Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type

 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
44252324 142388 None 1 Human Functional pIC50 = 9.4 9.4 42 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3889627 142388 None 1 Human Functional pIC50 = 9.4 9.4 42 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
44252324 142388 None 1 Human Functional pIC50 = 9 9.0 42 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3889627 142388 None 1 Human Functional pIC50 = 9 9.0 42 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
44252324 142388 None 1 Human Functional pIC50 = 9 9.0 42 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3889627 142388 None 1 Human Functional pIC50 = 9 9.0 42 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
44252324 142388 None 1 Human Functional pIC50 = 8.9 8.9 42 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3889627 142388 None 1 Human Functional pIC50 = 8.9 8.9 42 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
58509213 150104 None 0 Human Functional pIC50 = 8.7 8.7 151 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3951018 150104 None 0 Human Functional pIC50 = 8.7 8.7 151 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
44252324 142388 None 1 Human Functional pIC50 = 8.7 8.7 42 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3889627 142388 None 1 Human Functional pIC50 = 8.7 8.7 42 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
58509355 142643 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 507 7 2 5 3.4 N#Cc1cccn1CCC(NS(=O)(=O)c1cccc2[nH]ccc12)C(=O)N1CCC(C(F)(F)F)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3891692 142643 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 507 7 2 5 3.4 N#Cc1cccn1CCC(NS(=O)(=O)c1cccc2[nH]ccc12)C(=O)N1CCC(C(F)(F)F)CC1 10.1016/j.bmcl.2016.09.047
58509356 152575 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 439 7 2 5 2.6 N#Cc1cccn1CCC(NS(=O)(=O)c1cccc2[nH]ccc12)C(=O)N1CCCCC1 10.1016/j.bmcl.2016.09.047
CHEMBL3971826 152575 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 439 7 2 5 2.6 N#Cc1cccn1CCC(NS(=O)(=O)c1cccc2[nH]ccc12)C(=O)N1CCCCC1 10.1016/j.bmcl.2016.09.047
58509165 147875 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 457 7 2 6 2.6 Cc1ccc(S(=O)(=O)NC(CCn2cccc2C#N)C(=O)N2CCC(C)CC2)c(C)c1N 10.1016/j.bmcl.2016.09.047
CHEMBL3933303 147875 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 457 7 2 6 2.6 Cc1ccc(S(=O)(=O)NC(CCn2cccc2C#N)C(=O)N2CCC(C)CC2)c(C)c1N 10.1016/j.bmcl.2016.09.047
44252464 146667 None 0 Mouse Functional pIC50 = 6 6.0 -89 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3923733 146667 None 0 Mouse Functional pIC50 = 6 6.0 -89 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1016/j.bmcl.2016.09.047
58504873 146960 None 0 Mouse Functional pIC50 = 5 5.0 -17 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 483 7 2 4 4.1 CC1CCN(C(=O)[C@@H](CCc2ccccc2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3926111 146960 None 0 Mouse Functional pIC50 = 5 5.0 -17 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 483 7 2 4 4.1 CC1CCN(C(=O)[C@@H](CCc2ccccc2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509213 150104 None 0 Human Functional pIC50 = 7.9 7.9 151 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3951018 150104 None 0 Human Functional pIC50 = 7.9 7.9 151 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509213 150104 None 0 Human Functional pIC50 = 7.9 7.9 151 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3951018 150104 None 0 Human Functional pIC50 = 7.9 7.9 151 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58504900 142590 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 517 7 2 4 4.8 CC1CCN(C(=O)C(CCc2ccccc2Cl)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3891289 142590 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 517 7 2 4 4.8 CC1CCN(C(=O)C(CCc2ccccc2Cl)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58508974 149416 None 0 Human Functional pIC50 = 6.9 6.9 50 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 467 7 1 6 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3c2ccn3C)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3945769 149416 None 0 Human Functional pIC50 = 6.9 6.9 50 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 467 7 1 6 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3c2ccn3C)CC1 10.1016/j.bmcl.2016.09.047
58509106 151304 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 455 7 3 6 1.6 N#Cc1cccn1CCC(NS(=O)(=O)c1cccc2[nH]ccc12)C(=O)N1CCC(O)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3960700 151304 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 455 7 3 6 1.6 N#Cc1cccn1CCC(NS(=O)(=O)c1cccc2[nH]ccc12)C(=O)N1CCC(O)CC1 10.1016/j.bmcl.2016.09.047
58509273 143269 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 414 7 1 5 2.4 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccccc2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3896799 143269 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 414 7 1 5 2.4 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccccc2)CC1 10.1016/j.bmcl.2016.09.047
58509102 152282 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 483 7 2 6 3.0 N#Cc1cccn1CCC(NS(=O)(=O)c1cc(Cl)c(N)c(Cl)c1)C(=O)N1CCCCC1 10.1016/j.bmcl.2016.09.047
CHEMBL3969321 152282 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 483 7 2 6 3.0 N#Cc1cccn1CCC(NS(=O)(=O)c1cc(Cl)c(N)c(Cl)c1)C(=O)N1CCCCC1 10.1016/j.bmcl.2016.09.047
58509213 150104 None 0 Human Functional pIC50 = 6.8 6.8 151 2
Antagonist activity at human CCR10 expressed in HEK cells assessed as inhibition of human CCL27-dependent cAMP productionAntagonist activity at human CCR10 expressed in HEK cells assessed as inhibition of human CCL27-dependent cAMP production
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3951018 150104 None 0 Human Functional pIC50 = 6.8 6.8 151 2
Antagonist activity at human CCR10 expressed in HEK cells assessed as inhibition of human CCL27-dependent cAMP productionAntagonist activity at human CCR10 expressed in HEK cells assessed as inhibition of human CCL27-dependent cAMP production
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509238 149829 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 473 7 2 6 2.8 CC1CCN(C(=O)C(CCn2cccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3948828 149829 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 473 7 2 6 2.8 CC1CCN(C(=O)C(CCn2cccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509213 150104 None 0 Mouse Functional pIC50 = 5.8 5.8 -151 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3951018 150104 None 0 Mouse Functional pIC50 = 5.8 5.8 -151 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
134155728 151031 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)[C@H](CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3958582 151031 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)[C@H](CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
44252324 142388 None 1 Mouse Functional pIC50 = 4.8 4.8 -42 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3889627 142388 None 1 Mouse Functional pIC50 = 4.8 4.8 -42 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
58509160 146022 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 3.0 CC1CCCCN1C(=O)C(CCn1cccc1C#N)NS(=O)(=O)c1cccc2[nH]ccc12 10.1016/j.bmcl.2016.09.047
CHEMBL3918664 146022 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 3.0 CC1CCCCN1C(=O)C(CCn1cccc1C#N)NS(=O)(=O)c1cccc2[nH]ccc12 10.1016/j.bmcl.2016.09.047
58509213 150104 None 0 Human Functional pIC50 = 7.7 7.7 151 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3951018 150104 None 0 Human Functional pIC50 = 7.7 7.7 151 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
44252468 152589 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3[nH]ccc3c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3971886 152589 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3[nH]ccc3c2)CC1 10.1016/j.bmcl.2016.09.047
58509377 144850 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 3.0 N#Cc1cccn1CCC(NS(=O)(=O)c1cccc2[nH]ccc12)C(=O)N1CCCCCC1 10.1016/j.bmcl.2016.09.047
CHEMBL3909737 144850 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 3.0 N#Cc1cccn1CCC(NS(=O)(=O)c1cccc2[nH]ccc12)C(=O)N1CCCCCC1 10.1016/j.bmcl.2016.09.047
44252324 142388 None 1 Human Functional pIC50 = 7.6 7.6 42 2
Antagonist activity at human CCR10 expressed in HEK cells assessed as inhibition of human CCL27-dependent cAMP productionAntagonist activity at human CCR10 expressed in HEK cells assessed as inhibition of human CCL27-dependent cAMP production
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3889627 142388 None 1 Human Functional pIC50 = 7.6 7.6 42 2
Antagonist activity at human CCR10 expressed in HEK cells assessed as inhibition of human CCL27-dependent cAMP productionAntagonist activity at human CCR10 expressed in HEK cells assessed as inhibition of human CCL27-dependent cAMP production
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
44252324 142388 None 1 Mouse Functional pIC50 = 7.6 7.6 -42 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3889627 142388 None 1 Mouse Functional pIC50 = 7.6 7.6 -42 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
58509350 144658 None 2 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assay
