GPCRdb

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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

	CHEMBL3889627	142475	None	1	Human	Binding	IC50	=	10.00	8.00	-	2	Antagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP binding	ChEMBL	453.2	7	2	5	2.84	CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.09.047
	CHEMBL3889627	142475	None	1	Human	Binding	IC50	=	1.00	9.00	-	2	Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis	ChEMBL	453.2	7	2	5	2.84	CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.09.047
	CHEMBL3908230	144746	None	2	Human	Binding	IC50	=	50.12	7.30	-	1	Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis	ChEMBL	518.1	8	2	8	2.68	CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.09.047
	CHEMBL3908230	144746	None	2	Human	Binding	IC50	=	53.00	7.28	-	1	Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis	ChEMBL	518.1	8	2	8	2.68	CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.09.047
	CHEMBL3923733	146755	None	0	Human	Binding	IC50	=	15.85	7.80	-	2	Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis	ChEMBL	453.2	7	2	5	2.84	CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3cc[nH]c3c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.09.047
	CHEMBL3926111	147048	None	0	Human	Binding	IC50	=	501.19	6.30	-	2	Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis	ChEMBL	483.1	7	2	4	4.11	CC1CCN(C(=O)[C@@H](CCc2ccccc2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.09.047
	CHEMBL3933303	147963	None	0	Human	Binding	IC50	=	79.43	7.10	-	1	Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis	ChEMBL	457.2	7	2	6	2.56	Cc1ccc(S(=O)(=O)NC(CCn2cccc2C#N)C(=O)N2CCC(C)CC2)c(C)c1N	https://dx.doi.org/10.1016/j.bmcl.2016.09.047
	CHEMBL3943972	149293	None	0	Human	Binding	IC50	=	1258.93	5.90	-	1	Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis	ChEMBL	474.1	7	2	7	2.16	CC1CCN(C(=O)C(CCn2nccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.09.047
	CHEMBL3948828	149917	None	0	Human	Binding	IC50	=	1258.93	5.90	-	1	Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis	ChEMBL	473.1	7	2	6	2.77	CC1CCN(C(=O)C(CCn2cccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.09.047
	CHEMBL3951018	150192	None	0	Human	Binding	IC50	=	15.85	7.80	-	2	Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis	ChEMBL	497.1	7	2	6	3.24	CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.09.047
	CHEMBL3951018	150192	None	0	Human	Binding	IC50	=	3.16	8.50	-	2	Displacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysis	ChEMBL	497.1	7	2	6	3.24	CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.09.047
	CHEMBL3951018	150192	None	0	Human	Binding	IC50	=	19.95	7.70	-	2	Antagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP binding	ChEMBL	497.1	7	2	6	3.24	CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.09.047
	CHEMBL3951018	150192	None	0	Human	Binding	IC50	=	3.40	8.47	-	2	Reversible inhibition of human CCL27-Fc binding to CCR10 expressed in HEK cell membranes by immunochemical binding assay	ChEMBL	497.1	7	2	6	3.24	CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.09.047
	CHEMBL3951018	150192	None	0	Human	Binding	IC50	=	3.40	8.47	-	2	Displacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysis	ChEMBL	497.1	7	2	6	3.24	CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.09.047
	CHEMBL3964547	151822	None	0	Human	Binding	IC50	=	251.19	6.60	-	1	Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis	ChEMBL	507.1	7	2	6	3.42	CC1CCN(C(=O)C(CCn2ccnc2Cl)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.09.047
	CHEMBL3971886	152678	None	0	Human	Binding	IC50	=	12.59	7.90	-	1	Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis	ChEMBL	453.2	7	2	5	2.84	CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3[nH]ccc3c2)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.09.047

Showing 1 to 16 of 16 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI