GPCRdb

(-)-stepholidine

Agent/drug
Bioactivity

(-)-stepholidine

SMILES	COc1cc2c(cc1O)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2
InChIKey	JKPISQIIWUONPB-HNNXBMFYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	2
Rotatable bonds	2
Molecular weight (Da)	327.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	5.65	5.65	5.65	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.16	5.16	5.16	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.67	6.67	6.67	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
δ	OPRD	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
κ	OPRK	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
μ	OPRM	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.84	6.84	6.84	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.16	5.16	5.16	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.65	6.65	6.65	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 20 of 40 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₁	DRD1	Rat	Dopamine	A	pEC50	4.39	4.39	4.39	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	7.91	7.91	7.91	ChEMBL
D₁	DRD1	Human	Dopamine	A	pEC50	7.64	7.64	7.64	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	5.36	6.17	6.98	ChEMBL

Showing 1 to 4 of 4 entries

(-)-stepholidine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV 0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.