2.41	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(O)c2O	https://pubmed.ncbi.nlm.nih.gov/16318870
CHEMBL201093	73112	None	0	Human	Functional	Ki	=	33.70	7.47	-	5	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	257.1	0	0	2	3.37	CN1CCc2ccccc2Cc2ccsc2CC1	https://dx.doi.org/10.1021/jm050846j
CHEMBL201170	73177	None	0	Human	Functional	Ki	=	1.69	8.77	-	6	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	267.2	0	1	2	3.01	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	https://dx.doi.org/10.1021/jm050846j
CHEMBL201170	73177	None	0	Human	Functional	Ki	=	1.69	8.77	-	6	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267.2	0	1	2	3.01	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	https://dx.doi.org/10.1021/jm051237e
CHEMBL201483	73411	None	0	Human	Functional	Ki	=	337.00	6.47	-	4	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	254.2	0	0	2	2.65	CN1CCc2ccccc2Cc2ccn(C)c2CC1	https://dx.doi.org/10.1021/jm050846j
CHEMBL201525	73420	None	0	Human	Functional	Ki	=	3.09	8.51	-	6	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	251.2	0	0	1	3.31	CN1CCc2ccccc2Cc2ccccc2CC1	https://dx.doi.org/10.1021/jm050846j
CHEMBL201584	73433	None	5	Human	Functional	Ki	=	112.00	6.95	-	3	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304.2	1	1	1	4.37	CN1CCc2c([nH]c3ccccc23)CC(c2ccccc2)CC1	https://dx.doi.org/10.1021/jm050846j
CHEMBL203029	74720	None	0	Human	Functional	Ki	=	2.32	8.63	-	4	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	283.2	0	2	3	2.72	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	https://dx.doi.org/10.1021/jm050846j
CHEMBL203047	74725	None	0	Human	Functional	Ki	=	3.10	8.51	-	4	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301.1	0	1	2	3.67	CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1	https://dx.doi.org/10.1021/jm051237e
CHEMBL203637	75199	None	0	Human	Functional	Ki	=	0.05	10.28	-	6	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301.1	0	1	2	3.67	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	https://dx.doi.org/10.1021/jm051237e
CHEMBL203689	75278	None	0	Human	Functional	Ki	=	10.40	7.98	-	4	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267.2	0	1	2	3.01	CN1CCc2ccccc2Cc2c(O)cccc2CC1	https://dx.doi.org/10.1021/jm051237e
CHEMBL203734	75317	None	0	Human	Functional	Ki	=	59.00	7.23	-	4	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	349.1	1	0	2	4.62	COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2	https://dx.doi.org/10.1021/jm051237e
CHEMBL204065	75443	None	0	Human	Functional	Ki	=	11.50	7.94	-	4	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	311.2	2	0	3	3.33	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	https://dx.doi.org/10.1021/jm051237e
CHEMBL204098	75449	None	0	Human	Functional	Ki	=	39.50	7.40	-	3	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	282.2	0	2	3	2.60	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	https://dx.doi.org/10.1021/jm051237e
CHEMBL216258	81612	None	0	Human	Functional	Ki	=	2.80	8.55	-	5	Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304.2	0	1	1	4.18	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	https://dx.doi.org/10.1021/jm060213k
CHEMBL216439	81864	None	0	Human	Functional	Ki	=	71.60	7.14	-	6	Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304.2	0	1	1	4.18	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	https://dx.doi.org/10.1021/jm060213k
CHEMBL3697578	132505	None	15	Human	Functional	EC50	=	12.00	7.92	-2	2	Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	389.1	5	1	6	3.15	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	https://dx.doi.org/10.1021/acsmedchemlett.9b00050
CHEMBL379662	139642	None	0	Human	Functional	Ki	=	54.60	7.26	-	4	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281.2	1	0	2	3.32	COc1cccc2c1Cc1ccccc1CCN(C)CC2	https://dx.doi.org/10.1021/jm051237e
CHEMBL380330	140252	None	0	Human	Functional	Ki	=	7.20	8.14	-	6	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281.2	1	0	2	3.32	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	https://dx.doi.org/10.1021/jm051237e
CHEMBL380464	140275	None	0	Human	Functional	Ki	=	1.60	8.80	-	4	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301.1	0	1	2	3.67	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	https://dx.doi.org/10.1021/jm051237e

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Ligand source activities (1 row/activity)