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3908230 144658 None 2 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assay
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509048 143782 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.4 N#Cc1cccn1CCC(NS(=O)(=O)c1cc(Cl)c(N)c(Cl)c1)C(=O)N1CCCCCC1 10.1016/j.bmcl.2016.09.047
CHEMBL3901006 143782 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.4 N#Cc1cccn1CCC(NS(=O)(=O)c1cc(Cl)c(N)c(Cl)c1)C(=O)N1CCCCCC1 10.1016/j.bmcl.2016.09.047
66883409 148989 None 0 Human Functional pIC50 = 6.6 6.6 31 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3cc[nH]c23)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3942284 148989 None 0 Human Functional pIC50 = 6.6 6.6 31 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3cc[nH]c23)CC1 10.1016/j.bmcl.2016.09.047
58509301 153530 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 507 7 2 6 3.4 CC1CCN(C(=O)C(CCn2nccc2Cl)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3979967 153530 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 507 7 2 6 3.4 CC1CCN(C(=O)C(CCn2nccc2Cl)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
145957924 162093 None 0 Human Functional pIC50 = 5.6 5.6 1 4
Antagonist activity at human CCR10 expressed in human U2OS cells assessed as inhibition of CCL27-induced beta-arrestin recruitment pre-incubated for 30 mins before CCL27 stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human CCR10 expressed in human U2OS cells assessed as inhibition of CCL27-induced beta-arrestin recruitment pre-incubated for 30 mins before CCL27 stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C\c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL4161021 162093 None 0 Human Functional pIC50 = 5.6 5.6 1 4
Antagonist activity at human CCR10 expressed in human U2OS cells assessed as inhibition of CCL27-induced beta-arrestin recruitment pre-incubated for 30 mins before CCL27 stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human CCR10 expressed in human U2OS cells assessed as inhibition of CCL27-induced beta-arrestin recruitment pre-incubated for 30 mins before CCL27 stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C\c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
145952624 162385 None 0 Human Functional pIC50 = 5.5 5.5 1 4
Antagonist activity at human CCR10 expressed in human U2OS cells assessed as inhibition of CCL27-induced beta-arrestin recruitment pre-incubated for 30 mins before CCL27 stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human CCR10 expressed in human U2OS cells assessed as inhibition of CCL27-induced beta-arrestin recruitment pre-incubated for 30 mins before CCL27 stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 889 21 2 10 3.3 CC[C@H](C)[C@@H](OC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL4165525 162385 None 0 Human Functional pIC50 = 5.5 5.5 1 4
Antagonist activity at human CCR10 expressed in human U2OS cells assessed as inhibition of CCL27-induced beta-arrestin recruitment pre-incubated for 30 mins before CCL27 stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human CCR10 expressed in human U2OS cells assessed as inhibition of CCL27-induced beta-arrestin recruitment pre-incubated for 30 mins before CCL27 stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 889 21 2 10 3.3 CC[C@H](C)[C@@H](OC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
44252324 142388 None 1 Human Functional pIC50 = 5.5 5.5 42 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3889627 142388 None 1 Human Functional pIC50 = 5.5 5.5 42 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
58509125 149205 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 474 7 2 7 2.2 CC1CCN(C(=O)C(CCn2nccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3943972 149205 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 474 7 2 7 2.2 CC1CCN(C(=O)C(CCn2nccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509038 146101 None 0 Mouse Functional pIC50 = 5.5 5.5 -50 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 498 7 2 7 2.6 CC1CCN(C(=O)C(CCn2nccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3919363 146101 None 0 Mouse Functional pIC50 = 5.5 5.5 -50 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 498 7 2 7 2.6 CC1CCN(C(=O)C(CCn2nccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509203 151180 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2c(N)cc(Cl)cc2Cl)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3959737 151180 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2c(N)cc(Cl)cc2Cl)CC1 10.1016/j.bmcl.2016.09.047
