GPCRdb

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Ligand source activities (1 row/activity)

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Potency

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

adomeglivant	287	None	32	Human	Binding	pKi	=	-	8.18	-	1	Unclassified	Guide to Pharmacology	555.3	10	2	3	7.93	Cc1cc(O[C@@H](CCC(F)(F)F)c2ccc(C(=O)NCCC(=O)O)cc2)cc(C)c1-c1ccc(C(C)(C)C)cc1	https://pubmed.ncbi.nlm.nih.gov/26681715
adomeglivant	287	None	32	Human	Binding	pKi	=	-	8.18	-	1	Unclassified	Guide to Pharmacology	555.3	10	2	3	7.93	Cc1cc(O[C@@H](CCC(F)(F)F)c2ccc(C(=O)NCCC(=O)O)cc2)cc(C)c1-c1ccc(C(C)(C)C)cc1	https://pubmed.ncbi.nlm.nih.gov/25656305
adomeglivant	287	None	32	Human	Binding	Ki	=	6.60	8.18	-	1	Inhibition of human GCGR receptor	ChEMBL	555.3	10	2	3	7.93	Cc1cc(O[C@@H](CCC(F)(F)F)c2ccc(C(=O)NCCC(=O)O)cc2)cc(C)c1-c1ccc(C(C)(C)C)cc1	https://dx.doi.org/10.1016/j.ejmech.2018.04.061
BAY27-9955	580	None	14	Human	Binding	Ki	=	356.00	6.45	-	1	Displacement of [125I]Glucagon-Cex from human GCGR	ChEMBL	342.2	6	1	1	6.75	CCCc1c(C(C)C)cc(C(C)C)c(C(C)O)c1-c1ccc(F)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.10.113
CHEMBL104137	4806	None	0	Human	Binding	IC50	=	10000.00	5.00	-	1	Binding affinity for human Glucagon Receptor	ChEMBL	321.1	4	2	5	2.71	COc1cc(C(=O)N/N=C/c2ccnc3ccccc23)ccc1O	https://dx.doi.org/10.1021/jm000547o
CHEMBL104338	4864	None	0	Human	Binding	IC50	=	2900.00	5.54	-	1	Binding affinity for human Glucagon Receptor	ChEMBL	350.1	5	2	5	3.33	COc1cc(C(=O)N/N=C/c2ccc(OC)c3ccccc23)ccc1O	https://dx.doi.org/10.1021/jm000547o
CHEMBL104735	4945	None	0	Human	Binding	IC50	=	720.00	6.14	-	1	Binding affinity for human Glucagon Receptor	ChEMBL	336.1	4	3	5	3.02	COc1cc(C(=O)N/N=C/c2ccc(O)c3ccccc23)ccc1O	https://dx.doi.org/10.1021/jm000547o
CHEMBL104761	4951	None	0	Human	Binding	IC50	=	4800.00	5.32	-	1	Binding affinity for human Glucagon Receptor	ChEMBL	320.1	4	2	4	3.32	COc1cc(C(=O)N/N=C/c2cccc3ccccc23)ccc1O	https://dx.doi.org/10.1021/jm000547o
CHEMBL105565	5098	None	0	Human	Binding	IC50	=	12000.00	4.92	-	1	Binding affinity for human Glucagon Receptor	ChEMBL	384.1	5	2	5	4.39	COc1cc(C(=O)N/N=C/c2ccc(-c3ccc(C)c(Cl)c3)o2)ccc1O	https://dx.doi.org/10.1021/jm000547o
CHEMBL106058	5191	None	0	Human	Binding	IC50	=	60000.00	4.22	-	1	Binding affinity for human Glucagon Receptor	ChEMBL	370.1	4	3	5	3.68	COc1cc(C(=O)N/N=C/c2ccc(O)c3ccccc23)cc(Cl)c1O	https://dx.doi.org/10.1021/jm000547o
CHEMBL106134	5209	None	7	Human	Binding	IC50	=	4900.00	5.31	-	1	Binding affinity for human Glucagon Receptor	ChEMBL	320.1	4	2	4	3.32	COc1ccc(/C=N/NC(=O)c2ccc(O)cc2)c2ccccc12	https://dx.doi.org/10.1021/jm000547o
CHEMBL106294	5239	None	0	Human	Binding	IC50	=	8100.00	5.09	-	1	Binding affinity for human Glucagon Receptor	ChEMBL	363.2	5	2	5	3.38	COc1cc(C(=O)N/N=C/c2ccc(N(C)C)c3ccccc23)ccc1O	https://dx.doi.org/10.1021/jm000547o
CHEMBL106320	5243	None	0	Human	Binding	IC50	=	43000.00	4.37	-	1	Binding affinity for human Glucagon Receptor	ChEMBL	312.1	5	2	4	3.29	COc1cc(C(=O)N/N=C/c2ccc(C(C)C)cc2)ccc1O	https://dx.doi.org/10.1021/jm000547o
CHEMBL106577	5294	None	0	Human	Binding	IC50	=	6300.00	5.20	-	1	Binding affinity for human Glucagon Receptor	ChEMBL	387.2	5	2	5	4.29	CCn1c2ccccc2c2cc(/C=N/NC(=O)c3ccc(O)c(OC)c3)ccc21	https://dx.doi.org/10.1021/jm000547o
CHEMBL106795	5330	None	0	Human	Binding	IC50	=	43000.00	4.37	-	1	Binding affinity for human Glucagon Receptor	ChEMBL	354.1	5	2	5	3.06	COc1cc(C(=O)N/N=C/c2ccc(OC(F)(F)F)cc2)ccc1O	https://dx.doi.org/10.1021/jm000547o
CHEMBL107069	5386	None	0	Human	Binding	IC50	=	390.00	6.41	-	1	Binding affinity for human Glucagon Receptor	ChEMBL	324.1	3	3	4	3.15	O=C(N/N=C/c1ccc(O)c2ccccc12)c1ccc(O)c(F)c1	https://dx.doi.org/10.1021/jm000547o
CHEMBL107070	5387	None	0	Human	Binding	IC50	=	200.00	6.70	-	1	Binding affinity towards human Glucagon Receptor by the displacement of [125I]-glucagon	ChEMBL	340.1	3	3	4	3.67	O=C(N/N=C/c1ccc(O)c2ccccc12)c1ccc(O)c(Cl)c1	https://dx.doi.org/10.1021/jm000547o
CHEMBL107070	5387	None	0	Human	Binding	IC50	=	203.00	6.69	-	1	In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells	ChEMBL	340.1	3	3	4	3.67	O=C(N/N=C/c1ccc(O)c2ccccc12)c1ccc(O)c(Cl)c1	https://dx.doi.org/10.1021/jm0208572
CHEMBL107070	5387	None	0	Human	Binding	IC50	=	200.00	6.70	-	1	In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon	ChEMBL	340.1	3	3	4	3.67	O=C(N/N=C/c1ccc(O)c2ccccc12)c1ccc(O)c(Cl)c1	https://dx.doi.org/10.1016/s0960-894x(01)00819-8
CHEMBL107258	5422	None	2	Human	Binding	IC50	=	23000.00	4.64	-	1	Binding affinity for human Glucagon Receptor	ChEMBL	309.1	4	3	4	2.65	COc1cc(C(=O)N/N=C/c2c[nH]c3ccccc23)ccc1O	https://dx.doi.org/10.1021/jm000547o

Showing 1 to 20 of 1,251 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)