GPCRdb

(R)-SKF-38393

Agent/drug
Bioactivity

(R)-SKF-38393

SMILES	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2
InChIKey	JUDKOGFHZYMDMF-CQSZACIVSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	3
Rotatable bonds	1
Molecular weight (Da)	255.1

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	D₁ D₂ D₅

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₁	DRD1	Rat	Dopamine	A	pKi	7.19	7.28	7.46	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	6.50	7.52	9.00	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKd	6.82	6.82	6.82	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKi	5.16	5.29	5.54	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	5.02	5.18	5.33	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKd	5.02	5.02	5.02	ChEMBL
D₅	DRD5	Human	Dopamine	A	pKi	6.61	7.51	9.30	ChEMBL

Showing 1 to 7 of 7 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₁	DRD1	Goldfish	Dopamine	A	pEC50	6.02	6.02	6.02	ChEMBL
D₁	DRD1	Rat	Dopamine	A	pEC50	7.00	7.00	7.00	ChEMBL
D₁	DRD1	Rat	Dopamine	A	pIC50	7.30	7.38	7.46	ChEMBL
D₁	DRD1	Human	Dopamine	A	pEC50	6.41	7.10	7.52	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	5.43	5.43	5.43	ChEMBL

Showing 1 to 5 of 5 entries

(R)-SKF-38393

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV 0

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	D₁ D₂ D₅

Compound is not listed as a drug.