58509058 149564 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 551 7 2 6 3.8 N#Cc1cccn1CCC(NS(=O)(=O)c1cc(Cl)c(N)c(Cl)c1)C(=O)N1CCC(C(F)(F)F)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3946799 149564 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 551 7 2 6 3.8 N#Cc1cccn1CCC(NS(=O)(=O)c1cc(Cl)c(N)c(Cl)c1)C(=O)N1CCC(C(F)(F)F)CC1 10.1016/j.bmcl.2016.09.047
58508981 148787 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 472 7 2 5 3.4 CC1CCN(C(=O)C(CCn2cccc2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3940706 148787 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 472 7 2 5 3.4 CC1CCN(C(=O)C(CCn2cccc2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
134152132 153520 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 399 7 2 5 1.7 CN(C)C(=O)C(CCn1cccc1C#N)NS(=O)(=O)c1cccc2[nH]ccc12 10.1016/j.bmcl.2016.09.047
CHEMBL3979899 153520 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 399 7 2 5 1.7 CN(C)C(=O)C(CCn1cccc1C#N)NS(=O)(=O)c1cccc2[nH]ccc12 10.1016/j.bmcl.2016.09.047
145953024 162590 None 0 Human Functional pIC50 = 6.4 6.4 4 5
Antagonist activity at human CCR10 expressed in human U2OS cells assessed as inhibition of CCL27-induced beta-arrestin recruitment pre-incubated for 30 mins before CCL27 stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human CCR10 expressed in human U2OS cells assessed as inhibition of CCL27-induced beta-arrestin recruitment pre-incubated for 30 mins before CCL27 stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C/c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL4168948 162590 None 0 Human Functional pIC50 = 6.4 6.4 4 5
Antagonist activity at human CCR10 expressed in human U2OS cells assessed as inhibition of CCL27-induced beta-arrestin recruitment pre-incubated for 30 mins before CCL27 stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human CCR10 expressed in human U2OS cells assessed as inhibition of CCL27-induced beta-arrestin recruitment pre-incubated for 30 mins before CCL27 stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C/c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
58509360 152960 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 464 7 1 5 3.5 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3ccccc23)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3975141 152960 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 464 7 1 5 3.5 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3ccccc23)CC1 10.1016/j.bmcl.2016.09.047
134132126 144750 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)[C@@H](CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3908983 144750 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)[C@@H](CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509026 150164 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 498 7 2 7 2.6 CC1CCN(C(=O)C(CCn2ccnc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3951650 150164 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 498 7 2 7 2.6 CC1CCN(C(=O)C(CCn2ccnc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509147 151733 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 507 7 2 6 3.4 CC1CCN(C(=O)C(CCn2ccnc2Cl)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3964547 151733 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 507 7 2 6 3.4 CC1CCN(C(=O)C(CCn2ccnc2Cl)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509216 142509 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)C1 10.1016/j.bmcl.2016.09.047
CHEMBL3890608 142509 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)C1 10.1016/j.bmcl.2016.09.047
58509038 146101 None 0 Human Functional pIC50 = 7.2 7.2 50 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 498 7 2 7 2.6 CC1CCN(C(=O)C(CCn2nccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3919363 146101 None 0 Human Functional pIC50 = 7.2 7.2 50 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 498 7 2 7 2.6 CC1CCN(C(=O)C(CCn2nccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509138 151309 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)cc2Cl)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3960764 151309 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)cc2Cl)CC1 10.1016/j.bmcl.2016.09.047
44252324 142388 None 1 Mouse Functional pIC50 = 7.2 7.2 -42 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3889627 142388 None 1 Mouse Functional pIC50 = 7.2 7.2 -42 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
58509350 144658 None 2 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3908230 144658 None 2 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58504873 146960 None 0 Human Functional pIC50 = 6.2 6.2 17 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 483 7 2 4 4.1 CC1CCN(C(=O)[C@@H](CCc2ccccc2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3926111 146960 None 0 Human Functional pIC50 = 6.2 6.2 17 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 483 7 2 4 4.1 CC1CCN(C(=O)[C@@H](CCc2ccccc2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509063 150644 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)C1 10.1016/j.bmcl.2016.09.047
CHEMBL3955499 150644 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)C1 10.1016/j.bmcl.2016.09.047
58508974 149416 None 0 Mouse Functional pIC50 = 5.2 5.2 -50 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 467 7 1 6 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3c2ccn3C)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3945769 149416 None 0 Mouse Functional pIC50 = 5.2 5.2 -50 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 467 7 1 6 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3c2ccn3C)CC1 10.1016/j.bmcl.2016.09.047
58509350 144658 None 2 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3908230 144658 None 2 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
134135125 144182 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)[C@@H](CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3904154 144182 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)[C@@H](CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
44252464 146667 None 0 Human Functional pIC50 = 8.1 8.1 89 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3923733 146667 None 0 Human Functional pIC50 = 8.1 8.1 89 2
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1016/j.bmcl.2016.09.047
58509246 147170 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.4 CC1CCCCN1C(=O)C(CCn1cccc1C#N)NS(=O)(=O)c1cc(Cl)c(N)c(Cl)c1 10.1016/j.bmcl.2016.09.047
CHEMBL3927890 147170 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 497 7 2 6 3.4 CC1CCCCN1C(=O)C(CCn1cccc1C#N)NS(=O)(=O)c1cc(Cl)c(N)c(Cl)c1 10.1016/j.bmcl.2016.09.047
58509350 144658 None 2 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assay
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3908230 144658 None 2 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assay
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509350 144658 None 2 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assay
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3908230 144658 None 2 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assayAntagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assay
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
66883409 148989 None 0 Mouse Functional pIC50 = 5.1 5.1 -31 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3cc[nH]c23)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3942284 148989 None 0 Mouse Functional pIC50 = 5.1 5.1 -31 2
Antagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assayAntagonist activity at mouse CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3cc[nH]c23)CC1 10.1016/j.bmcl.2016.09.047
131801164 629 None 0 Mouse Functional pIC50 = 7.6 7.6 -25 2
UnclassifiedUnclassified
Guide to Pharmacology 453 7 2 5 2.8 N#Cc1cccn1CC[C@H](C(=O)N1CCC(CC1)C)NS(=O)(=O)c1cccc2c1cc[nH]2 27692854
9714 629 None 0 Mouse Functional pIC50 = 7.6 7.6 -25 2
UnclassifiedUnclassified
Guide to Pharmacology 453 7 2 5 2.8 N#Cc1cccn1CC[C@H](C(=O)N1CCC(CC1)C)NS(=O)(=O)c1cccc2c1cc[nH]2 27692854
131801164 629 None 0 Human Functional pIC50 = 9 9.0 25 2
UnclassifiedUnclassified
Guide to Pharmacology 453 7 2 5 2.8 N#Cc1cccn1CC[C@H](C(=O)N1CCC(CC1)C)NS(=O)(=O)c1cccc2c1cc[nH]2 27692854
9714 629 None 0 Human Functional pIC50 = 9 9.0 25 2
UnclassifiedUnclassified
Guide to Pharmacology 453 7 2 5 2.8 N#Cc1cccn1CC[C@H](C(=O)N1CCC(CC1)C)NS(=O)(=O)c1cccc2c1cc[nH]2 27692854


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
44252324 142388 None 1 Human Binding pIC50 = 9 9.0 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3889627 142388 None 1 Human Binding pIC50 = 9 9.0 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
44252324 142388 None 1 Human Binding pIC50 = 8 8.0 - 0
Antagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP bindingAntagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP binding
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3889627 142388 None 1 Human Binding pIC50 = 8 8.0 - 0
Antagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP bindingAntagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP binding
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1 10.1016/j.bmcl.2016.09.047
44252468 152589 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3[nH]ccc3c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3971886 152589 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3[nH]ccc3c2)CC1 10.1016/j.bmcl.2016.09.047
58509125 149205 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 474 7 2 7 2.2 CC1CCN(C(=O)C(CCn2nccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3943972 149205 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 474 7 2 7 2.2 CC1CCN(C(=O)C(CCn2nccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509238 149829 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 473 7 2 6 2.8 CC1CCN(C(=O)C(CCn2cccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3948828 149829 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 473 7 2 6 2.8 CC1CCN(C(=O)C(CCn2cccn2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
44252464 146667 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3923733 146667 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 453 7 2 5 2.8 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2ccc3cc[nH]c3c2)CC1 10.1016/j.bmcl.2016.09.047
58509213 150104 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3951018 150104 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509213 150104 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Antagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP bindingAntagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP binding
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3951018 150104 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Antagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP bindingAntagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP binding
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509147 151733 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 507 7 2 6 3.4 CC1CCN(C(=O)C(CCn2ccnc2Cl)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3964547 151733 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 507 7 2 6 3.4 CC1CCN(C(=O)C(CCn2ccnc2Cl)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509213 150104 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysisDisplacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysis
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3951018 150104 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysisDisplacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysis
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509213 150104 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysisDisplacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysis
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3951018 150104 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysisDisplacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysis
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509213 150104 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Reversible inhibition of human CCL27-Fc binding to CCR10 expressed in HEK cell membranes by immunochemical binding assayReversible inhibition of human CCL27-Fc binding to CCR10 expressed in HEK cell membranes by immunochemical binding assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3951018 150104 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Reversible inhibition of human CCL27-Fc binding to CCR10 expressed in HEK cell membranes by immunochemical binding assayReversible inhibition of human CCL27-Fc binding to CCR10 expressed in HEK cell membranes by immunochemical binding assay
ChEMBL 497 7 2 6 3.2 CC1CCN(C(=O)C(CCn2cccc2C#N)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509350 144658 None 2 Human Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3908230 144658 None 2 Human Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58504873 146960 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 483 7 2 4 4.1 CC1CCN(C(=O)[C@@H](CCc2ccccc2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3926111 146960 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 483 7 2 4 4.1 CC1CCN(C(=O)[C@@H](CCc2ccccc2)NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509350 144658 None 2 Human Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
CHEMBL3908230 144658 None 2 Human Binding pIC50 = 7.3 7.3 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 518 8 2 8 2.7 CC1CCN(C(=O)C(CCn2ccnc2[N+](=O)[O-])NS(=O)(=O)c2cc(Cl)c(N)c(Cl)c2)CC1 10.1016/j.bmcl.2016.09.047
58509165 147875 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 457 7 2 6 2.6 Cc1ccc(S(=O)(=O)NC(CCn2cccc2C#N)C(=O)N2CCC(C)CC2)c(C)c1N 10.1016/j.bmcl.2016.09.047
CHEMBL3933303 147875 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisAntagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis
ChEMBL 457 7 2 6 2.6 Cc1ccc(S(=O)(=O)NC(CCn2cccc2C#N)C(=O)N2CCC(C)CC2)c(C)c1N 10.1016/j.bmcl.2016.09.047